The treatment of paediatric supracondylar humeral fractures is likely one of the first procedures involving X-ray guided wire insertion that trainee orthopaedic surgeons will encounter. Pinning is a skill that requires high levels of anatomical knowledge, spatial awareness, and hand-eye coordination. We developed a simulation model using silicone soft-tissue and 3D-printed bones to allow development and practice of this skill at no additional risk to patients. For this model, we have focused on reusability and lowering raw-material costs without compromising fidelity. To achieve this, the initial bone model was extracted from open-source computed tomography scans and modified from adult to paediatric size. Muscle of appropriate robustness was then sculpted around the bones using 3D modelling software. A cutaneous layer was developed to mimic oedema using clay sculpturing on a plaster-casted paediatric forearm. These models were then used for 3D-printing and silicone casting respectively. The bone models were printed with settings to imitate cortical and cancellous densities and give high-fidelity tactile feedback upon drilling. Each humerus costs NZD $0.30 in material to print and can be used 1–3 times. Silicone casting of the soft-tissue layers imitates differing relative densities between muscle and oedematous cutaneous tissue, thereby increasing skill necessary to accurately palpate landmarks. Each soft-tissue sleeve cost NZD $70 in material costs to produce and can be used 20+ times. The resulting model is modular, reusable, and replaceable, with each component standardised and easily reproduced. It can be used to practice land-mark palpation and Kirschner wire pinning and is especially valuable in smaller centres which may not be able to afford traditional Saw Bones models. This low-cost model thereby improves equity while maintaining quality of simulation training

Iliopsoas tendonitis occurs in up to 30% of patients after hip resurfacing arthroplasty (HRA) and is a common reason for revision. The primary purpose of this study was to validate our novel computational model for quantifying iliopsoas impingement in HRA patients using a case-controlled investigation. Secondary purpose was to compare these results with previously measured THA patients. We conducted a retrospective search in an experienced surgeon's database for HRA patients with iliopsoas tendonitis, confirmed via the active hip flexion test in supine, and control patients without iliopsoas tendonitis, resulting in two cohorts of 12 patients. The CT scans were segmented, landmarked, and used to simulate the iliopsoas impingement in supine and standing pelvic positions. Three discrete impingement values were output for each pelvic position, and the mean and maximum of these values were reported. Cup prominence was measured using a novel, nearest-neighbour algorithm. The mean cup prominence for the symptomatic cohort was 10.7mm and 5.1mm for the asymptomatic cohort (p << 0.01). The average standing mean impingement for the symptomatic cohort was 0.1mm and 0.0mm for the asymptomatic cohort (p << 0.01). The average standing maximum impingement for the symptomatic cohort was 0.2mm and 0.0mm for the asymptomatic cohort (p << 0.01). Impingement significantly predicted the probability of pain in logistic regression models and the simulation had a sensitivity of 92%, specificity of 91%, and an AUC ROC curve of 0.95. Using a case-controlled investigation, we demonstrated that our novel simulation could detect iliopsoas impingement and differentiate between the symptomatic and asymptomatic cohorts. Interestingly, the HRA patients demonstrated less impingement than the THA patients, despite greater cup prominence. In conclusion, this tool has the potential to be used preoperatively, to guide decisions about optimal cup placement, and postoperatively, to assist in the diagnosis of iliopsoas tendonitis

Introduction. Derotation osteotomies are commonly performed in paediatric orthopaedic and limb reconstruction practice. The purpose of this study was to determine whether the use of a digital inclinometer significantly improves the accuracy in attaining the desired correction. Materials & Methods. We designed an electronic survey regarding derotation femoral osteotomy (DFO) including methods of intra-operative angular correction assessment and acceptable margins of error for correction. This was distributed to 28 paediatric orthopaedic surgeons in our region. A DFO model was created, using an anatomic sawbone with foam covering. 8 orthopaedic surgeons each performed two 30-degree DFOs, one using K-wires and visual estimation (VE), and the other using a Digital Inclinometer (DI). Two radiologists reported pre and post procedure rotational profile CT scans to assess the achieved rotational correction. Results. There was a 68% response rate to the survey. The most popular methods of estimating intra-operative correction were reported to be K-wires and rotation marks on bone. The majority of respondents reported that a 6–10 degree margin of error was acceptable for a 30-degree derotation. This was therefore set as the upper limit for acceptable error margin in the simulation study. The mean error in rotation in the VE group of simulated DFO was 19.7 degrees, with error>5 degrees and error>10 degrees in 7 (88%) and 6 (75%) cases respectively. Mean error in DI group was 3.1 degrees, with error>5 degrees in 1 case (13%). Conclusions. Our results show that the compared to conventional techniques, the use of an inclinometer significantly improves the accuracy of femoral de-rotation and significantly reduces the incidence of unacceptable errors in correction. We would suggest that digital inclinometers be used to assess intra-operative correction during derotation osteotomies

