Aims. Complex joint fractures of the lower extremity are often accompanied by soft-tissue swelling and are associated with prolonged hospitalization and soft-tissue complications. The aim of the study was to evaluate the effect of vascular impulse technology (VIT) on soft-tissue conditioning in comparison with conventional elevation. Methods. A total of 100 patients were included in this prospective, randomized, controlled monocentre study allocated to the three subgroups of dislocated ankle fracture (n = 40), pilon fracture (n = 20), and intra-articular calcaneal fracture (n = 40). Patients were randomized to the two study groups in a 1:1 ratio. The effectiveness of VIT (intervention) compared with elevation (control) was analyzed separately for the whole study population and for the three subgroups. The primary endpoint was the time from admission until operability (in days). Results. The mean length of time until operability was 8.2 days (SD 3.0) in the intervention group and 10.2 days (SD 3.7) in the control group across all three fractures groups combined (p = 0.004). An analysis of the subgroups revealed that a significant reduction in the time to operability was achieved in two of the three: with 8.6 days (SD 2.2) versus 10.6 days (SD 3.6) in ankle fractures (p = 0.043), 9.8 days (SD 4.1) versus 12.5 days (SD 5.1) in pilon fractures (p = 0.205), and 7.0 days (SD 2.6) versus 8.4 days (SD 1.5) in calcaneal fractures (p = 0.043). A lower length of stay (p = 0.007), a reduction in pain (p. preop. = 0.05; p. discharge. < 0.001) and need for narcotics (p. preop. = 0.064; p. postop. = 0.072), an increased reduction in swelling (p < 0.001), and a lower revision rate (p = 0.044) could also be seen, and a trend towards fewer complications (p = 0.216) became apparent. Conclusion. Compared with elevation, VIT results in a significant reduction in the time to achieve operability in complex joint fractures of the lower limb. Cite this article: Bone Joint J 2021;103-B(4):746–754

Aims. Both anatomical and reverse total shoulder arthroplasty (aTSA and rTSA) provide functional improvements. A reported benefit of aTSA is better range of motion (ROM). However, it is not clear which procedure provides better outcomes in patients with limited foward elevation (FE). The aim of this study was to compare the outcome of aTSA and rTSA in patients with glenohumeral osteoarthritis (OA), an intact rotator cuff, and limited FE. Methods. This was a retrospective review of a single institution’s prospectively collected shoulder arthroplasty database for TSAs undertaken between 2007 and 2020. A total of 344 aTSAs and 163 rTSAs, which were performed in patients with OA and an intact rotator cuff with a minimum follow-up of two years, were included. Using the definition of preoperative stiffness as passive FE ≤ 105°, three cohorts were matched 1:1 by age, sex, and follow-up: stiff aTSAs (85) to non-stiff aTSAs (85); stiff rTSAs (74) to non-stiff rTSAs (74); and stiff rTSAs (64) to stiff aTSAs (64). We the compared ROMs, outcome scores, and complication and revision rates. Results. Compared with non-stiff aTSAs, stiff aTSAs had poorer passive FE and active external rotation (ER), whereas there were no significant postoperative differences between stiff rTSAs and non-stiff rTSAs. There were no significant differences in preoperative function when comparing stiff aTSAs with stiff rTSAs. However, stiff rTSAs had significantly greater postoperative active and passive FE (p = 0.001 and 0.004, respectively), and active abduction (p = 0.001) compared with stiff aTSAs. The outcome scores were significantly more favourable in stiff rTSAs for the Shoulder Pain and Disability Index, Simple Shoulder Test, American Shoulder and Elbow Surgeons score, University of California, Los Angeles score, and the Constant score, compared with stiff aTSAs. When comparing the proportion of stiff aTSAs versus stiff rTSAs that exceeded the minimal clinically important difference and substantial clinical benefit, stiff rTSAs achieved both at greater rates for all measurements except active ER. The complication rate did not significantly differ between stiff aTSAs and stiff rTSAs, but there was a significantly higher rate of revision surgery in stiff aTSAs (p = 0.007). Conclusion. Postoperative overhead ROM, outcome scores, and rates of revision surgery favour the use of a rTSA rather than aTSA in patients with glenohumeral OA, an intact rotator cuff and limited FE, with similar rotational ROM in these two groups. Cite this article: Bone Joint J 2023;105-B(12):1303–1313

We studied the position and rotational changes associated with elevation of the glenohumeral joint, using a three-dimensional magnetic-field tracking system on nine fresh cadaveric shoulders. The plane of maximal arm elevation was shown to occur 23 degrees anterior to the plane of the scapula. Elevation in any plane anterior to the scapula required external humeral rotation, and maximal elevation was associated with approximately 35 degrees of external humeral rotation. Conversely, internal rotation was necessary for increased elevation posterior to the plane of the scapula. The observed effects of this rotation were to clear the humeral tuberosity from abutting beneath the acromion and to relax the inferior capsular ligamentous constraints. Measurement of the obligatory humeral rotation required for maximal elevation helps to explain the relationship of the limited elevation seen in adhesive capsulitis and after operations which limit external rotation

Aims. The aim of this study was to compare the pain caused by the application of a tourniquet after exsanguination of the upper limb with that occurring after simple elevation. . Patients and Methods. We used 26 healthy volunteers (52 arms), each of whom acted as their own matched control. The primary outcome measure was the total pain experienced by each volunteer while the tourniquet was inflated for 20 minutes. This was calculated as the area under the pain curve for each individual subject. Secondary outcomes were pain at each time point; the total pain experienced during the recovery phase; the ability to tolerate the tourniquet and the time for full recovery after deflation of the tourniquet. . Results. There was a significant difference in the area under the pain curves in favour of exsanguination (mean difference 8.4; 95% confidence interval (CI) 3.0 to 13.7, p = 0.004). There was no difference between the dominant and non-dominant arms (mean difference -0.2; 95% CI -23.2 to 22.8, p = 0.99). The area under both recovery curves were similar (mean difference 0.7; 95% CI -6.0 to 4.6, p = 0.78). There was no statistical difference in recovery time, the actual mean difference being 30 seconds longer in the elevation group (p = 0.06). Conclusion. Many orthopaedic and plastic surgery procedures are done under local anaesthetic or regional block where a bloodless field and a motionless patient are essential. Optimising patient comfort during surgery with the tourniquet inflated is thus a priority. This study is useful in that it compares two common methods of preparation of the upper limb prior to tourniquet inflation and which have not previously been compared in this context. Following on the results of this study, we can confidently conclude that exsanguinating the upper limb before inflating a tourniquet is more comfortable than simply elevating the arm for patients undergoing a procedure under local or regional block, both during the procedure and in the recovery phase. . Take home message: Exsanguination rather than elevation is recommended in order to minimise patient discomfort and optimise the surgical field. Cite this article: Bone Joint J 2016;98-B:519–25

The elevation of the joint line is considered a possible cause of mid-flexion instability in total knee arthroplasty (TKA). The authors evaluated the effects of joint line change on mid-flexion stability in cruciate retaining TKA. Seventy-nine knees treated by cruciate retaining TKA using a modified balanced gap technique were included in this prospective study. After prosthesis insertion, valgus and varus stabilities were measured under valgus and varus stress using a navigation system at 0, 30, 60 and 90° of knee flexion. Changes of joint lines were measured preoperatively and postoperatively and compared. The knees were allocated to a “No change group (≤4mm, 62 patients)” or to an “Elevation group (>4mm, 17 patients)”. Medio-lateral stabilities (defined as the sums of valgus and varus stabilities measured intra-operatively) were compared in the two groups. The mean joint line elevation was 4.6mm in the no change group and 1.7mm in the elevation group. Mean medio-lateral stability at 30° of knee flexion was 4.8±2.3 mm in the no change group and 6.3±2.7 mm in the elevation group, and these values were significantly different (p = 0.02). However, no significant differences in medio-lateral stability were observed at other flexion angles (p>0.05). Knees with a < 5mm joint line elevation provide better mid-flexion stability after TKA. The results of this study suggest that a < 5mm elevation in joint line laxity is acceptable for cruciate retaining TKA

Introduction: Most hospitals that treat patients with Pectus Excavatum use the pectus bar designed by D. Nuss. In essence, chest elevation is achieved by using a previously moulded steel bar. It is relatively safe since the introduction of thoracoscopy, although there is a risk of injury to the heart. Our group has attempted to diminish this risk by means of sternal traction using a clamp specially designed for use with a thorascope anchored in the cancellous tissue of the sternum. Materials and methods: We used a tailored clamp in three consecutive patients aged 8, 12 and 15 with Pectus Excavatum Haller index > 7. Procedure: Thorascopy was performed for a good assessment of the rib cage. Under direct vision, we inserted one arm of the clamp underneath the sternum at the deepest point of the defect about 5 cm to the right of the midline. With the other arm of the clamp we grasped the anterior side of the sternum percutaneously. When the clamp was closed, we could raise the sternum to increase the mediastinal space. Results: The sternal elevation was satisfactory. Using thorascopy during the procedure enhanced safety and the additional time was a few minutes. Conclusions: Correction of pectus excavatum is indicated for aesthetic purposes in many patients and the absence of severe complications is a goal. The sternal elevation described here (although it is only a preliminary study) is fast, economical and appears to make the Nuss procedure safer

Introduction. Wear debris from polyethylene tibial inserts has been associated with limited longevity of total knee replacements (TKRs). While material factors were studied extensively and considerable progress has been made, there is little knowledge about surgical factors, particularly on how the wear rate is related to implant positioning. It was the purpose of this study to determine the combined effect of patient and implant positioning factors on the volumetric wear rate of TKRs. Our hypothesis was that implant alignment has a significant impact on the wear rate when controlled for other patient factors. Methods. This study included 59 tibial inserts of a cruciate retaining TKR design (Nexgen, Zimmer Inc.). The patients' age, sex, weight, height, and implant size were obtained. All implants were scanned with a coordinate measuring machine. Volumetric wear was determined using an autonomous mathematical reconstruction method (Figure 1). Radiographs were used to determine the anatomic lateral distal femoral angle (aLDFA), anatomic medial proximal tibial angle (aMPTA), femoral tilt angle (FTA) and posterior tibial slope (PTS). Also, the patella position was assessed using the Blackburne-Peel Index (BPI) and the Insall-Salvati Ratio (Figure 2). General linear modeling (SPSS) was conducted in order to determine the most significant patient and implant positioning factors on wear rate. Results. After adjustment for creep, the mean volumetric wear rate was 11.6 mm. 3. /yr (Figure 2). According to the linear regression model wear increased with younger age (p=0.0014) and male sex (p<0.001). The wear rate was independent of patient weight (p=0.17). From the multiple positioning factors only BPI and tibial slope were significant and inversely correlated with wear (p=0.009 and 0.026, respectively). The average ISR was normal before and after surgery, whereas the BPI was only in the normal range prior to surgery, and dropped postop into pseudo-baja (p<0.001, Figure 3). Discussion. The effect of male sex on wear volume can partially be explained by a larger average implant size; however, other unknown confounding factors may play a role too. The effect of younger age is likely related to higher patient activity. Based on previous gait analysis, we speculate that increasing tibial slope results in larger AP translations of the knee joint and thus more wear. Interestingly, BPI remained a highly significant factor when controlled for all other factors. The average BPI clearly dropped post-operatively, whereas the average ISR did not, indicating that not true patella baja, but a joint line elevation occurred due to the reconstruction. Joint line elevation may affect the quadriceps mechanism leading to higher contact forces and subsequent higher wear. Post-operative joint line elevation can be explained by the intention to keep bone loss at a minimum, while using thick polyethylene inserts. Further studies are needed to determine the trade-offs between bone conservation and reduction of wear rate. However, this study has revealed the importance of surgical factors regarding polyethylene wear reduction in TKR. Acknowledgements. This study was funded by NIH grant R01AR059843. For figures/tables, please contact authors directly.

The aim of this study was to establish the ability of an invasive fibre-optic probe to measure intra-muscular pH, pCO. 2. , pO. 2. , HCO. 3. -. −. , ambient temperature, base excess and O. 2. saturation. The secondary aim was to determine the effect of elevation of the limb on these parameters. Fibre-optic probes were introduced into the anterior compartment muscle of the leg in five volunteers via 16G cannulae. After equilibration the limb was monitored for 11min with the volunteer supine on an examination couch. The limb was elevated to 22cm (Braun frame) and then 44cm for the same time. Subsequently the leg was returned to 22cm and supine. All volunteers followed this set protocol. Continuous recording of all indices was made throughout. Data was stored to a personal computer for analysis. Similar trends were observed across all subjects for all parameters. The mean pO. 2. when lying flat was 27mmHg (S.D.7.4). Elevation to 22cm increased muscle pO. 2. to 33 mmHg (S.D. 5.8). Further elevation to 44 cm resulted in a reduction in muscle pO. 2. to a level below that measured when supine. When the limb was returned to 22cm the pO2 trend reversed, the level improving. Returning to the supine position the pO. 2. returned to the level seen at the start of monitoring. This novel probe gives reproducible measures of pH, pCO. 2. , pO. 2. , HCO. 3. −. , ambient temperature, base excess and O. 2. saturation. Results indicate that elevation to 22cm improves muscle oxygenation; a height of 44cm seems detrimental. This technique may be applicable in surveillance for compartment syndromes and muscle ischaemia

Introduction:. Acetabular revision Jumbo cups are used in revision hip surgeries to allow for large bone to implant contact and stability. However, jumbo cups may also result in hip center elevation and instability. They may also protrude through anterior wall leading to ilopsoas tendinitis. Methods:. The study was conducted using two methods:. Computer simulation study. 265 pelvic CT scans consisting of 158 males and 107 females were converted to virtual 3-dimensional bones. The average native acetabular diameter was 52.0 mm, SD = 4.0 mm (males in 52.4 mm, SD = 2.8 mm and 46.4 mm, SD = 2.6 mm in females). Images were analyzed by custom CT analytical software (SOMA™ V.3.2). 1. and over-sized reaming was simulated. Four distinct points, located in and around the acetabular margins, were used to determine the reamer sphere. Points 1, 2, 3 were located at the inferior and inferior-medial acetabular margins, and Point 4 was located superiorly and posteriorly in the acetabulum to simulate a bony defect in this location, Point 4 was placed at 10%, 20%, 30%, 40%, 50% and 60% of the distance from the superior – posterior margin of the acetabular rim to the sciatic notch to simulate bony defects of increasing size. (Figure 1). Radiographical study. Retrospective chart review of patient records for all cementless acetabular revisions utilizing jumbo cups between January 1, 1998 and March 30, 2012 at UCFS (98 patients with 57 men, 41 women). Jumbo cups: ≥66 mm in males; <62 mm in females. Reaming was directed inferiorly to the level of the obturator foramen to place the inferior edge of the jumbo cup at the inferior acetabulum. To determine the vertical position of the hip center, a circle was first made around both the jumbo and the contralateral acetabular surfaces using Phillips iSite PACS software. The center of this circle was assumed to correspond to the “hip center”. The height of the hip center was estimated by measuring the height of a perpendicular line arising from the interteardrop line (TL) and ending at the hip center. Results:. The computer simulation and radiographic analysis deomonstrated similar results. The computer simulation predicted that the hip center shifted superiorly and anteriorly as the reamer size increased. The hip center shifted 0.27 mm superiorly and 0.02 mm anteriorly for every millimeter in diameter increased for the reaming. (Figure 2) Anterior column bone removal was increased 0.86 mm for every 1 mm of reamer size increase. (Figure 3). Results of radiographical study is shown in Table bellow:. Discussion:. Use of a jumbo cup in revision THA results in elevation of the hip center. Therefore a longer femoral head may be needed to compensate for hip center elevation when a jumbo cup is used. Reaming for a jumbo cup can also result in loss of anterior bone stock and protrusion of the cup anteriorly which may cause iliopsoas tendonitis

Background. Severe infantile Blount's disease can result in a multiplanar deformity of the proximal tibia with both intra-articular and metaphyseal components. Correction can represent a significant surgical challenge. We describe our results using the Taylor spatial frame for acute tibial hemiplateau elevation combined with gradual metaphyseal correction in patients with severe infantile blounts with an associated physeal bony bar. Methods. Eight patients (10 knees) underwent tibial hemiplateau elevation and metaphyseal correction with use of the Taylor Spatial Frame between 2012–2016. We undertook a retrospective case note and radiographic review of all patients to assess clinical and radiographic outcomes. Mean age at the time of surgery of was 11.7 years and mean length of follow up was 16.8 months. Results. At time of latest follow up all patients reported no hip, knee or ankle pain. All knees were clinically stable without lateral thrust during gait. Improvement in radiographic parameters was seen in all patients. The mean tibiofemoral angle improved from −28.3 to 5.9 degrees post operatively. The angle between femoral condyles and the tibial shaft improved from a mean of 56.3 degrees to 90.3 degrees. The joint depression angle was also seen to improve from mean 47.4 degrees to 9.8 degrees. No significant complications were seen. Conclusion. This technique has been shown to be an effective method of correction of the complex deformity encountered in severe infantile Blount's disease. Use of the Taylor spatial frame may provide certain advantages in comparison to previously described approaches. Level of Evidence: Level IV (Case Series)

Introduction. Optimal knee joint function obviously requires a delicate balance between the osseous anatomy and the surrounding soft tissues, which is distorted in the case of joint line elevation (JLE). Although several studies have found no correlation between JLE and outcome, others have linked JLE to inferior results. The purpose of this in vitro investigation was to evaluate the effect of JLE on tibiofemoral kinematics and collateral ligament strains. Materials and Methods. Six cadaver knees were equipped with reflective markers on femur and tibia and CT scans were made. A total knee arthroplasty (TKA) was performed preserving the native joint level. The knees were then tested in passive flexion-extension and squatting in a knee kinematics simulator while marker positions were recorded with an optical system. During squatting quadriceps forces were measured as well as tibio-femoral contact pressures. Finally, a revision TKA was performed with JLE by 4 mm. The femoral component was downsized and a thicker insert was used. The knees were again tested as before. Based on the bony landmarks identified in the CT scans and the measured trajectories of the markers, relative tibiofemoral kinematics could be calculated as well as distance changes between insertions of the collateral ligaments. Statistical tests were carried out to detect significant differences in kinematic patterns, ligaments elongation, tibiofemoral contact pressures and quadriceps forces between the primary TKA and after JLE. Results. Tibiofemoral kinematics are shown in Figure 1. For both passive flexion and squatting, tibial external rotation and adduction were similar before and after JLE. In passive flexion, JLE decreased the posterior translation of the femoral medial and lateral condyle centres, especially beyond 40 degrees of flexion. A slight 5% anterior shift of both centres was noted after JLE during squatting, but this was not significant. Strains in the collateral ligaments are shown in Figure 2. The collateral ligament lengths remained constant during passive flexion and were unaffected by elevation of the joint line. During squatting, the sMCL stretched with flexion after primary TKA and this behaviour stayed constant when the joint line was elevated. The LCL showed a similar loosening trend in both TKA configurations. Also tibiofemoral joint kinetics were not affected by JLE: quadriceps force and contact pressures all remained essentially unchanged during squatting before and after JLE. Discussion and conclusion. Although clinical observations have indicated that JLE is associated with inferior clinical results, the effects of JLE on knee biomechanics which might explain these outcomes remain relatively unknown. In this study, we specifically evaluated those effects on tibiofemoral kinematics and kinetics, as well as elongation of the collateral ligaments. As our current study did not detect any effect of JLE in tibiofemoral kinematics, kinetics, and strains of collateral ligaments in revision TKA, it is possible that these effects may be limited to or triggered at the patello-femoral joint, and more significant with higher joint line elevations than the 4-mm level tested in the current study. This hypothesis needs to be further investigated in future in-vitro and in-vivo studies

1. One hundred cases of congenital elevation of the scapula are reviewed; thirty-four were treated by operation. 2. A method of grading of appearance is suggested to assist in selecting cases for operation. 3. In very mild cases operation does not confer worthwhile benefit. 4. Very severely affected patients cannot be made to look normal. 5. The appearance often deteriorates during a period of rapid growth of the neck, making continued observation and reassessment essential. 6. The primary aim of treatment is to improve appearance; improvement in function is uncertain. 7. Excision of the supero-medial part of the scapula, and of the omo-vertebral bone when present, is recommended in most cases requiring operation. It is safe and simple, with little risk of loss of function and with simple after-treatment

