Our aim was to determine the success rate of repeated debridement and two-stage cementless revision arthroplasty according to the type of infected total hip replacement (THR). We enrolled 294 patients (294 hips) with an infected THR in the study. There were 222 men and 72 women with a mean age of 55.1 years (24.0 to 78.0). The rate of control of infection after the initial treatment and after repeated debridement and two-stage revisions was determined. The clinical (Harris hip score) and radiological results were evaluated. The mean follow-up was 10.4 years (5.0 to 14.0).

The eventual rate of control of infection was 100.0% for early superficial post-operative infection, 98.4% for early deep post-operative infection, 98.5% for late chronic infection and 91.0% for acute haematogenous infection. Overall, 288 patients (98%) maintained a functioning THR at the latest follow-up. All the allografts appeared to be united and there were no failures.

These techniques effectively controlled infection and maintained a functional THR with firm fixation in most patients. Repeated debridement and two-stage or repeated two-stage revisions further improved the rate of control of infection after the initial treatment and increased the likelihood of maintaining a functional THR.

Background: Whether total knee arthroplasty using computer-assisted surgical navigation can improve the limb and component alignment is a matter of debate. We hypothesized that total knee arthroplasty using computer-assisted surgical navigation is superior to the conventional total knee arthroplasty with regard to the precision of implant positioning.

Methods: Sequential simultaneous bilateral total knee arthroplasties were carried out in 160 patients (320 knees). One knee was replaced using a computer-assisted surgical navigation system and the other conventionally without using computer-assisted surgical navigation. The two methods were compared for accuracy of orientation and alignment of the components determined by radiographs and computed tomographs. The mean follow-up was 3.4 years.

Results: The mean preoperative Knee Society score was 26 points in the computer-assisted total knee arthroplasty group, which was improved to 92 points postoperatively and it was 25 points, which improved to 93 points post-opertively in the conventional total knee arthroplasty group. Ranges of motion of the knees were similar in both groups. The operating and tourniquet times were significantly longer in the computer-assisted total knee arthroplasty group than in the conventional total knee arthroplasty group (P< 0.001). Accuracy and the number of outliers of component position between the two groups were not significantly different (P> 0.05).

Conclusions: Our data demonstrated that total knee arthroplasty using computer-assisted surgical navigation did not result in more accurate implant positioning than that achieved in conventional total knee arthroplasty, determined by both radiographs and computed tomographs.

Background: The main goals of total knee arthroplasty are pain relief and improvement of function and range of motion. To ascertain whether posterior cruciate-retaining-flex total knee prosthesis would improve pain, function and range of motion, we asked whether knee and pain scores, ranges of motion, WOMAC score, patient satisfaction, and radiographic results would be better in the knees with a high-flexion posterior cruciate-retaining prosthesis than in the knees with a standard posterior cruciate-retaining prosthesis.

Methods: Fifty-four patients (mean age, 69.7 years) received a standard posterior cruciate-retaining knee prosthesis in one knee and a high-flexion posterior cruciate-retaining knee prosthesis in the contralateral knee. Five patients were men, and forty-nine were women. The minimum follow-up was three years (mean 3.1 years). At each follow-up, the WOMAC score and range of knee motion were evaluated and patients were assessed clinically and radiographically with use of the knee-rating systems of the Knee Society and The Hospital for Special Surgery.

Results: The mean postoperative Knee Society and Hospital for Special Surgery knee scores were 93.7 and 89 points, respectively in the knees with a standard posterior cruciate-retaining prosthesis and those were 93.9 and 90 points, respectively in the knees with a high-flexion posterior cruciate-retaining prosthesis. The mean postoperative WOMAC score was 22 points. Postoperatively, the mean non-weight and weight bearing ranges of motion were 131° (range, 90° to 150°) and 115° (range, 75 to 145°), respectively in the knees with a standard prosthesis and those were 133° (range, 90° to 150°) and 118° (range, 75 to 145°), respectively in the knees with a highflexion prosthesis. Patients satisfaction and radiographic results were similar in both groups. No knee had aseptic loosening, revision, or osteolysis.

Conclusions: After a minimum follow-up of three years, we found no significant differences between the two groups with regard to range of knee motion or clinical and radiographic results.

We undertook a study in which 138 female patients with a mean age of 71.2 years (51 to 82) received a standard NexGen CR-flex prosthesis in one knee and a gender-specific NexGen CR-flex prosthesis in the other. The mean follow-up period was 3.25 years (3.1 to 3.5). The aspect ratios of the standard and gender-specific prostheses were compared with that of the distal femur.

The mean post-operative Knee Society knee scores were 94 (70 to 100) and 93 (70 to 100) points and the function scores were 83 (60 to 100) and 84 (60 to 100) points for the standard implants and the gender-specific designs, respectively. The mean post-operative Western Ontario and McMaster Universities score was 26.4 points (0 to 76). Patient satisfaction, the radiological results and the complication rates were similar in the two groups. In those with a standard prosthesis, the femoral component was closely matched in 80 knees (58.0%), overhung in 14 (10.1%) and undercovered the bone in 44 (31.9%). In those with a gender-specific prosthesis, it was closely matched in 15 knees (10.9%) and undercovered the bone in 123 (89.1%).

Since we found no significant differences between the two groups with regard to the clinical and radiological results, patient satisfaction or complication rate, the goal of the design of the gender-specific CR-flex prosthesis to improve the outcome was not achieved in our patients.

The osseointegration of implants is related to the early interactions between osteoblastic cells and titanium surfaces. The behavior of osteoblast cells was compared on four different titanium surfaces in vitro and in vivo: machined, blasted, plasma spray and micro-arc oxidation.

X-ray diffraction and scanning electron microscope investigations were performed in order to assess the structure and morphology. Biologic and morphologic responses to the osteoblast cell lines (Saos-2) were then examined, using Promega proliferation assay, alkaline phosphatase activity, vβ3 integrin expression and cytoskeleton staining (Rhodamine-Phallodine). The analysis of gene expression for osteocalcin and collagen I was done through RT-PCR. In addition, differential histologic evaluation and interfacial strength at the bone-implant interfaces were then evaluated in the distal femur of four beagle dogs.

In conclusion, micro-arc oxidation of titanium appears to exhibit more favorable osteoblast adhesion and stronger interfacial strength than the compared groups in vitro and in vivo as well.

The purpose of this study is to identify clinical and radiographic results of 78 uncemented total hip arthroplasties using Metasul^® metal on metal bearings with Wagner standard cup and proximal hydroxyapatite coated CLS stem.

Mean age was 39 years and average follow-up period was 11.7 years. Mean Harris hip score had improved from 51.4 points preoperatively to 95.2 points finally. There were 2 hips with progressive osteolysis around the acetabular cup. Of them, one hip was revised due to loosening of the cup, and the other was observed because of patient’s refusal to revise. In histopathologic findings on osteolytic area, a lot of macrophage phagocytizing metal debris and perivascular lymphocyte infiltration were found. Immunohistochemical analysis suggested delayed metal hypersensitivity. Serum cobalt levels in hips with osteolysis were not higher than those in hips without osteolysis.

Early osteolysis with sudden onset of groin pain in few hips remains a concern.

We hypothesized that navigation can help provide a well-balanced knee, through real-time feedback of alignment accuracies and gap sizes in flexion and extension. The purpose of this study was to evaluate in vivo stabilities of mediolateral laxity in full extension and anteroposterior laxities in 90° of flexion after navigation-assisted total knee arthroplasty, and to determine the nature of the correlations between these and range of motion (ROM).

Forty-two total knee arthroplasties performed using a navigation system with a minimum two-year follow-up were included. The following were measured at final follow-ups; mediolateral laxities at extension and anteroposterior laxities at 90 degrees of flexion (using stress radiographs and a Telos arthrometer), modified HSS scores (excluding laxity and range of motion), and range of motion (ROM).

At final follow-up the mean modified HSS score was 82% of total points and mean postoperative ROM was 128.1 ± 10.4°. Mean medial laxity was 3.5 ± 1.4°, mean lateral laxity 4.4 ± 2.2°, and mean anteroposterior laxity 7.1 ± 4.1 mm. We found no significant correlation between mediolateral laxity and postoperative ROM. However, a significant correlation was found between postoperative ROM and anteroposterior laxity.

In the present study, the use of a navigation system in total knee arthroplasty was found to improve in vivo stability and produce promising short-term clinical results.

