Today the use of pneumatic tourniquet is commonly accepted in total knee arthroplasty (TKA) to reduce perioperative blood loss. There are a few prospective randomised and nonrandomised studies that compare the effect of tourniquet release timing in cementless or cemented unilateral TKA. However, many of these studies show an inadequate reporting and methodology. This randomized prospective study was designed to investigate the efficiency of tourniquet release timing in preventing perioperative blood loss in a simultaneous bilateral TKA study design. To our knowledge, this is the first study of its kind, in which the effect of tourniquet release timing on perioperative blood loss was investigated in simultaneous bilateral cemented TKA.

In 20 patients (40 knees) one knee was operated with tourniquet release and hemostasis before wound closure, and the other knee with tourniquet release after wound closure and pressure dressing. To determine the order of tourniquet release technique for simultaneous bilateral TKA, patients were randomized in two groups: ‘Group A’ first knee with tourniquet release and hemostasis before wound closure, and ‘Group B’ second knee with tourniquet release and hemostasis before wound closure. The blood loss was recorded 48 hours postoperative for each technique.

We found no significant difference in total blood loss between both techniques (p =.930), but a significant difference in operating time (p =.035). There were no postoperative complications at a follow-up of 6 month. Other studies report an increase the blood loss in early tourniquet release and an increase the risk of early postoperative complications in deflation of tourniquet after wound closure. In this study we found no significant difference in perioperative blood loss and no increase of postoperative complications. Therefore, we recommend a tourniquet release after wound closure to reduce the duration of TKA procedure and to avoid possible risks of extended anaesthesia.

Introduction: Besides other techniques to reduce blood loss, the use of pneumatic tourniquet is commonly accepted in total knee arthroplasty (TKA). Furthermore it is used to maintain a clean and dry operative field to improve visualization, to use a better cementing technique, and to reduce operating time. The time of tourniquet release is discussed controversially in literature. However, there are only a few prospective randomised studies that compared the effect of timing of tourniquet release in cementless or cemented TKA. To our knowledge, this is the first study that investigated the influence of tourniquet release on blood loss in a randomized prospective study in simultaneous bilateral cemented TKA.

Methods: 20 patients (40 knees) underwent simultaneous bilateral cemented TKA with the cemented Triathlon Knee System (Stryker) between February and May 2006. The mean age of the patients was 67 years (67+/−11 years). 7 males and 13 females were treated with TKA (mean tourniquet pressure: 282.5+/−33.5 mm Hg). In 20 patients one knee was operated with tourniquet release and hemostasis before wound closure (“Technique A”), and the other knee with tourniquet release after wound closure and pressure dressing (“Technique B”). To determine the order of tourniquet release technique in simultaneous bilateral TKA, the patients were randomized in two groups: “Group A” (20 knees) first knee with tourniquet release and hemostasis before wound closure, and “Group B” (20 knees) second knee with tourniquet release and hemostasis before wound closure. The patients were given low molecular weight heparin and a leg dressing to prevent deep vein thrombosis. The blood loss was monitored two days after surgery till removal of the wound drains.

Results: We found no significant difference in total blood loss between “Technique A” (753+/−390 ml) and “Technique B” (760+/−343 ml) (p=.930). Furthermore there was no significant difference in total blood loss between both techniques after randomizing in “Group A” (“Technique A” 653+/−398 ml; “Technique B” 686+/−267 ml; p=.751) and “Group B” (“Technique A” 854+/−374 ml; “Technique B” 834+/−406 ml; p=.861). However, the operating time showed a significant difference between “Technique A” (58+/−18 minutes) and “Technique B” (51+/−17 minutes) (p=.035).

Discussion: In this study we compared the effect of timing of tourniquet release on perioperative blood loss in a randomized prospective study in simultaneous bilateral cemented TKA. Our results showed no significant difference of blood loss but a significant difference of operation time. Therefore, we recommend a tourniquet release after wound closure to reduce operating time and to minimize the risk of peri- and postoperative complications at approximately similarly blood loss between both techniques.

INTRODUCTION: The techniques to stabilize the patella can be divided into two groups: the first group seeks to change the direction of the extensor mechanism in order to medialize the extending force vector of the quadriceps muscle, e.g. by a distal medialization of the tibial tuberosity or a proximal realignment; the second seeks to reconstruct the medial patellofemoral ligament (MPFL). The goal of this study was therefore to measure changes in patellofemoral kinematics in the intact, MPFL deficient knee, after medial transfer of the tibial tuberosity, after proximal realignment as well as after reconstruction of the MPFL.

