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Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_10 | Pages 6 - 6
1 Aug 2021
Kennedy I Hrycaiczuk A Ng N Sheerins O Patil S Jones B Stark A Meek D
Full Access

Periprosthetic fractures (PPF) of the femur following total hip arthroplasty represent a significant complication with a rising incidence. The commonest subtype is Vancouver B2 type, for which revision to a long uncemented tapered fluted stem is a widely accepted management. In this study we compare this procedure to the less commonly performed cement-in-cement revision.

All patients undergoing surgical intervention for a Vancouver B2 femoral PPF in a cemented stem from 2008 – 2018 were identified. We collated patient age, gender, ASA score, BMI, operative time, blood transfusion requirement, change in haemoglobin (Hb) level, length of hospital stay and last Oxford Hip Score (OHS). Radiographic analysis was performed to assess time to fracture union and leg length discrepancy. Complications and survivorship of implant and patients were recorded.

43 uncemented and 29 cement-in-cement revisions were identified. There was no difference in patient demographics between groups. A significantly shorter operative time was found in the cement-in-cement group, but there was no difference in transfusion requirement, Hb change, or length of hospital stay. OHS was comparable between groups. A non-significant increase in overall complication rates was found in the revision uncemented group, with a significantly higher dislocation rate. Time of union was comparable and there were no non-unions in the cement-in-cement group. A greater degree of stem subsidence was found in the uncemented group. There was no difference in any revision surgery required in either group. Three patients in the uncemented group died in the perioperative period, compared to none in the cement-in-cement group.

With appropriate patient selection, both cement-in-cement and long uncemented tapered stem revision represent appropriate treatment options for Vancouver B2 fractures.


Bone & Joint Research
Vol. 9, Issue 6 | Pages 272 - 278
1 Jun 2020
Tapasvi S Shekhar A Patil S Pandit H

Aims

The mobile bearing Oxford unicompartmental knee arthroplasty (OUKA) is recommended to be performed with the leg in the hanging leg (HL) position, and the thigh placed in a stirrup. This comparative cadaveric study assesses implant positioning and intraoperative kinematics of OUKA implanted either in the HL position or in the supine leg (SL) position.

Methods

A total of 16 fresh-frozen knees in eight human cadavers, without macroscopic anatomical defects, were selected. The knees from each cadaver were randomized to have the OUKA implanted in the HL or SL position.


Bone & Joint Research
Vol. 7, Issue 1 | Pages 103 - 104
1 Jan 2018
Young PS Patil S Meek RMD


The Bone & Joint Journal
Vol. 99-B, Issue 4 | Pages 445 - 450
1 Apr 2017
Marsh AG Nisar A El Refai M Patil S Meek RMD

Aims

The purpose of this study was to evaluate whether an innovative templating technique could predict the need for acetabular augmentation during primary total hip arthroplasty for patients with dysplastic hips.

Patients and Methods

We developed a simple templating technique to estimate acetabular component coverage at total hip arthroplasty, the True Cup: False Cup (TC:FC) ratio. We reviewed all patients with dysplastic hips who underwent primary total hip arthroplasty between 2005 and 2012. Traditional radiological methods of assessing the degree of acetabular dysplasia (Sharp’s angle, Tönnis angle, centre-edge angle) as well as the TC:FC ratio were measured from the pre-operative radiographs. A comparison of augmented and non-augmented hips was undertaken to determine any difference in pre-operative radiological indices between the two cohorts. The intra- and inter-observer reliability for all radiological indices used in the study were also calculated.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 114 - 114
1 May 2016
D'Lima D Colwell C Hsu A Bunn A Patil S
Full Access

Background

Despite the success of total knee arthroplasty (TKA) restoration of normal function is often not achieved. Soft-tissue balance is a major factor leading to poor outcomes including malalignment, instability, excessive wear, and subluxation. Mechanical ligament balancers only measure the joint space in full extension and at 90° flexion. This study uses a novel electronic ligament balancer to measure the ligament balance in normal knees and in knees after TKA to determine the impact on passive and active kinematics.

Methods

Fresh-frozen cadaver legs (N = 6) were obtained. A standard cruciate-retaining TKA was performed using measured resection approach and computer navigation (Stryker Navigation, Kalamazoo, MI).

Ligament balance was measured using a novel electronic balancer (Fig 1, XO1, XpandOrtho, Inc, La Jolla, CA, USA). The XO1 balancer generates controlled femorotibial distraction of up to 120N. The balancer only requires a tibial cut and can be used before or after femoral cuts, or after trial implants have been mounted. The balancer monitors the distraction gap and the medial and lateral gaps in real time, and graphically displays gap measurements over the entire range of knee flexion. Gap measurements can be monitored during soft-tissue releases without removing the balancer.

Knee kinematics were measured during active knee extension (Oxford knee rig) and during passive knee extension under varus and valgus external moment of 10Nm in a passive test rig.

Sequence of testing and measurement:

Ligament balance was recorded with the XO1 balancer after the tibial cut, after measured resection of the femur, and after soft-tissue release and/or bone resection to balance flexion-extension and mediolateral gaps.

Passive and active kinematics were measured in the normal knee before TKA, after measured resection TKA, and after soft-tissue release and/or bone resection to balance flexion-extension and mediolateral gaps.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_3 | Pages 72 - 72
1 Jan 2016
Nagamine R Weijia C Patil S D'Lima D Todo M
Full Access

Introduction

The effect of each step of medial soft tissue release was assessed taking the expansion strength and patellar condition into account in five fresh frozen normal cadaver specimens.

Methods

In each cadaver specimen, only proximal tibia was cut. Then, ACL was cut, and deep MCL fiber was released. This condition was set as “the basic”. Joint gap distance and angle were measured at full extension, 30°, 60°, 90°, 120° flexion and in full flexion. The measurement was firstly done with the standard tensor/balancer with the patella everted, and the next with the offset tensor/balancer with the patella reduced. The torque of 10, 20 and 30 inch-pounds were applied through the specialized torque wrench. After the measurement in “the basic”, PCL, MCL superficial fibres, pes anserinus and semi-membranosus were released step by step. Measuring the joint gap distance and angle with the same scheme above were conducted after the each step.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 103 - 103
1 Jan 2016
D'Lima D Patil S Bunn A Colwell C
Full Access

Background

Despite the success of total knee arthroplasty (TKA) restoration of normal function is often not achieved. Soft tissue balance is a major factor for poor outcomes including malalignment, instability, excessive wear, and subluxation. Computer navigation and robotic-assisted systems have increased the accuracy of prosthetic component placement. On the other hand, soft tissue balancing remains an art, relying on a qualitative feel for the balance of the knee, and is developed over years of practice

Several instruments are available to assist surgeons in estimating soft tissue balance. However, mechanical devices only measure the joint space in full extension and at 90° flexion. Further, because of lack of comprehensive characterization of the ligament balance of healthy knees, surgeons do not have quantitative guidelines relating the stability of an implanted to that of the normal knee. This study measures the ligament balance of normal knees and tests the accuracy of two mechanical distraction instruments and an electronic distraction instrument.

Methods

Cadaver specimens were mounted on a custom knee rig and on the AMTI VIVO which replicated passive kinematics. A six-axis load cell and an infrared tracking system was used to document the kinematics and the forces acting on the knee.

Dynamic knee laxity was measured under 10Nm of varus/valgus moment, 10Nm of axial rotational moment, and 200N of AP shear. Measurements were repeated after transecting the anterior cruciate ligament, after TKA, and after transecting the posterior cruciate ligament.

The accuracy and reproducibility of two mechanical and one electronic distraction device was measured.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 52 - 52
1 Nov 2015
Marsh A Kennedy I Nisar A Patil S Meek R
Full Access

Introduction

Cement in cement revision with preservation of the original cement mantle has become an attractive and commonly practised technique in revision hip surgery. Since introducing this technique to our unit we have used two types of polished tapered stem. We report the clinical and radiological outcomes for cement in cement femoral revisions performed using these prostheses.

Materials and Methods

All patients who underwent femoral cement in cement revision with a smooth tapered stem between 2005 –2013 were assessed. Data collected included indication for revision surgery and components used. All patients were followed up annually. Outcomes recorded were radiographic analysis, clinical outcome scores (Oxford Hip Score, WOMAC and SF-12) and complications, including requirement for further revision surgery. Median follow-up was 5 years (range 1 – 8 years).

116 revision procedures utilising cement in cement femoral revision were performed in the 8 year study period (68 females, 48 males, and mean age of 69 years). The femoral component was a C-stem AMT (Depuy) in 59 cases and Exeter stem (Stryker) in 57 cases.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_3 | Pages 5 - 5
1 Apr 2015
Al Fakayh O Marsh A Patil S
Full Access

Ganz peri-acetabular osteotomy is commonly used to treat symptomatic hip dysplasia. It aims to increase the load bearing contact area of the hip to reduce the risk of subsequent osteoarthritis. In this study we assess the radiographic and clinical results of the procedure since its introduction to our unit.

All patients undergoing Ganz osteotomies at our unit were followed up prospectively. Data collected included patient demographics and pre- and post-operative functional scores (Harris and Non-arthritic hip scores). In addition, acetabular correction was evaluated on pre-and post-operative radiographs (using Centre-Edge angle and Tonnis angle). Complications were also noted.

Overall 50 procedures were performed between 2007 and 2013 with median follow-up of 3 years (1 – 7 years). The majority of patients (90%) were female. Average age at time of surgery was 29 years (16–49). There were significant improvements in pre- and post-operative median functional scores (Modified Harris Hip Score = 49 versus 64, p=0.001), Non-arthritic Hip Score = 42 versus 56, p=0.007). Median Centre Edge Angle improved from 16 degrees pre-operatively (range = 7–31 degrees) to 30 degrees post-operatively (18–33) degrees), p<0.0001. Similarly, pre-operative Tonnis angle improved from 18 degrees (9–38) to 7 degrees (2–14), p<0.0001. Five patients developed post-operative complications: 2 superficial wound infection, 1deep infection requiring hip washout and antibiotic treatment and 2 patients subsequently requiring total hip replacements.

We have shown that the Ganz peri-acetabular osteotomy can be effective for the treatment of painful hip dysplasia improving both functional and radiographic outcomes. However, patient selection is a key factor.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_3 | Pages 14 - 14
1 Apr 2015
Halai M Augustine A Holloway N MacDonald D Mohammed A Meek R Patil S
Full Access

Two major challenges in arthroplasty are obesity and antibiotic resistance. This study was performed to characterise the organisms responsible for deep infection following total hip arthroplasty and to determine if obesity affected the microbiology profile.

A retrospective analysis of the national surgical site infection register was made to obtain data regarding deep infection following 10948 primary total hip arthroplasty (THA) from 1998–2013, with a minimum of 2 year follow-up.

Of all the primary THAs performed, there were 108 deep infections (56 patients had a BMI >30 (obese) and 52 patients <30). There were no significant differences between cardio-respiratory disease, smoking and alcohol status, and diabetes between the 2 groups. Over the last 15 years, staphylococcus aureus continues to be the most frequently isolated organism. Infection with multiple organisms was found exclusively in obese patients. Furthermore, in obese patients, there was a linear increase with methicillin resistant staphylococcus aureus (MRSA) infections and streptococcus viridans.

On this basis, we recommend careful selection of antibiotic therapy in obese patients, rather than empirical therapy, which can be especially important if there is no growth in an infected THA. In addition, a preoperative discussion regarding dental prophylaxis against streptococcus viridans may be warranted.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_3 | Pages 12 - 12
1 Apr 2015
Bradman H Patil S Martin D Marsh A
Full Access

Postgraduate training in orthopaedics has traditionally been delivered through an apprenticeship model. However, junior doctor working patterns have more recently moved away from a team based structure, potentially affecting training experience. We aimed to compare the perceived quality of training between medical students, junior non-orthopaedic trainees and orthopaedic specialty trainees.