Accurate and reproducible measurement of three-dimensional shoulder kinematics would contribute to better understanding shoulder mechanics, and therefore to better diagnosing and treating shoulder pathologies. Current techniques of 3D kinematics analysis use external markers (acromial cluster or scapula locator) or medical imaging (MRI or CT-Scan). However those methods present some drawbacks such as skin movements for external markers or cost and irradiation for imaging techniques. The EOS low dose biplanar X-Rays system can be used to track the scapula, humerus and thorax for different arm elevation positions. The aim of this study is to propose a novel method to study scapulo-thoracic kinematics from biplanar X-rays and to assess its reliability during abduction in the scapular plane. This study is based on the EOS™ system (EOS Imaging, Paris, France), which allows acquisition of 2 calibrated, low dose, orthogonal radiographs with the subject standing at 30 to 40° angle of coronal rotation to the plane of one of the X-ray beams, in order to limit superimposition with the ribcage and spine. Seven abduction positions in the scapular plane were maintained by the subjects for 10 seconds, during X-ray acquisition. Between two positions, the subjects returned at rest position. Arm elevations were approximately 0, 10, 20, 30, 60, 90 and 150° (position 1 to 7). Six subjects were enrolled to perform a reproducibility study based on the 3D reconstructions of 2 experienced observers three times each. For each subject, a personalised 3D reconstruction of the scapula was created. The observer digitises clearly visible anatomical landmarks on both stereoradiographs for each arm position. These landmarks are used to make a first adjustment of a parameterised 3D model of the scapula. This provides a pre-personalised model of the subject's scapula which is then rigidly registered on each pair of X-rays until its retroprojection fits best on the contours that are visible on the X-rays. The thorax coordinate system (CS) was built following the ISB (International Society of Biomechanics) recommendations. The CS associated to the scapula was a glenoid centred CS based on the ellipse which fit on the glenoid rim on the 3D model of scapula. Scapular CS orientation and translation in the thorax CS was calculated following a Y,X,Z angle sequence for each position. Each 3D reconstruction of the scapula was performed in approximately 30 minutes. The most reproducible rotation was upward/downward rotation (along X axis) with a 95% confidence interval (95% CI) from 2.71° to 3.61°. Internal/external rotation and anterior/posterior tilting were comprised respectively between 5.18° to 8.01° and 5.50° to 7.23° (CI 95%). The most reproducible translation was superior-inferior translation (along Y axis) with a 95% CI from 1.22mm to 2.46mm. Translation along X axis (antero-posterior) and Z axis (medio-lateral) were comprised respectively between 2.49mm to 4.26mm and 2.47mm to 3.30mm (CI 95%). We presented a new technique for 3D functional quantitative analysis of the scapulo-thoracic joint. This technique can be used with confidence; uncertainty of the measures seems acceptable compared to the literature. Main advantages of this technique are the very low dose irradiation compared to the CT-Scan and the possibility to study arm elevation above 120°

We present the results of treatment for relapsed infantile Blounts disease using a technique of hemiplateau elevation with the Ilizarov frame. 7 patients with a mean age of 10 years 6 months were reviewed at 30 months following hemiplateau elevation with/without ipsilateral tibial lengthening. Preoperatively clinical photographs, long leg standing radiographs and 3D computed tomography images were acquired. The patients were evaluated clinically (presence of knee pain, range of knee motion, knee stability and leg length discrepancy) and radiologically. Schoeneckers objective assessment was undertaken. The results were analysed statistically. Clinically all the patients improved significantly. No patient had knee pain and the range of knee motion was from 0° to more than 100° of knee flexion. The radiological results and Schoeneckers grading are depicted below. The improvement in radiological measurements were statistically significant. Pin site infection was present in all but settled with antibiotics. The results of hemiplateau elevation for relapsed infantile Blounts disease are encouraging

Introduction. Higher concentrations of metal ion levels after Metal-on-metal (MoM) THA are a cause for concern. Elevated cobalt (Co) and chromium (Cr) ion levels in the blood indicate metal wear, and may predict secondary soft-tissue damage (adverse reaction to metal debris; ARMD). Although, it is well known that concentrations of metal ion levels are elevated in the short term after MoM, the long-term consequences in ion concentration and risk factors for increased ion levels are not clarified. We sequentially investigated the postoperative Co and Cr ion levels after MoM THA and the relationship between the metal ion levels and several risk factors. Materials and Methods. We reviewed the data on one hundred and eighty six patients of two hundred ninety one MoM THA cases. The one hundred eighty six patients were measured at least three times after a MoM THA surgery over a five year (2005–2010) period in our institution. Serum cobalt and chromium levels were measured by inductor coupled plasma – mass spectrometry at several times in follow-up period, (measured at the preoperative period, the third month, the sixth month, the first year, the second year, and the fourth year after MoM THA). Furthermore, we investigated the correlation between the metal ion levels and various factors which might influence the release of metal ions, such as Body mass index (BMI), renal function, femoral head size, unilateral or bilateral THA, the cup position, and postoperative activity. The renal function was evaluated by measuring estimated glomerular filtration ratio (GFR) at preoperative examination. A postoperative activity was assessed with a pedometer measurement counting number of steps a day. A cup position was evaluated by lateral inclination measured by X-ray or computed tomography. Results. Average serum Co and Cr concentrations in preoperative period were 0.69 and 0.05 mg/ ml, respectively. Postoperative serum Co and Cr ion levels were significantly increased compared with preoperative value throughout the postoperative period. There was no significant correlation with regards to BMI, renal function, femoral head size tothe metal ion level measurement. In bilateral THA cases, Co and Cr ion concentrations were significantly increased compared with unilateral THA cases. In addition, in cases that its cup inclination was more than 50 degrees, Co and Cr ion concentration were significantly increased compared with cases less than 50 degrees in the first year after surgery. There was a trend for higher metal ion levels in the group of patients who walked more than 7000 steps a day, but this did not reach statistical significance. Conclusion. Metal ion concentrations of almost patients were increased after MoM THA surgery. Side effects related to elevation of serum Co or Cr concentration were currently not identified and overall clinical results were good. However, Longer follow-up would be necessary if the patients have overlapping risk factors, because those patients may experience elevation of the level in postoperative late stage

We have treated seven children with relapsed infantile Blount’s disease by elevation of the hemiplateau using the Ilizarov frame. Three boys and four girls with a mean age of 10.5 years were reviewed at a mean of 29 months after surgery. All had improved considerably and were pleased with the results. The improvements in radiological measurements were statistically significant (p < 0.001). Three-dimensional CT reconstruction was useful for planning surgery. There were no major complications. The advantages of this technique are that in addition to elevation of the hemiplateau, rotational deformities and limb-length discrepancies may be addressed

Of forty-six patients with congenital elevation of the scapula, diastematomyelia was confirmed in four and was probably present in five others. Possible reasons for the previously unsuspected association are presented

Ulnar nerve function, during and after open reduction and internal fixation of fractures of the distal humerus with subperiosteal elevation of the nerve, was assessed by intra-operative neurophysiological monitoring. Intermittent recording of the compound muscle action potentials was taken from the hypothenar muscles in 18 neurologically asymptomatic patients. The mean amplitude of the compound muscle action potential after surgery was 98.1% (. sd. 17.6; −37% to +25%). The amplitude improved in six patients following surgery. Despite unremarkable recordings one patient had progressive paresis. Motor impairment is unlikely if the compound muscle action potential is continuously preserved and not reduced by more than 40% at the end of surgery. Temporary decreases in amplitude by up to 70% were tolerated without clinical consequences. However, repeated clinical examination is obligatory to recognise and treat early post-operative palsy

Purpose. While reverse shoulder arthroplasty (RSA) corrects vertical muscle imbalance, it cannot restore the horizontal imbalance seen in cuff-deficient shoulders with combined loss of active elevation and external rotation (CLEER). We report the medium-term results of the modified latissimus dorsi/teres major tendon transfer (L'Episcopo procedure) associated with RSA, performed via a single deltopectoral approach. Method. Sixteen CLEER patients underwent the procedure and were followed up at a mean of 49 months (range, 36–70). All patients had lost spatial control of their arm, were unable to maintain neutral rotation, and had abnormal infraspinatus and teres minor muscles on imaging. Outcome measures included Constant score (CS), Subjective Shoulder Value (SSV), and ADLER score (activities of daily living requiring external rotation). Results. Fifteen patients were satisfied or very satisfied. There were significant improvements (p<0.05) in active elevation (72 degrees to 139 degrees), active external rotation (−24 degrees to 4 degrees), CS (27 to 64), ADLER score (5.0 to 23.8) and SSV (23% to 77%). Active internal rotation decreased from 6 to 3 points. Scapular notching was observed in 3 patients and spurs in 3 patients. One deep infection required two-stage revision of the prosthesis and the patient was disappointed with the result. One patient required reoperation (arthrolysis and acromioclavicular joint excision). Conclusion. Reverse shoulder arthroplasty combined with the modified L'Episcopo procedure improves shoulder function in patients with CLEER. Patients regain spatial control of their arm. The observed internal rotation loss has led us to modify the surgical technique by fixing the transferred tendons more posteriorly on the humerus

An innovative Kirschner (K-) wire point was developed and compared in fresh pig femora in terms of drilling efficiency and temperature elevation with the trochar and diamond points currently used in clinical practice. The tips of thermal couples were machined to the defined geometry and the temperature measured during drilling. Using the same drill speed (rev/min) and feed rate, the new K-wire point produced the lowest thrust force and torque as measured by a Kistler dynamometer. Drill point temperatures were highest with the trochar geometry (129 ± 6°C), followed by the diamond (98 ± 7°C). The lowest temperatures were recorded with the Medin K-wire (66 ± 2°C). On repeated drilling it could be used for up to 30 holes before reaching the less satisfactory drill performance of the diamond tip. The new K-wire provides a better alternative as it requires less effort for insertion, generates less heat and may be re-used

Does the pre-operative range of active anterior elevation alter the outcome of reverse shoulder prosthesis? A review of 96 cases. Aims: The aim of this retrospective study was to analyse the results of reverse shoulder prosthesis in massive, irreparable rotator cuff tears in terms of the preoperative active anterior elevation (AAE). Materials and Methods: This was a retrospective study of 96 reverse shoulder prostheses in patients with a mean age of 74 years, and with an average follow-up of 30 months. We divided the patients into three groups for the purposes of the study. Group 1 had an AAE less than 60° (n=51); group 2 had an AAE between 60 and 120° (n=39); group 3 had an AAE above 120° (n=6). The majority had off-centre arthritis with a Fukuda Hamada classification of IV or V (n=77); only 19 fell within classes I, II or III. We excluded patients who had previously had a failed anterior cuff repair or arthroplasty and those with a diagnosis of rheumatoid arthritis. Results: There was no significant difference in constant score between the three groups based on preoperative AAE: group 1: 63.50; group 2: 65.05; group 3: 65.16. Analysis of the 96 reverse prostheses in relation to the Fukuda Hamada classification also showed no difference: types I, II and III had a constant score of 64.37; types IV and V a score of 63.68. However, the improvement in AAE (I), rotation (RE1 and RI) and in power was significantly greater in shoulders with pseudoparalysis (p< 0.001): group 1: I = 71.43%; group 2: I = 33.48%; group 3: I = 3.03%. The degree of improvement of the pseudoparalytic shoulders (group 1) was influenced by the Fukuda Hamada classification (p< 0.01): 77.78% for stages I, II and III compared with 69% for stages IV and V. Discusssion and conclusion: This retrospective study confirms that the reverse shoulder prosthesis is a beneficial treatment for massive, irreparable cuff tears in older patients with shoulder psuedoparalysis. Its use is debatable if the preoperative AAE is over 120°, in which case hemiarthroplasty may be a better option. The benefit of the reverse prosthesis is greatest in the shoulder with pseudoparalysis, no glenohumeral arthritis (Fukuda I, II or III), and no previous surgical intervention

We report 12 consecutive cases of vertical scapular osteotomy to correct Sprengel’s deformity, performed during a 16-year period, with a mean follow-up of 10.4 years. The mean increase in abduction of the shoulder was 53°. The cosmetic appearance improved by a mean of 1.5 levels on the Cavendish scale. Neither function nor cosmesis deteriorated with time. We recommend the procedure for correction of moderate deformities with a functional deficit.

In this outcome-based study, we reviewed the results of the modified Woodward procedure performed on 10 patients over the last 15 years in our unit. The indication for surgery was a unilateral Sprengel’s deformity, Cavendish grade II or III, in children aged 3 to 6 years. Follow-up times ranged from 1 to 15 years. The patients were assessed according to patient and relatives’ satisfaction, cosmesis and functional results.

The modified Woodward procedure entailed a midline longitudinal incision over the spinous processes from C1 to T8. The origins of the trapezius and rhomboids were released from the spinous processes, the scapula lowered and derotated, the superomedial portion of the scapula resected and the trapezius and rhomboids reattached two vertebral levels lower. The clavicle was not osteotomised in any patient. A Velpeau sling was used for four weeks, after which physiotherapy was started.

There were no brachial plexus complications. There were two cases of winging of the scapulae. One patient had a cosmetically ugly scar. Our results showed a cosmetic improvement by an average of one grade and a mean functional improvement of 30° of abduction and flexion. Those patients where an omovertebral body was found and resected had the best cosmetic and functional results. All the patients were satisfied with their operations.

We feel that the pessimism regarding surgical results is unwarranted.

Introduction

Wear and corrosion of metal-on-metal (MM) bearings releases (a) soluble metal ions which collect locally and pass into the systemic circulation and (b) insoluble particles which undergo local deposition and lymphoreticular dissemination. Debris-related failures from osteolysis, metallosis and pseudotumours warrants revision of these MM bearing devices to non-MM bearing arthroplasties with the expectation that both the systemic and local effects will be reversed with time since the source of metal ion release is removed.

The purpose of the present study is to determine (a) whether metal ion levels in blood and urine decrease after revision of a MM bearing arthroplasty to a non-MM bearing device and (b) the rate at which this decrease is effected.

Aims. Surgeons commonly resect additional distal femur during primary total knee arthroplasty (TKA) to correct a flexion contracture, which leads to femoral joint line elevation. There is a paucity of data describing the effect of joint line elevation on mid-flexion stability and knee kinematics. Thus, the goal of this study was to quantify the effect of joint line elevation on mid-flexion laxity. Methods. Six computational knee models with cadaver-specific capsular and collateral ligament properties were implanted with a posterior-stabilized (PS) TKA. A 10° flexion contracture was created in each model to simulate a capsular contracture. Distal femoral resections of + 2 mm and + 4 mm were then simulated for each knee. The knee models were then extended under a standard moment. Subsequently, varus and valgus moments of 10 Nm were applied as the knee was flexed from 0° to 90° at baseline and repeated after each of the two distal resections. Coronal laxity (the sum of varus and valgus angulation with respective maximum moments) was measured throughout flexion. Results. With + 2 mm resection at 30° and 45° of flexion, mean coronal laxity increased by a mean of 3.1° (SD 0.18°) (p < 0.001) and 2.7° (SD 0.30°) (p < 0.001), respectively. With + 4 mm resection at 30° and 45° of flexion, mean coronal laxity increased by 6.5° (SD 0.56°) (p < 0.001) and 5.5° (SD 0.72°) (p < 0.001), respectively. Maximum increased coronal laxity for a + 4 mm resection occurred at a mean 15.7° (11° to 33°) of flexion with a mean increase of 7.8° (SD 0.2°) from baseline. Conclusion. With joint line elevation in primary PS TKA, coronal laxity peaks early (about 16°) with a maximum laxity of 8°. Surgeons should restore the joint line if possible; however, if joint line elevation is necessary, we recommend assessment of coronal laxity at 15° to 30° of knee flexion to assess for mid-flexion instability. Further in vivo studies are warranted to understand if this mid-flexion coronal laxity has negative clinical implications. Cite this article: Bone Joint J 2021;103-B(6 Supple A):87–93

The June 2023 Research Roundup. 360. looks at: Characterizing recurrent infections after one-stage revision for periprosthetic joint infection of the knee; Predicted waiting times for orthopaedic surgery: an urgent need to address the deficit in capacity; Vascular impulse technology versus elevation for reducing the swelling of upper and lower limb joint fractures; Desperate patients will accept higher risks; How long does it take to find a positive culture in periprosthetic joint infection?

Aims. The aim of this study was to establish consensus statements on medial patellofemoral ligament (MPFL) reconstruction, anteromedialization tibial tubercle osteotomy, trochleoplasty, and rehabilitation and return to sporting activity in patients with patellar instability, using the modified Delphi process. Methods. This was the second part of a study dealing with these aspects of management in these patients. As in part I, a total of 60 surgeons from 11 countries contributed to the development of consensus statements based on their expertise in this area. They were assigned to one of seven working groups defined by subtopics of interest. Consensus was defined as achieving between 80% and 89% agreement, strong consensus was defined as between 90% and 99% agreement, and 100% agreement was considered unanimous. Results. Of 41 questions and statements on patellar instability, none achieved unanimous consensus, 19 achieved strong consensus, 15 achieved consensus, and seven did not achieve consensus. Conclusion. Most statements reached some degree of consensus, without any achieving unanimous consensus. There was no consensus on the use of anchors in MPFL reconstruction, and the order of fixation of the graft (patella first versus femur first). There was also no consensus on the indications for trochleoplasty or its effect on the viability of the cartilage after elevation of the osteochondral flap. There was also no consensus on postoperative immobilization or weightbearing, or whether paediatric patients should avoid an early return to sport. Cite this article: Bone Joint J 2023;105-B(12):1265–1270

The February 2024 Shoulder & Elbow Roundup. 360. looks at: Does indomethacin prevent heterotopic ossification following elbow fracture fixation?; Arthroscopic capsular shift in atraumatic shoulder joint instability; Ultrasound-guided lavage with corticosteroid injection versus sham; Combined surgical and exercise-based interventions following primary traumatic anterior shoulder dislocation: a systematic review and meta-analysis; Are vascularized fibula autografts a long-lasting reconstruction after intercalary resection of the humerus for primary bone tumours?; Anatomical versus reverse total shoulder arthroplasty with limited forward elevation; Tension band or plate fixation for simple displaced olecranon fractures?; Is long-term follow-up and monitoring in shoulder and elbow arthroplasty needed?

