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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_12 | Pages 49 - 49
23 Jun 2023
McCalden R Pomeroy E Naudie D Vasarhelyi E Lanting B MacDonald S Howard J
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Subsidence remains a concern when utilizing modern tapered fluted titanium (TFT) femoral stems and may lead to leg length discrepancy, impingement, instability and failure to obtain stem osseointegration. This study aims to compare stem subsidence across three modern TFT stems. Our secondary aim was to investigate the influence of bicortical contact or ‘scratch fit’ on subsidence, as well as the role of intraoperative imaging in maximizing this bicortical contact and preventing stem subsidence.

A retrospective review of 271 hip arthroplasties utilizing modern TFT stems in a single institution was performed. Three stem designs were included in the analysis: one monoblock TFT stem (n=91) and two modular TFT stems (Modular A [n=90]; Modular B [n=90]). Patient demographics, Paprosky femoral bone loss classification, bi-cortical contact, utilization of intra-operative imaging and stem subsidence (comparison of initial post-operative radiograph to the latest follow up radiograph - minimum three months) were recorded.

There was no statistically significant difference in the amount of subsidence between the three stems (Monoblock: 2.33mm, Modular A: 3.43mm, Modular B: 3.02mm; p=0.191). There was no statistical difference in subsidence >5mm between stems (Monoblock: 9.9%, Modular A: 22.2%, Modular B: 16.7%). Subgroup analysis based on femoral bone loss grading showed no difference in subsidence between stems. Increased bicortical contact was strongly associated with reduced subsidence (p=0.004). Intra-operative imaging was used in 46.5% (126/271) of cases; this was not correlated with bicortical contact (p=0.673) or subsidence (p=0.521). Across all groups, only two stems were revised for subsidence (0.7%).

All three modern TFT stems were highly successful and associated with low rates of subsidence, regardless of modular or monoblock design. Surgeons should select the stem that they feel is most clinically appropriate.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_14 | Pages 16 - 16
1 Nov 2021
McCalden R Salipas A Teeter M Somerville L Naudie D MacDonald S
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The purpose of this study was to precisely measure the 10-year polyethylene wear rate of primary total hips using Radiostereometric analysis (RSA) comparing Oxidized Zirconium (OxZi) to cobalt chrome (CoCr) femoral heads articulating with highly cross-linked polyethylene (XLPE).

RSA was performed on 46 patients who underwent total hip arthroplasty − 23 who received OxZi femoral heads and 23 who received CoCr heads in combination with XLPE at a minimum of 10 years follow-up. All patients had identical THR systems implanted except for the femoral head utilized. The Centre Index method was utilised to assess total wear rates (from index surgery until final evaluation) using a dedicated RSA Software program (UmRSA Digital Measure v.2.2.1). In addition, the Martell technique was used to subtract head penetration occurring in the first 1–2 years (i.e. bedding-in phase) to allow calculation of the ‘steady state’ wear rates.

There were no significant differences in demographics (i.e age, BMI, gender) between the groups. The average time from surgery of the RSA examinations was 11.7 and 12.6 years for the CoCr and OxZi groups respectively. Using the Centre Index Method to calculate total head penetration, wear rates were slightly higher in the OxZi group (0.048 +/− 0.021mm/year) compared to the CoCr group (0.035 +/− 0.017mm/year) with no statistical difference between the groups (p= 0.02). After correction for the bedding-in period, there was no statistically significant difference in mean ‘steady-state’ wear rate between OxZi (0.031 +/− 0.021mm/year) and CoCr (0.024 +/− 0.019mm/year) at 10 year follow up (p= 0.24). A comparison of preoperative and postoperative SF12, HHS, and WOMAC scores showed no statistical difference between the groups.

RSA demonstrated the 10 year in-vivo wear rates of both bearing combinations to be well below the threshold for osteolysis. There was no significant difference between either the total or ‘steady-state’ wear rates of the OxZi and CoCr groups at 10 years.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_1 | Pages 14 - 14
1 Feb 2021
LaCour M Ta M Callaghan J MacDonald S Komistek R
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Introduction

Current methodologies for designing and validating existing THA systems can be expensive and time-consuming. A validated mathematical model provides an alternative solution with immediate predictions of contact mechanics and an understanding of potential adverse effects. The objective of this study is to demonstrate the value of a validated forward solution mathematical model of the hip that can offer kinematic results similar to fluoroscopy and forces similar to telemetric implants.

Methods

This model is a forward solution dynamic model of the hip that incorporates the muscles at the hip, the hip capsule, and the ability to modify implant position, orientation, and surgical technique. Muscle forces are simulated to drive the motion, and a unique contact detection algorithm allows for virtual implantation of components in any orientation. Patient-specific data was input into the model for a telemetric subject and for a fluoroscopic subject.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 79 - 79
1 Jul 2020
Legault J Beveridge T Johnson M Howard J MacDonald S Lanting B
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With the success of the medial parapatellar approach (MPA) to total knee arthroplasty (TKA), current research is aimed at reducing iatrogenic microneurovascular and soft tissues damage to the knee. In an effort to avoid disruption to the medial structures of the knee, we propose a novel quadriceps-sparing, subvastus lateralis approach (SLA) to TKA. The aim of the present study is to compare if a SLA can provide adequate exposure of the internal compartment of the knee while reducing soft tissue damage, compared to the MPA. Less disruption of these tissues could translate to better patient outcomes, such as reduced post-operative pain, increased range of motion, reduced instances of patellar maltracking or necrosis, and a shorter recovery time.

To determine if adequate exposure could be achieved, the length of the skin incision and perimeter of surgical exposure was compared amongst 22 paired fresh-frozen cadaveric lower limbs (five females/six males) which underwent TKA using the SLA or MPA approach. Additionally, subjective observations which included the percent of visibility of the femoral condyles and tibial plateau, as well as the patellar tracking, were noted in order to qualify adequate exposure. All procedures were conducted by the same surgeon. Subsequently, to determine the extent of soft tissue damage associated with the approaches, an observational assessment of the dynamic and static structures of the knee was performed, in addition to an examination of the microneurovascular structures involved. Dynamic and static structures were assessed by measuring the extent of muscular and ligamentus damage during gross dissection of the internal compartment of the knee. Microneurovascular involvement was evaluated through a microscopic histological examination of the tissue harvested adjacent to the capsular incision.

Comparison of the mean exposure perimeter and length of incision was not significantly different between the SLA and the MPA (p>0.05). In fact, on average, the SLA facilitated a 5 mm larger exposure perimeter to the internal compartment, with an 8 mm smaller incision, compared to the MPA, additional investigation is required to assert the clinical implications of these findings. Preliminary analysis of the total visibility of the femoral condyles were comparable between the SLA and MPA, though the tibial plateau visibility appears slightly reduced in the SLA. Analyses of differences in soft tissue damage are in progress.

Adequate exposure to the internal compartment of the knee can be achieved using an incision of similar length when the SLA to TKA is performed, compared to the standard MPA. Future studies should evaluate the versatility of the SLA through an examination of specimens with a known degree of knee deformity (valgus or varus).


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 71 - 71
1 Jul 2020
Vissa D Lin C Ganapathy S Bryant D Adhikari D MacDonald S Lanting B Vasarhelyi E Howard J
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Dexmedetomidine, an alpha 2 agonist, has been approved for providing sedation in the intensive care unit. Along with sedative properties, it has analgesic activity through its highly selective action on alpha 2 receptors. Recent studies have examined the use of dexmedetomidine as an adjuvant to prolong the duration of peripheral nerve blocks. Studies showing effectiveness of dexmedetomidine for adductor canal block in knee surgery are small. Also, its effectiveness has not been compared to Epinephrine which is a strong alpha and beta receptor agonist. In a previous study, we showed that motor sparing knee blocks significantly increased the duration of analgesia compared with periarticular knee infiltration using local anesthetic mixture containing Epinephrine following total knee arthroplasty (TKA). In this study, we compared two local anesthetic mixtures: one containing Dexmedetomidine and the other Epinephrine for prolongation of motor sparing knee block in primary TKA patients.

After local ethics board approval and gaining Notice of Compliance (NOC) from Health Canada for use of Dexmedetomidine perineurally, 70 patients between the ages 18 – 95 of ASA class I to III undergoing unilateral primary total knee arthroplasty were enrolled. Motor sparing knee block − 1) Adductor canal continuous catheter 2) Single shot Lateral Femoral Cutaneous Nerve block 3) Single shot posterior knee infiltration was performed in all patients using 60 ml mixture of 0.5% Ropivacaine, 10 mg Morphine, 30 mg Ketorolac. Patients randomized into the Dexmedetomidine group (D) received, in addition to the mixture, 1mcg/kg Dexmedetomidine and the Epinephrine (E) group received 200mcg in the mixture. The primary outcome was time to first rescue analgesia as a surrogate for duration of analgesia and secondary outcomes were NRS pain scores up to 24 hours and opioid consumption.

The time to first rescue analgesia was not significantly different between Epinephrine and dexmedetomidine groups, Mean and SD 18.45 ± 12.98 hours vs 16.63 ± 11.80 hours with a mean difference of 1.82 hours (95% CI −4.54 to 8.18 hours) and p value of 0.57. Pain scores at 4, 6, 12, 18 and 24 hours were comparable between groups. Mean NRS pain scores Epinephrine vs Dexmedetomidine groups were 1.03 vs 0.80 at 4 hours, 1.48 vs 3.03 at 6 hours, 3.97 vs 4.93 at 12 hours, 5.31 vs 6.18 and 6.59 v 6.12 at 24 hours. Opioid consumption was also not statistically significant between both groups at 6, 12 18, 24 hours (p values 0.18, 0.88, 0.09, 0.64 respectively).

Dexmedetomidine does not prolong the duration of knee motor sparing blocks when compared to Epinephrine for total knee arthroplasty. Pain scores and opioid consumption was also comparable in both groups. Further studies using higher dose of dexmedetomidine are warranted.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 78 - 78
1 Jul 2020
Somerville L Clout A MacDonald S Naudie D McCalden RW Lanting B
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While Oxidized Zirconium (OxZr) femoral heads matched with highly cross-linked polyethylene (XLPE) have demonstrated the lowest rate of revision compared to other bearing couples in the Australian National Joint Registry, it has been postulated that these results may, in part, be due to the fact that a single company offers this bearing option with a limited combination of femoral and acetabular prostheses. The purpose of this study was to assess clinical and radiographic outcomes in a matched cohort of total hip replacements (THR) utilizing an identical cementless femoral stem and acetabular component with either an Oxidized Zirconium (OxZr) or Cobalt-Chrome (CoCr) femoral heads at a minimum of 10 years follow-up.

We reviewed our institutional database to identify all patients whom underwent a THR with a single cementless femoral stem, acetabular component, XLPE liner and OxZr femoral head with a minimum of 10 years of follow-up. These were then matched to patients who underwent a THR with identical prosthesis combinations with CoCr femoral head by gender, age and BMI. All patients were prospectively evaluated with WOMAC, SF-12 and Harris Hip Score (HHS) preoperatively and postoperatively at 6 weeks, 3 months, 1 and 2 years and every 2 years thereafter. Charts and radiographs were reviewed to determine the revision rates and survivorship (both all cause and aseptic) at 10 years for both cohorts. Paired analysis was performed to determine if differences exist in patient reported outcomes.