We conducted an anonymous questionnaire of all medical students and trainees rotating through our unit over 24 months. The questionnaire contained 6, 10-point Likert rating scale questions and free text responses. Results were collated and analysed according to training stage.

Of 82 questionnaires distributed, 60 (73%) were completed (18 specialty registrars, 22 junior trainees and 20 medical students). Junior trainees consisted of 8 GPSTs and 14 Foundation Year (FY2) doctors, only one of whom had specifically chosen an orthopaedic placement.

Median Likert rating of training experience was (1 = very poor, 10 = excellent): ST4-ST8 = 8 (range 7–9), ST1-ST3 = 7 (6–9), GPSTs/FY2s = 4 (2–5) and medical students = 8 (7–10). Further analysis of junior non-orthopaedic doctors' training experience showed that placement induction, organisation of formal teaching and opportunities for training out with formal sessions were rated as poor. However, content of delivered teaching was rated highly. Free text responses identified several barriers to training including being too busy on wards and no opportunity for protected teaching.

Our study shows that junior non-orthopaedic trainees feel their training experience during orthopaedic placements is much poorer than orthopaedic trainees and medical students. Time constraints and less team based working patterns may detract from their teaching opportunities. In addition, junior doctors rotating through orthopaedic units now have a wider spectrum of career interests with heterogeneous training needs. Therefore, orthopaedic departments may need to adopt a more targeted training programme that recognises individual training needs if junior doctor training is to improve.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_14 | Pages 11 - 11
1 Oct 2014
Marsh A Al Fakayh O Patil S
Full Access

Ganz peri-acetabular osteotomy is commonly used to treat symptomatic hip dysplasia. It aims to increase the load bearing contact area of the hip to reduce the risk of subsequent osteoarthritis. In this study we assess the radiographic and clinical results of the procedure since its introduction to our unit.

All patients undergoing Ganz osteotomies at our unit were followed up prospectively. Data collected included patient demographics and pre- and post-operative functional scores (Harris and Non-arthritic hip scores). In addition, acetabular correction was evaluated on pre-and post-operative radiographs (using Centre-Edge angle and Tonnis angle). Complications were also noted.

Overall 50 procedures were performed between 2007 and 2013 with median follow-up of 3 years (1–7 years). The majority of patients (90%) were female. Average age at time of surgery was 32 years (17–39). There were significant improvements in pre- and post-operative median functional scores (Modified Harris Hip Score = 52 versus 63, p=0.001), Non-arthritic Hip Score = 49 versus 60, p=0.01). Median Centre Edge Angle improved from 15 degrees pre-operatively (range = 8–19 degrees) to 29 degrees post-operatively (22–36 degrees), p=0.02. Similarly, pre-operative Tonnis angle improved from 19 degrees (16–38) to 7 degrees (2–14), p=0.01. Four patients developed post-operative complications: 1 superficial wound infection, 1deep infection requiring hip washout and antibiotic treatment and 2 patients subsequently requiring total hip replacements.

We have shown that the Ganz peri-acetabular osteotomy can be effective for the treatment of painful hip dysplasia improving both functional and radiographic outcomes. However, patient selection is a key factor.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_7 | Pages 9 - 9
1 Apr 2014
Marsh A Nisar A El Refai M Meek R Patil S
Full Access

When performing total hip replacements in patients with hip dysplasia, acetabular augmentation may be required to prevent early component failure. Preoperative radiographic templating may help estimate acetabularcomponent coverage but has not previously been shown to predict the need for augmentation.

We developed a simple method to estimate the percentage of acetabular component coverage from pre-operative radiographs (True: False cup ratio). We aimed to evaluate whether this couldpredict the need foracetabular augmentation at primary total hip replacement for patients with dysplastic hips.

We reviewed all patients with hip dysplasia who underwent a primary total hip replacement from 2005–2012. Classification of hip dysplasia (Crowe), centre edge angle (CEA), Sharp and Tonnis angles were determined on pre-operative radiographs for each patient. Templating was performed on anteroposteriorand lateral view hip radiographs to determine the likely percentage of acetabular component coverage using the True: False cup ratio. Patients requiring acetabular augmentation at time of primary total hip arthroplasty were noted.

128 cases were reviewed, 31 (24%) required acetabularaugmentation. Comparison between augmented and non-augmented cases revealed no difference in the mean CEA (p = 0.19), Sharp angles (p = 0.76) or Tonnis angles (p = 0.32). A lower True Cup: False Cup ratio was observed in the augmented groupcompared to the non-augmented group(median = 0.68 vs 0.88, p < 0.01).

Preoperative templating can help predict which dysplastic hips are likely to require acetabular augmentation at primary total hip replacement.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_7 | Pages 16 - 16
1 Apr 2014
Abdelhalim M Gillespie J Patil S
Full Access

Femoroacetabular impingement (FAI) is the result of abnormal contact/impingement of the femoral head-neck junction and acetabulum during motion. This can be corrected by surgical dislocation (using Ganz's trochanteric osteotomy) and femoral osteochondroplasty +/− acetabular rim resection. Our study aimed to assess the improvement in hip scores following open osteochondroplasty to predict outcomes based on patient characteristics.

This was a retrospective case note analysis of a single surgeon case series over a 4 year period. Inclusion criteria were open osteochondroplasty, complete pre- and post-op hip scores available), Tonnis osteoarthritis grade 0 or 1, with 1 year followup. Data was extracted from electronic and paper case notes for pre- and post-op Modified Harris Hip Scores (MHHS), Non-arthritis Hip Scores (NAHS) and SF-12 general satisfaction scores, as well as baseline patient demographics. Two independent observers used the PACS radiology system to examine x-rays and MRI. SPSS version 19 was used for statistical analysis.

42 patients met the inclusion criteria. There was an overall improvement in hip scores after the procedure. Mean pre-op scores were MHHS 52.5, NAHS 44.0, SF-12 32.1. Mean post-op scores were MHHS 66.1, NAHS 58.7, SF-12 36.4. Therefore mean improvements were seen in MHHS (13.6), NAHS (14.7) and SF-12 (4.3), all significant at p<0.005 when paired t-test was used for analysis. Pearson correlation for subgroup analysis showed no significant correlation of scores with age, centre-edge angle or alpha angles. Furthermore, no significant difference was seen between males and females (independent t test).

Open osteochondroplasty improves symptoms and function based on patient reported outcome measures. Although the mean scores improved, some patients’ scores deteriorated. We have not identified any statistically significant predictors of outcome, and therefore patient selection remains unclear.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 40 - 40
1 Dec 2013
D'Lima D Bunn A Patil S Colwell C
Full Access

Introduction:

Kinematic studies are used to evaluate function and efficacy of various implant designs. Given the large variation between subjects, matched pairs are ideal when comparing competing designs. It is logical to deduce that both limbs in a subject will behave identically during a given motion [1], barring unilateral underlying pathology, thus allowing for the most direct comparison of two designs. It is our goal to determine if this is a valid assumption by assessing whether or not there are significant differences present in the kinematics of left and right knees from the same subject. Gait studies have compared pre-and postoperative implantation kinematics for various pathologies like ACL rupture [2] and osteoarthritis [3, 4]. We designed a study to assess squatting in cadaver specimens.

Methods:

Sixteen matched pairs of fresh-frozen cadavers, (Eleven males, five females; aged 71 years [± 10 yrs]) were tested. Each knee, intact, was tested by mounting it on a dynamic, quadriceps-driven, closed-kinetic-chain Oxford knee rig (OKR), which simulated a deep knee bend from full extension to 120° flexion. We chose femoral rollback, tibiofemoral external rotation, tibial adduction, patellofemoral tilt and shift as our outcomes, which were recorded using an active infrared tracking system.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 502 - 502
1 Dec 2013
Robinson J Patil S Rathod P Rodriguez J
Full Access

Introduction:

Subsidence of cementless femoral stems in total hip arthroplasty (THA) has been associated with poor initial fixation and subsequent risk of aspectic loosening. There is limited literature on how subsidence of cementless, proximally porous coated, tapered wedge femoral stems impacts the patient clinically. The aim of our study was to assess whether subsidence with these stems is associated with a decline in clinical function.

Method:

A review of a prospectively collected database of THAs performed by a single surgeon at one institution using two cementless, tapered wedge stem designs from January 2006 to June 2010 was performed. Radiographic analysis using Picture Archiving and Communications System (PACS) was used to identify patients with greater than 1.5 mm of subsidence, and to document osseointegration. Preoperative and postoperative pain and Harris hip scores were recorded; and analyzed to identify if the clinical recovery pattern of the subsidence versus no subsidence groups differed. Protected weight bearing was recommended to all patients with subsidence.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 41 - 41
1 Dec 2013
D'Lima D Patil S Bunn A Bugbee W Colwell C
Full Access

Introduction:

Despite over 95% long-term survivorship of TKA, 14–39% of patients express dissatisfaction due to anterior knee pain, mid-flexion instability, reduction in range of flexion, and incomplete return of function. Changing demographics with higher expectations are leading to renewed interest in patient-specific designs with the goal of restoring of normal kinematics.

Improved imaging and image-processing technology coupled with rapid prototyping allow manufacturing of patient-specific cutting guides with individualized femoral and tibial components with articulating surfaces that maximize bony coverage and more closely approximate the natural anatomy. We hypothesized that restoring the articular surface and maintaining medial and lateral condylar offset of the implanted knee to that of the joint before implantation would restore normal knee kinematics. To test this hypothesis we recorded kinematics of patient-specific prostheses implanted using patient-specific cutting guides.

Methods:

Preoperative CT scans were obtained from nine matched pairs of human cadaveric knees. One of each pair was randomly assigned to one of two groups: one group implanted with a standard off-the-shelf posterior cruciate-retaining design using standard cutting guides based on intramedullary alignment; the contralateral knee implanted with patient-specific implants using patient-specific cutting guides, both manufactured from the preoperative CT scans. Each knee was tested preoperatively as an intact, normal knee, by mounting the knee on a dynamic, quadriceps-driven, closed-kinetic-chain Oxford knee rig (OKR), simulating a deep knee bend from 0° to 120° flexion. Following implantation with either the standard or patient-specific implant, knees were mounted on the OKR and retested. Femoral rollback, tibiofemoral rotation, tibial adduction, patellofemoral tilt and shift were recorded using an active infrared tracking system.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_31 | Pages 4 - 4
1 Aug 2013
Marsh A Nisar A Patil S Meek R
Full Access

Repeat revision hip replacements can lead to severe bone loss necessitating salvage procedures such as proximal or total femoral replacement. We present medium term outcomes from our experience of the Limb Preservation System (LPS) in patients with failed revision hip arthroplasties.

All patients undergoing proximal femoral or total femoral replacement from 2003–2007 at our unit were reviewed. Data was collected preoperatively and at annual assessment post procedure for a minimum of 5 years. This included clinical review, functional outcome scores (WOMAC, Oxford Hip Score, Harris Hip Score) and radiographic evaluation.

A total of 17 patients underwent femoral replacement (13 proximal, 4 total) using the LPS during the study period. Within this cohort there were 13 males and 4 females with a mean age of 64 years (range 47–86). Median follow up was 7 years (range 5–9 years). Primary diagnoses were DDH (7), Primary OA (5), RA (2), proximal femoral fracture (2) and phocomelia (1). Five patients (29%) required further revision surgery for infection (2 patients) or recurrent dislocations (3 patients). No stems required revision due to aseptic loosening or stem failure at 5–9 years. Compared to preoperative assessment, there was significant improvement in median outcome scores at 5 years (WOMAC increased by 33 points, Oxford hip score by16 points and Harris hip score by 43 points). 82% of patients maintained functional independence at latest review.

