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Volume 101-B, Issue SUPP_11 October 2019 The Knee Society (TKS) 2019 Members Meeting, Cape Neddick, ME, USA, 5–7 September 2019.

D. W. Murray C. A. F. Dodd

Introduction

Unicompartmental knee replacement (UKR) offers advantages over total knee replacement but has higher revision rates particularly for aseptic loosening. Cementless UKR was introduced in an attempt to address this. We used National Joint Registry (NJR) data to compare the 10-year results of cemented and cementless mobile bearing UKR whilst matching for important patient, implant and surgical factors. We also explored the influence of caseload on outcome.

Methods

We performed a retrospective observational study using NJR data on 30,814 cemented and 9,708 cementless mobile bearing UKR implanted between 2004 and 2016. Logistic regression was utilised to calculate propensity scores allowing for matching of cemented and cementless groups for various patient, implant and surgical confounders, including surgeon's caseload, using a one to one ratio. 14,814 UKRs (7407 cemented and 7407 cementless) were propensity score matched. Outcomes studied were revision, defined as removal, addition or exchange of a component, and reasons for revision. Implant survival was compared using Cox regression models and groups were stratified according to surgeon caseload.


C. A. F. Dodd D. W. Murray

Introduction

The commonest causes of revision of Unicompartmental Knee Replacement (UKR) in National Registers are loosening and pain. Cementless UKR was introduced to address loosening and was found, in small randomised studies, to have better radiographic fixation than Cemented UKR. Although non-significant these studies also suggested the clinical outcome was better with cementless. The aim of this larger study was to compare the pain and function of cementless and cemented UKR at five years.

Methods

263 Cemented and 266 Cementless UKR of identical design, implanted by four high volume surgeons for the same indications, were reviewed by independent physiotherapists at five years. Revision, re-operation, Oxford Knee Score (OKS), American Knee Society score (AKSS) and EQ-5D were assessed. Two pain specific scores were also used: Pain Detect (PD) and Intermittent and Constant Osteoarthritis Pain (ICOAP). The pain scores were normalised onto a scale of 0 to 100 with 100 being the best. The cemented cohort was mainly implanted before the cementless, although there was considerable overlap. To explore whether differences were due to progressive improvement in surgical practice with time each cohort was divided into early and late subgroups.


W. B. Johnson C. A. Engh W. G. Hamilton N. L. Parks H. Ho K. B. Fricka

Introduction

It has been hypothesized that a unicompartmental knee arthroplasty (UKA) is more likely to be revised than a total knee (TKA) because conversion surgery to a primary TKA is available. The purpose of this study was to determine if there is a lower threshold for UKA revisions compared to TKA revisions based on Oxford Knee Scores and range of motion (ROM).

Methods

We retrospectively reviewed 636 aseptic revision cases performed between 1998 and 2018. This included 137 UKAs that underwent conversion to TKA and 499 TKA revisions. Pre-revision age, body mass index (BMI), time in situ, Oxford Knee Scores, and ROM were available for all patients. T-tests were performed to determine if significant differences existed between the two groups. The minimal clinically important difference (MCID) when comparing Oxford scores between cohorts has been reported as 5 points.


C. M. Lawrie L. C. Okafor G. S. Kazarian T. N. Barrack R. L. Barrack R. M. Nunley

Background

The purpose of this study was to assess the overall clinical and radiographic outcomes of unicompartmental knee arthroplasty (UKA) in the 2–10 year postoperative period. The secondary goal was to compare outcomes between fixed- (FB) and mobile-bearing (MB) implant designs.

Methods

We performed a retrospective analysis of 237 consecutive primary medial UKAs from a single academic center. All cases were performed by high-volume fellowship-trained arthroplasty surgeons, though UKA comprised <10% of their overall knee arthroplasty practice (<20 medial UKAs per surgeon per year). Clinical outcomes included the Oxford Knee Scores (OKS) and revision rates. Femoral and tibial coronal and sagittal angles (FCA, FSA, TCA, TSA) were radiographically measured. FCA (>±10º deviation from the neutral axis), FSA (>15º flexion), TCA (>±5º deviation from the neutral axis), and TSA (>±5º deviation from 7º) outliers were defined. Far outliers were defined as measurements that fell an additional >±2º outside of these ranges. Outcomes were compared between the FB and MB groups.


M. E. Berend D. Gerow

Introduction

The purpose of this study was to use patient generated digital surveillance PROM's to track outcomes of TKA, Medial PKA, Lateral PKA.

Methods

From Aug 2018 until June 2019 we performed 873 knee arthroplasties. Of these, 41 were fixed bearing lateral partial knee replacements (5%), 309 medial partial knee replacements (35%), and 523 total knee replacements (60%). The average age was 65 years old and 59% were female. KOOS-Jr scores were recorded preoperatively, and 6, 12 months postoperatively using digital surveillance technology with a greater than 90% response rate.


B. A. Masri T. Zamora D. S. Garbuz N. V. Greidanus

Introduction

The number of medial unicompartmental knee replacements (UKR) performed for arthritis has increased and as such, revisions to total knee replacement (TKR) is increasing. Previous studies have investigated survivorship of UKR to TKR revision and functional outcomes compared to TKR to TKR revision, but have failed to detail the surgical considerations involved in these revisions. Our objectives are to investigate the detailed surgical considerations involved in UKR to TKR revisions.

Methods

This study is a retrospective comparative analysis of a prospectively collected database. From 2005 to 2017, 61 revisions of UKR to TKR were completed at a single center. Our inclusion criteria included: revision of UKR to TKR or TKR to TKR with minimum 1 year follow-up. Our exclusion criteria include: single component and liner revisions and revision for infection. The 61 UKR to TKR revisions were matched 2:1 with respect to age, ASA and BMI to a group of 122 TKR to TKR revisions. The following data was collected: indication for and time to revision, operative skin to skin surgical time, the use of specialized equipment (augment size/location, stem use), intraoperative and postoperative complications, re-operations and outcome scores (WOMAC, Oxford 12, SF 12, satisfaction score).


F. Catani A. Ensini F. Zambianchi A. Illuminati N. Matveitchouk

Introduction

Robotic technology has been applied to unicompartmental knee arthroplasty (UKA) in order to improve surgical precision in prosthetic component placement, restore knee anatomic surfaces, and provide a more physiologic ligament tensioning throughout the knee range of motion. Recent literature has demonstrated high reliability of robotic-arm assisted UKA in component placement and executing a soft-tissue tensioning plan, with excellent short-term survivorship. Few studies have investigated survivorship and patients' satisfaction at longer follow-ups. Therefore, the purpose of the present study was to determine the survivorship, clinical results and patients' satisfaction of robotic-arm assisted UKAs at a mid-term follow-up, with a minimum of 5 years of follow-up.

Methods

The present retrospective study includes 252 patients (260 knees) who underwent robotic-arm assisted fixed bearing metal backed UKAs at a single centre between April 2011 and July 2013. The mean age at surgery was 66.2 years (SD 8.6). Post-operatively, patients were administered the Forgotten Joint Score-12 (FJS) and asked about their satisfaction level after knee surgery (grade from 1 to 5). Post-operative complications were recorded. Failure mechanisms, revisions and reoperations were also assessed. Kaplan-Meier survival curves were calculated, considering reoperation for all causes and revision as the events of interest.


N. S. Houston A. Star W. J. Hozack

Introduction

Our purpose is to analyze the true costs associated with preoperative CT scans performed for robotic assisted TKA planning and also to determine the value of a formal radiologist reading of these studies.

Methods

We reviewed 194 CT scans of 176 sequential patients who underwent primary RTKA by a single surgeon at a suburban teaching hospital. CT radiology reports were reviewed for the presence of incidental findings that might result in change of care to the patient. Actual payments for technical and professional components of the CT scans were retrieved for 170 of the 176 patients. Any patient payments for the CT scan were also recorded.


T. Kinsey A. F. Chen W. J. Hozack M. A. Mont F. Orozco O. M. Mahoney

Introduction

Component position and overall limb alignment following total knee arthroplasty (TKA) have been shown to influence prosthetic survivorship and clinical outcomes1. The objective of this study was to compare the accuracy to plan of three-dimensional modeled (3D) TKA with manual TKA for component alignment and position.

Methods

An open-label prospective clinical study was conducted to compare 3D modeling with manual TKA (non-randomized) at 4 U.S. centers between July 2016 and August 2018. Men and women aged > 18 with body mass index < 40kg/m2 scheduled for unilateral primary TKA were recruited for the study. 144 3DTKA and 86 manual TKA (230 patients) were included in the analysis of accuracy outcomes. Seven high-volume, arthroplasty fellowship-trained surgeons performed the surgeries. The surgeon targeted a neutral (0°) mechanical axis for all except 9 patients (4%) for whom the target was within 0°±3°. Computed tomography (CT) scans obtained approximately 6 weeks post-operatively were analyzed using anatomical landmarks to determine femoral and tibial component varus/valgus position, femoral component internal/external rotation, and tibial component posterior slope. Absolute deviation from surgical plan was defined as the absolute value of the difference between the CT measurement and the surgeon's operative plan. Smaller absolute deviation from plan indicated greater accuracy. Mean component positions for manual and 3DTKA groups were compared using two-sample t tests for unequal variances. Differences of absolute deviations from plan were compared using stratified Wilcoxon tests, which controlled for study center and accounted for skewed distributions of the absolute values. Alpha was 0.05 two-sided. At the time of this report, CT measurements of femoral component rotation position referenced from the posterior condylar axis were not yet completed; therefore, the current analysis of femoral component rotation accuracy to plan reflects one center that exclusively used manual instruments referencing the transepicondylar axis (TEA).


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B. N. Stulberg J. D. Zadzilka S. Kreuzer W. J. Long Y. D. Kissin R. A. Liebelt V. Campanelli J. Zuhars

Introduction

Active robotics for total knee Arthroplasty (TKA) uses a CAD-CAM approach to plan the correct size and placement of implants and to surgically achieve planned limb alignment. The TSolution One Total Knee Application (THINK Surgical Inc., Fremont, CA) is an open-implant platform, CT-based active robotic surgical system. A multi-center, prospective, non-randomized clinical trial was performed to evaluate the safety and effectiveness of robotic-assisted TKA using the TSolution One Total Knee Application. This report details the findings from the IDE.