Summary: Using a navigation system in total knee arthroplasty, we obtained good in vivo stability and found the positive correlation between the range of motion and anteroposterior laxity

The use of polymethylmethacrylate (PMMA) in orthopaedic reconstructive surgery can increase the possibility of cardiovascular dysfunction remains a debate. This study was undertaken to determine if cemented hemiarthroplasty is safe in treatment of femoral neck fracture in patients with ischemic heart disease. Between March 1999 and February 2004, we performed cemented hemiarthroplasties for displaced femoral neck fractures on 158 consecutive patients. This retrospective study consisted of 44 patients with ischemic heart disease(group 1) and 58 patients of age matched control(group 2). We compared the mortality rate, the incidence of deep vein thrombosis (DVT), pulmonary embolism, cerebrovascular disease, dislocation, deep infection, the amount of postoperative blood loss, and the grade of cementation by Barrack in radiograph between two groups.

No difference was found in perioperative mortality rate, deep infection rate, the incidence of DVT or pulmonary embolism, the newly developed heart ischemic event or brain hemorrhagic lesion between the two groups. But there were more incidence of dislocation related to weakness by past brain ischemic lesion and the newly developed brain ischemia in patients of group 1 than group 2(p < 0.05). More importantly, six patients in group 1 had transient symptoms of dyspnea, signs of hypotension, and bradycardia during two days postoperatively, which is suspicious of embolic phenomenon, even though it was not confirmed.

More closer and careful observations for the occurrence of dislocation related to previous brain ischemia, or newly developed brain ischemic lesion or embolic phenomenon and appropriate thromboprophylaxis are necessary in patients with ischemic heart disease after a cemented hemiarthroplasty for the treatment of femoral neck fracture.

Computer navigation for total knee arthroplasty (TKA) has been increasingly used because it improves the accuracy of implant placement. However, some clinical cases have reported complications caused from pin holes during the computer navigated surgery. The objective of this study is to analyse the femoral fracture risk cause by the pin hole in the computer navigated TKA by using finite element analysis.

Three dimensional finite element model of the human femur was developed from CT images. A parametric investigation was conducted to analyse the femoral fracture risk for the following parameters: hole sizes (3, 4, and 5 mm) and hole position (70, 100, and 130 mm above the distal end). Four different penetrations (unicortical, bicortical, half-bicortical, and transcortical) methods in tubular bone were considered in each model, where the half-bicortical penetration was defined that the pin hole was located between the holes of bicortical and transcortical penetrations. The finite element model was rigidly fixed to a distance of 25 mm above the distal end. The vertical load of 1500 N and the torsional load of 12 Nm were applied to the femoral head. The maximum von-Mises stress, which was chosen as the fracture risk factor, was then investigated around pin hole.

The maximum von-Mises stress around the pin hole was the highest in the transcortical penetration for different hole sizes: 7.8~8.5, 15.7~16.2, 15.5~16.8, and 25.5~45.3 MPa under the vertical load, and 9.6~10.5, 9.7~11.0, 8.8~10.2, and 14.2~33.8 MPa under the torsional load in unicortical, bicortical, half-bicortical, and transcortical penetrations, respectively. For the different hole position, the maximum von-Mises stress around the pin hole was: 6.0~7.8, 15.7~24.7, 16.3~19.6, and 12.2~22.4 MPa under the vertical load, and 9.6~10.7, 9.7~11.5, 8.7~9.8, and 12.2~16.6 MPa under the torsional load in unicortical, bicortical, half-bicortical, and transcortical penetrations, respectively.

For the pin hole size, the maximum stress increased only in the transcortical penetration regardless of the loads as the pin hole size increased. However, there was little meaningful difference between the hole positions for each penetration method. The results of this study suggested that it would be beneficial to avoid using the transcortical penetration and large size of pin with respect to reduction of femoral fracture risk since the high stress may cause the femoral fracture.

Even though spinal fusion has been used as one of the common surgical techniques for degenerative lumbar pathologies, high stiffness in the fusion segment could generate clinical complications in the adjacent spinal segment. To avoid these limitations of fusion, the artificial discs have recently used to preserve the motion of the treated segment in lumbar spine surgery. However, there have been lacks of biomechanical information of the artificial discs to explain current clinical controversies such as long-term results of implant wear and excessive facet contact forces. In this study, we investigated the biomechanical performance for three artificial discs in the lumbar spinal segments by finite element analysis.

A three-dimensional finite element model of five spinal motion segments, from L1 to S, in intact lumbar spine was reconstructed from CT images. Finite element models of three artificial discs, semi-constrained and metal on polyethylene core type (ProDisc^® II, Spine Solutions Inc., USA; Type I), semi-constrained and metal on metal type (MaverickTM, Medtronic Sofamor Danek Inc., USA; Type II), and un-constrained and metal on polyethylene core type (SB ChariteTM III, Dupuy Spine Inc., Switzerland; Type III) were developed. Each artificial disc was inserted at L4–L5 segment, respectively. Upper and lower plates of artificial discs were attached on the L4 and L5 vertebrae. Some parts of ligaments and intervertebral disc in L4–L5 motion segment were removed to insert artificial discs. Nonlinear contact conditions were applied on facet joints in lumbar spine model and artificial discs. Bottom of sacrum was fixed on the ground and 5Nm of flexion and extension moments were applied on the superior plate of L1 with 400N of compressive load along follower load direction.

In extension, all three artificial disc models showed higher rotation ratio at the surgical levels, but lower rotations at the adjacent levels than those in the intact model. There was no big difference of the intersegmental rotations among the artificial disc models. For the comparison of the peak von-Mises stresses on the polyethylene core in flexion, 52.3 MPa in type I implant was higher than 20.1 MPa in Type III implant while the peak von-Mises stresses were similar, 25.3 MPa and 26.5 MPa in Type I and III, respectively in extension. The facet contact forces at the surgical level for the artificial disc models showed 140 to 160 N in extension whereas the facet contact force in the intact model was 60 N.

From the results of this study, we could investigate the biomechanical characteristics of three different artificial disc models. The relative rotation at the surgical level would be increases at the early outcome after total disk replacement. The semi-constrained type artificial disc could generate higher wear risk of the implant than unconstrained type. Also all types of artificial disc model have higher risk of facet joint arthrosis, and especially in the semi-constrained and metal on metal type. The results of the present study suggested that more careful care must be taken to choose surgical technique of total disc replacement surgery.

Sixty primary hip arthroplasties were performed in Crowe grade 2 to 4 hip dysplasia since 1973 using a modified transtrochanteric osteotomy which is reliable short cut to reach down the lateral aspect of the greater trochanter. Our hypothesis consists of the adaptability of Thomas test to show the reducibility of the disloction in the coronal plane. In practice, if the dynamic potential while abduction and flexion exceeds from the 90° to coronal plane, the femoral head slips down to the acetabulum through poor sciatic notch. Thereby led to Protrusio acetabulii which implicative compromised capsular insufficiency but assessment of outcome study has been improved.

The results have been reasonably acceptable, with the longest follow-up greater than 35 years. We confirmed that the frog leg lateral radiography is effective for determining the operative indication of high riding dislocation of the DDH. However irreducible frog leg lateral position is absolutely contraindicated in these situation. We also aware of not only the complexity in abductor length but abundant amount of vastus lateralis when reattaching the trochanter, which may arises against stability of the abductors and vastus lateralis in continuity.

Spinal fusion has been used as the gold standard to treat some spinal disorders such as degenerative disc or disc herniation of the cervical spine. However, some clinical complications have been reported caused by high stiffness of spinal fusion. Recently, total disc arthroplasty using motion preservation devices such as artificial discs (ADs) have been proposed as an alternative treatment technique. In current study, we analysed biomechanical influences including inter-segmental motion, facet joint forces, and ligament stresses of two different clinical available ADs and compared with those of intact cervical spine in various loading conditions using finite element analysis.

A three dimensional finite element model was developed for C2-C7 spinal motion segment based on CT images and previous anatomical literatures. The finite element models for two different types of ADs, semi-constraint (Prodisc-C^®, Synthes, U.S.A) and un-constraint (Mobi-C^®, LDR Spine, U.S.A), were developed. Each AD was inserted at C6–C7 segments. Superior and inferior plates of ADs were fixed on inferior plane of C6 and superior plane of C7 vertebrae, respectively. Based on the conventional surgical techniques, anterior longitudinal ligaments and some parts of intervertebral disc in C6–C7 motion segment were removed to insert ADs. Inferior plane of C7 vertebra was constrained in all directions and 1Nm of flexion, extension, lateral bending and torsion were applied on superior plane of C2 vertebra with 50N of compressive load along follower load direction.

Rotation angle in flexion of C5–C6 segment in cases of semi-constraint and un-constraint AD was 3.3° and 3.7°, respectively. Both values were greater than that in case of the intact cervical spine by 18% and 32%, respectively. Rotation angle in extension, lateral bending and torsion were greater than intact model by 45%, 26% and 43% for the case of semi-constraint AD and 55%, 35%, 100% for the case of un-constraint one, respectively. In extension, facet joint forces were about two times higher than intact model in cases of semi-constraint and un-constraint AD. Also in flexion, on average, ligament stresses in cases of semi-constraint and un-constraint AD were higher than intact model by 66% and 116%, respectively.

