Lateral femoral cutaneous nerve (LFCN) injury is a complication after periacetabular osteo-tomy (PAO) using an anterior approach, which might adversely affect the outcome. However, no prospective study has assessed the incidence and severity of this injury and its effect on the clinical outcomes over a period of time for longer than one year after PAO. The aim of this study was to assess the incidence and severity of the symptoms of LFCN injury for ≥ three years after PAO and report its effect on clinical outcomes. A total of 40 hips in 40 consecutive patients who underwent PAO between May 2016 and July 2018 were included in the study, as further follow-up of the same patients from a previous study. We prospectively evaluated the incidence, severity, and area of symptoms following LFCN injury. We also recorded the clinical scores at one year and ≥ three years postoperatively using the 36-Item Short Form Health Survey (SF-36) and Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) scores.Aims
Methods
Injury of the lateral femoral cutaneous nerve (LFCN) is one of the known complications after periacetabular osteotomy (PAO) using anterior approach. We previously reported that the incidence of LFCN injury was 48% at 1 year after PAO. However, there was no study examining the sequential changes of LFCN injury status. In this study, we performed a prospective over 3-year follow-up study as to the incidence of LFCN injury as well as its clinical outcomes. This study included 40 consecutive hips in 40 patients (3 males and 37 females) who underwent PAO from May 2016 to July 2018. The mean age at surgery was 36.7 years (17 to 60). The mean observation period was 47.3 months (36 to 69). The incidence and severity of LFCN injury was evaluated, while clinical scores, including the Harris Hip Score (HHS), Short-Form 36 Health Survey (SF-36), and Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ), were also investigated. At 3 years after PAO, LFCN injury was observed in 13 of 40 (33%) patients, in which 7 patients who had a symptom at 1 year have completely recovered. There was no significant difference in the HHS and SF-36 between patients with and without LFCN injury at 3 years. Regarding the JHEQ, a significant difference was recognized in the patient satisfaction and mental score between patients with and without LFCN injury, but there were no significant differences in the other clinical scores. The incidence of LFCN injury gradually decreased to 33% at 3 years after CPO. LFCN injury did not influence the clinician-reported outcome, while it had a negative impact on patient satisfaction and mental score based on the patient-reported outcome.
Injury to the lateral femoral cutaneous nerve (LFCN) is one of the known complications after periacetabular osteotomy (PAO) performed using the anterior approach, reported to occur in between 1.5% and 65% of cases. In this study, we performed a prospective study on the incidence of LFCN injury as well as its clinical outcomes based on the Harris Hip Score (HHS), Short-Form 36 Health Survey (SF-36), and Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ). The study included 42 consecutive hips in 42 patients (three male and 39 female) who underwent PAO from May 2016 to July 2018. We prospectively evaluated the incidence of LFCN injury at ten days, three months, six months, and one year postoperatively. We also evaluated the clinical scores, including the HHS, SF-36, and JHEQ scores, at one year postoperatively.Aims
Methods
Indocyanine green (ICG) fluorescence angiography is an emerging technique that can provide detailed anatomical information during surgery. The purpose of this study is to determine whether ICG fluorescence angiography can be used to evaluate the blood flow of the rotator cuff tendon in the clinical setting. Twenty-six patients were evaluated from October 2016 to December 2017. The participants were categorized into three groups based on their diagnoses: the rotator cuff tear group; normal rotator cuff group; and adhesive capsulitis group. After establishing a posterior standard viewing portal, intravenous administration of ICG at 0.2 mg/kg body weight was performed, and fluorescence images were recorded. The time from injection of the drug to the beginning of enhancement of the observed area was measured. The hypovascular area in the rotator cuff was evaluated, and the ratio of the hypovascular area to the anterolateral area of the rotator cuff tendon was calculated (hypovascular area ratio).Objectives
Methods
Similar to the radiological findings in rapidly destructive arthrosis of the hip joint (RDA), subchondral insufficiency fracture of the femoral head (SIF) can result in progressive femoral head collapse of unknown etiology. We thus examined the osteoclast activity in hip joint fluid in SIF with progressive collapse in comparison to that in RDA. Twenty-nine hip joint fluid samples were obtained intraoperatively with whole femoral heads from 12 SIF patients and 17 RDA patients. SIF cases were classified into subgroups based on the presence of ≥2mm collapse on preoperative radiographs: SIF with progressive collapse (n=5) and SIF without progressive collapse (n=7). The levels of tartrate-resistant acid phosphatase (TRACP)-5b, interleukin-8, vascular endothelial growth factor (VEGF), and matrix metalloproteinase (MMP)-9 were measured. Numbers of multinuclear giant cells at the subchondral region were assessed histopathologically using mid-coronal slices of each femoral head specimen. Median levels of all markers and median numbers of multinuclear giant cells in SIF with progressive collapse were significantly higher than those in SIF without progressive collapse, while there were no significant differences in SIF with progressive collapse versus RDA. Regression analysis showed that the number of multinuclear giant cells correlated positively with the level of TRACP-5b in joint fluid. This study suggests an association of increased osteoclast activity with the existing condition of progressive collapse in SIF, which was quite similar to the findings in RDA. Therefore, high activation of osteoclast cell may reflect the condition of progressive collapse in SIF as well as RDA.