Methods

Inclusion criteria for patients receiving robotic TKA were: primary unilateral TKA; Kellgren-Lawrence OA grade 3 or 4; BMI < 40 kg/m2; coronal plane deformity < 20° varus; sagittal flexion contracture < 15°. In addition to monitoring all adverse events (AE), a pre-defined list of relevant major AEs were specifically identified to evaluate safety (Healy et al, 2013): medial collateral ligament injury; extensor mechanism disruption; neural deficit; periprosthetic fracture; patellofemoral dislocation; tibiofemoral dislocation; and vascular injury. Bleeding complications were also assessed. Malalignment rate, defined as the percentage of patients with more than a ± 3° difference in varus-valgus alignment from the preoperative plan, was used to determine accuracy of the active robotic system. Knee Society Scores (KSS) and Short Form 12 (SF-12) Health Surveys were assessed as clinical outcome measures. For each outcome, results were compared to published values associated with manual TKA.


M. B. Held M. J. Grosso A. Gazgalis N. O. Sarpong E. Jennings R. P. Shah H. J. Cooper J. A. Geller

Introduction

Robotic-assisted total knee arthroplasty (TKA) was introduced to improve limb alignment, component positioning, and soft-tissue balance, yet the effect of adoption of this technology has not been established. This study was designed to evaluate whether robotic-assisted TKA leads to improved patient reported outcome measures (PROMs) and patient satisfaction as compared to conventional TKA at 3 and 12 months.

Methods

This IRB-approved single-surgeon retrospective cohort analysis of prospectively collected data compared 113 conventional TKA patients with 145 imageless robotic-assisted TKA patients (Navio™ Surgical System, Smith&Nephew®, Memphis TN). Basic demographic information, intraoperative and postoperative data, and PROMs (SF-P, SF-M, WOMAC pain, WOMAC stiffness, WOMAC Physical Function, KSS) were collected and recorded preoperatively, at 3 months, and at 12 months following surgery. Range of motion (ROM), blood loss, surgical duration, and complication rates between groups were also collected. Continuous measures such as mean difference in PROMs and ROM were compared using unpaired t-tests. Categorical measures such as the percentage of patients with complications were compared using chi-square analysis.


C. L. Cool D. A. Gregory C. J. Lavernia

Introduction

Previous studies on Medicare populations have shown improved outcomes and decreased 90-day episode-of-care costs with robotic assisted total knee arthroplasty (rTKA). The purpose of this study was to evaluate the expenditures and utilization following rTKA in the under 65 y/o population.

Methods

TKA procedures were identified using the OptumInsights Inc. database. A two-year window was studied. The procedures were stratified in two groups: the rTKA or manual (mTKA) cohorts. Propensity score matching (PSM) was performed at 1:5. Utilization and associated costs were analyzed for 90 days following the index procedure. 357 rTKA and 1785 mTKA were included in this analysis.


N. A. Bedard D. E. DeMik C. N. Carender J. A. Browne R. Schwarzkopf J. J. Callaghan

Introduction

In 2015, the healthcare system transitioned from International Classification of Diseases, Ninth Revision (ICD-9) coding to the Tenth Revision (ICD-10). Given that administrative claims are used for quality initiatives, risk adjustment models and clinical research, we sought to determine the effect of new, more detailed coding on the incidence of complications following primary total knee arthroplasty (TKA).

Methods

The Humana administrative claims database was queried from 2-years prior to October 1, 2015 (ICD-9 cohort) and for 1-year after this date (ICD-10 cohort) to identify all primary TKA procedures. Each TKA was then tracked for occurrence of an arthroplasty specific post-operative complication within 6 months of surgery using the respective coding systems. Laterality and joint specific codes were utilized for the ICD-10 cohort to ensure complications occurred on the same side and joint as the index procedure. Incidence of each complication was compared between cohorts using risk ratios (RR) and 95% confidence intervals.


N. Sodhi R. M. Vakharia H. K. Anis J. O. Ehiorobo L. Garbarino P. Gold M. W. Roche M. A. Mont

Introduction

Emergency department (ED) visits following primary total knee arthroplasty (TKA) can lead to poor patient satisfaction, potentially unnecessary readmissions, and greater overall healthcare costs. Reasons for post-operative ED visits are often entirely medical in nature and can be independent of the recent operation. Several strategies have been developed to help reduce ED visits. However, one major factor that can play a critical role in addressing potentially avoidable visits is provider and patient education. A major factor that can play a crucial role in addressing potentially avoidable visits is provider and patient education. It follows that a thorough understanding of which patients are visiting the ED and why can help in avoiding the visits. Therefore, the purpose of this study was to investigate: 1) causes and 2) patient-related factors (demographics and comorbidities) associated with ED visits following primary TKA.

Methods

A national private payer database was queried for primary TKAs performed between 2007 and 2016 using the International Classification of Disease, ninth revision (ICD-9) procedural code 81.54. ED visits were identified using Current Procedural Terminology (CPT) codes 99281 to 99285. Patients with 90-day ED visits were in the study group (n=28,044) whereas those without 90-day ED visits served as controls (n=82,289). Causes for ED visits were divided into cardiopulmonary, gastrointestinal, renal, thromboembolic, leg pain, or wound-related. Patient demographics and risk factors assessed included age, gender, and body mass index (BMI) as well as several comorbidities (Table 1). Pearson's chi-square tests were performed to compare patient demographics and comorbidities between the cohorts. In order to adjust for potential confounders, multivariate binomial logistic regression analysis was performed to further evaluate the associations between patient factors and 90-day ED visits. A p-value less than 0.01 was considered statistically significant.


M. Sloan N. P. Sheth C. L. Nelson

Introduction

Rates of readmission and reoperation following primary total knee arthroplasty (TKA) are under scrutiny due to new payment models, which penalize these negative outcomes. Many prior studies have demonstrated the risk of perioperative complications among patients with obesity. However, an elevated complication rate among patients with poor nutrition, as measured by hypoalbuminemia, has also been reported. We sought to determine whether controlling for hypoalbuminemia would mitigate the effect that prior authors had identified in patients with obesity. In addition, we hoped to identify an albumin threshold above which risk of readmission and reoperation would be minimized.

Materials and Methods

We reviewed the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database for the period of 2008–2016 to evaluate the rates of perioperative complications among primary TKA patients by obesity category and albumin level. Patients were divided into groups according to World Health Organization obesity category and continuous as well as dichotomous albumin level. The primary outcomes were readmission and reoperation within 30 days of surgery. Patients without BMI or albumin data were excluded, as were patients undergoing surgery for the treatment of fracture or bone tumor. Univariate logistic regression compared predictive value of body mass index and albumin on incidence of these outcomes, using the normal weight and albumin > 3.5 g/dL groups as controls. Multivariate logistic regression modeling controlled for age, gender, and comorbidity status. Receiver operator curves (ROC) were generated to determine if an albumin threshold could be determined, above which risk for these complications would be minimized.


L. Nowak E. H. Schemitsch

Introduction

We designed this study to compare 30-day complications and length of hospital stay between patients undergoing total knee arthroplasty (TKA) with general anesthesia, to those undergoing TKA with spinal, epidural anesthesia, or Monitored Anesthesia Care (MAC, a combination of local anesthesia with sedation and analgesia provided by an anesthesiologist) with or without regional nerve blocks.

Methods

We identified patients ≥18 years undergoing TKA between the years of 2006 and 2017 from the American College of Surgeons National Surgical Quality Improvement Program (NSQIP). We collected patient demographics, anesthesia type, 30-day complications, length of operation and hospital stay from the database. We used multivariable regression to compare complications and length of stay (LOS) between anesthesia types, while adjusting for relevant covariables


S. Thirunavukkarasu R. J. Sierra Z. El-Zoghby

Introduction

Patients with solid organ transplant have been shown to have increased risk of complications following TKA compared to non-transplant patients. The risk of AKI in KTx is reported to be as high as 15.6 % and associated with increased morbidity, and length of stay (LOS). Our aim was to determine the incidence of AKI in KTx undergoing primary and revision TKA and to identify risk factors for its occurrence and its effect on allograft function 1 year postoperatively.

Methods

Using the orthopedic and transplant databases we designed a case-control study of 82 patients undergoing 101 TKA between 2000 and 2018 at our institution. The average age at surgery was 65 years (range 35–83); 58% male and 98% white. AKI was defined per KIDGO guidelines.


J. M. Jennings M. Mejia M. A. Williams R. M. Johnson C. C. Yang D. A. Dennis

Background

Optimal perioperative fluid management has not been established in patients undergoing orthopaedic surgical procedures. Our purpose was to investigate the effects of perioperative fluid management on patients experiencing TKA.

Methods

One hundred thirty patients who met inclusion criteria undergoing primary unilateral TKA were prospectively randomized into traditional (TFG) vs. oral (OFG) perioperative fluid management groups. The TFG had a predetermined (4L) amount of intravenous fluids (IVF) administered in the perioperative period. The OFG began drinking a minimum of three, 20-ounces servings of clear fluids daily for three days prior to surgery. This cohort also drank 10-ounces of clear fluids 4 hours prior to surgery. Perioperative IVF were discontinued when the patient began oral intake or when the total amount of IVF reached 500mL. Outcome measures included: body-weight (BW) fluctuations, knee motion, leg girth, bioelectrical impendence, quadriceps activation, functional outcomes testing, KOOS JR, VR-12, laboratory values, vital signs, patient satisfaction, pain scores, and adverse events.


K. R. Berend A. V. Lombardi D. A. Crawford J. M. Hurst M. J. Morris

Introduction

A smartphone-based care platform allows a customizable educational and exercise interface with patients, allowing many to recover after surgery without the need for formal physical therapy (PT). Furthermore, advances in wearable technology to monitor physical activity (PA) provides patients and physicians quantifiable metrics of the patient's recovery. The purpose of this study is to determine the feasibility of a smartphone-based exercise educational platform after primary knee arthroplasty as well as identifying factors that may predict the need for formal physical therapy.