There were 208 OxZr THRs identified which were matched with 208 CoCr THRs. There was no difference in average age (OxZr, 54.58 years, CoCr, 54.75 years), gender (OxZr 47.6% female, CoCr 47.6% female), and average body max index (OxZr, 31.36 kg/m2, CoCr, 31.12 kg/m2) between the two cohorts. There were no significant differences preoperatively in any of the outcome scores between the two groups (WOMAC (p=0.449), SF-12 (p=0.379), HHS(p=0.3718)). Both the SF12 (p=0.446) and the WOMAC (p=0.278) were similar between the two groups, however the OxZr THR cohort had slightly better HHS compared to the CoCr THR cohort (92.6 vs. 89.7, p=0.039). With revision for any reason as the end point, there was no significant difference in 10 years survivorship between groups (OxZr 98.5%, CoCr 96.6%, p=0.08). Similarly, aseptic revisions demonstrated comparable survivorship rates at 10 year between the OxZr (99.5%) and CoCr groups (97.6%)(p=0.15).

Both THR cohorts demonstrated outstanding survivorship and improvement in patient reported outcomes. The only difference was a slightly better HHS score for the OxZr cohort which may represent selection bias, where OxZr implants were perhaps implanted in more active patients. Implant survivorship was excellent and not dissimilar for both the OxZr and CoCr groups at 10 years. Therefore, with respect to implant longevity at the end of the first decade, there appears to be no clear advantage of OxZr heads compared to CoCr heads when paired with XLPE for patients with similar demographics. Further follow-up into the second and third decade may be required to demonstrate if a difference does exist.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_8 | Pages 102 - 102
1 May 2019
MacDonald S
Full Access

Metal-on-metal bearings (MoM), in both a total hip and resurfacing application, saw an increase in global utilization in the last decade. This peaked in 2008 in the US, with approximately 35% of bearings being hard-on-hard (metal-on-metal or ceramic-on-ceramic). Beginning in 2008, reports in the orthopaedic literature began to surface regrading local soft tissue reactions and hypersensitivity to metal-on-metal bearings. A major implant manufacturer recalled a resurfacing device in 2010 after national joint registries demonstrated higher than expected revision rates.

Patients with painful metal-on-metal bearings presenting to the orthopaedic surgeon are a difficult diagnostic challenge. The surgeon must go back to basic principles, perform a complete history and physical exam, obtain serial radiographs and basic bloodwork (ESR, CRP) to rule out common causes of pain and determine if the pain is, or is not, related to the bearing.

The Asymptomatic MoM Arthroplasty: Patients will present for either routine followup, or because of concerns regarding their bearing. It is important to emphasise that at this point the vast majority of patients with a MoM bearing are indeed asymptomatic and their bearings are performing well. The surgeon must take into account: a) which specific implant are they dealing with and what is its track record; b) what is the cup position; c) when to perform metal ion testing; d) when to perform further soft tissue imaging (MARS MRI, Ultrasound); e) when to discuss possible surgery. A simple algorithm for both painless and painful MoM Arthroplasties has been developed and will be presented.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_8 | Pages 91 - 91
1 May 2019
MacDonald S
Full Access

At the present time, there is no bearing in total hip arthroplasty that a surgeon can present to a younger and/or more active patient as being the bearing that will necessarily last them a lifetime. This is the driver to offering alternative bearings (crosslinked polyethylene with either a CoCr or ceramic head, resurfacings, and ceramic-on-ceramic) to patients. Each of these bearings has pros and cons, and none has emerged as the clear victor in the ongoing debate.

Ceramic-on-ceramic (CoC) bearings have been available for decades. Earlier generation CoC bearings did encounter problems with rare fractures, however, with a greater understanding and improvement in the material, the fracture incidence has been significantly reduced. However, what has emerged in the past few years is an increasing reporting of significant squeaking. The incidence of squeaking, reported in the literature in various series, has varied from less than 1% to over 20%, depending on the definition used.

The primary reasons that ceramic-on-ceramic is not truly the articulation of choice for younger patients are: 1) There is absolutely no evidence that this bearing has a lower revision rate. Data from the Australian joint registry actually shows that at 15 years it has a significantly increased rate of revision (7.2%) compared with using a highly crosslinked liner with either a ceramic (5.1%) or a CoCr (6.3%) head; 2) This bearing is by far the most costly bearing on the market. In 2017 with significant constraints on health care systems across the globe, this is a significant concern; 3) This bearing has unique complications including squeaking and both liner and head fracturing.

While ceramic-on-ceramic can be considered a viable alternative bearing in total hip arthroplasty, it can be in no way considered the articulation of longevity for the younger patient.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_8 | Pages 38 - 38
1 May 2019
MacDonald S
Full Access

This session will present a series of challenging and complex primary and revision cases to a panel of internationally respected knee arthroplasty experts.

The primary cases will include challenges such as patient selection and setting expectations, exposure, alignment correction and balancing difficulties. In the revision knee arthroplasty scenarios issues such as bone stock loss, fixation challenges, instability and infection management will be discussed.

This will be an interactive case-based session that at its conclusion should leave the attendee with a more thorough approach to these challenging issues.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_11 | Pages 30 - 30
1 Aug 2018
MacDonald S Garach M Lanting B McCalden R Vasarhelyi E Naudie D Howard J
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The infection rate after total joint arthroplasty (TJA) has been shown to be 1–2% in multiple series and registry data. Irrigation, debridement, and polyethylene exchange (IDPE) is a common first line treatment in many cases of acute prosthetic joint infection (PJI). The reinfection rate in open IDPE procedures is variable with studies showing reinfection rates of 10–70% depending on various patient and microbial factors. Our pilot study aimed to determine if the bacterial load in infected total joints was sufficiently reduced by IDPE to allow for the use of post-debridement cultures as an independent marker of procedural success.

46 prosthetic joint infections underwent irrigation and debridement using 6L of normal saline and 3L of a normal saline and bacitracin mixture prior to the insertion of a new polyethylene liner. This protocol utilized a single equipment setup with all surgical members donning new gloves prior to polyethylene exchange. Between 3 and 5 intraoperative cultures were obtained both prior to and after debridement as per the surgeon's standard protocol. A two-tailed student's t-test was used to evaluate for any differences in the rate of positive culture between these two groups.

Of all pre- and post-debridement cultures sampled 66.5% and 60.7% of cultures were positive respectively. No significant difference in the rate of positive intraoperative culture was found between pre-debridement and post-debridement groups (p = 0.52). In 32 of 46 (69%) cases there was no difference in the total number of positive cultures despite a thorough debridement.

Our data shows that open debridement of PJI does not provide a sterile environment, and post-debridement cultures should not be used as an independent marker of procedural success. The role of an irrigation and debridement to reduce the bacterial burden and potentiate the clearance of an infection is established but its efficacy is unclear, and the inability to create a post-debridement sterile environment is a concern.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_11 | Pages 16 - 16
1 Aug 2018
McCalden R Ponnusamy K Marsh J Somerville L MacDonald S Naudie D Lanting B Howard J Vasarhelyi E
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The purpose of this study is to compare 90-day costs and outcomes for primary total hip arthroplasty (THA) patients between a non-obese (BMI 18.5–24.9) versus overweight (25–29.9), obese (30–34.9), severely-obese (35–39.9), morbidly-obese (40–44.9), and super-obese (45+) cohorts.

We conducted a retrospective review of a prospective institutional database of primary THA patients from 2006–2013, including patients with a minimum of three-year follow-up. Thirty-three super-obese patients were identified, and the other five cohorts were randomly selected in a 2:1 ratio (total n = 363). Demographics, 90-day outcomes (costs, reoperations, and readmissions), and outcomes after three years (revisions and change scores for SF12, HHS, and WOMAC) were collected. Costs were determined using unit costs from our institutional administrative data for all in-hospital resource utilization. Comparisons between the non-obese and other groups were made with Kruskal-Wallis tests for non-normal data and chi-square and Fisher's exact test for categorical data.

The 90-day costs in the morbidly-obese ($13,134 ± 7,250 mean ± standard deviation, p <0.01) and super-obese ($15,604 ± 6,783, p <0.01) cohorts were statistically significantly greater than the non-obese cohorts ($10,315 ± 1,848). Only the super-obese cohort had statistically greater 90-day reoperation and readmission rates than the non-obese cohort (18.2% vs 0%, p <0.01 and 21.2% vs 4.5%, p=0.02, respectively). In addition, reoperations and septic revisions after 3 years were greater in the super-obese cohort compared to the non-obese cohort 21.2% vs 3.0% (p = 0.01), and 18.2% vs 1.5% (p= 0.01), respectively. There were no other statistical differences between the other cohorts with the non-obese cohort at 90-days or after 3 years. Improvements in SF12, HHS, and WOMAC were comparable in all cohorts.

The 90-day costs of a primary total hip arthroplasty for morbidly-obese (BMI 40–44.9) and super-obese (BMI>45) are significantly greater than for non-obese patients, yet these patients have comparable improvements in outcome scores. Health care policies, when based purely on the economic impact of health care delivery, may place morbidly-obese and super-obese patients at risk of losing arthroplasty care, thereby denying them access to the comparable quality of life improvements.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 34 - 34
1 Jun 2018
MacDonald S
Full Access

This session will present a series of challenging and complex primary and revision cases to a panel of internationally respected hip arthroplasty experts. The primary cases will include challenges such as hip dysplasia, altered bony anatomy and fixation challenges. In the revision hip arthroplasty scenarios issues such as bone stock loss, leg length discrepancy, instability and infection will be discussed. This will be an interactive case-based session that at its conclusion should leave the attendee with a more thorough approach to these challenging issues.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 60 - 60
1 Jun 2018
MacDonald S
Full Access

Patients with painful metal-on-metal bearings presenting to the orthopaedic surgeon are a difficult diagnostic challenge. The surgeon must go back to basic principles, perform a complete history and physical exam, obtain serial radiographs and basic blood work (ESR, CRP) to rule out common causes of pain and determine if the pain is, or is not, related to the bearing.

The Asymptomatic MoM Arthroplasty: Patients will present for either routine follow up, or because of concerns re: their bearing. It is important to emphasise that at this point the vast majority of patients with a MoM bearing are indeed asymptomatic and their bearings are performing well. The surgeon must take into account: a) which specific implant are they dealing with and what is its track record; b) what is the cup position; c) when to perform metal ion testing; d) when to perform further soft tissue imaging (MARS MRI, Ultrasound); e) when to discuss possible surgery.

Painful MoM THA causes not related to the bearing couple: These can be broken down into two broad categories. Causes that are Extrinsic to the hip include: spine, vascular, metabolic and malignancy. Causes that are Intrinsic to the hip can either be Extracapsular (iliopsoas tendonitis and trochanteric bursitis) or Intracapsular (sepsis, loosening, thigh pain, prosthetic failure)

Painful MoM THA causes related to the bearing couple: There are now described a number of possible clinical scenarios and causes of pain that relate to the metal-on-metal bearing couple itself: a) local hypersensitivity reaction without a significant soft tissue reaction; b) local hypersensitivity reaction with a significant soft tissue reaction; c) impingement and soft tissue pain secondary to large head effect.

