INTRODUCTION

The restoration of physiological kinematics is one of the goals of a total knee arthroplasty (TKA). Navigation systems have been developed to allow an accurate and precise placement of the implants. But its application to the intraoperative measurement of knee kinematics has not been validated. The hypothesis of this study was that the measurement of the knee axis, femoral rotation, femoral translation with respect to the tibia, and medial and lateral femorotibial gaps during continuous passive knee flexion by the navigation system would be different from that by fluoroscopy taken as reference.

Disorders of human joints manifest during dynamic movement, yet no objective tools are widely available for clinicians to assess or diagnose abnormal joint motion during functional activity. Machine learning tools have supported advances in many applications for image interpretation and understanding and have the potential to enable clinically and economically practical methods for objective assessment of human joint mechanics. We performed a study using convolutional neural networks to autonomously segment radiographic images of knee replacements and to determine the potential for autonomous measurement of knee kinematics. The autonomously segmented images provided superior kinematic measurements for both femur and tibia implant components. We believe this is an encouraging first step towards realization of a completely autonomous capability to accurately quantify dynamic joint motion using a clinically and economically practical methodology.

Background

Scapular notching is a complication after reverse shoulder arthroplasty with a high incidence up to 100%. Its clinical relevance remains uncertain; however, some studies have reported that scapular notching is associated with an inferior clinical outcome. There have been no published articles that studied positional relationship between the scapular neck and polyethylene insert in vivo. The purpose of this study was to measure the distance between the scapular neck and polyethylene insert in shoulders with Grammont type reverse shoulder arthroplasty during active external rotation at the side.

Musculoskeletal modeling techniques simulate reverse total shoulder arthroplasty (RTSA) shoulders and how implant placement affects muscle moment arms. Yet, studies have not taken into account how muscle-length changes affect force-generating capacity postoperatively. We develop a patient-specific model for RTSA patients to predict muscle activation.

Patient-specific muscle parameters were estimated using an optimization scheme calibrating the model to isometric arm abduction data at 0°, 45°, and 90°. We compared predicted muscle activation to experimental electromyography recordings. A twelve-degree of freedom model with experimental measurements created patient-specific data estimating muscle parameters corresponding to strength. Optimization minimized the difference between measured and estimated joint moments and muscle activations, yielding parameters corresponding to subjects' strength that can predict muscle activation and lengths.

Model calibration was performed on RTSA patients' arm abduction data. Predicted muscle activation ranged between 3% and 70% of maximum. The maximum joint moment produced was 10 Nm. The model replicated measured moments accurately (R² > 0.99). The optimized muscle parameters produced feasible muscle moments and activations for dynamic arm abduction when using data from isometric force trials. A normalized correlation was found between predicted and experimental muscle activation for dynamic abduction (r > 0.9); the moment generation to lift the arm was tracked (R² = 0.99).

Statement of Clinical Significance: We developed a framework to predict patient-specific muscle parameters. Combined with patient-specific models incorporating joint configurations, kinematics, and bone anatomy, they can predict muscle activation in novel tasks and, e.g., predict how RTSA implant and surgical decisions may affect muscle function.

Reverse Total shoulder arthroplasty (RTSA) has become an increasingly used solution to treat osteoarthritis and cuff tear arthropathy. Though successful there are still 10 to 65% complication rates reported for RTSA. Complication rates range over different reverse shoulder designs but a clear understanding of implant design parameters that cause complications is still lacking within the literature. In efforts to reduce complication rates (Implant fixation, range of motion, joint stiffness, and fracture) and improve clinical/functional outcomes having to do with proper muscle performance we have employed a computational approach to assess the sensitivity of muscle performance to changes in RTSA implant geometry and surgical placement. The goal of this study was to assess how changes in RTSA joint configuration affect deltoid performance.

An approach was developed from previous work to predict a patient's muscle performance. This approach was automated to assess changes in muscle performance over 1521 joint configurations for an RTSA subject. Patient-specific muscle moment arms, muscle lengths, muscle velocities, and muscle parameters served as inputs into the muscle prediction scheme. We systematically varied joint center locations over 1521 different perturbations from the in vivo measured surgical placement to determine muscle normalized operating region for the anterior, lateral and posterior aspects of the deltoid muscle. The joint center was varied according to previous published work from the RTSA subject's nominal surgical position ±4 mm in the anterior/posterior direction, ±12mm in the medial/lateral direction, and −10 mm to 14 mm in the superior/inferior direction (Walker 2015 et al. Table 2).

Overall muscle normalized operating length varied over 1521 different implant configurations for the RTSA subject. Ideal muscle normalized operating length variations were found to be in all the fundamental directions that the joint was varied. The anterior deltoid normalized operating length was found to be most sensitive with joint configurations changes in the anterior/posterior medial/lateral direction. It lateral deltoid normalized operating length was found to be most sensitive with joint configurations changes in the medial/lateral direction. It posterior deltoid normalized operating length was found to be most sensitive with joint configurations changes in the medial/lateral direction. Reserve actuation for all samples remained below 1 Nm. The most optimal deltoid normalized operating length was implemented by changing the joint configuration in the superior/inferior and medial/lateral directions.

Current shoulder models focus on predicting muscle moment arms. Although valuable it does not allow me for active understanding of how lengthening the muscle will affect its ability to generate force. Our study provides an understanding of how muscle lengthening will affect the force generating capacity of each of the heads of the deltoid. With this information improvements can be made to the surgical placement and design of RTSA to improve functional/clinical outcomes while minimizing complications.

For any figures or tables, please contact the authors directly.

The design of every post-surgical knee arthroplasty study begins with the question “How soon after surgery should we assess the patients?”. The consensus, based primarily upon clinical rating systems, is that patients' scores reach a plateau roughly one year after surgery, and that observations performed at that time should be indicative of the long-term behavior of the joint. This is satisfactory for long-term studies of clinical performance. However, when new devices are introduced there is a need to determine as quickly as possible if the device performs as designed. Waiting a year or more after surgery to characterize a device's performance may place additional patients at risk of receiving an inferior design, or may delay widespread availability of a superior design. The goal of this study was to assess knee arthroplasty patients at 6–12 weeks, 6 months and 1 year after surgery to determine if their tibiofemoral kinematics changed during functional activities.

A total of 13 patients (7 female) were recruited from an ongoing clinical study to participate in this IRB-approved sub-study. All subjects received fixed-bearing, cemented, posterior-cruciate-retaining total knee arthroplasty of the same design from a single surgeon. Subjects averaged 69 years, 169cm tall, and 28 BMI. Subjects were studied at 6–12 weeks, at 6 months and at 12 months post-surgery, when they showed an average clinical flexion of 106°, 113° and 115°, respectively. Subjects' knees were observed using pulsed-flat-panel-fluoroscopy during three activities: lunging to maximum flexion with their foot placed on a 20cm step, kneeling to maximum flexion on a padded bench, and step-up/down on a 20cm step without progression of the contralateral limb. Model-image registration was used to register 3D geometric models of the implants with their radiographic projections based upon measured projection parameters. 3D knee kinematics were derived from the registered models, including joint angles and the antero-posterior translation of the medial and lateral condyles relative to the tibial baseplate.

There were no statistically significant changes in knee kinematics between the 6–12 week and 6 month, and 6-month and 12-month visits during the kneel and lunge activities (Table 1). Similarly, there were no pair-wise differences in tibial rotation or condylar translation during the dynamic step activity at any flexion angle (Figure 1).

Traditional thinking suggests studies of knee mechanics should be performed at least one year after surgery to make observations that are predictive of long-term joint function. In three different functional activities, we could not demonstrate significant changes in knee kinematics between 6–12 weeks and 6 months, nor between 6 months and 12 months. If these results can be confirmed in a larger subject cohort, and for a range of TKA designs, then functional follow-up studies of novel knee arthroplasty designs might be justified as early as 6–12 weeks after surgery, making it possible to accelerate confirmation devices are performing in patients as designed.

For any figures or tables, please contact the authors directly.

Introduction

Current modeling techniques have been used to model the Reverse Total Shoulder Arthroplasty (RTSA) to account for the geometric changes implemented after RTSA [2,3]. Though these models have provided insight into the effects of geometric changes from RTSA these is still a limitation of understanding muscle function after RTSA on a patient-specific basis. The goal of this study sought to overcome this limitation by developing an approach to calibrate patient-specific muscle strength for an RTSA subject.

Reverse Total shoulder arthroplasty (RTSA) has become an increasingly used solution to treat osteoarthritis and cuff tear arthropathy. Though successful there are still 10 to 65% complication rates reported for RTSA. Complication rates range over different reverse shoulder designs but a clear understanding of implant design parameters that cause complications is still lacking within the literature. In efforts to reduce complication rates (Implant fixation, range of motion, joint stiffness, and fracture) and improve clinical/functional outcomes having to do with proper muscle performance we have employed a computational approach to assess the sensitivity of muscle performance to changes in RTSA implant geometry and surgical placement. The goal of this study was to assess how changes in RTSA joint configuration affect deltoid performance.

An approach was developed from previous work to predict a patient's muscle performance. This approach was automated to assess changes in muscle performance over 1521 joint configurations for an RTSA subject. Patient-specific muscle moment arms, muscle lengths, muscle velocities, and muscle parameters served as inputs into the muscle prediction scheme. We systematically varied joint center locations over 1521 different perturbations from the in vivo measured surgical placement to determine muscle activation and normalized operating region for the anterior, lateral and posterior aspects of the deltoid muscle. The joint center was varied from the RTSA subject's nominal surgical position ±4 mm in the anterior/posterior direction, ±12mm in the medial/lateral direction, and −10 mm to 14 mm in the superior/inferior direction.

Overall muscle activity varied over 1521 different implant configurations for the RTSA subject. For initial elevation the RTSA subject showed at least 25% deltoid activation sensitivity in each of the directions of joint configuration change(Figure 1). Posterior deltoid showed a maximal activation variation of 84% in the superior/inferior direction(Figure 1c). Deltoid activation variations lie primarily in the superior/inferior and anterior/posterior directions. An increasing trend was seen for the anterior, lateral and posterior deltoid outside of the discontinuity seen at 28°(Figure 1). Activation variations were compared to subject's experimental data. Reserve actuation for all samples remained below 4Nm(Figure 2). The most optimal deltoid normalized operating length was implemented by changing the joint configuration in the superior/inferior and medial/lateral directions(Figure 3).

Current shoulder models utilize cadaver information in their assessment of generic muscle strength. In adding to this literature we performed a sensitivity study to assess the effects of RTSA joint configurations on deltoid muscle performance in a single patient-specific model. For this patient we were able to assess the best joint configuration to improve the patients muscle function and ideally their clinical outcome. With this information improvements can be made to the surgical placement and design of RTSA on a patient-specific basis to improve functional/clinical outcomes while minimizing complications.

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Total knee arthroplasty (TKA) is an exceptionally successful and robust treatment for disabling knee disease, but many efforts continue to improve patient postoperative satisfaction and performance. One approach to improving performance is to restore TKA motions closer to those in healthy knees. Based upon an idealized model of knee motions, it is possible to design tibiofemoral articulating surfaces to promote natural kinematics and force transfer (Fiedler et al., Acta Bioeng Biomech, 2011). Such an asymmetric design is expected to promote rollback in stance phase that continues through deeply flexed activities. The purpose of this study is twofold: (1) To determine if a TKA designed on a theoretical basis achieves the proposed motions in vivo, and (2) To track postoperative kinematic patterns with examinations at 6–12 weeks, 6 months and one year postoperatively. This paper reports results of the initial cohort that has completed 6–12 week and 6-month examinations.

Eight patients, including 3 females, with unilateral TKA for varus osteoarthritis provided written informed consent prior to beginning the study. Patients averaged 66±9 years, 168±14cm, and 28±3 BMI. Patients performed three weightbearing activities observed using pulsed x-ray flat-panel imaging at 30Hz: stepping up from flexion to extension on a 20cm step, lunging to maximum flexion with the foot placed on a 20 cm step, and kneeling to maximum flexion with the shin placed on a padded support. Three-dimensional knee kinematics were quantified using model-image registration to determine flexion, tibial internal rotation, anteroposterior movement of the femoral condyles (relative to the tibial AP center) and average center of rotation (CoR) in the transverse plane.

During the maximum-flexion lunge and kneeling activities subjects exhibited average knee flexion of 104°–110° and tibial internal rotation of 2°–6° (Table 1). At 6–12 weeks, the medial/lateral condyles were at −3mm/−8mm and −1mm/−6mm during maximum flexion lunge and kneeling, respectively. During the stair activity from 0° to 70° flexion, there were small tibial internal rotations (1°/5°) and anterior medial (2mm/5mm) and lateral (3mm/3mm) condylar translations at both time points (Figure 1). The average CoRs for the stair activity were medial +18% and +5% for the 6–12 week and 6-month exams, respectively.

It has long been assumed knee kinematics change during a patient's first one or two postoperative years. In our early post-op cohort, changes in weight-bearing kinematics over the first 6 postoperative months are small. In maximal flexion activities, patients exhibited flexion similar to similar cohorts studied at least one year post-op (Clin Orthop, 410:131–138, 2003). Similarly, kinematics during the weight-bearing step activity were similar in pattern and magnitude to those previously reported for posterior cruciate-retaining (CR) TKA at least one year post-op (Clin Orthop, 426:187–193, 2004). The average CoRs were medial for the stair activity, which is normal for healthy knees but uncommon for CR TKA. Early post-op results with an asymmetric CR TKA implant intended to promote physiologic motion show flexion and stair kinematics similar to many successful CR designs at longer follow-up. The medial CoR indicates closer-to-physiologic motion than commonly is observed in CR TKA.

Introduction

Reverse total shoulder arthroplasty (RTSA) is a commonly performed operation for a variety of pathologies. Despite excellent short-term outcomes, complications are commonly encountered. Recurrent instability occurs in up to 31% of cases, often due to components placed with too little tension. Acromial stress fractures can occur in up to 7% of cases, often due to components placed in too much tension. Despite these concerns, there is little evidence evaluating the intraoperative tension and glenohumeral contact forces (GHCF) during RTSA. The purpose of this study was to measure the intraoperative GHCF during RTSA.

Intraoperative planning of knee replacement components, targeting a desired functional outcome, requires a calibrated patient-specific model of the patient's soft-tissue anatomy and mechanics. Previously, a surgical technique was demonstrated for measuring knee joint kinematics and kinetics consistent with modern navigation systems in conjunction with the development of a patient-customizable knee model. A data efficient approach for the model calibration task was achieved utilizing the sensitivity of the model to simulated clinical hand manipulations of the knee joint requiring 85% less computations.

For this numerical investigation a simplified knee joint model, based on the OpenKnee repository, consisting of bone (rigid), cruciate ligaments (single-bundle, nonlinear spring), collateral ligaments (multiple nonlinear springs), articular cartilage (rigid, pressure-over-closure relationship), and combined capsule/meniscus (linear springs) was created using a custom Matlab (MathWorks)-Abaqus (Dassault Systèmes) implicit finite element modeling framework (Figure 1). A sensitivity analysis was performed by applying constant loading along the anterior-posterior, medial-lateral, varus-valgus, and internal-external directions (30 N for forces and 3 Nm for moments) while perturbing each customizable parameter positively and negatively by 1 mm at 0, 25, 50, 75 and 100 degrees of flexion. A constant load of 150 N was maintained in compression. The change in static endpoint position was measured relative to the respective position without perturbation. Sensitivity results were then arranged by load direction and principal component analysis was subsequently performed (Table 1).

First a single optimization task was simulated including all model parameters and all loading sequences with the goal of minimizing the kinematic differences between the reference model and a perturbed model (Figure 2). Second, a piecewise optimization task was designed using only the sensitive parameters for a spanning set of loads for the same perturbed model. Parameters 3 and 4 were tuned using internal and external endpoints. Then parameters 1 and 5 were tuned using the anterior endpoints. Similarly, parameters 2 and 7 were tuned using the posterior endpoints. Finally, parameter 8 was tuned using the varus endpoints. All loadings were observed to be insensitive to parameter 6 (ACL-Y). The number of model evaluations required were 2520 and 390 for the single and piecewise optimizations, respectively. The single simulation task recovered all parameters within 0.57 mm on average compared to 0.64 mm on average for the piecewise task. Kinematic errors due to the calibration technique were within 0.001 mm and 0.18 deg compared to 0.001 mm and 0.04 deg.