The Limb Preservation System offers a salvage procedure for failed revision total hip arthroplasty with significant symptom and functional improvement in most patients at medium term follow up.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_30 | Pages 20 - 20
1 Aug 2013
Elias-Jones C Reilly J Kerr S Meek R Patil S Kelly M Campton L McInnes I Millar N
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Femoroacetabular impingement (FAI) is a significant cause of osteoarthritis in young active individuals but the pathophysiology remains unclear. Increasing mechanistic studies point toward an inflammatory component in OA. This study aimed to characterise inflammatory cell subtypes in FAI by exploring the phenotype and quantification of inflammatory cells in FAI versus OA samples.

Ten samples of labrum were obtained from patients with FAI (confirmed pathology) during open osteochondroplasty or hip arthroscopy. Control samples of labrum were collected from five patients with osteoarthritis undergoing total hip arthroplasty. Labral biopsies were evaluated immunohistochemically by quantifying the presence of macrophages (CD68 and CD202), T cells (CD3), mast cells (mast cell tryptase) and vascular endothelium (CD34).

Labral biopsies obtained from patients with FAI exhibited significantly greater macrophage, mast cell and vascular endothelium expression compared to control samples. The most significant difference was noted in macrophage expression (p<0.01). Further sub typing of macrophages in FAI using CD202 tissue marker revealed and M2 phenotype suggesting that these cells are involved in a regenerate versus a degenerate process. There was a modest but significant correlation between mast cells and CD34 expression (r=0.4, p<0.05) in FAI samples.

We provide evidence for an inflammatory cell infiltrate in femoroacetabular impingement. In particular, we demonstrate significant infiltration of mast cells and macrophages suggesting a role for innate immune pathways in the events that mediate hip impingement. Further mechanistic studies to evaluate the net contribution and hence therapeutic utility of these cellular lineages and their downstream processes may reveal novel therapeutic approaches to the management of early hip impingement.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_25 | Pages 7 - 7
1 May 2013
Patil S Goudie S Keating JF Patton S
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Vancouver B fractures around a cemented polished tapered stem (CTPS) are often treated with revision arthroplasty. Results of osteosynthesis in these fractures are poor as per current literature. However, the available literature does not distinguish between fractures around CTPS from those around other stems.

The aim of our study was to assess the clinical and radiological outcome of open reduction and internal fixation in Vancouver B fractures around CTPS using a broad non-locking plate.

Patients treated with osteosynthesis between January 1997 and July 2011 were retrospectively reviewed. All underwent direct reduction and stabilisation using cerclage wires before definitive fixation with a broad DCP. Bicortical screw fixation was obtained in the proximal and distal fragments. We defined failure of treatment as revision for any cause.

101 patients (42 men and 59 women, mean age 79) were included. 70 had minimum follow-up of 6 months. 63 of these went on to clinical and radiological union. Three developed infected non-union. 7 had failure of fixation. Lack of anatomical reduction was the commonest predictor of failure followed by inadequate proximal fragment fixation and infection. 14 patients dropped at least 1 mobility grade from their preoperative status.

This is the largest series of a very specific group of periprosthetic fractures treated with osteosynthesis. Patients who develop these fractures are often frail and “high risk” for major revision surgery. We recommend osteosynthesis for patients with Vancouver B periprosthetic fractures around CTPS provided these fractures can be anatomically reduced and adequately fixed.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_20 | Pages 11 - 11
1 Apr 2013
Hussain S Horey L Meek R Patil S
Full Access

Introduction

The outcome of periacetabular osteotomy in dysplastic hips is dependent on the absence of pre-operative osteoarthritis [OA]. The purpose of this study was to analyze whether Tonnis grading is a reliable predictor of OA in patients with hip dysplasia.

Methods

Thirty patients were identified who had undergone hip arthroscopy surgery to assess their suitability for periacetabular osteotomy. Radiographs were assessed for anterior centre edge angle, lateral centre edge angle, Tonnis angle and Tonnis grade for OA changes. The radiographic grading of OA was compared with arthroscopic findings.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_20 | Pages 20 - 20
1 Apr 2013
Hussain S Horey L Patil S Meek R
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Reconstruction of an acetabulum following severe bone loss can be challenging. The aim of this study was to determine the outcome of acetabular reconstruction performed using trabecular metal shell for severe bone loss.

Between June 2003 and June 2006 a total of 29 patients with significant acetabular bone stock deficiency underwent revisions using trabacular metal shell. According to Paprosky classification, there were 18 patients with grade IIIA and 11 patients with grade IIIB defects. Nineteen patients required augments to supplement the defects. Functional clinical outcomes were measured by WOMAC and Oxford hip. Detailed radiological assessments were also made.

At most recent follow up (average 5.5 years, range 3.5–8.5) the mean Oxford hip score improved from 12 preoperatively to 27.11 postoperatively and WOMAC score from 17.57 preoperatively to 34.14 postoperatively The osseointegration was 83% according to Moore's classification. There were two reoperations; one was for instability, and one for aseptic loosening. One patient has a chronic infection and one had a periprosthetic fracture, both treated conservatively.

Despite challenges faced with severe preoperative acetabular defects the early results using this technique in Grade III A and B is encouraging.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_13 | Pages 75 - 75
1 Mar 2013
Bone M Langton D Lord J Patil S Partington P Joyce T
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Introduction

There is much current debate concerning wear and corrosion at the taper junctions of large head total hip replacements, particularly metal-on-metal hips. Is such damage a modern concern or has it always occurred in total hip replacement but not previously noted. To investigate this five explanted V40 Exeter femoral stems (Stryker Howmedica) were obtained following revision surgery at a single centre. In all cases, the 24–26 mm femoral heads were still attached.

Hypothesis

In conventional ‘small head’ modular hip prostheses such as the Exeter, negligible wear and corrosion is seen at the taper junction of explanted devices.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 329 - 329
1 Mar 2013
Shimizu N Tomita T Patil S Yamazaki T Iwamoto K Kurita M Fujii M Lima DD Sugamoto K
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Background

The decision to choose CR (cruciate retaining) insert or CS (condylar stabilized) insert during TKA remains a controversial issue. Triathlon CS type has a condylar stabilized insert with an increased anterior lip that can be used in cases where the PCL is sacrificed but a PS insert is not used. The difference of the knee kinematics remains unclear. This study measured knee kinematics of deep knee flexion under load in two insert designs using 2D/3D registration technique.

Materials and methods

Five fresh-frozen cadaver lower extremity specimens were surgically implanted with Triathlon CR components (Stryker Orthopedics, Mahwah, NJ). CR insert with retaining posterior cruciate ligament were measured firstly, and then CS insert after sacrificing posterior cruciate ligament were measured. Under fluoroscopic surveillance, the knees were mounted in a dynamic quadriceps-driven closed-kinetic chain knee simulator based on the Oxford knee rig design. The data of every 10° knee flexion between 0° and 140° were corrected. Femorotibial motion including tibial polyethylene insert were analyzed using 2D/3D registration technique, which uses computer-assisted design (CAD) models to reproduce the spatial position of the femoral, tibial components from single-view fluoroscopic images. We evaluated the knee flexion angle, femoral axial rotation, and anteroposterior translation of contact points.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_10 | Pages 9 - 9
1 Feb 2013
Elias-Jones C Reilly J Kerr S Meek R Patil S Kelly M Campton L McInnes I Millar N
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Femoroacetabular impingement (FAI) is a significant cause of osteoarthritis in young active individuals but the pathophysiology remains unclear. Increasing mechanistic studies point toward an inflammatory component in OA. This study aimed to characterise inflammatory cell subtypes in FAI by exploring the phenotype and quantification of inflammatory cells in FAI versus OA samples.

Ten samples of labrum were obtained from patients with FAI (confirmed pathology) during open osteochondroplasty or hip arthroscopy. Control samples of labrum were collected from five patients with osteoarthritis undergoing total hip arthroplasty. Labral biopsies were evaluated immunohistochemically by quantifying the presence of macrophages (CD68 and CD202), T cells (CD3), mast cells (mast cell tryptase) and vascular endothelium (CD34).

Labral biopsies obtained from patients with FAI exhibited significantly greater macrophage, mast cell and vascular endothelium expression compared to control samples. The most significant difference was noted in macrophage expression (p<0.01). Further sub typing of macrophages in FAI using CD202 tissue marker revealed and M2 phenotype suggesting that these cells are involved in a regenerate versus a degenerate process. There was a modest but significant correlation between mast cells and CD34 expression (r=0.4, p<0.05) in FAI samples.

We provide evidence for an inflammatory cell infiltrate in femoroacetabular impingement. In particular, we demonstrate significant infiltration of mast cells and macrophages suggesting a role for innate immune pathways in the events that mediate hip impingement. Further mechanistic studies to evaluate the net contribution and hence therapeutic utility of these cellular lineages and their downstream processes may reveal novel therapeutic approaches to the management of early hip impingement.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 37 - 37
1 Sep 2012
Patil S Manning M Mizu-uchi H Ezzet K D'Lima D
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Introduction

It is well known that total knee arthroplasty (TKA) does not preserve normal knee kinematics. This outcome has been attributed to alteration of soft-tissue balance and differences between the geometry of the implant design and the normal articular surfaces. Bicompartmental knee arthroplasty (BKA) has been developed to replace the medial and anterior compartments, while preserving the lateral compartment, the anterior cruciate ligament (ACL), and the posterior cruciate ligament (PCL). In a previous study, we reported that unicompartmental knee arthroplasty did not significantly change knee kinematics and attributed that finding to a combination of preservation of soft-tissue balance and minimal alteration of joint articular geometry (Patil, JBJS, 2007). In the present study, we analyzed the effect of replacing trochlear surface in addition to the medial compartment by implanting cadaver knees with a bicompartmental arthroplasty design. Our hypothesis was that kinematics after BCKA will more closely replicate normal kinematics than kinematics after TKA.

Methods

Eight human cadaveric knees underwent kinematic analysis with a surgical navigation system. Each knee was evaluated in its normal intact state, then after BKA with the Deuce design (Smith & Nephew, Memphis, TN), then after ACL sacrifice, and finally after implanting a PCL-retaining TKA (Legion, Smith & Nephew). Knees were tested on the Oxford knee rig, which simulates a quadriceps-driven dynamic deep knee bend. Tibiofemoral rollback and rotation and patellofemoral shift and tilt were recorded for each condition and compared using repeated measures ANOVA for significance.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 17 - 17
1 Sep 2012
Bone M Lord J Patil S Partington P Joyce T
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Background

Hemiarthroplasty of the hip involves the replacement of the femoral side of the joint with a metal prosthesis, resulting in metal-on-cartilage articulation. The two most common types of hemiarthroplasty used are the Austin Moore and the Thomson, both of which are available in either Titanium (Ti) or cobalt chromium (CoCr). Hemiarthroplasty may be more cost effective in elderly patients who have lower life expectancy and are less active.

Materials and Methods

Three Ti and two CoCr hemiarthroplasty components were obtained following revision surgery. Four had an articulating diameter of 44mm and the other was 46mm diameter. These five hemiarthroplasties were analysed using a Mitutoyo LEGEX322 co-ordinate measuring machine (CMM) (manufacturer's claimed scanning accuracy of 0.8μm). In each case a wear map was generated and the wear volume from the articulating surface was calculated using a bespoke MATLAB program.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 117 - 117
1 Sep 2012
Gulhane S Meek D Patil S
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This case series highlights the use of the Ganz approach (trochanteric slide approach) and surgical dislocation for excision of fibrous dysplasia of the femoral neck, pigmented villonodular synovitis and synovial chondromatosis of the hip.

The first patient was a 16-year-old girl, who presented with pain in her hip, having fallen whilst playing football. Investigations revealed a fibrous dysplasia, which was successfully excised returning her to an active lifestyle.

