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Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 303 - 303
1 Mar 2013
Gallagher J Pelletier M Bertollo N Walsh W
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Introduction

Loading of the implant/cement bond during polymerization is possible when a joint is put through passive range of motion shortly after implantation. This may adversely affect the integrity of the cement – implant interface. The aim of this study was to evaluate the effect of implant motion during cement polymerization on the mechanical properties of the cement – implant interface.

Methods

Simulated titanium tibial trays (15 mm dial tray, 15 mm keel) were used in this study and implanted in cellular rigid polyurethane foam (12.5 pcf) (Sawbones Vashon, WA, USA). Surface roughness (Ra) of implants was verified as 3.60μm with a 2μm tip at 0.5 mm/s over a length of 1.6 mm (SurfAnalyzer, MAHR Federal Inc., Providence, RI, USA). Palacos cement (Heraeus Medical, Wehrheim, Germany) was mixed for 2 minutes followed by implantation and one of 3 motion regimes at two time points. Six groups were tested. Motion was applied at three minutes for three groups. This motion was 1)axial micromotion for 20 cycles at 100 microns and 0.5 Hz, 2)rotational of 20 cycles at +/− 1.5 degrees and 0.5 Hz, or 3)both motions sumultaneously. An additional three groups were tested at 6 minutes under the same conditions. Motion was applied using calibrated mechanical testing equipment (MTS systems, Eden Prarie, MN, USA).

Implants were tested in tension to failure at 0.5 mm/min, 24 hrs after implantation. The peak load, stiffness and energy were determined for each sample. Data was analysed using an Analysis of Variance and a Games Howell post hoc tests where appropriate.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 47 - 47
1 Mar 2009
van Duren B Pandit H Gallagher J Beard D Dodd C Gill H Murray D
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Introduction: Treatment options for the young active patient with isolated symptomatic medial compartment osteoarthritis and pre-existing anterior cruciate ligament (ACL) deficiency are limited. Implant longevity and activity levels may preclude total knee arthroplasty (TKA), whilst high tibial osteotomy HTO and unicompartmental arthroplasty (UKA) are unreliable due to ligamentous instability. UKA’s tend to fail because of wear or tibial loosening resulting from eccentric loading. Combined UKA and ACL reconstruction may therefore be a solution.

Method: Fifteen patients with combined ACL reconstruction and Oxford UKA (ACLR group), were matched (age, gender and follow-up period) with 15 patients with Oxford UKA with intact ACL (ACLI group). Prospectively collected clinical and x-ray data from the last follow-up (minimum 3 years, range: 3–5) were compared. Ten patients from each group also underwent in-vivo kinematic assessment using a standardised protocol.

Results: At the last follow-up, the clinical outcome for the two groups were similar (ACLR: OKS 46, KSS (objective): 99, ACLI: OKS 43, KSS (objective): 94). One ACLR patient needed revision due to infection. Radiological assessment did not show any significant difference between relative component positions and none of the patients had pathological radiolucencies suggestive of component loosening. Kinematic assessment showed posterior placement of the femur on tibia in extension for the ACLR group, which corrected with further flexion.

Conclusions: The short-term clinical results of combined ACL reconstruction and UKA are excellent. Lack of pathological radiolucencies and near normal knee kinematics suggest that early tibial loosening due to eccentric loading is unlikely. Similarly, wear is unlikely to be a problem because of the wear resistance of mobile bearing devices.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 47 - 48
1 Mar 2009
van Duren B Gallagher J Pandit H Beard D Dodd C Gill H Murray D
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Introduction: The Oxford unicompartmental knee replacement (UKR) use in the lateral compartment has been associated with a reduced flexion range and increased medial compartment pain than seen with its medial counterpart due to, in part, the inadequacy of a flat tibial tray replacing the domed anatomy of the lateral tibia. A new design incorporating a domed tibial component and a biconcave meniscal bearing has been developed to overcome these problems.

This study reports a clinical comparison of new and old establishing whether this modified implant has maintained the established normal kinematic profile of the Oxford UKR.

Method: Patients undergoing lateral UKR for OA were recruited for the study. Fifty one patients who underwent UKR with the domed design were compared to 60 patients who had lateral UKR with a flat inferior bearing surface. Kinematic evaluation was performed on 3 equal subgroups (n = 20); Group 1-Normal volunteer knees, Group 2-Flat Oxford Lateral UKR’s and Group 3-Domed Oxford Lateral UKR’s. The sagittal plane kinematics of each knee was assessed using videofluoroscopic analysis whilst performing a step up and deep knee bend activity. The fluoroscopic images were recorded digitally, corrected for distortion using a global correction method and analysed using specially developed software to identify the anatomical landmarks needed to determine the Patella Tendon Angle (PTA) (the angle the patella tendon and the tibial axis).