Computational cost for the optimization task required to calibrate a patient-specific knee model was reduced while maintaining clinically relevant accuracy. This model reduction approach will further enable the rapid adoption of the technology for intraoperative planning of knee replacement components based on targeted functional outcomes.

Modern musculoskeletal modeling techniques have been used to simulate shoulders with reverse total shoulder arthroplasty and study how geometric changes resulting from implant placement affect shoulder muscle moment arms. These studies do not, however, take into account how changes in muscle length will affect the force generating capacity of muscles in their post-operative state. The goal of this study was to develop and calibrate a patient-specific shoulder model for subjects with RTSA in order to predict muscle activation during dynamic activities.

Patient-specific muscle parameters were estimated using a nested optimization scheme calibrating the model to isometric arm abduction data at 0°, 45° and 90°. The model was validated by comparing predicted muscle activation for dynamic abduction to experimental electromyography recordings. A twelve-degree of freedom model was used with experimental measurements to create a set of patient-specific data (three-dimensional kinematics, muscle activations, muscle moment arms, joint moments, muscle lengths, muscle velocities, tendon slack lengths, optimal fiber lengths and peak isometric forces) estimating muscle parameters corresponding to each patient's measured strength. The optimization varied muscle parameters to minimize the difference between measured and estimated joint moments and muscle activations for isometric abduction trials. This optimization yields a set of patient-specific muscle parameters corresponding to the subject's own muscle strength that can be used to predict muscle activation and muscle lengths for a range of dynamic activities.

The model calibration/optimization procedure was performed on arm abduction data for a subject with reverse total shoulder arthroplasty. Muscle activation predicted by the model ranged between 3% and 90% of maximum. The maximum joint moment produced was 20 Nm. The model replicated measured joint moments accurately (R2 > 0.99). The optimized muscle parameter set produced feasible muscle moments and muscle activations for dynamic arm abduction, when calibrated using data from isometric force trials.

Current modeling techniques for the upper extremity focus primarily on geometric changes and their effects on shoulder muscle moment arms. In an effort to create patient-specific models, we have developed a framework to predict subject-specific muscle parameters. These estimated muscle parameters, in combination with patient-specific models that incorporate the patient's joint configurations, kinematics and bone anatomy, provide a framework to predict dynamic muscle activation in novel tasks and, for example, predict how joint center changes with reverse total shoulder arthroplasty may affect muscle function.

Reverse total shoulder arthroplasty (RTSA) is an increasingly common treatment for osteoarthritic shoulders with irreparable rotator cuff tears. Although very successful in alleviating pain and restoring some function, there is little objective information relating geometric changes imposed by the reverse shoulder and arm function, particularly the moment generating capacity of the shoulder muscles. Recent modeling studies of reverse shoulders have shown significant variation in deltoid muscle moment arms over a typical range of humeral offset locations in shoulders with RTSA. The goal of this study was to investigate the sensitivity of muscle moment arms as a function of varying the joint center and humeral offset in three representative RTSA subjects that spanned the anatomical range from our previous study cohort. We hypothesized there may exist a more beneficial joint implant placement, measured by muscle moment arms, compared to the actual surgical implant configuration.

A 12 degree of freedom, subject-specific model was used to represent the shoulders of three patients with RTSA for whom fluoroscopic measurements of scapular and humeral kinematics during abduction had been obtained. The computer model used subject-specific in vivo abduction kinematics and systematically varied humeral offset locations over 1521 different perturbations from the surgical placement to determine moment arms for the anterior, lateral and posterior aspects of the deltoid muscle. The humeral offset was varied from its surgical position ±4 mm in the anterior/posterior direction, ±12mm in the medial/lateral direction, and −10 mm to 14 mm in the superior/inferior direction.

The anterior deltoid moment arm varied up to 20 mm with humeral offset and center of rotation variations, primarily in the medial/lateral and superior/inferior directions. Similarly, the lateral deltoid moment arm demonstrated variations up to 20 mm, primarily with humeral offset changes in the medial/lateral and anterior/posterior directions. The posterior deltoid moment arm varied up to 15mm, primarily in early abduction, and was most sensitive to changes of the humeral offset in the superior/inferior direction.

The goal of this study was to assess the sensitivity of the deltoid muscle moment arms as a function of joint configuration for existing RTSA subjects. High variations were found for all three deltoid components. Variation over the entire abduction arc was greatest in the anterior and lateral deltoid, while the posterior deltoid moment arm was mostly sensitive to humeral offset changes early in the abduction arc. Moment arm changes of 15–20 mm represent a significant amount of the total deltoid moment arm. This means there is an opportunity to dramatically change the deltoid moment arms through surgical placement of the joint center of rotation and humeral stem. Computational models of the shoulder may help surgeons optimize subject-specific placement of RTSA implants to provide the best possible muscle function, and assist implant designers to configure devices for the best overall performance.

Reverse Total shoulder arthroplasty (RTSA) has become an increasingly used solution to treat osteoarthritis and cuff tear arthropathy. Though successful there are still 10 to 65% complication rates reported for RTSA. Complication rates range over different reverse shoulder designs but a clear understanding of implant design parameters that cause complications is still lacking within the literature. In efforts to reduce complication rates (Implant fixation, range of motion, joint stiffness, and fracture) and improve clinical/functional outcomes having to do with proper muscle performance we have employed a computational approach to assess the sensitivity of muscle performance to changes in RTSA implant geometry and surgical placement. The goal of this study was to assess how changes in RTSA joint configuration affect deltoid performance.

An approach was developed from previous work to predict a patient's muscle performance. This approach was automated to assess changes in muscle performance over 1521 joint configurations for an RTSA subject. Patient-specific muscle moment arms, muscle lengths, muscle velocities, and muscle parameters served as inputs into the muscle prediction scheme. We systematically varied joint center locations over 1521 different perturbations from the in vivo measured surgical placement to determine muscle activation and normalized operating region for the anterior, lateral and posterior aspects of the deltoid muscle. The joint center was varied from the RTSA subject's nominal surgical position ±4 mm in the anterior/posterior direction, ±12mm in the medial/lateral direction, and −10 mm to 14 mm in the superior/inferior direction.

Overall muscle activity varied over 1521 different implant configurations for the RTSA subject. For initial elevation the RTSA subject showed at least 25% deltoid activation sensitivity in each of the directions of joint configuration change(Figure 1A–C). Posterior deltoid showed a maximal activation variation of 84% in the superior/inferior direction(Figure 1C). Deltoid activation variations lie primarily in the superior/inferior and anterior/posterior directions(Figure 1). An increasing trend was seen for the anterior, lateral and posterior deltoid outside of the discontinuity seen at 28°(Figur 1A–C). Activation variations were compared to subject's experimental data (Figure 1). Reserve actuation for all samples remained below 4Nm. The most optimal deltoid normalized operating length was implemented by changing the joint configuration in the superior/inferior and medial/lateral directions.

Current shoulder models utilize cadaver information in their assessment of generic muscle strength. In adding to this literature we performed a sensitivity study to assess the effects of RTSA joint configurations on deltoid muscle performance. With this information improvements can be made to the surgical placement and design of RTSA to improve functional/clinical outcomes while minimizing complications.

“How does the knee move?” is a question of fundamental importance for treatment of knee injuries and knee replacement design. Unfortunately, we lack unambiguous and comprehensive knee function data sets and/or consensus on how healthy knees move. One can just as easily find reports stating the natural knee has a center of axial rotation in the medial compartment of the knee as in the lateral. This is due to technical and practical issues: It is extremely difficult to accurately measure knee motions during ambulatory activities and, when that can be done, very few studies have examined a range of weightbearing activities in the same study cohort. The purpose of this study is to report knee kinematics in a cohort of healthy older subjects whose motions were examined during four different movements, three of them weightbearing ambulation, using a high-speed stereoradiographic system.

Six healthy consenting subjects (age = 61 ± 5 years, body mass = 75 ± 8 kg, BMI = 27 ± 4) were observed using a high-speed stereoradiographic system while completing four tasks. Subjects were instructed to perform an unloaded, seated knee extension from high flexion to full extension; to walk at a self selected pace; to step down from a 7 inch platform; and to walk and perform a 90° direction change (pivoting). Stereoradiographic images (1080 × 1080 pixels) were acquired at 100 images/second using 40cm image intensifiers and pulsed x-ray exposures. The three-dimensional knee kinematics were measured using the XROMM software suite (xromm.org, Brown University). Post-processing of the kinematics was performed in custom Matlab programs, and included fitting spheres to the posterior condylar surfaces of each knee, and then tracking the motions of the sphere centers relative to a fixed tibial reference frame (Figure 1). The motions of these flexion-facet centers, were used to determine an average center of axial rotation (CoR) over each activity as previously reported by Banks and Hodge.

Average CoRs for all four activities were in the posterior-medial quadrant of the knee, with the CoR for open-chain knee extension being the most medial and gait the most lateral (Table 1, Figure 2). One-way ANOVA showed average CoRs are different (p « 0.001). There was considerable variation in individual CoRs, for example, with two knees showing lateral CoRs for gait and the remaining knees having medial CoRs.

It should not be surprising that natural knee motions vary with dynamic activity, yet knee kinematics often are presented as being one stereotypic, monolithic pattern of motion. Our data show that the same healthy subjects performing different dynamic activities manifest different knee motions, with open-chain knee extension having the most medial CoR and gait the most lateral. This finding is consistent with previous reports comparing stair climbing and gait in knees with various implant designs. Additional experimental data and, ultimately, validated numerical simulations should facilitate an increasingly accurate process for designing improved treatments for diseased and damaged knees.

Background

Though many advantages of reverse total shoulder arthroplasty (RTSA) have been demonstrated, a variety of complications indicate there is much to learn about how RTSA modifies normal shoulder function. This study assesses how RTSA affects deltoid muscle moment arms post-surgery using a subject-specific computational model driven by in vivo kinematic data.

Introduction

Total knee arthroplasty (TKA) designs evolve as evidence accumulates on natural and prosthetic knee function. TKA designs based upon a medially conforming tibiofemoral articulation seek to reproduce essential aspects of normal knee stability and have enjoyed good clinical success and high patient satisfaction for over two decades. Fluoroscopic kinematic studies on several medially conforming knee designs show extremely stable knee function, but very small ranges of tibial axial rotation compared to healthy knees. The GMK Sphere TKA is a recent evolution in medially-conforming TKA designs that adopts a sagittally unconstrained lateral tibiofemoral articulation to allow more natural tibial rotation. This study was conducted to quantify motions in knees with this prosthesis to address two questions:

Does the medially conforming GMK Sphere design provide an AP-stable articulation that provides for tibiofemoral translations that are comparable to, but not larger than, translations measured in natural knees?

The history of knee mechanics studies and the evolution of knee arthroplasty design have been well reported through the last decade (e.g. [1],[2]). Through the early 2000's, there was near consensus on the dominant motions occurring in the healthy knee among much of the biomechanics and orthopaedic communities. However, the past decade has seen the application of improved measurement techniques to permit accurate measurement of natural knee motion during activities like walking and running. The results of these studies suggest healthy knee motion is more complex than previously thought, and therefore, design of suitable arthroplasty devices more difficult. The purpose of this paper is to briefly review the knee biomechanics literature before 2008, to present newer studies for walking and running, and to discuss the implications of these findings for the design of knee replacement implants that seek to replicate physiologic knee motions.

Many surgeons point to Brantigan and Voshell [3], an anatomic study of over one hundred specimens focusing on the ligamentous and passive stabilizers of the knee, as being an important influence in their thinking about normal knee function. M.A.R. Freeman and colleagues in London claim particular influence from this work, which motivated their extensive series of MR-based knee studies reported in 2000 [4,5,6]. These papers, perhaps more than any others, are responsible for the common impression that knee kinematics are well and simply described as having a ‘medial pivot’ pattern, where the medial condyle remains stationary on the tibial plateau while the lateral condyle translates posteriorly with knee flexion. Indeed, subsequent studies in healthy and arthritic knees during squatting and kneeling [7,8,9] and healthy and ACL-deficient knees during deep knee bends [10,11] show patterns of motion quite similar to those reported by Freeman and coworkers. These studies make a convincing case for how the healthy knee moves during squatting, kneeling and lunging activities. However, these studies are essentially silent on knee motions during ambulatory activities like walking, running and stair-climbing; activities which most agree are critically important to a high-function lifestyle.

In 2008 Koo and Andriacchi reported a motion laboratory study of walking in 46 young healthy individuals and found that the stance phase knee center of rotation was LATERAL in 100% of study participants [12]. One year later, Kozanek et al. published a bi-plane fluoroscopy study of healthy knees walking on a treadmill and corroborated the findings of Koo and Andriacchi, i.e. the center of rotation in healthy knees walking was lateral [13]. Isberg et al. published in 2011 a dynamic radiostereometric study of knee motions in healthy, ACL-deficient and ACL-reconstructed knees during a weight-bearing flexion-to-extension activity, and showed consistent anterior-to-posterior medial condylar translations with knee extension, accompanied by relatively little lateral condylar translation [14]. Hoshino and Tashman reported in 2012 another dynamic radiostereometric analysis of healthy knees during downhill running and concluded “While the location of the knee rotational axis may be dependent on the specific loading condition, during … walking and running … it is positioned primarily on the lateral side of the joint. ”[15] Finally, Claes et al. reported in late 2013 the detailed anatomy of the anterolateral ligament (ALL), another structure serving to stabilize the lateral knee compartment near extension, roughly in parallel with the anterior cruciate ligament (ACL) [16].

Studies since 2008 [9,12–16] show knee motions during walking, running and pivoting activities do not fit the “medial pivot” pattern of motion, but rather point to a “lateral pivot” pattern of knee motion consistent with the stabilizing roles of the ACL and ALL. Having a medial center of rotation in flexion and a lateral center of rotation in extension greatly complicates knee arthroplasty design if the goal is to reproduce kinematics approximating those observed in the natural knee. Consistent kinematics having a fixed center of rotation implies joint stabilizing structures or surfaces, not simply articular laxity allowing the knee to move as forces dictate. Thus, a total knee arthroplasty design seeking to reproduce physiologic motions may need to provide distinct means for controlling tibiofemoral motion in both extension and flexion. Recent studies of natural knee motions have made the implant designer's job more difficult!

Model-image registration types of measurements have profoundly changed capabilities for studying dynamic 3D joint and implant kinematics since their introduction in the early 1990's. Since that time, a variety of proprietary and open-source software packages have been developed and reported for performing these measurements. Model-image registration based measurements have been used to quantify motions in natural and replaced knees, hips, ankles, shoulders, elbows, and spines in both single- and stereo-projection radiographic measurement setups. In theory, with the same quality images and the same quality bone/implant models, any of the software developed to perform model-image registration has the potential to provide equivalent measurement accuracy. Hence, much of the effort to improve measurement capabilities has been to reduce human interaction requirements and make the measurements more automatic and objective. In this paper, we report a new open-source software program that requires a minimum of user input to automate the 3D kinematic measurement process from single- or bi-plane radiographic projections.

JointTrack Auto (JTA) is an open source (sourforge.net/projects/jointtrackauto) program for performing model-image registration of metallic implants with single- or bi-plane radiographic images (see image). A predominantly edge-based cost function is used with an adaptive partioning global optimization scheme for model-image registration. Although this method works without any human intervention, JTA allows users to roughly identify one ‘feature’ of each implant that is visible in all images, e.g. the tip of a peg, to very significantly reduce the search space and time required for numerical optimization. This makes for a very convenient and fast initialization process where a human user simply mouse-clicks on a few easily identifiable locations in each radiographic image, and then the automated registration process is begun.

Registration accuracy examples and a software demonstration will be included in this e-poster presentation to introduce attendees to the software and spur discussion about the various methods available to perform these important measurements.

Reverse total shoulder arthroplasty (RTSA) has had rapidly increasingly utilization since its approval for U.S. use in 2004. RTSA accounted for 11% of extremity market procedure growth in 201. Although RTSA is widely used, there remain significant challenges in determining the location and configuration of implants to achieve optimal clinical and functional results. The goal of this study was to measure the 3D position of the shoulder joint center, relative to the center of the native glenoid face, in 16 subjects with RTSA of three different implant designs, and in 12 healthy young shoulders.