We share our experiences in designing a complete simulator prototype and provide the technological basis to determine whether an immersive medical training environment for vertebroplasty is successful. In our study, the following key research contributions were realised: (1) the effective combination of a virtual reality surgical simulator and a computerised mannequin in designing a novel training setup for medical education, and (2) based on a user-study, the quantitative evaluation through surgical workflow and crisis simulation in proving the face validity of our immersive medical training environment. Medical simulation platforms intend to assist and support surgical trainees by enhancing their skills in a virtual environment. This approach to training is consistent with an important paradigm shift in medical education that has occurred over the past decade. Surgical trainees have traditionally learned interventions on patients under the supervision of a senior physician in what is essentially an apprenticeship model. In addition to exposing patients to some risk, this tends to be a slow and inherently subjective process that lacks objective, quantitative assessment of performance. By proposing our immersive medical simulator we offer the first shared experimental platform for education researchers to design, implement, test, and compare vertebroplasty training methods. We collected feedback from two expert and two novice residents, on improving the teaching paradigm during vertebroplasty. In this way, this limits the risks of complications during the skill acquisition phase that all learners must pass through. The complete simulation environment was evaluated on a 5-pt Likert scale format: (1) strongly disagree, (2) disagree, (3) neither agree nor disagree, (4) agree, and (5) strongly agree. When assessing all aspects of the realism of the simulation environment, specifically on whether it is suitable for the training of technical skills team training, the participating surgeons gave an average score of 4.5. Additionally, we also simulated a crisis simulation. During training, the simulation instructor introduced a visualisation depicting cement extravasation into a perivertebral vein. Furthermore, the physiology of the computerised mannequin was influenced by the instructor simulating a lung embolism by gradually lowering the oxygen saturation from 98% to 80% beginning at a standardised point during the procedure. The simulation was stopped after the communication between the surgeon and the anaesthetist occurred which determined their acknowledgment that an adverse event occurred. The realism of this crisis simulation was ranked with an average score of 4.75. To our knowledge this is the first virtual reality simulator with the capacity to control the introduction of adverse events or complication yielding a wide spectrum of highly adjustable crisis simulation scenarios. Our conclusions validate the importance of incorporating surgical workflow analysis together with virtual reality, human multisensory responses, and the inclusion of real surgical instruments when considering the design of a simulation environment for medical education. The proposed training environment for individuals can be certainly extended to training medical teams

Introduction. Geometric variations of the hip joint can give rise to abnormal joint loading causing increased stress on the articular cartilage, which may ultimately lead to degenerative joint disease. In-vitro simulations of total hip replacements (THRs) have been widely reported in the literature, however, investigations exploring the tribology of two contacting cartilage surfaces, and cartilage against metal surfaces using complete hip joint models are less well reported. The aim of this study was to develop an in-vitro simulation system for investigating and comparing the tribology of complete natural hip joints and hemiarthroplasties with THR tribology. The simulation system was used to assess natural porcine hip joints and porcine hemiarthroplasty hip joints. Mean friction factor was used as the primary outcome measure to make between-group comparisons, and comparisons with previously published tribological studies. Method. In-vitro simulations were conducted on harvested porcine tissue. A method was developed enabling natural acetabula to be orientated with varying angles of version and inclination, and natural femoral heads to be potted centrally with different orientations in all three planes. Acetabula were potted with 45° of inclination and in the complete joint studies, natural femoral heads were anatomically matched and aligned (n=5). Hemiarthroplasty studies (n=5) were conducted using cobalt chrome (CoCr) heads mounted on a spigot (Figure 1), size-matched to the natural head. Natural tissue was fixed using PMMA (polymethyl methacrylate) bone cement. A pendulum friction simulator (Simulator Solutions, UK), with a dynamic loading regime of 25–800N, ± 15° flexion-extension (FE) at 1 Hertz was used. The lubricant was a 25% (v/v) bovine serum. Axial loading and motion was applied through the femoral head and frictional torque was measured using a piezoelectric transducer, from which the friction factor was calculated. Results. The correct anatomical orientation and positioning was achieved enabling in-vitro simulation testing to be conducted on hemiarthroplasty and complete hip joint samples for two-hours. Mean friction increased rapidly followed by a continued gradual increase to ≈0.03 ± 0.00 in the complete joints, with the hemiarthroplasty group plateauing at ≈0.05 ± 0.01 (Figure 2). Mean friction factor was significantly lower (t-test; p < 0.05) in the complete natural joint group. Discussion. An in-vitro simulation system for the natural hip joint with controlled orientation of the femur and acetabulum was successfully developed and used to measure friction in complete porcine hip joints and porcine hip hemiarthroplasties. A non-linear increase in friction indicative of biphasic lubrication was observed in both groups with slower exudation of fluid from the complete joints compared to the hemiarthroplasties, inferring a quicker move towards solid-phase lubrication. Higher friction in the hemiarthroplasties, which was similar to that measured in-vitro in metal-on-polyethylene THRs, was most likely due to variable clearances between the non-conforming spherical metal head and aspherical acetabulum, causing poorer congruity and distribution of the load. This could in time lead to abrasive wear and cartilage degradation. This methodology could have an important role when investigating associations between hip geometric variations, interventions for hip disease/pathology, and risk factors for cartilage degeneration