Abstract. Introduction. Several studies have reported significant cobalt(Co) and chromium(Cr) elevations in the blood of patients with total-knee-replacements (TKRs), and histological signs of metal sensitivity have been reported in up to 44% of patients undergoing revision of their TKRs. We carried out this investigation to determine the source and quantity of metal release in TKRs. Methodology. We identified all TKRs with polished CoCr trays (N=59) [Vanguard=29, Attune=4 and PFC=26]. These were analysed using peer-reviewed [coordinate-measuring-machine (CMM)] methodology to measure the volumetric wear of the polyethylene (PE) bearing surfaces and trays. The trays were analysed using 2D-profilometry (surface roughness-Ra) and 4D-microscopy. Histological and blood metal ion concentration analyses were performed. Results. The median(IQR) PE wear rate was 10(6to20) mm3/year. Microscopic analysis identified pitting on superior surface of 36(49%) trays. Ra [median (IQR)] of superior surface of pitted trays [0.076 (0.060–0.084) µm] showed a statistically significant increase (p<0.001) compared with unpitted trays [0.057(0.049–0.066) µm]. 4D-microscopy and CMM analysis estimated wear volumes of up to 2mm3 secondary to pitting. The median (range) Co and Cr concentrations were 2.5µg/l (0.2–69.4) and 1.7µg/l (0.5–12.5) respectively in 40 patients. Of the tissue samples examined in 30 patients,6 had at-least “mild”-ALVAL infiltrate. All corresponding “ALVAL” explants were found to be pitted and/or show evidence of loosening of the tray. Conclusion. This study provides further evidence that CoCr release in TKR appears to be an under-recognised cause of adverse clinical outcomes. Gross metal ion elevations occurred in association with micromotion/loosening of the tray

The periclavicular space is a conduit for the brachial plexus and subclavian-axillary vascular system. Changes in its shape/form generated by alteration in the anatomy of its bounding structures, e.g. clavicle malunion, cause distortion of the containing structures, particularly during arm motion, leading to syndromes of thoracic outlet stenosis etc., or alterations of scapular posture with potential reduction in shoulder function. Aim of this study was developing an in vitro methodology for systematic and repeatable measurements of the clinically poorly characterized periclavicular space during arm motion using CT-imaging and computer-aided 3D-methodologies. A radiolucent frame, mountable to the CT-table, was constructed to fix an upper torso in an upright position with the shoulder joint lying in the isocentre. The centrally osteotomized humerus is fixed to a semi-circular bracket mounted centrally at the end of the frame. All arm movements (ante-/retroversion, abduction/elevation, in-/external rotation) can be set and scanned in a defined and reproducible manner. Clavicle fractures healed in malposition can be simulated by osteotomy and fixation using a titanium/carbon external fixator. During image processing the first rib served as fixed reference in space. Clavicle, scapula and humerus were registered, segmented, and triangulated. The different positions were displayed as superimposed surface meshes and measurements performed automatically. Initial results of an intact shoulder girdle demonstrated that different arm positions including ante-/retroversion and abduction/elevation resulted solely in a transverse movement of the clavicle along/parallel to the first rib maintaining the periclavicular space. A radiolucent frame enabling systematic and reproducible CT scanning of upper torsos in various arm movements was developed and utilized to characterize the effect on the 3D volume of the periclavicular space. Initial results demonstrated exclusively transverse movement of the clavicle along/parallel to the first rib maintaining the periclavicular space during arm positions within a physiological range of motion

Introduction. There is no doubt that the future of limb lengthening lies with internal lengthening. Complication rates are reduced and patient satisfaction is increased. The evolution of internal lengthening peaked with the dual direction, easily inserted and externally controlled PRECICE Nail. It has excelled in performance in accuracy and satisfaction. Its versatility increased with smaller sizes and increased excursion. A field safety notice was issued was issued in October 2021 by the parent company NuVasive. The advice was monitoring of current cases and a hold on implantation until after a review of process. At the National Orthopaedic Hospital Cappagh we elected to remove all implanted nails and assess the nail integrity and physiological changes associated with implantation. Materials & Methods. All patients in who a retained Precice nail at the time of the field safety notice were identified. Patients and families were contacted to explain the issued safety notice from the company and explain that we would be scheduling them for nail removal. This was part of our standard care but we prioritised this group on our waiting list. Consent was obtained for nail removal but also for histological assessment of canal scrapings, blood ion level analysis and independent assessment of the retrieved nail by our academic collaborators at University College Dublin. Ion levels were then repeated at an interval post removal with consent. Results. We identified 7 Precice nails in 5 patients still implanted. All patients had consolidated after lengthening and were ready for nail removal. Elevated Titanium blood ion levels were identified at the time of retrieval. Histological abnormalities consistent with metalosis were identified. In all cases the nail was grossly intact and examination of the motor showed no evidence of wear or failure. Follow up ion levels obtained post retrieval showed persistent elevation. Conclusions. Our retrieval audit shows persistent elevation of Titanium ion levels and abnormal histology despite apparent nail integrity. These findings require further evaluation in a larger retrieval series to determine if there is a high incidence of this phenomenon and if ion levels have a clinical effect

Aims. The scapula is a rare site for a primary bone tumour. Only a small number of series have studied patient outcomes after treatment. Previous studies have shown a high rate of recurrence, with functional outcomes determined by the preservation of the glenohumeral joint and deltoid. The purpose of the current study was to report the outcome of patients who had undergone tumour resection that included the scapula. Methods. We reviewed 61 patients (37 male, 24 female; mean age 42 years (SD 19)) who had undergone resection of the scapula. The most common resection was type 2 (n = 34) according to the Tikhoff-Linberg classification, or type S1A (n = 35) on the Enneking classification. Results. The ten-year disease-specific survival was 76%. High tumour grade (hazard ratio (HR) 4.27; p = 0.016) and a total resection of the scapula (HR 3.84; p = 0.015) were associated with worse survival. The ten-year metastasis-free and local recurrence-free survivals were 82% and 86%, respectively. Total scapular resection (HR 6.29; p = 0.004) was associated with metastatic disease and positive margins were associated with local recurrence (HR 12.86; p = 0.001). At final follow-up, the mean shoulder forward elevation and external rotation were 79° (SD 62°) and 27° (SD 25°), respectively. The most recent functional outcomes evaluated included the mean Musculoskeletal Tumor Society Score (76% (SD 17%)), the American Shoulder and Elbow Score (73% (SD 20%)), and the Simple Shoulder Test (7 (SD 3)). Preservation of the glenoid (p = 0.001) and scapular spine (p < 0.001) improved clinical outcomes; interestingly, preservation of the scapular spine without the glenoid improved outcomes (p < 0.001) compared to preservation of the glenoid alone (p = 0.05). Conclusion. Resection of the scapula is a major undertaking with an oncological outcome related to tumour grade, and a functional outcome associated with the status of the scapular spine and glenoid. Positive resection margins are associated with local recurrence. Cite this article: Bone Joint J 2023;105-B(12):1314–1320

Aims. Traditionally, total hip arthroplasty (THA) templating has been performed on anteroposterior (AP) pelvis radiographs. Recently, additional AP hip radiographs have been recommended for accurate measurement of the femoral offset (FO). To verify this claim, this study aimed to establish quantitative data of the measurement error of the FO in relation to leg position and X-ray source position using a newly developed geometric model and clinical data. Methods. We analyzed the FOs measured on AP hip and pelvis radiographs in a prospective consecutive series of 55 patients undergoing unilateral primary THA for hip osteoarthritis. To determine sample size, a power analysis was performed. Patients’ position and X-ray beam setting followed a standardized protocol to achieve reproducible projections. All images were calibrated with the KingMark calibration system. In addition, a geometric model was created to evaluate both the effects of leg position (rotation and abduction/adduction) and the effects of X-ray source position on FO measurement. Results. The mean FOs measured on AP hip and pelvis radiographs were 38.0 mm (SD 6.4) and 36.6 mm (SD 6.3) (p < 0.001), respectively. Radiological view had a smaller effect on FO measurement than inaccurate leg positioning. The model showed a non-linear relationship between projected FO and femoral neck orientation; at 30° external neck rotation (with reference to the detector plane), a true FO of 40 mm was underestimated by up to 20% (7.8 mm). With a neutral to mild external neck rotation (≤ 15°), the underestimation was less than 7% (2.7 mm). The effect of abduction and adduction was negligible. Conclusion. For routine THA templating, an AP pelvis radiograph remains the gold standard. Only patients with femoral neck malrotation > 15° on the AP pelvis view, e.g. due to external rotation contracture, should receive further imaging. Options include an additional AP hip view with elevation of the entire affected hip to align the femoral neck more parallel to the detector, or a CT scan in more severe cases. Cite this article: Bone Jt Open 2022;3(10):795–803

Aims. This study aimed to investigate the role and mechanism of meniscal cell lysate (MCL) in fibroblast-like synoviocytes (FLSs) and osteoarthritis (OA). Methods. Meniscus and synovial tissue were collected from 14 patients with and without OA. MCL and FLS proteins were extracted and analyzed by liquid chromatography‒mass spectrometry (LC‒MS). The roles of MCL and adenine nucleotide translocase 3 (ANT3) in FLSs were examined by enzyme-linked immunosorbent assay (ELISA), flow cytometry, immunofluorescence, and transmission electron microscopy. Histological analysis was performed to determine ANT3 expression levels in a male mouse model. Results. We discovered for the first time that MCL was substantially enriched in the synovial fluid of OA patients and promoted the release of inflammatory cytokines from FLSs through MCL phagocytosis. Through LC‒MS, ANT3 was identified and determined to be significantly upregulated in MCL and OA-FLSs, corresponding to impaired mitochondrial function and cell viability in OA-FLSs. Mitochondrial homeostasis was restored by ANT3 suppression, thereby alleviating synovial inflammation. Furthermore, elevated ANT3 levels inhibited ERK phosphorylation. Specifically, silencing ANT3 prevented inhibition of ERK phosphorylation and significantly reduced the elevation of reactive oxygen species (ROS) and JC1 membrane potential in MCL-induced synovial inflammation. Conclusion. This study revealed the important roles of MCL and ANT3 in FLS mitochondria. Silencing ANT3 rescued ERK phosphorylation, thereby restoring mitochondrial homeostasis in FLSs and alleviating synovitis and OA development, offering a potential target for treating synovitis and preventing early-stage OA. Cite this article: Bone Joint Res 2023;12(4):274–284

Osteosynthesis of high-energy metaphyseal proximal tibia fractures is still challenging, especially in patients with severe soft tissue injuries and/or short stature. Although the use of external fixators is the traditional treatment of choice for open comminuted fractures, patients' acceptance is low due to the high profile and therefore the physical burden of the devices. Recently, clinical case reports have shown that supercutaneous locked plating used as definite external fixation could be an efficient alternative. Therefore, the aim of this study was to evaluate the effect of implant configuration on stability and interfragmentary motions of unstable proximal tibia fractures fixed by means of externalized locked plating. Based on a right tibia CT scan of a 48 years-old male donor, a finite element model of an unstable proximal tibia fracture was developed to compare the stability of one internal and two different externalized plate fixations. A 2-cm osteotomy gap, located 5 cm distally to the articular surface and replicating an AO/OTA 41-C2.2 fracture, was virtually fixed with a medial stainless steel LISS-DF plate. Three implant configurations (IC) with different plate elevations were modelled and virtually tested biomechanically: IC-1 with 2-mm elevation (internal locked plate fixation), IC-2 with 22-mm elevation (externalized locked plate fixation with thin soft tissue simulation) and IC-3 with 32-mm elevation (externalized locked plate fixation with thick soft tissue simulation). Axial loads of 25 kg (partial weightbearing) and 80 kg (full weightbearing) were applied to the proximal tibia end and distributed at a ratio of 80%/20% on the medial/lateral condyles. A hinge joint was simulated at the distal end of the tibia. Parameters of interest were construct stiffness, as well as interfragmentary motion and longitudinal strain at the most lateral aspect of the fracture. Construct stiffness was 655 N/mm (IC-1), 197 N/mm (IC-2) and 128 N/mm (IC-3). Interfragmentary motions under partial weightbearing were 0.31 mm (IC-1), 1.09 mm (IC-2) and 1.74 mm (IC-3), whereas under full weightbearing they were 0.97 mm (IC-1), 3.50 mm (IC-2) and 5.56 mm (IC-3). The corresponding longitudinal strains at the fracture site under partial weightbearing were 1.55% (IC-1), 5.45% (IC-2) and 8.70% (IC-3). From virtual biomechanics point of view, externalized locked plating of unstable proximal tibia fractures with simulated thin and thick soft tissue environment seems to ensure favorable conditions for callus formation with longitudinal strains at the fracture site not exceeding 10%, thus providing appropriate relative stability for secondary bone healing under partial weightbearing during the early postoperative phase

Aims. Head-taper corrosion is a cause of failure in total hip arthroplasty (THA). Recent reports have described an increasing number of V40 taper failures with adverse local tissue reaction (ALTR). However, the real incidence of V40 taper damage and its cause remain unknown. The aim of this study was to evaluate the long-term incidence of ALTR in a consecutive series of THAs using a V40 taper and identify potentially related factors. Methods. Between January 2006 and June 2007, a total of 121 patients underwent THA using either an uncemented (Accolade I, made of Ti. 12. Mo. 6. Zr. 2. Fe; Stryker, USA) or a cemented (ABG II, made of cobalt-chrome-molybdenum (CoCrMo); Stryker) femoral component, both with a V40 taper (Stryker). Uncemented acetabular components (Trident; Stryker) with crosslinked polyethylene liners and CoCr femoral heads of 36 mm diameter were used in all patients. At a mean folllow-up of 10.8 years (SD 1.1), 94 patients (79%) were eligible for follow-up (six patients had already undergone a revision, 15 had died, and six were lost to follow-up). A total of 85 THAs in 80 patients (mean age 61 years (24 to 75); 47 (56%) were female) underwent clinical and radiological evaluation, including the measurement of whole blood levels of cobalt and chrome. Metal artifact reduction sequence MRI scans of the hip were performed in 71 patients. Results. A total of 20 ALTRs were identified on MRI, with an incidence of 26%. Patients with ALTR had significantly higher median Co levels compared with those without ALTR (2.96 μg/l (interquartile range (IQR) 1.35 to 4.98) vs 1.44 μg/l (IQR 0.79 to 2.5); p = 0.019). Radiological evidence of osteolysis was also significantly associated with ALTR (p = 0.014). Median Cr levels were not significantly higher in those with ALTR compared with those without one (0.97 μg/l (IQR 0.72 to 1.9) v 0.67 μg/l (IQR 0.5 to 1.19; p = 0.080). BMI, sex, age, type of femoral component, head length, the inclination of the acetabular component, and heterotopic ossification formation showed no significant relationship with ALTR. Conclusion. Due to the high incidence of local ALTR in our cohort after more than ten years postoperatively, we recommend regular follow-up investigation even in asymptomatic patients with V40 taper and metal heads. As cobalt levels correlate with ALTR occurrence, routine metal ion screening and consecutive MRI investigation upon elevation could be discussed. Cite this article: Bone Joint J 2022;104-B(7):852–858

Introduction. Surgeons commonly resect additional distal femur during primary total knee arthroplasty (TKA) to correct a flexion contracture to restore range of motion and knee function. However, the effect of joint line elevation on the resulting TKA kinematics including frontal plane laxity is unclear. Thus, our goal was to quantify the effect of additional distal femoral resection on passive extension and mid-flexion laxity. Methods. Six computational knee models with capsular and collateral ligament properties specific to TKA were developed and implanted with a contemporary posterior-stabilized TKA. A 10° flexion contracture was modeled by imposing capsular contracture as determined by simulating a common clinical exam of knee extension and accounting for the length and weight of each limb segment from which the models were derived (Figure 1). Distal femoral resections of 2 mm and 4 mm were simulated for each model. The knees were then extended by applying the measured knee moments to quantify the amount of knee extension. The output data were compared with a previous cadaveric study using a two-sample two-tailed t-test (p<0.05) [1]. Subsequently, varus and valgus torques of ±10 Nm were applied as the knee was flexed from 0° to 90° at the baseline, and after distal resections of 2 mm, and 4 mm. Coronal laxity, defined as the sum of varus and valgus angulation in response to the applied varus and valgus torques, was measured at 30° and 45°of flexion, and the flexion angle was identified where the increase in laxity was the greatest with respect to baseline. Results. With 2 mm and 4 mm of distal femoral resection, the knee extended an additional 4°±0.5° and 8°±0.75°, respectively (Figure 2). No significant difference was found between the extension angle predicted by the six models and the results of the cadaveric study after 2 mm (p= 0.71) and 4 mm (p= 0.47). At 2 mm resection, mean coronal laxity increased by 3.1° and 2.7° at 30° and 45°of flexion, respectively. At 4 mm resection, mean coronal laxity increased by 6.5° and 5.5° at 30° and 45° of flexion, respectively (Figures 3a and 3b). The flexion angle corresponding to the greatest increase in coronal laxity for 2 mm of distal resection occurred at 22±7° of flexion with a mean increase in laxity of 4.0° from baseline. For 4 mm distal resection, the greatest increase in coronal laxity occurred at 16±6° of flexion with a mean increase in laxity of 7.8° from baseline. Conclusion. A TKA computational model representing a knee with preoperative flexion contracture was developed and corroborated measures from a previous cadaveric study [1]. While additional distal femoral resection in primary TKA increases passive knee extension, the consequent joint line elevation induced up to 8° of additional coronal laxity in mid-flexion. This additional midflexion laxity could contribute to midflexion instability; a condition that may require TKA revision surgery. Further studies are warranted to understand the relationship between joint line elevation, midflexion laxity, and instability. For any figures or tables, please contact the authors directly

Aims. The use and variety of stemless humeral components in anatomical total shoulder arthroplasty (TSA) have proliferated since their advent in 2004. Early outcomes are reassuring but independent mid-term results are scarce. This independent study reports a consecutive series of 143 Eclipse stemless shoulder prostheses with a minimum five-year (5 to 10) follow-up. Methods. Outcomes of 143 procedures undertaken for all indications in 131 patients were reviewed, with subset analysis of those for osteoarthritis (OA) (n = 99). The primary outcome was the Oxford Shoulder Score (OSS) at a minimum of five years. Secondary outcomes were ranges of motion and radiological analysis of humeral radiolucency, rotator cuff failure, and glenoid loosening. Results. Mean OSS at mean follow-up of 6.67 years (5.0 to 10.74) was 40.12 (9 to 48), with no statistically significant difference between those implanted for a non-OA indication and those for OA (p = 0.056) or time-dependent deterioration between two years and five years (p = 0.206). Ranges of motion significantly improved compared with preoperative findings and were maintained between two and five years with a mean external rotation of 38° (SD 18.1, 0 to 100) and forward elevation of 152° (SD 29.9, 90 to 180). Of those components with radiographs suitable for analysis (n = 83), 23 (28%) were found to have a least one humeral radiolucent line, which were predominantly incomplete, less than 2 mm, and in a single anatomical zone. No humeral components were loose. A radiolucent line was present around 22 (15%) of glenoid components, and 15 (10%) of components had failed. Rotator cuff failure was found in 21 (15%) components. The mean time to either glenoid or rotator cuff failure was greater than three years following implantation. Survivorship was 96.4% (95% CI 91.6 to 98.5, number at risk 128) at five years, and 94.3% (95% CI 88.2 to 97.3, number at risk 76) at seven years, both of which compare favourably with best results taken from available registries. Conclusion. Functional and radiological outcomes of the Eclipse stemless TSA are excellent, with no loose humeral components at minimum five-year follow-up. The presence of radiolucent lines is of interest and requires long-term observation but does not impact on the clinical results. Of the eight revisions required, this was predominantly for glenoid and rotator cuff failure. Cite this article: Bone Joint J 2022;104-B(1):83–90

Osteoarthritis, the most common degenerative joint disease, significantly impairs life quality and labor capability of patients. Synovial inflammation, initiated by HMGB1 (High mobility group box 1)-induced activation of macrophage, precedes other pathological changes. As an upstream regulator of NF-κB (nuclear factor-kappa B) and MAPK (mitogen-activated protein kinase) signaling pathway, TAK1 (TGF-β activated kinase 1) participates in macrophage activation, while its function in osteoarthritis remains unveiled. This study aims to investigate the role of TAK1 in the pathogenesis of osteoarthritis via both in vitro and in vivo approaches. We performed immunohistochemical staining for TAK1 in synovial tissue, both in osteoarthritis patients and healthy control. Besides, immunofluorescence staining for F4/80 as macrophage marker and TAK1 were conducted as well. TAK1 expression was examined in RAW264.7 macrophages stimulated by HMGB1 via qPCR (Quantitative polymerase chain reaction) and Western blotting, and the effect of TAK1 inhibitor (5z-7 oxozeaenol) on TNF-α production was evaluated by immunofluorescence staining. Further, we explored the influence of intra-articular shRNA (short hairpin RNA) targeting TAK1 on collagenase-induced osteoarthritis in mice. Immunohistochemical staining confirmed significant elevation of TAK1 in osteoarthritic synovium, and immunofluorescence staining suggested macrophages as predominant residence of TAK1. In HMGB1-stimulated RAW264.7 macrophages, TAK1 expression was up-regulated both in mRNA and protein level. Besides, TAK1 inhibitor significantly impairs the production of TNF-α by macrophages upon HMGB1 stimulation. Moreover, intra-articular injection of lentivirus loaded with shRNA targeting TAK1 (sh-TAK1) reduced peri-articular osteophyte formation in collagenase-induced osteoarthritis in mice. TAK1 exerts a potent role in the pathogenesis of osteoarthritis by mediating the activation of macrophages

The purpose of this randomized controlled trial was to evaluate serum metal levels in patients undergoing total hip arthroplasty (THA) with a conventional compared to a modular dual-mobility bearing. Patients undergoing primary THA for osteoarthritis were randomized to receive either a modular dual-mobility or conventional polyethylene bearing. All patients received the same titanium acetabular and femoral component and a ceramic femoral head. Serum metal levels were drawn pre-operatively then annually for a minimum of two years postoperatively. An a priori power analysis determined that 40 patients (20 per cohort) were needed to identify a clinically relevant difference in serum cobalt of 0.35 ng/ml (ppb) at 90% power. Forty-six patients were randomized to a modular dual-mobility (n=25) or conventional bearing (n=21) with 40 at a minimum follow-up of two years. No differences in serum cobalt (mean 0.14 ppb [range, 0.075–0.29] vs. 0.20 ppb [range, 0.075–0.57], p=0.39) or chromium levels (mean 0.14 ppb [range, 0.05–0.50] vs. 0.12 ppb [range, 0.05–0.35], p=0.65) were identified between the modular dual-mobility and conventional cohorts, respectively. There was no statistically significant difference in serum Co or Cr at two years postoperatively in subjects implanted with a ceramic head and this particular dual mobility bearing in comparison to a ceramic head and a conventional acetabular component. While modest expected elevations in serum Co and Cr were observed in the dual mobility group, in no case did the Co level exceed the laboratory reference range nor the threshold of one part per billion that has been associated with adverse local tissue reactions to mechanically-assisted crevice corrosion

