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Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 374 - 375
1 Oct 2006
Waite J Gill H Beard D Dodd C Murray D
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Introduction: Numerous studies in the orthopaedic literature have reported changes in knee kinematics following rupture of the Anterior Cruciate Ligament (ACL). Gait analysis is currently the preferred method for studying these in vivo kinematics. The accuracy of this method of analysis remains limited due to errors related to skin movement artefact. Most studies have therefore been limited to analysing subjects performing simple tasks such as straight-line walking, since results become increasingly inaccurate as the subject moves faster. Standard skin marker formats allow measurements of knee flexion angle and varus/valgus angles to be recorded relatively accurately during such tasks. Accurate measurements of rotations and translations at the knee joint, however, are not possible with these set-ups.

Aim: To produce a new method for interpretation of kinematic data from gait analysis, to allow accurate measurement of 3-D displacements at the knee joint during dynamic activity.

Method: We employed two different sets of skin markers in an attempt to increase the accuracy of our data, by diminishing the effects of skin movement. The Kabada1 marker set was used with retroreflective spheres of 14.5mm diameter. This marker set was used to establish 3-D femoral and tibial co-ordinate systems. We then established a femoral and tibial co-ordinate centre within the distal femur and proximal tibia respectively. A second set of markers was used similar to the “point-cluster” method described by Andriacchi et al2. This involved groups of eight smaller spheres (9.5mm diameter) placed in a non-uniform distribution on each of the thigh and shank segments. The positions of all these remaining markers, relative to the co-ordinate centres were then established. 15 subjects were then recorded while performing a series of running and cutting tasks. For each trial that was then analysed, we used all visible markers to optimize the recorded position of the tibial and femoral co-ordinate centres, using a method similar to that described by Soderkvist3. The displacements of these co-ordinate centres were then used to calculate the 3-D tibio-femoral kinematics. Reliability and repeatability tests suggest that this method produces results accurate to 3–4mm.

Conclusion: We believe we have developed a practical and accurate method to analyse 3-D joint kinematics from gait laboratory data.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 387 - 388
1 Oct 2006
Isaac S Barker K Danial I Beard D Gill H Gibbons C Dodd C Murray D
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Introduction: Knee joint arthroplasty (total or unicompartmental) is the standard operative treatment for osteoarthritis (OA). Survival rate is good for both types but functional outcome is different. The function of unicompartmental knee arthroplasty (UKA) is substantially better than that of total knee arthroplasty (TKA). As function can be strongly influenced by proprioceptive ability, it is possible that improved outcome seen in patients with UKA results from retaining proprioceptive function associated with the cruciate ligaments. This prospective longitudinal study aimed to evaluate the change in proprioceptive performance after knee replacement; comparing TKA to UKA.

Methods and Materials: Two groups of patients with OA as diagnosed clinically and by X-ray were recruited. Group 1 consisted of 15 patients (mean age 65.8 years range 57–72 years, 10 females and 5 males) listed for TKA with the AGC prosthesis (Biomet, UK). Group 2 consisted of 19 patients (mean age 65.5 years range 52–75 years; 9 females and 10 males) listed for UKA with the Oxford UKA (Biomet, UK) for medial compartment OA. The ACL and PCL were present and preserved in all patients in Group 2, while only the PCL was preserved in Group 1 patients. Joint Position Sense (JPS) and postural sway were used as measures of proprioception performance. Both groups were assessed pre-and 6 months post-operatively in both limbs. JPS was measured using a dynamometer (KinCom, Chatanooga Ltd) as the error in actively and passively reproducing five randomly ordered knee flexion angles (30°, 40°, 50°, 60° and 70°). Postural sway (area, path and velocity) was measured during single leg stance using a Balance Performance Monitor (SMS Medical) for 30 seconds interval. Functional outcome was assessed using the Oxford Knee Score (OKS).

Results: Pre-operatively, no differences in JPS or sway were found between limbs in either group. No differences existed between the two groups. Post-operatively, both groups had significant improvement of JPS in the operated limb only (Mean ± standard deviation for UKA 4.64±1.44° and for TKA 5.18±1.35°). No changes in JPS were seen in the control side. An improvement in sway was found in the UKA group only. UKA patients showed significant improvement in both sway area and path (p< .0001) for both limbs post-operatively. No significant post-operative changes in sway occurred in either limb of TKA patients. The OKS improved postoperatively in both groups, rising from 21.4 to 35.5 for TKA patients and from 23.9 to 38 for UKA patients.