Metal ions: obtaining serum, or whole blood, cobalt and chromium levels is recommended as a baseline test. However, there is no established cutoff level to determine with certainty if a patient is having a hypersensitivity reaction. A 7 parts per billion cutoff has been suggested. This gives high specificity, but poor sensitivity. Metal ions therefore can be used as a clue, and one more test in the workup, but cannot be relied upon in isolation to make a diagnosis.

MARS MRI: a useful tool for demonstrating soft tissue involvement, but there are many painless, well-functioning MoM implants that have soft tissue reactions, that don't require a revision. In the painful MoM hip an MRI, or ultrasound, is recommended to look for soft tissue destruction or a fluid-filled periprosthetic lesion (pseudotumor). Significant soft tissue involvement is concerning and is commonly an indication for revision in the painful MoM hip.

Treatment: management of the painful MoM hip is directly related to the etiology of the pain. Unique to MoM bearing is the issue of pain secondary to a local hypersensitivity reaction. All above tests should be utilised to help determine the best course of action in any individual patient. The painful MoM bearing, that is demonstrating significant soft tissue involvement is a concerning scenario. Earlier revision, to prevent massive abductor damage, would seem prudent for these patients. The painful MoM bearing with no significant soft tissue changes can probably be followed and reviewed at regular intervals. If the pain persists and is felt to be secondary to a hypersensitivity reaction, then revision is really the only option, although the patient must be cautioned regarding the unpredictable nature of the pain relief.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 98 - 98
1 Jun 2018
MacDonald S
Full Access

The use of robotics in total joint arthroplasty is the latest in a long list of expensive technologies that promise multiple positive outcomes, but come with an expensive price tag. In the last decade alone we've seen the same claims for navigation and patient specific instruments and implants. There are various current systems available including a robotic arm, robotic-guided cutting jigs and robotic milling systems.

For robotics to be widely adopted it will need to address the following concerns, which as of 2017 it has not.

Cost - Very clearly the robotic units come with a significant price tag. Perhaps over time, like other technologies, they will reduce, but at present they are prohibitive for most institutions.

Outcomes - One could perhaps justify the increased costs if there was compelling evidence that either outcomes were improved or revision rates reduced. Neither of these has been proved in any type of randomised trial or registry captured data.

As with any new technology one must be wary of the claims superseding the results. In 2017 the jury is still out on the cost vs. benefit of robotic-assisted TKA.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 5 - 5
1 Jun 2018
MacDonald S
Full Access

At the present time, there is no bearing in total hip arthroplasty that a surgeon can present to a younger and/or more active patient as being the bearing that will necessarily last them a lifetime. This is the driver to offering alternative bearings (crosslinked polyethylene with either a CoCr or ceramic head, resurfacings, and ceramic-on-ceramic) to patients. Each of these bearings has pros and cons, and none has emerged as the clear victor in the ongoing debate.

Ceramic-on-Ceramic (CoC) bearings have been available for decades. Earlier generation CoC bearings did encounter problems with rare fractures, however, with a greater understanding and improvement in the material, the fracture incidence has been significantly reduced. However, what has emerged in the past few years is an increasing reporting of significant squeaking. The incidence of squeaking, reported in the literature in various series, has varied from less than 1% to over 20%, depending on the definition used.

The primary reasons that Ceramic-on-Ceramic is not truly the articulation of choice for younger patients are:

There is absolutely no evidence that this bearing has a lower revision rate. Data from the Australian joint registry actually shows that at 15 years it has a significantly increased rate of revision (7.2%) compared with using a highly crosslinked liner with either a ceramic (5.1%) or a CoCr (6.3%) head.

This bearing is by far the most costly bearing on the market. In 2017 with significant constraints on health care systems across the globe, this is a significant concern.

This bearing has unique complications including squeaking and both liner and head fracturing.

While Ceramic-on-Ceramic can be considered a viable alternative bearing in total hip arthroplasty, it can be in no way considered the articulation of longevity for the younger patient.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 26 - 26
1 Jan 2018
MacDonald S Howard J Goyal P Yuan X Lanting B Teeter M Naudie D McCalden R
Full Access

Lewinnek's safe zone recommendation to minimise dislocations was a target of 5–25° for anteversion angle and 30–50° for inclination angle. Subsequently, it was demonstrated that mal-positioning of the acetabular cup can also lead to edge loading, liner fracture, and greater conventional polyethylene wear. The purpose of this study was to measure the effect of acetabular cup position on highly crosslinked polyethylene wear in total hip arthroplasty (THA) at long-term follow-up.

We identified all patients that underwent primary THA with a minimum of 10 years follow-up using an institutional database in London, Ontario, Canada. Patients with a single implant design consisting of a 28 mm cobalt chromium head and highly crosslinked polyethylene liner (ram extruded, GUR 1050, 100 kGy gamma irradiated, remelted, ethylene oxide sterilised) were selected for inclusion. In total, 85 hips from 79 recruited patients were analysed. Patients underwent a supine radiostereometric analysis (RSA) exam in which the x-ray sources and detectors were positioned to obtain an anterior-posterior and cross-table lateral radiograph. Acetabular cup anteversion angle, inclination angle, and 3D penetration rate (including wear and creep) were measured from the stereo radiograph pairs.

At a mean follow-up of 13 years (range, 10–17 years) the mean penetration rate was 0.059 mm/year (95% CI: 0.045 to 0.073 mm/year). Mean anteversion angle was 18.2° (range, −14 to 40°) and mean inclination angle was 43.6° (range, 27 to 61°). With respect to the Lewinnek safe zone, 67% hips met the target for anteversion angle, 77% met the target for inclination angle, and 51% met the target for both. There was no correlation between anteversion angle and penetration rate (r = −0.14, p = 0.72) or between inclination angle and penetration rate (r = 0.11, p = 0.35). There was also no difference (p = 0.07) in penetration rate between hips located within the Lewinnek safe zone for both anteversion angle and inclination angle (mean 0.057 mm/year, 95% CI: 0.036 to 0.079 mm/year) and those outside the safe zone (mean 0.062 mm/year, 95% CI: 0.042 to 0.083 mm/year).

Acetabular cup position had no effect on the wear rate of highly crosslinked polyethylene at long-term follow-up. Although care should still be taken to correctly position the acetabular cup for stability, highly crosslinked polyethylene is a forgiving bearing material that can withstand a wide range of cup positions without negatively impacting longevity due to wear.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_15 | Pages 38 - 38
1 Aug 2017
MacDonald S
Full Access

This session will present a series of challenging and complex primary and revision cases to a panel of internationally respected knee arthroplasty experts.

The primary cases will include challenges such as patient selection and setting expectations, exposure, alignment correction and balancing difficulties. In the revision knee arthroplasty scenarios issues such as bone stock loss, fixation challenges, instability, and infection management will be discussed.

This will be an interactive case based session that at its conclusion should leave the attendee with a more thorough approach to these challenging issues.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_15 | Pages 46 - 46
1 Aug 2017
MacDonald S
Full Access

The incidence of major complications following total joint arthroplasty is low, however, surgeons often continue to see patients regularly to monitor outcomes and the performance of the implant. The purpose of this study was to assess the feasibility, effectiveness and cost-effectiveness of a web-based follow-up compared to in-person assessment following primary total hip or total knee arthroplasty. We also determined patient satisfaction and preference for follow-up method.

Patients who were at least 12 months post-operative were randomised to complete either a web-based follow-up or to have their appointment at the clinic, as usual. We excluded patients who had revision surgery, osteolysis, or identified radiographic issues. We report the frequency of web-based patients who had an issue missed by using the web-based follow-up. We recorded travel costs and time associated with each follow-up, and any health care resource use for one year following the assessment. We conducted a cost analysis from the health-care payer (Ontario Ministry of Health and Long-Term Care) and societal perspectives. All costs are presented in 2012 Canadian dollars. We used descriptive statistics to summarise the satisfaction and preference results and compared satisfaction between groups using Pearson's chi-square test.

Two-hundred-twenty-nine patients completed the study (111 usual-care, 118 web-based), with a mean age of 69 years (range, 38 – 86 years). There were no patients who had an issue missed by the web-based follow-up. The cost for the web-based assessment was significantly lower from both the societal perspective (mean difference, −$64; 95% confidence interval, −$79 to −$48; p < 0.01) and the health-care payer perspective (mean difference, −$27; 95% CI, −$29 to −$25; p < 0.01). Ninety-one patients (82.0%) in the usual-care group indicated that they were either extremely or very satisfied with the follow-up process compared with 90 patients (75.6%) in the web-based group (p < 0.01; odds ratio = 3.95; 95% CI = 1.79 to 8.76). Similarly, 92.8% of patients in the usual care group were satisfied with the care they received from their surgeon, compared to 73.9% of patients in the web-based group (p < 0.01, OR = 1.37; 95% CI = 0.73 to 2.57). Forty-four percent of patients preferred the web-based method, 36% preferred the usual method, and 16% had no preference (p = 0.01).

Web-based follow-up is a feasible, clinically effective alternative to in-person clinic assessment, with moderate to high patient satisfaction. A web-based follow-up assessment has lower mean costs per person compared to the usual method of in-person follow-up from both a societal and health-care payer perspective. The web-based assessment may introduce additional efficiency by redirecting limited outpatient resources to those awaiting first consultation, patients who have complications, or those who are further post-operative and may require a revision.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_15 | Pages 90 - 90
1 Aug 2017
MacDonald S
Full Access

