Wear measurements of 100 explanted hips have been carried out on a Taylor Hobson 365 Roundness Machine using the LIRC Wear Protocol. It was found that 50% of explanted cups were wearing less than 5 μm/year and 60% of components were wearing less than 10 μm/year. Wear tests on hip joint simulators predict wear rates between 2 and 8 μm/year. However, 6% of cups are wearing faster than 100 μm/year, with 16% of cups have wear patches deeper than 100 μm and that 4% have a wear patch deeper than 300 μm.
Cup position is an important factor, all of the high wearing components are outside the Lewinick’s Box, however it is shown that mal position is does not always lead to extreme wear. Further analysis is taking place to calculate the size of the contact patch between head and cup (based on patient data and biomechanics) and the proximity of the contact patch to the edge of the cup.
High Tibial Osteotomy (HTO) is a recognised method of correction for knee joint malalignment and unicom-partmental osteoarthritis. Long-term results of this technique have been reported and are favourable. Good results have also been reported with Autologous Chondrocyte Implantation (ACI-C, MACI). Malalignment, if present, should be corrected when ACI is performed. Although results have been reported for either procedure separately, the outcomes of combined HTO-ACI remain unreported. The aim of this study was to evaluate functional outcome in patients undergoing combined HTO-ACI procedures. Twenty three patients undergoing a combined ACI-HTO procedure were identified retrospectively from a larger trial of patients undergoing ACI for symptomatic chondral defects. The mean age of the patients was 36 (28 – 49). The mean follow-up was 54 months (12 – 108) and mean defect size was 689mm2 (range 350 – 1200). Nine patients had ACI-C and HTO, the remainder having MACI and HTO. Pre and post-operative assessment was carried out using the Visual Analogue Score (VAS), the Bentley Functional Rating Score and the Modified Cincinnati Rating System. The Mean VAS score improved from 7.4 (4 – 10) pre-operatively to 2.9 (0 – 6) post-operatively at the latest follow-up (p<
0.0001). The Bentley Functional Rating Score improved from 2.9 (2 – 4) to 1.8 (0 – 4), which was statistically significant (p<
0.0001). The Modified Cincinnati Rating System improved from 35.2 (20 – 49) pre-operatively to 68.7 (46 – 85) post-operatively (p<
0.0001). Fourteen patients underwent biopsy of the graft site at a mean of 13.7 months: 21% of biopsies were hyaline-like cartilage, 36% were mixed hyaline/fibrocartilage, 29 % were fibrocartilage and 14% were fibrous tissue. Combining high tibial osteotomy with autologous chondrocyte implantation is an effective method of decreasing pain and increasing function in the short term. Further evaluation of this procedure is required.
High tibial osteotomy (HTO) is a recognised method of correction for knee joint malalignment and unicompartmental osteoarthritis. The long term results of this technique have been reported and are favourable. Autologous chondrocyte implantation (ACI-C, MACI) has also been reported to have good results It is advised that malalignment, if present, should be corrected if ACI is to be performed. Although results have been reported for either procedure separately, the outcomes of combined HTO-ACI remain unreported. To evaluate functional outcome in a group of patients undergoing combined HTO-ACI procedures. Twenty three patients undergoing a combined ACI-HTO procedure were identified retrospectively from a larger trial of patients undergoing ACI for symptomatic chondral defects. The mean follow-up was 54 months (range 12 – 108) and the mean defect size was 689 mm2 (range 350 – 1200). Nine patients had ACI-C and HTO, the remainder having MACI and HTO. Pre and postoperative assessment was carried out using the Visual Analogue Score (VAS), the Bentley Functional Rating Score and the Modified Cincinnati Rating System. The Mean VAS score improved from 7.4 pre-operatively to 2.9 post-operatively (p<
0.0001). The Bentley Functional Rating Score improved from 2.9 to 1.8 (p<
0.0001) whilst the Modified Cincinnati Rating System improved from 35.2 pre-operatively to 68.7 post-operatively (p<
0.0001). There was no significant difference between ACI-C and MACI. Two patients developed a non union at a mean of 13 months and a further two patients had a failure of the chondrocyte graft at a mean of 22.5 months. Combining high tibial osteotomy with autologous chondrocyte implantation is an effective method of decreasing pain and increasing function at mean of 54 months follow-up. Further follow-up is required to assess the long term outcomes of these combined procedures.