In recent years, use of anatomic stemless total shoulder arthroplasty (AsTSA) has increased. Despite evidence to suggest good mid-term results at 2-year follow-up there is a paucity of evidence for longer term follow-up. This study aimed to investigate outcomes at a minimum of 5 years post-operatively following primary AsTSA. This study is a retrospective case series of all patients who underwent a Mathys Affinis AsTSA from July 2010 (first case) to August 2018 (to allow minimum 5-year follow-up). Clinical outcomes included revision rate, range of motion and patient reported outcomes (Oxford Shoulder Score and Numerical Satisfaction Score). Radiological outcome was assessment of radiolucent lines for Lazarus grading. A total of 105 stemless TSAs were implanted. Five patients underwent revision (4.8%). Seventy-five AsTSA's were included in the final study for analysis of 5-year outcomes. Median follow-up time was 6.1 years. Median age was 69 years old and 81% were female. Oxford shoulder score showed a range of 18 to 48, with a median score of 47. Satisfied or very Satisfied was selected in 94.37%. Median range of motion assessments showed forward elevation 160°, abduction 150°, external rotation 40°, and mode internal rotation was to the lumbar spine. No glenoid lucency was present in 79.7%. There were 9.5% with Lazarus Grade 1 lucency, 5.4% with Lazarus Grade 2, and 5.4% Lazarus Grade 3. No humeral lucency was observed. This cohort study demonstrates promising clinical and radiological outcomes for the Mathys Affinis Stemless TSA at minimum 5 years post-operatively

Objectives. Because there have been no standard methods to determine pre-operatively the thickness of resection of the proximal tibia in unicompartmental knee arthroplasty (UKA), information about the relationship between the change of limb alignment and the joint line elevation would be useful for pre-operative planning. The purpose of this study was to clarify the correlation between the change of limb alignment and the change of joint line height at the medial compartment after UKA. Methods. A consecutive series of 42 medial UKAs was reviewed retrospectively. These patients were assessed radiographically both pre- and post-operatively with standing anteroposterior radiographs. The thickness of bone resection at the proximal tibia and the distal femur was measured radiographically. The relationship between the change of femorotibial angle (δFTA) and the change of joint line height, was analysed. Results. The mean pre- and post-operative FTA was 180.5° (172.2° to 184.8°) and 175.0° (168.5° to 178.9°), respectively. The mean δFTA was 5.5° (2.3° to 10.1°). The joint line elevation of the tibia (JLET) was 4.4 mm (2.1 to 7.8). The δFTA was correlated with the JLET (correlation coefficient 0.494, p = 0.0009). Conclusions. This study indicated that there is a significant correlation between the change of limb alignment and joint line elevation. This observation suggests that it is possible to know the requirement of elevation of the joint line to obtain the desired correction of limb alignment, and to predict the requirement of bone resection of the proximal tibia pre-operatively. Cite this article: Bone Joint Res 2015;4:128–133

Patients awaiting resolution of swelling and oedema prior to ankle surgery can represent a significant burden on hospital beds. Our study assessed whether external pneumatic intermittent compression (EPIC) can reduce delays to surgery. Our prospective randomised controlled trial (n= 20) compared outcomes of patients treated with EPIC vs control group managed with ice and elevation. Included were patients aged <18 years with isolated closed ankle fractures admitted for management of swelling prior to surgery. Excluded were open fractures, injuries to contralateral leg, diabetes, absent pulses, peripheral vascular disease, inability to consent, no requirement for admission. Eligible patients were randomised to active or control arms. All patients were managed initially with reduction and back slab application. Patients in active arm fitted with EPIC (Hydroven 3000) device over the back slab. Assessment by treating team determined the time at which patient is assessed ready for surgery. Patients in the treatment arm were assessed as ready for surgery sooner, (123 hrs vs 168hrs, T score = 1.925, P 0.035) and had a shorter time to surgery (167 hrs vs 216 hrs, T score = 1.748, P 0.047) Length of stay was reduced bud did not reach statistical significance. (259 hrs vs 269 hrs, T score 0.229, P 0.41). Our results showed a statistically and clinically significant reduction in time that patients were assessed ready for surgery and time to surgery in the treatment cohort. We conclude that although further data is needed to achieve an adequately powered study and assess the safety profile of the EPIC, incorporation of EPIC into routine clinical practice has the potential for significant cost savings

Aims. This study compared patients who underwent arthroscopic repair of large to massive rotator cuff tears (LMRCTs) with isolated incomplete repair of the tear and patients with incomplete repair with biceps tendon augmentation. We aimed to evaluate the additional benefit on clinical outcomes and the capacity to lower the re-tear rate. Methods. We retrospectively reviewed 1,115 patients who underwent arthroscopic rotator cuff repair for full-thickness tears between October 2011 and May 2019. From this series, we identified 77 patients (28 male, 49 female) with a mean age of 64.1 years (50 to 80). Patients were classified into groups A (n = 47 incomplete) and B (n = 30 with biceps augmentation) according to the nature of their reconstruction. Clinical scores were checked preoperatively and at six months, one year, and two years postoperatively. In preoperative MRI, we measured the tear size, the degree of fatty infiltration, and muscle volume ratio of the supraspinatus. In postoperative MRI, the integrity of the repaired rotator cuff tendon was assessed using the Sugaya classification. Tendon thickness at the footprint was evaluated on T2-weighted oblique coronal view. Results. There were no significant differences in the initial preoperative demographic characteristics. In both groups, there were significant improvements in postoperative clinical scores (p < 0.001). However, most clinical outcomes, including range of motion measurements (forward elevation, external rotation, internal rotation, and abduction), showed no differences between the pre- and postoperative values. Comparing the postoperative outcomes of both groups, no further improvement from biceps augmentation was found. Group B, although not reaching statistical significance, had more re-tears than group A (30% vs 15%; p = 0.117). Conclusion. In LMRCTs, biceps augmentation provided no significant improvement of an incomplete repair. Therefore, biceps augmentation is not recommended in the treatment of LMRCTs. Cite this article: Bone Joint J 2022;104-B(11):1234–1241

The Canadian Cardiovascular Society (CCS) recommends performing daily troponin testing on postoperative days 0 through 3 for noncardiac surgical patients to decrease the mortality rate due to myocardial injury. Indications for testing include:. ->65 yo. -45-64 yo with significant cardiovascular disease. -a Revised Cardiac Risk Index score (RCRI) > 1. Troponin elevation > 30 ng/L is termed “myocardial injury after noncardiac surgery” (MINS). The study objective was to determine the prognostic relevance of applying CCS recommendations. 669 patients undergoing THA were included in the study. Based on the CCS recommendation there were 4 patient Groups depending on whether or not they met the MINS screening protocol criteria and whether or not it was applied:. -A - met & applied (n=181). -B - met & not applied (n=248). -C – not met & applied (n=10). -D – not met & not applied (n=230). 307 (45.8%) males and 363 (54.2%) females with an average age of 67.8 years were included. Group A- 24% incidence (43 patients) of troponin rise & 5% incidence (9 patients) of cardiac complications. Group B- 0.4% incidence (1 patient) of cardiac complications. Groups A + B – representing all patients who should have had the MINS screening protocol applied according to the CCS recommendations − 10 (2.3%) patients developed cardiac complication and one (0.2%) patient death. MINS screening protocol group (A & C) LOS was 4.0 days compared to 1.4 days for those not screened (p-value: <0.001). Applying the CCS MINS screening protocol to elective THA patients added no benefit in predicting/preventing postoperative cardiac events but was associated with a significant increase in LOS. Following current CCS recommendations without more specifications and clinical evidence is unwarranted

This paper presents an ongoing review of the use of a wedge-shaped porous metal augments in the shoulder to address glenoid retroversion as part of anatomical total shoulder arthroplasty (aTSA). Seventy-five shoulders in 66 patients (23 women and 43 men, aged 42 to 85 years) with Walch grade B2 or C glenoids underwent porous metal glenoid augment (PMGA) insertion as part of aTSA. Patients received either a 15º or 30º PMGA wedge (secured by screws to the native glenoid) to correct excessive glenoid retroversion before a standard glenoid component was implanted using bone cement. Neither patient-specific guides nor navigation were used. Patients were prospectively assessed using shoulder functional assessments (Oxford Shoulder Score [OSS], American Shoulder and Elbow Standardized Shoulder Assessment Form [ASES], visual analogue scale [VAS] pain scores and forward elevation [FE]) preoperatively, at three, six, and 12 months, and yearly thereafter, with similar radiological surveillance. Forty-nine consecutive series shoulders had a follow-up of greater than 24 months, with a median follow-up of 48 months (range: 24–87 months). Median outcome scores improved for OSS (21 to 44), ASES (24 to 92), VAS (7 to 0), and FE (90º to 140º). Four patients died, but no others were lost to follow-up. Apart from one infection at 18 months postoperatively and one minor peg perforation, there were no complications, hardware failures, implant displacements, significant lucency or posterior re-subluxations. Radiographs showed good incorporation of the wedge augment with correction of glenoid retroversion from median 22º (13º to 46º) to 4º. All but four glenoids were corrected to within the target range (less than 10º retroversion). The porous metal wedge-shaped augments effectively addressed posterior glenoid deficiency as part of aTSA for rotator cuff intact osteoarthritis, producing satisfactory clinical outcomes with no signs of impending future failure

Abstract. Introduction. The Wells score is commonly used to assess the risk of proximal Deep Vein Thrombosis (DVT) following Knee Arthroplasty (KA). The National Institute for Health and Care Excellence (NICE) guidelines recommend an Ultrasound scan in patients with a Wells score of 2 points or more. We wanted to assess how often this protocol resulted in a scan being done and how many were negative. Methodology. Details of all postoperative Ultrasound scans performed up to 90 days were audited in a high-volume unit between 1st January 2016 and 31st December 2020. This included all Lower Limb Arthroplasty patients. Results. Out of a total of 4955 KA (4506 Total Knee Arthroplasty, 449 Unilateral Knee Arthroplasty), 449 (9.1%) had a total of 561 scans, with 17 (3.0%) scans demonstrating a proximal DVT. Thus 97.0% of Ultrasound scans were negative. Conclusion. The present NICE guidelines with the two-Level DVT Wells score are inappropriate for the management of suspected proximal DVT following KA. We propose that swelling that fails to reduce after 4 hours of elevation, or new swelling after a period of recumbent rest, would be more appropriate indications for a scan and negative scans should not be repeated without a change in symptoms. Unless there are pressing clinical indications, therapeutic anticoagulation should not commence in the absence of a diagnosis

Introduction. Frame HI is the #Days for device removal/cm. IM Nail HI is less relevant (31–45 D/cm). Albizzia HI was 33 D/cm (1991–2003). Patients felt fine approximately 1M after end of lengthening (EoL), resuming normal life and sports. This sometimes resulted in implants fractures (e.g. skying before bone fusion). Ideally, the full fusion should occur at the EoL. We decided to shorten the HI to reach this target, optimising all parameters. Materials & Methods. The evolution of care has been monitored over a 32-year clinical experience with a fully weight-bearing nails (Albizzia then G-nail). Monitoring was with X-rays, DEXA, blood bone activity, and in London with special 5G CBCT Scans. We implemented several changes in the Care of patients and measured them according to the ‘Five Principles’ (stability, function, ‘Roads-vascular supply’, ‘Materials-calories’ and ‘Workers-BFC’, with actions on food intake, activity levels and on muscle and bone vascular growths. Results. Preop: training (vascularity, muscle force). Op & Postop: spine morphine, IM sawing preserving BFC, controlled hypo-pressure, low hydration, 50 cm leg elevation, walking, resistance bike, full motion (drainage, muscle reactivation), discharge 3–4h postop (including bilateral). Postop daily intense gym training. POD07-21: Distraction increased to fight non-linear hyper-ossification (44–50 mm gain at POD30) +/- aided by NSAIDs. HI decreased to 12–20D/cm, sometimes 8D/cm with some ‘soft fusion’ during lengthening, hardening within 1W after EoL. Conclusions. The surgeon is not a passive X-rays observer, but has an active role in changing the healing speed and decreasing HI for patient safety. Electro/Magnetic nails (torque 1 Nm) may be clocked by bone fusion, which does not occur with the G-Nail (19 Nm). An holistic vision for patients and treatments at several levels is essential to accelerate bone healing, and to return fast to full normal life, after a short ‘lengthening parenthesis’

Implant fracture of modular revision stems is a major complication after total hip arthroplasty revision (rTHA). Studies looking at specific modular designs report fracture rates of 0.3% to 0.66% whereas fractures of monobloc designs are only reported anecdotally. It is unclear whether the overall re-revision rate of modular designs is higher and if, whether stem fractures or other revision reasons are responsible for this elevation. All revisions within 5 years after implantation of a revision stems (n. 0. =13,900; n. 5. =2506) were analysed using Cox regression with design (modular: n=17, monobloc: n=27), BMI, Sex and Elixhauser Score as independent variables. One stage and two stage revisions were analysed separately (1-stage: modular n= 7,102; monobloc n= 4,542; 2-stage: 1,551 / 704). The revision volume of the hospitals was also considered (low: <20 revisions, medium: 21–50 revisions, high: >50 revisions). For the 1-stage revisions, the re-revision risk after 4 years was 14,3% [13.2%, 15.5%] for monobloc and 17.4% [16.40%, 18.40%] for modular stems (p< 0.001). Stem fracture was the reason for re-revision in 2.4% of the modular (fracture rate 0.42%) and 0.6% of the monobloc revisions. The difference in re-revision rates between the designs was mainly due to differences in dislocation and stem loosening. For the 2-stage revisions, the revision risks for either design were similar (21.7% [18,5%, 25.4%] vs. 23.0% [20.8%, 25.4%]; p=0.05). Patient characteristics influenced the comparison between the two designs in the 1-stage group but very little in the 2-stage group. Modular revision stem fractures only contribute very minor to re-revision risk. In 2-stage revisions, no difference in overall re-revision rates between designs was observed. This might indicate that the differences observed for 1-stage procedures are due to differences between the patient cohorts, not reflected by the parameters available or surgeon choice

Prompt mobilisation after the Fracture neck of femur surgery is one of the important key performance index (‘KPI caterpillar charts’ 2021) affecting the overall functional outcome and mortality. Better control of peri-operative blood pressure and minimal alteration of renal profile as a result of surgery and anaesthesia may have an implication on early post-operative mobilisation. Aim was to evaluate perioperative blood pressure measurements (duration of fall of systolic BP below the critical level of 90mmHg) and effect on the post-operative renal profile with the newer short acting spinal anaesthetic agent (prilocaine and chlorprocaine) used alongside the commonly used regional nerve block. 20 patients were randomly selected who were given the newer short acting spinal anaesthetic agent along with a regional nerve block between May 2019 and February 2020. Anaesthetic charts were reviewed from all patients for data collection. The assessment criteria for perioperative hypotension: Duration of systolic blood pressure less than 90 mm of Hg and change of pre and post operative renal functions. Only one patient had a significant drop in systolic BP less than 90mmHg (25 minutes). 3 other patients had a momentary fall of systolic BP of less than 5 minutes. None of the above patients had mortality and had negligible change in pre and post op renal function. Only one patient in this cohort had elevation of post-operative creatinine levels but did not have any mortality. Only 1 patient died on day 3 post operatively who had multiple comorbidities and was under evaluation for GI cancer. Even in this patient the peri-operative blood pressure was well maintained (never below 90mmHg systolic) and post-operative renal function was also shown to have improved (309 pre-operatively to 150 post-operatively) in this patient. The use of short-acting spinal anaesthesia has shown to be associated with a better control of blood pressure and end organ perfusion, less adverse effects on renal function leading to early mobilisation and a more favourable patient outcome with reduced mortality, earlier mobilisation, shorter hospital stay and earlier discharge in this elderly patient cohort

Introduction. Reverse total shoulder arthroplasty (RTSA) can partially restore lost range of motion (ROM). Active motion restoration is largely a function of RTSA joint constraint, limiting impingement, and muscle recruitment; however, it may also be a function of implant design. The aim of this computational study was to examine the effects of implant design parameters, such as neck-shaft (N-S) angle and glenoid lateralization, on impingement-free global circumduction range of motion (GC-ROM). GC-ROM summarizes the characteristically complex, wide-ranging envelope of glenohumeral motion into a single quantity for ease of comparison. Methods. Nine computational models were used to investigate implant parameters. The parameters examined were N-S angles of 135°, 145°, and 155° in combination with glenoid lateralizations (0, 5, and 10 mm). Static positioning of the humerus was defined by an elevation direction angle, elevation angle, and rotation. The humerus was rotated from the neutral position (0° of rotation and elevation), and then elevated in different elevation directions until impingement was detected. Abduction occurred at an elevation direction angle of 0°, while flexion and extension occurred at elevation direction angles of 90° and −90°, respectively. Elevation direction angles ranged from −180° to 180°. Elevation ranged from 0° and 180°. Rotations ranged from −45° to 90°, where negative and positive rotations represented external and internal rotation, respectively. For each rotation angle, a plot of maximum elevation in each elevation plane was created using polar coordinates (radius = elevation, angle = elevation direction). The area enclosed by the resulting points, normalized with respect to the implant with a 145° N-S angle and 5 mm lateralization, was calculated. The sum of these areas defined the GC-ROM. Results. Figure 1 depicts the maximum ROM curves at each angle of rotation for a 145° N-S angle humeral implant with 5 mm of glenoid lateralization. Table 1 shows the normalized areas within the maximum ROM curves for each implant configuration at each angle of rotation, where 0% indicates that the corresponding angle of rotation could not be achieved without impingement. The effect of varying N-S angle (constant lateralization of 5 mm) and lateralization (constant N-S angle of 145°) is shown for 0° rotation (Figures 2A and 2B, respectively). Conclusions. In general, increasing glenoid lateralization increases GC-ROM; however, the unintuitive poor performance of all 10 mm lateralized configurations at rotations of −90° highlights the complex relationships between implant parameters and ROM. Interestingly, the 135° N-S implant had greater flexion and extension ROM, while the 155° N-S implant had greater abduction ROM, suggesting that there are trade-offs between N-S angles pertaining to the elevation direction in which maximum elevation is obtained. The results of this study highlight the need to incorporate multi-directional motion when assessing the effect of varying implant parameters on the impingement-free GC-ROM. Future studies will include the application of the presented technique to a broader range of implant and surgical parameters

Displaced proximal humerus fractures remain a difficult clinical problem, and techniques as diverse as percutaneous pinning, locked plating, intramedullary nailing, and shoulder arthroplasty have been proposed. In recent years, reverse total shoulder arthroplasty (RTSA) has become a very popular option to fix just about any fracture. However, RTSA is not without risk, with complications ranging from infection, instability, acromial stress fractures, aseptic loosening, notching and more. In a 2017 study on 39 patients, Tokish et al. compared non-operative treatment to reverse shoulder arthroplasty for displaced 3- and 4-part fractures. There was no difference in pain, range of motion or outcome scores between the two groups. Among the patients who underwent RTSA, there was no difference between early (<30 days) and late (>30 days) surgery suggesting that it could be safe to attempt a non-operative trial in most patients and see how they do. This is also supported by a 2016 study by Sanchez-Sotelo et al. in which they compared 18 patients with primary RTSA to 26 patients with failed ORIF who underwent salvage RTSA. There was no difference in ASES score, ROM and overall satisfaction between both groups suggesting that an ORIF can be attempted in many patients without the fear of compromising a revision RTSA. And although RTSA may provide more predictable results, in a properly selected patient, a well-executed hemiarthroplasty can outperform an RTSA. In a study from Molé et al., 38 patients were randomised to either RTSA or to a hemiarthroplasty. In the hemiarthroplasty group, half of the patients had <90 degrees of forward elevation and half the patients had >120 degrees of forward elevation showing a bi-modal distribution dependent on tuberosity healing. In the RTSA group, however, while having an average of 115 degrees of forward elevation, 68% of patients had less than 120 degrees of forward elevation. While RTSA is a great tool to treat complex displaced comminuted fractures in elderly patients with poor bone quality, it should not be blindly applied to all fractures types and all patients