Introduction. Loads acting on the knee are tied to the long term performance of implants, and are directly related to ligament function [1]. Previous work has used computational models coupled with optimization to estimate ligament properties based on experimental joint kinematics [2]. Our group recently utilized a similar optimization scheme that estimated ligament slack lengths based on experimental implant contact metrics [3]. A comparison with surgically relevant loading conditions that were excluded from the optimization would help establish the utility of the simulation framework. Hence, the purpose of this study was to assess the predictive capability of two simulated knees using comparisons with experimentally determined trends found after systematic removal of key tissues. Similar techniques may support clinical joint balancing techniques, as well as identify factors that dictate long term implant performance. Methods. Knee arthroplasty was performed by orthopedic surgeons for four cadaveric specimens. Instrumented trial inserts (VERASENSE, OrthoSensor, Inc., Dania Beach, FL) were used and experimentation utilized the simVITROTM robotic musculoskeletal simulator (Cleveland Clinic, Cleveland, OH) to measure tibiofemoral kinematics under interoperative style loading. Three successive laxity style tests were performed at 10° flexion: anterior-posterior force (±100 N), varus-valgus moment (±5 Nm), and internal-external moment (±3 Nm). Kinematics and implant forces were measured throughout testing. Specimens were first tested in the intact state, then the laxity tests were repeated after systematic release of the posterior cruciate ligament (PCL), superficial medial collateral ligament (sMCL), or popliteus (POP). Significant changes in kinematics and contact metrics were determined using regression analysis between the intact versus the tissue released states. Finite element models were developed for two specimens, and optimized ligament slack lengths were found using methods described previously [3] (Fig. 1). The experimental laxity style loads were applied to both optimized models with intact ligaments, and with individually released PCL, sMCL, or POP ligaments. Knee kinematics and tibial contact loads were predicted, and trended responses from the intact simulations to those with released ligaments were determined (i.e. higher, lower or no change). Simulation results were then compared with the statistically significant findings from the experimental tests. Results and Discussion. Both models generally recreated the significant experimental trends. Specimen 3 recreated 8 of the 9 directional changes, while specimen 4 realized 7 of the 9 (Table 1). Release of the POP in specimen 4 contradicted both specimen 3 and the experimental results. This may highlight specimen-specific behavior, or a misrepresentation of the tissue restraint on the posterolateral corner. Ongoing testing and simulation will evaluate areas of discrepancy, with particular focus on specimen specific mechanics. This work shows that simulation can estimate significant trends in physical testing. The framework demonstrates promise for development of a tool to understand the consequences of intra-operative tissue balancing. Future work will investigate representation of the posterolateral corner, and evaluate the predictive capacity for the absolute specimen-specific changes in joint mechanics due to tissue release. Acknowledgements. Orthosensor Inc. For any figures or tables, please contact authors directly (see Info & Metrics tab above).

Introduction. Total knee arthroplasty (TKA) prostheses are semi-constrained artificial joints. A well-functioning TKA prosthesis should be designed with a good balance between stability and mobility, meaning the femorotibial constraint of the artificial joint should be appropriate for the device's function. To assess the constraint behavior of a TKA prosthesis, physical testing is typically required, and an industrial testing standard has been developed for this purpose [1]. Computer simulation has become increasingly useful in many industries, including medical device research and development where finite element analysis (FEA) has been extensively used in stress analysis and structural evaluation. This study presents an FEA-based simulation to evaluate the femorotibial constraint behavior of TKA prosthesis, and demonstrated the effectiveness of the method by validating through physical testing. Methods. A Cruciate Retaining (CR) TKA prosthesis design (Optetrak Logic CR, Exactech, USA) was used in this study. CAD models of the implants assembled at 0° of flexion were used for the simulation. Finite element models were generated using with all materials assumed linear elastic. Boundary conditions were set up according to the ASTM F1223 standard (Figure 1). The tibial baseplate was fixed distally. A constant compressive force (710 N) was applied on the femoral component. Nonlinear Surface-Surface-Contact was defined at the femorotibial articulating surfaces. Coefficient of friction was determined from physical test. The femoral component was driven under a displacement-controlled scheme to slide along the anterior-posterior (AP) direction on the tibial insert. At each time step, constraint force occurring at the articulating surface was derived from the reaction force at the distal fixation of the tibial baseplate. A nonlinear FEA solver (NX Nastran SOL601, Siemens, USA) was used to solve the simulation. In addition, five samples of the prostheses were physically tested, and the results were compared with the simulation. Results. The simulation successfully captured the movement of contact location and pressure along the movement of the femoral component (Figure 2). The force-displacement curve predicted by the simulation exhibited a very close hysteresis loop profile as the results of physical testing (Figure 3). Using the curve slope from 0 to 5 mm to characterize the linear constraint, the simulation predicted 45.7 N/mm anteriorly and 36.4 N/mm posteriorly, which are less than 10% different from the physical testing results (46.4 N/mm anteriorly and 39.6 N/mm posteriorly). Discussion/Conclusion. This study demonstrated that the simulation was able to closely predict the femorotibial constraint behavior of the TKA prosthesis under ASTM F1223 testing. The simulation results resembled the physical testing results not only in the general curve profile but also in the magnitude of slope values. The increased difference at the far anterior region could be related to the fact that no material nonlinearity was currently considered, which could be improved in future studies. A validated simulation method could be very useful in TKA prosthesis design. Since no physical prototypes are required, design evaluation and optimization can be achieved in a much easier and faster manner