Conclusion: Interestingly, joint position sense improved for both groups but did not seem to show any difference between UKA and TKA. Postural sway was influenced by joint replacement type. Ligament retention may contribute to improved global postural control seen after unicompartmental knee arthroplasty and may explain the higher level of function seen in these patients.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 414 - 414
1 Oct 2006
Steffen R Smith S Gill H Beard D McLardy-Smith P Urban J Murray D
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Purpose This study aims to investigate blood flow in the femoral head during Metal-on-Metal Hip Resurfacing (MMHR) through the posterior approach by monitoring oxygen concentration during the operative procedure.

Methods Following division of fascia lata, a calibrated gas-measuring electrode was inserted into the femoral neck, aiming for the anterolateral quadrant of the head. Baseline oxygen concentration levels were detected after electrode insertion 2–3cm below the femoral head surface and all intra-operative measures were referenced against these. Oxygen levels were continuously monitored throughout the operation. Results of measurements from ten patients are presented.

Results Oxygen concentration was reduced during the surgical approach and average oxygen concentration following dislocation and circumferential capsulotomy dropped to 43% of baseline (Std.dev +/−37%), this was a highly significant reduction (p< 0.005). Insertion of implants resulted in a further significant drop in oxygen concentration (p< 0.02) to 16% of baseline (Std. dev +/−27%). Oxygen concentration rose slightly after relocation of the resurfaced joint and reconstruction of posterior soft tissues, reaching 22% (Std.dev +/−31%) of initial baseline oxygen levels. Considerable variation between subjects was observed. Three subjects had no remaining oxygen concentration at the end of surgery.

Conclusion Intra-operative measurement of oxygen concentration in blood perfusing the femoral head is feasible. During MMHR there is a dramatic decrease in femoral oxygenation during surgical approach and implant fixation. This may increase the risk of avascular necrosis and subsequent femoral neck fracture. Future experiments will determine if less invasive procedures or a different approach can protect the blood supply to femoral neck and head.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 304 - 304
1 May 2006
Steffen R Smith S Gill H Beard D Urban J Murray D
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Introduction: The incidence of femoral neck fracture is approximately 2% after resurfacing hip replacement. Avascular necrosis is thought to be a contributory factor. The aim of this study was to investigate oxygen concentration in the femoral head during metal-on-metal hip resurfacing (MMHR).

Materials and Methods: In ten patients, following division of the fascia lata, a calibrated gas-measuring electrode was inserted into the supero-lateral quadrant of the femoral head via the femoral neck. Xsrays confirmed placement of the electrode 2-3 cms below the femoral head surface. Baseline oxygen concentration levels were recorded immediately upon electrode insertion and used as a reference for all intra-operative measures. Oxygen levels were monitored continuously throughout the operation.

Results: Oxygen concentration was reduced during the surgical approach and average oxygen concentration following dislocation and circumferential capsulotomy dropped significantly (p< 0.005) to 38% of baseline (SD=26%). Insertion of implants resulted in a further significant drop in oxygen concentration (p< 0.04) to 21% of baseline (SD=28%). Oxygen concentration rose slightly, but not significantly after relocation of the resurfaced joint and reconstruction of posterior soft tissues, reaching 22% of initial baseline oxygen levels. Considerable variation between subjects was observed.

Discussion: Intra-operative measurement of oxygen concentration in blood perfusing the femoral head is possible. During MMHR there is a dramatic decrease in femoral head oxygenation during surgical approach and implant fixation. This may increase the risk of avascular necrosis and subsequent femoral neck fracture. Future experiments will determine if a different surgical approach can protect the blood supply to the femoral head and neck. Measurements of femoral head oxygenation during metal-on-metal hip resurfacing demonstrated a significant concentration decrease during surgical approach and implant fixation.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 87 - 87
1 Mar 2006
Aldinger P Gill H Rumolo C Schlegel U Murray D Breusch S
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Background: In anteromedial osteoarthritis, only the medial compartment of the knee is affected and the collateral ligaments as well as the cruciate mechanism are intact. These preconditions make the knee suitable for UKA. Our hypothesis was that no difference in tibiofemoral kinematics is observed after UKA. In addition we also hypothesised that the results of the image guided surgery would be the same as the normal surgical procedure.