Osteonecrosis of the femoral head (ONFH) is an ischemic disorder that causes bone and bone marrow necrosis. In spite of many studies, the primary cause of ischemia is still unknown. The purpose of this study is to identify the susceptibility genes in ONFH. We performed a genome-wide association study (GWAS) in 1,602 ONFH cases and 60,000 controls. Stratified GWASs based on the 3 subgroups of ONFH (corticosteroids, alcohol, idiopathic) were also performed. We then evaluated the candidate gene Two loci in 12q24.11–12 and 20q12 showed significant association with ONFH. A stratified analysis suggested that the 12q24 locus was associated with ONFH through the drinking capacity. In the 20q12 locus, A novel ONFH locus was identified at chromosome 20q12, and
This study was conducted to investigate the influence of surgical experience on the outcomes and component positioning of total knee arthroplasty (TKA). We compared the outcomes and component positioning of simultaneous bilateral TKAs performed by supervisors and trainee surgeons. A total of 20 patients (40 knees) who underwent simultaneous bilateral primary TKA using the same cruciate-retaining TKA system between 2011 and 2015 were included. The mean patient age was 76 years (range: 64 to 86 years). There were 2 males and 18 females. The first phase of the operation was performed on the knee that was more severely degenerated by one supervisor who had performed over 1000 TKAs. The other knee was operated on next by trainee surgeons who had performed less than 20 TKAs. The knees were categorized into two groups: those operated on by supervisors (group S) and those operated on by trainee surgeons (group T). Outcome measures included range of motion (ROM), Knee Score (KS), and Function Score (FS). We also evaluated operative time, alignment of the leg, and the orientation of components, which was determined on post-operative long-leg coronal films.Aims
Patients and Methods
Dislocation is one of the most important complications in THA. Dual mobility cup (DMC) inserts reduce the risk for dislocation after total hip arthroplasty by increasing the oscillation angle. A lower rate of dislocation with use of a DMC insert has been reported in different studies. But there is no available research that clearly delineates the stability advantages of DMC inserts in primary THA. The aim of our study was to evaluate the area of the safe zone for a DMC insert, compared to a fixed insert for different anteversion angles of the femoral component. A model of the pelvis and femur were developed from computed tomography images. We defined the coordinate system of the pelvis relative to the anterior pelvic plane and the coordinate system of the femur relative to the posterior condylar plane. In our model, we simulated a positive anteversion position of the acetabular cup. The lower border for cup inclination is 50°. The safe zone was evaluated for the following range of motion of the implant: 120° of flexion, 90° of flexion 30° of internal rotation, 30° of extension, 40° of abduction, 40° of adduction, and 30° of external rotation. (Fig.1) The safe zone was calculated for both a fixed insert and a DMC insert over a pre-determined range of three-dimensional motion, and the effect of increasing the anteversion position of the femoral component from 5° to 35° quantified. The ratio of the safe zone for a DMC insert to a fixed insert was calculated.INTRODUCTION
Material and Methods
Compared with the cruciate-retaining (CR) insert for total knee arthroplasty (TKA), the cruciate-substituting (CS) insert has a raised anterior lip, providing greater anterior constraint, and thus, can be used in cases of posterior cruciate ligament (PCL) sacrifice. However, studies have shown that the PCL maintains femoral rollback during flexion, acts as a stabilizer against distal traction force and aids knee joint proprioception; therefore, the argument for PCL excision in CS TKA remains controversial. The purpose of this study was to analyze CS TKA kinematics and identify the role of the PCL. Seven fresh-frozen lower-extremity cadaver specimens were analyzed using Orthomap® Precision Knee Navigation software (Stryker Orthopaedics, Mahwah, NJ, USA). They were surgically implanted with Triathlon® components (Stryker Orthopaedics). The CS insert has a raised anterior lip, and the posterior geometry shares the same profile as the CR, so we can choose retaining or sacrificing the PCL. Six patterns were analyzed: (1) natural knee; (2) only anterior cruciate ligament excision; (3) CS TKA, PCL retention, and bony island preservation; (4) CS TKA, PCL retention, and bony island resection; (5) CS TKA and PCL excision; and (6) CR TKA and PCL excision. Center of the knee and center of the proximal tibia were registered using navigation system, and the magnitudes of the condylar translation were evaluated. And then, using trigonometric function, the magnitude of anterior-posterior translation of the femur was calculated.Introduction
