There are several methods for evaluating stability of the joint during total knee replacement (TKR). Activities of daily living demand mechanical loading to the knee joint, not only in full extension, but also in mid-flexion. The purpose of this study was to compare the varus-valgus stability throughout flexion in knees treated with either cruciate-retaining or posterior-stabilised TKR, using an intra-operative navigation technique. A total of 34 knees underwent TKR with computer navigation, during which the investigator applied a maximum varus-valgus stress to the knee while steadily moving the leg from full extension to flexion both before and after prosthetic implantation. The femorotibial angle was measured simultaneously by the navigation system at every 10° throughout the range of movement. It was found that posterior-stabilised knees had more varus-valgus laxity than cruciate-retaining knees at all angles examined, and the differences were statistically significant at 10° (p = 0.0093), 20° (p = 0.0098) and 30° of flexion (p = 0.0252). Cite this article: Bone Joint J 2013;95-B:493–7

Aims. Surgeons commonly resect additional distal femur during primary total knee arthroplasty (TKA) to correct a flexion contracture, which leads to femoral joint line elevation. There is a paucity of data describing the effect of joint line elevation on mid-flexion stability and knee kinematics. Thus, the goal of this study was to quantify the effect of joint line elevation on mid-flexion laxity. Methods. Six computational knee models with cadaver-specific capsular and collateral ligament properties were implanted with a posterior-stabilized (PS) TKA. A 10° flexion contracture was created in each model to simulate a capsular contracture. Distal femoral resections of + 2 mm and + 4 mm were then simulated for each knee. The knee models were then extended under a standard moment. Subsequently, varus and valgus moments of 10 Nm were applied as the knee was flexed from 0° to 90° at baseline and repeated after each of the two distal resections. Coronal laxity (the sum of varus and valgus angulation with respective maximum moments) was measured throughout flexion. Results. With + 2 mm resection at 30° and 45° of flexion, mean coronal laxity increased by a mean of 3.1° (SD 0.18°) (p < 0.001) and 2.7° (SD 0.30°) (p < 0.001), respectively. With + 4 mm resection at 30° and 45° of flexion, mean coronal laxity increased by 6.5° (SD 0.56°) (p < 0.001) and 5.5° (SD 0.72°) (p < 0.001), respectively. Maximum increased coronal laxity for a + 4 mm resection occurred at a mean 15.7° (11° to 33°) of flexion with a mean increase of 7.8° (SD 0.2°) from baseline. Conclusion. With joint line elevation in primary PS TKA, coronal laxity peaks early (about 16°) with a maximum laxity of 8°. Surgeons should restore the joint line if possible; however, if joint line elevation is necessary, we recommend assessment of coronal laxity at 15° to 30° of knee flexion to assess for mid-flexion instability. Further in vivo studies are warranted to understand if this mid-flexion coronal laxity has negative clinical implications. Cite this article: Bone Joint J 2021;103-B(6 Supple A):87–93

The term mid-flexion instability has entered the orthopaedic literature as a concept, but has not been confirmed as a distinct clinical entity. The term is used freely, sometimes as a synonym for flexion instability. However, the terms need to be clearly separated. A cadaver study published in 1990 associated joint line elevation with decreased stability at many angles of flexion, but that model was not typical of clinical scenarios. The literature is considered and it is proposed that the more common entity of an uncorrected flexion contracture after a measured resection arthroplasty technique is more likely to produce clinical findings that suggest instability mid-flexion. It is proposed that the clinical scenario encountered is generalised instability, with the appearance of stability in full extension from tight posterior structures. This paper seeks to clarify whether mid-flexion instability exists as an entity distinct from other commonly recognised forms of instability. Cite this article: Bone Joint J 2016;98-B(1 Suppl A):84–8