Metal-on-metal bearings (MoM) saw an increase in global utilisation in the last decade. This peaked in 2008 in the US, with approximately 35% of bearings being hard-on-hard (metal-on-metal, or ceramic-on-ceramic). Beginning in 2008, reports began to surface regarding local soft tissue reactions and hypersensitivity to MoM bearings. A major implant manufacturer recalled a resurfacing device in 2010 after national joint registries demonstrated higher than expected revision rates. Patients with painful MoM bearings are a difficult diagnostic challenge. The surgeon must go back to basic principles, perform a complete history and physical exam, obtain serial radiographs and basic blood work (ESR, CRP) to rule out common causes of pain and determine if the pain is, or is not, related to the bearing. The Asymptomatic MoM Arthroplasty: Patients will present for either routine follow up, or because of concerns regarding their bearing. It is important to emphasise that at this point the vast majority of patients with a MoM bearing are indeed asymptomatic and their bearings are performing well. The surgeon must take into account: a) which specific implant are they dealing with and what is its track record; b) what is the cup position; c) when to perform metal ion testing; d) when to perform further soft tissue imaging (MARS MRI, Ultrasound); e) when to discuss possible surgery. Painful MoM THA causes not related to the bearing couple: These can be broken down into two broad categories. Causes that are Extrinsic to the hip include spine, vascular, metabolic and malignancy. Causes that are Intrinsic to the hip can either be Extracapsular or Intracapsular. Painful MoM THA causes related to the bearing couple: There are now described a number of possible clinical scenarios and causes of pain that relate to the MoM bearing couple itself: A) Local hypersensitivity reaction without a significant soft tissue reaction; B) Local hypersensitivity reaction with a significant soft tissue reaction; C) Impingement and soft tissue pain secondary to large head effect. Factors related to a hypersensitivity reaction: Some patients, and prostheses, seem to be at a higher risk of developing issues following a MoM bearing, although our understanding of the interplay of these factors is still in evolution: patients at risk include all women and patients with smaller component sizes. Implant factors play a role with some implants having higher wear rates and being more prone to corrosion. Special tests: There is ongoing confusion related to the relative value of the various special tests that patients with a painful MoM undergo. A) Metal Ions - obtaining serum, or whole blood, cobalt and chromium levels is recommended as a baseline test. However, there is no established cutoff level to determine with certainty if a patient is having a hypersensitivity reaction. Metal ions therefore can be used as a clue, but cannot be relied upon in isolation to make a diagnosis. B) MARS MRI - a useful tool for demonstrating soft tissue involvement, but there are many painless, well-functioning MoM implants that have soft tissue reactions, that don't require a revision. In the painful MoM hip an MRI, or ultrasound, is recommended to look for soft tissue destruction or a fluid-filled periprosthetic lesion (pseudotumor). Significant soft tissue involvement is concerning and is commonly an indication for revision in the painful MoM hip. C) CT imaging - can be utilised to help determine cup position and combined anteversion, however, plain radiographs can give a rough estimate of this as well, so routine CT scan evaluations are not currently recommended. The painful MoM bearing, that is demonstrating significant soft tissue involvement is a concerning scenario. Earlier revision, to prevent massive abductor damage, would seem prudent for these patients.

The painful MoM bearing with no significant soft tissue changes can probably be followed and reviewed at regular intervals. If the pain persists and is felt to be secondary to a hypersensitivity reaction, then revision is really the only option, although the patient must be cautioned regarding the unpredictable nature of the pain relief.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_7 | Pages 22 - 22
1 Apr 2017
MacDonald S
Full Access

Metal-on-metal hip resurfacing enjoyed a period of increased global clinical application beginning in the early to mid-2000's. This tapered off quickly, to the point that it is now a niche surgery. One naturally asks the question, why?

The answers are quite simple: 1) There are no clinical benefits when compared with total hip replacements (THA). While many authors have tried valiantly to demonstrate a benefit clinically to performing a resurfacing over a THA, they have simply been unable to convincingly do so. The procedures produce equivalent clinical results. Many claims, such as allowing a patient greater activity levels and return to sports are clearly heavily biased depending on patient selection. The only credible claim to an advantage over THA that can be made regarding resurfacing implants is indeed there is preservation of host bone of the femoral head and neck. However, this retained bone also reduces the femoral head-to-neck ratio compared to a THA and leads to the potential for bone-on-bone impingement that would not be seen if the neck was resected. Additionally the clinician needs to carefully question the true clinical relevance of this preserved bone. One need only think of all of the isolated acetabular component revisions, or polyethylene liner exchanges, that are performed while retaining solidly ingrown femoral components with good preservation of calcar bone years following the index procedure.

2) Resurfacing implants are much more costly than conventional THA implants. In an era of increased cost constraints, parties are willing to pay more only when there is a proven benefit. Resurfacing implants offer no such benefit.

3) There is a well-documented higher revision rate with resurfacing implants over THA.

While the previous claim was that this wasn't seen in younger males, that too has been disproven. The latest data from the Australian Joint Replacement Registry demonstrates the 15-year cumulative percentage revision rates for conventional total hip at 9.7% and resurfacing at 13.3%.

4) There is the significant risk of metal ions and local hypersensitivity secondary to the metal-on-metal bearing. Again, this risk is significantly limited with the use of a THA with a polyethylene insert.

5) There is a significant incidence of femoral neck fractures.

6) The overall femoral component loosening rates are higher than for total hip replacements.

7) There is a clear learning curve with resurfacing implants with most series showing increased complications in the first fifty cases, and depending on a surgeons overall clinical practice, it may be quite a challenge to ever really overcome this learning curve issue.

8) There is difficulty restoring offset and leg length discrepancies in certain cases when trying to utilise a resurfacing implant.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_7 | Pages 34 - 34
1 Apr 2017
MacDonald S
Full Access

This session will present a series of challenging and complex primary and revision cases to a panel of internationally respected hip arthroplasty experts. The primary cases will include challenges such as hip dysplasia, altered bony anatomy and fixation challenges. In the revision hip arthroplasty scenarios issues such as bone stock loss, leg length discrepancy, instability and infection will be discussed. This will be an interactive case-based session that at its conclusion should leave the attendee with a more thorough approach to these challenging issues.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_7 | Pages 76 - 76
1 Apr 2017
MacDonald S
Full Access

While no one would argue the necessary role for the medical management of patients with early knee arthritis, significant controversy remains regarding the ideal treatment for a patient with bone-on-bone osteoarthritis who could equally be treated with a high tibial osteotomy, a uni-compartmental total knee, potentially a patello-femoral replacement if dealing with isolated patello-femoral disease or lastly, a complete total knee replacement. While clearly to date there has not been consensus on this issue, a review of the arguments, both pro and con, should be used as a guide to the surgeon in making this clinical judgment.

1. Patient Satisfaction.- Many ardent supporters of uni-compartmental knee replacements espouse one of the principle benefits of the uni knee as much greater patient satisfaction. Unfortunately, what is never taken into account is the pre-selection bias that occurs in this patient population. Patients with the most minimal amount of arthritis and those with the greatest range of motion are pre-selected to undergo a uni-compartmental knee replacement compared to the more advanced arthritic knee with mal-alignment and more significant pre-operative disability that will undergo a total knee replacement. Additionally the sources of data to draw the conclusions must be carefully analyzed. We must avoid using data from small series with unblinded patients performed by surgeons expert in the technique. Instead registry data, with its broad based applicability, is a much more logical source of information. Of significance, when over 27,000 patients were assessed regarding satisfaction following knee surgery; there was no difference in proportions of satisfied patients whether they had a total knee or a uni-compartmental knee.

2. Implant Longevity - Once again large prospective cohort data in the form of arthroplasty registries strongly favors total knee arthroplasty over uni-compartmental knee arthroplasty. The Swedish Knee Arthroplasty Registry demonstrated higher revision rates with uni's as compared with total knee replacements. In the Australian Joint Replacement Registry the cumulative 13-year percent revision rate for primary total knee replacements is 6.8% and for uni-compartmental knee replacements is 15.5%. Higher failure rates in uni-compartmental knee replacements seen in Australia has correlated to a significant decrease in the number of uni's being performed, which peaked at 15.1% in 2003 and in 2014 has reduced to 4.7%. There is a direct correlation to age, with younger patients having a significantly higher percentage of revision following uni-compartmental knee replacements (25% failure rate at 11 years if less than 55 years old). There is also tremendous variability in the success rate of the uni in the Australian Registry depending on the implant design (5 year cumulative revision rate range 5.0% to 18.9%), which is simply not seen in the total knee replacement population (5 year cumulative revision rate range 1.6% to 7.7%).

While one can perform the philosophical exercise of debating the merits of a total knee versus uni-compartmental knee, the evidence is overwhelming that in the hands of the masses a total knee replacement patient will have equal satisfaction to a uni-compartmental patient, and will enjoy a much lower probability of revision in the short term and in the long term.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_6 | Pages 66 - 66
1 Mar 2017
MacLean C Lanting B Vasarhelyi E Naudie D McAuley J Howard J McCalden R MacDonald S
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Background

The advent of highly cross-linked polyethylene has resulted in improved wear rates and reduced osteolysis with at least intermediate follow-up when compared to conventional polyethylene. However, the role of alternative femoral head bearing materials in decreasing wear is less clear. The purpose of this study was to determine in-vivo polyethylene wear rates across ceramic, Oxinium, and cobalt chrome femoral head articulations.

Methods

A review of our institutional database was performed to identify patients who underwent a total hip arthroplasty using either ceramic or oxidized zirconium (Oxinium) femoral head components on highly cross-linked polyethylene between 2008 and 2011. These patients were then matched on implant type, age, sex and BMI with patients who had a cobalt chrome bearing implant during the same time period. RSA analysis was performed using the center index method to measure femoral head penetration (polyethylene wear). Secondary quality of life outcomes were collected using WOMAC and HHS Scores. Paired analyses were performed to detect differences in wear rate (mm/year) between the cobalt chrome cohorts and their matched ceramic and Oxinium cohorts. Additional independent group comparisons were performed by analysis of variance with the control groups collapsed to determine wear rate differences between all three cohorts.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_4 | Pages 101 - 101
1 Feb 2017
Teeter M Van Citters D MacDonald S Howard J Lanting B
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Background

Fretting corrosion at the junction of the modular head neck interface in total hip arthroplasty is an area of substantial clinical interest. This fretting corrosion has been associated with adverse patient outcomes, including soft tissue damage around the hip joint. A number of implant characteristics have been identified as risk factors. However, much of the literature has been based on metal on metal total hip arthroplasty or subjective scoring of retrieved implants. The purpose of this study was to isolate specific implant variables and assess for material loss in retrieved implants with a metal on polyethylene bearing surface.

Methods

All 28mm and 32 mm femoral heads from a 12/14 mm taper for a single implant design implanted for greater than 2 years were obtained from our institutional implant retrieval laboratory. This included n = 56 of the 28 mm heads (−3: n = 10, +0: n = 24, +4: n = 13, and +8: n = 9), and n = 23 of the 32 mm heads (−3: n = 2, +0: n = 8, +4: n = 1, and +8: n = 6). There were no differences between groups for age, gender, BMI, or implantation time. A coordinate measuring machine was used to acquire axial scans within each head, and the resulting point clouds were analyzed with a custom Matlab program. Maximum linear wear depth (MLWD) was calculated as the maximum difference between the material loss and as-machined surface. Differences in MLWD for head length, head diameter, stem material, and stem offset were determined.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_22 | Pages 34 - 34
1 Dec 2016
MacDonald S
Full Access

This session will present a series of challenging and complex primary and revision cases to a panel of internationally respected hip arthroplasty experts. The primary cases will include challenges such as hip dysplasia, altered bony anatomy and fixation challenges. In the revision hip arthroplasty scenarios issues such as bone stock loss, leg length discrepancy, instability and infection will be discussed. This will be an interactive case-based session that at its conclusion should leave the attendee with a more thorough approach to these challenging issues.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 62 - 62
1 Dec 2016
Matlovich N Lanting B MacDonald S Teeter M Howard J
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The concept of constitutional varus and controversy regarding placing the total knee arthroplasty (TKA) in a neutral versus physiologic alignment in varus osteoarthritic (OA) patients is an important current discussion. However, the physiologic mechanical alignment of a varus OA knee is unknown and the relative contribution of the femur and tibia to the mechanical axis is unknown. The goal of this study was to determine and analyse the physiologic mechanical axis of medial OA knees.