CT scans of 12 healthy and 16 pre-operative shoulders were segmented to create 3D models of the scapula and humerus. A standardized bone coordinate system was defined for each bone (Figure 1). For healthy shoulders, the location of the humeral head center was measured relative to the glenoid face center. For the RTSA shoulders, a two-step measurement was required. First, 3D models of the pre-operative bones were reconstructed and oriented in the same manner as for healthy shoulders. Second, 3D model-image registration was used to determine the post-operative implant positioning relative to the bones. The 3D position and orientation of the implants and bones were determined in a sequence of six fluoroscopic images of the arm during abduction, and the mean implant-to-bone relationships were used to determine the surgical positioning of the implants (Figure 2). The RTSA center of rotation was defined as the offset from the center of the implant glenosphere to the center of the native glenoid face.

The center of rotation in RTSA shoulders varied over a much greater range than the native shoulders (Table 1 (Figure 3)). Lateral offset of the joint center in RTSA shoulders was at least 6 mm smaller than the smallest joint center offset in the healthy shoulders. The center of rotation in RTSA shoulders was significantly more inferior than in healthy shoulders. The range of anterior/posterior placement of the rotation center for RTSA shoulders was bounded by the range for normal shoulders.

How to best position RTSA implants for optimal patient outcomes remains a topic of great debate and research interest. We found that the 3D joint center position can vary over a supraphysiologic range in shoulders with RTSA, and that this variation is primarily in the coronal plane. By relating these geometric variations to muscle, shoulder and clinical function, we hope to establish methods and strategies for predictably obtaining the best clinical and functional outcomes for RTSA patients on a per-subject basis.

Tibial and femoral component malalignment is poorly tolerated in uni- and bi-compartmental knee replacement. Poor outcomes may still occur while using navigation or robotic-assisted bone preparation, which currently require surgeon assessment to establish a preoperative plan for implant placement. Choosing where to place partial knee replacement components is a challenging task that depends on complicated interactions between patient variability and implant design.

We developed a patient-customizable knee model that can assist surgeons by providing a quantitative measure of knee laxity. In order to build upon previous knee modeling efforts and to demonstrate the technique, three-dimensional femur and tibia bone and articular cartilage geometries were obtained from the OpenKnee finite element repository (https://simtk.org/home/openknee). Generic, patient-customizable transversely isotropic, fibril-reinforced cruciate and collateral ligament models, which allow for bone-to-ligament, cartilage-to-ligament, ligament-to-ligament interaction, were substituted into the model (Figure 1). This reduces the dependency on expensive and time-consuming MRI segmentation required to recreate soft-tissue geometries. Ligament pre-tensioning and insertion and origin sites (approximated as elliptical regions fit to the bone surface) can be tuned to match a patient's passive knee kinematics.

The model was run through a series of simulated passive flexion paths. At each degree of flexion, combinations of anterior-posterior and medial-lateral forces as well as internal-external and varus/valgus moments were applied and the resulting joint kinematics were recorded. These results represent the passive envelope of knee motion, which is used to characterize knee laxity. An optimization framework was developed to iteratively tune the cruciate ligament model to match a virtual set of passive loading conditions.

A majority of preoperative planning techniques only monitor geometric targets such as flexion and extension gaps, limb alignment, restoration of the joint line, and tibial component slope. Patient-customized knee models can be tuned to quantify post-operative knee laxity and identify the range of tolerable alignment of partial knee replacement components. Future work will employ in-vitro testing to validate the capability of the model to identify patient-specific cruciate ligament parameters.

Reverse total shoulder arthroplasty (RTSA) is increasingly used in the United States since approval by the FDA in 2003. RTSA relieves pain and restores mobility in arthritic rotator cuff deficient shoulders. Though many advantages of RTSA have been demonstrated, there still are a variety of complications (implant loosening, shoulder impingement, infection, frozen shoulder) making apparent much still is to be learned how RTSA modifies normal shoulder function. The goal of this study was to assess how RTSA affects deltoid muscle moment generating capacity post-surgery using a subject-specific computational model driven by in vivo kinematic data.

A subject-specific 12 degree-of-freedom (DOF) musculoskeletal model was used to analyze the shoulders of 27 subjects (14-RTSA, 12-Normal). The model was modified from the work of Holzbaur et al. to directly input 6 DOF humerus and scapula kinematics obtained using fluoroscopy. Model geometry was scaled according to each subject's skeletal dimensions. In vivo abduction kinematics for each subject were input to their subject-specific model and muscle moment arms for the anterior, lateral and posterior aspects of the deltoid were measured over the arc of motion.

Similar patterns of muscle moment arm changes were observed for normal and RTSA shoulders. The moment arm of the anterior deltoid was positive with the arm at the side and decreased monotonically, crossing zero (the point at which the muscle fibers pass across the joint center) between 50°–60° glenohumeral abduction (Figure 1a). The average moment arm of the lateral deltoid was constant and positive in normal shoulders, but showed a decreasing trend with abduction in RTSA shoulders (Figure 1b). The posterior deltoid moment arm was negative with the arm at the side, and increased monotonically to a positive value with increasing glenohumeral abduction (Figure 1c). Subject-specific moment arm values for RTSA shoulders were highly variable compared to normal shoulders. 2-way repeated measures ANOVA showed significant differences between RTSA and normal shoulders for all three aspects of the deltoid moment arm, where the moment arms in RTSA shoulders were smaller in magnitude.

Shoulder functional capacity is a product of the moment generating ability of the shoulder muscles which, in turn, are a function of the muscle moment arms and muscle forces. Placement of implant components during RTSA can directly affect the geometric relationship between the humerus and scapula and, therefore, the muscle moment arms in the RTSA shoulder. Our results show RTSA shoulders maintain the same muscle moment arm patterns as healthy shoulders, but they show much greater inter-subject variation and smaller moment arm magnitudes. These observations show directly how RTSA configuration and implant placement affect deltoid moment arms, and provide an objective basis for determining optimal implant configuration and surgical placement to maximize RTSA function in a patient-specific manner.

Reverse total shoulder arthroplasty (RTSA) is an increasingly common treatment for osteoarthritic shoulders with irreparable rotator cuff tears. Although very successful in alleviating pain and restoring some function there is little objective information relating geometric changes imposed by the reverse shoulder and the moment generating capacity of the shoulder muscles. Recent modeling studies of reverse shoulders have shown significant variation in deltoid muscle moment arms over varied joint centers for shoulders with RTSA. The goal of this study was to investigate the sensitivity of muscle moment arms as a function of varying the joint center in one representative RTSA subject. We hypothesized there may exist a more beneficial joint implant placement, measured by muscle moment arms, compared to the actual surgical implant placement.

A 12 degree of freedom, subject-specific model was used to represent the shoulder of a patient with RTSA for whom fluoroscopic measurements of scapular and humeral kinematics during abduction had been obtained. The computer model used these abduction kinematics and systematically varied joint center locations over 1521 different perturbations from the surgical placement to determine moment arms for the anterior, lateral and posterior aspects of the deltoid muscle. The joint center was varied from its surgical position ±4 mm in the anterior/posterior direction, 0–24 mm in the medial/lateral direction, and −10 mm to 14 mm in the superior/inferior direction.

The anterior deltoid moment arm varied up to 16mm with center of rotations variations, primarily in the medial/lateral and superior/inferior directions (Figure 2, Table 1(Figure 1)). Similarly, the lateral deltoid moment arm demonstrated variations up to 13 mm, primarily with joint center changes in the anterior/posterior and superior/inferior directions. The posterior deltoid moment arm varied up to 10mm, primarily in early abduction, and was most sensitive to changes of the joint center in demonstrated a sensitivity of 6 mm corresponding to variations in the superior/inferior directions (Figure 2).

The goal of this study was to assess the sensitivity of the deltoid muscle moment arms as a function of joint configuration for an existing RTSA subject. High variations were found for all three deltoid components. Variation over the entire abduction arc was greatest in the anterior and lateral deltoid, while the posterior deltoid moment arm was mostly sensitive to joint center changes early in the abduction arc. Moment arm changes of 10–16mm represent a significant amount of the total deltoid moment arm. This means there is an opportunity to dramatically change the deltoid moments arms through surgical placement of the joint center of rotation. Computational models of the shoulder may help surgeons optimize subject-specific placement of RTSA implants to provide the best possible muscle function, and assist implant designers to configure devices for the best overall performance.

Current modeling techniques have been used to model the Reverse Total Shoulder Arthroplasty (RTSA) to account for the geometric changes implemented after RTSA. Though these models have provided insight into the effects of geometric changes from RTSA these is still a limitation of understanding muscle function after RTSA on a patient-specific basis. The goal of this study sought to overcome this limitation by developing an approach to calibrate patient-specific muscle strength for an RTSA subject.

The approach was performed for both isometric 0° abduction and dynamic abduction. A 12 degree of freedom (DOF) model developed in our previous work was used in conjunction with our clinical data to create a set of patient-specific data (3 dimensional kinematics, muscle activations, muscle moment arms, joint moments, muscle length, muscle velocity, tendon slack length, optimal fiber length, peak isometric force)) that was used in a novel optimization scheme to estimate muscle parameters that correspond to the patient's muscle strength[4]. The optimization varied to minimize the difference between measured(“in vivo”) and predicted joint moments and measured (“in vivo”) and predicted muscle activations. The predicted joint moments were constructed as a summation of muscle moments. The nested optimization was implemented within matlab (Mathworks). The optimization yields a set of muscle parameters that correspond to the subject's muscle strength. The abduction activity was optimized.

The maximum activation for the muscles within the model ranged between .03–2.4 (Figure 1). The maximum joint moment produced was 11 newton-meters. The joint moments were reproduced to an value of 1. Muscle parameters were calculated for both isometric and dynamic abduction (Figure 2). The muscle parameters produced provided a feasible solution to reproduce the joint moments seen “in vivo” (Figure 3).

Current modeling techniques of the upper extremity focus primarily on geometry. In efforts to create patient-specific models we have developed a framework to predict subject-specific strength characteristics. In order to fully understand muscle function we need muscle parameters that correspond to the subject's strength. This effort in conjunction with patient-specific models that incorporate the patient's joint configurations, kinematics and bone anatomy hopes to provide a framework to gain insight into muscle tensioning effects after RTSA. With this framework improvements can be made to the surgical implementation and design of RTSA to improve surgical outcomes.

INTRODUCTION

Total knee arthroplasty (TKA) is one of the most successful and beneficial treatments for osteoarthritic knees. We have developed posterior-stabilized (PS) total knee prosthesis for Asian patients, especially Japanese patients, and have used it since November, 2010. The component was designed based on the CT images of osteoarthritic knees, aiming to achieve deep flexion and stability. The purpose of this study was to analyze in- vivo kinematics of this new prosthesis.

Introduction

Dislocation continues to be a common complication of total hip arthroplasty (THA). Many factors affect the prevalence of dislocation after THA, including soft tissue laxity, surgical approach, component position, patient factors, and component design [1]. Achieving proper intraoperative soft tissue tension is one of the surgical goals to reduce the risk of the dislocation. However, reports of the intraoperative soft tissue tension measurements have not been enough yet. One way to quantify the intraoperative soft tissue tension is to measure joint forces using an instrumented prosthesis. Hence, we have developed a sensor-instrumented modular femoral head of THA to measure the soft-tissue tension intraoperatively. The goal of this study was to design and calibrate the sensor.

Introduction

It is important to measure 2-dimensional (2D) polyethylene wear in total hip arthroplasty (THA) accurately in order to estimate value of wear performance. However, wear vector direction is usually defined in a coordinate system specific manner, which sometimes leads to confusion and makes it difficult to compare measures between techniques. We systematically evaluated the influence of four different coordinate system definitions for the measurement of 2D wear in acetabular cups form radiographs.

Summary

Bi-plane Image matching method is very useful technique to evaluate the loaded 3D motion of each cervical level.

Background:

An upper extremity model of the shoulder was developed from the Stanford upper extremity model (Holzbaur 2005) in this study to assess the muscle lengthening changes that occur as a function of kinematics for reverse total shoulder athroplasty (RTSA). This study assesses muscle moment arm changes as a function of scapulohumeral rhythm (SHR) during abduction for RTSA subjects. The purpose of the study was to calculate the effect of RTSA SHR on the deltoid moment arm over the abduction activity.

Introduction

Cervical orthoses are commonly used to regulate the motion of cervical spines for conservative treatment of injuries and for post-operative immobilization. Previous studies have reported the efficacy of orthoses for 2D flex-extension or 3D motions of the entire cervical spine. However, the ability of cervical orthoses to reduce motion might be different at each intervertebral level and for different types of motion (flexion-extension, rotation, lateral bending). The effectiveness of immobilizing orthoses at each cervical intervertebral level for 3D motions has not been reported. The purpose of this study is to evaluate the effectiveness of the Philadelphia collar to each level of cervical spines with 3D motion analysis under loading condition.

Background

Discrepancies in patient outcomes after total knee arthroplasty have encouraged the development of different treatment options including early preventive interventions. In addition, improvements in surgical techniques and instrumentation have increased the accuracy of the surgeries. In this case study, we review the first robotic-arm assisted modular tricompartmental knee arthroplasty in which bone and soft tissues are conserved by employing a precise planning and execution technique.

Background:

Little is known about scapular kinematics in patients with reverse total shoulder arthroplasty (RTSA). Understanding how RTSA affects shoulder function may help refine its design, use, and rehabilitation strategies. The purpose of this study was to quantify motion in the reverse shoulder. The scapulohumeral rhythm (SHR) of the RTSA shoulder was calculated using 3d-2d image registration techniques. SHR was compared to normal subjects in literature to asses kinematic changes post RTSA.

Introduction

There is great interest in technologies to improve the accuracy and precision in placing implants for total hip arthroplasty (THA). Malik et al. (J Arthroplasty, 2010) showed that an imageless navigation system could be used to produce accurate measures of acetabular cup alignment compared to a CT-based alignment method using an imaging phantom. In this study we sought to compare the precision of an image-based navigation system with post-operative CT scans in a clinical patient cohort who received navigation-assisted THA.

INTRODUCTION

There is strong current interest to provide reliable treatments for one- and two-compartment arthritis in the cruciate-ligament intact knee. An alternative to total knee arthroplasty is to resurface only the diseased compartments with discrete compartmental components. Placing multiple small implants into the knee presents a greater surgical challenge than total knee arthroplasty, and it is not certain natural knee mechanics can be maintained. The goal of this study was to compare functional kinematics in cruciate-intact knees with either medial unicondylar (mUKA), mUKA plus patellofemoral (mUKA+PF), or bi-unicondylar (biUNI) arthroplasty using discrete compartmental implants with preparation and placement assisted by haptic robotic technology.

Introduction

Persistent problems and relatively high complication rates with reverse total shoulder arthroplasty (RTSA) are reported (1, 2). It is assumed that some of these complications are affected by improper intraoperative soft tissue tension. Achieving proper intraoperative soft tissue tension is an obvious surgical goal. However, intraoperative soft tissue tension measurements and methods for RTSA have not been reported. One way to quantify soft tissue tension is to measure intraoperative joint forces using an instrumented prosthesis. Hence, we have developed an instrumented RTSA to measure shoulder joint forces intraoperatively. The goal of this study was to measure intraoperative shoulder joint forces during RTSA.

A unique, laterally stabilized design concept (3D Knee-DJO Surgical, Inc) for total knee arthroplasty (TKA) without traditional post and cam construct was developed to allow surgeons to resurface the arthritic knee while choosing to maintain or sacrifice the posterior cruciate ligament (PCL). Reported complications with current ‘post and cam’ designs of PCL-substituting TKRs include higher polyethylene wear associated with cam-post impingement, increased bone interface shear stresses, and more distal femoral bone resection making revisions more complex and problematic. The effectiveness of this laterally stabilized TKA design has been extensively studied biomechanically using both in-vitro and in-vivo methods. It was hypothesized that for this total knee arthroplasty design; the mid-term clinical, radiographic and functional results would be the same for patients having two different surgical techniques in which the posterior cruciate ligament was either completely retained or completely resected. This study reports on eight year clinical results as well as in-vivo fluoroscopic results and retrieval data. Reported are 159 patients with 116 knees done by a surgeon who preserved the PCL with a bone block technique and 43 knees by a second surgeon who completely resected the PCL. Clinical results did not statistically differ between the two groups and found Knee Society Scores of 96 for Pain and 91 for Function. Average ROM was measured at 124 degrees. Comparative fluoroscopic imaging analysis of in-vivo dynamic flexion activities of thirty-three (20 PCL-preserved and 13 PCL resected) knees was performed demonstrating stable performance and only small (non-significant) mechanical differences. Analysis of two unrelated groups of tibial polyethylene inserts, the first retrieved from patients after 1–4 years in-vivo function (n = 14) and the second after in-vitro knee wear simulation (n = 4) showed low wear rates with no delamination. There was only one failure for mechanical loosening in the cruciate resected group and radiolucent lines of greater than 2 mm were only seen in 4% with none being progressive. Kaplan-Meier Survivorship, using mechanical loosening as the end point, was 99.2% at an average of 8.8 years. In summary, this laterally stabilized TKR design offers a very good alternative to standard ‘post and cam’ PCL sacrificing TKRs while still giving surgeons the ability to maintain the PCL if desired.