The results of this study showed that ADs were useful to generate inter-segmental motion at surgical level. And the un-constraint type of AD had higher mobility than semi-constraint one. However, high mobility of ADs would lead not only higher facet joint forces but also ligament stresses than intact cervical spine. Therefore, more careful care must be taken to choose surgical method of total disc arthroplasty.

The high-flex total knee arthroplasty system was introduced to enhance knee flexion and to facilitate tibiofemoral articulation at high-flexion by the design modification of an increased thickness of the posterior wall of the femoral component by 2 mm compared with the standard total knee prosthesis. However, several clinical studies on the effectiveness of designs intended to provided high flexion following total knee arthroplasty have produced conflicting results. We performed a prospective, randomized study to compare the ranges of motion of the high-flex and standard total knee replacements in patients who were managed with simultaneous bilateral total knee arthroplasty.

This study comprised of three independent groups of patients.

The first group: Fifty patients (mean age, 68 years old) received a standard NexGen LPS prosthesis in one knee and a NexGen LPS-Flex prosthesis in the contralateral knee. Two patients were men, and 48 were women. At a mean of 2.1 years postoperatively, the patients were assessed clinically and radiographically with use of the knee-rating systems of the KS and HSS.

After a minimum follow-up of two years, we found no significant differences among the first, second and the third groups with regard to range of knee motion, or clinical and radiographic results.

In the knee joint surgery such as total knee arthroplasty (TKA), the implant should be inserted in proper position with correct bone alignment because the abnormal kinematics of implanted knees by implant mal-positioning or mal-alignment could cause failure of surgery. Therefore, quantitative information of a 3D kinematics of the knee joint is very helpful to evaluate the surgical treatment such as planning of size and alignment of the implant. In this study, a 2D/3D image matching method was developed to estimate the kinematics of the knee joint based on an automated pixel by pixel comparison of images.

Two projection images were obtained from the 3D object in two perpendicular directions where the given dual X-ray images were taken. The 3D object was translated and rotated automatically and continuously until its projection images were matched with the X-ray images in a given tolerance range. The optimization algorithm was used to minimise the root mean square error between the gray scale values of each pixel in the projection image and the given X-ray image. For estimating the position and orientation of the knee joint, the 3D knee joint models were reconstructed from CT data. The 3D model was matched with the given dual X-ray images by using the developed 2D/3D image matching method. The tibial and femoral components were then combined into the whole knee joint model. By adding fiducial markers based on clinically conventional method, the posterior and mediolateral translation of femur with respect to tibia as well as the flexion angle were measured.

In the experiment with the cubic phantom, the position errors were below 0.10 mm and the orientation errors were below 0.05 o when using dual X-ray images. For the given dual X-ray images, the relative in vivo kinematics of the femur was measured as the posterior translation was 3.0 mm and the mediolateral translation was 0.9 mm. In addition, the flexion angle of the knee joint from the sagittal view was 51o while the angle measured from the given X-ray image was 50 o.

The previous 2D/3D image matching methods operated manually took long time and was dependent on the operator. Recently, automated image matching method has developed by applying optimization algorithms. In this study, the optimal position and orientation were obtained by the direct pixel by pixel comparison, which are easy to implement and modify the algorithm. The present automated method could accelerate the matching process and stabilise the repeatability. In addition, the image matching method with dual images was used to improve the out-of-plane accuracy since the image matching method with a single X-ray image has a limitation of methodology in detecting out-of-plane translation and rotation though the in-plane accuracy was acceptable. The present 2D/3D image matching method is a powerful tool for the accurate determinations of 3D position and orientation of the knee joint and could provide informative characterization of implant designs and surgical options of the knee surgery.

Background: A common clinical scenario encountered by an orthopaedic surgeon is a patient with a secure cementless acetabular shell and a failed polyethylene liner. One treatment option is to cement a new liner into the fixed shell. The purpose of this study was to evaluate the radiographic outcome of this technique.

Materials and Methods: From November 2001 to April 2006, 11 liner were cemented into well-fixed cementless acetabular shell of 10 patients. There were 6 males and 5 women of average age 54.3 (range 41~73) years at the time of the revision surgery. The indication for the revision procedure were aseptic loosening and wear in 9 cases, and periprosthetic fracture in 2 cases. The pre-existing screws in the shell were removed, and screw holes were filled with allogenic bone graft or cementaion. The patients were evaluated the radiographic evidence of progressive loosening and osteolysis. The average follow up period was 35.2 (range 24~76) months.

Results: There were no changes in cup and liner position or progression of osteolytic lesion around the femoral or acetabular components in the last follow-up radiographs. No compications such as a deep or superficial infection or deep vein thrombosis occurred. There were no hip dislocations.

Conclusion: A liner cemented into a secure, well-positioned cementless acetabular shell provide stability and durability at short and long term follow up. This technique also has advantages of preventing bone loss associated with removal of a well fixed component, and lower surgical morbidity and more liner options. Careful attention to the preparation of the liner, the sizing of the component, and the cementing technique are likely to reduce the failure of this construct.

Background: Ceramic-on-ceramic couplings are an attractive alternative bearing surfaces to eliminate or reduce problems related to polyethylene wear debris. Past disappointing experiences with alumina ceramic bearings have led to many improvements in the manufacture and the design of ceramic implants. The purpose of this study was to report the results of contemporary alumina-on-alumina total hip arthroplasties (THAs) with regard to wear, osteolysis, and fracture of the ceramic after a 10-year minimum follow-up.

Methods: We evaluated the results of a series of 66 primary alumina-on-alumina THAs with a metal-backed socket and a cementless stem in 59 patients. All of the patients were 64 years old or younger (mean, 42 years), and a single surgeon performed all of the procedures. They were evaluated clinically and radiographically at the 120 to 126 months follow-up (average, 123 months). During the follow-up, special regards were addressed to wear, periprosthetic osteolysis and ceramic failure.

Results: During the follow-up period, two patients (two hips) had died with the prosthesis in situ as the result of an unrelated medical condition. The mean Harris hip score was 94 points at the latest follow-up evaluation. All of the prostheses had radiographic evidence of a bone ingrowth. No implant was loosened radiographically and no implant was revised. Ceramic wear was not detectable in the 28 hips where differentiation of the femoral head from the cup was possible on radiographs. Periprosthetic osteolysis was observed in no hip. A fracture of the alumina femoral head and a peripheral chip fracture of the alumina insert occurred in one hip following a major motor vehicle accident. A periprosthetic femoral fracture, which required open reduction and internal fixation with metal cables, had occurred in one hip. This fracture healed without problem.

Conclusion: The results of contemporary alumina-on-alumina THAs with a metal-backed socket and a cementless stem were encouraging after a minimum follow up of 10 years. We believe that these improved alumina-on-alumina bearing implants offer a promising option for younger active patients.

Biocompatibility of Co-Cr alloy was significantly improved by forming rough TiO2 layer on the surface. The TiO2 layer was formed by coating the Co-Cr alloy with Ti through electron beam deposition followed by micro-arc oxidation (MAO) of the Ti. Biocompatibility of Co-Cr alloy was enhanced by coating with titanium, and it was improved further by micro-arc oxidation treatment. MAO process was dependent on the thickness of coated titanium layer and applied voltage. There were close relationships between the phase, morphology and thickness of TiO2 layer and the applied voltage. Biocompatibility of the specimens coated with Ti and MAO treated after Ti coating were evaluated by in vitro ALP activity tests.

The purpose of this study was to examine surface characteristics of 30 alumina and 24 zirconia ceramic femoral heads and to identify phase transformation in zirconia heads. We also studied penetration rate of alumina and zirconia heads into UHMWPE liner. The alumina heads had been implanted for a mean of 11.3 years (8.1 to 16.2) and zirconia heads for a mean of 9.8 years (7.5 to 15).

The mean surface roughness values of explanted alumina heads (Ra 40.12 nm and Rpm 578.34 nm) were similar to those for the explanted zirconia heads (Ra 36.12 nm and Rpm 607.34 nm). The mean value of monoclinic phase of two control non-implanted zirconia heads was 1% (0.8–1.5) and 1.2% (0.9–1.3), respectively. The mean value of monoclinic phase of 24 explanted zirconia heads was 7.3% (1% to 26%).