METHODS: Eight fresh frozen right knee specimens were mounted in a knee simulator in which isokinetic flexion-extension motions were simulated. Extension cycles were simulated from 120° flexion to full knee extension with an extension moment of 31 Nm. Movement of the patella relative to the femur was measured using an ultrasound based 3D motion analysis system (Zebris, Isny, Germany). During the first test cycles, patellar movement under intact knee conditions were measured, while a constant 100 N laterally oriented force was applied by means of a steel cable attached to the patella. Subsequently, patellar movement was again measured after: transecting the MPL (deficient knee), performing a medialization of the tibial tuberosity, after reconstruction of the transected MPL using a semitendinosus autograft and after proximal realignment.

RESULTS: The patella of the intact knee moved along a medial path with a maximum attained position of 8.8 mm at 25° of knee flexion. The patella of the deficient knee moved up to 4.6 mm (p=0.04) in the medial direction at maximal extension at 30° of knee flexion. After medial transfer of the tibial tuberosity patellar movement reached a maximum medial position of 12.8 mm (p=0.04) at 22° of knee flexion with the laterally oriented force. With a reconstructed MPL, the patella attained a maximum medial position 14.8 mm (p=0.04) at 24.0° of knee flexion. Following proximal realignment, the patella moved on a medial, but significant (p=0.03) different path up to 13.8 mm medially at 30° of knee flexion. In addition, following medialization of the tibial tuberosity and proximal realignment, the center of the patella was significantly (p=0.03) more internally rotated (tilted) than the physiologic patella.

DISCUSSION: The shape of the movement curves after the stabilizating procedures resulted in a medialization relative to intact and deficient conditions. With the reconstructed medial patellofemoral ligament, the patella moved along the most medially oriented path with physiologic tilting. The results suggest that a semi-tendinous autograft can provide sufficient stabilization to prevent lateral displacement or subluxation with physiologic patellar tilt.

Introduction High precision of axis alignement in Total Knee Arthroplasty by usage of navigation tools is a known fact. However, a common disadvantage of navigation tools is the additional time needed for calibration. Especially in time/cost-sensitive hospital environments this can lead to a neglection of navigation tools usage. In this study we address work-economics during navigation assisted total knee arthroplasty. Specifically, we introduce the concept of a well-trained navigator assistant who performs navigation related work steps during surgery while the primary surgeon concentrates on the remaining work-steps.

In a prospective study of primary TKA we compared environmental parameters of surgeries performed with and without the Navigator Concept.

Materials and Methods 60 Total Knee Arthroplasties were performed using an active navigation system (Stryker Navigation System) (40) or a conventional internal/external alignement jig for implantation of the Interax Knee endoprostheses. Half of the navigated knee arthroplasties were performed using a conventional set-up with a primary surgeon and two assistants serving the navigation system and performing the relevant surgical steps. The other half was done by surgeon teams of a primary surgeon, a navigator assistant and a second assistant. The surgical steps were broken down to a complex work-sharing system. The teams were intensively trained in their work-share by simulating an artificial TKA in a specially designed TKA-Navigation lab. During surgery, the timing of individual steps was recorded. Pre- and postoperative x-rays of the limbs were taken and digitized to an computerized axis-measurement system. Data of both groups were compared using ANOVA and Tuckey post-hoc tests.

Results Results showed a significant difference in surgery time between the three groups (p=0,01) with equivalent surgery times of the conventional and navigator concept group, while the remaining navigated group showed longer surgery times. Axis alignments were statistically not influenced, however demonstrated a tendency to higher precision in the navigator concept group.

Discussion This study is the first to address work-economics in navigated TKA. With the introduction of a specifically trained navigator assistant, a precise work-sharing plan and an intensive training lab, high precision in TKA can be achieved by navigation usage even in a highly cost-sensitive environment. The basis for success, however, is support and investment in training of team surgeons. This concept may provide the basis for other musculoskeletal surgeries demanding both high-tech for precision and time-effectiveness for cost reduction.

Introduction: This biomechanical study evaluates the consequences of a mid-third BPTB-autograft excision on patellofemoral biomechanics and knee kinematics. Of particular interest was the potential role of a BPTB-autograft excision on postoperative anterior knee pain in ACL replacement surgery.

Methods: Isokinetic knee extension from 120 of flexion to full extension was simulated on 9 human knee cadaver specimens (5 male, 4 female, average age at death 43 years). Joint kinematics was evaluated by ultrasound sensors (CMS 100TM, Zebris, Isny, Germany), and retro-patellar contact pressure was measured using a thin-film resistive ink pressure system (K-ScanTM 4000, Tekscan, Boston). All data were taken before and after excision of a mid-third BPTB-autograft.

Results: Following excision of a mid-third patella tendon autograft we found a significant (p< 0.05) proximalization of the patella (average: 0.5 mm) and a significant decrease of patella flexion in the sagittal plane (average: 1). Patella tilt, -rotation (frontal plane), -translation (medial/lateral) and tibiarotation (external-/internal), -axis (varus-/valgus position) remained unchanged. Patellofemoral contact pressure and -area decreased significantly near knee extension (p< 0.05).

