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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_9 | Pages 18 - 18
1 May 2016
Bruni D Marcacci M Bignozzi S Zaffagnini S Iacono F
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Introduction

Proper alignment (tibial alignment, femoral alignment, and overall anatomic alignment) of the prosthesis during total knee replacement is critical in maximizing implant survival[7] and to reduce polyethylene wear[1]. Poor overall anatomic alignment of a total knee replacement was associated with a 6.9 times greater risk of failure due to tibial collapse, that varus tibial alignment is associated with a 3.2 times greater risk[2] and valgus femoral alignment is associated with a 5.1 times greater risk of failure[7]. To reduce this variability intramedullary (IM) instruments have been widely used, with increased risk of the fat emboli rate to the lungs and brain during TKA[6] and possible increase of blood loss[4, 5]. Or, alternatively, navigation has been used to achieve proper alignment and to reduce morbidity[3]. Recently, for distal femoral resection, inertial sensors have been coupled to extramedullary (EM) instruments to improve TKA surgery in terms of femoral implant alignment, with respect to femoral mechanical axis, and reduced morbidity by avoidance of IM canal violation. The purpose if this study is to compare blood loss and alignment of distal femoral cut in three cohorts of patients: 1 Operated with inertial based cutting guide; 2 Operated with navigation instruments; 3 operated with conventional IM instruments.

Material and methods

From September to November 2014 30 consecutive patients, eligible for TKA, were randomly divided into three cohorts with 10 patients each:x 1 “EM Perseus”, patient operated with EM inertial based instruments (Perseus, Orthokey Italia srl, Florence, Italy); 2 “EM Nav”, operated with standard navigated technique, where bone resections were planned and verified by mean of navigation system (BLUIGS, Orthokey Italia srl, Florence, Italy); 3 “IM Conv”, operated with standard IM instrumentation. All patients were operated by the same surgical technique, implanted TKA were mobile bearing PS models, Gemini (Waldemar Link, Hamburg, Germany) and Attune (Depuy, Warsaw, Indiana). Anteroposterior, lateral, and full-limb weightbearing views preoperatively and postoperatively at discharge were obtained, taking care of neutral limb rotational positioning in all patients enrolled in the study. Angles between femoral mechanical axis and implant orientation on frontal and lateral planes were measured with a CAD software (Rhinoceros 3, McNeel Europe, Rome, Italy) by two independent persons, average value was used for statistical analysis. Haemoglobin values were recorded at three time intervals: the day before surgery, at 24h follow-up and at patients discharge.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 56 - 56
1 May 2016
Bruni D Bragonzoni L Bontempi M Akkawi I Raspugli G Iacono F Marcacci M
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The main purpose of the present study was to determine long-term implant fixation of 15 unicompartmental knee arthroplasty (UKAs) with an all-poly tibial component using Roentgen stereophotogrammetric analysis (RSA) at a mean 10-year follow-up. The secondary purpose was to investigate whether the progressive loss of implant's fixation correlates with a reduction in Knee society score (KSS). Fifteen non-consecutive patients with primary knee osteoarthritis received a UKA with an all-poly tibial component were assessed using KSS scores pre-operatively and post-operatively and RSA on day 2 after surgery, then at 3, 6, and 12 months and yearly thereafter. The mean last follow-up was 10 years. An increase in maximum total point motion (MTPM) values from 6 months to 1 year post-operatively was found respect to post-operative reference. Implants’ displacement values were always 2 mm during the first 6 months, and then, two different trends were noticed in revised and non-revised implants. MTPM increase between 1 and 2 years of follow-up in non-revised UKAs was always 0.2 mm, whereas it was [0.2 mm in revised UKAs. A linear and negative correlation with statistical significance was found between MTPM and both clinical and functional KSS scores (p 0.001). Also in a long-term follow-up evaluation, RSA is an effective tool to predict functional results after an all-poly UKA providing also a relevant predictive value at 1 year follow-up, and this can be very useful for both patients and surgeons.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 57 - 57
1 May 2016
Bruni D Iacono F Bignozzi S Marcacci M
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The main purpose of the present study is to prospectively investigate whether preoperative functional flexion axis in patients with osteoarthritisand varus-alignment changes after total knee arthroplasty and whether a correlation exists both between preoperative functional flexion axis and native limb deformity. A navigated total knee arthroplasty was performed in 108 patients using a specific software to acquire passive joint kinematics before and after implant positioning. The knee was cycled through three passive range of motions, from 0 to 120. Functional flexion axis was computed using the mean helical axis algorithm. The angle between the functional flexion axis and the surgical transepicondylar axis was determined on frontal (aF) and axial (aA) plane. The pre- and postoperative hip-kneeankle angle, related to femur mechanical axis, was determined. Postoperative functional flexion axis was different from preoperative only on frontal plane, while no differences were found on axial plane. No correlation was found between preoperative aA and native limb deformity, while a poor correlation was found in frontal plane, between aF and preoperative hip-knee-ankle angle. Total knee arthroplasty affects functional flexion axis only on frontal plane while has no effect on axial plane. Preoperative functional flexion axis is in a more varus position respect to the transepicondylar axis both in pre- and postoperative conditions. Moreover, the position of the functional axis on frontal plane in preoperative conditions is dependent on native limb alignment, while on axial plane is not dependent on the amount of preoperative varus deformity.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 56 - 56
1 Jan 2016
Bruni D Marko T Gagliardi M Bignozzi S Zaffagnini S Akkawi I Colle F Marcacci M
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Introduction