The second patient was a 27-year-old lady, who presented having suffered left hip pain for four years. She was diagnosed with a pigmented villonodular synovitis, which was excised and the patient was able to return to the gym.

The third patient was a 41-year-old lady, who presented after experiencing right hip pain both at night and at rest for a year, without any trauma. She was diagnosed with synovial chondromatosis and returned to all activities of daily living.

The Ganz approach allows safe dislocation of the hip joint without the risk of osteonecrosis of the femoral head. We demonstrate that it is possible to obtain excellent exposure of the femoral neck, head and acetabulum to surgically treat these three tumours of the hip. The surgeon can thus be reassured that complete excision of the tumour has occurred.

This series can recommend the Ganz approach with trochanteric slide and full surgical dislocation of the hip to excise pigmented villonodular synovitis, synovial chondromatosis and fibrous dysplasia of the hip.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 35 - 35
1 Jun 2012
D'Lima D Wong J Patil S Flores-Hernandez C Colwell C Steklov N Kester M
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Introduction

Aligning the tibial tray is a critical step in total knee arthroplasty (TKA). Malalignment, (especially in varus) has been associated with failure and revision surgery. While the link between varus malalignment and failure has been attributed to increased medial compartmental loading and generation of shear stress, quantitative biomechanical evidence to directly support this mechanism is incomplete. We therefore constructed and validated a finite element model of knee arthroplasty to test the hypothesis that varus malalignment of the tibial tray would increase the risk of tray subsidence.

Methods


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVIII | Pages 38 - 38
1 Jun 2012
Gulhane S Hussain S Patil S
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This case series highlights the use of the Ganz approach and surgical dislocation for excision of fibrous dysplasia of the femoral neck, pigmented villonodular synovitis and synovial chrondromatosis of the hip, which has never been described for use with all three tumours together. These are rare benign tumours, which were found incidentally and required excision.

We demonstrate that it is possible to obtain excellent exposure of the femoral neck, head and acetabulum allowing easy inspection, exploration and debridement of these three tumours of the hip.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVIII | Pages 44 - 44
1 Jun 2012
Smith J Hussain S Horey L Patil S Meek R
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Hip resurfacing has generally been used in younger patients with early osteoarthritis of the hip. There has been considerable recent interest in this over the past few years. We conducted a prospective randomised trial comparing 2 hip resurfacing implants, Durom and ASR looking at radiological and clinical outcomes.

Forty-nine patients (78% male) with hip osteoarthritis which met the criteria for hip resurfacing were randomised to receive either a Durom or ASR resurfacing implant. These patients have so far been followed up for a minimum of one year. The groups were comparable in age (p=0.124) and gender (p=0.675). The average age in the ASR group was 54.04 years and in the Durom group it was 51.25.

Radiological views were scrutinised immediately post op and at final follow up so far to look at cup inclination, stem-shaft angle, and acetabular osseointegration.

Clinical outcomes were compared using the Oxford hip scores, WOMAC scores and SF12 scores.

At minimum follow up of 1 year the mean post operative Oxford hip score was not significantly different between the Durom (45.32, SD 3.93) and ASR (43.44, SD 8.44). The mean post operative WOMAC score was also not significantly different between the Durom (52.56, SD 6.06) and ASR (49.63, SD 2.23). There was no difference between the groups with regards to signs of osseointegration from radiological assessment (p=0.368). There were 3 periprosthetic femoral neck fractures (5.7%) and one revision for pain.

We conclude from this trial that there is no difference in the clinical or radiological findings between the Durom and ASR implants.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVIII | Pages 29 - 29
1 Jun 2012
Gulhane S Hussain S Patil S
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The outcome of periacetabular osteotomy in dysplastic hips is dependent on the absence of preoperative osteoarthritis [OA]. The purpose of this study was to analyze whether Tonnis grading is a reliable predictor of OA in patients with hip dysplasia.

Thirty patients were identified who had undergone hip arthroscopy surgery to assess their suitability for periacetabular osteotomy. Radiographs were assessed for anterior centre edge angle, lateral centre edge angle, Tonnis angle and Tonnis grade for OA changes. The radiographic grading of OA was compared with arthroscopic findings.

Results

The average age at the time of arthroscopy was 34.97 [16 – 53yrs] (28 females). Tonnis grade did not correlate with arthroscopic findings (p=0.082). There was a trend for patients with a higher Tonnis grade to have more OA changes. Of the 30 patients, all 3 with grade 0 were fit for periacetabular osteotomy, while only 8 out of 24 with grade I, and 1 out of 3 with grade II were fit for periacetabular osteotomy.

This study reports that even when radiographic grading showed minimal OA changes, arthroscopy findings indicated significant OA changes. Hence radiographic grading is a poor indicator of OA and other diagnostic modality should be sought before proceeding with joint preserving surgery in this highly selected subgroup of dysplastic hips.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVIII | Pages 31 - 31
1 Jun 2012
Hussain S Cairns D Mann C Horey L Patil S Meek R
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The objective was to compare vastus lateralis muscle splitting verses muscle sparing surgical approach to proximal femur for fixation of intertrochanteric fracture.

Of the 16 patients in this prospective randomised double blind study 8 were randomised to vastus lateralis muscle splitting and rest to muscle sparing group. Main outcome measurement was assessment of status of vastus lateralis muscle at 2 and 6 weeks using nerve conduction study. Preoperative demographics were identical for both the groups.

There was no statistically significant difference between the groups with regards to velocity, latency, and amplitude. The postoperative haemoglobin drop, heamatocrit, position of the dynamic hip screw and mobility status were identical.

Both clinical and neurophysiological outcome suggest that damage done to vastus lateralis either by splitting or elevating appears to be identical.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 36 - 36
1 Jun 2012
D'Lima D Colwell C Steklov N Patil S
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Background

While in vivo kinematics and forces in the knee have been studied extensively, these are typically measured during controlled activities conducted in an artificial laboratory environment and often do not reflect the natural day-to-day activities of typical patients. We have developed a novel algorithm that together with our electronic tibial component provide unsupervised simultaneous dynamic 3-D kinematics and forces in patients.

Methods

An inverse finite element approach was used to compute knee kinematics from in vivo measured knee forces. In vitro pilot testing indicated that the accuracy of the algorithm was acceptable for all degrees of freedom except knee flexion angle. We therefore mounted an electrogoniometer on a knee sleeve to monitor knee flexion while simultaneously recording knee forces. A finite element model was constructed for each subject. The femur was flexed using the measured knee flexion angle and brought into contact with the fixed tibial insert using the three-component contact force vector applied as boundary conditions to the femoral component, which was free to translate in all directions. The relative femorotibial adduction-abduction and axial rotation were varied using an optimization program (iSIGHT, Simulia, Providence, RI) to minimize the difference between the resultant moments output by the model and the experimentally measured moments. Maximum absolute error was less than 1 mm in anteroposterior and mediolateral translation and was 1.2° for axial rotation and varus-valgus angulation. This accuracy is comparable to that reported for fluoroscopically measured kinematics. We miniaturized the external hardware and developed a wearable data acquisition system to monitor knee forces and kinematics outside the laboratory.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XI | Pages 1 - 1
1 Apr 2012
Augustine A Horey L Murray H Craig D Meek R Patil S
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The diagnosis and treatment of hip disease in young adults has rapidly evolved over the past ten years. Despite the advancements of improved diagnostic skills and refinement of surgical techniques, the psychosocial impact hip disease has on the young adult has not yet been elucidated.

This observational study aimed to characterise the functional and psychosocial characteristics of a group of patients from our young hip clinic. 49 patients responded to a postal questionnaire which included the Oswestry Disability Index (ODI) and Hospital Anxiety and Depression Scale (HADS). Median age was 20 years (range 16-38) with a gender ratio of 2:1 (female: male). The most common diagnoses were Perthes' disease and developmental hip dysplasia. More than half of our patients had moderate to severe pain based on the Visual Analogue Scale (VAS) and at least a moderate disability based on the ODI. Thirty-two percent of patients were classified as having borderline to abnormal levels of depression and 49% of patients were classified as having borderline to abnormal levels of anxiety based on the HADS. Comparison of the ODI with the VAS and HADS anxiety and depression subscales showed a significant positive correlation (p<0.05). Multiple regression showed the ODI to be a significant predictor of the HADS anxiety and depression scores (regression coefficient 0.13, 95% confidence interval 0.06 to 0.21, p<0.05).

This study highlights the previously unrecognised psychosocial effects of hip disease in the young adult. A questionnaire which includes HADS may be of particular value in screening for depression and anxiety in young people with physical illness. This study also highlights that collaboration with psychologists and other health care providers may be required to achieve a multidisciplinary approach in managing these patients.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 107 - 107
1 Mar 2012
Patil S Gandhi J Curzon I Hui A
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Stable ankle fractures can be successfully treated non-operatively with a below knee plaster cast. In some European centres it is standard practice to administer thromboprophylaxis, in the form of low molecular weight heparin, to these patients in order to reduce the risk of deep venous thrombosis (DVT).

The aim of our study was to assess the incidence of DVT in such patients in the absence of any thromboprophylaxis. We designed a prospective study, which was approved by the local ethics committee. We included 100 consecutive patients with ankle fractures treated in a below knee plaster cast. At the time of plaster removal (6 weeks), patients were examined for signs of DVT. A colour doppler duplex ultrasound scan was then performed by one of the two experienced musculoskeletal ultrasound technicians.

We found that 5 patients developed a DVT. Two of these were above knee, involving the superficial femoral vein and popliteal vein respectively. The other three were below knee. None of the patients had any clinical symptoms or signs of DVT. None of the patients developed pulmonary embolism. Of these five patients, four had some predisposing factors for DVT.

The annual incidence of DVT in the normal population is about 0.1%. This can increase to about 4.5% by the age of 75. DVT following hip and knee replacement can occur in 40-80% of cases. Routine thromboprophylaxis may be justified in these patients. However, with a low incidence of 5% following ankle fractures treated in a cast, we believe that routine thromboprophylaxis is not justified.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_III | Pages 24 - 24
1 Feb 2012
Patil S Greidanus N Garbuz D Masri B Duncan C
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Introduction

Despite advances in surgical technique and prosthetics there continues to be a number of patients who are dissatisfied with the results of their knee replacement procedure. The outcome after total knee arthroplasty (TKA) has been reported frequently with use of condition-specific measures, but patient satisfaction has not been well studied.

Material and methods

160 patients who received primary total knee arthroplasty (TKA) were evaluated prospectively to evaluate factors that may be associated with patient satisfaction. At minimum one year follow-up all patients were evaluated and completed validated self-report satisfaction questionnaires. Patient, surgeon, implant and process of care variables were assessed along with WOMAC, Oxford Knee and SF-12 scores. Univariate and multivariate analyses were performed to assess for independent factors associated with post-operative satisfaction.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_III | Pages 40 - 40
1 Feb 2012
Patil S Montgomery R
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We reviewed 78 femoral and tibial non-unions treated between January 1992 and December 2003. Of these, we classified 41 as complex non-unions, because of infection (22), bone loss or prior failed surgery to produce union. These were treated with Ilizarov frames. 39 of the 41 nonunions healed successfully at a median time of 11 months.

Using the ASAMI scoring system, we had 17 excellent, 14 good, 4 fair and 6 poor bone results. The functional results were excellent in 14, good in 14, fair in 2 and poor in 2. All but 2 patients were extremely satisfied with the results. The average cost of treatment to the treating hospital was approximately £30,000 per patient. In comparison the cost for a patient with a below-knee amputation was £999 per year. This would amount to a cost of £36,000 per patient in their lifetime.