Conclusions: We conclude that an excision of a mid-third patella tendon autograft results in a lengthening of the tendon with a proximalization of the patella. As the patellofemoral pressure decreases and the patella remains centralized, postoperative anterior knee pain following ACL-replacement using a BPTB autograft can not be explained by the results of our study.

Objective: To determine the effect of intraoperative pre-tensioning of meniscal transplants on the tibial plateau in an animal experiment:

Material and Methods: Thirty-six sheep were used for this animal study. The animals were divided into 6 groups: -group A was the sham group; – in group B medial meniscectomy was performed; in group C-F medial meniscus transplantation with an autograft was carried out. In group C-F different defined pre-tensioning was applied to meniscal transplants via bone tunnel sutures (0N, 20N, 40N and 60N respectively). After 6 months the animals were sacrificed. The lower limb specimen were placed in a material testing machine under standard conditions in 30, 60 and 90 degrees of flexion and loaded through the femoral axis to 500N. For determining contact area a thin film pressure transducer (Tekscan) was positioned underneath the medial meniscus. Statistical analysis was performed using Mann-Whitney test.

Results: The mean contact pressure of the sham group and the groups with the transplanted meniscus was significantly lower in relation to meniscectomized knees. Significant increases in contact area and reductions in in peak contact pressure could be identified. At greater flexion angles only the meniscal transplantation group with the 40N pretension showed a significant increase of contact area and/or very strong trend in relation to meniscectomized knees. Concerning peak contact pressure, all meniscal transplantated groups with exception th 0N pre-tension group showed significant reduction in comparison to the meniscectomized group.

Conclusion: Regarding the results we can conclude that the biological ingrowth has an influence on the biomechanical effect of meniscal transplantation. For this animal model and with the compressive load of 500N especially 40N pre-tension of meniscal transplants seems to be efficient to provide load transmission function of the meniscus.

Introduction: Periprosthetic fractures occurring during implantation of non-cemented Total Hip Arthroplasty (THA) are considered major surgical complications. As a shot-term disadvantage, patients are required to partially weight-bear. Additionally, high risks of stem migration and joint luxation can be assumed. On the other hand, in fear of fracture surgeons may undersize stems and subsequently trigger failure rates in THA.

As the long-term consequences of Vancouver A and B1 fractures are not fully known, the goal of this study now was to analyze the postoperative performance of non-cemented THA with respect to perioperative fractures.

Materials and Methods: Between 1997 and 2003 41 peri-operative hip fractures were monitored in 1216 primary Total Hip Arthroplasties using the non-cemented Bicon-tact THA stem. Pre-OP and after a follow-up period of 2,2 (+−3,1) years patients were examined clinically and radiographically. Investigation parameters were Harris-Hip-Scores, SF-36 scores, function score, hospitalization, implant survival /revisions and radiographic parameters (stem migration, trochanter migration, osteolysis, bone union, callus formation and bone quality). Fractures were graded using the Vancouver and Mont+Maar classifications. Patients were compared to a comparable collective of THA patients without perioperative fractures. Pooled data of both groups were compared using non-parametric Kruskal-Wallis tests.

Results: Results showed a significant increase in Harris-Hip scores for all THA of 36 (+−17,7) points. There were no differences in function scores (2,3; score 1–6), postoperative pain (4,8; score 1–10), and time of hospitali-sation (21,3d; +−3,7 range, 14 – 32). The non-union rate was 13%, with 85% of trochanteric fractures showing migration. 47% of the Patients in the fracture group were instructed to maintain restricted weight bearing for 6 weeks. No Trendelenburg signs were observed in the fracture group. Stem migration of mean 0,6 cm (+−0,4) was observed in 13% of Vancouver A and B1 patients (6,4% of A, 20,1% of B1). Long-term cerclage wire failure was observed in 20%. Joint luxation was observed in 1 patient. No hips were revised during the follow-up period.

Discussion: Follow-ups of perioperative fractures classes Vancouver A and B1 during non-cemented THA using the Bicontact stem show associations with stem migration, long-term stabilization implant failure and non-union. However, none of these observations seem to be influencing the overall THA performance and patient satisfaction. Specifically, complications commonly associated with perioperative primary prosthetic fractures as luxation and limping were not signifi-cant. At a short-term perspective, perioperative THA fractures prohibit early weight-bearing. However at a mid to long-term perspective, no disadvantages were apparent in comparison to primary THA without fracture complications.

Purpose: The study was designed to evaluate the biomechanical and neurohistological properties of the infrapatellar fat especially concerning its potential role in the anterior knee pain syndrome.