Methods

This study is part of a multi-institution, prospective study of patients after primary total knee arthroplasty (TKA) and partial knee arthroplasty (PKA) enrolled in a smartphone with smartwatch-based episode of care platform that recorded multimodal PA (steps, kcal, stairs). Postoperatively, all patients initially followed the smartphone-based exercise program. At the surgeon's discretion, patients were prescribed therapy if needed. The outcome of this study was the need for PT outside the app-based exercise program as well as time to return to preoperative step count. Variables assessed were preoperative weekly step counts (steps/day), weekly postoperative activity level (weekly step count compared to preoperative level), compliance with the exercise program (>75% completion) and patient demographic data including gender, age, BMI and narcotic use. One hundred eighty-eight patients were included in analysis: 45 PKA (24%) and 143 TKA (76%). Step count data was available on 135 patients and physical therapy data on 174.


D. A. Hu R. E. Harold B. L. Woeltjen S. D. Stulberg

Introduction

Total Knee Arthroplasty (TKA) has been demonstrated to drastically improve a patient's quality of life. The outcomes following TKA are often reported by subjective patient reported outcome measurements (PROMs). However, there are few objective outcome measures following TKA, limiting the amount of information physicians can use to effectively guide a patient's recovery, especially in the first 3 weeks. Newly developed knee sensors have been able to ameliorate this problem by providing the physician with previously unobtainable objective data. Our study aims to evaluate the use of a wearable knee sensor device to measure functional outcomes (range of motion and steps) in real time.

Methods

29 patients who underwent primary, unilateral TKA were recruited for this IRB approved study. Patients were instructed how to use the device and associated mobile phone application preoperatively (Figure 1) and provided knee sensors to wear postoperatively (Figure 2). Patients wore the device for 3 weeks postoperatively to allow for data collection. The device recorded range of motion, number of steps, and percentage of physical therapy exercises completed. Patients were grouped by gender, age (<69 or >=70 years old), and BMI (<30 and >=30 kg/m2) for analysis of functional outcome measurements (maximum flexion, minimum extension, and number of steps). Unpaired two-sample t-tests were used to analyze differences between the groups.


M. J. Kraay S. Fitzgerald

Introduction

Employer-sponsored travel surgery programs for commonly performed procedures like total joint arthroplasty (TJA) are increasing, as employers try to more effectively manage the healthcare costs of their employees. This new approach by employers to direct their employees to designated “Centers of Excellence” (COEs) creates a need to characterize the “travel patient” population that commutes long distances to receive their surgical care and returns home for their rehab shortly after surgery. Electronic patient rehabilitation platforms (EPRA) facilitate communication, patient navigation, and care coordination across this complex episode of care and may contribute to improved outcomes after TJA. The aim of this study is to evaluate patient satisfaction, functional outcomes and engagement with the use of an EPRA among two TJA cohorts: 1) travel and 2) non-travel TJA patients.

Methods

A retrospective review was performed on total knee (TKA) and total hip (THA) arthroplasty patients at a single institution during the first 6 months following implementation of an EPRA. All patients were offered internet based access to an EPRA which provided instant messaging with the care team, algorithmic navigation of the patient during the pre and post-op phases, and access to an extensive library of educational videos regarding their surgery, rehab, and FAQs. Primary outcome measures were the pre-op and 12 week post op HOOS Jr. and KOOS Jr. Patient satisfaction at 12 weeks after surgery and engagement metrics for the EPRA were also examined. Cases were separated into two groups: travel and non-travel, and the groups were compared in terms of engagement, improvement in functional outcomes, and patient satisfaction. Chi-square test and t-test statistics were used for analysis.


M. J. Halawi W. Jongbloed S. Baron L. Savoy M. P. Cote J. R. Lieberman

Introduction

Patient reported outcome measures (PROMs) are increasingly used as quality benchmarks in total joint arthroplasty (TJA). The objective of this study was to investigate whether PROMs correlate with patient satisfaction, which is arguably the most important and desired outcome.

Methods

An institutional joint database was queried for patients who underwent primary, elective, unilateral TJA. Eligible patients were asked to complete a satisfaction survey at final follow-up. Correlation coefficients (R) were calculated to quantify the relationship between patient satisfaction and prospectively collected PROMs. We explored a wide range of PROMs including Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC); Short Form-12 (SF-12), Oxford Hip Score (OHS), Knee Society Clinical Rating Score (KSCRS), Single Assessment Numerical Evaluation (SANE), and University of California Los Angeles activity level rating (UCLA).


J. B. Meding L. K. Meding R. M. Meneghini R. A. Malinzak

Introduction

Maintaining posterior stability in total knee arthroplasty (TKA) may be achieved by using a posterior stabilized TKA, retaining and balancing the posterior cruciate ligament (PCL) using a traditional cruciate-retaining design (CR), or by increasing the sagittal plane conformity of the tibial insert. In the latter case, stability is achieved by the addition of an anterior buildup on the tibial polyethylene creating the so-called “anterior stabilized” (AS) design. We hypothesized that using an AS tibial insert would provide similar function and survivorship as compared to using a more traditional CR bearing when the PCL is either recessed or balanced.

Methods

Between 2004 and 2016, 1,731 modular CR TKAs were implanted in 1,509 patients using the same CR TKA design. The diagnosis was osteoarthritis in 98%. 58% of patients were female. Average age of 64.9 years. Within this group, 868 TKAs (50.1%) had a standard CR tibial bearing (3-degree posterior slope and no posterior lip) implanted (CR-S). 480 TKAs (27.8%) had a lipped CR modular tibial bearing (2.5 mm elevated posterior lip) implanted (CR-L). Starting in 2013, 383 TKAs (22.1%) were implanted with an AS modular tibial bearing (9–11 mm anterior lip and a 5 mm posterior lip). If the PCL was considered non-functional or absent, an AS bearing was placed. If the PCL was considered functional, a standard bearing or lipped bearing was used. Clinical and radiographic analysis was performed according to the Knee Society (KS) grading system. The most recent clinical and radiographic evaluation was used for post-operative analysis. The average follow-up in the entire cohort of TKAs was 5.5 years (range 2 to 14.3 years). Kaplan-Meier analysis was used to determine prosthesis survivorship with failure defined as aseptic loosening of the prosthesis (with or without revision) or tibial insert exchange.


A. T. Livermore J. Erickson M. Hickerson C. L. Peters

Introduction

Total knee arthroplasty (TKA) reliably improves pain and function in patients with knee osteoarthritis (OA), though a substantial percentage of patients remain unsatisfied. Reasons include the presence of complications, persistent pain, and unmet expectations. The aim of this study was to determine whether the sequential addition of accelerometer-based navigation of the distal femoral cut and sensor-assisted soft tissue balancing changed complication rates, radiographic alignment, or patient-reported outcomes (PROs) compared to TKA performed with conventional instrumentation.

Methods

This retrospective cohort study included 371 TKAs in 319 patients. All surgeries were performed by a single surgeon in sequential fashion using a measured resection technique with a goal of mechanical alignment. The historical control group, utilizing intramedullary guides for distal femoral resection and surgeon-guided soft tissue balancing, was compared to group 1 (accelerometer-based navigation for distal femoral resection, surgeon-guided balancing) and group 2 (navigated femoral resection, sensor-guided balancing). Primary outcome measures were PROMIS scores including physical function computerized adaptive test (PF CAT), and the Global 10 health assessment (including physical, mental, and pain scores), and Knee Injury Osteoarthritis and Outcome Score (KOOS), measured preoperatively and at 6 weeks and 12 months postoperatively. Radiographic measurements included component position and overall mechanical alignment of the limb and were made at 6 weeks by a single examiner from hip to ankle standing films. Charts were reviewed for pre- and postoperative ROM at 6 weeks, polyethylene insert morphology, and postoperative hematocrit change. Complications were recorded, including manipulation under anesthesia and reoperation. Our study was powered to detect a difference of 1 standard deviation in PF CAT score with 100 patients. Statistical analysis was performed by a statistician including t-tests, multivariate regression, and time series plot analyses.


I. Livshetz N. Mohamed P. V. Papas R. E. Delanois M. A. Mont G. R. Scuderi

Background

As the number of total knee arthroplasties (TKA) being performed continues to increase, the number of potential failures requiring revision surgery would also be expected to increase. This study analyzed the trends in revision TKA (rTKA) from 2009 to 2016.

Methods

The Nationwide Inpatient Sample (NIS) database was used to identify all rTKA by International Classification of Diseases, Ninth Revision (ICD-9) and Tenth Revision (ICD-10) codes. The diagnoses leading to revision, revision costs, patient and hospital characteristics, and major inpatient complications were compared between 2009 and 2016. Multivariate logistic regression analyses were used to calculate odds ratios (OR) for complications.


D. F. Dalury D. M. Chapman M. J. Miller

Introduction

Enhanced pain and rehabilitation protocols have significantly improved patient recovery following primary TKR. Little has been written on how the protocols have affected the revision TKR patient. We report on a matched group of revision and primary TKR patients treated with the identical pain and rehab program.

Materials and Methods

40 aseptic RTKR patients who underwent a full femoral and tibial revision were matched by age, sex, and BMI to a group of patients who underwent a cemented tri-compartmental primary TKR. All revision knees had uncemented stemmed femurs and tibias. All 40 patients had either a metaphyseal sleeve on either the femur or tibia or both. Patients in both groups were treated with an identical post op pain protocol (Spinal anesthetic, local infiltrative analgesia and multimodal oral pain management along with rapid rehabilitation). All patients were mobilized on POD1 and allowed weight bearing as tolerated. Patients were followed for a minimum of 1 year. KSS at 6 weeks and 1 year were recorded for both groups.


J. R. Martin M. B. Geary M. Ransone D. Macknet K. Fehring T. K. Fehring

Introduction

Tibial component loosening is a frequent cause of failure in primary total knee arthroplasty (TKA). Management options include isolated tibial component revision or full component revision. A full component revision is frequently selected by surgeons who are unfamiliar with the existing implant or have a “let's just start over attitude.” This option adds morbidity versus isolated tibial exchange. While isolated tibial exchange has lower morbidity, it is technically more challenging with regard to exposure and maintaining prosthetic stability. This study was designed to compare these two reconstructive options.

Methods

Patients revised for isolated aseptic tibial loosening were identified from 2012–2017. Patients with revision implants, or those revised for infection, instability, osteolysis, or femoral component loosening were excluded. 161 patients met these criteria, 85 patients had an isolated tibial revision and 76 had revision of both components despite having only a loose tibial component. Patient demographics as well as clinical and radiographic outcomes were recorded for each cohort.