Knee kinematics were assessed by analysing the movement of the femur relative to the tibia using the PTA.

Results: PTA/KFA values, for both devices, from extension to flexion did not show any significant difference in PTA values in comparison to the normals as measured by a 3-way ANOVA. The Domed implant achieved higher maximal active flexion during the lunge exercise than those with a flat implant. Only 33% of the flat UKR’s achieved KFA of 130° or more under load whilst performing a lunge, compared with 75% of domed UKR’s and 90% of normal knees. No flat UKR achieved a KFA of 140° or more, yet 50% of all domed UKR’s did, as did 60% of all normal knees.

Conclusions: There was no significant difference in sagittal plane kinematics of the domed and flat Oxford UKR’s. Both designs had favorable kinematic profiles closely resembling that of the normal knee, suggesting normal function of the cruciate mechanism. The domed knees had a greater range of motion under load compared to the flats, approaching levels seen with the normal knee, suggesting that limited flexion for the flat plateau results from over tightening in high flexion and that this is corrected with the domed plateau. Problems with the second generation of lateral Oxford UKA have been rectified by a new bi-concave bearing without losing bearing stability and normal kinematics.


The Journal of Bone & Joint Surgery British Volume
Vol. 91-B, Issue 2 | Pages 185 - 189
1 Feb 2009
Pandit H Jenkins C Beard DJ Gallagher J Price AJ Dodd CAF Goodfellow JW Murray DW

We randomised 62 knees to receive either cemented or cementless versions of the Oxford unicompartmental knee replacement. The implants used in both arms of the study were similar, except that the cementless components were coated with porous titanium and hydroxyapatite. The tibial interfaces were studied with fluoroscopically-aligned radiographs.

At one year there was no difference in clinical outcome between the two groups. Narrow radiolucent lines were seen at the bone-implant interfaces in 75% of cemented tibial components. These were partial in 43%, and complete in 32%. In the cementless implants, partial radiolucencies were seen in 7% and complete radiolucencies in none. These differences are statistically significant (p < 0.0001) and imply satisfactory bone ingrowth into the cementless implants.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 384 - 384
1 Jul 2008
Gallagher J Van Duren B Pandit H Beard D Gill H Dodd C Murray D
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Background: The Oxford unicompartmental knee replacement (UKR) use in the lateral compartment has been associated with a reduced flexion range, increased medial compartment pain and a higher dislocation rate than seen with its medial counterpart due to the inadequacy of a flat tibial tray replacing the domed anatomy of the lateral tibia. A new design incorporating a domed tibial component and a biconcave meniscal bearing has been developed to overcome these problems. This current study was designed to establish whether this modi-fied ‘domed’ implant has maintained the established normal kinematic profile of the Oxford UKR.

Methods: The study population consisted of 60 participants from three equal groups; Group 1- Normal volunteer knees (n = 20), Group 2 – Flat Oxford Lateral UKR’s (n = 20) and Group 3 – Domed Oxford Lateral UKR’s (n = 20). The sagittal plane kinematics of each involved knee was assessed continuously using videofluoroscopic analysis. A standardised protocol of step-up and deep lunge was used to assess loadbearing range of motion during which the patella tendon angle (PTA) was measured as a function of the knee flexion angle (KFA).

Results: PTA/KFA values compared at 10 degree KFA increments from maximal extension to maximal flexion for all 3 groups did not demonstrate any statistically significant difference in PTA values between any group as measured by a 3-way ANOVA. The Domed implant achieved higher maximal active flexion during the lunge exercise than those with a Flat implant. Only 33% of the Flat UKR’s achieved KFA of 130 degrees or more under load whilst performing a lunge, compared with 75% of domed UKR’s and 90% of normal knees. No Flat UKR achieved a KFA of 140 degrees or more, yet 50% of all domed UKR’s did, as also did 60% of all normal knees.