Introduction. Experimental wear simulation of an all-polymer knee implant has shown an equivalent rate of wear of UHMWPE tibial components against PEEK-OPTIMA™ and cobalt chrome femoral components of a similar initial geometry and surface topography. However, when the patella is resurfaced with an UHMWPE patella button, it is important to also ascertain the wear of the patella. Wear debris from the patella contributes to the total volume of wear debris produced by the implant which should be minimised to reduce the potential for osteolysis and subsequent implant loosening. The aim of this study was to investigate the wear of the patellofemoral joint in an all-polymer knee implant. The wear of UHMWPE patellae articulating against PEEK-OPTIMA™ femoral components was compared to UHMWPE articulating against cobalt chrome femoral components. Materials and Methods. Six mid-size (size C) PEEK-OPTIMA™ femoral components (Invibio Knee Ltd., UK) and six cobalt chrome femoral components of similar initial surface topography and geometry were coupled with 28mm all-polyethylene GUR1020 patellae (conventional, EO sterile) (Maxx Orthopaedics, USA). The implants were set up in a ProSim 6 station electromechanical knee simulator (Simulation Solutions, UK) which was modified for testing the patellofemoral joint. 3 million cycles (MC) of wear simulation was carried out under kinematics aiming to replicate a gait cycle adapted for an electromechanical simulator from previous work by Maiti et al. The simulator used has six degrees of freedom of which four were controlled; axial force up to 1200N, flexion/extension 22°, superior-inferior (SI) displacement (22mm) and Abduction-adduction (AA) (4°). The SI and AA were displacement controlled and driven through the patella. The medial-lateral displacement and tilt (internal/external rotation) of the patella were passive so the patella button was free to track the trochlear groove. The lubricant used was 25% bovine serum supplemented with 0.03% sodium azide to retard bacterial growth. The wear of patellae was determined gravimetrically with unloaded soak controls used to compensate for the uptake of moisture by the UHMWPE. The mean wear rate ± 95% confidence limits were calculated and statistical analysis was carried out using ANOVA with significance taken at p<0.05. Results. The mean wear rates of the UHMWPE patellae were 0.26±0.21 mm. 3. /MC and 0.35±0.17 mm. 3. /MC against PEEK-OPTIMA™ and cobalt chrome femoral components respectively. There was no significant difference in wear rate against the different femoral component materials (P=0.38). Against both femoral component materials, a ‘bow tie’ shaped wear scar was evident on the patellae typical of that seen in retrieval studies and reported in previous experimental wear simulation of the patellofemoral joint. Conclusion. The wear rate of the UHMWPE patellae was low against both PEEK-OPTIMA™ and cobalt chrome femoral components and comparable to previous work by Vanbiervliet et al. This study further shows that in terms of its wear performance, PEEK-OPTIMA™ has promise as an alternative bearing material to cobalt chrome in the femoral component of total knee replacements

“Simulation”, “deliberate practice”, “rehearsal” have been used to describe safe acquisition and practice of skills before patient contact. Simulation resources are being introduced as a General Medical Council mandate. Individual simulators have shown multi-level evidence but there is no guidance to form a simulation curriculum. We devised a pilot arthroscopy course based on a 4-stage model. Stage 1: session covering anatomy, equipment, and skills required; Stage 2: practice on low fidelity simulators (Arthroscopic Skills Acquisition Tools (ASATs), ArthroBox, Synthetic Knee); Stage 3: practice on high fidelity simulators (Cadaveric Knee, Virtual Reality); Stage 4: assessment on performance intra-operatively. This study sought feedback on Stages 1–3 with the aim that the feedback will help identify how trainees wish to use simulators. Five arthroscopic simulators were used in this one-day pilot course. Prior to commencing, participants were asked which simulator they felt would help them the most. Feedback on each stage, and individual simulator (Likert scale), and how trainees would like to be trained was prospectively collected. Seven orthopaedic juniors took part. All felt the high-fidelity simulators will be the most useful. All stages were ranked with equal importance, whilst cadaveric, plastic, VR, Arthrobox and lastly ASATs ranked in order of realism respectively. For cadaveric arthroscopy trainees wished the trainers to be there all the time (6/7), whilst for VR all trainees wanted their trainers part of the time. We have shown that junior trainees value a structured method of skills acquisition and have identified that high fidelity simulation requires trainers to be present to provide relevant feedback. Such feedback mechanisms need to be incorporated in any curriculum so that simulation tools are not seen as a standalone training method

With the advancement of the virtual technologies, three-dimensional surgical simulators are now possible. In this article, we describe an immersive simulation platform, allowing students in orthopaedic surgery to learn how to deal with a sample diaphyseal fracture of the femur using LC-DCP plate hole, cortical screw and verbrugge forceps. To reach certain realism, weight of the objects and force feedback are used in addition to the visual scene and the 3D sound. The students feel the weight, the strength of the bone when they pierce the holes, and the vibration of the drill. The simulation is implemented by using CAVE, the CyberGlove, CyberGrasp, and 3D sound system

INTRODUCTION. While computational models have been used for many years to contribute to pre-clinical, design phase iterations of total knee replacement implants, the analysis time required has limited the real-time use as required for other applications, such as in patient-specific surgical alignment in the operating room. In this environment, the impact of variation in ligament balance and implant alignment on estimated joint mechanics must be available instantaneously. As neural networks (NN) have shown the ability to appropriately represent dynamic systems, the objective of this preliminary study was to evaluate deep learning to represent the joint level kinetic and kinematic results from a validated finite element lower limb model with varied surgical alignment. METHODS. External hip and ankle boundary conditions were created for a previously-developed finite element lower limb model [1] for step down (SD), deep knee bend (DKB) and gait to best reproduce in-vivo loading conditions as measured on patients with the Innex knee (. orthoload.com. ) (Figure1). These boundary conditions were subsequently used as inputs for the model with a current fixed-bearing total knee replacement to estimate implant-specific kinetics and kinematics during activities of daily living. Implant alignments were varied, including variation of the hip-knee-ankle angle-±3°, the frontal plane joint line −7° to +5°, internal-external femoral rotation ±3°, and the tibial posterior slope 5° and 0°. Through varying these parameters a total of 2464 simulations were completed. A NN was created utilizing the NN toolbox in MATLAB. Sequence data inputs were produced from the alignment and the external boundary conditions for each activity cycle. Sequence outputs for the model were the 6 degree of freedom kinetics and kinematics, totaling 12 outputs. All data was normalized across the entire data set. Ten percent of the simulation runs were removed at random from the training set to be used for validation, leaving 2220 simulations for training and 244 for validation. A nine-layer bi-long short-term memory (LSTM) NN was created to take advantage of bi-LSTM layers ability to learn from past and future data. Training on the network was undertaken using an RMSprop solver until the root mean square error (RMSE) stopped reducing. Evaluation of NN quality was determined by the RMSE of the validation set. RESULTS. The trained NN was able to effectively estimate the validation data. Average RMSE over the kinetics of the validation data set was 140.7N/N∗m while the average RMSE over the kinematics of the validation data set was 4.47mm/deg (Figure 2,3–DKB, Gait shown). It is noted the error may be skewed by the larger magnitude kinetics and kinematics in the DKB activity as the average RMSE for just SD and gait was 85.9N/N∗m and 2.8mm/deg for the kinetics and kinematics, respectively. DISCUSSION. The accuracy of the generated NN indicates its potential for use in real-time modeling, and further work will explore additional changes in post-operative soft-tissue balance as well as scaling to patient-specific geometry