The purpose of this study was to examine whether three types of mobile-bearing PCL sacrificing TKA could restore the native knee translation and rotation. The primary hypothesis was that there are differences in knee kinematics and laxity between three different cruciate-substituting TKA designs: 1 with post-cam mechanism, 2 post-cam mechanism based on an inter-condylar ‘third condyle’ concept, 3 anterior stabilized with deep-dished highly congruent tibial insert; specifically, showing different femoral external rotation with flexion, different femoral translation with flexion and different laxity under stress test. The secondary hypothesis was that there is different clinical outcome between the three TKA designs at 2 years follow-up.

Methods

We recruited 3 cohorts consisting of 30 patients each divided according 3 different TKA designs. All patients were operated with navigated procedure. During surgery preoperative and postoperative kinematics were recorded, in terms of femoral antero-posterior translation and tibial rotation during knee flexion, as also preoperative and postoperative at 2 years follow-up clinical scores have been acquired.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 57 - 57
1 Jan 2016
Bruni D Gagliardi M Grassi A Raspugli G Akkawi I Marko T Marcacci M
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BACKGROUND

Some papers recently reported conflicting results on implant survivorship in all-poly tibial UKRs. Furthermore, the influence of BMI on this specific implant survivorship remains unclear, since existing reports are often based on small series of non-consecutive patients with different follow up durations, enabling to generate meaningful conclusions.

PURPOSE

To determine the 10-years survival rate of an all-poly tibial UKR in a large series of consecutive patients and to investigate whether a correlation exists between a higher BMI and an increased risk of revision for any reason.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 58 - 58
1 Jan 2016
Bruni D Bragonzoni L Gagliardi M Bontempi M Marko T Patella S Marcacci M
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Background

Roentgen Stereophotogrammetric Analysis (RSA) represents nowadays an excellent solution for high-accuracy fixation measurement of UKAs. To date, to the best of our knowledge, no previous study has investigated long-term micromotions of a UKA using RSA. For this reason, the main purpose of the present study is to determine long-term implant fixation of 15 UKAs with all-poly tibial component using RSA at a mean 10-years follow-up. The secondary purpose was to investigate whether the progressive loss of implant's fixation correlates with a reduction of KSS scores.