Introduction:

Highly cross-linked polyethylene (XLPE) was introduced into clinical practice to decrease acetabular cup wear in total hip arthroplasty (THA) based upon extremely low wear rates in vitro. Numerous short-term clinical studies using XLPE cups have shown promising improvements in wear performance. In this study we evaluated in vivo wear performance of XLPE cups compared to conventional PE (CPE) cups in primary THA at a minimum five years follow-up.

Introduction:

Adjusting joint gaps and establishing mediolateral (ML) soft tissue balance are considered essential interventions for better outcomes in total knee arthroplasty (TKA). However, the relationship between intraoperative laxity measurements and weight-bearing knee kinematics has not been well explored. The goal of this study was to establish how intraoperative joint gaps and ML soft tissue balance affect postoperative kinematics in posterior-stabilized (PS)-TKA.

Background:

Little validation has been done to compare the principle of using the contralateral side as compared to and age and gender matched control. This study seeks to assess the validity of using the contralateral shoulder as the control as opposed to an age- gender- matched control. This study will give insight as to whether the contralateral side is a viable control as compared to a normal age and gender matched control. The study showed that the use of the contralateral shoulder was not a viable normal control.

There is great contemporary interest to provide treatments for knees with medial or medial plus patellofemoral arthritis that allow retention of the cruciate ligaments and the natural lateral compartment. Options for bicompartmental arthroplasty include custom implants, discrete compartmental implants and monoblock off-the-shelf implants. Each approach has potential benefits. The monoblock approach has the potential to provide a cost-efficient off-the-shelf solution with relatively simple surgical instrumentation and procedure. The purpose of this study was to determine if monoblock bicompartmental knee arthroplasty shows evidence of retained cruciate ligament function and clinical performance more similar to unicompartmental arthroplasty than total knee arthroplasty.

Nine females and one male patient were enrolled in this IRB approved study. Each subject received unilateral bicompartmental knee arthroplasty an average of 2.6 years (2.0 to 3.6 years) prior to this study. Subjects averaged 65 years (58–72 years) and 28 BMI (25–31) at the time of surgery. Mean outcome scores at the time of study were 97/95 for the Knee Society knee/function score, 16.4 Oxford score, 6.5 UCLA Activity score and 137 degrees range of motion. Subjects were observed using dynamic fluoroscopy during lunge, kneeling and step-up/down activities. Subjects also received CT scans of the knee in order to create bone/implant composite shape models. Model-image registration techniques were used to determine 3D knee kinematics (Figure 1). Knee angles were quantified using a flexion-abduction-rotation Cardan sequence and condylar translations were determined from the lowest point on the condyle with respect to the transverse plane of the tibial segment.

Maximum knee flexion during lunge and kneeling activities averaged 112°±8° and 125°±7°, respectively. Tibial internal rotation averaged 10°±6° and 12°±10° for the lunge and kneeling activities. For both deeply flexed postures, the medial condyle was 1 mm anterior to the AP center of the tibia while the lateral condyle was 11 mm and 13 mm posterior to the tibial center. For the step-up/down activity, tibial internal rotation increased an average of 2° from 5° to 75° flexion, but was quite variable (Figure 2). Medial condylar translations averaged 4 mm posterior from 5° to 25° flexion, followed by 6 mm anterior translation from 25° to 80° flexion (Figure 3). All knees showed posterior condylar translation from extension to early flexion.

An important potential benefit to any bicompartmental arthroplasty treatments is retention of the cruciate ligaments and maintenance of more natural knee function. The knees in this study showed excellent or good clinical outcomes and functional scores, and relatively activity high levels. There was no evidence of so-called paradoxical anterior femoral translation during early flexion, indicating retained integrity of the natural AP stabilizing structures. Weight-bearing deep flexion during lunge and kneeling activities was comparable to previously reported unicompartmental and well-performing total knee arthroplasty subjects. Kinematics were quite variable between subjects.

Monoblock bicompartmental arthroplasty appears to permit functional retention of the cruciate ligaments, consistent with functionally stable knees. Further efforts should focus on the specific surgical placement of off-the-shelf bicompartmental implants to optimize knee function and provide consistent knee mechanics.

Bi-cruciate substituting total knee arthroplasty (TKA) having two post-cam mechanisms was developed to substitute for cruciate ligament function after surgery. A previous study has shown many of these knees achieve high functional flexion. However, there is little information provided to differentiate between knees able to flex deeply and those that could not, although this is a major concern for surgeons. This study was conducted to compare the kinematic pathway from 0° to 90° in both groups.

Twenty five knees were included in this study. All knees were diagnosed with osteoarthritis (OA) and all TKAs were performed by the same surgeon (WR) from November 2005 to September 2006. A mini mid-vastus surgical approach with posterior cruciate ligament (PCL) resection and patellar resurfacing was used in all cases. Computer navigation was used to guide bone cuts in all the cases. Patients' age averaged 63 years (range, 43–73) at the time of surgery. The study observations were performed at an average of 53 (SD 4) months after surgery. Knee motions were recorded using video-fluoroscopy while subjects performed stair up and down, and lunge activities. The three-dimensional position and orientation of the implant components were determined using model-based shape-matching techniques. This initial manual solution was refined using nonlinear least-squares optimization to maximize image-edge correspondence. Joint kinematics were determined from the three-dimensional pose of each implant component using Cardan/Euler angles. TKAs were divided into two groups according to the maximum lunge angles; TKAs achieved larger than 130° were defined as high flexion group (H group) and the ones from 110° to 130° were defined as moderate flexion group (M group). Tibial internal position and the AP locations of medial and lateral condyles were examined.

Two TKAs were excluded since their maximum flexion was less than 110°. Twelve and eleven TKAs were defined as the H group (High flexing, average 137°, SD 4°) and the M group (Moderate flexing, average 121°, SD 5°), respectively. Tibial internal rotation averaged 10° (SD 4°) and 9° (SD 3°), respectively, at lunge position. The medial and the lateral condyles were located at 9 mm (SD 2 mm) and 17 mm (SD 3 mm) posterior to the tibial centerline during the lunge activity in the M group and at 11 mm (SD 2 mm) and 21 mm (SD 3 mm) in the H group. Tibial rotation was not statistically different (Figure 1), while AP position of the lateral condyle translated more backward in H group at 90° (Figure 2). The TKAs in the M group exhibited femoral forward motion from 0° to 20° flexion, while the H group moved backward (Figure 2).

Our results revealed the post-cam mechanisms worked effectively in the H group TKA. The TKAs which acquired deep flexion successfully prevented the “roll forward motion” and had greater femoral posterior translation at 90° where the posterior post-cam mechanism engages. It appears adequate femoral posterior translation may be important to acquire deep flexion after TKA.

There is great interest to provide repeatable and durable treatments for arthritis localized to one or two compartments in the cruciate-ligament intact knee. We report a series of efforts to develop and characterize an implant system for partial knee resurfacing. We studied distal femoral morphology and found that the sagittal-plane relationships between the condylar and trochlear surfaces are highly variable (Figs 1 and 2). In response, we report the design of a multi-compartmental system of implants intended to anatomically resurface any combination of compartments (Fig 3). Finally, we report the results of a pilot fluoroscopic study of the in vivo knee kinematics in patients who received medial, medial plus patellofemoral and bi-condylar knee arthroplasty. The kinematic results suggest these treatments provide a stable knee with intact cruciate ligament function. This work shows various partial knee resurfacing treatments have the potential to provide excellent knee mechanics and clinical outcomes.

Note - A full paper was submitted for consideration of the Hap Paul Award. The figure legends and numbers in the attached figures correspond to those in the full paper.

INTRODUCTION

Total hip arthroplasty (THA) is regarded as one of the most successful surgeries in medicine. However, recent studies have revealed that ideal acetabular cup implantation is achieved less frequently than previously thought, as little as 50% of the time. It is well known that malalignment of the acetabular component in THA may result in dislocation, reduced range of motion, or accelerated wear. This study reports accuracy of a tactile robotic arm system to ream the acetabulum and impact an acetabulur cup compared to manual instrumentation.

INTRODUCTION

Unicompartmental knee arthroplasty (UKA) can achieve excellent clinical and functional results for patients suffering from single compartment osteoarthritis. However, UKA is considered to be more technically challenging to perform, and malalignment of the implant components has been shown to significantly contribute to UKA failures. The purpose of this investigation was to determine the clinically realized accuracy of UKA component placement using surgical navigation and dynamically referenced tactile-robotics.

Introduction

We introduce the concept of total knee arthroplasty (TKA) fingerprinting as a tool to characterize and graphically convey the sensitivity of a TKA design to surgical variability in implant component position and patient-related anatomic factors. Identifying sensitive directions preoperatively which would cause undesirable effects may decrease revision surgery by informing surgical decisions and planning. To provide several examples of TKA fingerprinting, we estimated and compared the contact forces in a single TKA type for several configurations, simulating surgical variability and patient-related anatomical factors during a loaded deep squat. The purpose of this study is not to analyze the behavior of this specific TKA design but rather to illustrate a tool that could be used to show, in general, how surgical errors or anatomical factors can alter patello-femoral (PF) and tibio-femoral (TF) contact forces compared to its own reference configuration.

Aims

Recently, total knee arthroplasty (TKA) has been generalized as an operation that achieves excellent clinical results. However, younger and Asian patients require even greater implant longevity and functional performance. We hypothesized a novel posterior cruciate-retaining TKA design that restores the anatomical jointline in both sagittal and coronal planes, maintains the femoral posterior condylar offset, and provides low contact stress would provide enhanced patient function with the potential for greater implant longevity.

The performance of total knee arthroplasty in deeply flexed postures is of increasing concern as the procedure is performed on younger, more physically active and more culturally diverse populations. Several implant design factors, including tibiofemoral conformity, tibial slope and posterior condylar geometry have been shown directly to affect deep flexion performance.

The goal of this study was to evaluate the performance of a fixed-bearing, asymmetric, medial rotation arthroplasty design during kneeling activities.

Thirteen study participants (15 knees) with primary total knee arthroplasty (Medial Rotation Knee, Finsbury, Surrey, UK) were observed while doing a step activity and kneeling on a padded bench from 90° to maximum comfortable flexion using lateral fluoroscopy. Subjects averaged 74 years of age and nine were female. Subjects were an average of 17 months post-operative, and scored 94 points on the International Knee Score and 99 on the Functional Score. Digitised fluoroscopic images were corrected for geometric distortion and 3D models of the implant components were registered to determine the 3D position and orientation of the implants in each image.

During the step activity, the medial and the lateral femoral contact point stayed fairly constant with no axial rotation from 0 to 100° of flexion. At maximum kneeling flexion, the knees exhibited 119° of implant flexion (101°-139°), 7° (-7° to 17°) tibial internal rotation, and the lateral condyle translated backwards by 11 mm.

Patients with medial rotation knee arthroplasty exhibited medial pivot action with no paradoxical translation. The knees exhibited excellent kneeling flexion and posterior translation of the femur with respect to the tibia. The axial rotation in MRK was within the range of normal knee kinematics from -10 to 120 (perhaps 140).

Mobile-bearing total knee arthroplasty was developed to provide low contact stress and reasonably unrestricted joint motion. We studied the results of a cementless, posterior cruciate ligament (PCL)-retaining total knee arthroplasty (TKA), with a mobile-bearing insert in rotation and anterior-posterior (AP) translation (Innex^® Anterior-Posterior Glide, Zimmer).

Kinematic analyses were performed on a series of 51 primary TKA. The patients’ mean age was 71±8 years at operation. Patients were studied at 23 months average follow-up with weight-bearing radiographs at full-extension, 30° flexion and maximum flexion (“lunge” position). Three dimensional position and orientation of the mobile-bearing relative to the femoral and the tibial component during flexion were determined using model-based shapematching techniques.

The average weight-bearing range of implant motion was 110°±14°. In flexion, the mobile-bearing was internally rotated 3°±3° with respect to the femoral component (p< 0.0001) and the tibial tray was internally rotated 5°±7° with respect to the mobile-bearing (p< 0.0001). On average, the mobile-bearing did not translate relative to the tibial base plate from full extension to 45° flexion [0±2 mm (range −5 mm to 6 mm)]. However, the mobilebearing did translate anteriorly 1±2 mm (range −2 mm to 9 mm, p< 0.0001) between 45° flexion and maximal flexion.

We conclude that the mobile-bearing insert showed a progressive increase in internal rotation during flexion. Most of this rotational mobility occurred between the mobile insert and the tibial base plate. With flexion, AP translation did occur between the femoral component and mobile-bearing, and between the mobile-bearing and tibial base plate, but mobile-bearing translation was unpredictable with this unconstrained design.

We have performed two-component total ankle arthroplasty (TNK ankle) since 1991 and reported good clinical results. However, in vivo kinematics of this implant are not well understood. The purpose of this study was to measure three-dimensional kinematics of total ankle arthroplasty during non-weightbearing and weightbearing activities.

Forty-seven patients with a mean age of 71 years were enrolled. Preoperative diagnosis was osteoarthritis in 36 patients and rheumatoid arthritis in 11 patients, and the mean followup was 50 months. Radiographs were taken during nonweightbearing maximal dorsiflexion and plantarflexion, and weightbearing maximal dorsiflexion and plantarflexion. Three-dimensional kinematics were determined using 3D-2D model registration techniques. Anatomic coordinate systems were embedded in the tibial and talar implant models, and they were projected onto the radiographic image. Three-dimensional positions and orientations of the implants were determined by matching the silhouette of the models with the silhouette of the image.

From non-weightbearing dorsiflexion to plantarflexion, the talar implant showed 18.1, 0.3, and 1.2 degrees of plantarflexion, inversion, and internal rotation respectively. It also translated 0.8mm posteriorly. There was not significant difference between non-weightbearing and weightbearing kinematics except for the plantarflexion angle (p = 0.007). Posterior hinging, in which tibiotalar contact was seen at only the posterior edge of the talar implant, was observed in 16 patients at either non-weightbearing or weightbearing plantarflexion. There was significantly larger plantarflexion in patients with posterior hinging than patients without hinging (p < 0.001). Nine patients showed anterior hinging at maximum dorsiflexion, and 11 patients showed talar lift-off at maximum plantarflexion.

More than half of the patients showed anterior or posterior edge contact, which might cause excessive contact stress and lead to implant failure in the longer term. This phenomenon is due to the difference in rotation axis between the natural ankle and the implant ankle arthroplasty.

Total knee arthroplasty (TKA) increasingly is utilized to treat younger, more physically active, or more culturally diverse patients who desire the ability to perform activities with high knee flexion. As a result, many implant manufacturers have modified designs or introduced new ones to better facilitate deep knee flexion. To date, a mix of studies has reported superior or equivalent flexion performance comparing high-flexion and traditional implant designs. Importantly, many of these studies are conducted with the patient supine in non-weightbearing postures, not in functional postures where differences in joint mechanics are better manifest. The goal of this study was to evaluate weightbearing kneeling and lunging knee kinematics in patients with bilateral TKA of two types.

Nine high functioning patients from the American Southwest provided informed consent to participate in this single-surgeon study. The subjects averaged 74 years of age and included three females. Each subject received a traditional cruciate-retaining TKA in one knee and a flexion-enhanced cruciate-retaining (7 knees) or posterior-stabilized (2 knees) TKA in the other. The traditional knees were an average of 84 months postoperative and had combined Knee Society Scores averaging 183. The knees with new TKA designs were an average of 31 months postoperative and had combined Knee Society scores averaging 188. Subjects were observed performing a weight-bearing lunge to maximum comfortable flexion and partially weightbearing kneeling to maximum comfortable flexion using lateral fluoroscopy. Model-image registration techniques were used to quantify the 3D translations and rotations of the tibial and femoral components.