In the alumina head group, mean linear penetration rate of UHMWPE liner was 0.10 mm/yr (0.09 to 0.12) in hips with low Ra and Rpm values (13.22 nm and 85.91 nm, respectively). The mean linear penetration rate of UHMWPE liner was 0.13 mm/yr (0.17 to 0.23) in the hips with high Ra and Rpm values (198.72 nm and 1329 nm, respectively). This differences was significant (P=0.041)

In the zirconia head group, the mean linear penetration rate of UHMWPE liner was 0.09 mm/yr (0.07 to 0.14) in hips with low Ra and Rpm values (12.78 nm and 92.99 nm, respectively). The mean linear penetration rate of UHMWPE liner was 0.12 mm/yr (0.08 to 0.22) in hips with high Ra and Rpm values (199.21 nm and 1381 nm, respectively). This difference was significant (P=0.039).

The explanted zirconia heads which had a minimal phase transformation had similar surface roughness and a similar penetration rate of UHMWPE liner as the explanted alumina head.

Architectural changes in occurring in the proximal femur (resorption) after total hip arthroplasty (due to stress shielding) continues to be a problem. In an attempt to reduce these bony changes the concept of short and femoral neck sparing stem designs have been advocated. The purpose of this study was to evaluate the early clinical and radiological results, especially stem fixation and bone remodeling of proximal femur after total hip arthroplasty.

A total of forty-five patients (fifty-four hips) were included in the study. There were twenty men and twenty-five women. The mean age at the time of operation was 53.9 years (range, twenty-six to seventy-five years). Clinical and radiological evaluation were performed at each follow-up. Bone densitometry was carried out on all patients one week after operation and at the final follow-up examination. The mean follow-up was 1.3 years (range, one to two years).

The mean preoperative Harris hip score was 45 points (range, 15 to 48 points), which improved to a mean of 96 points (range, 85 to 100 points) at the final follow-up. No patient complained of thigh pain at any stage. No acetabular or femoral osteolysis was observed and no hip required revision for aseptic loosening of either component. One hip (2%) required open reduction and fixation with a cable for calcar femorale fracture. Bone mineral densitometry revealed a minimal bone remodeling in the acetbulum and proximal femur.

The geometry of this ultra-short anatomic neck sparing cementless femoral stem has proved to provide effective initial stability even without the diaphyseal portion of the stem. We believe that femoral neck preservation and lateral flare of the stem provide an axial and torsional stability and more natural loading of the proximal femur.

Modified posterior approach preserving short external rotators would be able to contribute greatly to prevent dislocation after total hip arthroplasty. We modified the posterior approach to the hip by preserving the external rotator muscles in order to enhance joint stability after total hip arthroplasty in patients with osteonecrosis of the femoral head. The aim of the this study was to determine the influence of external rotator preserving posterior approach in primary total hip replacement on early dislocation and clinical outcome.

Three hundred sixty-four primary total hip replacements were divided into two groups based on how the external rotators were treated at surgery. External rotator preservation (Group 1, 165 hips) group was compared with reattachment (Group 2, 199 hips) group by evaluating the clinical and radiographic outcome at one year postoperative. Anteversion was significantly less in Group 1 as compared to Group 2 (P < 0.001). There was no significant difference in inclination between the groups (P > 0.05 in all comparisons). No dislocations were found in 165 hips with external rotator preservation whereas dislocations was noted in 11 (3.9%) in Groups 2, respectively. Group 1 had the higher mean Harris hip score (97.2±2.9 points) as compared with Group 2(94.9±3.4).

The results of this study showed that external rotators could play an important role in preserving joint stability after total hip arthroplasty in patients with osteonecrosis of the femoral head. It can be implied that this modified posterior approach would be able to contribute greatly to prevention of dislocation, and improve clinical outcome after total hip arthroplasty.

There was used cement in first generation total ankle arthroplasty, but first generation of ankle arthroplasty was abandoned because of aseptic loosening of component. For the treatment of aseptic loosening of ankle arthroplasty, there had been many methods. One of methods of revisional ankle arthroplasty is the ankle arthodesis. The authors report a case of revisional ankle arthroplasty using allograft with hybrid external fixation.

45 year old male had surgery of cemented total ankle arthroplasty on his right ankle 20 years ago. He went to our clinics because of motionless and pain of his right ankle. He got the mild pain on his right ankle after 5 years surgery. His pain was managed by oral NSAIDS for 15 years. The pain was aggravated recently. There were osteophytes on posterior aspect of ankle joint and radiolucency around the implant, subtalar arthrosis at the radiograph. There was also sclerosis around the ankle joint.

The authors decided revisional surgery. At the operative findings, we can see the loosening of talar and tibial component and large posterior osteophyte bridging between remained talus and tibial bone. There were no infection signs. After remove the implant, there was big space remained. For the regaining the limb length, we used femoral head allograft. The graft was fixed with 6.5 mm cannulated screws and addition fixed with ilizarov external fixation. Also additional auto bone graft from the osteophytes was applied. Compression over the ilizarov external fixation was done at the end of the operation. Weight bearing was allowed immediate after surgery. Ilizarov ring was removed 6 weeks after surgery. At the 3 months after surgery, bony union was obtained on radiographs.

AOFAS score was improved from 30 to 70 6 mo after surgery. There was no pain on his right ankle. Patient satisfied with arthrodesis with allograft at final follow-up.

The purpose of this study is to compare the two prosthesis which were used for total ankle arthroplasty. From Sept. 2003 to Jun 2007, 13 patients and 14 ankles that could be follow up more than 2 years. Semiconstrained type (Group I, 7cases) and Unconstrained type (Group II, 7cases) were used for total ankle arthroplasty. Mean age was 63.2 year-old, 12 ankles are men and 2 ankles were women. Mean follow up periods were 31.1 months. The criteria to compare the clinical result were postoperative range of motion (ROM), AOFAS foot score and residual bone stock of medial malleolus.

Postoperative ROM of group I was 37.5±7.1 degree and of group II was 51.4±8.9. Postoperative AOFAS score of group I was 76.1±13.8 and of group II was 86.0±5.7. Residual bone stock in medial malleolus of group I was 6.1mm±0.7 and of group II was 11.5mm±0.9. Total number of complication in our study was 9 cases. 3 cases were a malleolar fracture, two occurred at intra-operation, the other at follow-up period. Re-operation was done in 6 cases, 3 cases were calcaneal corrective osteotomy, 2 cases were resection of a heterotopic bone and one case was pedicular flap operation for skin problem.

In our hospital, mobile bearing type prosthesis showed good result than a semiconstrained type in respect of ROM improvement and of residual bone stock in medial malleolus. AOFAS score between two groups showed no definite difference. But small number of patients and short term follow up period is a defect in our study, afterward more population and long term follow up period are needed.

Recently, it has been reported that the posterior stabilised implant clinically used for the total knee replacement (TKR) may have a risk of failures caused by pressure and stress concentrated on the tibial post. Malalignment of the implant or variable loading applied to the implant are one of the major causes of the failure in posteriori stabilised TKR. The purpose of this study is to biomechanically analyse the effect of implant malalignment on the failure risk of the implant in posteriori stabilised TKR by estimating von-Mises stress on the implant.

Finite element models of a knee joint and a posteriori stabilised implant were developed from 1mm slices of CT images and 3D CAD software, respectively. The posterior stabilised implant consists of a femoral component, a tibial post, and a tibial tray. The finite element models of TKR for the neutral alignment case as well as the different malalignment cases (3° and 5° of valgus and varus angulations, 2° and 4° of anterior and posterior tilts, and 3° of external rotation) were developed. Then, the von-Mises stress, which is which was chosen as the fracture risk parameter, acting on the implant were analysed by using CAE software. Loading condition at the 40% of one whole gait cycle such as 2000N of compressive load, 25N of anterior-posterior load, and 6.5Nm of torque was applied to the TKR models.

The maximum von-Mises stresses were concentrated on the anterior region of the tibial post regardless of the oblique loadings. In the rotationally additional loading (3° of external rotation), excessive stresses occurred in the anterior medial and posterior lateral areas. The maximum stress was 18.3MPa in neutral position. The maximum stress increased by 10% in anterior tilt 2°, 15% in anterior tilt 4°, 25% in posterior tilt 2°, 54% in posterior tilt 4°, 116% in varus 3°, 262% in varus 5°, 318% in valgus 3°, 389% in valgus 5°, 6% in external rotation 3° compared with that in the neutral position case. In addition, 32.0MPa of maximum stress occurred on the posterior lateral area of the base component in rotationally additional loading.

The results showed that the implant malalignment could accelerate the stress concentration on the anterior region of the tibial post as in the result of clinical study. In the case of additional rotation, high stress concentration on the anterior medial and posterior lateral areas as well as on the tibial base surface could generate wear or fracture of tibial post. From the additional rotation case, we can expect that higher conformity implant will generate higher stress concentrations than lower conformity implant even though we did not compare the effect of conformity ratio on the stress concentration in the tibial polyethylene component. This study showed that careful consideration of the implant malalignment would be necessary to improve the clinical outcome in the posteriori stabilised TKR.