Plain radiographs of the knee and full-leg standing radiographs of 1558 patients were reviewed for inclusion criteria; 313 patients with a non-arthritic knee and a contralateral varus end-stage OA knee were analysed in the coronal plane. The Hip-Knee-Ankle (HKA), Condylar-Hip (CH)(femoral), Condylar-Plateau (CP) (intra-articular) and Plateau-Ankle (PA)(tibial) angles were measured for both the arthritic and non-arthritic/physiologic knee. The relationship and contribution of all angles was analysed for every 2° degrees of progressive varus: from 4° valgus to 8° varus. The proportion of patients with constitutional varus was also determined for the sample population and correlated with increasing HKA.

The mean CH (femoral) angle was valgus in all groups and decreased with progressive varus alignment (p< 0.0001), ranging from 3.8° ± 1.0° with HKA of 2–4° valgus, to 0.1° ± 1.5° with HKA of 6–8° varus. The mean PA (tibial) angle was varus in all groups and decreased from valgus to progressively varus alignment (p p<0.0001), ranging from 0.78° ± 1.4° with HKA 2–4° valgus, to 5.6° ± 1.9° with HKA 6–8° varus. The CP angle showed no difference between all groups (p=0.3). Forty five percent of males and 22% of females with arthritic HKA in varus alignment were found to have constitutional varus.

Correlation of unilateral arthritic knees to the unaffected, physiologic aligned knee using full-leg radiographs indicates that it may be possible to understand the patient's physiologic, pre-arthritic coronal plane alignment. The mechanical axis of physiologic knees in a unilateral varus OA population demonstrates a variable contribution of the femur (CH) and tibia (PA) from overall valgus to varus alignment. In addition, a significant proportion of the sample population possessed constitutional varus. This may provide important information regarding the placement of physiologic TKA's and direct future research questions.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 55 - 55
1 Dec 2016
Lanting B Thoren J Yuan X McCalden R McAuley J MacDonald S Vasarhelyi E Howard J Naudie D Teeter M
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Adequate fixation of implant components is an important goal for all arthroplasty procedures. Aseptic loosening is one of the leading causes of revision surgery in total knee arthroplasty. Radiostereometric analysis (RSA) is an imaging technique to measure implant migration, with established migration thresholds for well-fixed, at risk, and unacceptably migrating components. The purpose of the present study was to examine the long-term fixation of a cemented titanium fixed bearing polished tibial baseplate.

Patients enrolled in a previous two-year prospective trial were recalled at ten years. All patients received a cemented, posterior-stabilised total knee replacement of the same design implanted by one of three surgeons. Of the original 35 patients, 16 were available for long-term follow-up, with one patient lost to follow-up, nine patients deceased, and a further nine patients unwilling to return to the clinic. Each patient underwent RSA imaging in a supine position using a conventional RSA protocol. Migration of the tibial component in all planes as well as maximum total point motion (MTPM) was compared between all time points (baseline, six weeks, three months, six months, one year, two years) up to the ten year follow-up visits. Outcome scores including the Knee Society Score (KSS), WOMAC, SF-12, and UCLA Activity Score were recorded.

At ten years, the mean migrations of the tibial component were less than 0.1 mm and 0.1 degree in all planes relative to the post-operative RSA exam. There was no significant difference in tibial component migration between time points. However, MTPM increased significantly over time (p = 0.002), from 0.23 ± 0.18 mm at six weeks to 0.42 ± 0.20 mm at ten years. At one year, 13 patients had an acceptable MTPM level, three patients had an ‘at risk’ level, and no patient had an ‘unacceptable’ level. No patients were revised at ten years. WOMAC and KSS were significantly improved (p < 0.0001) at the latest follow-up compared to pre-operatively, but there was no difference in SF-12. The median UCLA Activity Score at latest follow-up was six (range, two to eight).

The tibial baseplate demonstrated solid fixation at ten years. No patients had an unacceptable MTPM level at one year and no patients were revised at ten years, supporting the use of RSA to predict long-term loosening risk. The low level of tibial baseplate migration found in the present study correlates to the low rate of revision for this implant as reported in individual studies and in joint replacement registries.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 84 - 84
1 Dec 2016
Nyland M Lanting B Somerville L Vasarhelyi E Naudie D McAuley J McCalden R MacDonald S Howard J
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Infection following total hip arthroplasty (THA) represents a devastating complication and is one of the main causes for revision surgery. This complication may be treated by irrigation and debridement with head and polyethylene exchange (IDHPE) or a two-stage revision (2SR). Previous studies have reported on the eradication success rates but few have reported patient outcome scores. The purpose of this study was to report patient outcome scores for both IDHPE and 2SR and compare these to a non-infected matched cohort. We hypothesised that both cohorts would have worse outcomes than the control group, and that those who failed an initial IDHPE and required a 2SR would have a worse outcome than those treated initially with a 2SR.

A retrospective review identified 137 patients from our institutional arthroplasty database who had an infected primary THA between 1986–2013. We excluded patients with less than one-year follow-up. Mean follow-up was 60 months (12–187 months). A control cohort was identified and matched according to age and Charlton Comorbidity Index (CCI). Harris Hip Scores, Short Form 12 and WOMAC scores were compared between our control group and our infected cohort.

Sixty-eight patients were treated with a 2SR and 69 patients were treated with an IDHPE. There was a 59% success rate in eradicating the infection with an IDHPE. All of the 28 patients who failed an IDHPE later went on to a 2SR. Outcome scores for the 2SR cohort were significantly worse than the non-infected controls (p0.05). There was no difference in outcome scores when comparing our 2SR cohort to our failed IDHPE (p>0.05).

Previous studies have focused on eradication rates. However, it is important to consider patient outcome scores when deciding the best treatment. Infected patients treated with a successful IDHPE had similar outcomes to non-infected patients. Patients that failed IDHPE and went onto 2SR had similar outcomes to those that had a 2SR alone. IDHPE should still be considered in the treatment algorithm of infected THA.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_22 | Pages 74 - 74
1 Dec 2016
MacDonald S
Full Access

While no one would argue the necessary role for the medical management of patients with early knee arthritis, significant controversy remains regarding the ideal treatment for a patient with bone-on-bone osteoarthritis who could equally be treated with a high tibial osteotomy, a uni-compartmental total knee, potentially a patello-femoral replacement if dealing with isolated patello-femoral disease or lastly, a complete total knee replacement. While clearly to date there has not been consensus on this issue, a review of the arguments, both pro and con, should be used as a guide to the surgeon in making this clinical judgment.

Patient Satisfaction: Many ardent supporters of uni-compartmental knee replacements espouse one of the principle benefits of the uni knee as much greater patient satisfaction. Unfortunately, what is never taken into account is the pre-selection bias that occurs in this patient population. Patients with the most minimal amount of arthritis and those with the greatest range of motion are pre-selected to undergo a uni-compartmental knee replacement compared to the more advanced arthritic knee with mal-alignment and more significant preoperative disability that will undergo a total knee replacement. Additionally the sources of data to draw the conclusions must be carefully analyzed. We must avoid using data from small series with unblinded patients performed by surgeons expert in the technique. Instead registry data, with its broad based applicability, is a much more logical source of information. Of significance, when over 27,000 patients were assessed regarding satisfaction following knee surgery; there was no difference in proportions of satisfied patients whether they had a total knee or a uni-compartmental knee.

Implant Longevity: Once again large prospective cohort data in the form of arthroplasty registries strongly favors total knee arthroplasty over uni-compartmental knee arthroplasty. The Swedish Knee Arthroplasty Registry demonstrated higher revision rates with uni's as compared with total knee replacements. In the Australian Joint Replacement Registry the cumulative 13 year percent revision rate for primary total knee replacements is 6.8% and for uni-compartmental knee replacements is 15.5%. Higher failure rates in uni-compartmental knee replacements seen in Australia has correlated to a significant decrease in the number of uni's being performed, which peaked at 15.1% in 2003 and in 2014 has reduced to 4.7%. There is a direct correlation to age, with younger patients having a significantly higher percentage of revision following uni-compartmental knee replacements (25% failure rate at 11 years if less than 55 years old). There is also tremendous variability in the success rate of the uni in the Australian Registry depending on the implant design (5 year cumulative revision rate range 5.0% to 18.9%), which is simply not seen in the total knee replacement population (5 year cumulative revision rate range 1.6% to 7.7%).

While one can perform the philosophical exercise of debating the merits of a total knee versus uni-compartmental knee, the evidence is overwhelming that in the hands of the masses a total knee replacement patient will have equal satisfaction to a uni-compartmental patient, and will enjoy a much lower probability of revision in the short term and in the long term.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_21 | Pages 59 - 59
1 Dec 2016
Sisko Z Teeter M Lanting B Howard J McCalden R Naudie D MacDonald S Vasarhelyi E
Full Access

Previous retrieval studies demonstrate increased tibial baseplate roughness leads to higher polyethylene backside wear in total knee arthroplasty (TKA). Micromotion between the polyethylene backside and tibial baseplate is affected by the locking mechanism design and can further increase backside wear. The purpose of this study was to examine modern locking mechanisms, in the setting of both roughened and polished tibial baseplates, on backside tibial polyethylene wear.

Five TKA models were selected, all with different tibial baseplate and/or locking mechanism designs. Six retrieval tibial polyethylenes from each TKA model were matched based on time in vivo (TIV), age at TKA revision, BMI, gender, number of times revised, and revision reason. Two observers scored each polyethylene backside according to a visual damage score and individual damage modes. Primary outcomes were mean damage score and individual damage modes. Demographics were compared by one-way ANOVA. Damage scores and modes were analysed by the Kruskal-Wallis test and Dunn's multiple comparisons test.

There were no differences among the groups based on TIV (p=0.962), age (p=0.651), BMI (p=0.951), gender, revision number, or reason for revision. There was a significant difference across groups for mean total damage score (p=0.029). The polished tibial design with a partial peripheral capture locking mechanism and anterior constraint demonstrated a significantly lower score compared to one of the roughened tibial designs with a complete peripheral-rim locking mechanism (13.0 vs. 22.1, p=0.018). Otherwise, mean total damage scores were not significant between groups. As far as modes of wear, there were identifiable differences among the groups based on abrasions (p=0.005). The polished design with a tongue-in-groove locking mechanism demonstrated a significantly higher score compared to both groups with roughened tibial baseplates (5.83 vs. 0.83, p=0.024 and 5.83 vs. 0.92, p=0.033). Only the two designs with roughened tibial baseplates demonstrated dimpling (5.67 and 8.67) which was significant when compared against all other groups (p0.99). No other significant differences were identified when examining burnishing, cold flow, scratching, or pitting. No polyethylene components exhibited embedded debris or delamination.

Total damage scores were similar between all groups except when comparing one of the polished TKA design to one of the roughened designs. The other TKA model with a roughened tibial baseplate had similar damage scores to the polished designs, likely due to its updated locking mechanism. Dimpling wear patterns were specific for roughened tibial baseplates while abrasive wear patterns were identified in the design with a tongue-in-groove locking mechanism. Our study showed even in the setting of a roughened tibial baseplate, modern locking mechanisms decrease backside wear similar to that of other current generation TKA designs.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_22 | Pages 118 - 118
1 Dec 2016
MacDonald S
Full Access

The incidence of major complications following total joint arthroplasty is low, however, surgeons often continue to see patients regularly to monitor outcomes and the performance of the implant. The purpose of this study was to assess the feasibility, effectiveness and cost-effectiveness of a web-based follow-up compared to in-person assessment following primary total hip or total knee arthroplasty. We also determined patient satisfaction and preference for follow-up method.