Design/Methods: To test this hypothesis, we conducted a study using 13 normal human cadaveric knees. For kinematic analysis, the SurgeticsTM surgical navigation system (Praxim, France), equipped with custom written tracking software, was used. Reference markers were mounted to the proximal tibia and the distal femur. In a standardised set-up, the knee was positioned in a leg holder and preoperative kinematics of the normal knee was recorded after a para-patellar mini-incision . Joint kinematics were recorded during passive knee flexion and plotted against flexion angle. Oxford UKA was performed; the standard Phase III instrumentation was used for six knees and the image guided procedure was used for seven knees. After the operation postoperative kinematics were recorded using the same measurement protocol. All data were processed using Matlab 6.1 analysis software (The MathWorks Inc., MA, USA). Preoperative and postoperative tibiofemoral kinematics were determined and compared. The mechanical axes of the tibia and femur were determined and kinematics represented as functions of knee flexion range. Over both the flexing and extending cycles of the knee the changes in tibiofemoral rotation (ΔROT), tibiofemoral ab/adduction (ΔABD), and distances between the origins of the mechanical axes (ΔX, ΔY, ΔZ) were calculated between pre and post-operative states.

Results: The mean differences between pre- and postoperative kinematics for all cases are given as the mean and range in parentheses. For the flexing cycle was ΔROT −0.06 (6.08 to −3.93) degrees, ΔABD was −0.04 (3.39 to −5.72) degrees, ΔX was 0.69 (2.69 to −1.84) mm, ΔY was −0.22 (4.13 to −3.41) mm and was ΔZ 0.27 (4.09 to −1.47) mm. For the extending cycle was ΔROT 0.1 (5.87 to −3.61) degrees, ΔABD was −0.06 (5.72 to −5.95) degrees, ΔX was 0.35 (2.73 to −2.39) mm, ΔY was −0.39 (5.58 to −3.08) mm and was ΔZ 0.21 (3.77 to −1.12) mm. There were no observable differences between the standard and image guided changes in kinematics. Overall, no observable differences were found between pre and post-operative kinematics.

Conclusions: The image guidance system used in our study is a valuable tool for assessing pre- and postoperative knee kinematics. Oxford Unicompartmental Knee Arthroplasty with the Phase III instrumentation in the presence of the cruciate mechanism reproduces the normal kinematics of the knee very accurately.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 57 - 57
1 Mar 2006
Steffen R Smith S Gill H Beard D Jinnah R McLardy-Smith P Urban J Murray D
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Introduction Metal-on-Metal Hip Resurfacing (MMHR) has been established as a successful alternative to Total Hip Replacement (THR). However, several series report a 2 % incidence of early femoral neck fractures. Avascular necrosis (AVN) was considered to be responsible for the majority of observed fractures, raising concerns about the femoral head blood supply during MMHR. This study aims to further understand the mechanisms of femoral blood flow restriction by monitoring gas levels (O2) during the operative procedure.

Methods Patients undergoing MMHR using the posterior approach were evaluated. Following division of fascia lata, a guide wire was introduced up the femoral neck, aiming for the anterosuperior quadrant of the head. It was then removed. A calibrated gas-measuring electrode was inserted in the created bone channel. X-ray confirmation was obtained to ensure that the active measurement area of the electrode was 2–3cm below the femoral surface. O2 and N2O levels were then continuously monitored throughout the operation.

Results A preliminary analysis of four patients is presented: Stable N2O- measurements throughout the procedure confirmed valid electrode measurements. Baseline oxygen concentration levels of 40%– 60% were detected before division of short rotators. After hip dislocation oxygen concentration dropped in all patients to levels ranging between 0% and 5%. Oxygen concentration was found to remain depressed at these levels throughout the entire operation in three patients. Recovery of O2 concentration to baseline levels was observed in one patient 15 minutes after dislocation.