We developed a modified posterior approach that preserved the short external rotator muscles to prevent dislocation after THA or BHA. The present study aimed to evaluate the effectiveness of short external rotator preserving posterior(ERP) approach for bipolar hemiarthroplasty in treatment of femoral neck fractures in patients with neurologic disorders. Between March 2004 and February 2006, we performed 187 cementless bipolar hemiarthroplasties for displaced femoral neck fractures on 36 patients with neurologic disorders, who were operated on by ERP approach (Group 1) and 151 patients without neurologic deficits, who were operated on by conventional posterolateral approach (Group 2). We compared operation time, the amount of postoperative blood loss, the early postoperative complication rates, the dislocation rate within 1 year, and duration of hospital stay between two groups.

The amount of postoperative blood loss was significantly decreased in group 1(p < 0.01). There were no significant differences in mean operation time and early postoperative complication rate including wound problem, deep vein thrombosis or infection and duration of hospital stay. There was no dislocation after operation in group 1, but seven patient (4.6%) had dislocation in group 2. Nine patients (25.0%) died within postoperative 1 year in group 1 and twenty six patients (17.2%) died in group 2.

Cementless bipolar hemiarthroplasty through ERP approach provides a favorable outcome for treatment of displaced femoral neck fracture in patients with neurologic disorders who is considered as high risk of dislocation. Also, it decreases the postoperative blood loss and the needs of postoperative abduction brace.

The use of stem provides consistent component alignment with immediate stable fixation and protects grafted bone by reducing stress on metaphyseal area in revision total knee arthroplasty. One of major concern with use of stems involves stem tip pain in cementless diaphyseal engaging stem. The purpose of this study is to evaluate the effect of stem design and method of fixation on stem tip pain in revision total knee arthroplasty by finite element analysis.

3D finite element model of normal tibia was reconstructed from CT scan images of 26 year old male and the CAD model of revision total knee arthroplasty was developed using commercial software(CATIA^®, Dassault system, USA, version 8.20). The tibia component models were assembled based on conventional surgical procedure. The design changes of stem such as the length, diameter and slot were performed and methods of fixation including press fit and coefficient of friction was considered. The contact pressure and von-Mises stress around the stem and the micromotion at the interface were evaluated for a 2000 N of external load by finite element analysis to investigate the effect of stem design and methods of fixation on stem tip pain. The longer length and larger diameter press fit stem significantly increase the contact pressure & stress at the end of stem. The distal slot reduces the contact pressure & stress at the end of stem. Less displacement between tibial component and bone was noted in the increased coefficient of friction.

It would be better to avoid using press fit stem with extended length and larger diameter in revision total knee arthroplasty. More flexibility of stem tip would be favorable because of less concentration of stress. Stem fixation with higher coefficient of friction would be recommended for less displacement of tibial component. Stem with shorter length enough to engage proximal diaphysis, closer diameter of proximal canal and minimal press fit could be accepted to reduce stem tip pain if patient’s surgical anatomy such as bone loss and quality is tolerable in revision total knee arthroplasty.

We investigated whether simultaneous bilateral sequential total hip replacement (THR) would increase the rate of mortality and complications compared with unilateral THR in both low- and high-risk groups of patients.

We enrolled 978 patients with bilateral and 1666 with unilateral THR in the study. There were no significant pre-operative differences between the groups in regard to age, gender, body mass index, diagnosis, comorbidity as assessed by the grading of the American Society of Anesthesiologists (ASA), the type of prosthesis and the duration of follow-up. The mean follow-up was for 10.5 years (5 to 13) in the bilateral THR group and 9.8 years (5 to 14) in the unilateral group.

The peri-operative mortality rate of patients who had simultaneous bilateral THR (0.31%, three of 978 patients) was similar to that of patients with unilateral THR (0.18%, three of 1666 patients). The peri-operative mortality rate of patients in the bilateral group was similar in high risk and low risk patients (0.70%, two of 285 patients vs 0.14%, one of 693 patients) and this was also true in the unilateral THR group (0.40%, two of 500 patients vs 0.09%, one of 1166 patients). Patients with bilateral THR required more blood transfusions and a longer hospital stay than those in the unilateral THR group. There was no significant difference (p = 0.32) in the overall number of complications between the groups. This was also true for the low-risk (p = 0.81) vs high-risk (p = 0.631) patients.

Our findings confirm that simultaneous sequential bilateral THR is a safe option for patients who are considered to be either high or low risk according to the ASA classification.

We wished to determine whether simultaneous bilateral sequential total knee replacement (TKR) carried increased rates of mortality and complications compared with unilateral TKR in low- and high-risk patients.

Our study included 2385 patients who had undergone bilateral sequential TKR under one anaesthetic and 719 who had unilateral TKR. There were no significant pre-operative differences between the groups in terms of age, gender, height, weight, body mass index, diagnosis, comorbidity and duration of follow-up, which was a mean of 10.2 years (5 to 14) in the bilateral and 10.4 years (5 to 14) in the unilateral group.

The peri-operative mortality rate (eight patients, 0.3%) of patients who had bilateral sequential TKR was similar to that (five patients, 0.7%) of those undergoing unilateral TKR. In bilateral cases the peri-operative mortality rate (three patients, 0.4%) of patients at high risk was similar to that (five patients, 0.3%) of patients at low risk as it was also in unilateral cases (two patients, 1.0% vs three patients, 0.6%). There was no significant difference (p = 0.735) in either the overall number of major complications between bilateral and unilateral cases or between low- (p = 0.57) and high-risk (p = 0.61) patients. Also, the overall number of minor complications was not significantly different between the bilateral and unilateral group (p = 0.143).

Simultaneous bilateral sequential TKR can be offered to patients at low and high risk and has an expected rate of complications similar to that of unilateral TKR.

The purpose of this study was to determine objectively the outcome of total knee replacement in patients with ankylosed knees.

There were 82 patients (99 knees) with ankylosed knees who underwent total knee replacement with a condylar constrained or a posterior stabilised prosthesis. Their mean age was 41.9 years (23 to 60) and the mean follow-up was for 8.9 years (6.6 to 14). Pre- and post-operative data included the Hospital for Special Surgery (HSS), the Knee Society (KS) and the Western Ontario and McMaster University Osteoarthritis index (WOMAC) scores.

The mean HSS, KS and WOMAC scores improved from 60, 53, and 79 pre-operatively to 81, 85, and 37 at follow-up. These improvements were statistically significant (p = 0.018, 0.001 and 0.014 respectively). The mean physical, social and emotional WOMAC scores also improved significantly (p = 0.032, p = 0.023 and p < 0.001 respectively). The mean satisfaction score was 8.5 (sd 1.5).

Total knee replacement gives good mid-term results in patients with ankylosed knees.

It has been suggested that the wear of ultra-high molecular weight polyethylene (UHMWPE) in total hip replacement is substantially reduced when the femoral head is ceramic rather than metal. However, studies of alumina and zirconia ceramic femoral heads on the penetration of an UHMWPE liner in vivo have given conflicting results.

The purpose of this study was to examine the surface characteristics of 30 alumina and 24 zirconia ceramic femoral heads and to identify any phase transformation in the zirconia heads. We also studied the penetration rate of alumina and zirconia heads into contemporary UHMWPE liners. The alumina heads had been implanted for a mean of 11.3 years (8.1 to 16.2) and zirconia heads for a mean of 9.8 years (7.5 to 15).

The mean surface roughness values of the explanted alumina heads (Ra 40.12 nm and Rpm 578.34 nm) were similar to those for the explanted zirconia heads (Ra 36.21 nm and Rpm 607.34 nm). The mean value of the monoclinic phase of two control zirconia heads was 1% (0.8% to 1.5%) and 1.2% (0.9% to 1.3%), respectively. The mean value of the monoclinic phase of 24 explanted zirconia heads was 7.3% (1% to 26%).

In the alumina group, the mean linear penetration rate of the UMWPE liner was 0.10 mm/yr (0.09 to 0.12) in hips with low Ra and Rpm values (13.22 nm and 85.91 nm, respectively). The mean linear penetration rate of the UHMWPE liner was 0.13 mm/yr (0.07 to 0.23) in hips with high Ra and Rpm values (198.72 nm and 1329 nm, respectively). This difference was significant (p = 0.041).

In the zirconia head group, the mean linear penetration rate of the UHMWPE liner was 0.09 mm/yr (0.07 to 0.14) in hips with low Ra and Rpm values (12.78 nm and 92.99 nm, respectively). The mean linear penetration rate of the UHMWPE liner was 0.12 mm/yr (0.08 to 0.22) in hips with high Ra and Rpm values (199.21 nm and 1381 nm, respectively). This difference was significant (p = 0.039).