Aims. Existing literature indicates that inferiorly inclined glenoid baseplates following reverse total shoulder arthroplasty (RSA) produce better outcomes compared to superiorly inclined baseplates. We aim to compare clinical outcomes for RSAs with superiorly and neutrally/inferiorly inclined lateralized glenospheres. Methods. We retrospectively reviewed 154 consecutive patients undergoing RSA between July 2015 and July 2017 by one single-fellowship trained surgeon (AJ). Two raters (KAM and MVS) independently measured glenoid inclination in preoperative and minimum two year follow-up radiographs (anteroposterior/Grashey) using the RSA angle. Inclination was then compared to patient-reported outcomes, range of motion (ROM), and independently assessed degree of scapular notching and staging of heterotopic ossification at two year follow-up. Results. Median postoperative inclination for each group was found to be -3.6° (interquartile range (IQR) -2.1 to -6.9) and 6.0° (3.2° to 10.1°) for the neutrally/inferiorly and superiorly inclined cohorts, respectively. Preoperative inclination was highly associated with postoperative inclination (p = 0.004). When comparing superiorly and neutrally/inferiorly inclined glenospheres, there were no differences in heterotopic ossification (p = 0.606), scapular notching (p = 0.367), American Shoulder and Elbow Surgeons score (p = 0.419), Single Assessment Numeric Evaluation (p = 0.417), Visual Analogue Scale (VAS) pain score (p = 0.290), forward elevation (p = 0.161), external rotation (p = 0.537), or internal rotation (p = 0.656). Conclusion. Compared to neutral and inferior inclination, up to 6° ± 3° of superior glenoid baseplate inclination on a lateralized RSA design produces no differences in postoperative ROM or patient-reported outcomes, and produces similar levels of scapular notching and heterotopic ossification. Additionally, the degree of preoperative inclination represents an important factor in surgical decision-making as it is strongly associated with postoperative inclination. It is important to note that the findings of this study are only reflective of lateralized RSA prostheses. Cite this article: Bone Joint J 2021;103-B(2):360–365

Shoulder arthroplasty, both primary (TSA) and reverse (RTSA), are common interventions for arthritis and cuff tear arthropathy. The effect of shoulder arthroplasty on shoulder motion is of particular interest in assessing the effectiveness of the procedure and the development and biomechanical testing of implants. A comparison of the arthroplasty shoulder to that of the non-operated contralateral shoulder provides insight into how well the reconstruction has restored natural shoulder motion. The purpose of this study was to ascertain the shoulder motion of patients who have undergone shoulder arthroplasty and to compare the motion of the reconstructed and contralateral natural sides. Eleven human subjects (70±9yrs) who had undergone total shoulder arthroplasty wore a custom instrumented shirt for the waking hours of one day. The 3D orientation of each humeral sensor was transformed with respect to the torso to allow for the calculation of humeral elevation and plane of elevation angles. Joint angles for each subject were then discretised, and the operative and contralateral normal (control) shoulders were then compared. The majority of both the arthroplasty and control shoulder elevation motions took place below 80° of elevation, totaling on average 1910±373 and 1887±312 motions per hour, respectively. Conversely, elevations greater than 80° were significantly less with occurrences totaling only 55±31 and 78±41 motions per hour for the arthroplasty and control shoulders, respectively (p<0.01). Both the arthroplasty and control shoulder were at elevations below 80° for 88±7% and 87±7% of the day, respectively. When the total motion of the arthroplasty and non-operative control shoulders were compared, no statistically significant difference was detected (p=0.8), although the non-operated side exhibited marginally more motion than the operated side, an effect which was larger at higher elevation angles (p=0.3). This study provides insight into the effects of shoulder arthroplasty on thoraco-humeral motion and compares it to the non-operative side. Interestingly, there were no significant differences measured between the arthroplasty and the control side, which may demonstrate the effectiveness of reconstruction on restoring natural shoulder motion. It is interesting to note that on average, each shoulder arthroplasty elevated above 80° approximately 55 times per hour, corresponding to just under 330,000 motions per year. Similarly, when elevations greater than 60° are extrapolated, the resulting yearly motions total approximately 1.5 million cycles (Mc), which suggests that the ‘duty cycle’ of the shoulder is similar to the hip, approximated to be between 1–2 Mc per year. Arthroplasty wear simulators should be calibrated to simulate these patterns of motion, and component design may be improved by understanding the kinematics of actual shoulder motion

There are a variety of sizes currently available for reverse total shoulder arthroplasty (RTSA) implant systems. Common sizing options include a smaller 36 to 38 mm or a larger 40 to 42 mm glenosphere, and are typically selected based on surgeon preference or patient size. Previous studies have only evaluated the abduction and adduction range of motion within a single plane of elevation, providing a limited view of the joint's possible range of motion. The purpose of this study was to use computer modeling to evaluate the abduction and adduction range of motion across multiple planes of elevation for a range of glenosphere sizes. Computed tomography images of four cadaveric specimens (age: 54 ± 24 years) were used to obtain the osseous anatomy to be utilised in the model. Solid-body motion studies of the RTSA models were constructed with varying glenosphere diameters of 33, 36, 39, 42, and 45 mm in Solidworks (Dassault Systems, US). The implant components were scaled, while maintaining a consistent centre of rotation. Simulations encompassing the full range of abduction and adduction were conducted for the planes of elevation between −15˚ and 135˚ at 15˚ intervals, with the motion of the humerus being constrained in neutral internal-external rotation throughout all planes. Angles of elevation were obtained utilising the humeral long axis and the RTSA centre of rotation. Statistical analysis was performed using repeated measures ANOVA. Glenosphere diameter was found to significantly affect the adduction range of motion (p=0.043), in which the largest size provided approximately 17˚ more adduction range of motion than the smallest. However, abduction range of motion was not found to be significantly affected through the alteration of glenosphere size (p=0.449). The plane of elevation was not found to significantly affect abduction or abduction (p=0.585 & p=0.225, respectively). Increasing glenosphere diameter resulted in an increased adduction range of motion when averaged across the tested planes of elevation; however the observed influence on abduction was not significant. These are similar to the trends observed in the previous single plane of elevation studies. These findings illustrate the importance of implant sizing related to range of motion. Further studies are required to determine the influence of glenosphere size on internal and external range of motion

Background. Post-operative (postop) lower limb alignment in unicompartmental knee arthroplasty (UKA) has been reported to be an important factor for postop outcomes. Slight under-correction of limb alignment has been recommended to yield a better clinical outcomes than neutral alignment. It is useful if the postop limb alignment can be predicted during surgery, however, little is known about the surgical factors affecting the postop limb alignment in UKA. The purpose of this study was to examine the influence of the medial tibial joint line elevation on postop limb alignment in UKA. Methods. Seventy-four consecutive medial UKAs were enrolled in this study. All the patients received a conventional fixed bearing UKA. Pre-operative (preop) and postop limb alignment was examined using long leg radiograph and lower limb alignment changes were calculated. Femoral and tibial osteotomy thickness were measured during surgery. Medial tibial joint line change was defined as polyethylene thickness minus tibial osteotomy thickness and sawblade thickness (1.27mm). Positive values indicated a tibial joint line elevation. Medial femoral joint line change was defined as femoral distal component thickness (6.5mm) minus femoral distal osteotomy thickness and sawblade thickness. Positive values indicated a femoral joint line reduction. Medial joint distraction width was also calculated by tibial joint line elevation plus femoral joint line reduction. The correlation of lower limb alignment change with polyethylene insert thickness, the medial tibial joint line elevation, femoral joint line reduction, or joint distraction width were analyzed. Results. The mean preop hip-knee-ankle (HKA) angle was 7.1 ± 3.3° in varus and postop was 2.1 ± 3.0° in varus. The mean lower limb alignment change was 5.0 ± 2.6°. The mean polyethylene insert thickness was 8.5 ± 0.8mm, the tibial joint line elevation was 4.4 ± 1.3mm and the medial femoral joint line reduction was 0.0 ± 1.1mm, the joint distraction width was 4.5 ± 1.5mm. The polyethylene insert thickness, the medial tibial joint line elevation, and the joint distraction width were positively correlated with the lower limb alignment change (R=0.27; P<0.05, R=0.47; P<0.001, R=0.53; P<0.001, respectively) (Figure 1a,b,d). There was no correlation between the medial femoral joint line reduction and the lower limb alignment change (Figure 1c). Discussion. The postop limb alignment in total knee arthroplasty (TKA) is determined by the osteotomy angle of the femur and tibia. On the other hand, it has been reported that the postop alignment in UKA is not influenced by the osteotomy angle but by the insert thickness. Our results indicated that the medial tibial joint line elevation and the joint distraction width were more useful to predict lower limb alignment change than the insert thickness itself. Measuring the medial tibial osteotomy thickness during surgery will help surgeon to predict postop lower limb alignment in UKA. For any figures or tables, please contact authors directly (see Info & Metrics tab above).

Introduction and Objective. The Cartilage Oligomeric Matrix Protein (COMP) is a glycoprotein that is elevated in patients with osteoarthritis. The elevation increases linearly with the radiological grade of osteoarthritis. The objective of this study was to study the levels of COMP in knee osteoarthritis in the Indian population and to correlate (establish ranges) with the specific radiological grade of osteoarthritis (Kellgreen and Lawrence grading). Since the radiological classification is subjective, the COMP levels would serve as a more objective way of classifying osteoarthritic joints. Materials and Methods. We analysed the COMP levels by the Enzyme Linked Immunosorbent Assay (ELISA) method in 100 patients presenting to the outpatient clinic of our hospital, after obtaining due approvals. The radiographs of these patients were classified according to the Kellgreen-Lawrence grading by a senior orthopaedic surgeon. Results. We found a linear correlation with the COMP levels and the radiological classification as established in the previous studies. We were also able to establish a range of COMP levels for each classification stage. Conclusions. This study would provide means to classify osteoarthritis without the need for radiographs thus minimising radiation to the patient. It would also help us to predict the radiological findings thus serving as a guide for further treatment planning

Latissimus dorsi anterior to major transfers have been advocated in the setting of loss of external rotation and elevation in conjunction with reverse shoulder replacement. Reverse shoulder replacement is a prosthesis specifically designed for shoulders with poor rotator cuff function. In the vast majority of cases, some teres minor function at the minimum is maintained in shoulders destined for a reverse shoulder replacement. However, in certain circumstances there is complete loss of any external rotation, and a muscle transfer can be performed in order to restore some external rotation function. A reverse shoulder replacement in the absence of any rotator cuff function goes into obligate internal rotation with elevation. A minimum of external rotation strength is necessary in order to maintain the arm in normal rotation. The first tip is patient selection. Physical examination of active external rotation, external rotation strength and forward elevation should be just performed. A latissimus transfer is indicated in patients who cannot maintain their arm in neutral to at least a few degrees of external rotation. A lag sign is another physical examination finding which can indicate complete loss of rotator cuff function. The latissimus dorsi transfer is performed by first identifying and releasing the latissimus from its insertion on the anterior humerus. The arthroplasty is performed. The passage for the latissimus muscle is developed carefully and being mindful of the axillary nerve in particular. The latissimus is directed inferior to the nerve and around the medial and posterior aspect of the proximal humerus. Different ways of securing the transfer to the humerus have been described including bone tunnels and anchors. Often it is easier to place the anchors and/or the bone tunnels prior to inserting the humeral prosthesis. The latissimus is secured in the new position, enabling it to participate in external rotation. The value of this is difficult to clearly establish. Most studies are evidence level IV and there are no good comparative studies in a controlled patient population. This is a good option for shoulders with no active external rotation, but they may increase overall complication rate. Complications include dislocation, infection, and transient nerve palsy

Introduction. The anatomic dual mobility (ADM) technology utilized a monoblock cobalt chromium acetabular component. However, design limitations conferred difficulties controlling orientation during component insertion and inability to confirm full implant seating; the solution resulted in the creation of the modular dual mobility (MDM). The modular implant combines a standard titanium acetabular component and a cobalt chromium liner insert. Due to the metal-on-metal interface on MDM implants, fretting and corrosion releasing metal ions like previous metal-on-metal THA implants, were a concern. This study prospectively reviewed metal ions (cobalt, chromium and titanium) on patients who were at least 1 year post MDM implantation and compared them to patients with an ADM implant and evaluated radiographic seating of the components. Methods. All patients with ADM and MDM implants underwent evaluation of metal ions (cobalt, chromium and titanium) at their one year follow-up appointment. Radiographic evaluation for acetabular polar gaps was performed. Elevated metal ions were determined using standard laboratory ranges. Differences in baseline demographics were assessed using the Mann Whitney-U test and Fishers's exact test. Differences in metal ions and implant type were compared using the Fisher's exact tests. Results. Fifty consecutive patients (25 ADM and 25 MDM were included in the study. All patients in the ADM group were primary THR and all in the MDM group were revision THR. Mean age and BMI were 73 (+/−10) and 26 (+/−4) respectively. A majority of the participants were female (72%), overall mean length of implantation was 1.2 years. We found no difference in metal ion elevation between groups at a minimum of one year post implantation (cobalt, p=1.0, chromium, p=0.49; titanium p=1.0). Within the MDM and ADM cohorts, there were an equal number of patients with mildly elevated cobalt (n=6), as well as mildly elevated titanium (n=1). The ADM cohort had more patients with increased chromium when compared to the MDM cohort (ADM=1 vs MDM=0), but did not reach significance. There was one ADM patient with significantly elevated levels of cobalt and chromium probably related to prior spine fusion with dissimilar metal fixation. When reviewed as raw values, there was a difference in mean chromium levels between ADM and MDM cohorts (ADM=1.4 (+/− 2.5) vs MDM=1.2 (+/− 1.7), p=0.03; no other significant differences were found. An additional 32 ADM have been evaluated recently without elevation in cobalt or chromium levels. Of the total 55 ADM patients 4 had a 1mm polar gaps which filled in at 6–23 months postoperative. There were no polar gaps in the MDM series and one malseated liner. Conclusion. There were no significant differences in metal ion elevation minimum one year post implantation between primary ADM and revision MDM cohorts. This is encouraging based on the titanium/cobalt chrome interface in the MDM implant. Uncommon dome gaps in the monoblock ADM is not a clinical problem. For any tables or figures, please contact the authors directly

Introduction. Acromial and scapular fractures are a rare but difficult complication with reverse total shoulder arthroplasty (rTSA), with an incidence rate reported from 1–10%. The risk factors associated with these fractures types is largely unknown. The goal of this study is to analyze the clinical outcomes, demographic and comorbidity data, and implant sizing and surgical technique information from 4125 patients who received a primary rTSA with one specific prosthesis (Equinoxe, Exactech, Inc) and were sorted based on the radiographic documentation of an acromial and/or scapula fracture (ASF) to identify factors associated with this complication. Methods. 4125 patients (2652F/1441M/32 unspecified; mean age: 72.5yrs) were treated with primary rTSA by 23 orthopaedic surgeons. Revision and fracture reverse arthroplasty cases were excluded. The radiographic presence of each fracture was documented and classified using the Levy classification method. 61 patients were identified as having ASF, 10 patients had fractures of the Type 1, 32 patients had Type 2, and 18 patients had Type 3 fractures according to Levy's classification. One fracture was not classifiable. Pre-op and post-op outcome scoring, ROM as well as demographic, comorbidity, implant, and surgical technique information were evaluated for these 61 patients and compared to the larger cohort of patients to identify any associations. A two-tailed, unpaired t-test identified differences (p<0.05). Results. The overall rate of ASF was 1.48% with the average time after surgery occurring at 12.9 ± 17.9 months (range 1 day to 78 months). Men had an ASF rate of 0.69% (10 of 1441); whereas women had a rate of 1.92% (51 of 2652). Patients with ASF were observed to be significantly shorter than patients without ASF (65.1 in vs 63.3 in, p=0.0004). ASF were more common in females (p=0.0019), have Rheumatoid Arthritis (p=0.0051), Cuff Tear Arthropathy (p=0.0093), or previous shoulder surgery (p=0.0189). Patient's weight did not correlate, nor did BMI. No difference was observed in humeral stem size, glenosphere diameter, or the humeral tray offset, humeral liner offset, or combined humeral tray+liner offset. The average number of screws used in the fracture group was significantly more than in the non-fracture group (p=0.0327), and 93% of patients in the fracture group had a screw in the superior hole of the baseplate. Pre-operatively, patients who developed ASF had significantly worse ASES (p=0.0104) and SPADI (p=0.0136) scores and also had significantly worse forward elevation (p=0.0237) and internal rotation (p=0.0054) than those who did not develop ASF. At latest follow-up, patients with ASF had significantly worse SST, UCLA, ASES, Constant, and SPADI scores (all p<0.0001); significantly worse abduction, forward elevation, internal rotation, strength (all p<0.0001); and significantly less preop-to-postop improvement in all measured outcomes, except for external rotation (all p<0.0001). Finally, 24% of fractures were identified as being caused by a traumatic event, 28% of patients with fractures had a previous acromioplasty, and 53% of fractures were Levy type 2. Discussion. Acromial and scapular fractures after rTSA are a rare complication, with an incidence of 1.48% in this analysis of 4125 patients with a single rTSA prosthesis. These fractures were observed to occur at an average of 12.9 months after surgery, but were observed as early as 1 day and as late as 6.5 years. Female patients, Rheumatoid Arthritis, Cuff Tear Arthropathy, previous shoulder surgery, relatively worse pre-operative ASES or SPADI scores, relatively decreased pre-operative forward elevation and internal rotation as well as a larger number of screws placed in the baseplate all were significantly associated with the occurrence of ASF. Although 93% of patients with ASF had a screw placed in the superior hole of the baseplate, we cannot conclude that this is a driving factor at this time, as the superior screw number for the non-fracture group was not recorded. Future work should evaluate if usage of a superior glenoid baseplate screw and previous acromioplasty are also risk factors for these fracture types after rTSA. This study is the largest ever performed analysis of this rare complication and provides news insight into the predisposing risk factors to consider when evaluating patients for rTSA

Background. Joint line, patellar height and posterior condylar offset (PCO) are related to functional outcome such as stability and range of motion after revision total knee arthroplasty (TKA). The purpose of this study was (1) to determine whether revision TKA can restore the joint line, patella height and condylar offset after surgery, and (2) to assess factors associated with failed restoration. Materials and Methods. We retrospectively reviewed 27 consecutive patients who underwent revision TKA. Among 27 patients, 11 patients had two-stage revision TKA due to periprosthetic joint infection while 14 patients underwent revision TKA due to aseptic loosening. In addition, there were 2 patients who had traumatic event causing a periprosthetic fracture which led to revision TKA. The joint line was measured using the distance from the adductor tubercle of the femur to the most distal portion of the medial femoral component on knee anterior-posterior radiographs. Patella height was assessed using the Caton-Deschamps method. In addition, PCO were measured relative to the tangent of the posterior cortex of the femur using knee lateral radiograph. All parameters were compared between pre- and postoperative radiographs after revision TKA. Results. After revision TKA, mean joint line elevation was 0.9 mm. Seven of 27 patients showed joint line elevation of 5 mm or more. There was no significant difference between pre- and postoperative PCO (27.6 mm and 28.1 mm, respectively; P = 0.528). Fifteen patients (56%) showed patellar baja after revision TKA. Compared to the patients with aseptic loosening, the patients with periprosthetic joint infection or fracture showed greater joint line elevation (4.1 mm and −2.2 mm, respectively; P < 0.01), smaller PCO change (1.9 mm and −1.1 mm respectively, P < 0.05). Even if the cause of revision TKA was not associated with the postoperative patellar baja, presence of preoperative patellar baja was significantly associated with postoperative patellar baja (P < 0.05). Conclusions. Overall, restoration of the joint line and PCO were achieved in contemporary revision TKA. However, the patients who underwent revision TKA due to periprosthetic joint infection or fracture showed greater joint line elevation as well as smaller PCO. In addition, the patellar height was not improved in patients with preoperative patellar baja. Further evaluation of functional outcome is needed to assess correlation between radiological and functional outcome