There is therefore not a great difference between the cost of limb salvage and amputation. The difference that exists favours limb salvage, if patient selection can accurately predict the salvage of a useful limb. Early referral to tertiary centres would reduce the morbidity and the prolonged time off work. The results justify the expense but the NHS needs to make financial provision for reconstruction of complex nonunions.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 414 - 414
1 Nov 2011
Nagamine R D’Lima D Patil S Chen W Kondo K Todo M Hara T Sugioka Y
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Routinely in TKA, at least one of the cruciate ligaments are sacrificed. The cruciate ligaments excision may have an impact in the stability of the reconstructed knee by virtue of the impact on the gap kinematics. In this study, a selective cutting protocol was designed to quantify the individual contribution of ACL and PCL about the knee by means of a loaded cadaveric model.

Five fresh frozen normal cadaver specimens were used. The femur was fixed to a specially designed machine, and 3D tibial movements relative to the femur and joint gap distances were measured by means of a navigation system from full extension to 140° flexion. The joint was distracted with 10 pounds. The measurement was performed before and after ACL and PCL excision.

Medial gap distance at 90° flexion before and after cruciate ligaments excision was 4.3 ± 2.7 mm (mean ± SD) and 5.1 ± 2.8 mm (p< 0.05) respectively. Cruciate ligaments excision significantly widened the medial and lateral gaps at many flexion angles, and the effect of excision on the gap distance was different between medial and lateral sides especially at 90° knee flexion. Cruciate ligaments excision also significantly influenced knee kinematics. If this varying gap is not accounted for either through implant shape and orientation or through soft tissue adjustments, instability could be the result.

Surgeons should be made aware of the influence of cruciate excision on varus/valgus laxity throughout the range of motion. Design modification of the femoral component may also be necessary in order to obtain optimal stability in deep flexion.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 405 - 405
1 Nov 2011
Colwell C Steklov N Patil S D’Lima D
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Total knee arthroplasty (TKA) provides relatively pain-free function for patients with end-stage arthritis. However, return to recreational and athletic activities is often restricted based on the potential for long-term wear and damage to the prosthetic components. Advice regarding safe and unsafe activities is typically based on the individual surgeon’s subjective bias. We measured knee forces in vivo during downhill skiing to develop a more scientific rationale for advice on post-TKA activities A TKA patient with the tibial tray instrumented to measure tibial forces was studied at two years postoperatively. Tibial forces were measured for the various phases of downhill skiing on slopes ranging in difficulty from green to black.

Walking on skis to get to the ski lift generated peak forces of 2.1 ± 0.20 xBW (times body weight), cruising on gentle slopes 1.5 ± 0.22 xBW, skating on a flat slope 3.9 ± 0.50 xBW, snowplowing 1.7 ± 0.20 xBW, and coming to a stop 3 ± 0.12 xBW. Carving on steeper slopes generated substantially higher forces: blue slopes (range 6° to 10°), 4.4 ± 0.18 xBW; black slopes (range 15° to 20°), 4.9 ± 0.57 xBW. These forces were compared to peak forces generated by the same patient during level walking: 2.6 ± 0.4 xBW, stationary biking 1.3 ± 0.7 xBW, stair climbing 3.1 ± 0.31 xBW, and jogging 4.3 ± 0.8 xBW.

The forces generated on the knee during recreational skiing vary with activity and level of difficulty. Snow-plowing and cruising on gentle slopes generated lower forces than level walking (comparable to stationary biking). Stopping and skating generated forces comparable to stair climbing. Carving on steeper slopes (blues and blacks) generated forces as high as those seen during jogging. This study provides quantitative results to assist the surgeon in advising the patient regarding postoperative exercise.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 8 | Pages 1033 - 1044
1 Aug 2011
Periasamy K Watson WS Mohammed A Murray H Walker B Patil S Meek RMD

The ideal acetabular component is characterised by reliable, long-term fixation with physiological loading of bone and a low rate of wear. Trabecular metal is a porous construct of tantalum which promotes bony ingrowth, has a modulus of elasticity similar to that of cancellous bone, and should be an excellent material for fixation.

Between 2004 and 2006, 55 patients were randomised to receive either a cemented polyethylene or a monobloc trabecular metal acetabular component with a polyethylene articular surface. We measured the peri-prosthetic bone density around the acetabular components for up to two years using dual-energy x-ray absorptiometry.

We found evidence that the cemented acetabular component loaded the acetabular bone centromedially whereas the trabecular metal monobloc loaded the lateral rim and behaved like a hemispherical rigid metal component with regard to loading of the acetabular bone. We suspect that this was due to the peripheral titanium rim used for the mechanism of insertion.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 313 - 314
1 Jul 2011
Ahmad M Bajwa A Patil S Bhattacharya R Nanda R Danjoux G Hui A
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Introduction: To quantify the magnitude and incidence of haemodynamic changes that occurs during the fixation of extracapsular proximal femoral fractures when using either intra-medullary or extra-medullary fixation device.

Methods: A prospective group of 31 patients with extra-capsular proximal femoral fractures were randomised to either fixation using an extra-medullary compression hip screw or an intra-medullary hip screw. All patients received a general anaesthetic adhering to a standardised anaesthetic protocol including invasive blood pressure monitoring and arterial blood gas sampling. Trans-oesophageal Doppler probe and monitor was used to record pre-operative hypovolaemia and peri-operative changes in cardiac output, stroke volume and corrected flow time (FTc – a reflection of left ventricular end diastolic pressure) during placement of implants.

Results: 77% of patients were hypovolaemic preoperatively, which was corrected with an average of 439 mls of colloid replacement fluid. Application of the extra-medullary CHS produced no change in haemodynamic function. However on insertion of the IMHS we found a statistically significant reduction in stroke volume, cardiac output and FTc without changes in pulse rate or mean arterial pressure. The changes were transient with normal cardiac function returning by 5 mins post operatively.

Conclusion: The transient fall in cardiac function during insertion of the intramedullary hip screw may be caused by fat embolism entering the venous circulation. As these changes are not detected with standard non-invasive monitoring we would recommend that intramedullary devices be used with caution in elderly patients who tend to have poor physiological reserve.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 181 - 182
1 May 2011
D’lima D Kester M Wong J Steklov N Patil S Colwell C
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Introduction: Aligning the tibial tray is a critical step in total knee arthroplasty (TKA). Malalignment, (especially in varus) has been associated with failure and revision surgery. While the link between varus malalignment and failure has been attributed to increased medial compartmental loading and generation of shear stress, quantitative biomechanical evidence to directly support this mechanism is incomplete. We therefore constructed a finite element model of knee arthroplasty to test the hypothesis that varus malalignment of the tibial tray would increase the risk of tray subsidence.

Methods: Cadaver Testing: Fresh human knees (N = 4) were CT scanned and implanted with a TKA cruciate-retaining tibial tray (Triathlon CR. Stryker Orthopaedics). The specimens were subjected to ISO-recommended knee wear simulation loading for up to 100,000 cycles. Micromotion sensors were mounted between the tray and underlying bone to measure micromotion. In two of the specimens, the application of vertical load was shifted medially to generate a load distribution ratio of 55:45 (medial: lateral) to represent neutral varus-valgus alignment. In the remaining two specimens, a load distribution ratio of 75:25 was generated to represent varus alignment.

Finite element analysis: qCT scans of the tested knees were segmented using MIMICS (Materialise, Belgium). Material properties of bone were spatially assigned after converting bone density to elastic modulus. A finite element model of the tibia implanted with a tibial tray was constructed (Abaqus 6.8, Simulia, Dassault Systèmes). Boundary conditions were applied to simulate experimental mounting conditions and the tray was subjected to a single load cycle representing that applied during cadaver loading.

Results: The two cadaver specimens tested at 55:45 medial:lateral (M:L) force distribution survived the 100,000 cycle test, while both cadaver specimens tested at 75:25 M:L force distribution failed. The finite element model generated distinct differences in compressive strain distribution patterns in the proximal tibia. A threshold of 2000 microstrain was used for fatigue damage in bone under cyclic loading. Both specimens loaded under 75:25 M:L distribution demonstrated substantially larger cortical bone volumes in the proximal tibial cortex that were greater than this fatigue threshold.

Discussion and Conclusion: We validated a finite element model of tibial loading after TKA. Local compressive strains directly correlated with subsidence and failure in cadaver testing. A significantly greater volume of proximal tibial cortical bone was compressed to a strain greater than the fatigue threshold in the varus alignment group, indicating an increased risk for fatigue damage. This model is extremely valuable in studying the effect of surgical alignment, loading, and activity on damage to proximal bone.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 62 - 62
1 Jan 2011
Augustine A Macdonald D Murray H Badesha J Mohammed A Meek R Patil S
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Infection following hip arthroplasty although uncommon can have devastating outcomes. Obesity, defined as a BMI of ≥ 30, is a risk factor for infection in this population. Coagulase negative staphylococcus aureus (CNS) is the commonest causative organism isolated from infected arthroplasties. This study was performed to determine if there has been a change in the causative organisms isolated from infected hip arthroplasties and to see if there is a difference in obese patients.

Data on all deep infection following primary and revision hips was obtained from the surgical site infection register from April 1998 to Nov 2007. Case notes were reviewed retrospectively. There were 49 patients with 51 infected arthroplasties; 25 infected Primary THAs and 26 infected Revision THAs. We found a female preponderance in the infected primary and revision THAs (n=30). 63.2% of all patients had a BMI of ≥ 30, compared to only 34.7% of the non infected population (p< 0.0001). Over the period studied, CNS was the most common organism isolated (56.8%) followed by mixed organisms (37.2%) and staphylococcus aureus (25.4%). Multiple organisms were found exclusively in obese patients. In more than half of cases the causative organisms were resistant to more than two antibiotics.

This study shows that over the last 10 years, CNS continues to be the most frequently isolated organism in infected hip arthroplasties. Multiple organisms with multiple antibiotic resistances are common in obese patients. On this basis we recommend that combination antibiotic therapy should be considered in obese patients.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 545 - 545
1 Oct 2010
Cairns D Mallik A Mann C Meek D Patil S Reece A
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Introduction: Current Literature is sparse with respect to the optimum surgical approach for fixation of a fractured neck of Femur. A cadaveric study has been performed to determine the pattern of innervation of the Vastus Lateralis muscle. Results indicate that a muscle splitting technique may cause more nerve damage than a muscle reflection technique. The purpose of this study was to determine the clinical and neurophysiological effects of two different surgical approaches to the proximal femur.

Methods: Patients were randomised to receive either a Vastus splitting approach or a Vastus reflecting approach to the fractured femoral neck. The contralateral leg was used as the control for neurophysiological investigation. Needle electromyography was performed on both the operated and unoperated limbs within 2 weeks of surgery.

Results: 25 patients were included in the study randomisation. A total of 17 patients completed neurophysiological investigation, 8 in muscle reflection and 9 in muscle splitting groups. There was a significant reduction in femoral nerve conduction velocity compared to the unoperated control side in the muscle split group. This was also the case for amplitude of response measured in the Vastus muscle. The muscle reflection group showed no significant differences in these parameters compared to the unoperated side.

Conclusion: On the basis of the results of this study we recommend a Vastus Lateralis reflecting approach for proximal Femoral fracture fixation. The functional outcome of a muscle splitting approach remains unclear but could be investigated as part of a larger trial.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 387 - 388
1 Jul 2010
Augustine A Macdonald D Murray HM Mohammed A Meek R Patil S
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Introduction: Infection following hip arthroplasty although uncommon can have devastating outcomes. Obesity, defined as a BMI of ≥ 30, is a known risk factor for infection in this population. Coagulase negative Staph Aureus (CNS) is the commonest causative organism isolated from infected arthroplasties. This study was performed to determine if there has been a change in the causative organisms isolated from infected hip arthroplasties and to see if there is a difference in obese patients.

Methods: Data on all deep infection following primary and revision hips was obtained from the surgical site infection register from April 1998 to November 2007. All case notes were reviewed retrospectively.