There were no differences in maximum knee flexion during lunging (115°±12° versus 118°±7°) or kneeling (120°±14° versus 120°±10°) for the traditional and flex-ionenhanced TKA’s. Tibial internal rotation and abduction were not different. The locations of the medial and lateral condyles were significantly more posterior in the traditional design for both activities (p< 0.05).

This study examined maximum flexion knee kinematics in clinically excellent, high performing subjects with bilateral TKA of two types. No clinically important functional differences were observed. Although flexion-enhanced designs may provide improved flexion for patients who demand it, older patients living a Western lifestyle appear to do equally well with the traditional and flexion-enhanced TKA designs.

Reverse shoulder arthroplasty (RSA) is increasingly utilized to restore shoulder function in patients with osteoarthritis and rotator cuff deficiency. There is currently little known about shoulder function after RSA or if differences in surgical technique or implant design affect shoulder performance. The purpose of this study was to quantify scapulohumeral rhythm in patients with RSA during loaded and unloaded shoulder abduction.

Eleven patients with RSA performed shoulder abduction (elevation and lowering) with and without a handheld 3kg weight during fluoroscopic imaging. Three RSA designs were included. We used model-image registration techniques to determine the 3D position and orientation of the implants. Cubic curves were fit to the humeral elevation as a function of the scapular elevation over the entire motion. The slope of this curve was used to determine the scapulohumeral rhythm (SHR).

For abduction above 40°, shoulders with RSA exhibited an average SHR of 1.5:1.

There was no significant difference in SHR between shoulder abduction with and without 3kg handheld weights (1.6±0.2 unweighted vs. 1.4±0.1 weighted), nor was there a significant difference between elevation and lowering. SHR was highly variable for abduction less than 40°, with SHR ranging from a low of 1 to greater than 10. For these very small groups, there was no apparent pattern of differences between implant designs having differing degrees of lateral offset.

At arm elevation angles less than 40°, SHR in RSA shoulders is highly variable and the mean SHR (2–5) with RSA appears higher than SHR in normal shoulders (2–3).

At higher elevation angles, SHR in shoulders with RSA (1.5–1.8) is much more consistent and appears lower than SHR in normal shoulders (2–4). With the small subject cohort, it was not possible to demonstrate differences between subjects with different implant designs. Ongoing analysis of reverse shoulder function with larger cohort sizes will allow us to refine our observations and determine if there are differences in shoulder function due to implant design, preoperative condition and rehabilitation protocols.

Unicompartmental knee arthroplasty (UKA) is an increasingly attractive and clinically successful treatment for individuals with isolated medial compartment disease who demand high levels of function. A major challenge with UKA is to place the components accurately so they are mechanically harmonious with the retained joint surfaces, ligaments and capsule. Misalignment of UKA components compromises clinical outcomes and implant longevity. Cobb et al. (JBJS-Br 2006) showed that robot-assisted placement of UKA components was more accurate than traditional techniques, and subsequently that the clinical outcomes were improved. Cobb’s method, however, employed rigid intraoperative stabilization of the bones in a stereotactic frame, which is impractical for routine clinical use. Robotic systems have now advanced to include dynamic bone tracking technologies so that rigid fixation is no longer required. The question is -Do these robotic systems with dynamic bone tracking provide the same accuracy advantages demonstrated with robotic systems with rigidly fixed bones? We compared robot-assisted and traditionally instrumented UKA in six bilateral pairs of cadaver specimens. In all knees, a CT-based preoperative plan was performed to determine the ideal positions and orientations for the implant components. Traditional manual instruments were utilized with a tissue-sparing approach to implant one knee of each pair. A haptic robotic system acting as a virtual cutting guide was used to perform the robot-assisted UKA, again with a tissue-sparing approach. Postoperative CT scans were obtained from all knees, and the 3D placement errors were quantified using 3D-to-3D registration of implant and bone models to the reconstructed CT volumes.

The magnitudes of femoral implant orientation error were significantly smaller for the robot-assisted implants compared to traditionally implanted components (4° vs 11°, p< 0.001), but the magnitudes of femoral placement error did not reach significance (3mm vs. 5mm, p=0.056). The magnitudes of tibial implant placement error were not significantly different (4mm vs. 5mm and 7° vs. 7°, p> 0.05).

Well-placed UKA implants can provide durable and excellent functional results, which is an increasingly attractive option for young and active patients with severe compartmental osteoarthritis who wish not to have or to delay a total knee replacement.

Previous studies have demonstrated significant improvement in implant placement accuracy and clinical results with robot-assisted surgery using rigid bone fixation. This study demonstrates it is possible to achieve significant accuracy improvements with robot-assisted techniques allowing free bone movement. Additional larger trials will be required to determine if these differences are realized in clinical populations.

Mobile-bearing total knee replacement (TKR) designs are advocated for their theoretical ability to self-align and accommodate small errors in rotational (axial) alignment. However, for many mobile-bearing TKR, the relationships between axial alignment, knee axial rotation and bearing motion during knee flexion are undefined. This study evaluates whether mobile-bearing TKR with axial alignment outside surgical norms have different rotations and motions compared to well-aligned TKR.

This prospective study included 67 patients implanted with cruciate-retaining mobile-bearing TKR with a rotating platform polyethylene bearing (Scorpio PCS, Stryker). Axial alignment of femoral components relative to the transepicondylar axis and tibial components relative to the medial tibial tuberosity was measured from postoperative CT scans. TKR were categorized as “normal” or “outliers” according to defined tolerances for surgical axial alignment relative to anatomic landmarks (+3° for femur, +10° for tibia) and combined axial mismatch (+5° between femoral and tibial components). Knee kinematics and axial rotation were measured from fluoroscopic images acquired immediately after TKR during 0° to 120° of passive knee flexion. Total knee axial rotation (relative motion between the femoral component and tibial baseplate), femoral component axial rotation on the bearing articular surface, and bearing axial rotation on the tibial baseplate were determined using published shape-matching techniques.

External rotation during knee flexion averaged 8.4°+6.1°, with two phases of axial rotation motion distinguished in all groups. External rotation from 0°–80° occurred primarily due to bearing axial rotation on the tibial baseplate. Beyond 80°, there was combined bearing rotation and external rotation of the femoral component on the polyethylene articular surface, with the latter dominating the motion pattern. Axial rotation varied with the component axial alignment. Among TKR with normal axial alignment, external rotation steadily increased with knee flexion. Among anatomic landmark outliers, there was a transition to internal rotation from 20°–50° and limited (< 1°) axial rotation beyond 80°. Among combined axial mismatch outliers, the magnitude of axial rotation was significantly less than normal TKR throughout the flexion range (p< 0.001) due to opposite rotations between the femoral component and polyethylene bearing.

Achieving appropriate axial alignment using defined bony landmarks remains a challenge. In this study, approximately 30% of TKR did not have suitable axial alignment, with notable combined axial mismatch in tibial-femoral alignment. Axial rotation misalignment affected the kinematics and knee rotation motions over the passive flexion range and appears to result in opposite rotations of the femur-bearing and bearing-base-plate articulations.

Outcomes following TKA often are good, but patients sometimes lack adequate range of motion and strength. Reasons for these deficits may include instability and the loss of cruciate ligament function. One approach to TKA design is to retain the PCL, and configure the TKA surfaces to approximate the function of the ACL. This can be accomplished by having a lateral surface that controls tibiofemoral motion near extension, but allows femoral rollback with flexion. We have been using such a fixed-bearing TKA design since 2001. The purpose of this study was to determine if an ‘ACL-substituting’ arthroplasty design provides clinical and functional results comparable to traditional PCL-retaining arthroplasty designs.

This series consists of 407 consecutive knees in 185 male and 222 female patients (73±9 years, 28±5 BMI) operated from November 2001 to August 2006. All patients underwent TKA by the same surgeon using PCL-retention and implantation of the same cemented ‘ACL-substituting’ TKA design. Clinical outcomes were evaluated using Knee Society Scores and radiographic review for the first 100 TKA with minimum 2 year follow-up. A subset of patients participated in IRB-approved protocols to quantitatively evaluate TKA motion and strength. Functional outcomes were assessed during gait, stair-climbing and curb step-over tasks for 10 unilateral TKA using a motion capture system, force platforms and inverse dynamics to measure the dynamic knee joint flexion moment. Kinematic outcomes were studied during kneeling for 20 TKA using fluoroscopy and shape matching techniques.

Knee Society Scores averaged 96+7 (pain) and 95+12 (function) at an average of 3.2+0.7 (range, 2 to 5) years follow-up. Passive flexion averaged 122°±10°, with 70% of the TKA achieving > 120° flexion. Radiolucent lines (2–4 mm wide) were observed in 7 TKA. Peak flexion moments (dynamic strength) for the TKA averaged 79%, 80% and 85% of the patients’ contralateral normal knees during the gait, stair-climbing and step-over tasks, respectively. In maximum kneeling, knees averaged 131°±13° flexion, 10° ±4° tibial rotation, and 2mm/10mm posterior position of the medial/lateral condyles.

This series’ early clinical follow-up was comparable to any well performing TKA. Knee flexion during passive examination and kneeling were comparable to the best reported results for PCL-retaining and PCL-substituting TKA. Peak knee flexion moments, a measure of functional strength, were comparable to the strongest knees reported in the literature. These early results suggest a fixed-bearing prosthesis with ‘ACL-substitution’ can provide patient performance comparable to the best performing designs.

Kinematics of human joints have been studied using various methods of observation for millennia, including cadaver dissection, mechanical tests, and more recently photogrammetric gait analysis. For just over sixteen years, dynamic single-plane radiographic observations have been used to quantitatively characterize the motions of anatomic and prosthetically replaced joints. These observations have improved the understanding, in particular, of knee function and the influence of prosthetic design and surgical technique on knee kinematics and patient function. Other studies have reported the kinematics of the hip, shoulder, spine and foot/ankle. It is clear that advances in the technologies to acquire and quantify radiographic images of the skeleton in motion can have a major impact on joint mechanics research and, ultimately, clinical diagnosis. This lecture will highlight two avenues of development in our laboratory: open-source software for determining skeletal kinematics from radiographic images, and a novel robotic imaging platform for observing the skeleton in motion.

Our group is working on an open-source shape-matching software application that will be freely available to anyone who wishes to use it (sourceforge.net/projects/jointtrack). This flexible platform will allow the modular addition of new capabilities as plug-in components written in a wide range of languages (C++, Python, Java, etc.), and makes heavy use of other open-source and public libraries (I.C.E., OpenGL, VTK, ITK). All of our future developments will use this platform so that the latest results will be available to all, and hopefully other users will share their advances collaboratively. We currently have created a graphical user interface for performing single-plane model-image registration, and are currently working to expand this to handle bi-plane imaging.

We also are developing a robotic platform to permit radiographic imaging of human joints during normal, unrestricted, dynamic activities. This platform will move the x-ray source and sensor in response to the patient’s unconstrained motion, providing views with greater diagnostic potential than are acquired with fixed or c-arm imaging systems. This same imaging platform will also provide an extremely flexible platform for cone-beam tomography, so that a single system will be able to perform all imaging functions required for skeletal model-image registration based kinematic measurements.

The goal of these endeavors is to advance the possibility that dynamic radiographic analysis of joint motion will soon be a useful, accurate, and routine diagnostic and measurement tool available to enhance the efforts of orthopaedic surgeons in the treatment of their patients.

Posterior-cruciate ligament retaining (CR) total knee arthroplasty (TKA) designs have long been used with excellent clinical success, but have shown kinematics that are significantly different from the natural knee. Recently, variations on traditional CR designs have been introduced. The purpose of this study was to compare deep-flexion knee kinematics in patients with two types of CR-TKA: one group received a traditional non-conforming symmetric articular configuration, and one group received a design incorporating a lateral compartment which is fully congruent in extension, but lax in flexion – approximating the function of the anterior cruciate ligament.

In vivo kinematics were analysed using 3D model registration and plain radiographs of kneeling and squatting activities in 20 TKAs in 18 patients with a minimum follow-up of 12 months. Two surgeons worked together placing all components. Ten knees received a traditional CR-TKA (CR Group), and 10 knees received an ACL-substituting TKA (AS Group). CR Group subjects averaged 66.1±7.4 years and were 12.3±0.5 months post-op. AS Group subjects averaged 68.0±5.4 years and were 12.4±0.7 months post-op. True lateral radiographs were taken in 4 positions:

with the patient in a weight-bearing, single-leg stance,

Two-way repeated measure ANOVA was conducted to determine if there were effects of design or flexion angle on the AP tibiofemoral contact position. Medial and lateral sides were analyzed separately. The level of significance was set at p< 0.05.

There was no significant difference in the average post-operative Knee Society Clinical/Functional Scores between CR Group (96±2/88±11) and AS Group (94±2/92±9). Clinical ROM was recorded using a handheld goniometer. The clinical pre-operative passive ROM was 113 °±15° (80°–135°) for CR Group and 116°±20° (65°–140°) for AS Group (p=0.75). The clinical post-operative passive ROM was 117°±11° (100°–130°) for CR Group and 127°±13° (115°–160°) for AS Group (p=0.07). During squatting, the implant flexion angle was greater for AS Group (119°±15°: 101°–157°) compared to CR Group (104°±10°: 94°–123°, p=0.02). Tibial external rotation at maximum kneeling and squatting activities were significantly larger in AS Group knees (10.2°±4.8°/9.0°±3.9° versus 16.6°±4.1°/15.8°±4.1°, p=0.00/p=0.00). Average tibiofemoral contact position of the lateral condyle during squatting activity was significantly posterior in AS Group compared to CR Group (−11.2±5.6mm vs. −6.2±3.0mm, p=0.02).

Substitution of the ACL by a lateral compartment which is conforming in extension may provide more natural stability and function with knee arthroplasty. In this comparison of two small groups, knees with the ACL-substituting design exhibited femoral AP translation and rotation closer to the natural knee than did knees receiving a traditional symmetric CR prosthesis. The long-term success of TKA depends not only on kinematics factors, such as those reported here, but also on polyethylene wear and patellar complication. A longer-term clinical study will be required to determine if high flexion activity will lead to increase polyethylene wear or patellar complications.

Total knee arthroplasty (TKA) seeks to reduce pain and restore function in patients suffering from degenerative joint disease. TKA has become quite common and does provide predictable pain relief and return to some level of function. However, knees with TKA are not normal knees and do not perform like normal knees, and these facts motivate efforts to improve the functional performance of TKA. In this lecture, we will briefly review observations supporting the perspective that TKA function is strongly influenced by joint mechanics and implant design. In particular, we will discuss data relating joint mechanics and implant design to maximum knee flexion and to functional strength.

A number of studies on various designs of TKA with a range of patient cohorts have identified fairly specific relationships between several aspects of knee mechanics and flexion range. First, posterior translation of the femur with respect to the tibia increases maximum flexion (about 1.4° flexion for each mm of posterior femoral translation). Second, maintaining the natural posterior condylar offset is important to retain or enhance knee flexion (6° flexion are lost for each mm less posterior condylar offset from the natural state). Finally, posterior slope of the tibia can, with some designs, increase the flexion angle before posterior impingement (1.7° more flexion for each addition 1° tibial posterior slope). Various designs can combine these ‘ingredients’ to create unique ‘recipes’ for knee function and flexion. For example, a posterior cruciate ligament (PLC) retaining design can emphasize the second two ingredients, since it is relatively less predictable how the PCL will control anterior-posterior femoral translation. Designs of this type have shown excellent flexion, and significant improvements from past designs. A posterior-cruciate substituting design can emphasize the first ingredient to achieve satisfying flexion. Many other examples can be discussed.

Functional knee strength is another critical element of TKA patient function and also has been studied for decades. In this arena, there seems to be less of a consensus about specific mechanical factors that affect functional knee strength. Posterior femoral translation with respect to the tibia is thought to increase the quadriceps moment arm, and thereby provide greater functional knee strength in demanding tasks. It also has been proposed that the shape of the femoral component can be modified to provide a posterior axis for flexion, which also could increase the quadriceps moment arm. Finally, some argue that joint stability is critical to the normal physiologic co-activation of the quadriceps and hamstrings – where unstable joints recruit greater hamstrings activity and render the quadriceps less functionally effective. Gait laboratory studies are cited to support several of these design paths. Surveys of patient preference give strongest support to the stability hypothesis.