The explanted zirconia heads which had a minimal phase transformation had similar surface roughness and a similar penetration rate of UHMWPE liner as the explanted alumina head.

This study reviewed the results of a cementless anatomical femoral component to give immediate post-operative stability, and with a narrow distal section in order not to contact the femoral cortex in the diaphysis, ensuring exclusively metaphyseal loading.

A total of 471 patients (601 hips) who had a total hip replacement between March 1995 and February 2002 were included in the study. There were 297 men and 174 women. The mean age at the time of operation was 52.7 years (28 to 63). Clinical and radiological evaluation were performed at each follow-up. Bone densitometry was carried out on all patients two weeks after operation and at the final follow-up examination. The mean follow-up was 8.8 years (5 to 12).

The mean pre-operative Harris hip score was 41 points (16 to 54), which improved to a mean of 96 (68 to 100) at the final follow-up. No patient complained of thigh pain at any stage. No acetabular or femoral osteolysis was observed and no hip required revision for aseptic loosening of either component. Deep infection occurred in two hips (0.3%) which required revision. One hip (0.2%) required revision of the acetabular component for recurrent dislocation. Bone mineral densitometry revealed a minimal bone loss in the proximal femur.

This cementless anatomical femoral component with metaphyseal loading but without distal fixation produced satisfactory fixation and encourages proximal femoral loading.

We compared the results of 146 patients who received an anatomic modular knee fixed-bearing total knee replacement (TKR) in one knee and a low contact stress rotating platform mobile-bearing TKR in the other. There were 138 women and eight men with a mean age of 69.8 years (42 to 80). The mean follow-up was 13.2 years (11.0 to 14.5). The patients were assessed clinically and radiologically using the rating systems of the Hospital for Special Surgery and the Knee Society at three months, six months, one year, and annually thereafter.

The assessment scores of both rating systems pre-operatively and at the final review did not show any statistically significant differences between the two designs of implant. In the anatomic modular knee group, one knee was revised because of aseptic loosening of the tibial component and one because of infection. In addition, three knees were revised because of wear of the polyethylene tibial bearing. In the low contact stress group, two knees were revised because of instability requiring exchange of the polyethylene insert and one because of infection.

The radiological analysis found no statistical difference in the incidence of radiolucent lines at the final review (Student’s t-test, p = 0.08), most of which occurred at tibial zone 1. The Kaplan-Meier survivorship for aseptic loosening of the anatomic modular knee and the low contact stress implants at 14.5 years was 99% and 100%, respectively, with a 95% confidence interval of 94% to 100% for both designs.

We found no evidence of the superiority of one design over the other at long-term follow-up.

We conducted a randomised prospective study to evaluate the clinical and radiological results of a mobile- and fixed-bearing total knee replacement of similar design in 174 patients who had bilateral simultaneous knee replacement. The mean follow-up was for 5.6 years (5.2 to 6.1).

The total knee score, pain score, functional score and range of movement were not statistically different (p > 0.05) between the two groups. Osteolysis was not seen in any knee in either group. Two knees (1%) in the mobile-bearing group required revision because of infection; none in the fixed-bearing group needed revision. Excellent results can be achieved with both mobile- and fixed-bearing prostheses of similar design at mid-term follow-up. We could demonstrate no significant clinical advantage for a mobile bearing.

We performed a prospective, randomised study to compare the results and rates of complications of primary total knee replacement performed using a quadriceps-sparing technique or a standard arthrotomy in 120 patients who had bilateral total knee replacements carried out under the same anaesthetic. The clinical results, pain scales, surgical and hospital data, post-operative complications and radiological results were compared.

No significant differences were found between the two groups with respect to the blood loss, knee score, function score, pain scale, range of movement or radiological findings. In contrast, the operating time (p = 0.0001) and the tourniquet time (p < 0.0001) were significantly longer in the quadriceps-sparing group, as was the rate of complications (p = 0.0468).

We therefore recommend the use of a standard arthrotomy with the shortest possible skin incision for total knee replacement.

Bilateral sequential total knee replacement was carried out under one anaesthetic in 100 patients. One knee was replaced using a CT-free computer-assisted navigation system and the other conventionally without navigation. The two methods were compared for accuracy of orientation and alignment of the components. There were 85 women and 15 men with a mean age of 67.6 years (54 to 83). Radiological and CT imaging was carried out to determine the alignment of the components. The mean follow-up was 2.3 years (2 to 3).

The operating and tourniquet times were significantly longer in the navigation group (p < 0.001). There were no significant pre- or post-operative differences between the knee scores of the two groups (p = 0.288 and p = 0.429, respectively). The results of imaging and the number of outliers for all radiological parameters were not statistically different (p = 0.109 to p = 0.920).

In this series computer-assisted navigated total knee replacement did not result in more accurate orientation and alignment of the components than that achieved by conventional total knee replacement.

We studied prospectively the long-term results of the Charnley Elite-Plus femoral stem in 184 consecutive young patients (194 hips). There were 130 men and 54 women with a mean age of 49.1 years (21 to 60). The predominant diagnosis was osteonecrosis of the femoral head (63.6%, 117 patients). Clinical and radiological evaluation was undertaken at each follow-up. The mean follow-up was 11.2 years (10 to 12).

The mean pre-operative Harris hip score was 43.4 (12 to 49) which improved to 91 (59 to 100) at the final follow-up. The survival of the femoral stem at 12 years was 99% with revision as the end-point. The mean annual linear wear of the polyethylene liner was 0.17 mm (0.13 to 0.22). The prevalence of acetabular osteolysis was 10.8% (21 hips) and osteolysis of the calcar femorale 12.9% (25 hips).

A third-generation cementing technique, accurate alignment of the stem and the use of a 22 mm zirconia head were important factors in the prevention of aseptic loosening of the Elite Plus femoral stem in these high-risk young patients.

Our aim in this prospective study was to compare the bone mineral density (BMD) around cementless acetabular and femoral components which were identical in geometry and had the same alumina modular femoral head, but differed in regard to the material of the acetabular liners (alumina ceramic or polyethylene) in 50 patients (100 hips) who had undergone bilateral simultaneous primary total hip replacement. Dual energy X-ray absorptiometry scans of the pelvis and proximal femur were obtained at one week, at one year, and annually thereafter during the five-year period of the study.

At the final follow-up, the mean BMD had increased significantly in each group in acetabular zone I of DeLee and Charnley (20% (15% to 26%), p = 0.003), but had decreased in acetabular zone II (24% (18% to 36%) in the alumina group and 25% (17% to 31%) in the polyethylene group, p = 0.001). There was an increase in the mean BMD in zone III of 2% (0.8% to 3.2%) in the alumina group and 1% (0.6% to 2.2%) in the polyethylene group (p = 0.315). There was a decrease in the mean BMD in the calcar region (femoral zone 7) of 15% (8% to 24%) in the alumina group and 14% (6% to 23%) in the polyethylene group (p < 0.001). The mean bone loss in femoral zone 1 of Gruen et al was 2% (1.1% to 3.1%) in the alumina group and 3% (1.3% to 4.3%) in the polyethylene group (p = 0.03), and in femoral zone 6, the mean bone loss was 15% (9% to 27%) in the alumina group and 14% (11% to 29%) in the polyethylene group compared with baseline values. There was an increase in the mean BMD on the final scans in femoral zones 2 (p = 0.04), 3 (p = 0.04), 4 (p = 0.12) and 5 (p = 0.049) in both groups.

There was thus no significant difference in the bone remodelling of the acetabulum and femur five years after total hip replacement in those two groups where the only difference was in the acetabular liner.

Introduction: The purpose of this study was to evaluate the effectiveness of free vascularized fibular grafting (VFG) for the treatment of osteonecrosis of the femoral head.

Materials and Methods: We reviewed the results in a consecutive series of 115 hips (88 patients) who had undergone free VFG between July 1991 and February 1999. Among them, 46 hips (32 patients, 28 males and 4 females) were available with periodic follow-up of at least 5 years. The mean follow up period was 7.1 years (range, 5 to 13 years). An average age of patients was 37.6 years at the time of VFG. We performed survival analysis by the Kaplan-Meier method according to the stage, etiology, age of patients, size of involvement, and degree of collapse of the femoral head. We used the Harris hip score for clinical evaluation, and used plain radiographs and MRIs for radiological evaluation.

Results: The survival rates were 85% in Ficat stage 2a, 34.7% in stage 2b, and 76.2% in stage 3. Eleven hips were evaluated as failures of VFG of which 7 hips were converted to a prosthetic joint. Harris Hip Scores were 67.8 points preoperatively, and increased to 80.4 points postoperatively. Good or excellent results were found in 69.5% of hips clinically and 56.5% of the hips radiologically. Age and size of necrosis affected the postoperative Harris Hip Score significantly, but other factors did not.