Background. Total knee arthroplasty (TKA) surgical techniques attempt to achieve equal flexion and extension gaps to produce a well-balanced knee, but unexplainable unhappy patients persist. Mid-flexion instability is one proposed cause of unhappy patients. There are multiple techniques to achieve equal flexion and extension gaps, but their effects in mid-flexion are largely unknown. Purpose of study. The purpose of the study is to determine the effects that changing femur implant size and/or adjusting the femur and tibia proximal -distal and femur anterior-posterior implant positions have on cruciate retaining (CR) TKA mid-flexion ligament balance when equal flexion and extension gaps are maintained. Methods. A computational analysis was performed simulating knee flexion of two CR TKA designs (JOURNEY II CR and LEGION HFCR; Smith & Nephew) using previously validated software (LifeMOD/KneeSim; LifeModeler). Deviations from the ideal implant position were simulated by adjusting tibiofemoral proximal-distal position and femur anterior-posterior position and size (Table 1). Positioning the femur more proximal was accompanied by equal anterior femur and proximal tibia shifts to maintain equal flexion and extension gaps. The forces in ligaments connecting the femur and tibia, which included superficial and posterior MCL, LCL, popliteal-fibular ligament complex, iliotibial band, and anterior-lateral and posterior-medial PCL, were collected. Total tibiofemoral ligament load and PCL load for 15–75° knee flexion were analyzed versus proximal-distal implant position, implant size, implant design, and knee flexion using a MANOVA in Minitab 16 (Minitab). Results. Total tibiofemoral ligament load was significantly reduced by a more proximal implant position (p<.001) (Figure 1) but was not affected by implant size (p>0.6). PCL load was not affected by implant proximal-distal position or size (p>0.9) (Figure 2). Therefore, the PCL did not contribute to changes in mid-flexion balance caused by proximal-distal implant position. Implant design and knee flexion significantly influenced total tibiofemoral ligament and PCL loads (p<.05), but the interactions with implant proximal-distal position and size were not significant (p>0.7) indicating that the effects of implant proximal-distal position applies across the studied implant designs and 15°–75° knee flexion range. Conclusions. Our results suggest that a CR TKA can be well balanced at 0° and 90° knee flexion and be too tight or loose in mid-flexion. Since placement of implant was the variable studied, when the knee is too tight in mid-flexion, our recommendation to loosen the knee is to resect more distal and posterior femur, downsizing if necessary, and increase the tibial insert thickness. The opposite could be done to guard against the knee being too loose in mid-flexion. Finally, it is recommended to gauge balance in more than simply 0° and 90° to determine overall knee balance

Introduction. Surgeons commonly resect additional distal femur during primary total knee arthroplasty (TKA) to correct a flexion contracture. However, the effect of joint line proximalization on TKA kinematics is unclear. Thus, our goal was to quantify the effect of additional distal femoral resection on knee extension and mid-flexion laxity. Methods. Six computational knee models with TKA-specific capsular and collateral ligament properties were implanted with a contemporary posterior-stabilized TKA. A 10° flexion contracture was modeled to simulate a capsular contracture. Distal femoral resections of +2 mm and +4 mm were simulated for each model. The knees were then extended under standardized torque to quantify additional knee extension achieved. Subsequently, varus and valgus torques of ±10 Nm were applied as the knee was flexed from 0° to 90° at the baseline, +2 mm, and +4 mm distal resections. Coronal laxity, defined as the sum of varus and valgus angulation with respective torques, was measured at mid-flexion. Results. With +2 mm and +4 mm of distal femoral resection, the knee extended an additional 4°±0.5° and 8°±0.75°, respectively. At 30° and 45°of flexion, baseline laxity averaged 4.8° and 5.0°, respectively. At +2 mm resection, mean coronal laxity increased by 3.1° and 2.7° at 30° and 45°of flexion, respectively. At +4 mm resection, mean coronal laxity increased by 6.5° and 5.5° at 30° and 45° of flexion, respectively. Maximal increased coronal laxity for a +4 mm resection occurred at a mean 16° (range, 11–27°) of flexion with a mean increased laxity of 7.8° from baseline. Conclusion. While additional distal femoral resection in primary TKA increases knee extension, the consequent joint line elevation induces up to 8° of coronal laxity in mid-flexion in this computational model. As such, posterior capsular release prior to resecting additional distal femur to correct a flexion contracture should be considered