Non-invasive expandable prostheses for limb salvage tumour surgery were first used in 2002. These implants allow ongoing lengthening of the operated limb to maintain limb-length equality and function while avoiding unnecessary repeat surgeries and the phenomenon of anniversary operations. A large series of skeletally immature patients have been treated with these implants at the two leading orthopaedic oncology centres in England (Royal National Orthopaedic Hospital, Stanmore, and Royal Orthopaedic Hospital, Birmingham). An up to date review of these patients has been made, documenting the relevant diagnoses, sites of tumour and types of implant used. 74 patients were assessed, with an age range of 7 – 16 years and follow up range of 4 – 88 months. We identified five problems with lengthening. One was due to soft tissue restriction which resolved following excision of the hindering tissue. Another was due to autoclaving of the prosthesis prior to insertion and this patient, along with two others, all had successful further surgery to replace the gearbox. Another six patients required mechanism revision when the prosthesis had reached its maximal length. Complications included one fracture of the prosthesis that was revised successfully and six cases of metalwork infection (two of which were present prior to insertion of the implant and three of which were treated successfully with silver-coated implants). There were no cases of aseptic loosening. Overall satisfaction was high with the patients avoiding operative lengthening and tolerating the non-invasive lengthenings well. Combined with satisfactory survivorship and functional outcome, we commend its use in the immature population of long bone tumour cases.
Non-bacterial osteitis (NBO), a term referring to sterile bone lesions with non-specific histopathological features of inflammation, may be either uni- or multifocal, acute (6 months) or chronic, and recurrent. Only when the condition is chronic, recurrent and multifocal is it appropriate to use the term chronic recurrent multifocal osteomyelitis (CRMO). We present our clinical experience as the largest reported series of children with NBO to date. Of 41 children (2–16 years) diagnosed with NBO in our institution over the last 6 years, 21 (51%) had recurrent disease and 18 of 41 (44%) had multifocal disease. The most common bones affected were the clavicle, femur and tibia (in order of decreasing prevalence) accounting for 44 (63%) of a total of 70 lesions. Only one individual had SAPHO syndrome and no other patients had evidence of bowel or skin disease. In the absence of evidence for an infective aetiology, we recommend non-steroidal anti-inflammatory agents as first line therapy, and bisphosphonates only in cases of resistant disease. On the basis of our findings we propose a patient questionnaire and protocol for investigating and managing patients who present to orthopaedic surgeons with NBO. We predict that this will benefit patients with this disorder by providing valuable information about the pathogenesis, clinical outcome and response to treatment. In the future, clarification of the pathogenesis of this disease will undoubtedly help rationalise the therapeutic approach improving both quality of life and outcome for these patients.
Of the 27 repeat biopsies a positive histological diagnosis was obtained in 22 patients. The remaining 5 were again non-diagnostic giving a total of 98 patients being treated definitively without a tissue diagnosis. Of these 98 cases, 39 (40%) were treated non-operatively, 37 (38%) had curettage and 22 (22%) underwent wide excision. In the curettage group 33 out of 37 patients had a benign tumour on final histology. Four patients turned out to have intermediate/high grade tumours and subsequently underwent wide excision. In the wide excision group, 17 out of 22 patients had an intermediate/high grade tumour on final histology. Five patients underwent an unnecessarily wide excision of a benign lesion. None of the patients treated non-operatively turned out to have a tumour.