Discussion In three patients the extended posterior approach and joint dislocation had a dramatic effect on the perfusion in the femoral head. These patients have a high risk for development of AVN and potential femoral neck fracture. Whilst the results require further verification, subsequent experiments will determine if less invasive procedures or specific positioning of the limb can protect the femoral blood supply.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 73 - 73
1 Mar 2006
Hauptfleisch J Glyn-Jones S Beard D Gill H McLardy-Smith P Murray D
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Introduction: The Charnley Elite femoral component was first introduced in 1992 as a new design variant of the original Charnley femoral component (De Puy, Leeds, UK) with modified neck and stem geometry. The original component had undergone few changes in nearly forty years and has excellent long-term results.

Early migration of the new stem design was determined by Roentgen Stereophotogrammetric Analysis (RSA). Rapid early migration of a component relative to the bone, measured by RSA, is predictive of subsequent aseptic loosening for a number of femoral stems. As there was rapid early migration and rotation of the Charnley Elite stem, we predicted that the long-term results would be poor. An outcome assessment is required as stems of this type are still being implanted.

Materials and method: One hundred Charnley Elite stems, implanted in our centre between 1994 and 1997 were included in a prospective, cross-sectional follow-up study. Outcome measures include validated clinical scores (Charnley hip score, Harris hip score and Oxford hip score) and radiological scores (Gruen classification) as well as revision rates over the past 10 years.

Results: The preliminary analysis results are given. The mean time to follow-up was 8.28 years. 20 patients have died due to causes unrelated to their operations. 10 patients had stem revisions: 9 for aseptic loosening and 1 for a peri-prosthetic fracture. This indicates a significant 10% failure rate of the prosthesis in less than 10 years.

Preliminary clinical scores in the patients who had not undergone any subsequent surgery were adequate (Oxford Hip Score mean average of 23.9).

Thirteen percent of radiographs analysed had evidence of loosening, giving an overall loosening rate of 14% at 8 years.

Discussion and conclusion: The clinical follow-up supports the RSA predictions of early failure of the Charnley Elite femoral stem.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 11 | Pages 1493 - 1497
1 Nov 2005
Price AJ Short A Kellett C Beard D Gill H Pandit H Dodd CAF Murray DW

Polyethylene particulate wear debris continues to be implicated in the aetiology of aseptic loosening following knee arthroplasty. The Oxford unicompartmental knee arthroplasty employs a spherical femoral component and a fully congruous meniscal bearing to increase contact area and theoretically reduce the potential for polyethylene wear. This study measures the in vivo ten-year linear wear of the device, using a roentgenstereophotogrammetric technique.

In this in vivo study, seven medial Oxford unicompartmental prostheses, which had been implanted ten years previously were studied. Stereo pairs of radiographs were acquired for each patient and the films were analysed using a roentgen stereophotogrammetric analysis calibration and a computer-aided design model silhouette-fitting technique. Penetration of the femoral component into the original volume of the bearing was our estimate of linear wear. In addition, eight control patients were examined less than three weeks post-insertion of an Oxford prosthesis, where no wear would be expected. The control group showed no measured wear and suggested a system accuracy of 0.1 mm. At ten years, the mean linear wear rate was 0.02 mm/year.

The results from this in vivo study confirm that the device has low ten-year linear wear in clinical practice. This may offer the device a survival advantage in the long term.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 226 - 226
1 Sep 2005
Pandit H Hollinghurst D Ward T Gill H Beard D Murray D Thomas N
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Introduction: Total knee replacement (TKR) is a common treatment for end stage osteoarthritis of knee. The best knee replacement is one in which the kinematics of the normal knee are reproduced. Amongst several factors affecting kinematics, variation in surface geometry and the retention/ sacrifice of the PCL are considered especially important. It is not known which of these two factors is most influential for establishing optimum joint kinematics after TKR.

Method: Four groups of patients who had undergone TKR at least one year previously were recruited. Two groups of patients had undergone replacement with a single axis design (Scorpio, Stryker Howmedica) in both PCL retaining (Scorpio CR, n=15) and PCL sacrificing (Scorpio CS, n=15) variants. The other two groups had undergone replacement with the traditional polyradial design prosthesis (Sigma, Depuy, Johnson & Johnson), again with both PCL retaining (Sigma CR, n=14) and PCL sacrificing (Sigma CS, n=13) variants. An in-vivo fluoroscopic analysis was carried out on all patients. Patients were asked to perform closed chain step up and open chain extension and flexion against gravity. The kinematic profile of each knee was obtained by measuring patella tendon angle (PTA) at specific angles of knee flexion (KFA) using an established fluoroscopic method. The data was also compared with the kinematic profile of normal knees. American Knee Society, Oxford and Patella Scores were recorded for all patients.