Discussion: Free VFG for the early osteonecrosis of femoral head revealed satisfactory results with good survival of the joint and improvements in Harris Hip Scores.

We performed 114 consecutive primary total hip arthroplasties with a cementless expansion acetabular component in 101 patients for advanced osteonecrosis of the femoral head. The mean age of the patients at surgery was 51 years (36 to 62) and the mean length of follow-up was 110 months (84 to 129).

The mean pre-operative Harris hip score of 47 points improved to 93 points at final follow-up. The polyethylene liner was exchanged in two hips during this period and one broken acetabular component was revised. The mean linear wear rate of polyethylene was 0.07 mm/year and peri-acetabular osteolysis was seen in two hips (1.9%). Kaplan-Meier analysis indicated that the survival of the acetabular component without revision was 97.8% (95% confidence interval 0.956 to 1.000) at ten years.

Our study has shown that the results of THA with a cementless expansion acetabular component and an alumina-polyethylene bearing surface are good.

Between January 1984 and January 1986, 131 porous-coated anatomic total hip replacements were performed in 119 consecutive patients. Of these, 100 patients (110 hips) who were alive at a minimum of 18 years after replacement were included in the study. The mean age of the patients at surgery was 48.4 years and that of surviving patients at the latest follow-up was 67.8 years. The mean duration of the clinical and radiological follow-up was 19.4 years (18 to 20).

The mean Harris hip score initially improved from 55 points before to 95 points at two years after operation, but subsequently decreased to 91 points after six years, 87 points after 11.2 years, and 85 points after 19.4 years. At the final follow-up, 23 hips (18%) of the entire cohort and 21% of survivors had undergone revision because of loosening or osteolysis of the acetabular component and eight hips (6%) of the entire cohort and 7% of survivors for loosening or osteolysis of the femoral component. Only four femoral components (4%) were revised for isolated aseptic loosening without osteolysis and two (2%) for recurrent dislocation. On the basis of these long-term results, the porous-coated anatomic femoral component survived for a minimum of 18 years after operation while the acetabular component was less durable. The findings identify the principles of uncemented joint replacement which can be applied to current practice.

We treated eight dysplastic acetabula in six skeletally mature patients with Down’s syndrome by a modified Bernese periacetabular osteotomy. The mean age at the time of surgery was 16.5 years (12.8 to 28.5). Mean length of follow-up was five years (2 to 10.4).

Pre-operatively the mean (Tönnis) acetabular angle was 28°, the centre-edge angle was −9°, and the extrusion index was 60%; post-operatively they were 3°, 37°, and 17%, respectively. Two patients with post-operative (Tönnis) acetabular angles > 10° developed subluxation post-operatively and required secondary varus derotation femoral osteotomies. Another patient developed a late labral tear which was treated arthroscopically. All eight hips remain clinically stable, and are either asymptomatic or symptomatically improved.

These results suggest that the modified Bernese periacetabular osteotomy can be used successfully in the treatment of acetabular dysplasia in patients with Down’s syndrome.

One hundred twenty eight revision hip arthroplasties performed before Dec. 1995 using the Wagner self locking prosthesis were followed for five to ten years. Obviously, the shape of this revision prosthesis complements optimal primary stability; however, one must pay attention not to undersize the stem. Hence, the most significant feature contributing to this self-locking type is the accomplishment of appropriate canal filling when revision with optimum anchorage length of prosthetic component. According to the clinical and radiological data obtained from our midterm results, we confirm the excellent validity of this system for treating the advanced cases of bone resorption for revision. Obviously the classification based on the femoral bone deficiency by the AAOS and DGOT are well documented. Even though we agree with the recent concept of Bourne-Rorabeck that is worthwhile tending to revert to a simple, but practical classification based on the cancellous bone’s quality and the intactness of the cortical tube, we believe that four of Bourne-Rorabeck had better be five in order to be clearer. Furthermore, additional seven various cases series of recent for subsidence of the femoral components were included in this study.

We beieve that the only contraindication is conversion from arthrodesis when the patient has long standing history of heavy plate and screws because of undue discrepancy of the stress shielding. Lastly, it is very unusual, however, we describe the operative technique which Wagner stem is inevitably removed.

The purpose this prospective, randomized clinical trial was to determine if unilateral or bilateral simultaneous total hip arthroplasty procedures resulted in a differing incidence of fat embolization, degree of hemodynamic compromise, levels of hypoxemia or mental status changes. Also, the incidence of fat embolization was compared between the cemented and cementless total hip arthroplasty in the patients with a unilateral- and bilateral simultaneous total hip arthroplasty.

One hundred and fifty-six consecutive patients undergoing primary total hip arthroplasty were enrolled prospectively in the study after giving informed consent. The group consisted of fifty patients undergoing bilateral simultaneous total hip arthroplasty and 106 patients undergoing unilateral total hip arthroplasty. One hundred and three hips were cemented and 103 hips were cementless. To determine the hemodynamic changes and to detect the fat and bone marrow embolization, arterial and right atrial blood samples were obtained before implantation (baseline) and at one, three, five and ten minutes after implantation of the acetabular component. Also, arterial and right atrial blood samples were obtained at one, three, five and ten minutes after implantation of the femoral component. And then blood samples were obtained at twenty-four and forty-eight hours after the operation. Arterial blood pressure, right atrial pressure, arterial oxygen tension and carbon-dioxide tension were monitored at corresponding times. The presence of lipid was determined with oil red O fat stain and the presence of cellular contents of bone marrow was determined with Wright-Giemsa stain.

The incidence of fat embolism was not statistically different (P=1.000) between the patients with a bilateral total hip arthroplasty (twenty seven patients or 54 per cent) and the patients with a unilateral total hip arthroplasty (fifty-two patients or 49 per cent). In the semiquantitative analysis of fat globules in both groups, there was no tendency to have a higher number of fat globules in the bilateral group than in the unilateral group. Also, the incidence of bone marrow embolization was not statistically different (P=0.800) between the patients with a bilateral total hip arthroplasty (eight patients or 16 per cent) and the patients with a unilateral total hip arthroplasty (fourteen patients or 13 per cent). There was no statistical difference (P=0.800) in the incidence of the presence of fat globule between the cemented total hip (thirty-four patients or 34 per cent) and the cementless total hip arthroplasty (forty-seven patients or 44 per cent). Also, there was no statistical difference (P=0.627) in the incidence of the presence of bone marrow cells between the cemented total hip arthroplasty (thirteen patients or 13 per cent) and the cement-less total hip arthroplasty (twelve patients or 11 per cent). Four patients with positive bone marrow cells had neurological manifestation. All of these four patients developed diffuse encephalopathy with confusion and agitation for about twenty-four hours.

The present study confirmed that the incidence of fat and bone marrow embolization is similar in the patients with a bilateral simultaneous-and unilateral total hip arthroplasty as well as in the patients with cemented and cementless total hip arthroplasty. The patients with bone marrow cell emboli had a significantly lower arterial oxygen tension (p=0.022) and oxygen saturation (p=0.017) than the patients without bone marrow cell emboli. On the contrary, the number of fat globules did not affect the perioperative hemodynamic changes. Encephalopathy is related to the biochemical and/or mechanical changes by bone marrow cells.

Introduction: It is very important to evaluate the healing process in the femoral head after free vascularized fibular graft (VFG) in osteonecrosis of the femoral head (ONFH). Bone scintigraphy combined with a pinhole collimator, which is simple and not expensive, is used for very high resolution images of small organs, such as thyroid and certain skeletal regions. The purpose of this study was to assess the changes using pinhole bone scintigraphy in ONFH after VFG.

Materials and Methods: Changes of Tc-99m-HDP pinhole bone scintigraphy were analyzed in 22 cases of ONFH which were treated with VFG and had satisfactory results in patient evaluations at least 2 years after surgery. Harris Hip Scores were 90 points or more; and femoral head collapse was less than 2 mm.

Results: The results were: (1) At 1 week, the pinhole image showed no significant change in cold area but two linear RI uptakes corresponding to the fibular graft were noted. (2) At 3 months, localized hot uptakes just above the tip of the graft were observed in 17 cases (77.2%), and diffuse increased uptake surrounding the cold area were observed. (3) At 6 months, localized hot uptake were increased in size and replaced cold areas and delineated the shape of the superolateral aspect of the femoral head. (4) At 1 year, increased RI uptake of the superolateral aspect of the femoral head expanded medially in all cases. (5) After 2 years, cold areas faded away in 18 cases (81.8%).

Discussion: In conclusion, the authors believe that the Tc-99m-HDP pinhole bone scintigraphy is an excellent method to delineate the healing process in ONFH after VFG.