Patients who were at least 12 months postoperative were randomised to complete either a web-based follow-up or to have their appointment at the clinic, as usual. We excluded patients who had revision surgery, osteolysis, or identified radiographic issues. We report the frequency of web-based patients who had an issue missed by using the web-based follow-up. We recorded travel costs and time associated with each follow-up, and any health care resource use for one year following the assessment. We conducted a cost analysis from the health-care payer (Ontario Ministry of Health and Long-Term Care) and societal perspectives. All costs are presented in 2012 Canadian dollars. We used descriptive statistics to summarise the satisfaction and preference results and compared satisfaction between groups using Pearson's chi-square test.

Two hundred-twenty nine patients completed the study (111 usual-care, 118 web-based), with a mean age of 69 years (range, 38–86 years). There were no patients who had an issue missed by the web-based follow-up. The cost for the web-based assessment was significantly lower from both the societal perspective (mean difference, $−64; 95% confidence interval, $−79 to $−48; p < 0.01) and the health-care payer perspective (mean difference, $−27; 95% CI, $−29 to $−25; p < 0.01). Ninety-one patients (82.0%) in the usual-care group indicated that they were either extremely or very satisfied with the follow-up process compared with 90 patients (75.6%) in the web-based group (p < 0.01; odds ratio = 3.95; 95% CI = 1.79 to 8.76). Similarly, 92.8% of patients in the usual care group were satisfied with the care they received from their surgeon, compared to 73.9% of patients in the web-based group (p < 0.01, OR = 1.37; 95% CI = 0.73 to 2.57). Forty-four percent of patients preferred the web-based method, 36% preferred the usual method, and 16% had no preference (p = 0.01).

Web-based follow-up is a feasible, clinically effective alternative to in-person clinic assessment, with moderate to high patient satisfaction. A web-based follow-up assessment has lower mean costs per person compared to the usual method of in-person follow-up from both a societal and health-care payer perspective. The web-based assessment may introduce additional efficiency by redirecting limited outpatient resources to those awaiting first consultation, patients who have complications, or those who are further postoperative and may require a revision.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_22 | Pages 7 - 7
1 Dec 2016
MacDonald S
Full Access

A conceptually new, to the North American market, acetabular design is currently available when performing a total hip arthroplasty – the dual mobility socket. Essentially this is a press-fit acetabular component with a polished surface (either modular or monoblock) that articulates with a large polyethylene head with a 28 mm ball inserted into that polyethylene in a similar fashion to a bipolar design.

Proponents of this design advocate its use to reduce the risk of dislocation, and it is being offered as an alternative to constrained liners and also as a potential prophylactic application in revision and high risk patients.

The concerns regarding this construct include:

Wear - A large polyethylene head articulating against a polished metal surface may have much greater wear than a conventional metal against polyethylene bearing. Hip simulator data has shown this previously. Additionally there are two articulating surfaces, potentially leading to a greater combined wear than one would see with just a singular surface.

Clinical data - At present there are predominately short term published reports on this implant, many from the same centers. There are no control groups with other implants in these same “at risk” patients. There is no registry data to date on this implant.

Patient Population - A difficult question to answer is which patient is at risk for dislocation and if one was going to apply this new technology, which patient would receive it? In the original published series, 26% of patients undergoing THA had this implant. Does the increased risk of wear and osteolysis warrant the use of this implant in a primary setting?

Unique complication - A unique complication has been described labeled intra-prosthetic dislocation. This occurs when the inner femoral ball disassociates from the polyethylene. The incidence has been reported up to 2% in some series. This complication alone equals the current rate of hip instability in a Medicare database with a conventional total hip replacement.

Cost - In our current era of containing health care costs, this implant is offered to most at a significant cost premium to a more conventional total hip construct, without evidence of superiority, or for that matter equivalence at this point.

There are many options available to both manage and to prevent hip instability. Any new implant must show equivalence to current devices on the many fronts of wear, fixation, mid-term results, complications and costs.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_17 | Pages 109 - 109
1 Nov 2016
MacDonald S
Full Access

The incidence of major complications following total joint arthroplasty is low, however, surgeons often continue to see patients regularly to monitor outcomes and the performance of the implant. The purpose of this study was to assess the feasibility, effectiveness and cost-effectiveness of a web-based follow-up compared to in-person assessment following primary total hip or total knee arthroplasty. We also determined patient satisfaction and preference for follow-up method.

Patients who were at least 12 months post-operative were randomised to complete either a web-based follow-up or to have their appointment at the clinic, as usual. We excluded patients who had revision surgery, osteolysis, or identified radiographic issues. We report the frequency of web-based patients who had an issue missed by using the web-based follow-up. We recorded travel costs and time associated with each follow-up, and any health care resource use for one year following the assessment. We conducted a cost analysis from the health-care payer (Ontario Ministry of Health and Long-Term Care) and societal perspectives. All costs are presented in 2012 Canadian dollars. We used descriptive statistics to summarise the satisfaction and preference results and compared satisfaction between groups using Pearson's chi-square test.

Two hundred-twenty nine patients completed the study (111 usual-care, 118 web-based), with a mean age of 69 years (range, 38–86 years). There were no patients who had an issue missed by the web-based follow-up. The cost for the web-based assessment was significantly lower from both the societal perspective (mean difference, $-64; 95% confidence interval, $-79 to $−48; p < 0.01) and the health-care payer perspective (mean difference, $−27; 95% CI, $−29 to $−25; p < 0.01). Ninety-one patients (82.0%) in the usual-care group indicated that they were either extremely or very satisfied with the follow-up process compared with 90 patients (75.6%) in the web-based group (p < 0.01; odds ratio = 3.95; 95% CI = 1.79 to 8.76). Similarly, 92.8% of patients in the usual-care group were satisfied with the care they received from their surgeon, compared to 73.9% of patients in the web-based group (p < 0.01, OR = 1.37; 95% CI = 0.73 to 2.57). Forty-four percent of patients preferred the web-based method, 36% preferred the usual method, and 16% had no preference (p = 0.01).

Web-based follow-up is a feasible, clinically effective alternative to in-person clinic assessment, with moderate to high patient satisfaction. A web-based follow-up assessment has lower mean costs per person compared to the usual method of in-person follow-up from both a societal and health-care payer perspective. The web-based assessment may introduce additional efficiency by redirecting limited outpatient resources to those awaiting first consultation, patients who have complications, or those who are further post-operative and may require a revision.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 59 - 59
1 Nov 2016
Goyal P Yuan X Teeter M McCalden R MacDonald S Vasarhelyi E McAuley J Naudie D Lanting B Howard J
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Studies that have previously examined the relationship between inclination angle and polyethylene wear have shown increased wear of conventional polyethylene with high inclination angles. To date, there have been no long term in vivo studies examining the correlation between cup position and polyethylene wear with highly crosslinked polyethylene.

An institutional arthroplasty database was used to identify patients who had metal-on-highly crosslinked polyethylene primary total hip arthroplasty (THA) using the same component design with a minimum follow up of 10 years ago. A modified RSA examination setup was utilised, recreating standard anteroposterior (AP) and cross-table lateral exams in a single biplane RSA acquisition. Three dimensional head penetration was measured using the centre index method. The same radiographs were used to measure inclination angle and anteversion. Spearman correlation was used to show an association between the parameters of acetabular position and wear rate.

A total of 43 hips were included for analysis in this study. Average follow-up was 12.3 ± 1.2 years. The average linear wear rate was calculated to be 0.066 ± 0.066 mm/year. Inclination angle was not correlated with polyethylene wear rate (p=0.82). Anteversion was also not correlated with polyethylene wear rate (p=0.11). There was no statistical difference between wear rates of hips within Lewinnek's “safe zone” and those outside this “safe zone” (p=0.11). Males had a higher wear rate of 0.094 ± 0.089 mm/year compared to females with a wear rate of 0.046 ± 0.032 mm/year (p=0.045).

At long term follow up of greater than 10 years, highly cross linked polyethylene has very low wear rates. This excellent tribology is independent of acetabular position, but gender did impact wear rates. Due to the low wear rates, follow-up of even longer term is suggested to examine variables affecting wear.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 87 - 87
1 Nov 2016
Matz J Morden D Teeter M McCalden R MacDonald S Vasarhelyi E McAuley J Naudie D Howard J Lanting B
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Complications involving the patellofemoral joint are a source of anterior knee pain, instability, and dysfunction following total knee arthroplasty. “Overstuffing” the patello-femoral joint refers to an increase in the thickness of the patellofemoral joint after a total knee replacement compared to the preoperative thickness. While biomechanical studies have indicated that overstuffing the patellofemoral joint may lead to adverse clinical outcomes, limited clinical evidence exists to support this notion. The purpose of this study is to evaluate the effect of changing the thickness of the patellafemoral joint on functional outcomes following total knee arthroplasty.

Our institutional arthroplasty database was used to identify 1347 patients who underwent a primary total knee arthroplasty between 2006 and 2012 with the same component design. Standard preoperative and postoperative anteroposterior, lateral, and skyline radiographs were collected and measured for patello-femoral overstuffing. These measurements included anterior patellar displacement, anterior femoral offset, and anteroposterior femoral size. These measurements were correlated with patient outcome data using WOMAC, KSS scores, and postoperative range of motion. Multiple linear regression analysis was used to assess the association between stuffing and functional outcomes.

A total of 1031 patients who underwent total knee arthroplasty were included. Increased anterior patellar displacement, a measure of patellofemoral joint thickness, was associated with decreased WOMAC scores (p=0.02). Anterior femoral offset (p=0.210) and anteroposterior femoral size (p=0.091) were not significantly associated with patient functional outcomes. Postoperative range of motion (ROM) was not associated with patellofemoral stuffing (p=0.190).

The current study demonstrated that functional outcomes are adversely affected by patellofemoral overstuffing. Based on these results, caution is encouraged against increasing the thickness of the patellofemoral joint, particularly on the patellar side of the joint.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_17 | Pages 52 - 52
1 Nov 2016
MacDonald S
Full Access

While the vast majority of total knee replacements performed throughout the world employ a modular metal-backed tibial tray, and not an all-polyethylene tray, this issue remains controversial.

Proposed advantages to a metal-backed tray include: a) decreased bending strains, b) reduces compressive stresses in the cement and cancellous bone beneath the baseplate (especially in asymmetric loading), c) distributes load more evenly across the interface

Proposed advantages of an all-polyethylene tray include: a) cost reduction, b) reduced polyethylene thickness with the same amount of bone resection, c) increased tensile stresses at the interface during eccentric loading

The challenge is at present we don't know the >10-year track record of current generation tibial components. This debate centers on the <60-year-old. This is the most difficult patient in total knee arthroplasty with higher revision rates than an older cohort.