Results: All groups were comparable in terms of age and gender. In addition, no significant difference was found between groups in clinical outcome. PTA results for a step-up exercise are shown in the figure. A one way ANOVA between groups revealed that knee kinematics after total knee replacement is different to that for normal knees. No differences were found between groups when the data was analysed using CR/CS as the independent variable. The only differences between groups were found when surface geometry was used as the independent variable. It was shown that the kinematic profile of the single axis Scorpio design (in both CR & CS ) was closer to normal, especially near extension, than the traditional polyradial design (Sigma CR & CS).

Conclusions: Kinematics after a total knee replacement differ from that for a normal knee. Differences in surface design between knee replacements appear to have greater influence on kinematics than the presence or absence of the PCL.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 348 - 348
1 Sep 2005
Waite J Gill H Beard D Dodd C Murray D
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Introduction and Aims: Since existing data relating to the kinematics of ACL-deficient knee joints relates mainly to walking, the kinematics during more dynamic activities remains unknown; therefore, the aim of this unique study was to describe in vivo ACL-deficient knee kinematics and muscle activity during running and cutting.

Method: Fifteen subjects with proven unilateral ACL rupture were measured performing running and cutting tasks prior to surgical reconstruction. Gait analysis was used to determine inter-limb differences in displacements at the knee joint during stance phase. Simultaneous EMG analysis was performed to give temporal measures of lower limb muscle activity.

Results: No significant inter-limb difference was seen for tibio-femoral translation in the sagittal or coronal planes during any part of stance phase. The ACLD limb showed a significantly reduced maximum knee flexion angle (40.4 vs. 44.0 degrees) compared to the ACL-intact (ACLI) limb (p=0.04). Internal tibial rotation was significantly greater (7.3 vs. 0.7 degrees) in the ACLD limb at toe-off (p=0.03). The quadriceps muscle group was found to be active for a significantly greater percentage of stance phase in the ACLD limb compared to the ACLI limb (p=0.001).

Conclusion: The ACL-deficient gait involves consistently greater knee extensor activity than ACL-intact gait during running, and as a consequence maximum knee flexion angle is reduced. These findings contrast with the description of ‘quadriceps-avoidance’ gait often described for ACL-deficient subjects. ACL-deficient gait also demonstrates increased rotational instability during terminal stance phase.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 344 - 344
1 Sep 2005
Hollinghurst D Stoney J Ward T Robinson B Price A Gill H Beard D Dodd C Newman J Ackroyd C Murray D
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Introduction and Aims: Single compartmental replacement procedures are increasingly preferred over total knee replacement (TKR) for single compartment osteoarthritis of the knee joint. Theoretically, reduced disruption of the native joint should produce more normal kinematics. This study aimed to describe and compare the sagittal plane kinematics of four different, commonly used devices.

Method: Four groups of patients who had undergone successful single compartment replacement at least two years previously were recruited. Fifteen following Oxford medial UKA, 12 following medial St Georg Sled UKA, five following Oxford lateral UKA, and 12 following Avon PFJ replacement. Patients performed flexion/extension against gravity, and a step-up during video fluoroscopy. The Patellar Tendon Angle (PTA), the angle between the long axis of the tibia and the patella tendon, was obtained as a function of knee flexion. This relationship provides indication of sagittal movement between femur and tibia through range and has been validated as a reliable measure of joint kinematics.

Results: The kinematic profile for each group was compared to that of the profile for 12 normal and 30 TKR (AGC) knees. All three tibiofemoral devices produced knee kinematics similar to the normal knee. The PTA was found to have a linear relationship to flexion angle, decreasing with increasing knee flexion angle. No such linear relationship exists for the TKR joint, which display abnormal kinematics. The PF device also reflected similar trends to that for normal knees except that the PTA was moderately increased throughout the entire range of flexion (three degrees).