Introduction. Total knee arthroplasty (TKA) is a well proven surgical procedure. Squat and gait motions are common activities in daily life. However, squat motion is known as most dissatisfying motion in activities in daily life after total knee arthroplasty (TKA). Dissatisfaction after TKA might refer to muscle co-contraction between quadriceps and hamstrings. The purposed of this study was to develop squat and gait simulation model and analyses the contact mechanics and quadriceps and hamstring muscle stability. We hypothesized that squat model shows larger contact forces and lower hamstring to quadriceps force ratio than gait model. Materials and Methods. Squat motion and gait model were simulated in musculoskeletal simulation software (AnyBody Modeling System, AnyBody Technology, Denmark). Subject-specific bone models used in the simulation were reconstructed from CT images by Mimics (Materialize, Belgium). The lower extremity model was constructed with pelvis, femur, tibia, foot segments and total knee replacement components: femoral component, tibial insert, tibial tray, and patella component [Fig.1]. The muscle model was consisted of 160 muscle elements. The TKR components used in this study are PS-type LOSPA Primary Knee System (Corentec Co., Ltd, Republic of Korea). Force-dependent kinematics method was used in the simulation. The model was simulated to squat from 15° to 100° knee flexion, in 100 frames. Gait simulation model was based on motion capture and force-plate system. Motion capture and force-plate data were from grand challenge competition dataset. Results / Discussion. Patellofemoral contact forces ranged from 0.18 to 3.78 percent body weight (%BW) and from 0.00 to 1.36 %BW during squat motion and gait cycle, respectively. Patellofemoral contact forces calculated at 30°, 60°, and 90° flexion during squat motion were 0.53, 1.93, and 3.22 %BW, respectively. Wallace et al. also reported patellofemoral contact forces at 30°, 60°, and 90° flexion, which were 0.31, 1.33, 2.45 %BW during squat motion. Our results showed similar results from other studies, however the squat model overestimated the patellofemoral contact forces. Contact stiffness in the simulation model might affected the overestimated contact forces. Hamstring to quadriceps force ratio ranged from 0.32 to 1.88 for squat model, and from 0.00 to 2.54 for gait model. As our hypothesis, squat motion showed larger patellofemoral contact forces. Also, mean hamstring to quadriceps force ratio of squat model were about half than the mean hamstring to quadriceps force ratio of gait model. From the results, possibility exists that unbalanced force of quadriceps and hamstring can affect dissatisfaction after TKA while squat motion is the most dissatisfying motion after TKA. However, muscle stability is not the only factor that can affect dissatisfaction after TKA. In future study, more biomechanical parameters should be evaluated to find meaningful dissatisfying factor after TKA. Conclusion. In conclusion, TKA musculoskeletal models of squat and gait motion were constructed and patellofemoral contact force / hamstring to quadriceps force ratio were evaluated. Patellofemoral mechanics were validated by comparison of previous study. Additional studies are needed to find dissatisfying factor after TKA

Skills simulation is increasingly used as a training tool in postgraduate surgical training. Trainee's perception of the value of this experience has not previously been investigated. Our aim was to investigate the value of surgical simulation training delivered by an arthroscopy skills course. We constructed a subject-specific, self-assessment questionnaire based around the ISCP Peer Assessment Tool. The questionnaire was administered to candidates before and after attending the Plymouth Arthroscopy Skills Course. Participant demographic data was recorded. Questionnaire data was interrogated to give an overview of the course, as well as the benefit of site-specific skills stations. Statistical analysis showed the data to be normally distributed. The paired T-test was used to compare mean values. Twelve surgical trainees attended the course – CT2 trainees (n=4); ST3 trainees (n=7); ST4 trainee (n=1). 11 candidates completed both administered questionnaires giving a 92% response rate. The global mean score at the beginning of the course was 2.39. The global mean score at the end of the course was 3.90. The mean improvement was 1.51 (p<0.01; 95% CI = 0.96–2.07). Skill station specific scores all showed improvement with the greatest effect in wrist arthroscopy. CT trainees had a lower mean score compared to ST trainees. Both groups completed the course with similar mean scores. This study shows that arthroscopy simulation improves trainee-reported ratings of surgical skill. It also shows that less experienced candidates derived the greatest benefit from the training. Further research is required to compare self-assessed performance against objective benchmarks using validated assessment tools

Skills simulation is increasingly used as a training tool in postgraduate surgical training. Trainee's perception of the value of this experience has not previously been investigated. The aim of this investigation was to investigate the value of surgical simulation training delivered by an arthroscopy skills course. We constructed a subject-specific, self-assessment questionnaire based around the ISCP Peer Assessment Tool. The questionnaire was administered to candidates before and after attending the Plymouth Arthroscopy Skills Course. Participant demographic data was recorded. Questionnaire data was interrogated to give an overview of the course, as well as the benefit of site-specific skills stations. Statistical analysis showed the data to be normally distributed. The paired T-test was used to compare mean values. Twelve surgical trainees attended the course – CT2 trainees (n=4); ST3 trainees (n=7); ST4 trainee (n=1). 11 candidates completed both administered questionnaires giving a 92% response rate. The global mean score at the beginning of the course was 2.39. The global mean score at the end of the course was 3.90. The mean improvement was 1.51 (p<0.01; 95% CI= 0.96-2.07). Skill station specific scores all showed improvement with the greatest effect in wrist arthroscopy. CT trainees had a lower mean score compared to ST trainees. Both groups completed the course with similar mean scores. This study shows that arthroscopy simulation improves trainee-reported ratings of surgical skill. It also shows that less experienced candidates derived the greatest benefit from the training. Further research is required to compare self-assessed performance against objective benchmarks using validated assessment tools