To determine the diagnostic performance of image-guided percutaneous core needle biopsy (CNB) in patients presenting with pathologic fractures of the appendicular skeleton. To determine factors associated with non-diagnostic biopsy and identify cases which should be considered for primary open biopsy. A retrospective audit identified 129 consecutive patients presenting with pathological fractures to a specialist orthopaedic oncology unit over a 9 year period. All patients underwent percutaneous CNB using CT (n=98), fluoroscopy (n=15) or US (n=16) guidance. In all cases MRI or CT was available prior to biopsy to assess the presence and degree of extra-osseous tumour mass. The resulting sample was classified as diagnostic (Group 1) or non-diagnostic (Group 2) on histopathological study. Diagnostic performance was evaluated on the basis of the diagnostic yield and accuracy; these were related to the site of the lesion and presence/absence of extra-osseous mass. Of 129 biopsies, 99 (77%) were classified as Group 1 and 30 (23%) as Group 2. The commonest sites of pathological fracture without associated soft tissue component and resulting in a non-diagnostic biopsy were the proximal femur and proximal humerus. The average cross-sectional diameter of lesions in Group 1 was 5.7 x 5.9cm. Of the 30 lesions comprising Group 2, no soft tissue component was identified on pre-biopsy cross-sectional imaging in 27 lesions (90%) whereas the remaining 3 (10%) showed a smaller extra-osseous soft tissue component compared to the lesions in Group 1. Image-guided percutaneous CNB is a reliable method for obtaining a tissue diagnosis in patients presenting with a pathologic fracture of the appendicular skeleton with high accuracy rate. However, those lesions which are purely intra-osseous or have only very small extra-osseous components are likely to be associated with a non-diagnostic biopsy, and should be considered for a primary open procedure.
Elastofibroma dorsi is a rare, benign, slow-growing ‘pseudotumour’ classically presenting as an ill defined mass at the inferior pole of the scapula. Typical symptoms include mass, pain, scapular snapping and impingement like features. There is a predilection for females after the fifth decade of life. The aetiology is unclear. We identified 15 patients (21 tumours) with a diagnosis of elastofibroma. Seven lesions were found on the left side and fourteen on the right; bilateral lesions were found in six patients. The male:female ratio was eight:seven and mean age at presentation was 60.9 years (range 40 – 71). The mean duration of symptoms (most commonly pain, mass and scapular snapping) prior to presentation was 25.8 months. Eighteen tumours were excised with a mean follow-up of 4.2 years (0.25–16). Four lesions were diagnosed by combined MRI and CT guided biopsy, the remainder identified using MRI alone. All patients were asked specifically about symptoms, occupation, family history and employment history (including hobbies). Pain was assessed using the Visual Analogue Score (VAS) and functional outcome using the Stanmore Percentage of Normal Shoulder Assessment (SPONSA) Score. Range of forward flexion of the shoulder joint was also assessed. In the operative group, the mean VAS score improved from 4.6 (0–10) pre-operatively to 2.5 (0–8) post-operatively. Mean SPONSA scores improved from 61.5% (20 – 100) to 81.8% (30 – 100). Mean pre-operative forward flexion was 135 degrees (70 – 180), this improved to 166 degrees (100 – 180) post-operatively. A high number of patients had been involved in occupations involving heavy lifting. MRI had a 100% sensitivity in identifying elastofibroma when correlated with histopathological evaluation. This series demonstrates that elastofibroma may be reliably diagnosed using MRI alone and, in the symptomatic patient, pain and function may be improved through operative excision.
Pre operative oxford, Harris and WOMAC scores in the THA group were 41.1, 46.4 and 50.9 respectively while the post operative scores were 14.8, 95.8 and 5.0. In the HR group, pre- operative scores were 37.0, 54.1 and 45.9 respectively compared to 15.0, 96.8 and 6.1 post operatively. The degree of improvement was similar in both groups.
There were 6 complications (3.8%) in this series; a periprosthetic fracture of the femoral diaphysis (1), posterior dislocation (2), failure secondary to aseptic loosening of the implant (1) and deep vein thromboses (2)
Within a study group of 102 consecutive patients diagnosed at a supra-regional bone tumour unit with chondrosarcoma of the femur, tibia or humerus, an association with previously treated breast cancer was noted. There were 58 female patients and 44 male patients. The study group contained six females (10%, mean age 53 years) who had previously been treated for breast cancer, a higher proportion than would be expected. They were referred following identification of a solitary area of increased activity on routine screening with isotope bone scan, presumed to be a solitary bony metastasis. Most (86%) of this breast carcinoma sub-group had developed low-grade bone chondrosarcoma (Trojani grade 0.5-I) and only one case (14%) had developed high-grade chondrosarcoma (Trojani grade II-III). A suspicious long bone lesion on bone scan in a patient with a past medical history of breast cancer must, therefore, not be assumed to be a metastasis without further investigation; the possibility of a chondral lesion should be considered. It is important that patients receive a full multidisciplinary team investigation prior to treatment in order to obtain the correct tissue diagnosis, as the management of these conditions is often different. Our study suggests there may be a relationshipbetween patients previously treated for breast cancer and the development of subsequent chondrosarcoma.
Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue neoplasm most commonly presenting in young to middle-aged adults. LGFMS is an indolent tumour with a deceptively benign histological appearance. Local recurrences are not uncommon and the tumours can metastasise. A particular gene translocation, FUS-CREB3L2, has been shown to occur commonly in cases of LGFMS. The literature suggests that the FUS-CREB3L2 fusion-gene is a specific marker for LGFMS. We report the cytogenetic analysis of 29 cases of LGFMS, and clinical outcomes of 21 patients treated surgically between 1998 and 2008 at our regional bone and soft-tissue tumour centre. The mean age was 45.4 years. The most common location of tumours in our series was the lower limb. The mean follow-up was 30.1 months (range 0 to 125 months). To date, there have been no cases of local recurrence or metastasis. Fifteen of our patients (52.2%) were FUS-CREB3L2 translocation-positive. This suggests either that the translocation incidence in our LGFMS series is lower than other studies, or that reverse-transcriptase polymerase chain reaction (PCR) is substantially less sensitive than the literature suggests. The patients in this series testing positive presented at a younger age (38.2 years, compared to 45.6 years), and had larger tumours than their negative counterparts (mean diameter 97.6mm, compared to 65.2mm), although there was no difference in clinical outcome. We conclude that PCR testing for the FUS-CREB3L2 translocation is a useful tool for confirming the diagnosis of LGFMS, but has no role in predicting short-term clinical outcome. In our experience it is not necessary to perform wide excision, and marginal margins are adequate. Longer-term follow-up is required to elucidate whether the previously reported recurrence and metastasis rates are a true reflection of the nature of this tumour, and may identify differences in the long-term clinical outcome between translocation-positive and negative patients.
Granular Cell Tumours are rare mesenchymal soft tissue tumours that arise throughout the body and are believed to be of neural origin. They often present as an asymptomatic slow-growing benign solitary lesion but may be multifocal. One to two percent of cases are malignant and can metastasise. Described series in the literature are sparse. We examined our database and identified eleven cases in ten patients treated surgically and followed-up for a period of over six years (May 2002 to January 2009) in our regional bone and soft tissue tumour centre. Five tumours were located in the lower limb, four in the upper limb and two in the axial skeleton. Mean patient age was 31.2 years (range 8 to 55 years). Excision was complete in one case, marginal in five cases and intra-lesional in five cases. No specimens showed evidence of malignancy. No patients required postoperative adjuvant treatment. Mean follow-up was 19.3 months (range 1 to 37 months), with no cases of local recurrence. One case was multi-focal. Histopathological examination revealed the classical features of granular cell tumour in all cases. Typically, tumour cells were diffusely and strongly positive for S100 protein by immunohistochemistry, whereas the other markers tested were negative. We believe this case series to be the largest of its type in patients presenting to an orthopaedic soft tissue tumour unit. We present our findings and correlate it with findings of other series in the literature.
Retrieval study:
14 knee replacement components were retrieved after revision procedures. The average surface roughness (Ra) of the articulating regions of each condyle was measured by surface profilometry and compared to Ra of non-articulating regions, which acted as controls on each implant. In vitro testing:
Pin-on-plate testing of 6 paired CoCr pins and vacuum γ-irradiated UHMWPE discs was carried out under a force of 2.3kN at 1Hz to investigate how the articular Ra of CoCr pins varied with increasing number of cycles. Ra was measured at 0, 10, 100 and 1000 cycles using surface profilometry.
Retrieval analysis:
Average medial femoral condyle Ra was significantly greater than control Ra (p=0.040). Average lateral femoral condyle Ra was not significantly greater than control Ra (p=0.158). Significantly higher average Ra was seen on the medial condyles when compared with the lateral condyles (p <
0.05). 8/14 retrieved femoral components had ≥1 significantly roughened condyle (p<
0.05). In vitro testing:
At 100 and 1000 cycles the Ra of the CoCr pins was significantly greater than Ra at 0 cycles (p<
0.05).