Conclusion: In contrast to TKR, all single compartmental knee replacements provided kinematics similar to the normal joint. The kinematic pattern of the PFJ replacement may be of most interest as the observed increase in PTA through range could influence patello-femoral contact forces


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 224 - 224
1 Sep 2005
Glyn-Jones S Gill H McLardy-Smith P Murray D
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Introduction: The Birmingham Hip Resurfacing (BHR) is a metal on metal prosthesis with no published independent clinical studies. It is increasingly used as an alternative to stemmed prostheses in younger patients.

This study presents the 2 year migration results of the BHR femoral component using Roentgen Stereophoto-grammteric Analysis (RSA).

Methods: 26 hips in 24 subjects underwent a BHR, through the postero-lateral approach using CMW3G cement. RSA marker balls were placed in the cortical bone of the femur intra-operatively. The femoral component migration was measured at intervals of 3, 6, 12 and 24 months postoperatively using the Oxford RSA system. The implants were un-modified, geometric algorithms were used to identify the femoral component.

Results: The BHR femoral component showed no significant displacement from its immediate post-operative position. All components of migration showed no significant displacement in any direction, at 1 or 2 years.

Conclusion: The BHR femoral component does not migrate significantly within the first two post-operative years. Its’ migration compares favourably to other designs of femoral component. The BHR is therefore likely to remain stable in the future, as the majority of implant migration occurs within the first two years.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_IV | Pages 403 - 403
1 Apr 2004
Glyn-Jones S Gill H Murray D
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Introduction: This study investigates the influence of surgical approach on the early migration of a cemented Total Hip Replacement (THR), assessed by Roentgen Stereo-photogrammetric Analysis (RSA). Rapid early migration has been correlated with premature implant failure.

Method: 46 patients awaiting THR were allocated into Posterior Approach (PA) and Lateral Approach (LA) groups. RSA was used to assess post-operative stem position and migration at 1 year. Post-operative gait was examined for a subgroup of patients.

Results: There was no difference in initial stem position within the medulla. Significant differences in distal migration were found; (LA 0.78±0.07mm and PA 1.27±0.15mm), p< 0.01. Posterior head migration for the PA group (0.78±0.18mm) was twice that for the LA group (0.46±0.08mm), p< 0.05. The PA group showed greater medial migration of the prosthesis tip (0.62±0.24mm), compared to the LA group (0.11±0.08mm), p< 0.05. During gait, the legs of the PA group were relatively internally rotated when compared to those of the LA group.

Discussion: The PA implants rotate internally and into valgus further than the LA implants. The starting positions of the prostheses were the same with similar cement and prostheses characteristics. We can infer that surgical approach and therefore muscle function have a significant effect upon component migration. During gait, the PA group has relatively internally rotated legs, probably due to short external rotator weakness. Hence, the internally rotating torque on the femoral stem will be larger, explaining the rapid migration in this direction. With the LA approach, the abductors are likely to be damaged. Therefore, the PA joint reaction force will be more laterally directed, explaining the higher coronal plane rotation rates seen in this group.

Conclusion: Profound differences exist in early migration, between the LA and PA. Different muscle function may account for this and probably influences long-term outcome.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 260 - 261
1 Mar 2004
Glyn-Jones S Gill H McLardy-Smith P Murray D
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Aim: Small amounts of subsidence may be beneficial in stabilising a stem & appears to be a featue of polished tapered stems. Stem rotation (measured as posterior head migration) within the cement mantle, however, is probably a more important mechanism of failure than subsidence. Stems with a wider proximal portion are thought to better resist rotation. The CPS (Endoplus, UK) is such a device; here we compare its’ stability with that of the Exeter (Stryker-Howmedica, UK). Method: 20 patients received the CPS-plus stem & underwent RSA examinations at 3, 6 & 12 months postoperatively. The Exeter 1 year migration data (32 hips) was used as a comparison. Both groups underwent a Hardinge approach & the prosthesis was secured with CMW3G cement. Results: Both stems subsided about 1mm. The CPS showed less medio-lateral & A-P movement of the proximal stem than the Exeter over 1 year, as shown below: 1 Year Mean Migration ± SEM (mm) Discussion: The CPS internally rotates less than the Exeter, as demonstrated by the smaller amount of posterior head migration. It has a lateral flare of the shoulder; making its’ cross-section wider than the Exeter’s, this probably produces a greater resistance to rotation. The CPS also undergoes less medio-lateral proximal stem migration. Its’ lateral shoulder flare is probably responsible for this axial subsidence, as it prevents the shoulder from moving laterally whilst subsiding onto the calcar.