Introduction. Fretting corrosion at the taper interface has been implicated as a possible cause of implant failure. Using in-vitro testing, fretting wear observed at tapers of retrieved implants may be reproduced (Marriott, EORS-2014). In order to reduce time and cost associated with experimental testing, a validated finite element method (FE) can be employed to study the mechanics at the taper. In this study we compared experimental and representative FE simulations of an accelerated fretting test set-up. Comparison was made by between the FE wear score and volumetric material loss from the testing. Methods. Experimental test set-up: An accelerated wear test was developed that consistently reproduced fretting wear features observed in retrievals. Biomet stems with smooth 4° Type-1 tapers were combined with Ti6Al4V Magnum +9 mm adaptors using a 2 or 15 kN assembly force. The head was replaced with a custom head fixture to increase the offset and apply a torque at the taper interface. The stems were potted according to ISO 7206-6:2013. The set-up was submerged in a test medium containing PBS and 90gl-1 NaCl. The solution was pH adjusted to 3 using HCl and maintained at 37°C throughout the tests. For each assembly case, n=3 tests were cyclically loaded between 0.4–4 kN for 10 Million cycles. Volumetric wear measurements were performed using a Talyrond-365 roundness measurement machine. The FE model was created to replicate the experimental set up. Geometries and experimental material data were obtained from the manufacturer (Biomet). The same assembly forces of 2 and 15 kN were applied, and the same head fixture was used for similar offset and loading conditions. The 4 kN load was applied at the same angles in accordance with ISO 7206-6:2013. Micromotions and contact pressures were calculated, and based on these a wear score was determined by summation over all contact points. Results. The FE wear score showed a significant drop after an assembly force of 15 kN has been applied. The micromotion scores were similar, and the contact pressure was higher due to the larger assembly force. The volumetric wear measurements did not show a significant difference between the two assembly cases due to the large variation in measured values. A downward trend can be observed when applying higher assembly forces, similar to the trend seen at the FE wear score (figure 1, table1). Discussion. This study shows a correlation between experimental and FE simulation, however highlights the difficulty in validating a FE model with complex in-vitro experiments. Due to the nature of experimental testing, it is impossible to remove all sources of error associated with the set-up. The use of a single static load and the absence of fluids and corrosion processes means that the full mechanics of the wear process could not be fully replicated. Despite these deficiencies the general trends and wear patterns observed in the experimental setup were reproduced. Further studies will focus on including the interplay between the aforementioned properties, to provide a better simulation of the fretting processes occurring at the taper junction

The alignment of prostheses components has a major impact on the longevity of total knee protheses as it significantly influences the biomechanics and thus also the load distribution in the knee joint. Knee joint loads depend on three factors: (1) geometrical conditions such as bone geometry and implant position/orientation, (2) passive structures such as ligaments and tendons as well as passive mechanical properties of muscles, and (3) active structures that are muscles. The complex correlation between implant position and clinical outcome of TKA and later in vivo joint loading after TKA has been investigated since 1977. These investigations predominantly focused on component alignment relative to the mechanical leg axis (Mikulicz-line) and more recently on rotational alignment perpendicular to the mechanical axis. In general four different approaches can be used to study the relationship between implant position and knee joint loads: In anatomical studies (1), the influence of the geometrical conditions and passive structures can be analyzed under the constraint that the properties of vital tissue are only approximated. This could be overcome with an intraoperative load measurement approach (2). Though, this set up does not consider the influence of active structures. Although post-operative in vivo load measurements (3) provide information about the actual loading condition including the influence of active structures, this method is not applicable to investigate the influence of different implant positions. Using mathematical approaches (4) including finite element analysis and multi-body-modeling, prostheses positions can be varied freely. However, there exists no systematical analysis of the influence of prosthesis alignment on knee loading conditions not only in axial alignment along and rotational alignment perpendicular to the mechanical axis but in all six degrees of freedom (DOF) with a validated mathematical model. Our goal was therefore to investigate the correlation between implant position and joint load in all six DOF using an adaptable biomechanical multi-body model. A model for the simulation of static single leg stance was implemented as an approximation of the phase with the highest load during walking cycle. This model is based on the AnyBody simulation software (AnyBody Technology A/S, Denmark). As an initial approach, with regard to the simulation of purely static loading the knee joint was implemented as hinge joint. The patella was realised as a deflection point, a so called “ViaNode,” for the quadriceps femoris muscle. All muscles were implemented based on Hill's muscle model. The knee model was indirectly validated by comparison of the simulation results for single and also double leg stance with in-vivo measurements from the Orthoload database (www.orthoload.de). For the investigation of the correlation between implant position and knee load, major boundary conditions were chosen as follows:. •. Flexion angle was set to 20° corresponding to the position with the highest muscle activity during gait cycle. •. Muscle lengths and thereby also muscle loads were adapted to the geometrical changes after each simulation step representing the situation after post-operative rehabilitation. As input parameters, the tibial and femoral components' positions were independently translated in a range of ±20mm in 10 equally distant steps for all three spatial directions. For the rotational alignment in adduction/abduction as well as flexion/extension the tibial and femoral components' positions were varied in the range of ±15° and for internal/external rotation within the range of ±20°, also in 10 equally angled steps. Changes in knee joint forces and torques as well as in patellar forces were recorded and compared to results of previous studies. Comparing the simulation results of single and double leg stance with the in-vivo measurements from the Orthoload database, changes in knee joint forces showed similar trends and the slope of changes in torques transmitted by the joint was equal. Against the background of unknown geometrical conditions in the Orthoload measurements and the simplification (hinge joint) of the initial multi-body-model compared to real knee joints, the developed model provides a reasonable basis for further investigations already – and will be refined in future works. As influencing parameters are very complex, a non-ambiguous interpretation of force/torque changes in the knee joint as a function of changes in component positions was in many cases hardly possible. Changes in patella force on the other hand could be traced back to geometrical and force changes in the quadriceps femoris muscle. Positional changes mostly were in good agreement with our hypotheses based on literature data when knee load and patellar forces respectively were primarily influenced by active structures, e.g. with regard to the danger of patella luxation in case of increased internal rotation of the tibial component. Whereas simulations also showed results contradicting our expectations for positional changes mainly affecting passive structures, e.g. cranial/caudal translation of the femoral component. This shows the major drawback of the implemented model: Intra-articular passive structures such as cruciate and collateral ligaments were not represented. Additionally kinematic influences on knee and patella loading were not taken into account as the simulations were made under static conditions. Implementation of relative movements of femoral, tibial and patella components and simulation under dynamic conditions might overcome this limitation. Furthermore, the boundary condition of complete muscle adaptations might be critical, as joint loads might be significantly higher shortly after operation. This could lead to a much longer and possibly ineffective rehabilitation process