Introduction: A potential cause of premature loosening of the total hip prosthesis in patients with osteonecrosis is abnormal cancellous bone in the acetabulum and proximal femur. The purpose of this prospective study was to investigate the hypothesis that osteonecrosis is not confined to the femoral head but may extend proximally into acetabulum and distally into the proximal femoral bone. Also, the clinical and radiographic results of total hip arthroplasty with so-called third-generation cementless total hip prostheses were evaluated in sixty-three consecutive patients with osteonecrosis of the femoral head.

Materials and Methods: Twenty-five patients who had simultaneous bilateral total hip arthroplasty, and thirty-eight patients who had a unilateral total hip arthroplasty were included in the study. A cementless acetabular and femoral component were used in all hips. There were fifty-five men and eight women. The mean age at the time of the arthroplasty was 47 years (range, twenty-five to sixty-four years). We performed histological examination of the femoral heads and cancellous bone biopsies from five regions of the hip in patients undergoing total hip arthroplasty. Clinical and radiographic evaluations were performed preoperatively; at six weeks; at three, six, and twelve months; and yearly thereafter. The average duration of follow-up was 4.9 years.

Results: The majority of patients with idiopathic or alcohol induced osteonecrosis had normal bone in the acetabulum and proximal femur. The average Harris hip scores in the group treated with unilateral arthroplasty (96 points) and the group treated with bilateral arthroplasty (94 points) were similar at the time of final follow-up. No component had aseptic loosening. In one hip (1%), an acetabular component and a femoral component were revised because of infection. No hip had detectable wear or osteolysis in the acetabulum or in the proximal femur.

Conclusions: Normal or nearly normal cancellous bone in the acetabulum and proximal femur and advancements in surgical technique and better designs have greatly improved the intermediate-term survival of cementless total hip implants in young patients with osteonecrosis of the femoral head. An absence of osteolysis in these high-risk young patients is partly related to use of ceramic-on-ceramic bearing; solid fixation of the component; and short-term follow-up.

Introduction: The hypothesis that combined necrotic angle measurements using magnetic resonance imaging (MRI) scans predicts the subsequent risk of collapse of femoral head osteonecrosis was tested.

Materials and Methods: Thirty-seven hips with early-stage osteonecrosis in 33 consecutive patients were investigated. The arc of the necrosis was measured by the method of Kerboul et al using mid-coronal and mid-sagittal MRI scans of the femoral head instead of anteroposterior and lateral radiographs, and the two angles were added. Hips were classified into four categories based on the magnitude of the added angle; grade 1 (< 200°), grade 2 (200°–249°), grade 3 (250°–299°), and grade 4 (≥300°). After the initial evaluations, the hips were randomly assigned to a core-decompression group or conservatively-treated group. Patients underwent regular follow-up until femoral head collapse or for a minimum of five years.

Results: Seven hips in the grade 4 category and 16 hips in the grade 3 category developed femoral head collapse in 36 months; six out of nine hips in the grade 2 category, and none of five hips in the grade 1 category developed collapse (log rank test, p< 0.01). In a retrospective analysis, none of the four hips with a combined necrotic angle < 190° (low risk group) collapsed, whereas all 25 hips with a combined necrotic angle > 240° (high risk group) collapsed, and four (50%) of eight hips with a combined necrotic angle between 190° and 240° (moderate risk group) collapsed during the study.

Discussion: The Kerboul combined necrotic angle ascertained by MRI scans instead of radiographs is a major predictor of future collapse.

Introduction: The rate of failure of primary total hip arthroplasty in patients with osteonecrosis of the femoral head is higher than in patients with osteoarthritis. The purpose of this prospective study was to document the clinical and radiographic results of arthroplasty with so-called third generation cementing and the results of second generation cementless total hip arthroplasty in ninety-eight consecutive patients with osteonecrosis of the femoral head.

Materials and Methods: Fifty patients who had simultaneous bilateral total hip arthroplasties with a cemented stem in one hip and a cementless stem in the other and forty-eight patients who had unilateral total hip arthroplasties with a cementless stem were included in the study. A cementless acetabular component was used in all hips. The presumed cause of the osteonecrosis was ethanol abuse in fifty-seven patients, unknown in twenty-seven, fracture of the femoral neck in nine, and steroid use in five. There were eighty men and eighteen women. The mean age the time of the arthroplasty was 47 years (range, twenty-six to fifty-eight years). Clinical and radiographic evaluations were performed preoperatively, at six weeks, at three, six, and twelve months; yearly thereafter. The average duration of follow-up was 9.3 years.

Results: The average Harris hip scores in the group treated with unilateral arthroplasty (97 points) and the group treated with bilateral arthroplasty (94 points) were similar at the time of final follow-up. They were also similar between the group treated with cement (mean, 96 points) and that treated without cement (95 points). No component had aseptic loosening in either group. In one hip, a cemented femoral stem (2 %) and a cementless cup were revised because of infection. Two cementless stems (2%) were revised because of fracture of the proximal part of the femur with loosening of the stem. Annual wear of the polyethylene liner averaged 0.22 mm in the group treated with cement (a zirconia head) and 0.14 mm in the group treated without cement (a cobalt-chrome head). The prevalence of osteolysis in zones 1 and 7 of femur was 16 % in the femur was 16% in the group treated with cement and 24% in the group treated without cement.

Discussion: Advances in surgical technique and better designs have greatly improved the long-term survival of cemented and cementless implants in young patients with osteonecrosis of femoral head. Although there was no aseptic loosening of the components, the high rate of linear wear of the polyethylene liner and high rate of osteolysis in these high risk young patients remain challenging problems.

Introduction: Necrotic fatty marrow is yellow, thick, and turbid like pus and the fat cell is counted as white blood cell in automated cell counting. When necrotic fatty marrow leaks into the hip joint through a crack in the cartilage of the osteonecrotic femoral head, a misdiagnosis of pyogenic infection can be made. The authors report cases of osteonecrosis of the femoral head, in which a misdiagnosis of pyogenic infection was made during the operation.

Materials and Methods: Between September 1997 and December 2001, pyogenic arthritis was suspected during the operation in seven patients who were operated on due to advanced osteonecrosis of the femoral head. The markers of infection including white blood cell count, erythrocyte sedimentation rate, and C reactive protein in preoperative laboratory examination were normal in all of the seven patients. Total hip arthroplasty was scheduled for all patients. When the hip joint capsule was incised, joint fluid gushed out in all patients. The appearance, white blood cell count in automated cell counting, microscopic findings, and the results of culture of the joint fluid were evaluated.

Results: The joint fluid was yellow, thick and turbid like pus. A pyogenic arthritis was suspected and the joint fluid was sent to the laboratory for automated blood cell count, smear and culture. The count of white blood cells ranged from 5800 to 18000 in automated cell counting. No microorganism was identified on joint fluid smear. On microscopic cell counting using a hemocytometer, white blood cells were rarely seen and the majority of cells which were counted as white blood cells, were necrotic fat cell. Total hip arthroplasty was performed immediately after microscopic examination of the joint fluid. No microorganism was identified in cultures of the joint fluid. There was no evidence of infection after total hip arthroplasty at a minimum of two-year followup.

Discussion: When necrotic fatty marrow leaks into the hip joint, the joint fluid looks like pus and white blood cell counts of the joint fluid is increased in automated cell counting because fat cells are counted as white blood cells. In this situation, microscopic examination of the joint fluid is necessary. If the white blood cell count is not increased in microscopic cell counting, replacement arthroplasty can be performed without risk of infection.

Introduction: Some patients with collapsed osteonecrosis of the femoral head do not need any specific treatment because of mild symptoms or disability. The general features of this patient population were evaluated.

Materials and Methods: Forty-five cases of collapsed osteonecrosis of the femoral head in 38 patients were included in this study. These patients visited outpatient clinics for the first time from January 1996 to December 2002. In all cases, pain developed at least 3 years before the last follow-up, but no specific treatment was necessary. There were 27 men and 11 women. The mean age at the onset of pain was 41 years (range, 17 to 72 years). The duration from the onset of pain to the last follow-up was 36 to 167 months (mean, 73 months). The general and radiological features were evaluated.

Results: Risk factors included steroid therapy in 18, alcoholism in 16, other in 1 case; 10 cases had no risk factors (idiopathic). In 29 patients, both femoral heads were involved. Extent of the necrosis was 37 to 89 percent (mean, 62 percent). The amount of depression was 0.5 to 17 mm (mean, 2.2 mm).

Discussion: Steroid therapy was the most frequent risk factor in this patient population. In most cases, the amount of depression was less than 3 mm. Most patients remembered that the pain was most severe at its onset and improved over the next several months.