Methods

Fifteen non-consecutive patients with primary knee osteoarthritis received a UKA with an all-poly tibial component between January 1995 and April 2003 in the Authors' institution. Pre and post-operative KSS scores were recorded. RSA evaluation was performed on day 2 after surgery, than at 3, 6, and 12 months and yearly thereafter. The patients were evaluated with a mean follow-up of 10 years.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 92 - 92
1 Jan 2016
Colle F Lopomo N Bruni D Gagliardi M Marko T Francesco Iacono Zaffagnini S Marcacci M
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Introduction

Providing proper rotational alignment of femoral component in total knee arthroplasty is mandatory to achieve correct kinematics, good ligament balance and proper patellar tracking. Recently functional references, like the function flexion axis (FFA), have been introduced to achieve this goal. Several studies reported the benefits of using the FFA but highlighted that further analyses are required to better verify the FFA applicability to the general clinical practice. Starting from the hypothesis that the FFA can thoroughly describe knee kinematics but that the joint kinematics itself can be different from flexion to extension movements, the purpose of this study was to analyse which factors could affect the FFA estimation by separately focusing on flexion and extension movements.

Methods

Anatomical acquisitions and passive joint kinematics were acquired on 79 patients undergoing total knee arthroplasty using a commercial navigation system. Knee functional axis was estimated, from three flexion and extension movements separately acquired included in a range between 0° and 120°. For flexion and extension, in both pre- and post-implant conditions, internal-external (IE) rotations was analysed to track any changes in kinematic pattern, whereas differences in FFA estimation were identified by analysing the angle between the FFA itself and the transepicondylar axis (TEA) in axial and frontal plane.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 55 - 55
1 Jan 2016
Bruni D Gagliardi M Marko T Raspugli G Akkawi I Marcacci M
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PURPOSE

Lateral osteoarthritis of the valgus knee is a challenging problem, especially for young and active patients, where prosthetic replacement is not indicated. The purpose of the present study is to evaluate clinically and radiographically 91 patients with valgus knee treated with distal femoral varus osteotomy in mid and long term follow-up.

METHODS

A clinical retrospective evaluation based on IKDC, OXFORD and WOMAC scores of 91 patients at 4 to 10 years of follow-up was performed. Subjective evaluation was based on a VAS for pain self-assessment. Radiographic evaluation was performed by an independent observer of all 91 patients at 2 to 6 years of follow-up. A survival analysis was performed assuming revision for any reason as primary endpoint.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 94 - 94
1 Jan 2016
Colle F Lopomo N Bruni D Francesco Iacono Zaffagnini S Marcacci M
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Introduction

Several methods, based on both functional and anatomical references, have been studied to reach the goal of a proper knee kinematics in total knee arthroplasty (TKA). However, at present, there is still a large debate about which is the most precise and accurate method to achieve the correct rotational implant positioning. One of the main methods already used in TKA to describe the tibiofemoral flexion-extension movement, based on a kinematic technique, thus not influenced by the typical variability related to the identification of anatomical references, is called “functional flexion axis” (FFA) method. The purpose of this study was to determine the repeatability in estimating knee functional flexion axis, thus evaluating the robustness of the method for navigated total knee arthroplasty.

Methods

Passive kinematic and anatomical acquisitions were performed with a commercial navigation system on 87 patients undergoing TKA with primary osteoarthritis. Knee FFA was estimated, before and after implant positioning, from three flexion-extension movements between 0° and 120° (Figure 1). The angle between Functional Flexion Axis and an arbitrary clinical reference, the transepicondylar axis (TEA), was analysed in frontal and axial view (Figure 2). Repeatability Coefficient and Intraclass Correlation Coefficient (ICC) were estimated to analyse the reliability and the agreement in identifying the axis.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 93 - 93
1 Jan 2016
Colle F Lopomo N Bruni D Capozzi M Zaffagnini S Marcacci M
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Introduction