Increasing the width of the proximal section of a polished tapered stem enhances its rotational stability.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 19 - 19
1 Jan 2004
Glyn-Jones S Gill H McLardy-Smith P Murray D
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The relative motion between a prosthesis, the cement mantle and its’ host bone during weight bearing is not well understood. Using Radiostereophotogrammetric Analysis (RSA), we examined the dynamically inducible micromotion that exists at these interfaces when an increased load is placed through the prosthesis.

Dynamically inducible micromotion was measured in the femoral components of 21 subjects undergoing total hip replacement with polished Exeter stems. Two standing RSA studies were performed, at 3 and 12 months postoperatively. Firstly in double-leg stance, and secondly fully weight bearing through the operated hip.

Subjects had no signs of clinical or radiological signs of loosening at 1 year. Significant micromotion was detected at the prosthesis-cement interface at 3 months.

Similar patterns of micromotion were observed at 12 months. The prosthesis appeared to bend during single-leg stance weight bearing, however this accounted for less than half of the total observed movement.

Conventional RSA studies were conducted at 3 months, 6 months and 1 year to confirm that the implants showed normal migration patterns.

This study demonstrates that movement exists between the prosthesis and bone during cyclical weight bearing. This dynamically inducible micromotion probably occurs at the prosthesis-cement interface. It could account for the wear that is observed on the surface of retrieved secure prostheses. This may be a mechanism by which failure eventually occurs.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 12 - 12
1 Jan 2004
Pandit H Price A Rees J Beard D Gill H Dodd C Murray D
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The indications for unicompartmental knee arthroplasty (UKA) can be contentious. Concerns exist about implanting a UKA in younger individuals. It has been reported that it is contra-indicated in patients under the age of 60. The suggestion is that younger patients may compromise their outcome after surgery by their increased activity levels. However, the number of publications with data on UKA in young patients is minimal and the age/activity related criteria for UKA remains unknown.

The aim of the study was 1) to confirm that younger UKA patients have higher activity levels than older patients, and 2) to test the hypothesis that younger, more active patients have inferior outcome when compared to older less active patients.

Fifty consecutive patients undergoing UKA who were under 60 years (Group Y) and 50 patients over 60 years (Group O) were recruited. Indications were anteromedial arthritis with full thickness lateral compartment cartilage, a functioning ACL and a correctible varus. All patients underwent Oxford UKA using the minimally invasive technique. This device employs an unconstrained fully congruous meniscal bearing. Outcome was evaluated using Knee Society Scores. Activity level was documented using Tegner Activity Score.

Average age of patients for group Y and O was 55 and 68 years respectively. Minimum follw-up was 2 years. pre-op. knee scores were comparable for each group. (y: 38.8, O: 35.8) and patients in both groups siginificantly improved after surgery. A significant difference in Tegner score was found between the two groups after surgery (y:4.1, O:2.6). More than 50% of younger patients regularly participated in high demand activities like skiing, tennis and manual labour. No statistically significant differences in any other post op. knee scores or complication rate were found despite adequate study power.

Younger patients have increased activity levels after UKA when compared to an older age group. There is no evidence that the outcome of UKA in younger more active patients will be inferior to those who are older and more sedentary.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 19 - 19
1 Jan 2004
Glyn-Jones S Gill H McLardy-Smith P Murray D
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The Birmingham reSurfacing Arthroplasty (BSA) is a metal on metal prosthesis with no published independent clinical studies. Despite this, it is increasing in popularity, especially as an alternative to stemmed prostheses in younger patients. This study presents the 1year migration results of the BSA femoral component using Roentgen Stereophotogrammteric Analysis (RSA).

Twenty six subjects underwent a BSA, through the postero-lateral approach using CMW3G cement, with RSA marker balls placed intra-operatively. The femoral component migration was measured at intervals of 3, 6 and 12 months using the Oxford RSA system. Geometric algorhythms were used to identify the femoral component. The data was examined for distribution prior to analysis. All statistical analysis was performed using the t-test.