Chondrosarcoma is the second most common primary malignant bone tumour. Distinguishing between grades is not necessarily straightforward and may alter the management of the disease. We evaluated the correlation between the pre-operative needle biopsy and excision biopsy histological grading of chondrosarcoma of the femur, tibia and humerus. A consecutive retrospective series of 100 patients with a histological diagnosis of chondrosarcoma was reviewed. Twenty-one patients were excluded because 20 had only excision biopsy and one had only the pre-operative biopsy on record, thus this series included 79 available cases. In 11 instances, there was a discrepancy in histological grade. Therefore, there was an 86% (68 out of 79) accuracy rate for pre-operative histological grading of chondrosarcoma, based on needle biopsy. However, the accuracy of the diagnostic biopsy to distinguish low-grade from high-grade was 90% (71 out of 79).
A novel adaptor was designed to correct for the differential radii and enable removal of the well fixed BHR socket with the explant. We present the results of our initial experience with this device.
The explant cup extractor was used with its standard centering head and curved blades. The size of the explanted cup, last reamer size and size of the implanted component were recorded
Medical records of children <
/=5 years, treated by the London sarcoma service for malignant primary bone tumours (average new cases osteosarcoma (OS)/Ewings sarcoma (ES), all ages: 125/year) between 1999 and 2009, were reviewed.
Our statistical analysis suggests that if time post implantation doubles then the likelihood of a favourable histological outcome increases significantly.
Complications developed in seven patients: two implants failed requiring revision, one peri-prosthetic fracture occurred, one developed a flexion deformity of 25 degrees at the knee joint, which was subsequently overcome and three died of disseminated disease.
Orthopaedic surgeons vary in their attitude towards resurfacing of the patella in total knee arthroplasty. Few studies are available to assess outcome and patient preference. We evaluated post-operative anterior knee pain and knee preference in patients with bilateral knee replacements and unilateral patellar resurfacing. We reviewed 30 patients who had undergone bilateral knee replacement with patellar resurfacing on only one side. Follow-up was from five to 12 years and the patients were assessed using the Knee Society rating, an anterior knee pain rating and a satisfaction score. Patients were also asked specifically if they had a preference for either knee. Assessment was performed without knowing which patella had been resurfaced. Fourteen patients (47%) favoured the resurfaced knee, six (20%) the un-resurfaced knee and 10 (33%) had no particular preference. The overall prevalence of anterior knee pain was 50% in the un-resurfaced cases (six mild, six moderate, three severe) and 20% in the resurfaced knees (four mild, two moderate). No significant difference was found between knee scores. Three un-resurfaced patellae have been secondarily resurfaced. This study shows a significant preference for the resurfaced side (p<
0.01), with a higher prevalence of anterior knee pain in non-resurfaced patellae (p<
0.05).
The five most common histopathological diagnoses were chondrosarcoma (9%), osteosarcoma (9%), meta-static renal carcinoma (8%), giant-cell tumour (6%), lymphoma (5%). 77% of biopsies yielded a tissue diagnosis. The remaining 23% underwent open biopsy, repeat image-guided needle biopsy or were not further investigated. In the 30 cases (23%) of non-diagnostic biopsies 80% of these lesions had no extra-osseous component to them and the remaining 20% had a very small extra-osseous component.
Our aim was to review the short-term clinical results of a single-institution cohort undergoing opening wedge high tibial osteotomy (HTO). We undertook a prospective clinical and radiographic review of our cohort of patients who had undergone opening wedge HTO for varus malalignment. The Cincinnati scoring system was used for objective assessment. Pre- and post-operative radiographs were evaluated and Blackburne-Peel (BP) and Insall-Salvati (IS) ratios recorded, as well as integrity of the lateral hinge. We reviewed 55 knees (51 patients: 34 men and 17 women; mean age, 44.2years; range 34–58years) followed up for a minimum 12 months (range, 12–62months). All patients had relief of pain, but six met our criteria of failed treatment where either revision fixation was required or proceeded to total knee arthroplasty for persisting symptoms. Cincinnati scores were 94.5% excellent (52/55) and 5.5% good (3/55) at 1 year, whilst at last follow-up they were 87.2% excellent (48/55), 9.1% good (5/55) and 3.6% fair (2/55). There was a significant improvement in mean American Knee Society score at 1 year and maintained at last follow-up (p<
0.05). Radiographically the lateral hinge was noted to be breached in 9.1% (5/55), but no incidence of non-union was identified. There was no significant change in IS index, however BP index diminished by a mean 15.3% (range, 7.4–28.2%). Medial opening wedge tibial osteotomy results in patellar infera, but successful clinical and functional outcomes have been demonstrated. The fact ther e is inconsistency between the two indices assessing patellar height ratio we believe reflects the inherent variability in the techniques employed. Distalisation of the tibial tubercle will mean the IS ratio remains unaffected, whilst the BP index more accurately demonstrates the lowering of patella relative to the joint line. However there may be other factors which are not immediately appreciated, such as changes in the tibial inclination or antero-posterior translation.