The use of a surgical navigation system has been demonstrated to allow to intraoperatively analyze knee kinematics during total knee arthroplasty (TKA), thus providing the surgeon with a quantitative and reproducible estimation of the knee functional behaviour. Recently severak authors used the computer assisted surgery (CAS) for kinematic evaluations during TKA, in particular to evaluate the achievement of a correct joint biomechanics after the prosthesis implantation. The major concern related to CAS is that the movements are usually passively performed, thence without a real active task performed by the subject. Starting from the hypothesis that the passive kinematics may properly describe the biomechanic behaviour of the knee, the main goal of this work was to intra-operatively compare the active kinematics of the limb, analysing a flexion movement actively performed by the patient, and the passive kinematics, manually performed by the surgeon.

Methods

The anatomical and kinematic acquisitions were performed on 31 patients TKA using a commercial navigation system (BLU-IGS, Orthokey, USA). All the surgeries were performed under local anesthesia, which specifically allowed to acquire the passive and active kinematics including three flexion movements. Both in pre- and post-implant conditions, internal-external (IE) rotations and anterior-posterior (AP) translations were estimated to track any changes in the kinematic pattern.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 3 - 3
1 Jul 2014
Bruni D Iacono F Bignozzi S Colle F Marcacci M
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Background

The optimal reference for rotational positioning of femoral component in total knee replacement (TKR) is debated. Navigation has been suggested for intra-op acquisition of patient's specific kinematics and functional flexion axis (FFA).

Questions/Purposes

To prospectively investigate whether pre-operative FFA in patients with osteoarthritis (OA) and varus alignment changes after TKR and whether a correlation exists between post-op FFA and pre-op alignment.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 245 - 245
1 Dec 2013
Bruni D Iacono F Raspugli G Akkawi I Marcacci M
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Purpose:

Management of unicompartmental knee osteoarthritis (OA) in middle-aged patients is a challenging problem. Recent studies have underlined the efficacy of UKA not just in elderly, but also in middle-aged patients. The primary purpose of the present study was to determine the short to mid-term survivorship of an all-poly tibial UKA in patients under 60 years of age. The secondary purpose was to prospectively evaluate the clinical outcome in this selected group of patients.

METHODS:

Thirty-three consecutive patients under 60 years of age at the time of surgery with isolated medial compartment OA underwent a unilateral medial UKA from 2002 to 2005 and were prospectively followed. A Kaplan-Meyer analysis was performed to determine the 8-years implant survivorship with revision for any reason as endpoint. KSS, WOMAC, Tegner-Lysholm, Tegner and VAS scores were prospectively evaluated at 3 to 6 years follow-up. Weight-bearing radiographs were collected pre-operatively and at 3 to 6 years follow-up to prospectively evaluate femorotibial angle (FTA), tibial plateau angle (TPA) and posterior tibial slope (PTS).


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 247 - 247
1 Dec 2013
Bruni D Bragonzoni L Bontempi M Gagliardi M Akkawi I Marcacci M
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Introdution:

Over the last years research has focused on attempts to achieve better fixation in knee prosthesis by improving cementing techniques and prosthetic designs; thus prosthetic fixation is critical while loosening at the bone-cement interface is still an important matter for the orthopaedic surgeon.

Material and Method:

In the present study, we evaluated in vivo displacement of both total and unicompartimental knee prosthesis implanted on 73 patients by collecting data from RSA associated to the conventional X-rays and clinical follow-ups; we were able to reach only 18 patients (2 males and 16 females) for the actual follow up because of death or other diseases occurred on the other patients over the years (mean age at the time of surgery 68, range 27–83).


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 19 - 19
1 Dec 2013
Bruni D Iacono F Colle F Bignozzi S Marcacci M
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BACKGROUND:

The optimal reference for rotational positioning of femoral component in total knee replacement (TKR) is debated. Navigation has been suggested for intra-op acquisition of patient's specific kinematics and functional flexion axis (FFA).