Objectives. We have encountered patients who developed large joint fluid collections with massive elevations in chromium (Cr) and cobalt (Co) concentrations following metal-on-metal (MoM) hip arthroplasties. In some cases, retrieval analysis determined that these ion concentrations could not be explained simply by the wear rates of the components. We hypothesized that these effects may be associated with aseptic lymphocyte-dominated vasculitis-associated lesion (ALVAL). Patients and Methods. We examined the influence of the ALVAL grade on synovial fluid Co and Cr concentrations following adjustment for patient and device variables, including volumetric wear rates. Initially restricting the analysis to include only patients with one MoM hip resurfacing device, we performed multiple regression analyses of prospectively collected data. We then repeated the same statistical approach using results from a larger cohort with different MoM designs, including total hip arthroplasties. Results. In the resurfacing cohort (n = 76), the statistical modelling indicated that the presence of severe ALVAL and a large fluid collection were associated with greater joint fluid Co concentrations after adjustment for volumetric wear rates (p = 0.005). These findings were replicated in the mixed implant group (n = 178), where the presence of severe ALVAL and a large fluid collection were significantly associated with greater fluid Co concentrations (p < 0.001). Conclusion. The development of severe ALVAL is associated with elevations in metal ion concentrations far beyond those expected from the volumetric loss from the prosthetic surfaces. This finding may aid the understanding of the sequence of events leading to soft-tissue reactions following MoM hip arthroplasties. Cite this article: D. J. Langton, R. P. Sidaginamale, T. J. Joyce, J. G. Bowsher, J. P. Holland, D. Deehan, A. V. F. Nargol, S. Natu. Aseptic lymphocyte-dominated vasculitis-associated lesions are related to changes in metal ion handling in the joint capsules of metal-on-metal hip arthroplasties. Bone Joint Res 2018;7:388–396. DOI: 10.1302/2046-3758.76.BJR-2018-0037

Recent case reports have described V40 taper failure with clinically relevant adverse reaction to metal debris (ARMD). The real incidence of V40 taper damage and potential consequences are currently unclear, however. Aim of this study is therefore, to evaluate the long-term incidence of pseudotumors in a consecutive series of THA with V40 taper and identify potential influencing factors. From 2006 to 2007 a total number of 120 patients (127 hips) received either an uncemented (Accolade©) or cemented hip stem (ABGII©), both with V40 taper (Stryker© Mahwah, New Jersey, USA). They all were combined with 36 mm Vitallium (CoCrMo) heads and uncemented cups (Trident©) with XLPE inlays. 11,2 +/− 0,5 years post-op 82 patients with 87 hips (mean age 74 years, 58 % female) underwent clinical (PROMs) and radiographic evaluation. In 71 patients (75 hips) MARS- MRI of the hip was performed. 38 patients were lost to follow-up. In 81 patients (86 hips) chrome and cobalt levels were determined. MRI-investigation revealed 20 pseudotumors (26%) and 18 of them had a diameter of >2cm. Patients with pseudotumors had significant higher median cobalt ion levels compared to those without (2,85 μg/l vs. 1,32 μg/l; p=0,022) and a significant correlation between pseudotumors and cobalt levels was found. Radiographic osteolysis was associated with pseudotumors as well (p= 0,014). Neither approach, BMI, gender, age, type of stem, head length, inclination nor heterotope ossification showed a significant correlation to pseudotumor occurrence. Due to the high incidence of local ARMD in in asymptomatic patients with V40 taper and metal heads we recommend regular post-operative follow-up investigations including routine metal ion screening and consecutive MRI investigation upon elevation

Purpose. Total knee replacement is the one of the most performed surgeries. However, patient's satisfaction rate is around 70–90 % only. The sacrifice of cruciate ligament might be the main reason, especially in young and active patients. ACL stabilizes the knee by countering the anterior displacing and pivoting force, absorbs the shock and provides proprioception of the knee. However, CR knees has been plagued by injury of PCL during the surgery and preservation of the ACL is a demanding technique. Stiffness is more common comparing to PS designed knee. To insert a tibial baseplate with PE is usually thicker than 8 mm comparing to 2–4 mm of removed tibial bone. The stuffing of joint space may put undue tension on preserved ACL and PCL. Modern designed BCR has been pushed onto market with more sophisticated design and instrumentation. However, early results showed high early loosening rate. Failure to bring the tibia forward during cementing may be the main cause. The bone island where ACL footprint locates is frequently weak, intraoperative fracture happens frequently. A new design was developed by controlled elevation and reattachment of the ACL footprint to meet all the challenges. Method. A new tibial baseplate with a keel was designed. The central part of the baseplate accommodates elevated bony island with ACL footprint. The fenestrations at the central part is designed for reattachment of bony island under proper tension with heavy sutures and fixed at anterior edge of the baseplate in suture bridge fashion and also for autograft to promote bony healing after reattachment. The suture bridge method has been used by arthroscopists for ACL avulsion fracture without the need of immobilization. The elevation of bony island release the tension in the ACL which come from stuffing of baseplate and PE insert and greatly facilitate cementing of the baseplate. The keel improve the weakness of traditional U shape design of BCR knees. Instead of keeping the bony island intact by separately cutting the medial and lateral tibial plateau in BCR knees in the past, we choose to saw the tibial plateau in one stroke as in PS knees, then removes the two condyles. The bony island includes the footprint both ACL and PCL. The central part of tibial baseplate will push the bony island upward which release the undue tension in the cruciate ligaments. Summary. We proposed a new solution for the kinematic conflict in the present bi-cruciate knee designs by elevation and re- attachment of bony island with ACL footprint at the same time simplify the ACL preservation. The simple tibial cutting procedure also facilitate the process. The technique protects PCL from injury during tibial bone cutting in CR knees. We believe the new BCR design has the potential to replace CR knee in term of function and longevity in the future

The function of the shoulder joint has traditionally been evaluated based on range of motion (ROM) in predefined anatomical planes and also by using functional scores, which assessed shoulder function based on the ability to conduct certain activities of daily living (ADLs). However, measuring ROM only in terms of flexion-extension, abduction-adduction and internal-external rotation may under-account for the 3-dimensional mobility of the shoulder joint. Furthermore, functional scores, such as the Oxford shoulder score or American shoulder and elbow surgeons (ASES) score, are subjective measures and are not an accurate assessment of shoulder joint function. In this study, we proposed the use of the globe model of the shoulder joint which can be used to provide an objective measure of the global ROM and also function of the shoulder joint – termed the Global and Functional arc of motion (GAM and FAM). Thirty-three young, healthy male patients (23.7 ± 1.5 years) were recruited and tasked to perform eight ADLs and a full humeral circumduction movement which represented their active global ROM. Reflective markers were placed in accordance to the International Society of Biomechanics (ISB) and optical-based motion capture cameras were used to track relative motion of the dominant humerus with respect to the thorax (i.e. thoracohumeral motion). The GAM and FAM were generated by plotting the thoracohumeral on a spherical coordinate system during global ROM and the eight ADLs respectively. Shoulder joint global ROM and function were quantified by calculating the area enclosed by the closed loop of GAM and FAM respectively. The spherical coordinate system, or more commonly referred to as the globe model, describes thoracohumeral movement using plane of elevation (POE), angle of elevation (AOE) and rotation. In our model, POE and AOE represents longitude and latitude of the globe respectively, and rotation is depicted using a red-green-blue (RGB) colour scale. Overall, subject's GAM of the shoulder joint covered an area of 4.64 ± 0.48 units2 compared to only 1.12 ± 0.26 units2 for the FAM. Subjects only required 24.4 ± 5.7 % of their global shoulder ROM for basic daily functioning. Studies that reduced shoulder joint movement into planar movements (i.e. sagittal, coronal and rotation) do not account for the 3-dimensional nature of the joint and doing so may overestimate the requirement of the shoulder joint for ADLs relative to its ROM in each plane. While others have attempted to use the globe model, such studies tend to reduce the globe into its descriptive angles (i.e. POE, AOE and rotation), reducing its intuitiveness. In contrast, by keeping an intact globe, the proposed globe model was more intuitive and yet capable of quantifying both shoulder joint global ROM and function. Doing so, we found that young healthy subjects only required approximately a quarter of their global ROM of the shoulder joint to complete the most common daily tasks, which was significantly less than what was previously reported

Introduction:. Reverse shoulder arthroplasty (RSA) has proven to be a useful tool to manage a variety of pathologic conditions. However, inconsistent improvement in motion occurs in patients who have undergone RSA for revision shoulder arthroplasty, proximal humeral fracture sequelae, and treatment of infection. Additional factors that have been suggested to produce poor postoperative range of motion (ROM) may be associated with patient's factors such as poor preoperative range of motion and surgical factors such as inability to lengthen the arm. The purpose of this study was to analyze multiple factors which may be responsible in predicting motion after RSA. It is our hypothesis that intraoperative ROM is most predictive of postoperative ROM. Methods:. Between February 2003 and April 2011 566 patients (225 male and 341 female) treated with a RSA for 1) acute proximal humeral fracture (11), 2) Sequeala of proximal humeral fractures (31), 3) cuff tear arthropathy (278), 4) massive cuff tear without arthritis (78), 5) failed shoulder arthroplasty (168) and 6) infection (29) were evaluated with preoperative range of motion, intraoperative range of motion and range of motion at a minimum of 2-year postoperative follow up. A single observer recorded intraoperative flexion (IFF) in 30° increments. Preoperative and postoperative ROM was recorded by patient video or a previously validated patient performed outcome measure. Preoperative diagnosis was confirmed by radiographic and intraoperative information. 477 patients had preoperative and postoperative radiographs available for analysis of acromial-greater tuberosity distance change (AGT) which was utilized to calculate arm lengthening. A regression analysis was then performed to determine which factors were most influential in predicting postoperative active range of motion. Results:. IFF was the strongest predictor of final postoperative ROM, followed by gender and preoperative ROM. Age, AGT and treatment for the purposes of revision, infection or massive cuff tear were not significant independent predictors of postoperative ROM. Compared to patients with intraoperative forward elevation of ≤60 degrees, patients with intraoperative elevation of 90 degrees gained 16° in postoperative forward elevation (p = 0.029), patients with intraoperative elevation of 120 degrees gained roughly 38° in postoperative forward elevation (p < 0.001) and patients with intraoperative elevation of 150 degrees gained roughly 49 degrees in postoperative forward elevation (p < 0.001). Patients with 120° or more intraoperative elevation were nine times more likely (OR = 9.04, 95%CI: 4.96–16.47) than patients with 90° or less intraoperative elevation to have postoperative forward elevation of 150° or more (top 25% of postoperative results). Conclusions:. Intraoperative forward flexion is strongest predictor postoperative ROM. Surgeons are able to use intraoperative motion as a powerful tool in decision making regarding soft tissue tension in reverse shoulder arthroplasty, therefore by maximizing intraoperative motion, patients have a much greater likelihood of improvement in their final active motion

Introduction and Objective. Current cartilage repair strategies lack adequate tissue integration capacity and often present mechanical failure at the graft-to-host tissue junction. The design of multilayered osteochondral tissue engineering (TE) constructs is an attractive approach to overcome these problems. However, calcium ion-release from resorbable bone-replacement materials was suggested to compromise chondrogenic differentiation of adjacent cartilage tissue and it is unclear whether articular chondrocytes (AC) or mesenchymal stroma cells (MSC) are more sensitive to such conditions. Aim of the study was to compare how elevated calcium levels affect cartilage matrix production during re-differentiation of AC versus chondrogenic differentiation of MSC. The results of this study will help to identify the ideal cell source for growth of neocartilage adjacent to a calcified bone replacement material for design of multilayered osteochondral TE approaches. Materials and Methods. Expanded human AC and MSC (6–12 donors per group) were seeded in collagen type I/III scaffolds and cultured under standard chondrogenic conditions at control (1.8mM) or elevated (8.0mM) CaCl2 for 35 days. Proteoglycan and collagen production were assessed via radiolabel-incorporation, ELISA, qPCR and Western blotting. Differences between groups or cell types were calculated using the non-parametric Wilcoxon or Mann-Whitney U test, respectively, with p < 0.05 considered significant. Results. Elevated calcium significantly reduced GAG synthesis (63% of control, p=0.04) and chondrogenic marker expression of AC, lowering the GAG/DNA content (47% of control, p=0.004) and collagen type II deposition (24% of control, p=0.05) of neocartilage compared to control conditions. Opposite, at elevated calcium levels MSC-derived chondrocytes significantly increased GAG synthesis (130% of control, p=0.02) and collagen type II content (160% of control, p=0.03) of cartilage compared to control tissue. Chondrogenic and hypertrophic marker expression was insensitive to calcium levels in MSC-derived chondrocytes. As a result, maturation under elevated calcium allowed for a significantly higher GAG/DNA content in MSC-derived samples compared to AC constructs, although under control conditions both groups developed similarly. Conclusions. AC and MSC showed an opposite reaction to elevation of calcium levels regarding cartilage matrix production and we propose MSC as a preferred cell source to grow chondrocytes in vicinity to calcified bone replacement materials. Since MSC remained prone to hypertrophy under elevated calcium, trizonal cartilage TE constructs, where an AC-layer is separated from the bone replacement phase by an intermediate layer of MSC appear as an ideal design for multilayered osteochondral TE with respect to calcium sensitivity of cells and protection of the upper cartilage layer from hypertrophy

Purpose of the study: Reversed prostheses provide improved active anterior elevation in shoulders free of cuff tears by lengthening the deltoid and increasing is lever arm. The purpose of this work was to search for a correlation between arm lengthening and postoperative active anterior elevation. Material and methods: One hundred eighty-three reversed prostheses were reviewed with minimum one year follow-up for a complete clinical and radiographic work-up. Using a previously validated protocol, arm lengthening was assessed either in comparison with the contralateral side or with preoperative measurements. A statistical analysis was performed to search for a correlation between lengthening of the humerus and the arm with active anterior elevation. Results: Considering the entire series, mean lengthening of the humerus was 0.2±1.4 cm (range −4.7 to +5.4). Postoperative active anterior elevation was 141±27 (range 30–180). There was no correlation between humerus lengthening or shortening and active anterior elevation (p=0.169). A shorter arm produced an active anterior elevation at 121 and 0 – 1 cm lengthening an active anterior elevation at 140; lengthening 1 – 2.5 cm gave active anterior elevation at 144 and beyond 2.5 cm 147. The difference in active anterior elevation was statistically significant (p< 0.001) between patients with a shortening and those with a lengthening. Discussion: Arm lengthening corresponds to a lengthening of the humerus plus a lengthening of the infra-acromial space. We found a statistically negative correlation between arm shortening (and thus deltoid shortening) and active anterior elevation and a positive trend between lengthening and active anterior elevation. Our measurement did not take into account the increased lever arm of the deltoid and thus only partially expresses the improvement in deltoid function. Nevertheless, our study shows that objective evaluation of deltoid lengthening is possible pre- intra- and postoperatively and that this measurement can be correlated with postoperative functional outcome

Introduction and Objective. Several in vitro studies have shed light on the osteogenic and chondrogenic potential of graphene and its derivatives. Now it is possible to combine the different biomaterial properties of graphene and 3D printing scaffolds produced by tissue engineering for cartilage repair. Owing to the limited repair capacity of articular cartilage and bone, it is essential to develop tissue-engineered scaffolds for patients suffering from joint disease and trauma. However, chondral lesions cannot be considered independently of the underlying bone tissue. Both the microcirculation and the mechanical support provided with bone tissue must be repaired. One of the distinctive features that distinguish graphene from other nanomaterials is that it can have an inductive effect on both bone and cartilage tissue. In this study, the effect of different concentrations of graphene on the in vivo performance of single-layer poly-ε-caprolactone based-scaffolds is examined. Our hypothesis is that graphene nanoplatelet- containing, robocast PCL scaffolds can be an effective treatment option for large osteochondral defect treatment. For this purpose, different proportions of graphene- containing (1%,3%,5%,10 wt%) PCL scaffolds were studied in a 5mm diameter osteochondral defect model created in the rabbit knee. Materials and Methods. In the study graphene-containing (1, 3, 5, 10 wt%), porous and oriented poly-ε-caprolactone-based scaffolds were prepared by robocasting method to use in the regeneration of large osteochondral defects. Methods: The scaffolds were implanted into the full-thickness osteochondral defect in a rabbit model to evaluate the regeneration of defect in vivo. For this purpose, twenty female New Zealand white rabbits were used and they were euthanized at 4 and 8 weeks of implantation. The reparative osteochondral tissues were harvested from rabbit distal femurs and then processed for gross appearance assessment, radiographic imaging, histopathological and immunohistochemical examinations. Results. Results revealed that, graphene- containing graft materials caused significant amelioration at the defect areas. Graphene-containing graft materials improved the fibrous, chondroid and osseous tissue regeneration compared to the control group. The expressions of bone morphogenetic protein-2 (BMP-2), collagen-1 (col-1), vascular endothelial growth factor (VEGF) and alkaline phosphatase (ALP) expressions were more prominent in graphene- containing PCL implanted groups. Results also revealed that the ameliorative effect of graphene increased by the elevation in concentration. The most prominent healing was observed in 10 wt% graphene-containing PCL based composite scaffold implanted group. Conclusions. This study demonstrated that graphene- containing, robocast PCL scaffolds has efficacy in the treatment of large osteochondral defect. Subchondral new bone formation and chondrogenesis were observed based on immunohistochemical examinations. 3D printed PCL platforms have great potential for the investigation of the osteochondral regeneration mechanism. The efficacy of graphene-containing PCL scaffolds on osteogenesis, vascularization, and mineralization was shown at different graphene concentrations at 4th and 8th weeks. Immunohistochemical studies showed statistical significance in the 5wt% and 10 wt% graphene-containing groups compared to the 1wt% and 3 wt% graphene-containing groups at the end of the eighth week

We reviewed the outcome of 28 patients who had been treated using the Aequalis fracture prosthesis for an acute fracture of the proximal humerus at a mean follow-up of 39.3 months (24 to 63). The mean age of the patients at the time of the fracture was 66.3 years (38 to 80). The mean Constant score was 68.2 (37 to 84) for the operated shoulder, which represented 89.5% of the mean score for the uninjured side (p < 0.001). The quality of the reconstruction as shown on the immediate post-operative radiographs was categorised into three types, anatomical, acceptable, and unacceptable, depending on the position of the tuberosities relative to the prosthetic head and the humeral shaft. Anatomical reconstruction was associated with a higher mean Constant score as well as higher mean values of anterior forward elevation, abduction and external rotation than the other types, but the differences were not statistically significant (p > 0.231). A total of 18 patients had active anterior elevation ≥150°. Their mean active abduction and external rotation were 163.6° and 31.3°, respectively. In seven of the 28 patients, the mean active anterior elevation, abduction and external rotation were 130.7°, 129.2° and 22.8°, respectively. In all, 12 patients were very satisfied with the results, 12 were satisfied, two were dissatisfied and two were disappointed; 26 reported no or only mild pain while only two had moderate pain. In five patients proximal migration of the humeral head was shown on the anteroposterior radiographs of the shoulder. No evidence of loosening was found in any prosthesis

Aims. The aim of this study was to report the outcomes of different treatment options for glenoid loosening following reverse shoulder arthroplasty (RSA) at a minimum follow-up of two years. Patients and Methods. We retrospectively studied the records of 79 patients (19 men, 60 women; 84 shoulders) aged 70.4 years (21 to 87) treated for aseptic loosening of the glenosphere following RSA. Clinical evaluation included pre- and post-treatment active anterior elevation (AAE), external rotation, and Constant score. Results. From the original cohort, 29 shoulders (35%) were treated conservatively, 27 shoulders (32%) were revised by revision of the glenosphere, and 28 shoulders (33%) were converted to hemiarthroplasty. At last follow-up, conservative treatment and glenoid revision significantly improved AAE, total Constant score, and pain, while hemiarthroplasty did not improve range of movement or clinical scores. Multivariable analysis confirmed that conservative treatment and glenoid revision achieved similar improvements in pain (glenoid revision vs conservative, beta 0.44; p = 0.834) but that outcomes were significantly worse following hemiarthroplasty (beta -5.00; p = 0.029). Conclusion. When possible, glenoid loosening after RSA should first be treated conservatively, then by glenosphere revision if necessary, and last by salvage hemiarthroplasty. Cite this article: Bone Joint J 2019;101-B:461–469