We retrospectively studied 67 patients who underwent proximal humeral replacement with the Bayley-Walker prosthesis, for tumour of the proximal humerus between 1997 and 2007. Of the 67 patients 10 were lost to follow up. Of the 41 surviving patients, function was assessed using the Musculoskeletal Tumour Society (MSTS) Score and the Toronto Extremity Salvage Score (TESS) questionnaire. 4 of the 41 patients received the new Bayley-Walker ‘captured’ proximal humeral replacement. The mean age was 46 years (7–87). The mean MSTS score at follow-up was 72.0 % and the mean TESS score was 77.2 %. The sub-group of 4 pts who received the new captured prosthesis had a mean MSTS score of 77.7 %. There was no mechanical failure of any prostheses in the follow up period. Endoprosthetic replacement for tumour of the proximal humerus with the Bayley-Walker prosthesis, is a reliable operation yielding reasonable functional results and good long-term prosthesis survivorship. The performance of this prosthesis is expected to improve further with the new ‘captured’ prosthesis.
Our aim was to review the short-term clinical results of a single-institution cohort undergoing opening wedge high tibial osteotomy (HTO). We undertook a prospective clinical and radiographic review of our cohort of patients who had undergone opening wedge HTO for varus malalignment. The Cincinnati scoring system was used for objective assessment. Pre- and post-operative radiographs were evaluated and Blackburne-Peel (BP) and Insall-Salvati (IS) ratios recorded, as well as integrity of the lateral hinge. We reviewed 55 knees (51 patients: 34 men and 17 women; mean age, 44.2years; range 34–58years) followed up for a minimum 12 months (range, 12–62months). All patients had relief of pain, but six met our criteria of failed treatment where either revision fixation was required or proceeded to total knee arthroplasty for persisting symptoms. Cincinnati scores were 94.5% excellent (52/55) and 5.5% good (3/55) at 1 year, whilst at last follow-up they were 87.2% excellent (48/55), 9.1% good (5/55) and 3.6% fair (2/55). There was a significant improvement in mean American Knee Society score at 1 year and maintained at last follow-up (p<
0.05). Radiographically the lateral hinge was noted to be breached in 9.1% (5/55), but no incidence of non-union was identified. There was no significant change in IS index, however BP index diminished by a mean 15.3% (range, 7.4–28.2%). Opening wedge HTO provides a means of relieving stress distribution through the medial tibiofemoral compartment and results in effective relief of symptoms with improvement in functional outcome and quality of life.
38 patients (41 knees) who received a primary SMILES knee prosthesis by one of the senior authors between 1990 and 2006 were retrospectively studied. Knee function was assessed pre and post-operatively using the Oxford knee score (0–48 scoring system) and the Knee Society Score. Patients receiving surgery for tumours were excluded. The main indications for primary SMILES were bone loss and ligamentous laxity.
2 patients died and 5 were lost to follow-up. 2 patients required revision surgery (one for infection and one for re-bushing). Post-operative complications included peroneal nerve palsy (1) and DVT (1). The mean Oxford knee score improved from 9 pre-op to 44 post-op, and the mean knee society score improved from 24 pre-op to 71 post-op. The average range of motion was 57 degrees pre-op and 88 degrees post-op.
linear wear rate (depth of the femoral head and acetabular socket wear patch/time from operation); the diagnosis and severity of ALVAL from histological sections of periprosthetic tissue (Wilhert grading system); pre-revision whole blood cobalt, and chromium levels using Inductively Coupled Plasma Mass Spectrometry. All implants and tissue samples were analysed against control samples from patients undergoing revision of MOM hips for fractured femoral neck or impingement.