Results: There were 49 patients with 51 infected arthroplasties; 25 infected Primary THAs and 26 infected Revision THAs. We found a female preponderance in the infected primary and revision THAs (n=30). 65.3% of all patients had a BMI of ≥ 30. Over the period studied, Coagulase negative Staph was the most common organism isolated (56.8%) followed by mixed organisms (37.2%) and Staph Aureus (25.4%). Multiple organisms were found exclusively in obese patients. In more than half of cases the causative organisms were resistant to ≥ 2 antibiotics.

Discussion: This study shows that over the last 10 years, CNS continues to be the most frequently isolated organism in infected hip arthroplasties. Multiple organisms with multiple antibiotic resistances are common in obese patients. On this basis we recommend that combination antibiotic therapy should be considered in obese patients.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 395 - 395
1 Jul 2010
Periasamy K Spencer S Patil S Mohammed A Murray H Watson W Meek R
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Introduction: The ideal acetabular component has low wear, permanent fixation and physiological bone loading. Recently trabecular metal has been promoted as reproducing the modulus of trabecular bone with a cementless fixation. The aim of this trial was to see if a monobloc trabecular backed polyethylene acetabular component loaded the pelvis physiologically as a cemented polyethylene component.

Method: Between 2004 and 2006 54 patients were ran-domised to a cemented polyethylene acetabular component versus a monobloc trabecular backed polyethylene acetabular component. The primary outcome measurement was bone density in peri-prosthetic acetabular regions of interest measured preoperatively and post operatively at 6 weeks and 1 year. Secondary outcomes measured were radiographic and functional outcomes (HHS and Oxford score).

Results: Radiographically 8 patients in the trabecular group had a significant gap in zone II which resolved in 6 by 1 year. The cemented group had 3 patients with a radiolucent line (zone 1) at 1 year. HHS and OXFORD scores improved with no significant difference between the groups. Both groups had significant loss of bone density in the ilium and ischium. The trabecular group produced a significant increase in bone density in the superolateral region. The cemented group produced increased bone density in the superomedial region.

Discussions and Conclusions: There is a significant reduction in BMD for both groups in the upper pelvis and ischium in keeping with finite element modelling predictions. The press-fit group relative to the cemented group resulted in decreased BMD in the superomedial peri-prosthetic region. The trabecular monobloc cup therefore behaves more like a rigid cementless shell despite the properties of trabecular metal.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 242 - 242
1 Mar 2010
Auyeung J Patil S Gower A
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Introduction: Tutobone is a solvent-preserved cancellous bovine bone substitute. There is little published about its use in humans. We have been using it as a wedge graft to correct deformity in hindfoot fusion surgery.

Aim: To review the outcome following the use of Tutobone in hindfoot fusion and compare it with a control group without Tutobone.

Method: We performed a retrospective review of all hindfoot fusion performed by the senior author (AG) from 1 Sep 2004 to 31 Jan 2008. We excluded all revision procedures for non-union or malunion. A CT or MRI scan was performed to assess union and graft incorporation in the Tutobone patients at more than six months postoperatively. In the control group fusion was assessed with plain radiographs. The difference in proportion of fusion with complete fusion by six months post-operatively was assessed with a Fisher’s exact test

Results: There were eleven patients in the Tutobone group (1 ankle, 7 subtalar and 3 triple fusions) and 35 in the control group (15 ankle, 11 subtalar, 3 pantalar and 6 triple fusions). All Tutobone patients had partial union on CT/MRI scans. The Tutobone graft had not incorporated at a mean time interval of 14 months post surgery. 30 out of 35 control patients had fused by six months and 33 out of 35 controls were fused by 12 months. The rate of complete fusion between the two groups at six months was statistically significant (p< 0.0001). Two Tutobone patients developed an inflammatory reaction at more than six months post fusion. This reaction is not infective and appears to be a reaction to the Tutobone.

Conclusion: Tutobone should not be used in hindfoot fusion surgery.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 414 - 415
1 Sep 2009
Patil S White L Jones A Dixon J Hui A
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Idiopathic anterior knee pain (AKP) is common in adolescents and young adults. Most believe that the origin of the problem lies in the patello-femoral joint. Hamstring tightness has also been attributed as an important cause.

The aim of our study was to compare biometric parameters in patients with idiopathic AKP and controls. We also wanted to assess whether there was a difference in the relative electromyographic (EMG) onset times of the medial and lateral hamstrings.

We prospectively recruited patients with idiopathic anterior knee pain in the age group 11 to 25. Patients, but not the control population, had AP, lateral and skyline radiographs taken to rule out other pathology.

We had 34 patients (60 knees) with a minimum one year follow up. There was no difference in the symptoms of patients who attended physiotherapy as compared to those who did not. Patients with knee pain had significantly more hip external rotation (63 deg) as compared to the control (47 deg) group (p=0.001). Patients also had significantly more hamstring tightness (p=0.04).

Surface EMG was recorded (17 patients and controls each) from the medial and lateral hamstrings during 3 repetitions of a maximal voluntary isometric contraction exercise with the knee at 45° of flexion. The lateral hamstrings contracted 48.7 m.sec earlier than the medial hamstrings in patients as compared to controls.

AKP is a multifactorial and self-limiting disorder. Earlier contraction of the lateral hamstrings may cause tibial external rotation and contribute to the symptoms. Our data suggests that physiotherapy did not significantly alter the course of the condition. We believe that increased hip external rotation may contribute to the symptoms by increasing medial facet stress.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 116 - 116
1 Mar 2009
Patil S Hui A
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Introduction: Several institutes in continental Europe and the US now prescribe low molecular weight heparin for patients with ankle fractures being treated in a below knee plaster cast. Jorgensen et al reported an incidence of deep venous thrombosis (DVT) of up to 20% in patients treated in a cast. However, their study included patients with variable diagnoses, ranging from tendon ruptures to fractures. The aim of our study was to assess the incidence of DVT in patients with ankle fractures that have been treated conservatively in a below knee cast.

Method: We performed an ultrasound scan on patients with conservatively ankle fractures at the time of removal of the cast. The same ultrasound technician performed all the scans. The local regional ethics committee had approved this study.

Results: So far we have performed an ultrasound scan on 98 patients with ankle fractures. We are likely to complete the study in November 2006 (120 patients). We have encountered only 2 below knee DVTs (2.04 %). None of them involved the popliteal vein. Both patients were completely asymptomatic and were full weight bearing in the cast. A repeat scan showed no evidence of progression. None of the patients had an above knee DVT or a pulmonary embolism.

Discussion: The risk of deep venous thrombosis is said to be higher in patients with a plaster cast because of the decreased ability of the calf muscles to pump the venous blood back to the heart. Though some studies have indicated an incidence of up to 20%, the incidence in our population was only about 2%Thus, DVT is a rare event in patients with ankle fractures. Though it is a serious event, its rarity does not justify a blanket prophylaxis regimen for all patients with ankle fractures.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 547 - 547
1 Aug 2008
Patil S Mohammed A Meek R
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Introduction: Removal of well-fixed, cementless, acetabular components after resurfacing hip arthroplasty remains a challenging problem. Damage to host bone may limit options for reconstruction, compromise the long-term result of the revision operation and fundamentally defeat the aim of bone conserving resurfacing hip surgery.

Methods: A series of 6 consecutive patients who under-went removal of a secure, acetabular resurfacing component at the time of revision arthroplasty were included for review. During the operative procedure, the size of the component which was removed and the diameter of the final reamer used prior to implantation and final acetabular implant were recorded. The modification of the standard explant technique will be described which allows safe removal of any size of acetabular component.

Results: In all patients the indication for index arthroplasty was osteoarthritis. Three cases were MMT (Smith and Nephew), 2 Cormet 2000 (Corin, UK). and 1 DUROM (Zimmer). The indications for acetabular revision were infection in all cases. The median difference between the size of component removed and the size of final component implanted was 4 mm.

Discussion: Our modification uses a pre-existing system. The ease of removal with this modification and the lack of any further damage to the host bone illustrates that the Explant Acetabular Cup Removal System can be safely expanded to removal of well fixed resurfacing monoblock acetabular components. With experience, any manufacturers resurfacing shell can be removed with virtually no bone loss.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 321 - 321
1 Jul 2008
Patil S Kumar V Kamath V White L Dixon J Hui A
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Introduction: Poor proprioception and imbalance between quadriceps and hamstrings have been suggested as causes for anterior knee pain. The aim of our study was to compare the proprioception of patients with anterior knee pain to a normal population and to compare the activity of quadriceps and hamstrings using electromyography (EMG) in the 2 groups.

Methods: Patients and controls between the ages 11–25 yrs were recruited into the study. The proprioception (stability index) of the patients and controls was tested using the Biodex stability system. This computerised system tests the ability of a person to balance his/her own body on a platform that moves in various directions. Surface EMG was recorded from the quadriceps and hamstrings during this test. EMG was also recorded as the patients and controls stepped onto a 20cm step. EMG activity was normalised to levels elicited during maximal isometric contractions.

Results: 18 patients and 27 controls were recruited.

We found no significant difference between the groups in the EMG intensity of vastus lateralis relative to biceps femoris, or vastus medialis relative to vastus lateralis, during the balance test or during the step up task (Mann Whitney U test all p> 0.05). We did not find any difference in the proprioceptive abilities of the two groups

Conclusion: We found no significant difference between the groups in the intensity of muscle contraction of the hamstrings relative to the quadriceps, i.e. no evidence for an imbalance in the patients. However the temporal relation between the two needs further investigation.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 327 - 327
1 Jul 2008
Hanusch BC Patil S Hui A Gregg P
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The aim of this study was to determine whether there is a difference in the functional outcome between fixed and mobile bearings in total knee arthroplasty.

120 patients were randomized (computer generated) to receive either a fixed or mobile bearing P.F.C. Sigma total knee replacement. 96 patients were needed to detect a 20° difference in range of motion (ROM) with a significance level of 0.05 and a test power of 0.97. Oxford knee score (OKS) and ROM were assessed independently before and one year after surgery.

Mean ROM and Oxford knee score before and at one year after surgery for both groups are shown as preliminary results for 70 patients (follow-up expected to be completed by March 2006):

There is no statistically significant difference in the mean ROM at one year and in change in ROM between the two groups (p=0.53 and p=0.21 respectively). The findings were similar for Oxford Knee Score at one year and change in Oxford Knee Score (p=0.45 and p=0.82). There was no early aseptic loosening in either group.

The one year results suggest that there is no significant difference in functional outcome measured as ROM and Oxford Knee Score between the two types of bearing. Further follow-up will be carried out to detect any differences in the long term outcome.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 323 - 323
1 Jul 2008
Patil S Mahon A McMurtry I Green S Port A
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Introduction: There is a recent trend of using a raft of small diameter 3.5 mm cortical screws instead of the large diameter 6.5mm screws in depressed tibial plateau fractures. Our aim was to compare the biomechanical properties of these two constructs in the normal and osteoporotic synthetic bone model.

Methods: 20 rigid polyurethane foam blocks with a density simulating osteoporotic bone and normal bone were obtained. A Schatzker type 3 fracture was created in each block. The fracture fragments were then elevated and supported using 2, 6.5mm cancellous screws or 4, 3.5mm cortical screws.

The fractures were loaded using a Lloyd’s machine and a load displacement curve was plotted.

Results: Osteoporotic model. The mean force needed to produce a depression of 5mm was 700.8N with the 4-screw construct and 512.4N with the 2 screw construct (p=0.007).

Non-osteoporotic model. The mean force requires to produce the same depression was 1878.2N with the 2-screw construct and 1938.2N with the 4 screw construct (p=0.42).

An increased fragmentation of the synthetic bone fragments was noticed with the 2-screw construct but not with the 4-screw construct.