Y. Warchawski S. Garceau O. Dahduli J. I. Wolfstadt D. Backstein

Background

Patellar dislocation is a serious complication leading to patient morbidity following total knee arthroplasty. The cause can be multifactorial. Extensor mechanism imbalance may be present and result from technical errors such as malrotation of the implants.

Methods

We performed a retrospective study assessing the outcomes of revision surgery for patellar dislocation in patients with component malrotation in both primary and revision total knee arthroplasty. Patient demographics, etiology of dislocation, presurgical deformity, intraoperation component position, complications, reoperation and knee society scores were collected.


M. W. Tetreault K. I. Perry M. W. Pagnano A. D. Hanssen M. P. Abdel

Introduction

Metaphyseal fixation during revision total knee arthroplasties (TKAs) is important, but potentially challenging with historical cone designs. Material and manufacturing innovations have improved the size and shape of cones available, and simplified requisite bone preparation. In a very large series, we assessed implant survivorship, radiographic results, and clinical outcomes of new porous 3-D printed titanium metaphyseal cones featuring a reamer-based system.

Methods

We reviewed 142 revision TKAs using 202 cones (134 tibial and 68 femoral) from 2015 to 2016. Sixty cases involved tibial and femoral cones. Most cones (149 of 202; 74%) were used for Type 2B or 3 bone loss. Mean age was 66 years, with 54 % females. Mean BMI was 34 kg/m2. Patients had a mean of 2.4 prior surgeries and 48% had a history of periprosthetic infection. Mean follow-up was 2 years.


N. A. Bedard R. A. Cates D. G. Lewallen A. D. Hanssen D. J. Berry M. P. Abdel

Introduction

Metaphyseal cones with cemented stems are frequently used in revision total knee arthroplasties (TKAs). However, if the diaphysis has been previously violated (as in revision of a failed stemmed implant), the resultant sclerotic canal can impair cemented stem fixation, which is vital for cone ingrowth and long-term fixation. We report the outcomes of our novel solution to this problem, in which impaction grafting and a cemented stem in the diaphysis was combined with an uncemented metaphyseal cone for revision TKAs with severely compromised bone.

Methods

A metaphyseal cone was combined with diaphyseal impaction grafting and cemented stems in a novel fashion for 35 revision TKAs. Mean age at revision TKA was 70 years, with 63% being male. Patients had a mean of 4 prior knee arthroplasty procedures. Indications for the revision with this construct were aseptic loosening (80%) and two-stage re-implantation for periprosthetic infection (PJI; 20%). Mean follow-up was 3 years.


N. D. Heckmann C. R. Nahhas C. J. Della Valle P. H. Yi C. Culvern T. L. Gerlinger D. Nam

Background

In the setting of a “dry” aspiration, saline lavage is commonly used to obtain a sample for analysis. The purpose of this study is to prospectively determine the impact of saline lavage on synovial fluid markers in revision arthroplasty.

Methods

79 patients undergoing revision hip (19) and knee (60) arthroplasty were enrolled. Intraoperatively, prior to arthrotomy, the maximum amount of fluid possible was aspirated to simulate a dry-tap (“pre-lavage”) followed by subsequent injection with 20 mL of normal saline and re-aspiration (“post-lavage”). Pre and post-lavage synovial white blood cell (WBC) count, percent polymorphonuclear cells (%PMN), and cultures were compared. Statistical analyses utilized the Wilcoxon signed-rank test.


K. Goswami J. Parvizi
The Orthopedic Genomics Workgroup

Introduction

Next generation sequencing (NGS) has been shown to facilitate detection of microbes in a clinical sample, particularly in the setting of culture-negative periprosthetic joint infection (PJI). However, it is unknown whether every microbial DNA signal detected by NGS is clinically relevant. This multi-institutional study was conceived to 1) identify species detected by NGS that may predict PJI, then 2) build a predictive model for PJI in a developmental cohort; and 3) validate the predictive utility of the model in a separate multi-institutional cohort.

Methods

This multicenter investigation involving 15 academic institutions prospectively collected samples from 194 revision total knee arthroplasties (TKA) and 184 revision hip arthroplasties (THA) between 2017–2019. Patients undergoing reimplantation or spacer exchange procedures were excluded. Synovial fluid, deep tissue and swabs were obtained at the time of surgery and shipped to MicrogenDx (Lubbock, TX) for NGS analysis. Deep tissue specimens were also sent to the institutional labs for culture. All patients were classified per the 2018 Consensus definition of PJI. Microbial DNA analysis of community similarities (ANCOM) was used to identify 17 candidate bacterial species out of 294 (W-value >50) for differentiating infected vs. noninfected cases. Logistic Regression with LASSO model selection and random forest algorithms were then used to build a model for predicting PJI. For this analysis, ICM classification was the response variable (gold standard) and the species identified through ANCOM were the predictor variables. Recruited cases were randomly split in half, with one half designated as the training set, and the other half as the validation set. Using the training set, a model for PJI diagnosis was generated. The optimal resulting model was then tested for prediction ability with the validation set. The entire model-building procedure and validation was iterated 1000 times. From the model set, distributions of overall assignment rate, specificity, sensitivity, positive predictive value (PPV) and negative predicative value (NPV) were assessed.


W. A. Jiranek B. J. Kildow R. M. Danilkowicz M. P. Bolognesi T. M. Seyler

Introduction

Recent focus has queried whether of deoxyribonucleic acid (DNA) sequencing modalities of bacterial DNA found in periarticular fluid and tissues will improve in periprosthetic joint infection (PJI) diagnosis and organism identification diagnostic accuracy for periprosthetic joint infection The purpose of this study was to compare the diagnostic accuracy of next generation sequencing (NGS) to polymerase chain reaction (PCR) multiplex, and culture, the Musculoskeletal Infection Society (MSIS) criteria, and the recently proposed criteria by Parvizi et al. [1] in the diagnosis of periprosthetic knee infections.

Methods

In this retrospective study, aspirate or tissue samples were collected in 70 revision and 58 primary knee arthroplasties for routine diagnostic workup for PJI and sent to the laboratory for NGS and PCR multiplex. Concordance along with statistical differences between diagnostic studies were calculated using Chi-squared test for categorical data.


C. M. Lawrie S. Jo T. N. Barrack R. L. Barrack

Introduction

Periprosthetic infection (PJI) after primary total knee arthroplasty (TKA) remains a challenging issue affecting 1–2% of cases. Locally delivered prophylactic antibiotics, including tobramycin or gentamicin mixed in polymethylmethacrylate (PMMA) bone cement and vancomycin powder, are increasingly used despite a lack of high quality evidence for either practice. In this study, we report the antibiotic susceptibility of organisms recovered in culture from patients with acute prosthetic joint infection after primary TKA to gentamicin, tobramycin and vancomycin.

Methods

Using a retrospective database of all primary TKA performed at a single institution between January, 1 2014 and July 1, 2018, we identified 18 cases of acute PJI after primary TKA, as defined by the Musculoskeletal Infection Society 2011 guidelines as less than 3 months from symptoms or index surgery to presentation. The use of antibiotic bone cement during the index procedure and time to surgical management of the infection were recorded. Fluid cultures and tissue cultures were obtained intraoperatively at the time of revision. The organisms from positive cultures underwent MIC testing to gentamicin, tobramycin and vancomycin using a gradient diffusion method (ETEST). MIC breakpoints for susceptibility were based on Clinical and Laboratory Standards Institute definitions.


J-N. Argenson M. Ollivier P. Sautet Q. Grisetti M. P. Abdel S. Parratte

Introduction

Periprosthetic joint infection (PJI) remains the main cause of failure in primary and revision total knee arthroplasties (TKAs). Local delivery of antibiotics, mainly antibiotic-loaded bone cement (ALBC), is commonly employed to prevent PJI. Over the past decade, tantalum and porous titanium have been successfully utilized as metaphyseal fixation devices to address bone loss and improve biologic fixation during revision TKA. However, no study has examined the antimicrobial properties compared to bone cement. The purpose of this study was to compare the ability of tantalum, 3D porous titanium, antibiotic-loaded bone cement (ALBC) and smooth titanium alloy (STA) to inhibit Staphylococci bacterial agents in an in vitro medium environment, based on the evaluation of the zone of inhibition (ZOI) and the antibacterial activity duration. Our study hypothesis was that we will found no significant difference between groups to inhibit Methicillin-Sensitive or Methicillin-Resistant Staphylococcus aureus (MSSA/MRSA) agents.

Methods

Thirty beads made of 3 different materials (tantalum/ 3D porous titanium/ STA) were bathed during 1hour inside of a solution made of 1g vancomycin with 20-mL of sterile water for injection (bath concentration: 50 mg/mL). Ten 1cm3 cylinders were also created mixing standard surgical cement with 1g of Vancomycin in standardized sterile molds (ALBC beads). Finally, thirty beads made of tantalum/ 3D porous titanium/ STA were bathed in phosphate buffered saline solution to act as a control group. Cylinders were then placed on agar plates inoculated with MSSA and MRSA. Inhibition zone diameters were measured each day and cylinders were transferred onto a new inoculated plate. Inhibition zones were measured with a manual Vernier caliper and with automated software. The mean inhibition zones between groups were compared using the Wilcoxon Test.


O. K. Muratoglu D. Gil A. Atici R. Connolly S. Hugard E. Oral

Introduction

Infection remains as one of the major challenges of total joint surgery. One-stage irrigation, debridement and reimplantation, or two-stage revision surgery with a temporary implantation of antibiotic eluting bone cement spacer followed by reimplantation are two methods often used to treat infected patients with mixed outcomes. Like bone cement, ultra-high molecular weight polyethylene (UHMWPE) can also be used as a carrier for antibiotics. Recently, we demonstrated that vancomycin and rifampin can be delivered from UHMWPE implants at therapeutic levels to eradicate Staphylococcus aureus biofilm in a lupine animal model. There are regulatory challenges in translating these types of combination devices to clinical use. Last year, at this meeting, we presented the preliminary pre-clinical testing for a temporary UHMWPE spacer containing gentamicin sulfate as a first step towards clinical use. Since then, we carried out a survey among the Knee Society membership about their preference for spacer use in two-stage revision surgery and found that 43% prefer to use a CoCr femoral component on an all-poly cemented tibial insert, 22% prefer bone cement spacers molded in the OR, 20% prefer static bone cement spacers, and 14% prefer pre-formed bone cement spacers. We modified our implant design based on the majority's preference for a total knee system, rather than bone cement spacers, in the temporary two-stage approach. In this study, we explored the effect of gentamicin sulfate (GS) elution from UHMWPE/GS tibial inserts on bacterial colonization on CoCr surfaces.