QUESTIONS/PURPOSES:

To prospectively investigate whether pre-operative FFA in patients with osteoarthritis (OA) and varus alignment changes after TKR and whether a correlation exists between post-op FFA and pre-op alignment.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 246 - 246
1 Dec 2013
Bruni D Bragonzoni L Gagliardi M Bontempi M Marcacci M
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The Rizzoli Orthopaedic Institute has been involved in RSA since 1998. During last 25 years, several investigations have been carried on to evaluate both implant fixation and poliethylene deformation in unicompartmental and total knee replacements. Nevertheless, RSA has also been used to investigate the relative micromotions and the kinematic modifications in cadaveric models of ankles with ligamentous injuries. RSA evaluation has demonstrated that in a particular TKR implant, with mobile half-bearings, the threshold for loosening was 1.3° for rotation about the longitudinal axis and 0.5 mm for medio-lateral translation. Moreover, RSA has revealed cold flow to be concentrated in the posterior region of the medial half-bearing. This has lead to further improvement in polyethilene and implant design. RSA has also demonstrated that in all-poly tibial UKR, poliwear does not impair tibial component fixation and that deformation of the all-poly tibial component is strictly correlated to implant loosening. Moreover, RSA has been used to investigate stress-inducible displacement of the tibial component in all-poly UKRs. It has been demonstrated that rotations around the transverse axis of the knee joint are the most common form of stress-inducible displacement, while stress-induced translations are negligible. Moreover, stress-inducible translational displacement has reached significantly higher values for those patients with unexplained painful UKR, despite no sign of loosening on conventional radiographic and standard supine RSA evaluations.

Further application of RSA has focused on the kinematic evaluation of poliethilene motion pattern modifications throughout a 3 years follow-up period after a mobile-bearing TKR. Patients have been investigated in weight-bearing conditions and results demonstrated that longitudinal rotations and medio-lateral translations tended to increase at last follow-up, while sagittal translations dod not show any significant modification over time.

At present, a new device has been installed at the Istituto Ortopedico Rizzoli. It was specifically designed and made for RSA, static and fluoroscopic. This device can work both in mono- and bi-planar configuration as required by the RSA protocols. Moreover it is able to acquire image stacks in order to study the in-vivo and real time kinematics of a joint. he theoretical biomechanical resolution of a static RSA followup tests is 0.2 mm for translation and 0.3° for rotation. In fluoroscopic configuration the theoretical resolution is 1 mm for translation and 1° for rotations, depending on the used frame rate and on the joint movement speed. A kinematic comparison of different prosthetic designs is currently ongoing, to evaluate different motion patterns under dynamic weight-bearing conditions and to compare them with passive kinematics acquired intra-operatively using a navigation system.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 26 - 26
1 Mar 2013
Bruni D Iacono F Presti ML Raspugli G Sharma B Marcacci M
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INTRODUCTION

The purpose of our work was to evaluate changes in clinical scores, passive knee kinematics and stability after mobile bearing TKA surgery.

MATERIAL AND METHODS

60 patients were treated with a mobile bearing prosthesis (Gemini, Waldemar Link, Hamburg, Germany). PCL was always resected. Inclusion criteria were BMI >30, age range 60–80 yrs. Preoperative KSS, KOOS and SF36 scores were recorded. Surgeries were performed with a navigation system (BLU-IGS, Orthokey Italia, Firenze, Italy) to verify bone cuts, ligament balancing and implant positioning. Kinematic tests were executed to determine: tibial rotation and femoral translation through flexion range. Stability tests were performed using varus-valgus stress in extension and at 30° of flexion and drawer test. Acquisition were perfomed with menisci and cruciate ligaments intact, and repeated after final implant fixation. Clinical scores were recorded at 6 months follow-up.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 140 - 140
1 Mar 2013
Bruni D Iacono F Lo Presti M Raspugli G Sharma B Marcacci M
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INTRODUCTION

The literature suggests a survivorship of unicompartmental knee arthroplasties (UKA) for spontaneous osteonecrosisof the knee range from 93% to 96.7% at 10 to 12 years. However, these data arise from series reporting 23 to 33 patients, jeopardizing meaningful conclusions.