Introduction. Mid-flexion stability after total knee arthroplasty (TKA) is dependent, in large part, on implant design. Design variables include retention or sacrifice of the posterior cruciate ligament, conformity of the polyethylene tibial surface, and radius of curvature of the femoral component. In this study, we attempted to isolate the impact of femoral component design by comparing a single-radius design (SR) to a J-Curve design (JC). We selected cruciate-retaining implants to eliminate the effect of a cam-and-post mechanism. Mid-flexion performance these two designs were compared using the Lower-Quarter Y-Balance Test (YBT-LQ), as well as patient reported outcomes and measures of physical performance. The YBT-LQ is a simple functional test of unilateral lower extremity strength and balance. Reach of the contralateral limb is measured in three different directions (Figures 1–3). Our hypothesis was that the SR design would provide superior mid-flexion stability, and therefore, a greater reach distance in the YBT-LQ when compared to the JC group. Methods. Patients undergoing primary, unilateral TKA were prospectively enrolled and block randomized to receive either the SR (n=30) or JC (n=30) implant. All surgeries were performed by one surgeon using a gap-balancing technique with a cruciate-retaining implant design. Patients completed outcome measures (KOOS, KSS, UCLA Activity), performed the YBT-LQ, and completed physical performance measures (walking speed, timed up-and-go, sit-to-stand) before surgery and 1 year postoperatively. A series of 2×2 repeated measures ANOVAS (Implant group x Time) were completed. Results. One year post-operatively, 40 patients (20 SR, 20 JC) were available for analysis. The groups were closely matched for age, gender, BMI, and ASA score. No significant differences existed between implant groups for the YBT-LQ or any other variable of interest. Significant improvements in both implant groups were observed for all variables of interest when comparing pre-operative to one year post-operative. Conclusions. Both groups improved significantly across time in all measures, but no differences were seen between SR and JC designs. Based on reach distances achieved, it is probable that many patients were not able to achieve mid-flexion during the YBT-LQ test. With regards to mid-flexion function after TKA, the significant limitations in strength and balance in this cohort of patients likely outweigh any subtle differences in implant design. For any figures or tables, please contact authors directly (see Info & Metrics tab above).

Introduction. The aim of this study was to quantify mid-flexion laxity in a total knee arthroplasty with an elevated joint line, as compared to a native knee and a TKA with joint line maintained. Our hypothesis was joint line elevation of 4mm would increase coronal plane laxity throughout mid-flexion in a pattern distinct from the preoperative knee or in a TKA with native joint line. Methods. Six fresh-frozen cadaver legs from hip-to-toe underwent TKA with a posterior stabilised implant (APEX PS, OMNIlife Science, Inc.) using a computer navigation system equipped with a robotic cutting-guide, in this controlled laboratory cadaveric study. After the initial tibial and femoral resections were performed, the flexion and extension gaps were balanced using navigation, and a 4mm recut was made in the distal femur. The remaining femoral cuts were made, the femoral component was downsized by resecting an additional 4mm of bone off the posterior condyles, and the polyethylene was increased by 4mm to create a situation of a well-balanced knee with an elevated joint line. The navigation system was used to measure overall coronal plane laxity by measuring the mechanical alignment angle at maximum extension, 30, 45, 60 and 90(of flexion, when applying a standardised varus/valgus load of 9.8Nm across the knee using a 4kg spring-load located at 25cm distal to the knee joint line. Laxity was also measured in the native knee, as well as the native knee after a standard approach during TKA which included a medial release. Coronal plane laxity was defined as the absolute difference (in degrees) between the mean mechanical alignment angle obtained from applying a standardised varus and valgus stress at 0, 30, 45, 60 and 90(. Results. In full extension, 30(, 45(, 60(, and 90(of flexion, the native knee showed coronal plane laxity of 2.4, 6.5, 7.0, 7.8, and 9.5(, respectively. The above soft tissue releases produced increased laxity in extension and 30(of flexion. After TKA, the mean coronal plane motion was decreased at all flexion angles and remained consistent throughout arc of motion. With 4mm of joint line elevation, coronal-plane laxity increased by a mean of 1.4° at 30° of flexion (p=.0.0103), 1.5° at 45° of flexion (p=.0.0001), and 1.3° at 60° of flexion (p=0.0018) compared to the TKA with native joint line. Conversely, there was no difference in laxity at 0° and 90° between the initial TKA and after 4mm joint line elevation. Conclusions. The computer navigated, well balanced TKA with a maintained joint line showed consistent coronal plane laxity throughout all flexion angles, while the native knee showed greater laxity at 90° than in mid-flexion. Further, as suggested by retrospective clinical reports, this cadaver study confirms that joint line elevation of only 4mm results in greater coronal plane laxity in mid-flexion. These finding suggest that maintaining the joint line in TKA is necessary to avoid increased mid-flexion, coronal plane laxity