Methods

We characterized the gentamicin sulfate (GS) particles with scanning electron microscopy (SEM). We molded UHMWPE/GS powder blends and characterized the morphology using SEM and Energy Dispersive X-Ray Spectroscopy (EDS). We submerged samples of molded UHMWPE/GS in buffered phosphate solution (PBS) at 37°C and quantified the extent of GS elution into PBS with a method described by Gubernator et al. using o-phthaladehyde (OPA) [1]. Under basic conditions, OPA reacts with primary amino groups to form fluorescent complexes. Since gentamicin is the only source of such amino acids in our elution samples, the number of fluorescent complexes formed is directly proportional to the amount of gentamicin in the sample. Using this method, we could quantify gentamicin elution by measuring sample fluorescence post OPA-reaction. We used a plate reader to excite the fluorescent complexes formed in the OPA reaction and measured the resulting emission at wavelengths of 340 nm and 455 nm, respectively. We also quantified the effect of the standard cleaning protocol (heated sonication in alkaline water and alcohol) used to clean UHMWPE implants on subsequent GS elution from UHMWPE/GS samples using the OPA method. We used agar diffusion tests to characterize antibacterial properties of UHMWPE/GS samples after cleaning. For these tests, we collected eluents collected from UHMWPE/GS and gentamicin-impregnated bone cement (BC/GS) following 1, 2, 3, and 4 weeks of elution, and tested against S. aureus (ATCC 12600). We used the “daughter cells” method developed by Bechert et al. to assess anticolonizing properties of UHMWPE/GS [2,3]. We also characterized the colonization of bacteria on CoCr surfaces in the presence of GS eluting from UHMWPE/GS test samples. For this we modified a Pin-on-Disc (PoD) wear tester: An UHMWPE/GS pin and UHMWPE pin (control) articulated against an implant-finish CoCr disc with Tryptic Soy Broth containing S. Aureus as the lubricant. After 18 hrs, we rinsed the articular surfaces of the pin and disc and stamped them onto Agar gel to transfer any adherent bacteria. We incubated the Agar plate overnight such that adherent bacteria proliferated and became visible.


C. R. Nahhas P. N. Chalmers J. Parvizi S. M. Sporer K. R. Berend M. Moric A. F. Chen M. Austin G. K. Deirmengian M. J. Morris C. Culvern C. J. Della Valle

Background

The purpose of this multi-center, randomized clinical trial was to compare static and articulating spacers in the treatment of PJI complicating total knee arthroplasty TKA.

Methods

68 Patients treated with two-stage exchange arthroplasty were randomized to either a static (32 patients) or an articulating (36 patients) spacer. A power analysis determined that 28 patients per group were necessary to detect a 13º difference in range of motion between groups. Six patients were excluded after randomization, six died, and seven were lost to follow-up prior to two years.


M. A. Hartzler K. Li M. Geary S. M. Odum B. D. Springer

Introduction

Two-stage exchange arthroplasty remains the gold standard for treatment of PJI with reported success rates of 85–90%. Complications that occur during treatment are often not reported or considered in the success rate. The purpose of this study was to analyze complications in patients undergoing two-stage exchange and determine when they occur.

Methods

We analyzed all patients that underwent two-stage exchange arthroplasty for treatment of chronic PJI of the knee from 2010 to 2018. We categorized complications as medical vs. surgical. The intervals for complications were divided into: interstage, early post re-implant (3 months) and late post re-implant (3 months to minimum 1 year). Minimum follow-up to evaluate complications was one year.


B. P. Chalmers A. K. Matrka S. A. Sems M. P. Abdel R. J. Sierra A. D. Hanssen M. W. Pagnano T. M. Mabry K. I. Perry

Introduction

While knee arthrodesis is a salvage option for recalcitrant total knee arthroplasty (TKA) periprosthetic joint infection (PJI) it is used relatively uncommonly and contemporary data are limited. We sought to determine the reliability, durability and safety of knee arthrodesis as the definitive treatment for complex, persistently infected TKA in a modern series of patients.

Methods

We retrospectively identified 41 knees treated from 2002–2016 with a deliberate, two-stage knee arthrodesis protocol (TKA resection, high-dose antibiotic spacer, targeted IV antibiotics and followed by subsequent knee arthrodesis) in patients with complex TKA PJI. Mean age was 64 years & mean BMI was 39 kg/m2. Mean follow-up was 4 years. The extensor mechanism was deficient in 66% of knees, and flap coverage was required in 34% of knees. The majority of patients were host grade B (56%) or C (29%), and extremity grade of 3 (71%). Twenty-nine percent had poly-microbial infections, and 49% had multi-drug resistant organisms. Fixation included intramedullary nail (61%), external fixator (24%), and dual plating (15%).


G-C. Lee D. Colen L. S. Levin S. Kovach

Introduction

Infection following TKA can be a catastrophic complication that can cause significant pain, morbidity and jeopardize limb viability. The integrity of the soft tissue envelope is critical to successful treatment and infection control. While local tissue flaps can provide adequate coverage for most soft tissue defects around the knee, there are cases that require salvage using microvascular free tissue transfers. The purpose of this study is to evaluate the 1) rate of limb salvage; 2) infection control; and 3) clinical function following free flap coverage for salvage of the infected TKA.

Materials and Methods

We retrospectively reviewed 23 microvascular free tissue transfers for management of soft tissue defects in infected TKA. There were 16 men and 7 women with a mean age of 61.2 years (range 39–81). The median number of procedures performed prior to soft tissue coverage was 5 (range 2–9) and all patients had failed at least one 2 stage reimplantation procedure. Clinical outcomes were measured using the Knee Society Scoring system for pain and function. The rate of limb salvage and infection control were recorded.


R. Iorio C. L. Barnes M. Vitale J. I. Huddleston D. Haas

Introduction

In November 2017, the Center for Medicare and Medicaid Services (CMS) finalized the 2018 Medicare Outpatient Prospective Payment System rule that removed total knee arthroplasty (TKA) procedures from the Medicare inpatient-only (IPO) list of procedures. This action had significant and unexpected consequences.

For several years, CMS has utilized a rule called the “Two-Midnight Rule” to define outpatient status for all procedures not on the IPO list. CMS made TKA subject to the “Two-Midnight Rule” in conjunction with the decision to move TKA off the IPO list. According to the “Two-Midnight Rule,” a hospital admission should be expected to span at least two midnights in order to be covered as an inpatient procedure. If it can be reliably expected that the patient will not require at least two midnights in the hospital, the “Two-Midnight Rule” suggests that the patient is considered an outpatient and is therefore subject to outpatient payment policies. Under prior guidance related to the “Two-Midnight Rule;” however, CMS also states that Medicare may treat some admissions spanning less than two midnights as inpatient procedures if the patient record contains documentation of medical need. The final rule was clear in stating CMS's expectation was that the great majority of TKAs would continue to be provided in an inpatient setting.

Methods

We looked at 3 different levels of the IPO rule impact on TKA for Medicare beneficiaries: a national comparison of fee for service (FFS) inpatient and outpatient classification for 2017 vs 2018; a survey of AAHKS surgeons completed in April of 2019; and an in-depth analysis of a large academic medical center experience. An analysis of change in inpatient classification of TKA patients over time, number of Quality Improvement Organization (QIO) audits, compliance solutions of organizations for the new rule and cost implications of those compliance solutions were evaluated.


C. L. Barnes D. Haas J. I. Huddleston R. Iorio

Introduction

The Centers for Medicare and Medicaid Services (CMS) removed total knee arthroplasty (TKA) from inpatient-only status in 2018. Our goal was to measure the adoption of outpatient TKAs, the impact on re-treatment rates, and the economic implications for hospitals.

Methods

We utilized 100% national Medicare Part A fee-for-service (FFS) patient-level claims data for 2017–2018. We excluded DRG 469 TKAs since they are unlikely to be outpatient candidates, which left 257,107 primary TKAs in 2017 and 264,393 in 2018. We examined the time trend in monthly case volume and 30-day retreatment rate (defined as percent of patients having a second TKA within 30 days of the first. We calculated the loss in revenue for a hospital by multiplying the decrease in payment rate between inpatient and outpatient by the outpatient and total 2018 TKA volume.


S. P. Ryan J. F. Plate C. Black C. Howell W. Jiranek M. P. Bolognesi T. M. Seyler

Introduction

Bundled reimbursement models for total knee arthroplasty (TKA) by the Center for Medicare and Medicaid Services (CMS) have resulted in an effort to decrease the cost of care. However, these models may incentivize bias in patient selection to avoid excess cost of care. We sought to determine the impact of the Comprehensive Care for Joint Replacement (CJR) model at a single center.

Methods

This is a retrospective review of primary TKA patients from July 2015-December 2017. Patients were stratified by whether or not their surgery was performed before or after implementation of the CJR bundle. Patient demographic data including age, sex, and BMI were collected in addition to Elixhauser comorbidities and ASA score. In-hospital outcomes were then examined including surgery duration, length of stay, discharge disposition, and direct cost of care.


K. A. Gustke

Introduction

The purpose of bundled payment programs is to reduce cost via risk sharing, while still maintaining quality. If savings are achieved under a historic target price, the orthopedic surgeon will receive a monetary bonus. If costs are higher, a portion is deducted from payment to the orthopedic surgeon. The purpose of this study was to evaluate our experience with the Bundled Payments for Care Improvement Program (BPCI) when run by an orthopedic surgeon group to determine patient safety and who benefited the most financially.