The data was normally distributed. The 1 year migration results of the BSA femoral component are displayed below.

All cemented implants migrate in vivo. The majority of cemented stemmed implant migration occurs within the first post-operative year. High rates of migration within the first post-operative year correlate with premature component failure in some instances. The BSA is a fundamentally different design to most cemented prostheses, despite this we know that very large migrations, those in excess of 2mm/year in any direction are generally regarded as poor indicators of long term outcome. These results suggest that the BSA femoral component is an inherently stable device as it does not migrate significantly within the first post-operative year. Only long-term independent clinical studies and continued RSA follow-up will enable a comprehensive evaluation of the device.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 8 - 9
1 Jan 2003
Glyn-Jones S Gill H Murray D
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This study examined the effect of surgical approach on the 1year migration of the Exeter stem, using Roentgen Stereophotogrammetric Analysis (RSA). There is evidence that implants with increased early migration, particularly those moving into internal rotation, are likely to have a higher failure rate.

A total of 46 patients awaiting THR were allocated into 2 groups. Both groups underwent an Exeter Total Hip replacement, one through the Posterior Approach (PA), and the other through the Hardinge Approach (HA). RSA was used to assess post-operative stem position and migration at 1 year. Post-operative gait analysis and clinical evaluation was used to assess a subgroup of patients.

There was no difference in the initial stem position of each group within the femoral canal. Significant differences in migration were found for migration of the head distally and posteriorly and for the tip medially. During gait, the legs of the PA group were relatively internally rotated when compared to those of the HA group. Relative to the supporting bone, the PA implants internally rotate and also rotate into valgus further than the HA implants. The starting position of the prostheses was the same and the cement and prosthesis characteristics were similar. From this, we can infer that surgical approach and therefore muscle function, have a large influence on component migration. During gait, the PA group had internally rotated legs compared to the HA group. This is probably due to short external rotator weakness in the PA group. As a result the internally rotating component of the posteriorly directed joint reaction force on the femoral stem will be larger. This probably explains the rapid internal rotation seen in the implants of the PA group. With the HA group, because of abductor damage there is likely to be a smaller component of the joint reaction force acting on the stem. This would explain the smaller rates of observed coronal plain rotation (rotation into valgus).

Profound differences exist in early migration, between the HA and PA. Different muscle function may account for this and probably influences long-term outcome.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 363 - 363
1 Nov 2002
Pandit H Price A Rees J Beard D Gill H Murray D Dodd C
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Introduction: The indications for unicompartmental knee arthroplasty (UKA) can be contentious. Concerns exist about implanting a UKA in younger individuals and it has been reported that the procedure is contra-indicated in patients under the age of 60. The suggestion is that younger patients may compromise their outcome after surgery by their increased activity levels. However, the number of publications with data on UKA in young patients is minimal and the age/activity related criteria for UKA remains unknown.

Aim: The aim is twofold: 1) to confirm that younger UKA patients have higher activity levels than older patients, and 2) to test the hypothesis that younger, more active patients have inferior outcome when compared to older less active patients.

Materials and methods: Fifty consecutive patients undergoing UKA who were under 60 years old at the time of surgery (Group Y) and 50 patients over 60 years (Group O) were recruited. Indications were anteromedial arthritis with full thickness lateral compartment cartilage, a functioning ACL and a correctible varus deformity. All patients underwent Oxford UKA using the minimally invasive technique. This device employs an unconstrained fully congruous meniscal bearing. Outcome was evaluated using the American Knee Society Score (AKSS). Activity level was documented using the established Tegner Activity Score.

Results: The average age of patients for group Y and O was 55 years and 68 years respectively. Minimum follow up for both groups was 2 years. Pre-operative AKSS scores were comparable for each group (Group Y = 38.8, Group O = 35.8) and patients in both groups significantly improved after surgery. A significant difference in Tegner score was found between groups after surgery (Group Y = 3.9, Group O = 2.6). It was found that 40% of younger patients regularly participate in high demand activities like skiing, tennis, hard manual labour and swimming. No statistically significant difference in any other post operative knee scores or complication rate were found despite adequate study power.

Conclusions: Younger patients have increased activity levels after UKA when compared to an older age group. There is no evidence that the outcome of UKA in younger more active patients will be inferior to those who are older and more sedentary.