Introduction. Surgeons commonly resect additional distal femur during primary total knee arthroplasty (TKA) to correct a flexion contracture to restore range of motion and knee function. However, the effect of joint line elevation on the resulting TKA kinematics including frontal plane laxity is unclear. Thus, our goal was to quantify the effect of additional distal femoral resection on passive extension and mid-flexion laxity. Methods. Six computational knee models with capsular and collateral ligament properties specific to TKA were developed and implanted with a contemporary posterior-stabilized TKA. A 10° flexion contracture was modeled by imposing capsular contracture as determined by simulating a common clinical exam of knee extension and accounting for the length and weight of each limb segment from which the models were derived (Figure 1). Distal femoral resections of 2 mm and 4 mm were simulated for each model. The knees were then extended by applying the measured knee moments to quantify the amount of knee extension. The output data were compared with a previous cadaveric study using a two-sample two-tailed t-test (p<0.05) [1]. Subsequently, varus and valgus torques of ±10 Nm were applied as the knee was flexed from 0° to 90° at the baseline, and after distal resections of 2 mm, and 4 mm. Coronal laxity, defined as the sum of varus and valgus angulation in response to the applied varus and valgus torques, was measured at 30° and 45°of flexion, and the flexion angle was identified where the increase in laxity was the greatest with respect to baseline. Results. With 2 mm and 4 mm of distal femoral resection, the knee extended an additional 4°±0.5° and 8°±0.75°, respectively (Figure 2). No significant difference was found between the extension angle predicted by the six models and the results of the cadaveric study after 2 mm (p= 0.71) and 4 mm (p= 0.47). At 2 mm resection, mean coronal laxity increased by 3.1° and 2.7° at 30° and 45°of flexion, respectively. At 4 mm resection, mean coronal laxity increased by 6.5° and 5.5° at 30° and 45° of flexion, respectively (Figures 3a and 3b). The flexion angle corresponding to the greatest increase in coronal laxity for 2 mm of distal resection occurred at 22±7° of flexion with a mean increase in laxity of 4.0° from baseline. For 4 mm distal resection, the greatest increase in coronal laxity occurred at 16±6° of flexion with a mean increase in laxity of 7.8° from baseline. Conclusion. A TKA computational model representing a knee with preoperative flexion contracture was developed and corroborated measures from a previous cadaveric study [1]. While additional distal femoral resection in primary TKA increases passive knee extension, the consequent joint line elevation induced up to 8° of additional coronal laxity in mid-flexion. This additional midflexion laxity could contribute to midflexion instability; a condition that may require TKA revision surgery. Further studies are warranted to understand the relationship between joint line elevation, midflexion laxity, and instability. For any figures or tables, please contact the authors directly

The elevation of the joint line is considered a possible cause of mid-flexion instability in total knee arthroplasty (TKA). The authors evaluated the effects of joint line change on mid-flexion stability in cruciate retaining TKA. Seventy-nine knees treated by cruciate retaining TKA using a modified balanced gap technique were included in this prospective study. After prosthesis insertion, valgus and varus stabilities were measured under valgus and varus stress using a navigation system at 0, 30, 60 and 90° of knee flexion. Changes of joint lines were measured preoperatively and postoperatively and compared. The knees were allocated to a “No change group (≤4mm, 62 patients)” or to an “Elevation group (>4mm, 17 patients)”. Medio-lateral stabilities (defined as the sums of valgus and varus stabilities measured intra-operatively) were compared in the two groups. The mean joint line elevation was 4.6mm in the no change group and 1.7mm in the elevation group. Mean medio-lateral stability at 30° of knee flexion was 4.8±2.3 mm in the no change group and 6.3±2.7 mm in the elevation group, and these values were significantly different (p = 0.02). However, no significant differences in medio-lateral stability were observed at other flexion angles (p>0.05). Knees with a < 5mm joint line elevation provide better mid-flexion stability after TKA. The results of this study suggest that a < 5mm elevation in joint line laxity is acceptable for cruciate retaining TKA