OBJECTIVES

Our purpose is to examine a long term survivorship of UKA's in a larger group of patients with SPONK, along with their subjective, symptomatic and functional outcome; to determine the percentage of failures and the reasons for the same in an attempt to identify relevant indications, contraindications, and technical parameters in treating SPONK with a modern implant design.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 25 - 25
1 Mar 2013
Bruni D Iacono F Presti ML Sharma B Raspugli G Marcacci M
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INTRODUCTION

Conventional surgical exposures are usually inadequate for 2-stage revision knee replacement ofinfected implants. Reduced range of motion, extensor mechanism stiffness, peripatellar contracture and soft tissue scarring make patellar eversion difficult and forced eversion places the integrity of the extensor mechanism at risk. On the contrary, a wide exposure is fundamental to allow complete cement spacer removal, soft tissue balancing, management of bone loss and reimplantation without damaging periarticular soft tissues.

OBJECTIVES

To compare the long-term clinical, functional and radiographic results and the reinfection rate of the quadriceps snip approach and the tibial tubercle osteotomy in 2-stage revision knee replacement performed for septic loosening of the primary implant.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 144 - 144
1 Sep 2012
Bruni D Raspugli G Iacono F Lo Presti M Zaffagnini S Marcacci M
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Background

The reported outcomes of unicompartmental knee replacement (UKR) for spontaneous osteonecrosis of the knee (SPONK) often derive from small series with an average followup of 5 years, enabling to generate meaningful conclusions. Therefore, we determined the long-term functional results and the 10-years survivorship of the implant in all patients with advanced SPONK of the medial tibio-femoral compartment treated with a unicompartmental knee arthroplasty at our institute.

Methods

We retrospectively evaluated 84 consecutive patients with late stage SPONK. All patients received a pre-operative MRI to confirm the diagnosis, to exclude any metaphyseal involvement and to assess the absence of significative degenerative changes in the lateral and PF compartment. Mean age at surgery was 66 years and mean body mass index (BMI) was 28.9. In all cases, SPONK involved the medial compartment; in 77 cases the medial femoral condyle (MFC) was involved, while in 7 cases the pathology site was the medial tibial plateau (MTP). Radiological evaluation was conducted by 3 different radiologists and clinical evaluation according to KSS and WOMAC score was performed by 3 fellows from outside institutions, with no previous clinical contact with the patients, at a mean followup of 98 months.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 375 - 375
1 Sep 2012
Zaffagnini S Marcheggiani Muccioli GM Bonanzinga T Signorelli C Lopomo N Bignozzi S Bruni D Nitri M Bondi A Marcacci M
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INTRODUCTION

This study aimed to intra-operatively quantify the improvements in knee stability given both by anatomic double-bundle (ADB) and single-bundle with additional lateral plasty (SBLP) ACL reconstruction using a navigation system.

MATERIALS AND METHODS

We prospectively included 35 consecutive patients, with an isolated anterior cruciate ligament injury, that underwent both ADB and SBLP ACL reconstruction (15 ADB, 20 SBLP). The testing protocol included anterior/posterior displacement at 30° and 90° of flexion (AP30–AP90), internal/external rotation at 30° and 90° of flexion (IE 30–IE90) and varus/valgus test at 0° and 30° of flexion (VV0–VV30); pivot-shift (PS) test was used to determine dynamic laxity. The tests were manually performed before and after the ACL reconstruction and the data were acquired by means a surgical navigation system (BLU-IGS, Orthokey, USA). Comparisons of pre- and post-reconstruction laxities were made using paired Student t-test (P=0.05) within the same group; comparison between ADB and SBLP groups was indeed performed using independent Student t-test (P=0.05), analysing both starting pre-operative condition and post-operative one.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 140 - 140
1 Sep 2012
Muccioli GMM Zaffagnini S Lopomo N Bruni D Nitri M Bonanzinga T Grassi A Ravazzolo G Molinari M Rimondi E Marcacci M
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Purpouse

We hypothesized that patients receiving a medial collagen meniscus implant (MCMI) would show better clinical, radiograpich and Magnetic Resonanace Imaging (MRI) outcomes than patients treated with partial medial meniscectomy (PMM) at minimum 10 year FU.