Methods

This program ran from January 2015 through September 2018. 3,186 Medicare total hip and knee replacements, elective (DRG 470) and for fracture (DRG 469), performed by our group were included. 90 day hospital and all postoperative expenditures were reconciled against our historic cost. All patients were medically optimized with discharge plans established preoperatively. We developed preferred skilled nursing facilities and home health care agencies with synergistic medical providers so that discharges were recommended as soon as appropriate. We hired two full-time case managers to have direct contact with patients pre-and post-operatively. Waiver assistance such as house and pet sitters were used if necessary at our expense. 35% of savings went to the convener, who acted as a liaison between our group and CMS. Expenditures for the 90-day period for all patients were calculated to determine where savings occurred and which entity benefitted financially.


J. A. Browne N. D. Quinlan D. Q. Chen B. C. Werner

Introduction

As total knee arthroplasty incidence in the United States continues to increase, health care entities are looking to reform policy to decrease costs while improving efficiency and quality of care. The allocation of hospital and surgeon charges and payments is an important aspect of health care economics, but the trends and relationship between surgeon and hospital charges and payments for knee arthroplasty have not been well examined. The goal of this study is to report trends and variation in hospital charges and payments compared to surgeon charges and payments for total knee arthroplasty in a Medicare population.

Methods

The 5% Medicare sample was used to capture hospital and surgeon charges and payments for total knee arthroplasty from 2005–2014. Two important values were calculated: (1) the charge multiplier (CM) which is the ratio of hospital to surgeon charges, and (2) the payment multiplier (PM), which is the ratio of hospital to surgeon payments. The year to year variation and regional trends in patient demographics, Charlson Comorbidity Index (CCI), length of stay (LOS), CM and PM were evaluated for all patients. Statistical significance of trends was evaluated using student's t-tests. Correlations between the financial multipliers and LOS were evaluated using a Pearson correlation coefficient (r).


K. L. Young-Shand P. C. Roy M. J. Dunbar S. S. R. Abidi J. L. Astephen-Wilson

Introduction

Identifying knee osteoarthritis patient phenotypes is relevant to assessing treatment efficacy. Biomechanical variability has not been applied to phenotyping, yet features may be related to outcomes of total knee arthroplasty (TKA), an inherently mechanical surgery. This study aimed to i) identify biomechanical phenotypes among TKA candidates based on demographic and gait mechanic similarities, and ii) compare objective gait improvements between phenotypes post-TKA.

Methods

TKA patients underwent 3D gait analysis one-week pre (n=134) and one-year post-TKA (n=105). Principal component analysis was applied to frontal and sagittal knee angle and moment gait waveforms, extracting major patterns of variability. Demographics (age, sex, BMI), gait speed, and frontal and sagittal pre-TKA angle and moment principal component (PC) scores previously found to differentiate sex, osteoarthritis (OA) severity, and symptoms of TKA recipients were standardized (mean=0, SD=1, [134×15]) to perform multidimensional scaling and machine learning based hierarchical clustering. Final clusters were validated by examining inter-cluster differences at baseline and gait changes (PostPCscore–PrePCscore) by k-way Chi-Squared, and ANOVA tests.


C. Klemt P. Arauz Y-M. Kwon

Introduction

Inability to reproduce 6-degrees of freedom (6DOF) kinematics, abnormal “paradoxical” anterior femoral translation and loss of normal medial pivot rotation are challenges associated with contemporary posterior cruciate retaining and posterior stabilized total knee arthroplasty (TKA). The removal of the anterior and/or both cruciate ligaments in CR/PS TKA, leading to significant kinematic alteration of the knee joint, has been suggested as one of the potential contributory factors in patients remaining dissatisfied after TKA. Bi-cruciate retaining (BCR) TKA designs allow preservation of both anterior and posterior cruciate ligaments with the potential to replicate normal knee joint kinematics. Physically demanding tasks such as sit-to-stand (STS), and deep lunging may be more sensitive tools for investigating preserved kinematic abnormalities following TKA. This study aims to compare in-vivo kinematics between the operated and the contralateral non-operated knee in patients with contemporary BCR TKA design.

Methods

Twenty-nine patients (14 male; 15 female, 65.7±7.7 years) unilaterally implanted with a contemporary BCR TKA design featuring an asymmetric femoral component and independently designed medial and lateral bearings were evaluated. Mean follow-up time after BCR TKA was 12.7±5.1 months. All patients received a computer tomography (CT) scan from the pelvis to the ankles for the creation of 3D surface models of both knees (BCR TKA and non-operated). Patients performed single leg deep lunges and sit-to-stand under a validated dual fluoroscopic imaging system (DFIS) surveillance. Each patient's 2D dynamic fluoroscopic images, corresponding 3D surface bone models (for contralateral non-operated knee) and computer aided design (CAD) implant models (for the BCR TKA implanted knee) were imported into a virtual DFIS environment in MATLAB. An optimization procedure was utilized to perform matching between the 3D surface bone models and the 2D fluoroscopic image outlines. In-vivo 6DOF kinematics of the BCR TKA knees and contralateral non-operated side were quantified and analyzed.


J. J. Jacobs C. B. Knowlton H. J. Lundberg M. A. Wimmer

Introduction

Studies of retrieved total knee replacement (TKR) components demonstrate that in vivo wear on the articular surface of polyethylene liners exhibits a much higher variability than their in vitro counterparts tested on simulators.1 Only one study has attempted to validate a patient-specific model of wear with a clinically retrieved component.2 The purpose of this study is to investigate the relationship between observed TKR contact conditions during gait and measured volume loss on retrieved tibial components.

Methods

Eleven retrieved ultra-high molecular weight polyethylene (UHMWPE) cruciate-retaining tibial liner components from ten separate patients (implantation time = 8.6±5.6 years) had matching gait trials of normal level walking for each knee. Volume loss on retrieved components was calculated using a coordinate measuring machine and autonomous reconstruction.3 Motion analysis of normal level walking gait had been conducted between 1986 and 2005 for various previous studies and stored in a consented Human Mechanics Repository, ranging from pre-operative to long-term post-operative testing. Contact location between the femoral component and the tibial component on the medial and lateral plateaus were calculated throughout stance.4 A previously validated and fine-tuned parametric numerical model was used to calculate TKR contact forces for each gait trial.5 Vertical contact forces and contact paths on the medial and lateral plateaus were input as normal force and sliding distance to a simplified Archard equation for wear with material wear constant = 2.42 × 10−7 mm3/Nm2,6 to compute average wear per gait cycle. Wear rates were calculated using linear regression, and Pearson correlation examined correlations between modeled and measured wear.


P. C. Noble

Introduction

The association between CoCr joint replacements and adverse tissue reactions has led to increased interest in alternative materials that are both biocompatible and wear-resistant. One approach is to manufacture components from titanium alloys with a hardened articulating surface to increase resistance to scratching and surface damage caused by third-body particles. In this study we investigate methods for characterizing the performance of retrieved TiAlV components with nitrogen-hardened bearing surfaces.

Methods

Surface-hardened titanium knee implants (TiNidium) were retrieved from 18 patients (7.7 ±6.8 years) at revision surgery. After processing, the bearing surface of each component was characterized by stereomicroscopy, SEM, optical profilometry, and incremental nano-indentation hardness testing. A case-matched set of 18 CoCr components (6.7 ±5.6 years) were characterized for comparison.


S. Matsuda K. Nishitani

Introduction

The relationship between sagittal component alignment on clinical outcomes has not fully evaluated after TKA. This study evaluated the effect of sagittal alignment of the components on patient function and satisfaction as well as kinematics and kinetics.

Methods

This study included 148 primary TKAs with cruciate-substituting prosthesis for primary OA. With post-operative lateral radiograph, femoral component flexion angle (γ) and tibial component posterior slope angle (90-σ) was measured. The patients was classified into multiple groups by every three degrees. Patient satisfaction in 2011KSS among groups were analyzed using one-way analysis of variance. By representing the component position which showed poor clinical outcomes, computer simulation analysis was performed, in which kinematics and kinetics in squatting activity were investigated.


W. G. Hamilton N. L. Parks J. M. Gargiulo

Introduction

Pharmacogenetics evaluates a patient's DNA to determine if a particular drug is expected to have a normal clinical effect, heightened effect, or no effect at all on a patient. It may also predict which patients are most likely to experience side effects from the medications. The purpose of this study was to use pharmacogenetic testing to determine how frequently total knee arthroplasty (TKA) patients have genetic variants to standard postoperative pain medications. We further sought to determine if changing the multimodal program based on these results would improve pain control and reduce side effects.

Methods

In this prospective, randomized study, buccal cheek swab samples were collected from 31 primary TKA patients. Pharmacogenetics testing was performed on the samples to examine genetic variants in genes OPRM1, CYP1A2, CYP2B6, CYP2C19, CYP3A4, CYP2C9, and CYP2D6. These genes affect the pharmacodynamics and pharmacokinetics of NSAIDs and opioids. We examined the frequency of a genetic variant to one of the multimodal medications we prescribe including celecoxib, hydrocodone, and tramadol. Subjects included 9 men and 22 women. Patients were randomized to one of two groups: the control group received the standard postoperative pain regimen; the study group received a customized regimen based on the pharmacogenetic results. For the first 10 postoperative days patients recorded pain scores, amount of pain medication taken, and any side effects experienced.


E. A. Korte A. L. Malkani J. Gaskins B. Hartley L. J. Langman P. Jannetto G. McMillin C. Maluf S. A. Jortani

Introduction

Insufficient pain control following lower extremity surgery can increase length of stay, readmission rates, and impair postoperative outcome. It has been shown that CYP2D6 genotypes predict function of the enzyme responsible for conversion of hydrocodone to hydromorphone (active metabolite) and plasma concentration of hydromorphone best predicted analgesic response. Purpose of this study was to evaluate relationship of CYP2D6 genotypes, drug-drug interactions, and plasma drug concentrations in patients undergoing lower extremity surgery.

Methods

A prospective cohort of 271 orthopedic patients undergoing lower extremity surgery including TKA, THA and trauma were queried. Patients treated with hydrocodone were enrolled and tested for plasma concentrations of hydrocodone and hydromorphone. CYP2D6 genotyping was performed. Medications co-administered with hydrocodone during perioperative and postoperative periods were queried.


R. N. Maniar D. Jain A. R. Maniar N. Bhatnagar A. J. Gajjar

Introduction

Low serum Vitamin D (VitD) levels are often found in patients being investigated for Total Knee Arthroplasty (TKA). VitD deficiency is associated with poor pre/post-operative functional scores and higher rate of complications. Studies report VitD as an important modifiable risk factor to improve outcomes post TKA.