Functional joint stability and accurate component alignment are crucial for a successful clinical outcome after TKA. However, there are few methods to evaluate joint stability during TKA surgery. Activities of daily living often cause mechanical load to the knee joint not only in full extension but also in mid-flexion. Computer navigation systems are useful for intra-operative monitoring of joint positioning and movements. The purpose of this study was to compare the varus-valgus stability between knees treated with cruciate-retaining (CR) and posterior-stabilized (PS) TKA at different angles in the range of motion (ROM) especially in mid-flexion, using the navigation technique. Thirty two knees that underwent TKA with computer navigation technology (precisionN Knee Navigation Software version 4.0, Stryker, Kalamazoo, MI) were evaluated (CR:16; PS:16). The investigator gently applied physiologically allowable maximal manual varus-valgus stress to the knee without angular acceleration, while moving the leg from full extension to flexion, and the mechanical femoral-tibial angle was measured automatically by the navigation system at every 10 degrees throughout the ROM. This measurement cycle was repeated for 3 to 4 times, and maximal varus-valgus laxity was determined as the sum of varus and valgus stress angles for each of the predetermined knee flexion angles. The results of the navigated measurements were used to evaluate varus-valgus instability throughout the ROM and the differences in varus-valgus laxity between pre-TKA (Prior to bone cutting, after navigation registration and suturing of the joint capsule) and post-TKA(After confirming that the TKA components and inserts were firmly placed in an appropriate position, the surgical incision was completely closed). The differences in varus-valgus laxity between the CR and PS groups were compared using the Student's t-test. The knees examined showed the greatest preoperative laxity at 20 to 40 degrees of flexion, with no statistically significant difference between the CR and PS groups (See Figure 1). However, postoperative assessment revealed that PS knees had more varus-valgus laxity than CR knees at all ROM angles examined, and the differences were statistically significant in the flexion range of 10 to 70 degrees (See Figure.2). The differences between preoperative and postoperative joint laxity were analyzed separately for the CR and PS groups. After CR-TKA, joint laxity decreased across all degrees of knee flexion. The differences between preoperative and postoperative joint laxity were statistically significant for the flexion range of 110 to 120 degrees (See Figure.3). On the other hand, knees treated with PS-TKA showed an increase in joint laxity for the flexion range of 10 to 90 degrees. The differences between the preoperative and postoperative values were statistically significant for the flexion range of 10 to 20 degrees in PS-TKA (See Figure.4). We successfully evaluated varus-valgus laxity in this study using a navigation system. The results showed that PS knees had greater varus-valgus laxity than CR knees throughout the ROM, and the differences were statistically significant for the flexion range of 10 to 70 degrees. Altogether, we conclude that PS knees have more mid-flexion laxity than CR knees

Introduction. The aim of this study was to quantitatively analyze the amount coronal plane laxity in mid-flexion that occurs with a loose extension gap in TKA. In the setting of a loose extension gap, we hypothesized that although full extension is achieved, a loose extension gap will ultimately lead to increased varus and/or valgus laxity throughout mid flexion. Methods. After obtaining IRB approval, six fresh-frozen cadaver legs from hip-to-toe underwent TKA with a posterior stabilized implant (APEX PS OMNIlife Science, Inc.) using a computer navigation system equipped with a robotic cutting-guide, in this controlled laboratory cadaveric study. After the initial tibial and femoral resections were performed, and the flexion and extension gaps were balanced using navigation, a 4 mm distal recut was made in the distal femur to create a loose extension gap (using the same thickness of polyethylene as the well-balanced case). Real implants were used in the study to eliminate error in any laxity inherent to the trials. The navigation system was used to measure overall coronal plane laxity by measuring the mechanical alignment angle at maximum extension, 30, 45, 60 and 90 degrees of flexion, when applying a standardized varus/valgus load of 9.8 [Nm] across the knee using a 4 kg spring-load located at 25 cm distal to the knee joint line. (Figure 1). Coronal plane laxity was defined as the absolute difference (in degrees) between the mean mechanical alignment angle obtained from applying a standardized varus and valgus stress at 0, 30, 45, 60 and 90 degrees. Each measurement was performed three separate times. Two tailed student t-tests were performed to analyze whether there was difference in the mean mechanical alignment angle at 0°, 30°, 45°, 60°, and 90° between the well balanced scenario and following a 4 mm recut in the distal femur creating a loose extension gap. Results. In the setting of a loose extension gap (4 mm distal recut), overall coronal-plane laxity was increased by a mean of 3.6° at 30° of flexion, 3.4° at 45° of flexion, and 2.8° at 60° of flexion (p < 0.05 for each flexion angle). (Figure 2) However, there was no difference in coronal plane laxity between the well-balanced TKA and the TKA with a loose extension gap at 0° and 90° of flexion, when applying a standardized varus and valgus load. Conclusions. Using a reliable, accurate, and reproducible method of measuring coronal plane laxity, we have shown that in the setting of a loose extension gap during total knee arthroplasty, coronal plane laxity will be significantly higher in mid-flexion compared to the well balanced state