Conclusions: There is no significant difference in the sagittal plane kinematics of the domed and flat Oxford UKR’s. Both implant designs have a favourable kinematic profile closely resembling the normal knee. The domed knees though do have a greater range of motion under load as compared to the flats, approaching levels seen with the normal knee.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 379 - 379
1 Jul 2008
Van B Pandit H Gallagher J Gill H Zavatsky A Shakespeare D Murray D
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Introduction: Restoration of predictable and normal knee kinematics after a TKR can improve the patient’s function. Traditional designs exhibit grossly abnormal kinematics with the femur subluxing posteriorly in extension and a paradoxical forward slide in flexion. In addition, the kinematics are very variable. Newer designs were intended to overcome these problems, owing to their ability to provide ‘guided motion’ of the components. The medial pivot knee uses a specifically designed articulating surface constraining the femoral component to externally rotate about an axis through the medial compartment.

This study assesses the functional in vivo kinematics of Advanced Medial Pivot (AMP) TKR and compares it to kinematics of the normal knee.

Methods: Thirteen patients with pre-operative diagnosis of primary osteoarthritis, who had undergone a knee replacement with the AMP knee at least one-year prior were recruited in this study. All had an excellent clinical outcome (as assessed by AKSS) and underwent fluoro-scopic analysis whilst performing a step up activity. Knee kinematics were assessed by analysing the movement of the femur relative to the tibia using the Patella Tendon Angle (PTA) through the range of knee flexion. This data was compared to that of thirteen normal knees.

Results: The PTA for the normal knee has a linear relationship with knee flexion. The PTA is 14 degrees in full extension and decreases to -10 degrees at 100 degrees knee flexion during a step-up exercise. Between extension and 60 degrees of knee flexion, no significant difference was found between the PTA for the normal knee and for the AMP. The PTA for AMP is significantly higher for values of knee flexion exceeding 60 degrees. The standard deviation for different values of knee flex-ion is similar to that seen in the normal knee.

Conclusions: In extension, the PTA is near normal but in flexion PTA is higher than normal suggesting that the femur is too anterior. The variability of the kinematics for AMP TKR is similar to that of the normal knee and is better than that of most other knee designs that we have studied in the past, indicating that it is a stable TKR.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 388 - 388
1 Jul 2008
Van B Pandit H Gallagher J Gill H Zavatsky A Thomas N Murray D
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Introduction: The cam-post mechanism of Posterior Stabilized Total Knee Arthroplasty (PS-TKA) should provide a constraint that limits anterior translation of the femur on the tibia in flexion and thereby ensure femoral roll-back with progressive knee flexion. In a previous fluoroscopic study we showed that the sagittal plane kinematics of a PCL substituting TKA (Scorpio PS) was abnormal in flexion, suggesting inefficiency of the cam-post mechanism. We also assessed the movement of the femur relative to the tibia using the Patella Tendon Angle (PTA) through the range of knee flexion (0 to 90 degrees). The aim of the current study was to investigate in greater detail why the cam-post mechanism was ineffective by assessing the contact point movement and the distance between the cam and post.

Method: Twelve patients with Scorpio PS TKA underwent fluoroscopic assessment of the knee during a step up exercise and a weight bearing deep knee bend. The image distortion was corrected using a global correction method and the data was analysed using a 3D model fitting technique. Having determined the component position, the minimum distance between cam and post were determined. The femoro-tibial contact positions of the medial and lateral condyles were determined relative to the mid-coronal plane of the tibial component. The PTA was calculated by measuring the angle subtended by patella tendon with the tibial axis and was plotted against knee flexion angle (KFA).

Results: The relationship between PTA and KFA was abnormal relative to the normal knee. Between extension and 60 degrees flexion there was forward movement of both medial (11 mm) and lateral (5 mm) femoral condyles. Thereafter, both condyles moved back (10 mm). The cam-post mechanism failed to engage in one case while in others it engaged between 70 to 100 degrees.

Conclusions: The 3D analysis has confirmed the preliminary findings of the previous study using the PTA and KFA relationship. Despite the cam engaging in flexion normal knee kinematics were not restored. The femoral roll-back is inadequate and starts to occur at least 20 degrees before the cam and post engage.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 369 - 369
1 Jul 2008
Gallagher J Lee C Schablowski M Aldinger P Gill H Murray D
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Background: The Oxford unicompartmental knee replacement (UKR) use in the lateral compartment has been associated with a reduced flexion range and diminished femoral rollback. It is postulated that this may be due to a flat tibial tray replacing the domed anatomy of the lateral tibia, tightening the posterolateral flex-ion gap. A new design incorporating a domed tibial component and a biconcave meniscal bearing has been developed to increase; (i) the posterolateral flexion gap in deep knee flexion (ii) meniscal bearing movement and (iii) lateral femoral condyle (LFC) rollback. A cadaveric study was designed to test these three outcomes.