Aim

Aim of our study was 1) To examine the trajectory of VitD in TKA patients over 2 weeks, which included VitD sufficient and deficient patients who were supplemented orally or intramuscularly (IM) for comparision. 2) To compare early (2weeks) functional recovery in VitD sufficient and deficient patients.


K. D. Harper B. S. Lambert T. C. Sullivan S. J. Incavo

Introduction

Vancomycin is a prophylactic antibiotic used to protect against methicillin resistant staph aureus. Recent literature has suggested that using intraosseus (IO) infusions are capable of providing improved local tissue concentrations compared to intravenous (IV) access. The purpose of this study is to evaluate clinical outcomes of patients who received pre-operative IO vancomycin for total knee arthroplasty (TKA).

Methods

Patients who received IO vancomycin (500mg vancomycin in 200ml NS) as standard of care from September 1, 2018 to March 1, 2019 were retrospectively evaluated. This data was compared to primary and revision TKAs performed immediately prior to the initiation of IO administration. Evaluation included pre and post-op creatinine values, tourniquet time (TT), and knee-related 30 and 90-day complications. Data for primary and revision TKA cases were analyzed independently.


S. W. Young H. D. Clarke G. A. Moore M. Zhang N. E. Probst M. J. Spangehl

Introduction

Intraosseous administration of low dose vancomycin has been proven to produce 6 to 20 times higher tissue concentrations compared to intravenous administration in both primary and revision knee replacement. However, these superior levels are achieved when the antibiotic given intraosseously is administered distal to a tourniquet that is inflated for the majority of the case. With increasing interest in limited, or no, tourniquet use during TKA we sought to study the tissue concentrations achieved with limited tourniquet use and intraosseously administered vancomycin compared to weight-based, time optimized intravenous administration.

Methods

Twenty-four patients undergoing primary TKA were randomized to two groups. The Intravenous (IV) Group received weight based (15mg/kg) vancomycin timed to finish before incision. The Intraosseous (IO) Group received 500 mg of vancomycin injected as a bolus through a needle into the proximal tibia distal to an inflated tourniquet prior to skin incision. In the IO group, the tourniquet was deflated 10 minutes following the injection and re-inflated only for cementation. In the IV group, the tourniquet was only inflated for cementation. During the procedure, fat and bone samples were taken at regular intervals. Tissue antibiotic concentrations were measured using a validated technique involving high performance liquid chromatography.


M. Borse Glassberg P. F. Lachiewicz

Introduction

There is insufficient data on the trends of anticoagulation after total knee arthroplasty (TKA) in the USA, and the efficacy and safety of rivaroxaban, beyond randomized clinical trials and small cohort studies.

Patients and Methods

Using the Truven Health MarketScan database, we retrospectively evaluated new anticoagulation prescriptions after elective TKA from 2010 to 2015. The frequency of deep vein thrombosis (DVT), pulmonary embolism (PE), and adverse events, within 90 days, were then evaluated in 24,856 new users of warfarin and 21,398 new users of rivaroxaban in commercially insured patients (COM), and 15,483 new users of warfarin and 8,997 new users of rivaroxaban in Medicare supplement patients (MED). Data was analyzed by odds ratios using logistic regression models with stabilized inverse probability treatment weighting.


J. S. Broberg M. G. Teeter B. Lanting E. M. Vasarhelyi J. L. Howard X. Yuan D. D. R. Naudie

Introduction

Surgeons performing a total knee replacement (TKR) have two techniques to assist them achieve proper bone resections and ligament tension – gap balancing (GB) and measured resection (MR). GB relies on balancing ligaments prior to bony resections, whereas bony resections are made based on anatomical landmarks in MR. Many studies have been done to compare the implant migration and kinematics between the two techniques, but the results have been varied. However, these studies have not been done on modern anatomically designed prostheses using radiostereometric analysis (RSA). Anatomical designs attempt to mimic the normal knee joint structure to return more natural kinematics to the joint, with emphasis on eliminating both paradoxical anterior motion and reduced posterior femoral rollback. Given the major design differences between anatomical and non-anatomical prostheses, it is important to investigate whether one surgical technique may have advantages another. We hypothesize that there would be no difference between GB and MR techniques in implant migration, but that GB might provide better knee kinematics.

Methods

Patients were recruited to receive an anatomically designed prosthesis and randomized to groups where the GB or MR technique is used. For all patients in the study, RSA images were acquired at a 2 week baseline, as well as at 6 weeks, 3 months, and 6 months post-operatively. These images were used to collect the maximum total point motion (MTPM) of the tibial and femoral implant components relative to the bone using a model-based RSA software. A series of RSA images were also acquired at 3-months post-operatively at different knee flexion angles, ranging in 20° increments from 0° to 100°. Model-based RSA software was used to obtain the 3D positions and orientations of the femoral and tibial components, which were used to obtain the anterior-posterior (AP) contact locations for each condyle.


A. B. Mullaji T. Panjwani

Aims

The aims of this prospective study were to determine the effect of osteophyte excision on deformity correction and soft-tissue gap balance in varus knees undergoing computer-assisted total knee arthroplasty (TKA).

Patients and Methods

Four-hundred twenty-five consecutive, cemented, cruciate-substituting TKAs were analysed. Pre-operative varus was calculated on long leg weight-bearing HKA film. Limb deformity in coronal (varus) and sagittal (flexion) planes, medial and lateral gap distances in maximum knee extension and 90° knee flexion and maximum knee flexion were recorded before and after excision of medial femoral and tibial osteophytes using computer navigation. Data was extracted and analysed to assess the effect of removal of osteophytes on the correction of deformity and soft tissue balance.


P. K. Sculco M. LaGreca J. L. Adonna K. M. Carroll S. B. Haas D. J. Mayman

Introduction

One of the more common complaints from patients in their post-operative total knee arthroplasty (TKA) is the perceived feeling of the operative leg feeling longer than the non-operative leg. Studies have shown that the leg length discrepancies may occur in up to 80% of patients following unilateral TKA patients. The purpose of this study was to determine the incidence of leg length discrepancy (LLD) after primary TKA as well as determine the correlation between deformity and incidence of LLD.

Methods

We retrospectively reviewed 1108 patients who underwent a primary unilateral TKA at a single institution. 97 patients were excluded for lack of imaging, prior total hip replacement or body mass index greater than 40 kg/m2. Hip to ankle biplanar radiographs were obtained pre-operative and 6 weeks postoperatively for all patients. Two independent observers measures leg length, femur length, tibia length, overall alignment and deformity present for all radiographs.


B. Kayani S. Konan S. Horriat F. S. Haddad

Introduction

The objective of this study was to assess the effect of PCL resection on flexion-extension gaps, mediolateral soft tissue laxity, fixed flexion deformity (FFD), and limb alignment during posterior-stabilised total knee arthroplasty (TKA).

Methods

This prospective study included 110 patients with symptomatic knee osteoarthritis undergoing primary robotic-arm assisted posterior-stabilised TKA. All operative procedures were performed by a single surgeon using a standard medial parapatellar approach. Optical motion capture technology with fixed femoral and tibial registration pins was used to assess gaps pre- and post-PCL resection in knee extension and 90 degrees knee flexion. This study included 54 males (49.1%) and 56 females (50.9%) with a mean age of 68 ± 6.2 years at time of surgery. Mean preoperative hip-knee-ankle deformity was 6.1 ± 4.4 degrees varus.


L. C. Warth E. R. Deckard R. M. Meneghini

Introduction

t is accepted dogma in total knee arthroplasty (TKA) that resecting the posterior cruciate ligament (PCL) increases the flexion space by approximately 4mm, which significantly affects intra-operative decisions and surgical techniques. Unfortunately, this doctrine is based on historical cadaveric studies of limited size. This study purpose was to more accurately determine the effect of PCL resection on the tibiofemoral flexion gap dimension in vivo in a large sample.

Methods

Tibiofemoral joint space measurements were made during 127 standardized TKAs by two arthroplasty surgeons. A medial parapatellar approach, computer navigation and provisional tibial and femoral bone cuts were performed in all cases with particular attention to preserving PCL integrity. Cases with an incompetent or damaged PCL were excluded. The tibiofemoral gap dimension was measured with a calibrated tension device at full extension, 45-degrees, and 90-degrees before and after complete PCL resection.


P. B. White J. Satalich A. S. Ranawat C. S. Ranawat

Background

The purpose of this study was to evaluate the clinical and radiographic outcomes of the rotating-platform, posterior-stabilized PFC Sigma at fifteen-year follow-up.

Methods

Between January 2000 and November 2001, two hundred consecutive patients underwent TKA with a rotating-platform, posterior stabilized total knee arthroplasty with cement. All patients have been followed prospectively and all patients with minimum 12 year follow up were included in this analysis. Forty-nine TKAs were available for our final analysis with a mean follow up of 16.0 years.


K. R. Berend D. A. Crawford J. B. Adams A. V. Lombardi

Introduction

Patients are often cautioned against a high level of activity following knee arthroplasty. The purpose of this study is to report on implant survivorship and outcomes of high activity patients compared to low activity patients after TKA.

Methods

We identified 1611 patients (2038 knees) who underwent TKA with 5-year minimum follow-up. Patients were divided in two groups: Low activity (LA) (UCLA ≤5) and high activity (HA) (UCLA ≥ 6). Pre-and postoperative ROM, Knee Society scores, complications and reoperations were evaluated.


M. P. Figgie J. L. Blevins E. C. Krell Y-F. Chiu J. D. Stimac T. J. Heyse M. P. Abdel

Introduction

Primary total knee arthroplasties (TKA) performed in younger patients raise concerns regarding the potential for accelerated polyethylene wear, aseptic loosening, and thus revision TKA at a younger age. The purpose of this study was to determine the long-term implant survivorship, functional outcomes, and pain relief of primary TKA performed in patients under 35 years of age.