Introduction. The aim of this study was to quantitatively analyze the amount coronal plane laxity in mid-flexion that occurs in a well-balanced knee with an elevated joint line of 4 mm. In the setting an elevated joint line, we hypothesized that we would observe an increased varus and/or valgus laxity throughout mid flexion. Methods. After obtaining IRB approval, nine fresh-frozen cadaver legs from hip-to-toe underwent TKA with a posterior stabilized implant (APEX PS, OMNIlife Science, Inc.) using a computer navigation system equipped with a robotic cutting-guide, in this controlled laboratory cadaveric study. After the initial tibial and femoral resections were performed, the flexion and extension gaps were balanced using navigation, and a 4 mm recut was made in the distal femur. The remaining femoral cuts were made, the femoral component was downsized by resecting an additional 4 mm of bone off the posterior condyles, and the polyethylene was increased by 4 mm to create a situation of a well-balanced knee with an elevated joint line. Real implants were used in the study to eliminate any inherent error or laxity in the trials. The navigation system was used to measure overall coronal plane laxity by measuring the mechanical alignment angle at maximum extension, 30, 45, 60 and 90 degrees of flexion, when applying a standardized varus/valgus load of 9.8 [Nm] across the knee using a 4 kg spring-load located at 25 cm distal to the knee joint line (Figure 1). Coronal plane laxity was defined as the absolute difference (in degrees) between the mean mechanical alignment angle obtained from applying a standardized varus and valgus stress at 0, 30, 45, 60 and 90 degrees. Each measurement was performed three separate times. Two tailed student t-tests were performed to analyze whether there was difference in the mean mechanical alignment angle at 0°, 30°, 45°, 60°, and 90° between the well balanced scenario and following a 4 mm joint line elevation with an otherwise well balanced knee. Results. In the setting of a 4 mm elevated joint line, overall coronal-plane laxity was increased by a mean of 1.5° at 45° of flexion, and 1.3° at 60° of flexion (p < 0.05 for each flexion angle). (Figure 2) However, there was no difference at 0° and 90° in the coronal plane laxity between the well-balanced TKA and the TKA that was well balanced but had a 4 mm elevated joint line. Conclusions. Using a reliable, accurate, and reproducible method of measuring coronal plane laxity, we have shown that in the setting of a an elevated joint during total knee arthroplasty, regardless if the knee is well balanced in full extension and 90° of flexion, coronal plane laxity will be significantly higher in mid-flexion compared to the well balanced state

Knee replacements may be unstable in the: 1. Plane of motion instability, due to recurvatum or buckling (in flexion). 2. Coronal plane or varus-valgus instability and 3. Flexed position. The third, flexion instability, has been well described and is characterised clinically by early, easy, superior flexion that is then compromised by difficulties with ascending and descending stairs, recurrent effusions and peri-articular tenderness. This “flexion instability” results generally from a flexion gap that is more spacious than the extension gap, where the polyethylene insert has been selected to permit full extension. The term “mid-flexion” instability should not be used as a synonym for “flexion instability”. The concept of mid-flexion instability implies that the knee is stable in extension and stable in flexion (90 degrees) but unstable at points in between. The most common error in assessment probably occurs when surgeons observe stability to varus-valgus stress with the knee locked in full extension, where it is not appreciated that the posterior structures are tight and stabilising the knee. Once the knee if flexed enough to relax these structures, the true “flexion instability is revealed. This is not “mid-flexion” instability. It is conceivable, that an arthroplasty might be designed where the geometry of the femoral condylar curve is such a large, recessed radius that the collateral ligaments are tight in both full extension and 90 degrees of flexion, but unstable in between. There have been marketing allegations that one product or another has been designed in a way to result in “mid-flexion instability. The only published information is based on finite element analysis models. There is scant literature on “mid-flexion” instability”. Laboratory investigations with cadavers, concluded that proximal elevation of the joint line may create “mid-flexion” instability as a result of altering collateral ligament function. Computer models have questioned this effect. One clinical report describes “mid-flexion” (rotational) instability in a revision arthroplasty. So-called “anatomic alignment”, posterior stabilization and resection of distal femur to correct flexion contractures have been alleged to cause “mid-flexion” instability

Abstract. Introduction. Mid-flexion instability may cause poor outcomes following TKA. Surgical technique, patient-specific factors, and implant design could all contribute to it, with modelling and fluoroscopy data suggesting the latter may be the root cause. However, current implants all pass the preclinical stability testing standards, making it difficult to understand the effects of implant design on instability. We hypothesized that a more physiological test, analysing functional stability across the range of knee flexion-extension, could delineate the effects of design, independent of surgical technique and patient-specific factors. Methods. Using a SIMvitro-controlled six-degree-of-freedom robot, a dynamic stability test was developed, including continuous flexion and reporting data in a trans-epicondylar axis system. 3 femoral geometries were tested: gradually reducing radius, multi-radius and single-radius, with their respective tibial inserts. 710N of compression force (body weight) was applied to the implants as they were flexed from 0–140° with three levels of anterior/posterior (AP) tibial force applied (−90N,0N,90N). Results. While in static tests, the implants performed similarly, functional stability testing revealed different paths of motion and AP laxities throughout the flexion cycle. Some designs exhibited mid-flexion instability, while others did not: the multi-radius design allowed increased AP laxity as it transitioned to each arc of reduced femoral component radius; the single-radius design had low tibial bearing conformity, allowing 16mm difference in the paths of mid-flexion versus extension motion. Conclusions. Preclinical lab testing reveals functional differences between different design philosophies. Implant design impacts kinematics and mid-flexion stability, even before factoring in surgical technique and patient-specific factors