Methods
Pelvic posterior tilt change (PPTC) after THA is caused by release of joint contracture and degenerative lumbar kyphosis. PPTC increases cup anteversion and inclination and results in a risk of prosthesis impingement (PI) and edge loading (EL). There was reportedly no component orientation of fixed bearing which can avoid PI and EL against 20°PPTC. However, dual mobility bearing (DM) has been reported to have a large oscillation angle and potential to withstand EL without increasing polyethylene (PE) wear against high cup inclination such as 60∼65°. The purpose of this study was to investigate the optimal orientation of DM-THA for avoiding PI and EL against postoperative 20°PPTC.Introduction
Objective
Computer navigation systems are quite sophisticated intra-operative support systems for the precise placement of acetabular or femoral components in THA. However, few studies have addressed the clinical benefits derived from using a navigation system to achieve precise placement of the implants. The purpose of this study is to investigate the early dislocation rate of navigation-assisted primary THA through a posterior approach in order to clarify the short-term benefit of using a computer navigation system. We retrospectively reviewed the early dislocation rate (within 12 months after surgery) of 475 consecutive primary cementless or hybrid THAs with femoral head sizes ≦32mm performed via posterior approach. There were 85 men and 390 women, with a mean age of 60 years (17 to 88) at operation. Preoperative diagnoses included osteoarthritis in 384 hips, osteonecrosis in 45 hips, and others in 46 hips (ex. RA, trauma, infection, congenital disease). All THAs were planned using a 3D templating system based on the combined anteversion theory, performed by single surgeon through a posterior approach with repair of the posterior capsule, assisted by a CT-based surface matching type computer navigation system for cup implantation. All patients were directly followed up at least 1 year after surgery. We classified all 475 joints into four groups: normal or mildly deformed hips (Group A; 308 joints, ex. primary OA, Crowe group 1, osteonecrosis), moderately deformed hips (Group B; 97 joints, ex. Crowe group 2, protrusio acetabuli, Perthes like deformity), severely deformed hips (Group C; 53 joints, ex. Crowe group 3 or 4, ankylosis, fused hip), and neuromuscular and cognitive disorders (Group D; 17 joints), and examined the dislocation rate for each group.Introduction
Methods
The number of total hip arthroplasties has been increasing worldwide, and it is expected that revision surgeries will increase significantly in the near future. Although reconstructing normal hip biomechanics with extensive bone loss in the revision surgery remains challenging. The custom−made acetabular component produced by additive manufacturing, which can be fitted to a patient's anatomy and bone defect, is expected to be a predominant reconstruction material. However, there have been few reports on the setting precision and molding precision of this type of material. The purpose of this study was to validate the custom−made acetabular component regarding postoperative three−dimensional positioning and alignment. Severe bone defects (Paprosky type 3A and 3B) were made in both four fresh cadaveric hip joints using an acetabular reamer mimicking clinical cases of acetabular component loosening or osteolysis in total hip arthroplasty. On the basis of computed tomography (CT) after making the bone defect, two types of custom−made acetabular components (augmented type and tri−flanged type) that adapted to the bone defect substantially were produced by an additive manufacturing machine. A confirmative CT scan was taken after implantation of the component, and then the data were installed in an analysis workstation to compare the postoperative component position and angle to those in the preoperative planning.Introduction
Methods