Introduction. Achieving proper ligament tension in knee flexion within cruciate retaining (CR) total knee arthroplasty (TKA) has long been associated with clinical success. The distal femoral joint line (DFJL) is routinely used as a variable to assist in achieving proper flexion-extension gap balancing. No prior study has observed the possible effects of properly restoring the DFJL may have on ligament tension in flexion. The purpose of this computational analysis was to determine what effect the DFJL may have on ligament strains and tibiofemoral kinematics of CR knee designs in flexion. Methods. A computational analysis was performed utilizing a musculoskeletal modeling system with ligaments modeled as non-linear elastic. Tibiofemoral kinematics, contact points estimated from the femoral condyle low points, and ligament strain, change in length relative to the unloaded length, were measured at 90° knee flexion during a deep knee bend activity. Two different knee implants, a High Flexion CR (HFCR) and a Guided Motion CR (GMCR) design were used. Simulations were completed for changes in superior-inferior (SI) positioning of the femoral implant relative to the femur bone, in 2mm increments to simulate over and under resection of the DFJL. Results. The medial condyle of the femoral implant was 0.67mm and 0.47mm more posterior relative to the tibia per 1mm elevation of the DFJL for the HFCR and GMCR designs respectively. The lateral condyle was 0.80mm and 1.06mm more posterior relative to the tibia per 1mm elevation of the DFJL for the HFCR and GMCR designs, respectively. The strain in the LCL and MCL changed less than 0.0005mm/mm per 1mm change in DFJL indicating that those structures were not affected. The PCL bundles and the ITB were affected by changes in DFJL with strain increasing 0.005 and 0.004mm/mm in the AL PCL bundle respectively for HFCR and GMCR, strain increasing 0.006mm/mm in the PM PCL for both HFCR and GMCR, and ITB strain decreasing 0.006 and 0.004mm/mm respectively for the HFCR and GMCR per 1mm elevation of the DFJL. Discussion. Our findings suggest that DFJL affects ligament tension at 90° knee flexion and therefore flexion balance for cruciate retaining implants. The effect on ligament tension results from changes in the position of the femur bone and its ligament attachments with respect to the tibia, which is dependent on the implant geometry. DFJL places greater strain on the PCL because the conformity of the medial condyle prevents the femoral implant from sitting more posterior by the full amount of the DFJL elevation, which would be necessary to maintain the same AP position of the of the femur bone relative to the tibia and avoid increasing PCL strain. These results indicate that elevating the DFJL to address a tight extension space in a CR knee while the flexion space is well balanced could result in increased flexion tension especially when the flexion-extension mismatch is large, so to achieve balanced flexion and extension the amount of DFJL elevation may need to be reduced and the tibial resection may also need to be increased

Aims. The aim of this study was to evaluate the clinical and radiological outcomes of locking plate fixation, with and without an associated fibular strut allograft, for the treatment of displaced proximal humeral fractures in elderly osteoporotic patients. Patients and Methods. We undertook a retrospective comparison of two methods of fixation, using a locking plate without an associated fibular strut allograft (LP group) and with a fibular allograft (FA group) for the treatment of these fractures. The outcome was assessed for 52 patients in the LP group and 45 in the FA group, with a mean age of 74.3 years (52 to 89), at a mean follow-up of 14.2 months (12 to 19). The clinical results were evaluated using a visual analogue scale (VAS) score for pain, the Constant score, the American Shoulder and Elbow Surgeons (ASES) score, and the range of movement. Radiological results were evaluated using the neck-shaft angle (NSA) and humeral head height (HHH). Results. The mean forward elevation in the LP and FA groups was 125.3° (. sd. 21.4) and 148.9° (. sd. 19.8), respectively (p = 0.042), while other clinical factors showed no statistically significant differences between the groups. The changes in NSA and HHH immediately after the operation and at final follow-up were significantly better in the FA group than in the LP group (p = 0.015 and p = 0.021, respectively). Conclusion. For comminuted proximal humeral fractures in osteoporotic patients, locking plate fixation with a fibular strut allograft shows satisfactory short-term results with respect to humeral head support and maintenance of reduction, and may reduce the incidence of complications associated with fixation using a locking plate alone. Cite this article: Bone Joint J 2019;101-B:260–265

Purpose of the study: Little is known about the clinical profile of patients aged less than 65 years who present a large or massive rotator cuff tear. We hypothesized that this clinical profile depends on the type of tear. Material and method: This was a prospective descriptive multicentric study over a period of six months which included 112 patients aged less than 65 years, 66 men and 46 women, mean age 56.3 years (range 35–65) who had a large or massive rotator cuff tear. The Constant score and active and passive range of motion, subacromial height and fatty infiltration according to the Goutallier classification were noted. Patients were divided into four classes according to deficit in active elevation and external rotation: class A (n=55, no deficit), class B (n=19, deficient elevation alone), class C (n=28, deficient external rotation alone), class C (n=10, deficient elevation and external rotation). Results: These classes were not significantly different for age, sex-ratio, duration of symptoms, or presence of subscapular involvement. Trauma was involved more often in patients in class B and class D. The mean absolute Constant score was significantly lower in patients in class B (30.2) or D (23.5) than in class A (53.3) or C (44.7). The subacromial space was significantly narrower in group D (5 mm) than in the other groups. Fatty infiltration of the infraspinatus scores > II was significantly more common in groups C and D. Severe fatty degeneration of the subscapular (> II) was found in only eight shoulders and was not correlated with defective active elevation. Discussion: This study demonstrates that deficient external rotation is correlated with the type of tear but has little impact on the Constant score. Conversely, patients with deficient active elevation have a lower Constant score but do not exhibit characteristically different tears than patients without deficient active elevation. Thus, the management scheme should be no different in patients with deficient elevation than in patients with out deficient elevation, excepting cases with a major lesion of the subscapularis

Reverse total shoulder replacement (RTSR) depends on adequate deltoid function for a successful outcome. However, the anterior deltoid and/or axillary nerve may be damaged due to prior procedures or injury. The purpose of this study was to determine the compensatory muscle forces required for scapular plane elevation following RTSR when the anterior deltoid is deficient. The soft tissues were removed from six cadaver shoulders, except for tendon attachments. After implantation of the RTSR, the shoulders were mounted on a custom-made shoulder simulator to determine the mean force in each muscle required to achieve 30° and 60° of scapular plane elevation. Two conditions were tested: 1) Control with an absent supraspinatus and infraspinatus; and 2) Control with anterior deltoid deficiency. Anterior deltoid deficiency resulted in a mean increase of 195% in subscapularis force at 30° when compared with the control (p = 0.02). At 60°, the subscapularis force increased a mean of 82% (p < 0.001) and the middle deltoid force increased a mean of 26% (p = 0.04). Scapular plane elevation may still be possible following an RTSR in the setting of anterior deltoid deficiency. When the anterior deltoid is deficient, there is a compensatory increase in the force required by the subscapularis and middle deltoid. Attempts to preserve the subscapularis, if present, might maximise post-operative function

Some surgeons are reluctant to perform a reverse total shoulder arthroplasty (RTSA) on both shoulders because of concerns regarding difficulty with activities of daily living post-operatively as a result of limited rotation of the shoulders. Nevertheless, we hypothesised that outcomes and patient satisfaction following bilateral RTSA would be comparable to those following unilateral RTSA. A single-surgeon RTSA registry was reviewed for patients who underwent bilateral staged RTSA with a minimum follow-up of two years. A unilateral RTSA matched control was selected for each shoulder in those patients undergoing bilateral procedures. The Constant–Murley score (CMS), American Shoulder and Elbow Surgeons (ASES) score, Subjective Shoulder Values (SSV), visual analogue scale (VAS) for pain, range of movement and strength were measured pre- and post-operatively. The mean CMS, ASES, SSV, VAS scores, strength and active forward elevation were significantly improved (all p < 0.01) following each operation in those undergoing bilateral procedures. The mean active external rotation (p = 0.63 and p = 0.19) and internal rotation (p = 0.77 and p = 0.24) were not significantly improved. The improvement in the mean ASES score after the first RTSA was greater than the improvement in its control group (p = 0.0039). The improvement in the mean CMS, ASES scores and active forward elevation was significantly less after the second RTSA than in its control group (p = 0.0244, p = 0.0183, and p = 0.0280, respectively). Pain relief and function significantly improved after each RTSA in those undergoing a bilateral procedure. Bilateral RTSA is thus a reasonable form of treatment for patients with severe bilateral rotator cuff deficiency, although inferior results may be seen after the second procedure compared with the first. Cite this article: Bone Joint J 2013;95-B:1232–8

Introduction. Being challenging, multifragmentary proximal tibial fractures in patients with severe soft tissue injuries and/or short stature can be treated using externalized locked plating. A recent finite element study, investigating the fixation stability of plated unstable tibial fractures with 2-mm, 22-mm and 32-mm plate elevation under partial and full weight-bearing, reported that from a virtual biomechanical point of view, externalized plating seems to provide appropriate relative stability for secondary bone healing under partial weight-bearing during the early postoperative phase. The aim of the current study was to evaluate the clinical outcomes of using a LISS plate as a definitive external fixator for the treatment of multifragmentary proximal tibial fractures. Methods. Following appropriate indirect reduction, externalized locked plating was performed and followed up in 12 patients with multifragmentary proximal tibial fractures with simple intraarticular involvement and injured soft tissue envelope. Results. Among all patients, the average follow up period was 22 months (range14–48 months), revealing uneventful healing in all of them. Time to fracture union was 21.8 weeks on average (range 16–28weeks). The mean HSS knee score was 87 (range 72–98) at 4 weeks postoperatively and 97 (range 88–100) at the final follow up. The average AOFAS score was 92 (range 84–100) at 4 weeks postoperatively and 98 (range 94–100) at the final follow up. Conclusions. Externalized locked plating seems to be a successful surgical alternative treatment in selected cases with unstable proximal tibial fractures and severe soft tissue injury, following appropriate indirect fracture reduction

Aims. We performed a systematic review of the literature to determine whether earlier surgical repair of acute rotator cuff tear (ARCT) leads to superior post-operative clinical outcomes. Methods. The MEDLINE, Embase, CINAHL, Web of Science, Cochrane Libraries, controlled-trials.com and clinicaltrials.gov databases were searched using the terms: ‘rotator cuff’, or ‘supraspinatus’, or ‘infraspinatus’, or ‘teres minor’, or ‘subscapularis’ AND ‘surgery’ or ‘repair’. This gave a total of 15 833 articles. After deletion of duplicates and the review of abstracts and full texts by two independent assessors, 15 studies reporting time to surgery for ARCT repair were included. Studies were grouped based on time to surgery < 3 months (group A, seven studies), or > 3 months (group B, eight studies). Weighted means were calculated and compared using Student’s t-test. . Results. Group B had a significantly higher pre-operative Constant score (CS) (p < 0.001), range of movement in external rotation (p = 0.003) and abduction (p < 0.001) compared with group A. Both groups showed clinical improvement with surgical repair; group A had a significantly improved Constant score, University of California, Los Angeles (UCLA) shoulder score, abduction and elevation post-operatively (all p < 0.001). Group B had significantly improved Constant score (p < 0.001) and external rotation (p < 0.001) post-operatively. The mean Constant score improved by 33.5 for group A and by 27.5 for group B. Conclusion. These findings should be interpreted with caution due to limitations and bias inherent to case-series. We suggest a trend that earlier time to surgery may be linked to better Constant score, and active range of movement in abduction and elevation. Additional prospective studies are required

After establishing anatomical feasibility, functional reconstruction to replace the anterolateral part of the deltoid was performed in 20 consecutive patients with irreversible deltoid paralysis using the sternoclavicular portion of the pectoralis major muscle. The indication for reconstruction was deltoid deficiency combined with massive rotator cuff tear in 11 patients, brachial plexus palsy in seven, and an isolated axillary nerve lesion in two. All patients were followed clinically and radiologically for a mean of 70 months (24 to 125). The mean gender-adjusted Constant score increased from 28% (15% to 54%) to 51% (19% to 83%). Forward elevation improved by a mean of 37°, abduction by 30° and external rotation by 9°. The pectoralis inverse plasty may be used as a salvage procedure in irreversible deltoid deficiency, providing subjectively satisfying results. Active forward elevation and abduction can be significantly improved

Aims. We report the clinical results of glenoid osteotomy in patients with atraumatic posteroinferior instability associated with glenoid dysplasia. Patients and Methods. The study reports results in 211 patients (249 shoulders) with atraumatic posteroinferior instability. The patients comprised 63 men and 148 women with a mean age of 20 years. The posteroinferior glenoid surface was elevated by osteotomy at the scapular neck. A body spica was applied to maintain the arm perpendicular to the glenoid for two weeks postoperatively. Clinical results were evaluated using the Rowe score and Japan Shoulder Society Shoulder Instability Score (JSS-SIS); bone union, osteoarthrosis, and articular congruity were examined on plain radiographs. Results. The Rowe score improved from 36 to 88 points, and the JSS-SIS improved from 47 to 81 points. All shoulders exhibited union without progression of osteoarthritis except one shoulder, which showed osteoarthritic change due to a previous surgery before the glenoid osteotomy. All but three shoulders showed improvement in joint congruency. Eight patients developed disordered scapulohumeral rhythm during arm elevation, and 12 patients required additional open stabilization for anterior instability. Conclusion. Good results can be expected from glenoid osteotomy in patients with atraumatic posteroinferior instability associated with glenoid dysplasia. Cite this article: Bone Joint J 2018;100-B:331–7

Introduction. Mechanical or corrosive failure of total knee arthroplasties (TKAs) is difficult to diagnose with current laboratory and radiographic analyses. As such, the goal of this study was to determine the mean blood concentration of cobalt, chromium, and titanium in a series of revision TKAs with mechanical implant failure and evaluate whether they facilitated identification of the underlying TKA failure mechanism. Methods. Serum cobalt, chromium, and titanium levels and synovial fluid characteristics were evaluated in 12 patients (13 aseptic revision TKAs) who underwent revision TKA between 2000 and 2020 at a single academic institution for mechanical implant failure or corrosion. Seventy-five percent were re-revisions of previously revised TKAs. Mean time to revision was 6 years. Modular metallic junctions were present in 100%. Twenty-five percent did not have another in situ total joint arthroplasty, and the remaining patients did not have a metal-on-metal articulation that could lead to elevation in serum metal ion levels. Mean follow-up after the revision TKA was 8 months. Results. Mean serum cobalt, chromium, and titanium concentrations were 11 ng/mL, 6 ng/mL, and 3 ng/mL, respectively. Serum metal ion levels facilitated failure mechanism identification in 75%, which included modular junction failure (6 cases), constraint locking mechanism failure (3 cases), corrosion of modular metallic interfaces (2 cases), and implant fracture (1 case). Arthrocentesis was performed in 75%. Mean synovial fluid cell count was 950 cells/mcL. Monocytes were the predominant mean cell type (41%), followed by neutrophils (35%), and lymphocytes (22%). Conclusion. Serum metal ion assessment should be considered when the etiology of painful primary or revision TKAs, particularly those with modular metallic junctions, remains elusive after routine evaluation

Introduction. Surgeons commonly resect additional distal femur during primary total knee arthroplasty (TKA) to correct a flexion contracture. However, the effect of joint line proximalization on TKA kinematics is unclear. Thus, our goal was to quantify the effect of additional distal femoral resection on knee extension and mid-flexion laxity. Methods. Six computational knee models with TKA-specific capsular and collateral ligament properties were implanted with a contemporary posterior-stabilized TKA. A 10° flexion contracture was modeled to simulate a capsular contracture. Distal femoral resections of +2 mm and +4 mm were simulated for each model. The knees were then extended under standardized torque to quantify additional knee extension achieved. Subsequently, varus and valgus torques of ±10 Nm were applied as the knee was flexed from 0° to 90° at the baseline, +2 mm, and +4 mm distal resections. Coronal laxity, defined as the sum of varus and valgus angulation with respective torques, was measured at mid-flexion. Results. With +2 mm and +4 mm of distal femoral resection, the knee extended an additional 4°±0.5° and 8°±0.75°, respectively. At 30° and 45°of flexion, baseline laxity averaged 4.8° and 5.0°, respectively. At +2 mm resection, mean coronal laxity increased by 3.1° and 2.7° at 30° and 45°of flexion, respectively. At +4 mm resection, mean coronal laxity increased by 6.5° and 5.5° at 30° and 45° of flexion, respectively. Maximal increased coronal laxity for a +4 mm resection occurred at a mean 16° (range, 11–27°) of flexion with a mean increased laxity of 7.8° from baseline. Conclusion. While additional distal femoral resection in primary TKA increases knee extension, the consequent joint line elevation induces up to 8° of coronal laxity in mid-flexion in this computational model. As such, posterior capsular release prior to resecting additional distal femur to correct a flexion contracture should be considered

Reverse shoulder arthroplasty (RSA) is increasingly utilized to restore shoulder function in patients with osteoarthritis and rotator cuff deficiency. There is currently little known about shoulder function after RSA or if differences in surgical technique or implant design affect shoulder performance. The purpose of this study was to quantify scapulohumeral rhythm in patients with RSA during loaded and unloaded shoulder abduction. Eleven patients with RSA performed shoulder abduction (elevation and lowering) with and without a handheld 3kg weight during fluoroscopic imaging. Three RSA designs were included. We used model-image registration techniques to determine the 3D position and orientation of the implants. Cubic curves were fit to the humeral elevation as a function of the scapular elevation over the entire motion. The slope of this curve was used to determine the scapulohumeral rhythm (SHR). For abduction above 40°, shoulders with RSA exhibited an average SHR of 1.5:1. There was no significant difference in SHR between shoulder abduction with and without 3kg handheld weights (1.6±0.2 unweighted vs. 1.4±0.1 weighted), nor was there a significant difference between elevation and lowering. SHR was highly variable for abduction less than 40°, with SHR ranging from a low of 1 to greater than 10. For these very small groups, there was no apparent pattern of differences between implant designs having differing degrees of lateral offset. At arm elevation angles less than 40°, SHR in RSA shoulders is highly variable and the mean SHR (2–5) with RSA appears higher than SHR in normal shoulders (2–3). At higher elevation angles, SHR in shoulders with RSA (1.5–1.8) is much more consistent and appears lower than SHR in normal shoulders (2–4). With the small subject cohort, it was not possible to demonstrate differences between subjects with different implant designs. Ongoing analysis of reverse shoulder function with larger cohort sizes will allow us to refine our observations and determine if there are differences in shoulder function due to implant design, preoperative condition and rehabilitation protocols

Purpose: The purpose of this work was to study the biomechanical properties of mobile cup shoulder prostheses and factors affecting their kinetics. Material and methods: Bipolar shoulder prostheses were implanted in 39 patients with degenerative shoulders and a destroyed cuff. Radiocinematic recordings of anterior elevation and active rotation were made at a mean 32 months follow-up (13 months–550 months). Results: Three types of biomechanical behaviour were observed for elevation movements. “Normal” behaviour was observed in 17 prostheses with preservation of the scapulohumeral rhythm and chronological participation of the three articular interfaces [intraprosthetic (head/cup), extra-prosthetic (cup/glenoid), scapulothoracic]. Mean anterior elevation was 114.7° for these shoulders. A “paradoxical” behaviour was observed in ten prostheses. Anterior elevation depended entirely on the scapulorthoracic joint, and was limited on the average to 42.5°. An “intermediate” behaviour was observed in 12 prostheses with inversion of the scapulohumearl rhythm. The glenohumeral mobility was decreased due to the absence of extraprosthetic mobility (eight cases) or intraprosthetic mobility (four cases). Mean anterior elevation in these shoulders was 80.83°. When the elevation behaviour was “normal”, the Constant score at last follow-up was significantly better compared with “intermediate” (p = 0.008) or “paradoxical” (p = 0.0001) behaviour. Three types of biomechanical behaviour were also observed for rotation movements: a “chronological “ behaviour was observed for 15 prostheses, via extraprosthetic mobility in all. Mean external rotation was 37.33° and mean internal rotation was 6.53 points. An “anarchic” behaviour was observed in 16 prostheses with a random proportion of intra- and extraprosthetic mobility. Mean external rotation was 8.75° and mean internal rotation was 4.25 points. For shoulders with “chronological” or “anarchic” behaviour, the mean external rotation (p = 0.002) and the mean internal rotation (0.04) were statistically better than shoulders with “truncated” behaviour. Discussion: An atrophic deltoid, mediocre joint congruency, and early-stage excentred scapular degeneration with preserved glenoid bone stock are factors favouring “paradoxical” elevation. Deltoid atrophy alone favours “truncated” rotation. This study was helpful in identifying conditions most appropriate for implanting this type of prosthesis and factors predicting postoperative outcome

Introduction. Osteoarthritis (OA) of the knee, a prevalently degenerative joint disorder provoked by articular cartilage loss, accounts for the leading cause of total knee arthroplasty. Autophagy is an indispensable intracellular event that maintains chondrocyte survival and metabolism. MicroRNAs are non-coding small RNAs participating in tissue morphogenesis, remodeling, and homeostasis. This study was undertaken to investigate the effect of microRNA-128 (miR-128) knockdown on the development of OA knees. Materials/Methods. Knee joints in rats were subjected to anterior cruciate ligament transection (ACLT) for inducing OA. Articular cartilage, synovium, and subchondral bone microarchitecture were assessed by OARSI scoring system, histomorphometry, and μCT imaging. Chondrocyte autophagy in terms of the expression of autophagic markers Atg4, Atg12, microtubule-associated protein 1 light chain 3 (LC3), and autophagosome formation was verified. Expression of microRNA, mRNA and signaling transduction were quantified with in situ hybridization, RT- quantitative PCR, and immunoblotting. Results. Chondrocytes in the affected knees showed weak expression of autophagic markers Atg4, Atg12, and LC3-II abundances in conjunction with significant increases in OARSI scores and a 2.5-fold elevation in miR-128 expression. The gain of miR-128 signaling in intact joints through intra-articular injection of miR-128 precursor resulted in 1.8–2.1-fold elevations in serum cartilage breakdown products CTX-II and COMP concentrations. miR-128 overexpression caused the joints to show evident chondrocyte apoptosis as evidenced by TUNEL staining concomitant with severe cartilage damage. Of note, antisense oligonucleotide knockdown of miR-128 (miR-128-AS) enabled the affected knee joints to show minor responses to the ACLT escalation of autophagy dysfunction in chondrocytes, cartilage breakdown histopathology, and OARSI scores. Administration with miR-128-AS also attenuated the ACLT-induced synovial membrane thickening, hyper-angiogenesis, and hypercellularity, which subsequently alleviated osteophyte accumulation, subchondral plate destruction, and trabecular microstructure loss. Conclusion. miR-128 signaling impairs chondrocyte autophagy, which ramps up chondrocyte apoptosis and OA knee development. This study highlights an emerging miR-128 knockdown strategy that sustains cartilage microarchitecture integrity and thereby delays OA knee pathogenesis

Aims

Surgical approaches that claim to be minimally invasive, such as the direct anterior approach (DAA), are reported to have a clinical advantage, but are technically challenging and may create more injury to the soft-tissues during joint exposure. Our aim was to quantify the effect of soft-tissue releases on the joint torque and femoral mobility during joint exposure for hip resurfacing performed via the DAA.