Conclusion: A raft of 4, 3.5 mm cortical screws is biomechanically stronger than two, 6.5mm cancellous screws in resisting axial compression in osteoporotic bone.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 362 - 362
1 Jul 2008
Patil S Mahon A Green S Mcmurtry I Port A
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Introduction and aims: There is a recent trend of using a raft of small diameter 3.5 mm cortical screws instead of the large diameter 6.5mm screws in depressed tibial plateau fractures (Schatzker type 3). Our aim was to compare the biomechanical properties of these two constructs in the normal and osteoporotic sawbone model.

Methods: 10 sawbone (solid rigid polyurethane foam) blocks with a density simulating that of an osteoporotic bone and 10 blocks of a density simulating normal bone were obtained. A Schatzker type 3 fracture was created in each block. The fracture fragments were then elevated and supported using 2, 6.5mm cancellous screws in 10 blocks and 4, 3.5mm cortical screws in the remaining.

The models were loaded to failure using a Lloyd’s machine. A displacement (depression) of 5mm was taken to be the point of failure. A load displacement curve was plotted using Nexygen software and the force needed to cause a depression of 5mm was calculated in each block. Mann Whitney U test was used for statistical analysis.

Results: Osteoporotic model

The mean force needed to produce a depression of 5mm was 700.8N with the 4-screw construct and 512.4N with the 2 screw construct. This difference was statistically significant (p=0.007).

Non-osteoporotic model

The mean force requires to produce the same depression was 1878.2N with the 2-screw construct and 1938.2N with the 4 screw construct. The difference was not statistically significant (p=0.42).

An increased fragmentation of the sawbone fragments was noticed with the 2-screw construct but not with the 4-screw construct.

Conclusion: A raft of 4, 3.5 mm cortical screws is biomechanically stronger than 2, 6.5mm cancellous screws in resisting axial compression in osteoporotic bone.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 330 - 330
1 Jul 2008
Martin DJ Patil S Byrne D Leach WJ
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Aim: We have carried out a prospective study to compare duplex ultrasonography and transcutaneous oxygen tension as predictors of wound healing after knee arthroplasty.

Methods and Materials: 53 patients were included in the study. All underwent pre-operative duplex scans of their lower limbs. In addition, transcutaneous oxygen tension measurements were made adjacent to the proposed incision pre-operatively and on days 1, 3 and 7 post knee arthroplasty. Wound healing was assessed using the ASEPSIS wound score.

Results: 4 wounds had evidence of delayed wound healing. Duplex ultrasonography was a poor predictor of such problems; however there was a significant correlation between pre-operative transcutaneous oxygen tension and post-operative wound scores.

Conclusion: Pre-operative transcutaneous oxygen tension measurement is a better predictor of wound healing after knee replacement surgery than duplex ultrasonograph, and may be a useful adjunct to the investigation of patients at risk of wound problems post knee arthroplasty.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 21 - 21
1 Mar 2008
Patil S Sherlock D
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Femoral head deformity with flattening and lateral protrusion can occur secondary to epiphyseal dysplasia or avascular necrosis of any aetiology in childhood. This causes painful impingement of the lateral femoral head on the acetabular lip, a phenomenon known as hinge abduction. We aimed to review our experience of valgus extension osteotomy in the treatment of hinge abduction in children and young adults with avascular necrosis.

Twenty patients undergoing valgus osteotomy for hinge abduction performed by a single specialist were clinically and radiologically reviewed. The aetiology was Perthes disease in 16 patients and treatment of DDH in 4 patients. The indication for the procedure was pain and limited abduction. The mean follow-up was 4.5 years. Patients were assessed using modified Iowa hip scores at final follow-up. The procedure corrected some leg shortening and improved the abduction range of the affected hip. Overall 80 % of patients did well. The mean Iowa hip score in Perthes group was 84 at final follow-up.

Four patients preoperatively had cysts/ defects in their femoral head. These were seen to fill up during their postoperative follow-up. Poorer outcome was associated with preoperative hip stiffness and surgery before stabilisation of the avascular process.

Conclusion: Valgus osteotomy is an effective procedure for relieving hinge abduction with associated additional benefits including improvement of leg shortening and improvement in hip abduction. The procedure should be avoided in stiff hips.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 137 - 137
1 Mar 2008
Patil S Port A Green S
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Purpose: To biomechanically compare the stability provided by 2, 6.5mm cancellous screws versus that provided by 4, 3.5mm cortical screws in depressed tibial plateau fractures

Methods: We obtained 20 sawbone(solid polyurethane foam) blocks of dimensions 9x6.5x3.5cm. 10 of these blocks had a density of normal cancellous bone (20pcf) and 10 represented osteoporotic bone (10pcf). We created a depressed fracture(Schatzker type 3) using a coring saw. Each fracture had 4 depressed fragments, which were elevated and supported using either 2,6.5mm cancellous screws or 4, 3.5mm cortical screws. The fractures were loaded axially using the Lloyds materials testing machine. A force displacement curve was plotted. A depression of 5mm was considered to be failure.

Results: Osteoporotic model|The mean force needed to produce a depression of 5mm was 700.8N with the 4-screw construct and 512.4N with the 2 screw construct. This difference was significantly significant (p=0.007). |Non-osteoporotic model|The mean force requires to produce the same depression was 1878.2N with the 2-screw construct and 1938.2N with the 4 screw construct. The difference was not statistically significant (p=0.42).

Conclusions: A raft of 4, 3.5 mm cortical screws was biomechanically stronger than 2, 6.5mm cancellous screws in resisting axial compression in the osteoporotic bone model. There was no significant difference in the 2 constructs in non-osteoporotic bone model.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 140 - 140
1 Mar 2008
Patil S Ramakrishnan M Stothard J
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Purpose: To compare the analgesia provided by pure subcutaneous infiltration (Gale technique) of lignocaine with that provided by infiltration of lignocaine into the carpal tunnel in addition to the subcutaneous tissue (Altissimi technique) for carpal tunnel decompression

Methods: 20 patients with bilateral carpal tunnel syndromes were chosen for the study. Patients were randomised to receive one local anaesthetic technique on one side and the other on the other side. The pain scores were recorded intraoperatively and 2 and 4 hours postoperatively.

Results: 5 patients experienced intra-operative pain with the Gale technique, while one did with the Altissimi technique (p=0.15 using Mann Whitney U test). Postoperative analgesia at 2 hours was significantly better with the Altissimi technique (p= 0.009). Patients with the Altissimi technique also required less number of analgesic tablets over 24 hours post surgery (p=0.01).

Conclusions: We found no statistically significant difference in the intra-operative pain scores with the two techniques. However, postoperative pain relief was much better with the Altissimi technique.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 162 - 162
1 Mar 2008
D’Lima DD Patil S Steklov N Colwell CW
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Complications after total knee arthroplasty (TKR) such as malalignment, instability, subluxation, excessive wear, and loosening have been attributed to poor soft-tissue balance. Traditional approaches for soft-tissue balance involve static measurements in full extension and at 90° flexion. A trial prosthesis instrumented with force transducers was used to measure soft-tissue balance through the entire range of flexion.

The trial prosthesis was instrumented with four force transducers, one at each corner of the tibial tray, and was implanted in four cadaver knees and four patients intra-operatively. Tibial forces were recorded during passive knee flexion after the tibial and femoral bone cuts were made and again after soft-tissue balance was achieved using standard techniques.

In all eight knees measurable imbalance was initially recorded. The differences in forces were a mean of 18 N (range, 6 to 72) mediolateral and a mean of 26 N (range, 13 to 108) anteroposterior. After a routine procedure of soft-tissue balancing, the mean imbalance between the transducers was reduced by 62 % to 87 % (p < 0.05). However, even the knees that appeared perfectly balanced at 0° and 90° flexion, some imbalance occurred [mean 22 N (range, 2 to 34)] at flexion angles other than 0° and 90°.

Soft-tissue balance in TKR remains a complex concept. Even after accurate static balancing was achieved in extension and 90° flexion, dynamic measurements revealed discrepancies in mid flexion, which may explain the wide variation in knee kinematics reported after TKR and in the reported incidences of mid-flexion knee instability. Computer-aided surgical navigation systems can increase the precision and accuracy of component alignment. However, these systems cannot directly address soft-tissue balance and knee tightness. An instrumented tibial prosthesis could be a useful adjunct to enhance the value of these navigation tools.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 162 - 163
1 Mar 2008
D’Lima DD Patil S Steklov N Slamin J Colwell C
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The knee is a complex joint that is difficult to model accurately. Although significant advances have been made in mathematical modeling, these have yet to be validated successfully in vivo. Direct measurement of knee forces should lead to a better understanding of the stresses seen in total knee arthroplasty. An instrumented knee prosthesis was developed to measure forces in vivo after total knee arthroplasty.

An instrumented tibial prosthesis was implanted in an 80-year-old male weighing 66 kg. The prosthesis measured forces at the four corners of the tibial tray. The patient walked approximately 1.6million steps per year before surgery (ankle accelerometer measurements). Knee forces were measured postoperatively during passive and active knee flexion, rehabilitation, rising from a chair, standing, walking, and climbing stairs.

The patient was walking with the help of a walker by postoperative day 3. Peak tibial forces were 1.2 times body weight (BW). By the sixth postoperative day the tibial forces during gait were 1.7 times BW. At six weeks the peak tibial forces during walking had risen to 2.4time BW. Stair climbing increased from 1.9 times BW on day 6 to 3.3 times BW at six weeks.

This represents the first direct in vivo measurement of tibial forces. In vivo tibiofemoral force data will be used to develop better biomechanical knee models and in vitro wear tests and will be used to evaluate the effect of improvements in implant design and bearing surfaces, rehabilitation protocols, and orthotics. This should lead to refining surgical techniques and to enhancing prosthetic designs that will improve function, quality of life, and longevity of total knee arthroplasty. This information is vital given the current trend in the increase of older population groups that are at higher risk for chronic musculoskeletal disorders.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 148 - 148
1 Mar 2008
Bourque J Patil S Masri B
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Purpose: There is little information in the literature regarding outcomes of unicompartmental knee arthroplasty (UKA) in patients receiving worker’s compensation (WC). The purpose of the present study is to compare the outcomes of UKA in patients receiving WC compared to patients without WC.

Methods: Nineteen patients with a WC claim treated by UKA for medial compartment arthritis were compared to twenty patients who underwent similar procedure but had no WC claim. Average follow up period was 37 months (range 30–60 months). Outcomes were evaluated using Knee Society Score (KSS) data. T test was used for statistical analysis. Comparisons were also made with respect to conversion in to total knee arthroplasty (TKA).

Results: WC patients improved from a mean preoperative KSS of 47.4 (range 30–70) to 76.9 (range 55–99), while non-WC patients improved from 43.3 (range 35–63) to 90.7 (range 74–100). The difference in improvement between the two groups was statistically significant (p=0.004). Furthermore, the postoperative KSS in the non-WC patients was significantly higher than that of the WC group (p=0.007). There was no significant difference between the incidences of conversion to TKA between the two groups.

Conclusions: These findings suggest that patients with WC claims have poorer outcomes after UKA in comparison to non-WC patients.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 10 | Pages 1340 - 1343
1 Oct 2007
Patil S Gandhi J Curzon I Hui ACW

Stable fractures of the ankle can be successfully treated non-operatively by a below-knee plaster cast. In some centres, patients with this injury are routinely administered low-molecular-weight heparin, to reduce the risk of deep-vein thrombosis (DVT). We have assessed the incidence of DVT in 100 patients in the absence of any thromboprophylaxis. A colour Doppler duplex ultrasound scan was done at the time of the removal of the cast.