Many authors have described component position and leg length discrepancy (LLD) after total hip arthroplasty (THA) as the most important factors for good postoperative outcomes. However, regarding the relationships between component position and different approaches for THA, the optimal approach for component position and LLD remains unknown. The aims of this study were to compare these factors among the direct anterior, posterolateral, and direct lateral approaches on postoperative radiographs retrospectively, and determine which approach leads to good orientation in THA. We retrospectively evaluated 150 patients who underwent unilateral primary THA in our department between January 2009 and December 2014, with the direct anterior, posterolateral, or direct lateral approach used in 50 patients each. Patients with significant hip dysplasia (Crowe 3 or 4), advanced erosive arthritis, prevented osteotomy of the contralateral hip, and body mass index (BMI) of more than 30 were excluded. The mean age, sex, and preoperative diagnosis of the affected hip were equally distributed in patients who underwent THA with the different approaches. The mean BMI did not differ significantly among the groups. The radiographic measurements included cup inclination angle, dispersion of cup inclination from 40°, and LLD on an anteroposterior pelvic radiograph, and cup anteversion angle and dispersion of cup anteversion from 20° on a cross-table lateral radiograph postoperatively. We also measured the ratios of patients with both cup inclination of 30–50° and cup anteversion of 10–30° (target zone in our department), femoral stem varus/valgus, and LLD of 10 mm or less. Statistical analyses used an unpaired Introduction
Methods
We perform PAO via a modified Smith-Petersen approach. The purpose of this study was to investigate the result of PAO via a modified Smith-Petersen approach at a minimum 10-years' follow-up. We retrospectively reviewed 209 hips in 179 patients with acetabular dysplasia who underwent PAO with a modified Smith-Petersen approach from August 1995 to April 2010. Exclusion criteria were as follows: under 10 year follow-up, incomplete clinical or radiographic data. Harris hip score (HHS) was investigated preoperatively, at the time of most improvement and at the final follow-up for clinical evaluation. Tönnis classification was investigated preoperatively and at the final follow-up for evaluation of osteoarthritis. Center edge (CE) angle and acetabular roof obliquity (ARO) were investigated preoperatively, postoperatively and at the final-follow up for radiographic evaluation. Tönnis classification and radiographic parameters were investigated on anterior-posterior radiographs. Patients of conversion of PAO to total hip arthroplasty (THA) were investigated for preparing Kaplan Myer survival analysis. The Wilcoxon signed-rank test was used to compare changes in HHS and radiographic parameters between the preoperative and the postoperative values. Statistical significance was defined a priori as p < 0.05.Introduction
Methods
According to proposal of Noble, the femoral bone marrow cavity form of patients who underwent Total Hip Arthroplasty (THA) can be classified under 3 categories; those are Stovepipe, Normal and Champagne-fluted. We developed typical sodium chloride femoral model was created by 3D prototyping technique. The purpose was to identify the relationship of pressure zone of the surrounding areas between femoral bone marrow cavity form and hip stem. As opponent clarified stem design concept Zweymüller type model was used. According to CT data with the patients who underwent THA, the sodium chloride femoral model was custom-made and selected as the representative model based on Noble's 3 categories. Eight models of each category were used to performed mechanical test.Introduction
Materials and Method
On the basis of a proposal by Noble, the marrow cavity form can be classified into three categories: stovepipe, normal, and champagne-fluted. In the present study, three typical finite element femoral models were created using CT data based on Noble's three categories. The purpose was to identify the relationship of stress distribution of the surrounding areas between femoral bone marrow cavity form and hip stem. The results shed light on whether the distribution of the high-stress area reflects the stem design concept. In order to improve the results of THA, researchers need to consider the instability of a stem design based on the pressure zone and give feedback on future stem selection. To develop finite element models, two parts (cortical bone and stem) were constructed using four-node tetrahedral elements. The model consisted of about 40,000 elements. The material characteristics were defined by the combination of mass density, elastic coefficient, and Poisson's ratio. Concerning the analysis system, HP Z800 Workstation(HP, Japan) was used as hardware and LS-DYNA Ver. 971 (Livermore Software Technology Corporation, USA) as software. The distal end of the femur was constrained in all directions. On the basis of ISO 7206 Part 4,8 that specifies a method of endurance testing for joint prostheses, the stem was tilted 10°, and a 500 N resultant force in the area around the hip joint was applied to the head at an angle of 25° with the long axis. Automatic contact with a consideration of slip was used. Von Mises stress during a 1.0 s period after loading was analyzed, and stress distribution in the stem and its maximum value were calculated.Introduction