It is clear there is opportunity to improve the function of patients with TKA. By carefully assessing the relationships between patient function and knee arthroplasty mechanics, we can continue evolving TKA designs to better meet the needs of our patients.

Total knee arthroplasty (TKA) has evolved over the past 40 years to a point where it now is a routine treatment with fairly predictable outcomes. However, TKA is an end-stage treatment which frequently is used when only one or two compartments in the knee are damaged. Ideally, treatments for earlier stage and isolated disease would be available to provide the same high level of outcome predictability, but provide for isolated treatment of the affected compartments, greater levels of postoperative physical activity and the shorter convalescence demanded by younger, more active, and often employed patients. One approach to a compartment-by-compartment treatment regime is the utilization of discrete condylar unicompartmental prostheses and a patellofemoral prosthesis in any combination. This approach has been practiced in some European clinics for decades with good reported outcomes. However, it remains a major surgical challenge to optimally place multiple discrete arthroplasty components using conventional tools and small incisions. This lecture will present a detailed overview of a unified approach to minimally invasive, modular knee arthroplasty using haptic robotic instrumentation and implants designed specifically for robotic installation in a customized modular treatment regime.

Haptic robotics provide a ‘virtual cutting guide’ capability permitting precise sculpturing of bone surfaces using near-zero-visibility minimally invasive incisions. The use of a single-multifunctional tool eliminates many of the instrument trays commonly needed for these procedures. The surgeon has complete control in manipulating the bone cutting tool within the desired bone-removal area, but the haptic robotics prohibit the cutting tool from removing bone outside the planned bone removal volume. Precise bone sculpturing has the potential to minimize bone removal and optimize the alignment and fixation of the prosthetic components.

Haptic robotic cutting tools obviously can be used with off-the-shelf prosthetic components, but this approach would fail to fully take advantage of the precision surfaces that can be achieved using robot assisted bone sculpting. Instead, a purpose built system of modular knee components can be defined that work in any combination (medial or lateral unicompartmental, bi-unicondylar, medial or lateral plus patellofemoral, or tricompartmental), require minimum bone removal, can be placed through very small incisions, give great flexibility to customize implant placement to fit the patient’s anatomy, and take advantage of the types of fixation features which easily are created with a robotically controlled bone cutting device.

The current treatment implementation and implant design will be presented. Clinical results for unicompartmental procedures and in vitro results for multiple-compartment procedures will be presented and discussed.

Numerous fluoroscopic studies of total knee arthroplasty (TKA) kinematics have shown that many contemporary TKA designs exhibit abnormal tibiofemoral translations during activities like gait and stair climbing. One reason for these abnormal motions is the absence of the anterior cruciate ligament (ACL) in the vast majority of knees with TKA. The purpose of this study was to analyze knee kinematics during gait and stair activities in patients with a new design of TKA, incorporating a lateral compartment which is fully congruent in extension, but lax in flexion approximating the function of the anterior cruciate ligament. Our goal was to determine if such ACL-substitution results in more normal weight-bearing kinematics during gait and stair activities.

Thirteen ACL-substituting TKAs (AS knees) in 8 patients were observed using fluoroscopy during treadmill gait (1 m/s) and stair stepping. Model-image registration was used to determine the 3D knee kinematics. These kinematics were compared with those from 5 knees with posterior cruciate preserving TKA (PCL Group) and 7 knees with ACL-intact bi-unicondylar arthroplasties (bi-UNI Group). AS Group subjects were 12±6 months post-op. Control groups (PCL Group/bi-UNI Group) subjects were 72±6/15±6 months post-op.

During gait, the AS knees showed 1.6±0.4mm medial condyle posterior translation from heel strike to the middle of stance phase and 2.6±0.3mm posterior translation during swing phase. A similar pattern was observed in the bi-UNI knees. The lateral condyle translated posteriorly 2.1±0.2mm from heel strike to terminal stance phase, similar to the PCL knees and the bi-UNI knees. The center of rotation was predominantly lateral (19% lateral) from heel strike to mid-stance and then moved medially (16% medial) in swing phase. AS knees showed 3.4°±2.4°of internal tibial rotation from mid-stance to terminal stance, similar to the bi-UNI knees. During the stair activity, medial/lateral condylar AP translation in the AS Group was 1.6±0.1mm/2.0±0.3mm from extension to flexion, similar to the bi-UNI knees. The AS knees showed 5.9°±2.4° of internal tibial rotation from 20° to 80° during stair activity, similar to the bi-UNI knees.

Substitution of the ACL by a lateral compartment which is conforming in extension may provide more natural stability and function with knee arthroplasty. Medial condylar translations and axial rotations were similar to those observed in ACL-intact bi-unicondylar knees. Gait kinematics were similar to those reported for healthy natural knees [Koo S and Andriacchi TP, J Biomechancs, 2008]. The long-term success of TKA depends not only on kinematic factors, such as those reported here, but also on polyethylene wear and patellar complications. A longer-term clinical study will be required to determine if ACL-substituting TKA represents an overall functional and clinical improvement compared to more traditional designs.

Cemented total knee arthroplasty has excellent long term survivorship however deficiencies of the cement mantle can compromise results. Minimising mantle deficiencies and increasing mantle size, may improve implant fixation and survivorship. The aim of this study was to evaluate the effectiveness of pressurized carbon dioxide lavage in an attempt to increase cement penetration into bone.

Two consecutive series of TKAs where performed by the senior surgeon. During the first series standard cementing techniques where utilised prior to prosthesis implantation. The bone surfaces were cleaned with pulsatile lavage and then dried prior to cementation (n=69). During the second series a jet of high pressure carbon dioxide was also delivered to the bone surfaces via a hand held device (CarboJet, Kinamed Inc, Global Orthopaedic Technology)(n=50). A single investigator reviewed standardised post operative radiographs with respect to, depth of cement mantle around the prosthesis, and the presence of mantle defects.

The cement mantle around the tibial and femoral prosthesis was divided into multiple zones, similar to that applied by the Knee Society. The depth of cement penetration was then measured for each zone in 0.5 mm increments using a 115% rule. Depths were averaged and then analysed using students’ T test. Cement penetration was greater with the use of pressurized carbon dioxide lavage. The greatest difference was seen in zones 1 and 4 beneath the Tibial prosthesis. A Significant difference was noted between groups.

The size of the cement mantle can be increased with the use of pressurized carbon dioxide lavage. It is postulated that the bone interstices are cleared of fat and fluid more effectively than with fluid lavage alone. This may lead to an improved outcome for cemented total knee arthroplasty.

There is interest to provide total knee arthroplasty (TKA) patients large ranges of functional knee flexion. Factors contributing to flexion include a posterior femoral position on the tibia, posterior condylar offset, and posterior tibial slope. These factors can be incorporated into implant designs and surgical techniques. It is useful to assess the robustness of the resulting design, that is, the consistency of kinematic or functional results when patient and surgical factors vary widely. This study evaluates in vivo flexion performance of a single implant design in patients whose posterior cruciate ligament (PCL) was either retained or sacrificed.

28 knees in 20 patients were imaged using fluoroscopy during maximum flexion kneeling and lunge activities. 20 knees (12 patients) received TKA with the PCL retained by a bone block (PCL+ group). Eight knees (7 patients) received TKA with complete PCL resection (PCL- group). All knees received a fixed-bearing TKA (3D Knee^™, Encore Medical, Austin, TX) with an asymmetric tibial bearing having a sagittally curved medial compartment and a lateral compartment fully congruous with the lateral condyle in extension (approximating anterior cruciate ligament substitution). Three-dimensional knee kinematics were determined using model-based shape registration techniques.

For the kneeling activity, mean implant flexion was 124°±11° for PCL+ knees and 121°±17° for PCL- knees (p> 0.05), mean tibial internal rotation was 10°±4° for PCL+ knees and 9°±3° for PCL- knees (p> 0.05) and tibial valgus was −1°±1° for PCL+ knees and 2°±4° for PCL- knees (p=0.003). Medial contact location averaged −2±4mm and for PCL+ knees and −1±2mm for PCL- knees (p> 0.05). Lateral contact location averaged −10±4mm for PCL+ knees and −7±1mm for PCL- knees (p> 0.05). For the lunge activity, mean implant flexion was 120°±11° for PCL+ knees and 121°±21° for PCL- knees (p> 0.05), mean tibial internal rotation was 11°±4° for PCL+ knees and 8°±3° for PCL- knees (p> 0.05) and tibial valgus was −1°±1° for PCL+ knees and 2°±2° for PCL- knees (p=0.0002). Medial contact location averaged 0±4mm for PCL+ knees and −4±3mm for PCL- knees (p=0.04). Lateral contact location averaged −8±4mm for PCL+ knees and −9±4mm for PCL- knees (p> 0.05).

There was no difference in implant flexion between PCL retaining and sacrificing TKA. Both groups had knees with more than 145° implant flexion (~155° skeletal flexion). There were no significant differences in tibial rotation or lateral condylar contact locations. There were differences in tibial valgus for both activities. PCL- knees exhibited a tendency for the medial compartment to ‘book open’ with flexion beyond 130°, consistent with loss of PCL function. Based on this small cohort comparison, it appears that robust flexion performance and knee kinematics can be obtained with a fixed-bearing TKA design.

Achieving normal strength after total knee arthroplasty (TKA) remains a major challenge, with recent reports suggesting strength following TKA averages 65% of normal. Gait lab studies have reported the greatest strength (80%–84% of normal) in knees with intrinsic stability, i.e. knees where the implant surfaces or retained ligaments provide definitive control of tibiofemoral motions such that dynamic muscle stabilization is not required. Superior results have been reported for bicruciate retaining arthroplasty, posterior-stabilized arthroplasty with early-engaging cams, and single radius highly congruent posterior-stabilized arthroplasty. The goal of this study was to determine if knees with an intrinsically stable posterior cruciate ligament (PCL) retaining implant design showed strength comparable to these other intrinsically stable types of arthroplasty.

Ten patients with unilateral intrinsically stable PCL-retaining knee arthroplasty were studied using full-body motion capture, force platforms and electro myography while they stepped onto and over a 20cm box. The implant design includes an asymmetric tibial bearing surface with a fully congruent lateral articulation (0°–70° flexion). Subjects were recruited on the basis of combined KSS scores greater than 180 one year after surgery. Peak knee flexion torques, normalized by body weight and height, are used as a measure of functional strength.

Knees with posterior cruciate retaining, intrinsically stable TKA exhibit functional strength comparable to other intrinsically stable TKA designs and superior to strength in less stable TKA designs. These knees show some reduction of knee flexor activation, indicating that antagonist coactivation is not required for joint stability. Stable joints permit more optimal muscle activation, making patients effectively stronger while reducing loads at the joint.

Contemporary knee implants use a variety of methods to control tibiofemoral motions. Posterior stabilized implants have a post and cam to force the femur posterior with flexion. Most posterior cruciate retaining designs rely solely on this ligament and symmetric tibial surfaces to control tibiofemoral translations. However, many studies have demonstrated poor control of tibiofemoral motion in PCL retaining knees. One strategy to augmenting PCL function is to provide a gait-congruent lateral articulation providing definitive stability in extension while allowing lateral condylar translation in deep flexion. It is unknown whether this design strategy, essentially substituting for the ACL, allows the PCL to function more normally.

Fifteen knees in ten patients with a fixed-bearing, PCL retaining, lateral pivot arthroplasty were observed during maximum flexion kneeling and lunging using fluoroscopy. The tibial insert provides a fully conforming lateral articulation from 0°–70° flexion, allowing lateral AP translation at greater flexion. Recruited on the basis of combined KSS scores > 180 points, patients averaged 72 years, 27.5 BMI, and 12 months post-op. Shape matching techniques were used to determine the 3D pose of the implant components.

Skeletal flexion during kneeling averaged 134° (117°–156°) with 11° tibial internal rotation. Medial condylar contact was 3mm posterior, and lateral contact was 11 mm posterior to the tibial AP midpoint. Skeletal flexion during lunging averaged 122° (106°–146°) with 11° tibialinternal rotation. Medial condylar contact was 1mm posterior, and lateral condylar contact was 9mm posterior to the tibial AP midpoint.

Knees with lateral pivot arthroplasty exhibited flexion comparable to the best reported results in North American patients. Tibial rotation was statistically greater than has been reported for symmetric posterior stabilized or PCL retaining implants for the same activities. Posterior translation of the condyles with flexion beyond the range of full articular congruity is consistent with relatively normal PCL function.

There is renewed interest in unicondylar knee replacements (UKR) to meet the increasing demand for less invasive surgical procedures for knee arthroplasty. UKR survivorship exceeds 85% at 10 years, with unconstrained (round-on-flat) designs showing significantly better survivorship than conforming designs. However, round-on-flat articulation shave the potential for poor wear performance and more conforming, mobile-bearing UKR designs have been advocated. The purpose of this study was to evaluate the wear performance of unconstrained UKR polyethylene bearings retrieved at revision knee arthroplasty.

Forty-two UKR (eight designs) were retrieved from 26 female and 16 male patients. Patient age averaged 73+10 (45–89) years and time in-situ averaged 7+4 (1–19) years. Revision reasons included loosening (45%), progressive osteoarthritis (17%), polyethylene wear (14%), instability (5%), and other (19%). Retrospective radiographic review of radiolucent lines and component alignment was completed. Polyethylene damage (severity score, 0–3) and location were measured using optical microscopy and digital image analysis.

81% of the polyethylene inserts had a concave deformation located on the central or posterior third of the articular surface, consistent with damage due to femoral component articulation. Abrasive damage on 29 (69%) inserts was consistent with impingement between the polyethylene and extra-articular cement or bone. There was delamination in the central region of 7 (17%) inserts and on the extreme posterior rim of 3 (7%) inserts. Severity score averaged 2.0+1.2 for abrasion and 0.5+1.0 for delamination. Radiographic component position was correlated with abrasive polyethylene damage.

Despite initial tibiofemoral incongruity and concerns of high contact stress, round-on-flat UKR offers a durable knee arthroplasty. Delamination was infrequent and did not correlate with time in-situ. Rather, polyethylene cold flow increased the contact area during in-vivo function. Rigorous attention to cement technique and component position may reduce the incidence of abrasive damage on UKR polyethylene inserts.

Kinematic evaluation of the knee after total joint arthroplasty plays an important role to analyze and understand the post operative outcome of the surgical procedure. The objective of the study was to quantify in vivo kinematics of two different knee designs (dual radius, single radius) by combining video fluoroscopy and helical axis of motion analysis.

3D position of the finite helical axis (FHA) of the displacement of the tibial component of the prosthesis relative the femoral component during a knee extension from 55° to 20° flexion underweight bearing conditions was computed. The motion data were extracted from in vivo fluoroscopy measurement. Angular deviations as angles between each FHA and the mediolateral axis of the femoral component of the prosthesis, and the localization deviation as the distance between each FHA and the center of the femoral component of the prosthesis were calculated. The median and the interquartile range (IQR) of the angular deviation and the localization deviation were computed. Non-parametric Wilcoxon test compared the values of the two designs.

The angular and localization deviations of the dual radius design were bigger than of the single radius design. Median localization deviation, IQR Angle deviation, IQR localization deviation showed highly significant differences between the two designs (p< 0.01).

Compared to the dual radius design the single radius design modified the knee kinematics in vivo. Since it is asingle axis design FHA is therefore concentrated near this unique single axis. On the contrary the dual radius design has two axes, and the FHA floated between these two axes.

There is renewed interest in unicondylar knee replacements (UKR) to meet the increasing demand for less invasive surgical procedures for knee arthroplasty. UKR survivorship exceeds 85% at 10 years, with unconstrained (round-on-flat) designs showing significantly better survivorship than conforming designs. However, round-on-flat articulations have the potential for poor wear performance and more conforming, mobile-bearing UKR designs have been advocated. This study evaluates the wear performance of unconstrained UKR polyethylene bearings retrieved at revision knee arthroplasty.

Forty-two UKR with fixed polyethylene tibial bearings were retrieved. Patient age and time in-situ averaged 73 (45–89) years and 7 (1–19) years, respectively. All knees had intact cruciate ligaments at index surgery. Revision reasons included loosening (45%), progressive arthritis (17%), polyethylene wear (17%), instability (5%), and other (17%). Retrospective radiographic review of radiolucent lines and component alignment was completed using Knee Society guidelines. Polyethylene articular damage size (% of articular surface area), location and damage mode incidence were measured using microscopy and digital image analysis.