1) observational study to analyse surgeon’s and anaesthetist’s attitude to transfusion 2) prospective study to analyse the influence of perioperative haemoglobin concentration (Hb) on post-operative fatigue, hand grip strength, duration of in-patient physiotherapy and post-operative morbidity score (POMS) and also the prognostic factors to predict functional recovery.
200 patients (88 THR, 99 TKR, 13 hip resurfacing) were evaluated. Blood Hb, hand grip strength and vigour scores using fatigue questionnaire were estimated both preoperatively and at 3 days following surgery. POMS and the required duration of in-patient physiotherapy were also noted. The protocol for blood transfusion was for those with Hb less than 8 g/dL and/or post-operative symptoms attributable to anaemia.
A greater fall in postoperative Hb correlated significantly with a greater reduction in post-operative vigour score (p=0.02). Also a greater fall in vigour score was found to correlate significantly with the duration of in-patient physiotherapy (p<
0.001). A reduction in Hb of >
4g/dL from the pre-operative Hb predicted a significantly higher reduction in vigour score (p=0.03). A weak correlation was seen between a fall in Hb and POMS (p=0.09). A higher pre-operative Hb did not reduce the required duration of in-patient physiotherapy (p=0.72). There was no correlation between post-operative Hb and POMS (p=0.21) or duration of in-patient physiotherapy (p=0.20). A higher pre-operative grip strength predicted an early date of discharge by the physiotherapists (p=0.02).
cell proliferation assays (3H-thymidine incorporation) and cytokines secretion (ELISA) following exposure to antigen challenge using Tetanus Toxoid and polyclonal mitogen phytohaemoagglutinin (PHA).
We aimed to determine whether proximal femoral bone remodelling, as measured by DEXA scan for each Gruen Zone, differed for 3 different femoral stem designs. These were:
Group 1 – Triple taper polished (C-stem J&
J DePuy) Group 2 – Double taper polished (TPS J&
J DePuy) Group 3 – Collared satin finish stem (Stanmore Biomet) Ethical Committee approval was obtained and all patients gave informed consent. All operations were performed by 3 surgeons using a standard lateral approach, third generation cementing technique and a standard post-operative regime. Seventy-five patients were randomised prospectively using a stratified randomisation programme for known risk factors in bone density. The randomisation was stratified by age, sex, Charnley Group (A or B), BMI and femoral neck bone mineral density. There were 25 patients in each Group, 5 patients did not have complete data sets and were therefore withdrawn from evaluation. The Groups were similar with regard to age, sex, BMI, BMD and Charnley Group. Patients were followed up at 3, 6, 12 and 24 months by Nurse Practitioners for clinical and radiological evaluation and DEXA scan at each time of follow-up. There were no catastrophic failures of sepsis or dislocation. All patients functioned well at 24 months by Harris Hip Score. The bone remodelling pattern will be described for each stem design. Findings are summarised thus. In the lateral Gruen Zones the triple taper and collared stem design faired better and both behaved differently to the double taper design. In Gruen Zone 7, all stems demonstrated reduced bone density as compared to pre-operative scans but this was less with the triple taper design.
The growth of the patients was an average 17cm. The graft diameters did not change despite large changes in graft length (average 145%). Most of the length gain was in the femur.
the influence of histology on durability of cartilage repair following collagen-covered autologous chon-drocyte implantation (ACI-C) in the knee. the relationship between macroscopic grading and durability of cartilage repair; and the relationship between macroscopic appearance and histology of repair tissue.
There was no correlation between the ICRS grading and MCRS either at one year (p=0.12) or at the latest follow-up (p=0.16). Also, the ICRS grading of the repair tissue did not correlate with its histological type (p=0.12).
A higher pre-operative Hb did not reduce the required duration of in-patient physiotherapy (p=0.72). There was no correlation between post-operative Hb and POMS (p=0.21) or required duration of in-patient physiotherapy (p=0.20). A higher pre-operative grip strength predicted an early date of discharge by the physiotherapists (p=0.02).