The June 2023 Knee Roundup. 360. looks at: Cementless total knee arthroplasty is associated with early aseptic loosening in a large national database; Is cementless total knee arthroplasty safe in females aged over 75 years?; Could novel radiological findings help identify aseptic tibial loosening?; The Attune cementless versus LCS arthroplasty at introduction; Return to work following total knee arthroplasty and unicompartmental knee arthroplasty; Complications and downsides of the robotic total knee arthroplasty; Mid-flexion instability in kinematic alignment better with posterior-stabilized and medial-stabilized implants?; Patellar resurfacing does not improve outcomes in modern knees

The April 2023 Knee Roundup. 360. looks at: Does bariatric surgery reduce complications after total knee arthroplasty?; Mid-flexion stability in total knee arthroplasties implanted with kinematic alignment: posterior-stabilized versus medial-stabilized implants; Inflammatory response in robotic-arm-assisted versus conventional jig-based total knee arthroplasty; Journey II bicruciate stabilized (JII-BCS) and GENESIS II total knee arthroplasty: the CAPAbility, blinded, randomized controlled trial; Lifetime risk of revision and patient factors; Platelet-rich plasma use for hip and knee osteoarthritis in the USA; Where have the knee revisions gone?; Tibial component rotation in total knee arthroplasty: CT-based study of 1,351 tibiae

Aims. This study aims to investigate the effects of posterior tibial slope (PTS) on knee kinematics involved in the post-cam mechanism in bi-cruciate stabilized (BCS) total knee arthroplasty (TKA) using computer simulation. Methods. In total, 11 different PTS (0° to 10°) values were simulated to evaluate the effect of PTS on anterior post-cam contact conditions and knee kinematics in BCS TKA during weight-bearing stair climbing (from 86° to 6° of knee flexion). Knee kinematics were expressed as the lowest points of the medial and lateral femoral condyles on the surface of the tibial insert, and the anteroposterior translation of the femoral component relative to the tibial insert. Results. Anterior post-cam contact in BCS TKA was observed with the knee near full extension if PTS was 6° or more. BCS TKA showed a bicondylar roll forward movement from 86° to mid-flexion, and two different patterns from mid-flexion to knee extension: screw home movement without anterior post-cam contact and bicondylar roll forward movement after anterior post-cam contact. Knee kinematics in the simulation showed similar trends to the clinical in vivo data and were almost within the range of inter-specimen variability. Conclusion. Postoperative knee kinematics in BCS TKA differed according to PTS and anterior post-cam contact; in particular, anterior post-cam contact changed knee kinematics, which may affect the patient’s perception of the knee during activities. Cite this article: Bone Joint Res 2020;9(11):761–767

Abstract. Introduction. This study compared biomechanical and functional parameters of a total knee arthroplasty (TKA) implant (Cemented Zimmer Hi-Flex) against healthy older adults to determine whether knee biomechanics was restored in this patient population. Methodology. Patients with a primary TKA and healthy adults >55 years old with no musculoskeletal deficits or arthritis participated. Bilateral knee range of motion (RoM) was assessed with a goniometer, then gait patterns were analysed with a 3D motion-capture system. An arthrometer then quantified anterior-posterior laxity of each knee. Statistical analyses were performed in SPSS (α=0.05; required sample size: n=21 per group). Results. 25 knees were replaced in 21 patients. Nine presented with fixed flexion deformities (FFD) (13.3±5.6°). FFDs were abolished intraoperatively, and the average flexion increased from 124.8±9.1° to 130.9±5.8°. At 9.6±3.2 years postoperatively, the patients achieved poorer RoM than healthy controls (n=23); p<0.0001. These differences were due to limited flexion in the knee. Patients also failed to achieve the same degree of flexion as controls bilaterally during gait. No differences were observed during mid-flexion; a state that has been associated with instability (p=0.614). There were no differences between groups in knee laxity. Conclusion. Patients in this study had similar gait patterns to healthy older adults during mid-flexion, and were no more likely to exhibit anterior-posterior translation of the knee >7mm; a known risk factor of instability. However, the flexion range was poorer. This led to bilateral pathological knee flexion patterns during gait. Further research should identify the cause of these limitations