Five patients did develop DVT, though none had clinical signs suggestive of it. One case involved the femoral and another the popliteal vein. No patient developed pulmonary embolism. As the incidence of DVT after ankle fractures is low, we do not recommend routine thromboprophylaxis.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 7 | Pages 962 - 970
1 Jul 2007
Albert C Patil S Frei H Masri B Duncan C Oxland T Fernlund G

This study explored the relationship between the initial stability of the femoral component and penetration of cement into the graft bed following impaction allografting.

Impaction allografting was carried out in human cadaveric femurs. In one group the cement was pressurised conventionally but in the other it was not pressurised. Migration and micromotion of the implant were measured under simulated walking loads. The specimens were then cross-sectioned and penetration of the cement measured.

Around the distal half of the implant we found approximately 70% and 40% of contact of the cement with the endosteum in the pressure and no-pressure groups, respectively. The distal migration/micromotion, and valgus/varus migration were significantly higher in the no-pressure group than in that subjected to pressure. These motion components correlated negatively with the mean area of cement and its contact with the endosteum.

The presence of cement at the endosteum appears to play an important role in the initial stability of the implant following impaction allografting.


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 7 | Pages 928 - 932
1 Jul 2006
Patil S Montgomery R

We reviewed 78 femoral and tibial nonunions treated between January 1992 and December 2003. Of these, we classified 41 in 40 patients as complex cases because of infection (22), bone loss (6) or failed previous surgery (13). The complex cases were all treated with Ilizarov frames. At a mean time of 14.1 months (4 to 38), 39 had healed successfully.

Using the Association for the Study and Application of the Methods of Ilizarov scoring system we obtained 17 excellent, 14 good, four fair and six poor bone results. The functional results were excellent in 14 patients, good in 14, fair in two and poor in two. A total of six patients were lost to follow-up and two had amputations so were not evaluated for final functional assessment. All but two patients were very satisfied with the results. The average cost of treatment to the treating hospital was approximately £30 000 per patient.

We suggest that early referral to a tertiary centre could reduce the morbidity and prolonged time off work for these patients. The results justify the expense, but the National Health Service needs to make financial provision for the reconstruction of this type of complex nonunion.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 301 - 301
1 Sep 2005
Colwell C Hermida J Patil S D’Lima D Dimaano F Hawkins M
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Introduction and Aims: Titanium foam implants simulate the trabecular structure of bone to maximise porous space for bone ingrowth. Plasma-sprayed hydroxyapatite coatings work well on non-porous substrates but do not coat the inner surfaces of open-porous substrates. Chemical deposition is an attractive alternative that produces consistent coats on porous surfaces.

Method: Titanium foam cylinders (5mm diameter by 25mm length) were implanted bilaterally in 40 rabbit femurs. Twenty implants were coated with 20 microns of hydroxyapatite (T-HA) by electrochemical deposition while 20 implants had no hydroxyapatite coat (T). Osseointegration was measured at six and 12 weeks by automated computerised histomorphometry of scanning electron microscopy images of sections taken through the implant at two levels: diaphyseal and metaphyseal. Bone ingrowth was quantified in the pores and was also measured up to 1mm beyond the surface of the implant to determine the pattern of bone growth.

Results: For the T-HA surface, bone ingrowth increased from 35.0 ±8.5 % at six weeks to 41.5 ± 7.4 % at 12 weeks (p < 0.05). For the T surface, bone growth was 14.1 ± 8.8% at six weeks and 11.4 ± 4.2 % at 12 weeks. At both time points mean bone ingrowth was significantly different between hydroxyapatite-coated and non-hydroxyapatite-coated implants, (p< 0.01). No significant differences were noted between the diaphyseal and metaphyseal bone response.

Conclusion: For the T-HA surface, bone ingrowth increased from 35.0 ±8.5 % at six weeks to 41.5 ± 7.4 % at 12 weeks (p < 0.05). For the T surface, bone growth was 14.1 ± 8.8% at six weeks and 11.4 ± 4.2 % at 12 weeks. At both time points mean bone ingrowth was significantly different between hydroxyapatite-coated and non-hydroxyapatite-coated implants, (p< 0.01). No significant differences were noted between the diaphyseal and metaphyseal bone response.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 342 - 343
1 Sep 2005
Colwell C Patil S Ezzet K Kang S D’Lima D
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Introduction and Aims: A significant proportion of patients currently undergoing total knee arthroplasty have uni-compartmental disease. Unicondylar knee replacement (UKA) offers the benefits of less bone resection and better soft tissue retention. However, knee kinematic changes after UKA have not been established.

Method: A significant proportion of patients currently undergoing total knee arthroplasty have uni-compartmental disease. Unicondylar knee replacement (UKA) offers the benefits of less bone resection and better soft tissue retention. However, knee kinematic changes after UKA have not been established.

Results: In the normal knee, knee flexion was accompanied by femoral rollback and tibial internal rotation. Similar patterns of rollback and rotation were seen after UKA. Surprisingly, resecting the ACL did not affect rollback or tibial rotation. However, tibial rotation was significantly different and was more variable after TKA. This suggests that loss of the ACL may not be the major cause of abnormal kinematics after TKA.

Conclusion: Abnormal kinematics have been previously reported after TKA. However, UKA appeared to maintain normal kinematics. This study reported kinematic advantages to UKA, in addition to less bone resection and better recovery.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 340 - 340
1 Sep 2005
Colwell C D’Lima D Patil S Steklov N
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Introduction and Aims: Complications after total knee arthroplasty (TKA) have been attributed to soft-tissue imbalance. The current approach to soft-tissue balance is static measurements in extension and 90 degrees flexion. Dynamic balancing during the entire range of flexion may be more valuable.

Method: Complications after total knee arthroplasty (TKA) have been attributed to soft-tissue imbalance. The current approach to soft-tissue balance is static measurements in extension and 90 degrees flexion. Dynamic balancing during the entire range of flexion may be more valuable.

Results: All knees (in vitro and in vivo) initially recorded imbalance in the tibial forces: mean 18N (6–72) in the mediolateral and 26N (13–108) in the anteroposterior direction. After soft-tissue balancing, the mean imbalance reduced by 87%. Even when knees appeared well balanced at zero and 90-degree flexion, there was imbalance [mean 22N (2–34)] at flexion angles between zero and 90 degrees. The 2mm thicker insert increased forces by a mean of 89% (22–180%).

Conclusion: Soft-tissue balance in TKA remains a complex concept. The routine instruments used for soft-tissue balance only detect mediolateral imbalance. Even when accurate static balancing was achieved, dynamic measurements revealed imbalance in mid-flexion. These results explain some of the variability in knee kinematics after TKA and the incidence of mid-flexion instability.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 5 - 5
1 Jan 2004
Hermida J Patil S Chen P Colwell C D’Lima D
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This study measured polyethylene wear and correlated it with design features such as tibiofemoral conformity and contact areas.

Two femoral component designs were tested in a knee wear simulator. The femoral condyles of design A were flat-on-flat in the coronal plane, while those of design B were curved-on-curved. These femoral components were tested with two inserts. Insert PLI had a posterior lip, while insert C had a more curved sagital geometry, to improve stability in the anteroposterior direction. All components were tested for up to five million cycles in bovine serum lubricant. Triaxial forces were monitored to ensure that loading conditions were similar in all combinations tested. Gravimetric wear measurements were made at 500 000 cycle intervals. Contact stresses were measured using pressure sensitive film and dynamic finite element analysis.

Contact stresses were 22% higher for inserts tested with design A compared to design B. Sliding distance, sliding velocity, and patterns of crossing motion were found to be comparable between the two femoral designs. Inserts tested with design A wore significantly more (mean 10.9 mg/million cycles) than design B (mean 5.71 mg/million cycles, p < 0.001). No appreciable differences were found between wear rates of insert PLI and insert C.

Component design can have a significant impact on polyethylene wear rate. Careful control of kinematic and loading conditions allowed for comparison between specific design features. Increase in tibio-femoral contact area led to reduction of contact stresses, which was reflected in the reduced wear rate.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 101 - 101
1 Feb 2003
Patil S Mackay G Taylor M Keene G Paterson R
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The purpose of this study was to determine if routine x-ray exposure produced any chemical oxidation of Ultra High Molecular Weight Polyethylene (UHMWPE), used for joint arthroplasty.

Three different polyethylene polymers were obtained from Biomet, Depuys and Howmedica. These samples had undergone sterilisation and packaging methods. Rectangular shapes of polymer were cut according to the standards specified by the ASTM (American Society For Testing and Materials). Eight samples of each polymer were obtained and divided randomly in to test and control subgroups. The test samples were exposed to ten x-rays with the standard dose used for the hip joint.

Polyethylene oxidation was measured using Fourier transform infrared spectroscopy. This technique can assess the incorporation of oxygen within the carbonyl region. Radiated and non-irradiated samples were compared in each polymer group.

Oxidation from the Fourier transform infrared spectroscopy was quantified by calculating the area under a signature absorption peak for UHMWPE (methylene band at 1370 cm-1) and an oxidation absorption peak (carbonyl band at 1720 cm-1). The ratio of the area of the oxidation peak to the area of the signature peak yields the carbonyl content, or oxidation, relative to the amount of polyethylene. There was no significant difference in oxidation after exposure to x-rays between test and control UHMWPE samples.

Although numerous studies have looked in to the effects of high dose radiation exposure on polyethylene, effects of routine x-rays have not been studied before. It is common practice to follow-up patients with joint replacements over a long period with xrays at each visit. Present study examined the effects of routine x-rays on oxidation of polyethylene. However there was no detectable oxidation after exposure to x-rays. This study paves way for further research in this direction.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 102 - 102
1 Feb 2003
Patil S Shaw R
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It has been recently suggested that hyponatraemia may be a cause of significant iatrogenic harm in orthopaedic patients. In an attempt to test this theory, this observational study was done to establish the incidence of post-operative hyponatraemia following hip fracture and evaluate its correlation with outcome.

An observational study was carried out on 213 consecutive hip fracture patients. 201 patients completed the requirements of the study (Male-45, Female-156). Mean age was 80 years. Serum sodium concentrations were recorded during the first week of admission. Hyponatraemia defined as significant (Na < 130mmol/L) was identified in 9% at admission and 18% during first week of stay. Incidence of severe hyponatraemia was 3%. There were no acute complications of hyponatraemia in these patients. 78% of hyponatraemia patients had received 5% Dextrose infusion during the postoperative period as their main intravenous fluid. All hyponatraemic patients had their sodium levels restored to normal during their stay.

Long term outcome measures used were mortality, change in residential status, walking ability and use of walking aids at 4 months following fracture. There was 20% mortality at 4 months in the hyponatraemic group and it was 30% in the normal serum sodium group. However this difference was not statistically significant. Hyponatraemia did not significantly influence deterioration in residential status (p< 0. 05), walking independence (p< 0. 05) or increase of walking aids (p< 0. 05).

In hip fracture patients, hyponatraemia whilst common was not associated with a poor outcome and at the same time we did not find any evidence of lapse in the recognition and treatment of hyponatraemia in a general orthopaedic ward. However emphasis should be made to junior medical staff to avoid iatrogenic hyponatraemia by following a proper postoperative fluid regime.


The Journal of Bone & Joint Surgery British Volume
Vol. 81-B, Issue 3 | Pages 557 - 557
1 May 1999
COLLIER AM PATIL S


The Journal of Bone & Joint Surgery British Volume
Vol. 76-B, Issue 4 | Pages 607 - 609
1 Jul 1994
Mody B Patil S Carty H Klenerman L

We describe three cases of traumatic myositis ossificans in which fractures occurred through a mature, quiescent ossification mass. None of the fractures reactivated the original pathological process, no callus was formed and union did not occur. The nonunion became painless over a period of months. This unusual late complication of myositis ossificans seems to require only symptomatic treatment by temporary splintage and subsequent mobilisation. We could find no previous report of a similar case.