Methods: The sagittal plane kinematics of seven thawed fresh frozen cadaver specimens within an upright Oxford testing rig were assessed under three different conditions; (i) intact normal cadaver knee (ii) flat lateral Oxford UKR (iii) domed lateral Oxford UKR. Each condition was tested during three ranges of motion (ROM) and data recorded during a flexion or extension half cycle. Knee flexion angle (KFA) and displacement measures of the lateral collateral ligament (LCL), LFC rollback and anteroposterior meniscal bearing movement were performed throughout knee ROM using four [3 linear, 1 rotary] potentiometer devices. Potentiometer data was recorded as a voltage reading and subsequently converted to either a millimetre displacement or degree measure using a calibration formula. All data points were compared at 10 degree interpolations of KFA.

Results: The flexion half cycles demonstrated the flat Oxford lateral UKR achieved 80.7% of normal cadaveric LFC rollback. The domed Oxford lateral UKR achieved 108.8% of normal cadaveric LFC rollback. The ratio of LFC rollback in the domed to flat UKR’s was 1.35 times (134.9%). Meniscal bearing movement in flexion demonstrated a domed to flat UKR ratio of 1.3 times (129.7%). Similar values were obtained for extension half cycles in favour of the domed Oxford lateral UKR. No significant differences were identified in LCL measures.

Conclusions: The domed Oxford lateral UKR implant allows for improved bearing movement and femoral rollback when compared to the flat Oxford lateral UKR. The sagittal plane kinematics of the domed Oxford lateral UKR as represented by femoral rollback values approximate those of the normal cadaver knee.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages - 12
1 Mar 2002
Gallagher J Tierney P Murray P O’Brien M
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Introduction: The infrapatellar fat pad was first described in 1904 by Albert Hoffa. Sometimes disregarded, it is apparent that the infrapatellar fat pad is of importance to knee joint function as fat at this site is only lost in severely emaciated individuals. Also, recent MRI studies have described various pathological changes affecting the fat pad. This study examined the anatomy of the infrapatellar fat pad in relation to knee symptoms and surgical approaches.

Materials and Methods: 8 preserved knees were dissected via semicircular parapatellar incisions extending from the tibial tubercle to the superior patellar border and including the quadriceps muscle 13 cm above the superior border of the patella. The synovial membrane of the joint and the ligamentum mucosum were divided and the tibial tubercle was then excised. The resultant tissue complex was removed and the fat pad dissected away from surrounding structures. The appearance, volume and presence of any clefts in the pad were recorded. The cadaveric dissections were then compared to direct observation of the fat pad during total knee replacement, during arthroscopy and on MR imaging.

Results: The infrapatellar fat pad was found to be present in all cases. It had a consistent shape consisting of a central mass with medial and lateral extensions. The ligamentum mucosum was attached to the intercondylar notch of the femur in all cases and measured an average of 15.7mm at its base. A horizontal cleft was found in 6 cases and a vertical cleft was found in 7 cases. Both have been previously noted. A tag extended superiorly from the posterior aspect of the fat pad in 7 cases. The volume of the fat pad had quite a large range among individual cadavers (average volume was 24 ml, range: 12–36ml). The intra-individual variation was smaller with an average difference of 4ml (range:2.7ml) between knees.

Discussion: The infrapatellar fat pad has been implicated in a wide variety of conditions affecting the knee joint. It has been shown to be involved in arthofibrosis of the knee following surgery, patellar tendonitis, formation of intra-articular fibrous bands, and a site of an ossifying chondroma. It seems that fat pad pathology is usually secondary to other knee joint pathology and primary involvement is rare. The presence of clefts in the fat pad is of importance as a distended cleft may mimic an abnormality and an abnormality in the cleft may be overlooked on imaging of the knee joint. The appearance of the fat pad on direct visualisation in the living person presented a fat pad with a more globular appearance than that seen in the cadaver. The clefts were clearly visualised on MRI.

Conclusion: The infrapatellar fat pad is a structure that is consistently present in the knee joint. It consists of a central body with medial and lateral and medical extensions. It usually contains a vertical cleft located superiorly and a horizontal cleft located inferiorly as well as a tag of fat extending superiorly, which forms the roof of the vertical cleft. The infrapatellar fat pad is attached to the intercondylar notch of the femur by the ligamentum mucosum and is firmly anchored to the patella by dense fibrous tissue.