Introduction. Acquiring adaptive soft-tissue balance is one of the most important factors in total knee arthroplasty (TKA). However, there have been few reports regarding to alteration of tolerability of varus/valgus stress between before and after TKA. In particular, there is no enough data about mid-flexion stability. Based on these backgrounds, it is hypothesized that alteration of varus/valgus tolerance may influence post-operative results in TKA. The purpose of this study is an investigation of in vivo kinematic analyses of tolerability of varus/valgus stress before and after TKA, comparing to clinical results. Materials and Methods. A hundred knees of 88 consecutive patients who had knees of osteoarthritis with varus deformity were investigated in this study. All TKAs (Triathlon, Stryker) were performed using computer assisted navigation system. The kinematic parameters of the soft-tissue balance, and amount of coronal relative movement between femur and tibia were obtained by interpreting kinematics, which display graphs throughout the range of motion (ROM) in the navigation system. Femoro-tibial alignments were recorded under the stress of varus and valgus before the procedure and after implantation of all components. In each ROM (0, 30, 60, 90, 120 degrees), the data of coronal relative movement between femur and tibia (tolerability) were analyzed before and after implantation. Furthermore, correlations between tolerability of varus/valgus and clinical improvement revealed by ROM and Knee society score (KSS) were analyzed by logistic regression analysis. Results. Evaluation of soft tissue balance with navigation system revealed that the tolerance of coronal relative movement between femur and tibia (varus/valgus) after implantation was significantly decreased compared with before implantation even in mid-flexion range. There were no significant correlations between tolerability of coronal relative movement and improvement of extension range and KSS. However, mid-flexion tolerability showed negative correlation with flexion range. Discussion. One of the most important principles for ligament balancing in TKA for varus knees is involved that the medial extension gap should be within 1–3mm to avoid flexion contracture and a feeling of instability, the medial flexion gap should be equal or 1–2mm larger to the medial extension gap, and lateral extension laxity up to 5 degrees is acceptable. However, there have been few reports measuring laxity from 30 to 60 degrees. In this study, the tolerance of coronal relative movement was significantly limited even in mid-flexion. However, mid-flexion tightness was not significantly correlated with clinical results except for flexion range. This result might be suggested that high tolerability of coronal relative movement in mid-flexion range may lead to widening of flexion range of motion of the knee after TKA. For any figures or tables, please contact authors directly

Introduction/Aim. Mid-flexion instability is a well-documented, but often poorly understood cause of failure of TKA. NAVIO robotic-assisted TKA (RA-TKA) offers a novel, integrative approach as a planning, execution as well as an evaluation tool in TKA surgery. RA-TKA provides a hybrid planning technique of measured resection and gap balancing- generating a predictive soft-tissue balance model, prior to making cuts. Concurrently, the system uses a semi-active robot to facilitate both the execution and verification of the plan, as it pertains to both the static and dynamic anatomy. The goal of this study was to assess the ability of the NAVIO RA-TKA to plan, execute and deliver an individualized approach to the soft-tissue balance of the knee, specifically in the “mid-flexion” arc of motion. Materials and Methods. Between May and September 2018, 50 patients underwent NAVIO RA-TKA. Baseline demographics were collected, including age, gender, BMI, and range of motion. The NAVIO imageless technique was used to plan the procedure, including: surface-mapping of the static anatomy; objective assessment of the dynamic, soft-tissue anatomy; and then application of a hybrid of measured-resection and gap-balancing technique. Medial and lateral gaps as predicted by the software were recorded throughout the entire arc of motion at 15° increments. After executing the plan and placing the components, actual medial and lateral gaps were recorded throughout the arc of motion. Results. In the assessment of coronal-plane balance, the average deviation from the predicted plan between 0–90° was 0.9mm in both the medial and lateral compartments (range 0.5–1.2mm). In the mid-flexion arc (15–75°), final soft-tissue stability was within 1.0mm of the predictive plan (range 0.9–1.2mm). Discussion/Conclusions. In this study, NAVIO RA-TKA demonstrated a highly accurate and reproducible surgical technique to plan, execute and verify a balanced a soft-tissue envelope in TKA. Objective soft-tissue balancing of the TKA can now be performed, including the mid-flexion arc of motion. Further analysis can determine if these objective measurements will translate into improved patient-reported outcome scores