Introduction. The number of young and more active patients requiring total knee replacement (TKR) is increasing. Preclinical evaluation and understanding the long-term failure of TKR is therefore important. Preclinical wear simulation of TKR is usually performed according to the International Standards Organization (ISO) recommendations. Two international standards for preclinical wear simulation of TKRs have been developed so that the anterior-posterior (AP) translation and internal-external (IE) rotation can be driven in either force or displacement control. However, the effects of using different control regimes on the kinematics and wear of the same TKR have not been investigated. The current study investigated the kinematics, contact mechanics and wear performance of a TKR when running under ISO force and displacement control standards using an experimentally validated computational model. Materials/Methods. Three different ISO control standards were investigated using a size C Sigma curved TKR (DePuy, UK), with moderately cross-linked UHMWPE curved inserts; ISO-14243-3-2004, ISO-14243-3-2014 and ISO- 14243-1-2009. Axial force and flexion-extension angle are common for the three standards. AP and IE motions are displacement controlled in ISO-14243-3-2004 and ISO-14243-3-2014, with the only difference being a reversal of AP polarity between the two standards, and are force controlled in ISO-14243-1-2009. The test setup and soft tissue constraints were defined in accordance with ISO recommendations. The wear model was based on the modification of Archard's law where the wear volume is defined as a function of contact area, sliding distance, cross-shear and contact stress. The simulation framework has been independently validated against experimental wear rates under three different standard and highly demanding daily activities (Abdelgaied et al. 2018). Results. Reversing AP in the displacement control ISO-2014, compared to ISO-2004, resulted in high contact stresses of more than 70 MPa in the posterior direction. The predicted AP and IE from the force control ISO-2009 were in different directions and magnitudes to ISO-2014 AP and IE. The predicted wear rates were 1.8, 2.0, and 5.5 [mm. 3. /mc] for ISO-14243-3-2004, ISO-14243-3-2014 and ISO-14243-1-2009 respectively. Discussion. Reversing AP in the displacement control ISO-2014, without revising the femoral centre of rotation, resulted in high stress edge loading in the posterior direction, due to femoral rollback, and more than 10% increase in wear rate compared to ISO-2004. The predicted AP and IE from the force control ISO-2009 had different polarities and magnitudes to the corresponding displacement control ISO-2014 AP and IE. In addition, the predicted wear rate under the force control ISO-2009 was more than double that measured under displacement control standards due to the increased AP and IE motions predicted under the force control standard. In addition to the previous validation of the model, the predicted wear rate under the force control ISO-2009 of 5.5 mm. 3. /mc was within the 95% confidence limits of the reported experimental wear rate for the same TKR of 4.71±1.29 mm. 3. /mc (Johnston et al. 2018) which gives more confidence in the model. Conclusion. The study showed significant differences between ISO force and displacement control standards and between ISO displacement standards with different AP polarities. These differences should therefore be considered when choosing a control regime for preclinical simulation of TKR