Background. Glenoid component aseptic loosening is the most common source of total shoulder arthroplasty (TSA) revision. In an attempt to strengthen cemented glenoid component fixation, divergent pegged glenoids were designed. Divergent peg creation was intended to increase cement purchase and provide resistance to component rocking. Methods. Thirty-four patients who underwent divergent peg TSA had data collected prospectively. The data from these patients was retrospectively reviewed, primarily for radiographic evidence of glenoid component loosening. The endpoint was defined as the need for revision secondary to glenoid loosening. Secondary outcome measures such as SPADI (shoulder pain and disability index), active forward elevation, abduction, internal rotation, and external rotation were also collected. Data was obtained preoperatively and at the following postoperative intervals: 3 months, 6 months, and yearly. The last available postoperative radiographs were also reviewed and graded on a modified Franklin glenoid lucency scale described by Lazarus et al. Results. The mean follow-up was 5.6 years ± 2.44 (range, 2–10 years). Of the 34 patients in the study, 20 patients had radiographs available for review. Radiographs showed complete lucency around one or less pegs in 14/20 patients (grade 0–2). Six out of twenty glenoids had complete radiolucency around two or more pegs with gross loosening seen in one shoulder (grade 3–5). No secondary surgery was performed in any patients. Significant improvements were seen in active elevation 30.2 degrees ±44.3 (p=0.043) at the last follow up. Improvement was also seen in internal rotation of 4.3 levels ± 4.9 (p=0.016) at the last follow-up. The mean postoperative SPADI score decreased by 48.1 points (p=0.039). Conclusions. Patients with divergent pegged glenoid TSA showed significant improvement in postoperative shoulder elevation, internal rotation, and SPADI scores at final follow-up. No patients underwent revision. However, there were a significant number of patients with radiolucency seen around 2 or more pegs

Participation in a physical therapy program is considered one of the greatest predictors for successful conservative management of common shoulder disorders, however, adherence to standard exercise protocols is often poor (around 50%) and typically worse for unsupervised home exercise programs. Currently, there are limited tools available for objective measurement of adherence and performance of shoulder rehabilitation in the home setting. The goal of this study was to develop and evaluate the potential for performing home shoulder physiotherapy monitoring using a commercial smartwatch. We hypothesize that shoulder physiotherapy exercises can be classified by analyzing the temporal sequence of inertial sensor outputs from a smartwatch worn on the extremity performing the exercise. Twenty healthy adult subjects with no prior shoulder disorders performed seven exercises from a standard evidence-based rotator cuff physiotherapy protocol: pendulum, abduction, forward elevation, internal/external rotation and trapezius extension with a resistance band, and a weighted bent-over row. Each participant performed 20 repetitions of each exercise bilaterally under the supervision of an orthopaedic surgeon, while 6-axis inertial sensor data was collected at 50 Hz from an Apple Watch. Using the scikit-learn and keras platforms, four supervised learning algorithms were trained to classify the exercises: k-nearest neighbour (k-NN), random forest (RF), support vector machine classifier (SVC), and a deep convolutional recurrent neural network (CRNN). Algorithm performance was evaluated using 5-fold cross-validation stratified first temporally and then by subject. Categorical classification accuracy was above 94% for all algorithms on the temporally stratified cross validation, with the best performance achieved by the CRNN algorithm (99.4± 0.2%). The subject stratified cross validation, which evaluated classifier performance on unseen subjects, yielded lower accuracies scores again with CRNN performing best (88.9 ± 1.6%). This proof-of concept study demonstrates the feasibility of a smartwatch device and machine learning approach to more easily monitor and assess the at-home adherence of shoulder physiotherapy exercise protocols. Future work will focus on translation of this technology to the clinical setting and evaluating exercise classification in shoulder disorder populations

Aims. To present our experience of using a combination of intra-articular osteotomy and external fixation to treat different deformities of the knee. Patients and Methods. A total of six patients with a mean age of 26.5 years (15 to 50) with an abnormal hemi-joint line convergence angle (HJLCA) and mechanical axis deviation (MAD) were included. Elevation of a tibial hemiplateau or femoral condylar advancement was performed and limb lengthening with correction of residual deformity using a circular or monolateral Ilizarov frame. Results. At a mean follow-up of 2.8 years (1.5 to 4.1), the mean HJLCA improved from 15.6° (10° to 23°) pre-operatively to 0.4° (0° to 2°). The mean MAD improved from 70.0 mm (20.1 to 118.5) pre-operatively to 9.1 mm (3 to 15). The mean tibiofemoral angle improved from 31.0° (8° to 54°) pre-operatively to 4.9° (2° to 8°). The mean limb-length discrepancy decreased from 6.3 cm (2.9 to 13.6) pre-operatively to 1.1 cm (0 to 5). All osteotomies and distraction zones healed without complications. Conclusion. The use of intra-articular corrective osteotomies combined with the Ilizarov technique allowed correction of deformities of the knee joint with satisfactory HJLCA and overall mechanical axis in six patients with a good functional and cosmetic outcome in the short term. Cite this article: Bone Joint J 2017;99-B:204–10

The outcome of 56 children (61 shoulders) treated surgically at the Rizzoli Institute between April 1975 and June 2010 for congenital elevation of the scapula is reported. There were 31 girls and 25 boys with a mean age at surgery of 6.4 years (2 to 15). The deformity involved the right shoulder in 20 cases, the left in 31 and was bilateral in five. The degree of the deformity was graded clinically and radiologically according to the classifications of Cavendish and Rigault, respectively. All patients underwent a modified Green procedure combined, in selected cases, with resection of the superomedial portion of the scapula and excision of any omovertebral connection. After a mean follow-up of 10.9 years (1 to 29.3), there was cosmetic improvement by at least one Cavendish grade in 54 shoulders (88.5%). The mean abduction of the shoulder improved from 92° (50° to 155°) to 112° (90° to 170°) and the mean flexion improved from 121° (80° to 160°) to 155° (120° to 175°). The unsatisfactory cosmetic result in seven shoulders was due to coexistent scoliosis in two cases and insufficient reduction of the scapular elevation in the other five. An incomplete upper brachial plexus palsy occurred post-operatively in three patients but resolved within seven months. We suggest that a modified Green procedure combined with resection of the superomedial portion of the scapula provides good cosmetic and functional results in patients with Sprengel’s shoulder

Purpose: The serratus anterior, innervated by the Charles Bell nerve, contributes to dynamic abduction and elevation of the shoulder by stabilising the scapula on the thorax. Abduction and elevation beyond 90° or movement of the spinal border of the scapula is impossible in case of serratus anterior paralysis. Material and methods: This series included 16 patients with traumatic damage to the Charles Bell nerve leading to unique paralysis of the serratus anterior. Mean age of the patients at diagnosis was 27.5 years. Nine patients underwent scapulothoracic arthrodesis or scapulopexia and seven patients were not operated due to spontaneous total or partial recovery. Results: Initial elevation in the non operated group was 125°. At five years elevation was 145°, Constant score was 85, and shoulder abduction force was 12 kg (83% of the contralateral force). Final outcome was very good in four patients, good in one, fair in one and poor in one (the fair and poor outcomes involved severe pain for one and major loss of force for the other). Preoperative elevation in the operated group was 95°, reaching 104° at last follow-up. At four years, elevation was 104°, Constant score was 75, and shoulder abduction force was 9 kg (72% of the contralateral force). One case of infection required revision and healed satisfactorily. Outcome was very good in six patients and good in three. Discussion: Several types of treatment can be proposed: non-surgical care, muscle transfer basically with the pectoralis major, and scapulothoracic arthrodesis. The principal series reported in the literature on scapulothoracic arthrodesis concern patients with fascioscapulohumeral dystrophy and are not comparable with our series. It would be possible to compare our patients with series of post-trauma paralysis using muscle transfer which have given good results for mobility but limited improvement in global muscle force. In our patients, scapulothoracic arthrodesis gave good results in terms of muscle force, pain and overall shoulder function; mobility was fixed by the position of the scapula in the arthrodesis. We advocate this method for the treatment of serratus anterior paralysis mainly in manual labourers

Aims. Modular dual mobility (DM) prostheses in which a cobalt-chromium liner is inserted into a titanium acetabular shell (vs a monoblock acetabular component) have the advantage of allowing supplementary screw fixation, but the potential for corrosion between the liner and acetabulum has raised concerns. While DM prostheses have shown improved stability in patients deemed ‘high-risk’ for dislocation undergoing total hip arthroplasty (THA), their performance in young, active patients has not been reported. This study’s purpose was to assess clinical outcomes, metal ion levels, and periprosthetic femoral bone mineral density (BMD) in young, active patients receiving a modular DM acetabulum and recently introduced titanium, proximally coated, tapered femoral stem design. Patients and Methods. This was a prospective study of patients between 18 and 65 years of age, with a body mass index (BMI) < 35 kg/m. 2. and University of California at Los Angeles (UCLA) activity score > 6, who received a modular cobalt-chromium acetabular liner, highly crosslinked polyethylene mobile bearing, and cementless titanium femoral stem for their primary THA. Patients with a history of renal disease and metal hardware elsewhere in the body were excluded. A total of 43 patients (30 male, 13 female; mean age 52.6 years (. sd. 6.5)) were enrolled. All patients had a minimum of two years’ clinical follow-up. Patient-reported outcome measures, whole blood metal ion levels (ug/l), and periprosthetic femoral BMD were measured at baseline, as well as at one and two years postoperatively. Power analysis indicated 40 patients necessary to demonstrate a five-fold increase in cobalt levels from baseline (alpha = 0.05, beta = 0.80). A mixed model with repeated measures was used for statistical analysis. Results. Mean Harris Hip Scores improved from 54.1 (. sd. 20.5) to 91.2 (. sd. 10.8) at two years postoperatively (p < 0.001). All patients had radiologically well-fixed components, no patients experienced any instability, and no patients required any further intervention. Mean cobalt levels increased from 0.065 ug/l (. sd. 0.03) preoperatively to 0.30 ug/l (. sd. 0.51) at one year postoperatively (p = 0.01) but decreased at two years postoperatively to 0.16 ug/l (. sd. 0.23; p = 0.2). Four patients (9.3%) had a cobalt level outside the reference range (0.03 ug/l to 0.29 ug/l) at two years postoperatively, with values from 0.32 ug/l to 0.94 ug/l. The mean femoral BMD ratio was maintained in Gruen zones 2 to 7 at both one and two years postoperatively using this stem design. At two years postoperatively, mean BMD in the medial calcar was 101.5% of the baseline value. Conclusion. Use of a modular DM prosthesis and cementless, tapered femoral stem has shown encouraging results in young, active patients undergoing primary THA. Elevation in mean cobalt levels and the presence of four patients outside the reference range at two years postoperatively demonstrates the necessity of continued surveillance in this cohort. Cite this article: Bone Joint J 2019;101-B:365–371

We compared inflammation in the knee after total knee replacement (TKR) for primary osteoarthritis between two groups of patients undergoing joint replacement with and without synovectomy. A total of 67 patients who underwent unilateral TKR were randomly divided into group I, TKR without synovectomy, and group II, TKR with synovectomy. Clinical outcomes, serial serum inflammatory markers (including interleukin-6 (IL-6), CRP and ESR) and the difference in temperature of the skin of the knee, compared with the contralateral side, were sequentially evaluated until 26 weeks after surgery. Pre-operatively, there were no statistically different clinical parameters between groups I and II. At the 26-week follow-up, both groups had a similarly significantly improved American Knee Society clinical score (p < 0.001) and functional score (p < 0.001) with no differences between the groups. Similar changes in serial inflammatory markers were found in both groups, including mean peak levels of IL-6 (189 pg/ml (. sd. 53.4) versus 201 pg/ml (. sd. 49.4) for groups I and II, respectively) and CRP (91 mg/L (. sd. 24.1) versus 88 mg/L (. sd. 23.4), respectively) on the first post-operative day, returning to pre-operative values at two and six weeks, respectively. The mean peak level of ESR for the respective two groups was 46 mm/hr versus 48 mm/hr at two weeks, which had still not returned to its pre-operative mean value at 26 weeks. The elevation in the skin temperature appeared to mirror the peak elevation of the ESR, with a range of 2.5° C to 4.5° C with some reduction at 26 weeks but still exceeding the pre-operative value. We concluded that synovectomy at the time of TKR does not provide any benefit to the clinical outcome or shorten the duration of the inflammatory response after surgery

Aims

An objective technological solution for tracking adherence to at-home shoulder physiotherapy is important for improving patient engagement and rehabilitation outcomes, but remains a significant challenge. The aim of this research was to evaluate performance of machine-learning (ML) methodologies for detecting and classifying inertial data collected during in-clinic and at-home shoulder physiotherapy exercise.

Aims

To investigate the risk factors for unsuccessful radial head reduction (RHR) in children with chronic Monteggia fractures (CMFs) treated surgically.

Aims

The aim of this study was to longitudinally compare the clinical and radiological outcomes of anatomical total shoulder arthroplasty (aTSA) up to long-term follow-up, when using cemented keel, cemented peg, and hybrid cage peg glenoid components and the same humeral system.

Aims

Osteosarcoma is the most common primary bone malignancy among children and adolescents. We investigated whether benzamil, an amiloride analogue and sodium-calcium exchange blocker, may exhibit therapeutic potential for osteosarcoma in vitro.

Introduction. The aim of this study was to quantify mid-flexion laxity in a total knee arthroplasty with an elevated joint line, as compared to a native knee and a TKA with joint line maintained. Our hypothesis was joint line elevation of 4mm would increase coronal plane laxity throughout mid-flexion in a pattern distinct from the preoperative knee or in a TKA with native joint line. Methods. Six fresh-frozen cadaver legs from hip-to-toe underwent TKA with a posterior stabilised implant (APEX PS, OMNIlife Science, Inc.) using a computer navigation system equipped with a robotic cutting-guide, in this controlled laboratory cadaveric study. After the initial tibial and femoral resections were performed, the flexion and extension gaps were balanced using navigation, and a 4mm recut was made in the distal femur. The remaining femoral cuts were made, the femoral component was downsized by resecting an additional 4mm of bone off the posterior condyles, and the polyethylene was increased by 4mm to create a situation of a well-balanced knee with an elevated joint line. The navigation system was used to measure overall coronal plane laxity by measuring the mechanical alignment angle at maximum extension, 30, 45, 60 and 90(of flexion, when applying a standardised varus/valgus load of 9.8Nm across the knee using a 4kg spring-load located at 25cm distal to the knee joint line. Laxity was also measured in the native knee, as well as the native knee after a standard approach during TKA which included a medial release. Coronal plane laxity was defined as the absolute difference (in degrees) between the mean mechanical alignment angle obtained from applying a standardised varus and valgus stress at 0, 30, 45, 60 and 90(. Results. In full extension, 30(, 45(, 60(, and 90(of flexion, the native knee showed coronal plane laxity of 2.4, 6.5, 7.0, 7.8, and 9.5(, respectively. The above soft tissue releases produced increased laxity in extension and 30(of flexion. After TKA, the mean coronal plane motion was decreased at all flexion angles and remained consistent throughout arc of motion. With 4mm of joint line elevation, coronal-plane laxity increased by a mean of 1.4° at 30° of flexion (p=.0.0103), 1.5° at 45° of flexion (p=.0.0001), and 1.3° at 60° of flexion (p=0.0018) compared to the TKA with native joint line. Conversely, there was no difference in laxity at 0° and 90° between the initial TKA and after 4mm joint line elevation. Conclusions. The computer navigated, well balanced TKA with a maintained joint line showed consistent coronal plane laxity throughout all flexion angles, while the native knee showed greater laxity at 90° than in mid-flexion. Further, as suggested by retrospective clinical reports, this cadaver study confirms that joint line elevation of only 4mm results in greater coronal plane laxity in mid-flexion. These finding suggest that maintaining the joint line in TKA is necessary to avoid increased mid-flexion, coronal plane laxity

As reverse total shoulder arthroplasty (RTSA) systems expand with longer durations in vivo, so does the concern and potential complications of wear, debris and osteolysis. Despite some other profound attempts, no wear testing method has stood out to compare implants across systems and labs. The main reasons may have been the diverse sources of forces and motions used in testing, widely different wear amounts which resulted and the general lack of dedicated shoulder simulators. To add a dedicated shoulder simulator to hip and knee simulators would burden the resources of any testing lab. In this study we propose a shoulder wear test method which addresses the above. Harnessing the wealth of force-motion data from telemetrized shoulder implants from the Bergman's group in Berlin, we synthesized their results to devise a wholistic multi-axes simulation regime for reverse shoulders. The alignment and motions of the humeral cup and the glenosphere were kept anatomically correct (relative to each other) and yielded a physiologically realistic wear-inducing articulation. However, we opted for a very unusual installation/orientation of the whole implant system to allow a twelve station AMTI (hip) simulator to be adapted for this study. The shoulder constructs were aligned with novel fixtures such that the machine's vertical compressive force mimicked the average forces of the shoulder found from the in vivo telemetry data in magnitude and nominal direction. Aligned thus, a patient with a shoulder installed would neither stand, nor lie down, but be oriented in a composite angle relative the simulator original axes. Each anatomic shoulder motion would be achieved by unique computed combinations of the three simulator motion actuators, none of which would be aligned anatomically for the shoulder on its own. The maximum ranges of cyclic shoulder motion achieved with the constraints of the simulator were 38°–79° of forward elevation repeated in two separate (15°and 45°) elevation planes. The change of elevation plane inherently involved abduction-adduction motion, and simultaneously also involved variation of internal-external rotation within a 57° range. Each elevation rise (twice per cycle) was also accompanied by a sinusoidally rising and falling compressive load in the range 50N–1700N. The test method was tested (!) by simulating for 2.5 million of the above (double-elevation) cycles and gravimetrically measuring wear of twelve 36 mm size RTSA systems. We compared six systems having vitamin E-infused highly cross-linked polyethylene bearings (100 kGy radiation) to six controls with a medium cross-linked polyethylene of half the radiation dose. Significant wear resulted for the control bearing material (average 17.9 ± 0.851 mg/MC) which was no less than many hips and knees. Multiply (and statistically significantly, p < 0.001) less average wear (3.42 ± 0.22 mg/MC) resulted for the highly cross linked bearings. The above demonstrated the effectiveness of the test method. Significant wear resulted under physiologically realistic cyclic motion and forces with strong discrimination between two systems whose bearing materials were known to be different in resilience to wear. Using novel fixtures and unusual orientation to utilize a standard commercially available joint simulator promises efficacy of the test method and utility across different labs