Damage area was centrally located and averaged 65%+22%. The largest damage areas consisted of abrasion (19%) and scratching (17%). Revision for loosening or wear was significantly correlated with greater damage area (Spearman Correlation, p=0.049). The incidence of scratching, pitting and abrasion each exceeded 70%, including 29 inserts with peripheral abrasive damage consistent with impingement between the polyethylene and extra-articular cement or bone. Anterior damage location and abrasion were significantly correlated with component position (p< 0.001). Concave surface deformation due to femoral component contact was externally rotated (24 inserts), consistent with tibial external rotation relative to the femoral component, neutrally aligned (11 inserts), internally rotated (4 inserts), and indeterminate (3 inserts).

Despite initial tibiofemoral incongruity and concerns of high contact stress, round-on-flat UKR offers a durable knee arthroplasty. The relatively unconstrained tibiofemoral articulations allowed freedom of placement on the resected bone surfaces and a range of tibio-femoral rotation during activity, as demonstrated by the rotated concave surface deformations. Such deformation may reduce polyethylene contact stresses by increasing the tibio-femoral contact area. However, similar to retrieved mobile bearing UKR which show a 63% incidence of impingement, abrasive damage on these fixed bearing UKR has consequences for polyethylene debris generation and the transmission of shear forces to the bone-implant interface. Rigorous attention to conventional and minimally invasive surgical technique, including cement fixation and component position, is needed to reduce the incidence of abrasive polyethylene damage.

Introduction: Full flexion is a critical performance requirement for patients with total knee replacement (TKR). Different design strategies, such as the post-and-cam, are used to achieve greater femoral rollback during knee flexion. However, substantial damage to the polyethylene tibial post on some posterior cruciate ligament substituting (PS) TKR designs has led to concerns that femoral camtibial post contact will lead to increased insert micromotion and backside wear in modular PS TKR designs. This study evaluated in vivo knee function and polyethylene wear in patients with posterior cruciate ligament retaining (CR) and PS tibial component designs with a full peripheral rim modular locking mechanism.

Methods: Motion Analysis: Thirty two knees with CR (9 knees) and PS (23 knees) tibial inserts participated in fluoroscopic motion analysis during activities of daily living, including stairrise/descent, treadmill gait and maximum kneeling flexion. The metal tibial components used the same full peripheral rim locking mechanism design with the different modular polyethylene articular surfaces. Tibial-femoral contact locations were determined throughout the full range of motion for all activities.

Retrieval Analysis: Polyethylene tibial inserts were retrieved during autopsy and revision surgery after 1 to 74 months. There were 37 CR inserts and 7 PS inserts of the same designs that were evaluated in the motion study. Backside damage on the inserts was assessed on all retrieved inserts using optical microscopy and the damage area and location was measured using digital image analysis.

Results: A relatively posterior position of the femoral component on the tibia was significantly correlated with greater maximum knee flexion. PS TKR had significantly more posterior femoral position and greater maximum flexion than CR TKR. The mean backside damage area was 38%+10% for PS inserts and 45%+15% for CR inserts. Backside surface damage was concentrated near the inserts’ peripheral rim and was dimpled in appearance, consistent with a cast impression of the textured metal baseplate. Scratches and burnishing was infrequently observed. Inserts with the greatest area of backside damage were in-situ for the longest time period.

Discussion: This fluoroscopy-based motion analysis study showed that knees with PS TKR achieve greater maximum flexion than knees with CR TKR. However, retrieved PS inserts did not have larger backside damage areas and the damage pattern location was consistent for both articular geometries. The observed damage morphology suggests that backside damage resulted from axial compression of the polyethylene insert against the textured baseplate rather than micromotion. Previous mechanical tests of this same modular tibial component design have shown that motion between the polyethylene insert and metal baseplate does not increase even after more than six years of in-vivo function.

Introduction: Patellar complications after total knee arthroplasty (TKA) remain a common reason for failure. Fully congruent patellar components, with larger contact areas and a polyethylene articular surface that is free to rotate in the frontal plane (LCS design), were designed to accommodate patellar mechanics and decrease wear. However, it remains to be determined whether the perceived advantages of a mobile-bearing, fully congruent patella design are realized in-vivo. The purpose of this study is correlate wear patterns on congruent mobile-bearing patellar components with patellar mechanics that existed after TKA.

Methods: Uncemented metal-backed patellar components were retrieved at revision surgery from 26 knees with meniscal bearing (23 knees) and rotating platform (3 knees) LCS mobile bearing prostheses (DePuy Orthopaedics). Mean patient age and time in-situ was 75+11 years and 11+4 years, respectively. Revision reasons included bearing wear (11), patella wear (7), instability (2), pain (3), loosening (1), osteolysis (1), and unknown (1). Polyethylene damage was assessed using optical microscopy. Articular wear area was measured using digital image analysis and the % area, location and incidence of each damage mode was calculated.

Results: The average damage area on the retrieved patella occupied 69%+15% of the surface. Burnishing, delamination and scratching modes occupied the largest areas. Delamination was noted on 58% of the retrieved patellae, predominantly located in the superior-medial quadrant. Nine (35%) patellae were fractured, with the fracture plane typically oriented in the medial-lateral direction or along the lateral edge. Twently one (81%) patellae had subsurface cracks oriented along the superior-inferior axis on the extreme lateral edge and along the medial-lateral axis. None of the patellae had embedded third body debris, but the embedded superior metal pin was exposed due to extreme damage in 4 patellas. The original femoral and tibial components were left in-situ in all knees at the time of revision, such that only the polyethylene tibial and patellar articulations were exchanged.

Discussion: Despite severe wear of the components, there was only a 5% incidence of osteolysis noted intra-operatively. Cyclic compressive and tensile forces during knee flexion likely caused initiation and propagation of cracks resulting in patellar bearing fracture. The delami-nation patterns on the retrieved patellae are consistent with bearing rotation into an incongruent bearing position during knee flexion, with presumably high contact stresses occurring in the delaminated superior-medial quadrant. Fully congruent mobile-bearing patella components must maintain mobility between the articular surface and metal back so that areas of incongruent contact, and associated high contact stresses and delamination, do not occur during in-vivo function.

We performed a prospective, randomised trial of 44 patients to compare the functional outcomes of a posterior-cruciate-ligament-retaining and posterior-cruciate-ligament-substituting total knee arthroplasty, and to gain a better understanding of the in vivo kinematic behaviour of both devices.

At follow-up at five years, no statistically significant differences were found in the clinical outcome measurements for either design. The prevalence of radiolucent lines and the survivorship were the same. In a subgroup of 15 knees, additional image-intensifier analysis in the horizontal and sagittal planes was performed during step-up and lunge activity. Our analysis revealed striking differences. Lunge activity showed a mean posterior displacement of both medial and lateral tibiofemoral contact areas (roll-back) which was greater and more consistent in the cruciate-substituting than in the cruciate-retaining group (medial p < 0.0001, lateral p = 0.011). The amount of posterior displacement could predict the maximum flexion which could be achieved (p = 0.018). Forward displacement of the tibiofemoral contact area in flexion during stair activity was seen more in the cruciate-retaining than in the cruciate-substituting group. This was attributed mainly to insufficiency of the posterior cruciate ligament and partially to that of the anterior cruciate ligament. We concluded that, despite similar clinical outcomes, there are significant kinematic differences between cruciate-retaining and cruciate-substituting arthroplasties.

Sagittal knee implant design, together with soft tissue and alignment, determines the kinematics of an artificial knee joint. A single-radius design was thought to improve the kinematics and biomechanics of a knee joint prosthesis and therefore also improve rehabilitation. Two total knee joint prosthesis designs, differing only in their sagittal geometry, were compared in vivo.

To determine the three-dimensional kinematics and difference between a multi-radius and single-radius implants, six patients, all one-year postoperative, were subjected to video-fluoroscopy while walking on a treadmill, stepping up and down a 20-cm step and doing deep lunges.

In a clinical evaluation, differences in range of motion, functional knee score, 40-cm chair raise and anterior pain at 6 weeks and 3, 6 and 12 months were compared in 86 patients with multi-radius and 108 patients with single-radius implants. The age of the patients in the two groups was similar and ranged from 68 to 70 years.

Fluoroscopically-determined flexion was 105° in the multi-radius group and 123° in the single-radius group (p < 0.01). External rotation and lateral condyle movement was statistically similar. The single-radius group did not exhibit paradoxical motion of the medial condyle and had less overall movement. The objective knee scores did not differ significantly (p > 0.05). Patients in the single-radius group gained flexion significantly faster (p < 0.001). After one year, there was no difference between the groups. Three months postoperatively, 72% of the single-radius group could rise from a chair without using their arms, compared to 40% of the multi-radius group (p < 0.001). Although this improved in both groups, it remained superior in the single-radius group. Anterior knee pain was present in 59% of the multi-radius group and in only 18% of the single-radius group at three months (p < 0.001). At one-year follow-up, 4% of the single-radius and 29% of the multi-radius groups respectively complained of anterior knee pain (p < 0.001).

A single-radius sagittal design knee prosthesis leads to faster rehabilitation better and kinematics than a multi-radius design. The reduced movement of the condyles on the polyethylene insert should result in less long-term wear.

Early revision after total knee arthroplasty (TKA) is fortunately uncommon. However, instability and lack of fixation are common early failure mechanisms. Cement techniques utilizing lavage and multiple drill hole interdigitation of the resected tibial surface can reduce micromotion and produce reliable tibial component fixation. This study looks at clinical failure mechanisms, cement technique and polyethylene damage in patients needing early revision of cemented TKA.

PCL-retaining TKA with cement fixation was performed on > 1000 patients at a single institution. Cement techniques varied with surgeon, with some using lavage and drill hole preparation of the resected surface and others electing to cement the surface “as cut”. Seventeen patients were revised within three years of follow-up. Revision reasons included loosening (41%), instability (18%), infection (24%), pain (12%), and malposition (6%). Prospective outcome scores, radiographic data, revision reasons, and polyethylene wear were compared.

Pre-revision pain and function scores gradually decreased back to pre-operative levels. Leg alignment averaged 7° varus (nine patients) and 12° valgus (eight patients) pre-operatively and 5° valgus at pre-revision. Tibial radiolucent lines were present medially only in nine knees and medially and laterally in four knees. The majority of patients revised for loosening had a tibial component cemented onto the “as cut” bone without additional preparation. Damage covered 32%-85% of the polyethylene articular surface. Scratching and pitting were significantly correlated (p< 0.05) with shorter in-situ time and revision for instability and loosening. Alignment and outcome scores were not correlated with damage.

In this series of cemented TKA, loosening and instability accounted for 59% of the early failure, similar to the incidence previously reported for cementless TKA. Cement technique and component positioning, not polyethylene wear, were the primary contributing factors. Attention to ligament balancing and achieving better tibial component fixation is needed to further limit the incidence of early failure after cemented TKA.

The low contact stress and self-aligning properties of mobile bearing total knee replacements (TKR) make them an increasingly popular implant choice worldwide. Two variations on the mobile bearing knee concept have been commonly adopted: systems that retain the posterior cruciate ligament (PCL) and provide free rotation and translation (RT) of the mobile bearing, and systems that sacrifice the PCL and provide for rotation only (RO) motion of the mobile bearing. The purpose of this study was to evaluate the in vivo kinematics of these two types of mobile bearing TKR during gait, stair, and two deep knee flexion activities.

Twelve patients (6 RT, 6 RO) with unilateral mobile bearing knee arthroplasty and excellent functional outcomes at least one year after TKR were studied. Fluoroscopic images of the knee were acquired as patients walked on a treadmill, ascended a step, performed a deep knee bend, and knelt to maximum flexion. Knee kinematics were derived from CAD model based shape matching techniques.

The RT knees exhibited greater posterior translation of the femur on the tibia during early stance in gait (RT: 5mm vs. RO: 2mm) and during knee extension during stair ascent (RT: 5mm vs. RO: 1.5mm). There were no differences between the two groups in the flexion angles achieved during deep knee bend or kneeling.

Although there were no significant clinical or functional differences in these patients, the RO knees exhibited smaller tibio-femoral translations and less intersubject variability in knee kinematics during dynamic weight-bearing activities.

Both backside and articular surface wear have been linked to osteolysis after total knee arthroplasty (TKA). Prostheses with cementless fixation, screw holes in high load regions, and thin polyethylene are susceptible to backside wear. Factors associated with articular wear are similarly well defined. Micromotion at the modular polyethylene interface has been reported for many prostheses, but the relevance of such data compared to articular motions and wear are difficult to appreciate. This study compares in vivo motions and wear occurring at the backside and articular surfaces after TKA.

Contemporary PCL-retaining prostheses from one manufacturer were implanted by one surgeon using cement fixation. The polyethylene inserts were > 6mm thick with a full peripheral rim capture and anterior wire locking mechanism. Femoral condylar motions were measured in 20 knees using fluoroscopic analysis during stair and gait activities. All patients had good to excellent clinical outcomes at one year follow-up. Articular and backside surface damage was evaluated on 32 polyethylene inserts retrieved after 27 months (1 to 71) months in-situ for infection (9), autopsy (6), patellar resurfacing (4), patellar loosening (4), tibial loosening (3), osteolysis (2), and other (4).

Femoral condylar translation over the polyethylene articular surface ranged from 5-10 mm, which is substantially larger than the reported 50-500 micron range of backside interface micromotion measured in vitro. Damage covered < 33% of the backside surface and appeared as a cast impression of the opposed metal tibial component without scratches associated with micromotion. In contrast, damage consisting predominantly of scratching, burnishing and tractive striations covered 46% of the articular surface.

Different locking mechanisms for modular polyethylene inserts result in different degrees of backside wear. No significant backside wear was observed these retrieved inserts with a wire-supplemented peripheral capture. Given the abrasive wear mechanisms and particulate debris shed during femoral condylar sliding, efforts to control motions at the articular surface appear warranted.

How total knee replacements (TKR) articulate is directly related to their functional and wear performance. Recently, significant interest has concerned the center of axial rotation, or pivot point. Since the tibia exhibits internal rotation with knee flexion, the pivot point describes condylar translations: a medial pivot implies posterior lateral condylar translations with flexion, a lateral pivot implies anterior medial condylar translations with flexion.The purpose of this study was to describe the location of the pivot point, as related to TKR design, in a large number of knees studied under dynamic weight-bearing conditions.

Two hundred and four well functioning TKR’s were studied using fluoroscopy as subjects performed a stair ascent. There were 131 cruciate retaining fixed bearing knees (11 designs), 33 mobile bearing knees (5 designs), and 40 posterior stabilized knees (4 designs). CAD model based shape matching was used to determine 3D knee kinematics and the pivot point location from 21,837 images. The pivot location was described as a percentage of tibial width, −50% (lateral) to +50% (medial).

Posterior stabilized knees exhibited medial pivots (mean +14%, +7% to +30%) while cruciate retaining (mean −9%, −35% to +21%) and mobile bearing knees (mean −20%, −48% to +5%) exhibited lateral pivots on average (p< 0.001).

How a TKR design provides A/P stability dictates the location of its center of axial rotation and the A/P motions of the condyles. As the relationship between constraint and in vivo motions becomes clearer, TKR designs can be enhanced to achieve more favorable functional and wear performance.

Validation of input parameters and the resulting polyethylene damage is essential for knee joint wear simulators to be useful in prospective evaluations. The purpose of this study was to compare damage patterns on polyethylene inserts wear tested on a knee simulator with inserts retrieved after well-functioning total knee arthroplasty (TKA).

Five polyethylene tibial inserts from a PCL-retaining knee prosthesis (Natural Knee) were wear tested on an Instron/Stanmore simulator in 50% bovine serum. The input consisted of ISO 14243 force-controlled testing standard to simulate human gait for 5 million cycles. Nine polyethylene tibial inserts (Natural Knee) were retrieved from patients after 52+45 months (13-124) of successful function. The inserts were retrieved post-mortem (n=7) and for pain (n=2). Articular damage was assessed and the circumference of each damage region digitized. The damage size, location and linear surface deformation were measured and the deformation rate (mm/106 cycles or mm/year) was calculated.