Methods
In performing posterior cruciate ligament- retaining total knee arthroplasty (CR-TKA), the original surgical instrument was devised to obtain the range of motion and stability of the knee joint adequate for daily life of Japanese people. We have presumed the tentative joint line as intercondylar notch point of the distal femur, and performed surgery using
There is a large gap between UKA and TKA in terms of tissue preservation including bone stock and knee ligament. We have recently introduced bicompartmental UKA (Bi-UKA) to fill the gap and achieve more “physiological” knee than TKA. In this study, we report the short-term results of Bi-UKA. Thirty knees in twenty-nine osteoarthritis patients who underwent Bi-UKA from December 2010 to December 2013 (6 males and 23 females, average age of 75) were clinically and radiologically evaluated with an average observation period of 19 months. The operative indications were (1)confirmed diagnosis of medial and lateral osteoarthritis or osteonecrosis with preserved status of patellofemoral joint; (2)range of knee flexion greater than 110°; (3)flexion contracture less than 20°; (4)clinically stable knee in the frontal and sagittal plane; (5)correctable knee deformity with fine knee congruency. In all cases, fixed type UKA was implanted through a tibia dependent cut using a spacer block. Zimmer Uni and TRIBRID UKA (Kyocera Medical Corporation) were implanted in 18 and 12 cases, respectively.Purpose
Subjects and Methods
The incidence of osteonecrosis was significantly lower in the anti-vasospasm agent group (32%) than that in the control group (75%). Vasospasm is one of the important factors involved in the pathogenesis of steroid-induced osteonecrosis. A number of studies have suggested that ischemia is the principal pathomechanism of osteonecrosis, however, the detailed mechanism responsible for ischemia remains unclear. It has recently been reported that the Rho/Rho-kinase mediated pathway (Rho-kinase pathway) is considered to be involved in the possible pathogenesis of various cardiovascular disorders as well as cerebral vasospasm. We examined the effects of fasudil (Rho-kinase inhibitor), an anti-vasospasm agent, on the development of steroid-induced osteonecrosis in rabbits.Summary Statement
Introduction
Fracture during total hip arthroplasty occurs partly because the acquisition of fixation at the time of stem implantation depends on the operator's experience and sensation due to the absence of definite criteria. Therefore, an objective evaluation method to determine whether the stem has been appropriately implanted is necessary. We clarified the relationship between the hammering sound frequency during stem implantation and internal stress in a femoral model, and evaluated the possible usefulness of hammering sound frequency analysis for preventing intraoperative fracture. Three types of cementless stem were used. Orthopedists performed stem insertion using a procedure similar to that employed in routine operation. Stress was estimated by finite element analysis using the hammering force calculated from the loading sensor as a loading condition, and frequency analysis of hammering sound data obtained using a microphone was performed (Fig. 1). Finite element analysis showed a decrease in the hammering sound frequency with an increase in the estimated maximum stress (Fig. 2, 3). When a decrease in frequency was observed, adequate hammering had already been performed to achieve press-fit stability. Therefore, there is a possibility that the continuation of hammering induces intraoperative fractures that become a problem. Based on the relationship between stress and frequency, the evaluation of changes in frequency may be useful for preventing the development of intraoperative fractures. When a decrease in frequency is observed, the hammering force should be reduced thereafter. Hammering sound frequency analysis may allow the prediction of bone fractures that can be visually confirmed, and may be a useful objective evaluation method for the prevention of intraoperative bone fracture.