It makes sense to use an all-polyethylene tibia if the revision rates turn out to be similar and you don't intend to do a polyethylene exchange in the future. It makes sense to do a modular tray if the results are similar, but there is an intention to do a polyethylene exchange in the future. If either one of these implants choices has a lower cumulative revision rate, then that is the implant of choice at present.

However, we need to understand that at present we don't know if the results of current generation all-polyethylene tibial components will indeed be equal to metal-backed components. The most recent data from the Australian registry suggests that in fact all-polyethylene tibial components have a higher failure rate than metal-backed components when looking at the entire class of design. This would be expected to be even more significant in the younger patient.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 64 - 64
1 Nov 2016
Teeter M Naudie D McCalden R Yuan X MacDonald S
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The philosophy of cemented total hip arthroplasty (THA) femoral components has become polarised. At one extreme are polished, collarless, tapered devices that are expected to subside; at the other extreme are roughened, non-tapered implants with a collar designed not to subside. Radiostereometric analysis (RSA) allows the accurate measurement of implant movement and has been extensively used for measurement of the in vivo migration of implants. The degree of migration as measured by RSA during the first years after surgery has been shown to correlate with the long-term performance of cemented femoral implants. The purpose of this study was to review the two-year RSA results of two different designs of primary cemented THA stems.

Data from two previous prospective RSA trials with two-year follow-up were pooled. The first group included 36 patients who received a Spectron (Smith & Nephew, Memphis, USA) cemented stem. The second group included 13 patients who received an Exeter (Stryker, Mahwah, USA) cemented stem, and 15 patients who received a CPCS (Smith & Nephew, Memphis, USA) cemented stem. All patients underwent RSA examinations shortly post-operation, at 6 weeks, 3 months, 6 months, 1 years, and 2 years. Migration and rotation of the femoral stems was measured at each time point relative to the post-operative exam, and compared between the two groups.

There was no difference in age at surgery (Spectron 78 ± 6 years, Exeter/CPCS 77 ± 5 years, p = 0.43), BMI (Spectron and Exeter/CPCS 28 ± 5 kg/m2, p = 0.92), or percentage of male patients (Spectron 23% male, Exeter/CPCS 21% male) between the implant groups. Subsidence was significantly greater (p < 0.0001) at all time points from three months to two years for the Exeter and CPCS stems (0.94 ± 0.39 mm at two years) compared to the Spectron stem (0.05 ± 0.16 mm at two years). There was no significant difference between the stem types for medial-lateral translation (p = 0.07) or anterior-posterior translation (p = 0.49), or for anterior-posterior tilt (p = 0.15), internal-external rotation (p = 0.89), or varus-valgus rotation (p = 0.05).

Implant material, design, and surface finish are all factors in the long-term performance of cemented femoral hip implants. In this study, both femoral stem designs had a magnitude of sub-sidence that was within the limits of what is considered to be safe with respect to long-term performance. The continuous subsidence of the Exeter and CPCS stems is consistent with previous reports in the literature.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 95 - 95
1 Nov 2016
Howard J Vijayashankar R Sogbein O Ganapathy S Johnston D Bryant D Lanting B Vasarhelyi E MacDonald S
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Pain immediately following total knee arthroplasty (TKA) is often severe and can inhibit patients' rehabilitation. Recently, adductor canal blocks have been shown to provide adequate analgesia and spare quadriceps muscle strength in the early postoperative period. We devised a single injection motor sparing knee block (MSB) by targeting the adductor canal and lateral femoral cutaneous nerve with a posterior knee infiltration under ultrasound. Our primary objective was to evaluate the analgesia duration of the MSB in comparison to a standard periarticular infiltration (PAI) analgesia using patients' first rescue analgesia as the end point. Secondary outcomes measured were quadriceps muscle strength and length of stay.

We randomised 82 patients scheduled for elective TKA to receive either the preoperative MSB (0.5% ropivacaine, 2.5ug/ml epinephrine, 10mg morphine, and 30mg ketorolac) or intraoperative periarticular infiltration (0.3% ropivacaine, 2.5ug/ml epinephrine, 10mg morphine, and 30mg ketorolac). Duration of analgesia, postoperative quadriceps power, and length of stay were evaluated postoperatively.

Analgesic duration was found to be significantly different between groups. The MSB had a mean duration of 18.06 ± 1.68 hours while the PAI group had a mean duration of 9.25 ± 1.68 hours for a mean difference of 8.8 hours (95% CI 3.98 to 13.62), p<0.01. There were no significant differences between groups in quadriceps muscle strength power at 20 minutes (p=0.91) or 6 hours (p=0.66) after block administration. Length of stay was also not significantly different between the groups (p=0.29).

Motor sparing blocks provide longer analgesia than patients receiving periarticular infiltration while not significantly reducing quadriceps muscle strength or increasing length of hospital stay.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 57 - 57
1 Nov 2016
Lanting B Tan S Lau A Teeter M Del Balso C McCalden R MacDonald S Vasarhelyi E McAuley J Naudie D Howard J
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Trunnionosis in modular hip arthroplasty has recently been recognised to be clinically important. Gaining an understanding of how the material interface at the head-trunnion affects the tribology at the modular junctions has current clinical implications as well as an implication on future implant selection and material choice. This matched-cohort study aims to compare tribocorrosion between ceramic and cobalt-chromium trunnions and to investigate other factors that contribute to the difference in tribocorrosion if present.

All hip prostheses retrieved between 1999 and 2015 at one centre were reviewed. Fifty two ceramic heads were retrieved, and these were matched to a cobalt-chromium cohort according to taper design, head size, neck length and implantation time in that order. The two cohorts were similar in male:female ratio (p=0.32) and body mass index (p=0.15) though the ceramic group was younger than the cobalt-chromium group (56.6 (+/−)13.5 years for ceramic group vs 66.3 (+/−14.4) years for cobalt-chromium group; p=0.001). There was no significant difference in the reasons for revision between the two groups (p=0.42). The femoral head trunnions were examined by two independent observers using a previously published 4-point scoring technique. The trunnions were divided into three zones: apex, middle and base. The observers were blinded to clinical and manufacturing data where possible.

Ceramic head trunnions demonstrated a lower median fretting and corrosion score at the base zone (p<0.001), middle zone (p<0.001) and in the combined score (p<0.001). In a subgroup analysis by head size, ceramic heads had a lower fretting and corrosion score at 28mm head diameter (p<0.001). Within the ceramic group, taper design had a significant effect on fretting and corrosion in the apex zone (p=0.04). Taper design also had a similar effect in the cobalt-chromium group in the apex zone (p=0.03). For the ceramic trunnions, the largest effect was contributed by the difference between the 11/13 taper and the 12/14 taper. For the cobalt-chromium trunnions, the largest effect was contributed by the difference between the 5 degree 38′ 37″ taper and type 1 taper.

Ceramic head trunnions showed a significantly lower fretting and corrosion score as compared to cobalt-chromium trunnions. Ceramic heads had a lower score than cobalt-chromium heads at 28mm head diameter. Taper design had an effect on fretting and corrosion within each cohort.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 62 - 62
1 Nov 2016
MacLean C Vasarhelyi E Lanting B Naudie D Somerville L McCalden R McAuley J MacDonald S Howard J Yuan X Teeter M
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The advent of highly cross-linked polyethylene has resulted in improved wear rates and reduced osteolysis with at least intermediate follow-up when compared to conventional polyethylene. However, the role of alternative femoral head bearing materials in decreasing wear is less clear. The purpose of this study was to determine in-vivo polyethylene wear rates across ceramic, Oxinium, and cobalt chrome femoral head articulations.

A review of our institutional database was performed to identify patients who underwent a total hip arthroplasty using either ceramic or oxidised zirconium (Oxinium) femoral head components on highly cross-linked polyethylene between 2008 and 2011. These patients were then matched on implant type, age, sex and BMI with patients who had a cobalt chrome bearing implant during the same time period. RSA analysis was performed using the centre index method to measure femoral head penetration (polyethylene wear). Secondary quality of life outcomes were collected using WOMAC and HHS Scores. Paired analyses were performed to detect differences in wear rate (mm/year) between the cobalt chrome cohorts and their matched ceramic and Oxinium cohorts. Additional independent group comparisons were performed by analysis of variance with the control groups collapsed to determine wear rate differences between all three cohorts.

A total of 68 patients underwent RSA analysis. Fifteen patients with a ceramic femoral head component and 14 patients with an Oxinium femoral head component along with the same number of matched patients with cobalt chrome femoral head component were included in the analysis. The time in vivo for the Oxinium (5.17 +/− 0.96 years), Oxinium matched cohort (5.13 +/− 0.72 years), ceramic (5.15 +/− 0.76 years) and ceramic matched cohort (5.36 +/− 0.63 years) were comparable. The demographics of all bearing surface cohorts were similar. The paired comparison between the Oxinium and cobalt chrome cohorts (0.33 vs. 0.29 mm/year, p=0.284) and ceramic vs cobalt chrome cohorts (0.26 vs. 0.20 mm/year, p=0.137) did not demonstrate a significant difference in wear rate. The independent groups analysis revealed a significantly higher wear rate of Oxinium (0.33 mm/year) compared to cobalt chrome (0.24 mm/year) (p = 0. 038). There were no differences in HHS and WOMAC scores between the Oxinium and cobalt chrome cohorts (HHS: p = 0.71, WOMAC: p=0.08) or the ceramic and cobalt chrome cohorts (HHS: p=0.15, WOMAC: p=023).

This study presents evidence of a greater wear rate (mm/year) of the Oxinium femoral head component compared to a cobalt chrome femoral head component. This difference was not demonstrated in the ceramic femoral head component. Despite this difference, there were no clinical differences as measured by the HHS and WOMAC. Future research should focus on factors that may contribute to the higher wear rate seen in the Oxinium cohort.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 58 - 58
1 Nov 2016
Neely S Berta D Ralley F Lanting B Vasarhelyi E McAuley J McCalden R MacDonald S Naudie D Howard J
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Total joint arthroplasty is commonly associated with post-operative anemia. Blood conservation programs have been developed to optimise patients prior to surgery. Epoetin Alfa (Eprex) or intravenous (IV) iron transfusions are two modalities that can be used pre-operatively to optimise hemoglobin and ferritin levels. There are, however, potential complications and increased costs associated with their use. Oral iron is a less costly option for those undergoing surgery but requires more time to take effect. There are no studies to date that examine the effects of an early screening program utilising oral iron supplementation prior to total joint arthroplasty. The purpose of this study is to evaluate the effect of implementing early pre-operative oral iron supplementation on patients prior total joint arthroplasty.

A retrospective review of patients undergoing total joint arthroplasty was performed using our institution clinical informatics database. We identified all patients seen in pre-admission clinic (PAC) between Jan 1, 2009 and March 31, 2010 representing our control group. We then identified all patients seen in PAC between October 1, 2012 and December 31, 2013. Patients in this cohort received screening blood work when booked for surgery, and oral iron supplementation was given to patients with hemoglobin of less than 135g/L or ferritin less than 100ug/L, thus representing our treatment group. Patients undergoing revision, uni-compartment knee arthroplasty and bilateral arthroplasties were excluded from the study. Pearson Chi-Square tests were used to calculate significance between groups with main outcomes including pre-admission hemoglobin, and pre-operative requirements for Eprex or IV iron.

