Aims. Osteoarthritis (OA) is the most prevalent systemic musculoskeletal disorder, characterized by articular cartilage degeneration and subchondral bone (SCB) sclerosis. Here, we sought to examine the contribution of accelerated growth to OA development using a murine model of excessive longitudinal growth. Suppressor of cytokine signalling 2 (SOCS2) is a negative regulator of growth hormone (GH) signalling, thus mice deficient in SOCS2 (Socs2. -/-. ) display accelerated bone growth. Methods. We examined vulnerability of Socs2. -/-. mice to OA following surgical induction of disease (destabilization of the medial meniscus (DMM)), and with ageing, by histology and micro-CT. Results. We observed a significant increase in mean number (wild-type (WT) DMM: 532 (SD 56); WT sham: 495 (SD 45); knockout (KO) DMM: 169 (SD 49); KO sham: 187 (SD 56); p < 0.001) and density (WT DMM: 2.2 (SD 0.9); WT sham: 1.2 (SD 0.5); KO DMM: 13.0 (SD 0.5); KO sham: 14.4 (SD 0.7)) of
Objectives. The aim of this experimental study on New Zealand’s white rabbits
was to investigate the transplantation of autogenous growth plate
cells in order to treat the injured
Objectives. The aim of this study was to examine whether asymmetric loading
influences macrophage elastase (MMP12) expression in different parts
of a rat tail intervertebral disc and
Chondromodulin-I (ChM-I) is a bifunctional autocrine regulator of cartilage, initially isolated from fetal bovine epiphyseal cartilage. 1. ChM-I stimulates matrix synthesis of chondrocytes, but inhibits the growth of endothelial cells. 1,. 2. thus ChM-I may be one of the anti-angiogenic molecules present in cartilage. In fetal bovine bone, ChM-I was expressed by all epiphyseal and
Cohort studies in humans have suggested that the peak bone mass attained at skeletal maturity may be programmed in utero. To investigate which aspects of bone development might be influenced in utero, we utilised a rat model of maternal protein insufficiency, which has previously been used to demonstrate the fetal origin of adult hypertension. In rodents, a
INTRODUCTION. Endochondral ossification in the
Physeal bar resection for partial
Introduction. Kinematically or anatomically aligned total knee arthroplasty (TKA) has been reported to provide improved clinical outcomes by replicating patient's original joint line [1][2]. It has been known that tibial (joint line) varus varies among patients, and the tibial varus would increase over progression of arthritis and bone remodeling. For those patients with significant deformity, the current tibial varus may significantly differ from its pre-diseased state. In this exploratory study, geometry and alignment of the tibial
Purposes:. See if permanent damage of the
Rodents are often used as preclinical models for investigating the biomechanical consequences of spinal pathologies and interventions.
Introduction: In the
The
Problems of vertebral
Introduction and Aims: A previous study showed the inhibitory effect of 30% metaphyseal lengthening on tibial growth (Lee 1993). This study was to investigate the effect of 30% diaphyseal lengthening of tibia on tibial
In the pubertal
Introduction. Design evolution of total knee arthroplasty (TKA) has improved implant durability and clinical outcomes. However, it has been reported that some patients have limited satisfaction with their operated knees [1]. In view of better patient satisfaction, there have been growing interests in anatomically aligned TKA. The anatomically aligned TKA technique aims to replicate natural joint line of the patients [2][3]. However, restoration of natural joint line may be difficult for the knees with severe deformity, as their joint alignment with respect to bony landmarks at a time of surgery may be critically different from their pre-diseased state. The purpose of this study is to investigate alignment of the tibial
Introduction: Prior to skeletal maturity temporary hemiepiphyseal stapling is a treatment method for angular deformities of long bones. The purpose of this study is to investigate the effects of temporary hemiepiphyseal stapling on the bone geometry and histology of physis. Materials &
Methods: Proximal medial epipyseal stapling of the right tibia were done in 46 New Zealand rabbits. 23 of them were euthanized at the end of 3 weeks. For the remaining 23 rabbits staples were fixed subperiostally (group A) in 11, and extraperiosteally (group B) in 12 rabbits. After 3 weeks the staples removed and the rabbits were euthanized at the end of 6 weeks. Bromodeoxyuridine used to evaluate cellular activity of the
Aim: To review the outcome following
Introduction and aims.
Aim: Unicameral bone cysts are difficult to treat as partial cyst healing may reverse and it may be difficult to assess between active and latent types. Materials and Methods: 19 patients with unicameral bone cysts were reviewed with a mean age of 8.5 years (16 males and 3 females). These 19 patients were reviewed over a period of fifteen years and all except one, had an active cyst abutting the