INTRODUCTION. Knee simulators are being used to evaluate wear. The current international standards have been developed from clinical investigations of the normal knee [1, 2] or from a single TKA patient [3, 4]. However, the forces and motions in a TKA patient differ from a normal knee and, furthermore, the resulting kinematic outcomes after TKA will depend on the design of the device [5]. Consequently, these standard tests may not recreate in-vivo conditions; therefore, the goal of this study was to perform a novel wear simulation using design-specific inputs that have been derived from fluoroscopic images of a deep knee bend. METHODS. A wear simulation was developed using fluoroscopic data from a pool of eighteen TKA patients performing a deep knee bend. All patients had a Sigma CR Fixed Bearing implant (DePuy) and were well functioning (Knee Society Score > 90). A single patient was selected that represented the typical motions, which was characterized by early rollback followed by anterior motion with an overall modest internal tibial rotation (Figure 1). The relative motion between the femoral and tibial components was transformed to match the coordinate system of an AMTI knee wear simulator [6] and a compressive load input was derived using inverse dynamics [7]. The resulting force and motions (Figure 2) were then applied in a wear simulation with 5 MRad crosslinked and remelted polyethylene for 3 Mcyc at 1 Hz. Components were carefully positioned and each joint (n=3) was tested in 25% bovine calf serum (Hyclone Laboratories), which was recirculated at 37±2°C [3]. Serum was supplemented with sodium azide and EDTA. Wear was quantified gravimetrically every 0.5 Mcyc using a digital balance (XP250, Mettler-Toledo) with load soak compensation. RESULTS. The knee simulator was able to recreate the in-vivo input kinematics. The femoral low point location revealed good agreement between in-vivo and in-vitro conditions and the overall pattern of the motion from full extension to maximum knee flexion was replicated (Figure 3). The measured wear from these inputs was very low (0.7 ± 0.2 mg/Mcyc). DISCUSSION. We have performed a device-specific wear simulation for a deep knee bend. Surprisingly, the wear associated with this activity was very low. It is possible that abnormal kinematics, including paradoxical anterior slide and reverse rotation, would generate higher wear. The deviations the between in-vivo and in-vitro kinematics (Figure 3) are likely due to a size mismatch across the transformation process. In a previous study [7] we recreated the in-vivo motions with better fidelity (RMS error = 0.6mm) using size matched components. Further work is needed to improve the transformation technique for different sized components. Also, similar approaches will be used in future investigations to study the effect of abnormal kinematics as well as other designs including rotating platform and cruciate substituting devices

Background. Rotational acetabular osteotomy (RAO) is an effective treatment option for symptomatic acetabular dysplasia. However, excessive lateral and anterior correction during the periacetabular osteotomy may lead to femoroacetabular impingement. We used preoperative planning software for total hip arthroplasty to perform femoroacetabular impingement simulations before and after rotational acetabular osteotomies. Methods. We evaluated 11 hips in 11 patients with available computed tomography taken before and after RAO. All cases were female and mean age at the time of surgery was 35.9 years. All cases were early stage osteoarthritis without obvious osteophytes or joint space narrowing. Radiographic analysis included the center-edge (CE) angle, Sharp's acetabular angle, the acetabular roof angle, the acetabular head index (AHI), cross-over sign, and posterior wall sign. Acetabular anteversion was measured at every 5 mm slice level in the femoral head using preoperative and postoperative computed tomography. Impingement simulations were performed using the preoperative planning software ZedHip (LEXI, Tokyo, Japan). In brief, we created a three-dimensional model. The range of motion which causes bone-to-bone impingement was evaluated in flexion (flex), abduction (abd), external rotation in flex 0°, and internal rotation in flex 90°. The lesions caused by impingement were evaluated. Results. In the radiographic measurements, the CE angle, Sharp's angle, acetabular roof angle, and AHI all indicated improved postoperative acetabular coverage. The cross-over sign was recognized pre- and postoperatively in each case. Acetabular retroversion appeared in one case before RAO and in three cases after RAO. Preoperatively, there was a tendency to reduce the acetabular anteverison angle in the hips from distal levels to proximal. In contrast, there was no postoperative difference in the acetabular anteversion angle at any level. In our simulation study, bone-to-bone impingement occurred in flex (preoperative/postoperative, 137°/114°), abd (73°/54°), external rotation in flex 0°(34°/43°), and internal rotation in flex 90°(70°/36°). Impingement occurred within internal rotation 45°in flexion 90°in two preoperative and eight postoperative cases. The impingement lesions were anterosuperior of the acetabulum in all cases. Discussion. It is easy to make and assess an impingement simulation using preoperative planning software, and our data suggest the simulation was helpful in a clinical setting, though there were some remaining problems such as approximation of the femoral head center and differences in femur movement between the simulation and reality. In the postoperative simulation there was a tendency to reduce the range of motion in flex, abd, and internal rotation in flex 90°. There was a correlation between acetabular anteversion angle and flex. Since impingement occurred within internal rotation 45°in flexion 90°in eight postoperative simulations, we consider there is a strong potential for an increase in femoroacetabular impingement after RAO

Introduction. The purpose of this study was to experimentally evaluate impingement and dislocation of total hip replacements while performing dynamic movements under physiological-like conditions. Therefore, a hardware-in-the-loop setup has been developed, in which a physical hip prosthesis actuated by an industrial robot interacts with an in situ-like environment mimicked by a musculoskeletal multibody simulation-model of the lower extremity. Methods. The multibody model of the musculoskeletal system comprised rigid bone segments of the lower right extremity, which were mutually linked by ideal joints, and a trunk. All bone geometries were reconstructed from a computed tomography set preserving anatomical landmarks. Inertia properties were identified based on anthropometric data and by correlating bone density to Hounsfield units. Relevant muscles were modeled as Hill-type elements, passive forces due to capsular tissue have been neglected. Motion data were captured from a healthy subject performing dislocation-associated movements and were fed to the musculoskeletal multibody model. Subsequently, the robot moved and loaded a commercially available total hip prosthesis and closed the loop by feeding the physical contact information back to the simulation model. In this manner, a comprehensive parameter study analyzing the impact of implant position and design, joint loading, soft tissue damage and bone resection was implemented. Results. The parameter study revealed a generally high dislocation risk for the seating-to-rising with adduction scenarios. Improper implant positioning or design could be compensated by adjusting prosthesis components correspondingly. Gluteal insufficiency or lower joint loading did not result in higher impingement or dislocation risk. However, severe malfunction of the artificial joint was found for proximal bone resection. Discussion. Previous testing setups ignored the impact of active muscles or relied on simplified contact mechanics. Herein, total hip replacement stability has been investigated experimentally by using a hardware-in-the-loop simulation. Thereby, several influencing factors such as implant position and design as well as soft tissue insufficiency and imbalance could be systematically evaluated with the goal to enhance joint stability