Methods

A retrospective review of our institutional registry identified 185 TKAs performed in 119 patients under the age of 35 between 1985 and 2010. Medical records and radiographs were reviewed. Patients were contacted for two serial questionnaires in 2011–2012 and again in 2018. Implant survivorship was calculated using Kaplan-Meier survivorship curves and Cox proportional hazard model. The median age was 26.1 (21.5–30.1) years, with a BMI of 23.5 (20.4–26.6) kg/m2. Median follow-up was 13.9 (8.5–19.8) years.


D. J. Mayman S. Sutphen H. Bawa K. M. Carroll S. A. Jerabek S. B. Haas

Introduction

Up to 15 % of patients report anterior knee pain (AKP) after a total knee arthroplasty (TKA). The correlation of radiographic patellar measurements and post-operative AKP remains controversial. The purpose of this study was to determine whether any radiographic measurements can predict anterior knee pain after TKA.

Methods

We performed a retrospective analysis of data on 343 patients who underwent a primary unilateral TKA between 2009–2012 at a single institution. Post-operative radiographs were evaluated with standing anteroposterior, lateral, and merchant views. Radiographic assessment was performed to assess posterior offset, Insall Salvati ratio, Blackburne, PP angle, Patella thickness, Congruence angle, Patella tilt, and patella displacement. Clinical function was assessed by the Kujala anterior knee pain scale at a minimum of 5 years. Patients were asked if they currently had anterior knee pain post-operatively by responding “yes” or “no.” There were 264 females and 79 males; the mean age at surgery was 64.2 ± 9.7 (range, 42–92 years) years; the mean BMI 31±5.8 kg/m2 (range, 18.8–49 kg/m2).


J. L. Blevins V. Rao Y-F. Chiu G. H. Westrich

Background

Obesity has been shown to be an independent risk factor for aseptic loosening of the tibia and smaller implant size has been correlated with increased risk of failure of tibial components in obese patients [1,2]. Many surgeons have noted that obese patients, especially females, not uncommonly will have small implant sizes. As such, we hypothesized that obesity was not directly correlated with total knee arthroplasty (TKA) implant sizes. The purpose of this study was to determine if increasing body mass index (BMI), height, and/or weight is associated with implant size in primary TKA.

Methods

The institutional registry of a single academic center was reviewed to identify all primary TKAs performed between 2005 and 2016. Those without minimum 2-year follow-up or with incomplete implant data were excluded. The different manufacturer's implant designs were categorized based on anteroposterior and mediolateral dimensions of the femoral and tibial component sizes and cross sectional area was determined. BMI was categorized by the World Health Organization (WHO) obesity scale (Class I: BMI 30 to <35, Class II: BMI 35 to <40, Class III: BMI 40 kg/m2 or greater). Patient demographics including sex, height, weight, and BMI were analyzed to evaluate correlations with implant size using Pearson correlation coefficients.


J. A. Padilla J. A. Gabor A. Orio J. D. Slover R. Schwarzkopf W. B. Macaulay

Introduction

Patients who undergo total joint arthroplasty (TJA) are at a high risk for the development of thromboembolic complications. The rate at which venous thromboembolism occurs following TJA has been reported to be between 1.3–9.4%. As a result, the utilization of prophylactic therapies is considered standard of care in this patient population. The primary purpose of the current study was to 1) evaluate patient satisfaction with the use of intermittent compression devices 2) evaluate the risk of self-reported falls secondary to the use of these devices following TJA.

Methods

This is a single institution, prospective study on patients who underwent TJA at an urban, academic orthopedic specialty hospital. Patients were surveyed using an electronic patient rehabilitation application regarding their use and satisfaction with their home intermittent compression devices with a battery and power cord attachment that the patient must wear while using the devices. They were also asked if any falls or near-falls they may have experienced. Surveys were administered on postoperative Day 14, and patients were given 10 days to submit their responses. Using our institutions data warehouse, patient demographics were also collected (Table 1).


L. Dumenci R. A. Perera F. J. Keefe D. C. Ang J. D. Slover M. P. Jensen D. L. Riddle

Introduction

Knee arthroplasty (KA) is a highly effective surgical procedure. However, research suggests that a considerable number of patients continue to experience substantial pain and functional loss following surgical recovery. We aimed to estimate pain and function outcome trajectories for persons undergoing KA depicting the outcome, the relationship between the pain and function trajectory types, and pre-surgery predictors of trajectory type (i.e., good versus poor).

Methods

Participants included 384 patients who took part in the Knee Arthroplasty Skills Training (KASTPain) clinical trial. Pain and function was assessed at 2-week pre- and 2-, 6-, and 12-month post-surgery using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain and Function Scales. Piecewise latent class growth models were used to estimate pain and function trajectories. Dumenci's latent kappa was used to estimate the chance-corrected agreement between pain and function trajectory types. Pre-surgery variables were used to predict trajectory types.


W. M. Mihalko A. Kerkhof J. L. Guyton J. R. Crockarell J. W. Harkess M. C. Ford

Introduction

Even as the outcomes of primary total knee arthroplasty (TKA) continue to improve, there remain increasing concerns about pain control after surgery and prolonged narcotic use. Cryoneurolysis has been demonstrated to reduce osteoarthritis knee pain for up to 90 days. We hypothesized that postoperative narcotic use could be reduced following preoperative cryoneurolysis of the superficial genicular nerves.

Methods

Primary TKA patients were randomized into either a control or cryoneurolysis treatment group. Both followed the same preoperative, intraoperative, and postoperative pain management protocol, except the treatment group had cryoneurolysis of their superficial genicular nerves 3–7 days prior to surgery. All patients were prescribed 40 narcotic pills at discharge and pills were counted at 72 hours and at 2,6, and 12 weeks postoperatively. The primary endpoint was daily morphine equivalent (DME) based on pill count and secondary endpoints were changes in pain and Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS, Jr.) scores.


M. Greenky M. McGrath E. A. Levicoff R. P. Good J. Nguyen A. M. Makhdom J. H. Lonner

Introduction

Controlling post-operative pain and reducing opioid requirements after total knee arthroplasty (TKA) remains a challenge, particularly in an era stressing rapid recovery protocols and early discharge. A single shot adductor canal block (ACB) has been shown to be effective in decreasing post-operative pain. This requires a specialty-trained Anesthesiologist skilled in ultrasound techniques, which imposes cost, time and skill barriers. Cadaveric studies and magnetic resonance imaging data have shown that access to the adductor canal is possible from within the joint, and thus the potential for intraoperative, intra-articular, surgeon administered ACB through a standard surgical approach is a feasible alternative to ultrasound guided ACB at the time of TKA. The purpose of the present study is to compare the efficacy of surgeon administered intraoperative ACB to anesthesiologist administered ACB.

Methods

Patients' undergoing primary TKA were prospectively randomized to receive either an Anesthesiologist administered (Group 1) or Surgeon administered (Group 2) ACB using 15 ml of Ropivacaine 0.5%, both in conjunction with spinal anesthesia. Perioperative multimodal anesthesia was standardized for the two groups. Primary outcomes were pain visual analogue scale (VAS), range of motion, and opioid consumption. Secondary outcomes were patient satisfaction scores and length of stay (LOS).


T. P. Vail R. F. Shah S. A. Bini

Background

Implant loosening is a common cause of a poor outcome and pain after total knee arthroplasty (TKA). Despite the increase in use of expensive techniques like arthrography, the detection of prosthetic loosening is often unclear pre-operatively, leading to diagnostic uncertainty and extensive workup. The objective of this study was to evaluate the ability of a machine learning (ML) algorithm to diagnose prosthetic loosening from pre-operative radiographs, and to observe what model inputs improve the performance of the model.

Methods

754 patients underwent a first-time revision of a total joint at our institution from 2012–2018. Pre-operative X-Rays (XR) were collected for each patient. AP and lateral X-Rays, in addition to demographic and comorbidity information, were collected for each patient. Each patient was determined to have either loose or fixed prosthetics based on a manual abstraction of the written findings in their operative report, which is considered the gold standard of diagnosing prosthetic loosening. We trained a series of deep convolution neural network (CNN) models to predict if a prosthesis was found to be loose in the operating room from the pre-operative XR. Each XR was pre-processed to segment the bone, implant, and bone-implant interface. A series of CNN models were built using existing, proven CNN architectures and weights optimized to our dataset. We then integrated our best performing model with historical patient data to create a final model and determine the incremental accuracy provided by additional layers of clinical information fed into the model. The models were evaluated by its accuracy, sensitivity and specificity.


M. Hevesi C. C. Wyles J. J. Yao H. Maradit-Kremers E. B. Habermann K. A. Bews J. E. Ransom D. G. Lewallen D. J. Berry

Introduction

Revision total knee arthroplasty (revision TKA) occurs for a wide variety of indications and along with revision total hip arthroplasty is billed for using Diagnosis-Related Groups (DRGs) 466, 467, and 468 in the United States. However, DRGs do not account for revision etiology, a potentially substantial driver of cost. This study investigates revision TKA costs and 30-day complications by indication, employing both local granular as well as national standardized databases.

Methods

Hospitalization costs and complication rates for 1,422 aseptic revision TKAs performed at a high-volume center between 2009 and 2015 were retrospectively reviewed. Additionally, charges for 28,173 revision TKAs in the National Inpatient Sample (NIS) were converted to costs using the Healthcare Cost and Utilization Project cost-to-charge ratios. 30-day complication rates for 3,450 revision TKAs were obtained using the American College of Surgeons National Surgical Quality Improvement Project (ACS-NSQIP). Costs and complications were compared between revision TKAs performed for the indication of fracture, wear/loosening, and instability with use of simultaneous and pairwise comparisons and a multivariable model accounting for American Society of Anesthesiologists (ASA) score, age, and sex.


K. A. Fehring C. C. Wyles R. T. Trousdale

Introduction

In the setting of periprosthetic joint infection, the complete removal of implants and cement can be challenging with well-fixed, cemented implants about the knee. This can get especially complex in the setting of long cemented femoral stems. Osteotomies are well described in the proximal femur and tibia for removal of implants and cement. There is little information available on distal femoral osteotomies to facilitate knee implant and retained cement removal.

Methods

We describe a novel anterolateral oblique distal femoral osteotomy for the removal of well-fixed, cemented components during resection knee arthroplasty that preserves vascularity to the osteotomized segment. Cadaveric anatomic vascular injection studies were performed to document vascularity of the osteotomized segment. Clinical examples, and results will be presented.