The linear deformation rate for all inserts decreased considerably with time. Lateral damage was located significantly more posterior than the medial damage on both the simulated and retrieved inserts, corresponding to femoral external rotation. Retrieved inserts had larger lateral damage, whereas simulator inserts had larger medial damage. The AP extent of damage on the retrieved inserts was significantly greater than the extent on the simulator inserts. Three retrieved inserts had substantial delamination, whereas none of the simulator inserts had delamination.

There was good agreement in the deformation rates for the simulator and retrieved inserts. However, retrieved inserts with delamination show an increased deformation rate and this type of damage did not occur on simulator inserts. The greater AP extent of damage and larger lateral damage on the retrieved inserts suggest that in vitro wear simulation should perhaps include a more complete range of patient activity dynamics to better predict in vivo damage.

The perception that all cemented stems have reasonable assurance of success if implanted with contemporary cement technique has recently been questioned. Surface finish, stem shape, patient weight and high neck offset have been identified as factors contributing to early loosening. Small design changes to existing cemented stems have led to substantial differences in clinical performance. This study investigates the multi-factorial nature of stem loosening after a 24% early failure rate occurred within the initial three years.

Total hip arthroplasty was performed by the same surgeon on 67 patients with an average age and weight of 65 years (21-85) and 82 kg (49-127), respectively. Initial diagnosis was osteoarthritis (84%), osteonecrosis (7%), congenital dysplasia (4%), and other (5%). Modern femoral stems (Perfecta IMC) with increased lateral neck offset were implanted using contemporary cementing techniques. The stems are grit-blasted proximally, with intramedullary collar steps on the anterior/posterior surface. These design features are meant to enhance axial load transfer and stem-cement bonding. All acetabular cups were uncemented and used polyethylene (48 patients) or cobalt-chrome (20 patients) liners. Patients were evaluated with clinical and radiographic follow-up.

Revision for stem loosening was necessary in 16(24%) patients 9 to 38 months after index surgery, including 9 hips revised within the first 18 months. Radiolucencies at the cement/bone interface, stem subsidence and distal femoral osteolysis were consistently observed. Patients with loosening were significantly heavier than those with well-fixed stems (93 kg versus 78 kg, respectively). Revised hips included 7 cobalt-chrome and 9 polyethylene articulations.

It appears that several mechanical factors contributed to these early failures. Lateral offset stems with cement fixation appear to be at risk for loosening in young, heavy patients. Design features and a thin cement mantle may have resulted in increased cement stresses and cracks during the axial and torsional loading that occur with daily activities.

Condylar liftoff can undoubtedly occur with total knee replacements (TKR); it occurs in the surgeon’s hands and has been shown to occur in vivo. However, the reported incidence of condylar liftoff and the implications for articular surface damage require further scrutiny. A three-part argument is made that the incidence of condylar liftoff has been overstated, and there is little direct evidence that condylar liftoff is a significant factor in the wear performance of coronally flat-on-flat TKR’s. First, an analysis of fluoroscopic measurement errors based on the uncertainty in measuring varus/valgus angles (the parameter used to determine liftoff) reveals that the standard error for liftoff measurements is 1.2mm, nearly identical to the mean liftoff value in recent published reports. Second, because most TKR’s have some anterior/posterior curvature of the tibial insert, any axial rotation of the knee induces a varus/valgus angulation that can be interpreted as liftoff, even though the condyles remain in contact. Third, condylar liftouff has been used to justify the need for coronally round-on-round geometries, yet an analysis of 100 unselected retrieved tibial inserts from three coronally flat designs reveals no difference in wear type, magnitude, severity, depth, or symmetry between the medial and lateral aspects of the tibial inserts. Although condylar liftoff certainly can occur in vivo, an argument can be made that the incidence of liftoff in experimental studies has been overstated, and that there is little evidence from retrievals that contemporary coronally flat-on-flat TKR’s are uniquely susceptible to articular damage from condylar liftoff.

The role of the posterior cruciate ligament (PCL) after total knee arthroplasty has been controversial. Previous studies have reported that function of the preserved PCL after TKA was questionable and that it was difficult to determine the appropriate PCL tension to reproduce rollback. However, several in vivo studies have reported that prosthesis geometry directly affects knee kinematics, making it difficult to determine which factors most influence knee kinematics. The purpose of this two-center, two surgeons study was to evaluate knee kinematics of a single design of CR TKA. A total of 23 TKAs were studied fluoroscopically during a single-limb step-up/down maneuver. The average patient age at the time of TKA, knee score (HSS/KSS) and ROM were 70.6 years, 91.1 points and 116.9 degrees respectively. All patients had a PCL-retaining prosthesis of the same design using an unconstrained “flat” tibial insert. TKAs were performed by one surgeon at each hospital (Group 1:13 knees, Group 2: 10 knees). Both groups of knees exhibited ‘screw-home’ type axial rotations from 20° of flexion to full extension. In Group 1, rollback occurred early in the flexion range and was maintained until 80° of flexion. In Group 2, the lateral condyle exhibited rollback in early flexion, but both condyles translated forward as flexion increased to 80°. Medial and lateral contact were more posterior in Group 1 over most of the range of motion (p< 0.05). Although femoral rollback has been infrequently observed in similar studies of PCL retaining arthroplasties, our two-center, two surgeon data suggest that rollback can be achieved using this unconstrained prosthesis with PCL retention. However, there were consistent and statistically significant differences in the knee kinematics exhibited by the two groups of patients.

Aims: It has been suggested that the capture mechanism of modular polyethylene tibial inserts degrades with time in-situ. This study evaluates micromotion, polyethylene wear and tissue histology in contemporary cemented TKRñs retrieved at autopsy. Methods: Twelve cemented, PCL-retaining TKRñs of the same design were retrieved at autopsy after 41(15–74) months in-situ. Patient age and body weight averaged 73 years and 90 kg, respectively. Insert micromotion was measured according to published protocols on 6 of the 12 TKRñs in which the modular tibial component was undisturbed at retrieval and on 6 unused control components. Tissue histology was evaluated using a semi-quantitative grading system. Articular and backside surface damage was measured using published techniques. Results: There was no signiþcant difference (t-test, p=0.12) between the micro-motion index for retrieved inserts (154±121 um) and control inserts (62±53 um). Backside surface damage covered 38%±23% and was dimpled in appearance without scratching or pitting. Damage covered 46%±8% of the articular surface. Micromotion was negatively correlated with in-situ time (r=−0.94) and backside damage (r=− 0.97). Conclusions: Micromotion for these autopsy-retrieved TKRñs is less than half the 380 micron magnitude measured for other autopsy-retrieved designs, as reported by Engh. Micromotion was greatest on inserts with the least backside wear and the shortest time in-situ. These data suggest that backside damage resulted from axial compression of the polyethylene insert against the baseplate rather than micromotion.

Aims: During total knee replacement (TKR), bone dimensions are sometimes between implant sizes. Many surgeons select the smaller tibial component size to avoid overhanging the cortex and the smaller femoral component size to avoid overstuffing the joint space. However, the larger femoral component size is sometimes selected to ensure adequate bone coverage. This study was initiated after contact between the polyethylene insert and posterior femoral osteophytes was observed at autopsy even though radiographs showed adequate osteophyte removal at index TKR. It was hypothesized that knees implanted with the same sized femoral and tibial components would have a higher incidence of contact and abrasive wear than knees with larger femoral components. Methods: Thirty five polyethylene inserts were retrieved at autopsy (34%) and at revision TKR for reasons of infection (20%), patellar complications (17%), loosening (11%), patellar resurfacing (14%), and supracondylar fracture (3%). Mean implantation time was 32(1–74) months. Articular damage was evaluated using light microscopy. Results: Nineteen knees had smaller femoral components and 13 (68%) had abrasive wear on the polyethylene rim. Sixteen knees had larger femoral components and 4 (25%) had the abrasive wear pattern. The incidence of abrasive wear was significantly lower in knees with larger sized femoral components (Fisher’s Exact, p< 0.05). Conclusions: Surgeons are encouraged to remove all osteophytes that might impinge and avoid sizing the components such that the polyethylene insert overhangs the femoral component. Selecting the larger femoral component size may lessen impingement and provide some benefit for increasing knee flexion and decreasing abrasive wear.

Observations of knee arthroplasty kinematics generally show differences in anteroposterior translation when comparing posterior cruciate retaining (CR) and posterior stabilised (PS) designs. However, the PS cam/post mechanism is not engaged in extension. We hypothe-sised that there would be little difference between CR and PS knee kinematics during stance in gait.

Videofluoroscopy and shape matching techniques were used to quantify motions of 47 fixed-bearing knee arthroplasties (24 CR, 23 PS) during gait and stair-climbing in consenting patients with excellent clinical/ functional performance at least one year post-surgery. The average centre of rotation (COR) was computed for each knee during the two activities; a lateral COR (−50% to 0%) indicates anterior femoral translation with flexion, a medial COR (0% to +50%) indicates posterior femoral translation with flexion.

There was a significant difference between the average COR in the PS (+9%) and CR (−15%) knees for the stair climbing activity (p< 0.001), but not the stance phase of gait (−5% vs. −14%, respectively, p=0.664). The COR was more lateral for the stance phase of gait than for stair climbing in the PS knees (p=0.008), but not the CR knees (p=0.948). All knees showed more axial rotation during the stair activity (8°) than the stance phase of gait (5°, p< 0.001).

During stance in gait, there were small but not significant differences in the centre of rotation between the CR and PS knees. For stair climbing, there were significant differences between CR and PS knee kinematics. These observations are consistent with the hypothesis that CR and PS kinematics ought to be similar near extension, where the articular constraints are similar, but might differ in deeper flexion activities where the intrinsic constraints of the arthroplasty are different. An improved understanding of arthroplasty function should facilitate further evolution of design, surgical techniques, and numerical analyses to optimise patient performance.

Many total knee replacements (TKR) are designed with more conforming articular geometry to increase the femoral contact area and decrease surface stresses. These designs are supported by studies suggesting that implants with coronally flat articular surfaces are vulnerable to medial-lateral lift-off and edge-loading on the polyethylene insert. However, few retrieved inserts from contemporary TKR’s have shown wear consistent with this loading mechanism. This study presents wear measurements from 37 consecutively retrieved polyethylene inserts of the same PCL-retaining design with coronally flat-on-flat articulations. If substantial edge-loading occurred in-vivo, it was hypothesise that wear would be located closer to the medial or lateral edge of the articular surface with a high incidence of delamination.

Inserts were retrieved at autopsy (n=12) after 41 (15–74) months in-situ and at revision TKR (n=25) after 26 (1–71) months in-situ. Reason for revision was infection (28%), patellar component complications (24%), loosening (24%), patellar resurfacing (20%), and supra-condylar fracture (4%). Articular damage was measured using light microscopy and digitising the circumference of each damage region on calibrated images. Surface deformation was measured relative to unused control inserts using a hand-held digitising stylus.

Wear patterns were not significantly different between autopsy or revision retrievals (ANOVA, p> 0.05). Articular wear covered 48%+16% and 47%+14% of the medial and lateral surfaces, respectively. The most frequent wear modes were burnishing and scratching. Delamination occurred on 4(11%) inserts, but involved < 2% of the articular surface. Wear patterns were internally rotated and centrally located. Not one insert had a wear area centroid located in the medial or lateral third of the articular surface. Surface deformations were greatest in the inserts’ central region and the linear deformation rate decreased with time.

Concerns of high contact stresses associated with edge-loading were unsupported by these retrievals. Condylar lift-off, if it occurs, does not appear to substantially impact polyethylene damage in coronally flat-on-flat articulations.

Kneeling is an important aspect of daily living. Our goal was to describe the in vivo tibiofemoral kinematics during standing and kneeling after total knee arthroplasty (TKA).

Ten posterior substituting (PS) and 10 cruciate retaining (CR) TKA designs were studied in 18 patients. Radiographs were taken when standing, kneeling at 90°, and kneeling at maximal flexion. An image matching technique provided three-dimensional measurements of the femoral component position relative to the AP midpoint of the tibial baseplate.

When standing, the CR tibiofemoral contact position (medial: 7 mm ± 3; lateral: 6 mm ± 3) was more posterior than the PS design (medial: 5 mm ± 2; lateral: 5 mm ± 2). Movement from standing to kneeling at 90° produced different responses. CR knees translated anteriorly (medial: 4 mm ± 4; lateral: 2 mm ± 6), while PS knees translated posteriorly (medial: 0.2 mm ± 3; lateral: 1 mm ± 4). During kneeling, movement from 90° to maximum flexion produced posterior translation of the femur (CR medial: 5 mm ± 4: CR lateral: 5 mm ± 4; PS medial: 6 mm ± 4; PS lateral: 6 mm ± 3). The relationship between the tibiofemoral contact position and flexion angle during kneeling was more variable for CR knees (r2=0.38) than PS knees (r2=0.64), indicating that PS knees provide a more reliable AP position than CR knees.

PS knees dislocate when the arch of the femoral cam slides over the tibial post; CR knees sublux when the femoral contact position translates beyond the edge of the tibial baseplate. The distance to dislocation averaged 13 mm ± 2 for PS knees, and 20 mm±4 for CR knees.

Many patients wish to resume normal activities, including kneeling after TKA. This study provides information for surgeons and patients considering kneeling after TKA.

Tibiofemoral motions are fundamental to the function (strength, stability, ROM) and longevity of total knee replacements (TKR). Although a wide range of TKR kinematics have been reported, few studies have reported kinematics of a single TKR design utilising a variety of tibial articular surfaces. We hypothesised that increased articular constraint, from four different tibial inserts, would result in reduced tibio-femoral translations during dynamic activities.

We tested 22 knees with excellent early clinical outcomes after primary TKR. All knees received the same PCL retaining arthroplasty; with six curved tibial inserts, six flat inserts, six laterally pivoting inserts and four translating/rotating mobile bearing inserts. Fluoroscopic images of knees were acquired during gait, stair, and deep flexion activities. CAD model based shape matching was performed to determine 3D knee kinematics.

There were significant differences in medial condy-lar translations for all activities, none for the lateral condyle. The medial condyle in knees with flat and mobile bearing inserts translated more anterior with flexion than knees with curved or pivoting inserts. Medial condyle translations were greater in mobile bearing knees than knees with flat inserts.

Our results indicate that condylar motions in TKR’s during dynamic activities can be modulated in a reasonably predictable manner by varying the degree of tibio-femoral constraint. Furthermore, the results show that significant control of translation can be achieved through asymmetric tibial insert conformity. These findings suggest it is possible to achieve a particular pattern of tibio-femoral translations and rotations in vivo through careful selection or design of the articular geometry.

Range of motion after total knee arthroplasty (TKA) is increasingly an issue of critical concern in the performance of knee replacements and their ability to meet the functional demands of diverse patient populations. The goal of this study was to measure maximum weight bearing flexion in patients with one knee replaced using a posterior cruciate retaining (CR) device and the other a cruciate substituting (PS) device on a prospective basis.

Sixteen patients (32 knees) with bilateral TKA and excellent clinical/functional outcomes at least one year after surgery participated in this study. Eight patients received knee replacements from one surgeon, and eight patients received knee replacements of another design from a second surgeon. Their knees were imaged using fluoroscopy as the patients were asked to bend to maximum flexion with their foot on a 25 cm step. CAD model based shape matching techniques were used to measure knee flexion, axial rotation, and the anterior/ posterior (AP) location of tibio-femoral contact relative to the AP centre of the tibial insert. Paired t-tests were used to evaluate differences in means (p = 0.05).

PS knees had larger average flexion angles (121±8 deg vs. 114±5 deg, p=0.01) and greater femoral rollback (14±3 mm vs. 12±3 mm, p=0.02) than the CR knees. There was no difference in axial rotation (6±4 deg vs. 5±6 deg). The same trends were observed within the single design subgroups.

In patients with heterogeneous bilateral TKA, greater femoral rollback and weight-bearing flexion is exhibited by the knee with a posterior stabilised TKA.

Our purpose was to determine the mechanism which allows the maximum knee flexion in vivo after a posterior-cruciate-ligament (PCL)-retaining total knee arthroplasty.

Using three-dimensional computer-aided design videofluoroscopy of deep squatting in 29 patients, we determined that in 72% of knees, direct impingement of the tibial insert posteriorly against the back of the femur was the factor responsible for blocking further flexion.

In view of this finding we defined a new parameter termed the ‘posterior condylar offset’. In 150 consecutive arthroplasties of the knee, the magnitude of posterior condylar offset was found to correlate with the final range of flexion.