In our control group, we identified 354 patients (25.6%) with hemoglobin less than 130 g/L at time of pre-admission clinic. In our treatment group, this number dropped significantly to only 16.4% of patients (p<0.005).

Implementation of an early screening program using oral iron supplementation resulted in a decrease in the number of patients with hemoglobin lower than 130 g/L at the time of pre-admission clinic. There was also a significant decrease in the use of Eprex and IV iron pre-operatively in the patients in the early screening program. These results encourage the use of early oral iron supplementation for patients with hemoglobin less than 135 g/L or ferritin less than 100ug/L in order to optimise patients prior to total joint arthroplasty.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_17 | Pages 38 - 38
1 Nov 2016
MacDonald S
Full Access

This session will present a series of challenging and complex primary and revision cases to a panel of internationally respected knee arthroplasty experts.

The primary cases will include challenges such as patient selection and setting expectations, exposure, alignment correction and balancing difficulties. In the revision knee arthroplasty scenarios issues such as bone stock loss, fixation challenges, instability and infection management will be discussed.

This will be an interactive case-based session that at its conclusion should leave the attendee with a more thorough approach to these challenging issues.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_10 | Pages 24 - 24
1 May 2016
Pang H Seah B MacDonald S
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We present a case of multifocal infection involving the left total hip replacement and the right total knee replacement of a patient, further complicated by an infected non-union of a periprosthetic fracture of the right knee. This required the unique simultaneous management of both infection eradication and fracture stabilization in the knee.

Both sites were treated with a 2-stage procedure, including the novel use of a stemmed articulating spacer for the right knee. This spacer was made combining a retrograde humeral nail, coated with antibiotic-impregnated cement, and a pre-formed articulating cement spacer. The patient was able to weight-bear on this spacer. The fracture went on to unite, and a second stage was performed with the use of stemmed prosthesis and augments. She remains infection free 2 years after the second stage operation.

The use of a stemmed articulating knee spacer can facilitate infection eradication and fracture stabilization while preserving some motion and weight-bearing ability in the 2 stage management of an infected periprosthetic fracture of the knee.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 13 - 13
1 Jan 2016
Al-Khateeb H Howard J Naudie D McCalden RW MacDonald S
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Introduction

Total knee arthroplasty (TKA) has proven clinical success with reported longterm survivorship of 92% in the elderly population. Concerns regarding increased loosening rates and potential need for multiple revision surgeries in patients younger than 60 years have traditionally discouraged TKA in younger patients. The purpose of this study was to review the longterm clinical and radiographic results of patients under the age of 45 yrs who underwent a total knee replacement.

Materials and Methods

A retrospective review of our institutional database was performed between January 1996 and December 2004 The criteria for inclusion in the study were as follows: age 45 years or younger at index arthroplasty, cemented condylar prosthesis, and a minimum follow-up of 9 years. A total of 39 consecutive primary cemented condylar knee arthroplasties in patients with end stage arthritis were performed in 36 patients who were 45 years or younger. The median length of followup was 13.6 years. There were 18 men and 21 women. The mean age was 40.6 years (range, 28–44). There were 23 right, 16 left, and 3 bilateral procedures. The mean body mass index was 31.2 kg/m2

Clinical and radiological evaluations were performed before surgery and at 6 weeks, 3 months, 1 year and every 2 years subsequently. Knee scores were calculated using the Knee Society Clinical Rating Scores (KSCRS), SF-12 and WOMAC scores to assess pre, and post-operative function. Postoperative anteroposterior and lateral views were assessed for femoral and tibial component position, alignment, and presence or progression of radiolucent lines at the bone-cement and prosthesis-cement interfaces

Statistical analysis was performed using the 2-sample test or Wilcoxon rank sum test for comparison of continuous variables. Kaplan-Meier analysis of implant survival was performed with failure defined as femoral component revision due to any cause.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 11 - 11
1 Jan 2016
Al-Khateeb H Mahmud T MacDonald S McAuley JP
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Objectives

Porous metal surfaces have been a popular option for acetabular component fixation in total hip arthroplasty (THA). New THA component designs are introduced periodically with the expectation of better wear properties and survivorship. Since its approval for use in 2002 there have been few clinical outcome studies published on the Pinnacle acetabular cup system. We hypothesised that the hemispherical porous coated Pinnacle acetabular cup system with a range of cup options and bearing surfaces would give us predictably good fixation and survivorship at five years post implantation.

Materials and Methods

A total of 1391 Pinnacle acetabular cups (De Puy, a Johnson & Johnson company, Warsaw IN) were implanted between the period March 2003 to August 2011 by four senior surgeons. There were a total of 29 patients requiring revision surgery. Of these revisions, 23 were excluded from the final analysis. Sixteen were for early infection requiring debridement of the hip joint and exchange of the modular liner and femoral head. Five patients sustained femoral peri-prosthetic fractures requiring further surgery with retention of the acetabular component in all cases. Of the remaining 8 revision cases, only 6 had more than two years follow-up. All patients had pre and post-operative Harris hip scores, WOMAC and SF-12 scores. All patients were assessed with serial radiographs immediately post-operatively, 3 months, 1 year, 2 years, every 2 years thereafter. Component migration and revisions (excluding infection and peri-prosthetic fractures) are reported as failures. Post-operative radiographs were evaluated for component migration. Kaplan-Meier survivorship curves were drawn to show survivorship for cup type and bearing type.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 92 - 92
1 Jan 2016
Vandekerckhove P Teeter M Naudie D Howard J MacDonald S Lanting B
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Summary

The effect of polyethylene wear and lift-off between the tibial and femoral components on the mechanical axis was assessed in primary TKA (Total Knee Arthroplasty) based on retrieval data and full leg radiographs.

Introduction

Controversy exist regarding performing a TKA with component placement in physiologic versus neutral alignment. Some literature indicates good survivorship and superior clinical outcome in undercorrected TKA's for varus osteoarthritic knees. However, other literature indicates decreased survivorship and coronal plane alignment is still one of the contributing factors to wear in total knee arthroplasty (TKA). The two determinants of the intra-articular deformity in TKA arepolyethylene wear and lift-off between the tibial and femoral compartment. The goal of this study was to evaluate the impact of wear and lift-off on the mechanical axis in neutral and varus aligned TKA's.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 93 - 93
1 Jan 2016
Vandekerckhove P Teeter M Naudie D Howard J MacDonald S Lanting B
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Introduction

Coronal plane alignment is one of the contributing factors to polyethylene wear in total knee arthroplasty (TKA). The goal of this study was to evaluate the wear and damage patterns of retrieved tibial polyethylene inserts in relationship to the overall mechanical alignment and to the position of the tibial component.

Materials and methods

Based on full-length radiographs, ninety-five polyethylene inserts retrieved from primary TKA's with a minimum time in-vivo of five years were analysed for wear and damage. Four alignment groups were compared: valgus, neutral, mild varus and moderate varus. Varus and valgus positioning of the tibial component was analysed for damage score for the neutral and varus aligned groups.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_13 | Pages 79 - 79
1 Nov 2015
MacDonald S
Full Access

Only a little over a decade ago the vast majority of primary total hip replacements performed in North America, and indeed globally, employed a conventional polyethylene insert, either in a modular version or in a cemented application. Beginning in the early 2000's there was an explosion in technology and options available for the bearing choice in total hip arthroplasty.

Highly crosslinked polyethylene was introduced in 1998, and within a few short years the vast majority of polyethylene inserts performed in North America were manufactured from this material. Globally there was a mixed picture with variable market penetration. Surgeons had seen historically poor results with attempts at “improving” polyethylene in the past and many were hesitant to use this new technology. Many randomised clinical trials have been performed and all have shown to a greater or lesser degree, that indeed the highly crosslinked polyethylene insert has undergone less linear and volumetric wear than its more conventional counterpart. This replicates well the hip simulator data. The challenge, however, is as we approached mid-term results, orthopaedic manufacturers began altering the polyethylene to improve wear and improve mechanical strength. Therefore while 10-year and greater data will ultimately be published, the actual polyethylene in use at that time will be a different material. Additionally, while wear rates are undoubtedly lower, we are still waiting for long-term results of actual osteolytic lesion development and the effect that highly cross-linked polyethylene will have on this clinical scenario. That being said, with over a decade of clinical experience, unquestionably highly crosslinked polyethylene has truly been a revolution in design, essentially eliminating polyethylene wear as an early failure mode.

The question still remains as to the best material for the femoral ball. Essentially two options exist – cobalt chrome and ceramic (Delta). There are theoretically advantages to ceramic heads; however they come at a cost premium: 1.) To date there have been no published reports that demonstrate any improved clinical outcomes with the use of ceramic heads. In fact, the Australian registry demonstrates that the cumulative revision rate is lowest with CoCr heads (at 10 years, 4.3% with CoCr on XLPE and 4.6% with ceramic on XLPE). 2.) Costs continue to be significantly higher for ceramic heads. A price premium of 2–4× higher cost for ceramic over CoCr heads exists in most global markets. 3.) Trunion issues. An emerging concern is corrosion at the head neck junction in THA. Ceramic heads should theoretically have a lower incidence of taper corrosion. To date this is unproven, as is the actual incidence of this as a significant clinical problem.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_13 | Pages 97 - 97
1 Nov 2015
MacDonald S
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This session will present a series of challenging and complex primary and revision cases to a panel of internationally respected hip arthroplasty experts. The primary cases will include challenges such as hip dysplasia, altered bony anatomy and fixation challenges. In the revision hip arthroplasty scenarios issues such as bone stock loss, leg length discrepancy, instability and infection will be discussed. This will be an interactive case based session that at its conclusion should leave the attendee with a more thorough approach to these challenging issues.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_13 | Pages 32 - 32
1 Nov 2015
MacDonald S
Full Access

Obesity is clearly a worldwide epidemic with significant social, health care and economic implications.

A clear association between obesity and the need for both hip and knee replacement surgery has been demonstrated. Specifically the presence of class 3 obesity (BMI > 40) increases the incidence of THA by 8.5 times and the incidence of TKA by 32.7 times, compared with patients of normal weight.

Issues related to TJA in the morbidly obese include:

Outcomes - There is a growing body of evidence to support the premise that patients undergoing either THA or TKA who are morbidly obese derive significant benefit from the surgical intervention. Specifically patient and disease specific outcome measures (WOMAC, SF-12, KSCRS, HSS) demonstrate equal change between pre-operative and post-operative scores in those patients of normal weight compared to the morbidly obese cohort.

Complications - It would appear that the rate of deep infection is increased in the morbidly obese, and that the greater the BMI, the greater the risk of infection. This is important to understand and appreciate pre-operatively as the surgeon discusses the risk/benefit ratio of the operative intervention.

There is little debate that performing total joint arthroplasty in the morbidly obese is technically challenging and that the potential for increased peri-operative morbidity, particularly in the form of infection is present. That being said, the realised benefit to the patient of the surgical intervention is significant, and denying surgery on the basis of obesity alone is not justified.