Methods: Isokinetic knee extension from 120 of flexion to full extension was simulated on 10 human knee cadaver specimens (6 male, 4 female, average age at death 44 years). Joint kinematics was evaluated by ultrasound sensors (CMS 100TM, Zebris, Isny, Germany), and retro-patellar contact pressure was measured using a thin-film resistive ink pressure system (K-ScanTM 4000, Tekscan, Boston). The infrapatellar tissue pressure was analyzed using a closed sensor cell. The patellar contact pressure was measured before and after resection of the infrapatellar fat pad. The distribution of nerve fibres in the infrapatellar fat pad was assed immunohistologically in a second part of the study.

Results: Infrapatellar tissue pressure significantly increased during knee extension < 20 and flexion > 100 ranging from 343 (223) mbar at O- to 60 (64) mbar at 60 of flexion. Total resection of the infrapatellar fat pad resulted in a significant decrease in tibial external rotation of 3° in full knee extension (p=0.011), combined with a significant medial translation of the patella between 29 and 69° knee flexion (p=0.017 to 0.028). Retropatellar contact pressure was significantly (p< 0.05) reduced at all flexion angles, at 120° knee flexion more than in full knee extension. Studying all the detectable nerves present in 50 fields (x200 objective) we found an average of 6.4 substance-P- (25%) of a total of 24.7 nerve fibres in the infrapatellar fat pad. There was a significantly (p< 0.01) higher number of substance-P-fibers (24.4 (28%) of 105.7) in the superficial synovial tissue. The number of S-100-fibers was significantly (p< 0.05) higher in the central and lateral part of the fat pad.

Conclusions: Based on these results, we conclude that resection of the infrapatellar fat pad could potentially reduce clinical symptoms in the anterior knee pain syndrome, and that, contrary to commonly believed, the infrapatellar fat pad may have a biomechanical function and play a role in the anterior knee pain syndrome.

Aims: The purpose of the study was to determine the distribution and speciþcation of nerve þbers in the infrapatellar fat pad especially concerning nociceptive substance-P þbres. Methods: The infrapatellar fat pad was taken as a fresh specimen out of 21 patients (4 male, 17 female, mean age 69 years) during total knee arthroplasty. It was dissected in þve deþned parts, þxed and embedded in parafþn. Immunohistochemical techniques using antibodies against S-100 protein and substance-P were employed to determine and specify the nerve þbres. Results: Studying all the detectable nerves present in 50 þelds (x200 objective) we found an average of 6,4 substance-P- (25%) of a total of 24,7 nerve þbres in the infrapatellar fat pad. There was a significantly (p< 0,01) higher number of substance-P-þbers (24,4 (28%) of 105,7) in the surfacing synovial tissue. The number of S-100-þbers was signiþcantly (p< 0,05) higher in the central and lateral part of the fat pad. Conclusions: The occurance and distribution of nerve þbres in the infrapatellar fat pad suggests a nociceptive function. A neurohistological role in the anterior knee pain syndrome is assumed.

Aims: This biomechanical study was performed to evaluate the consequences of a total infrapatellar fat pad resection on knee kinematics and patellar contact pressure. Methods: Knee motion between 120∞ of flexion and full extension was performed in a knee kinemator on 10 fresh frozen knee specimens (6 male, 4 female, average age 44 years). The joint kinematics was evaluated by ultrasound sensors (Zebris-system), the patellar contact pressure was measured using a thin-film resistive ink pressure system (Tekscan). All data were taken before and after resection of the infrapatellar fat pad and statistically analyzed. Results: A total resection of the infrapatellar fat pad resulted in a significant (p< 0,05) decrease of the tibial external rotation in knee extension combined with a significant (p< 0,05) medial translation of the patella. The patellar contact pressure was significantly (p< 0,05) reduced, in knee flexion more than in knee extension. Conclusions: We conclude that a resection of the infrapatellar fat pad might reduce clinical symptoms in the anterior knee pain syndrome. A biomechanical function of the infrapatellar fat is suspected.

In 20 skeletally mature female merino sheep, divided into four groups, we performed total medial meniscectomy, removal of the middle third of the patellar tendon, and tenotomy of the calcaneal tendon of the right hind leg. Group I (control) had no additional procedures. In the other three groups the medial meniscus was replaced by the middle third of the patellar tendon from the ipsilateral knee. The animals were killed at three (group II), six (group III), or 12 months (group IV) and the tendon-meniscus examined macroscopically, by light and scanning electron microscopy, and biomechanically. Remodelling of the tissue had taken place by 12 months but the failure stress and tensile modulus for the tendon-meniscus were lower than for the normal meniscus. Our evidence suggests that, in sheep, replacement of a meniscus by a tendon autograft may decrease the severity of the degenerative changes that occur after meniscectomy.