Material and Methods

Thirty-three non-randomized patients (males, mean age 40 years) were enrolled in the study to receive a MCMI (17 patients) or as control treated with a PMM (16 patients).

All of them were clinically evaluated at time zero, 5 and minimum 10 years after surgery (mean FU 133 months, range 120–145) by Lysholm, VAS for pain, objective IKDC knee form and Tegner activity level. SF-36 score was performed pre-operatively and at final FU.

Bilateral weight-bearing XRays were executed at time zero and at final FU. Minimum 10 years FU MRI images were compared with collected pre-operative MRI images by means of Yulish score. Genovese score was also used to evalute MCMI MRI survivorship.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 8 | Pages 1060 - 1064
1 Aug 2011
Zaffagnini S Bonanzinga T Muccioli GMM Giordano G Bruni D Bignozzi S Lopomo N Marcacci M

We have shown in a previous study that patients with combined lesions of the anterior cruciate (ACL) and medial collateral ligaments (MCL) had similar anteroposterior (AP) but greater valgus laxity at 30° after reconstruction of the ACL when compared with patients who had undergone reconstruction of an isolated ACL injury. The present study investigated the same cohort of patients after a minimum of three years to evaluate whether the residual valgus laxity led to a poorer clinical outcome.

Each patient had undergone an arthroscopic double-bundle ACL reconstruction using a semitendinosus-gracilis graft. In the combined ACL/MCL injury group, the grade II medial collateral ligament injury was not treated. At follow-up, AP laxity was measured using a KT-2000 arthrometer, while valgus laxity was evaluated with Telos valgus stress radiographs and compared with the uninjured knee. We evaluated clinical outcome scores, muscle girth and time to return to activities for the two groups.

Valgus stress radiographs showed statistically significant greater mean medial joint opening in the reconstructed compared with the uninjured knees (1.7 mm (sd 0.9) versus 0.9 mm (sd 0.7), respectively, p = 0.013), while no statistically significant difference was found between the AP laxity and the other clinical parameters. Our results show that the residual valgus laxity does not affect AP laxity significantly at a minimum follow up of three years, suggesting that no additional surgical procedure is needed for the medial collateral ligament in combined lesions.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 103 - 103
1 May 2011
Giordano G Zaffagnini S Zarbà V Presti ML Nitri M Bruni D Delcogliano M Muccioli GM Marcacci M
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Traumatic anterior shoulder dislocation and sub-luxation are common injuries. But few studies have compared arthroscopic and open stabilization of the shoulder at long-term follow up. The purpose of our study is to show whether an arthroscopic approach to repair Bankart lesion can obtain the same results at long follow up as an open procedure. We analyzed 110 non-randomized consecutive shoulders in 110 patients who underwent a surgical repair of recurrent anterior shoulder instability between 1990 and 1999. Eighty-two patients were available at long term follow up (74,5% retrieval rate). In particular, 49 patients (59.8%) (group A) were treated with arthroscopic transglenoid suture (modified Caspari) between 1990 and 1995 (mean 15,7 year FU), whereas, 33 patients (40.2%) (group B) were treated with open repair between 1995 and 1999 (mean 12,7 year FU). We evaluated the patients in terms of failure rates, Rowe and UCLA scores. The failure cases in the forty-nine patients treated with arthroscopic suture were 13, six dislocations and seven subluxations. The group A had also a Rowe score: function 24.2+8.2, stability 42.4+13.9, range of movement 18.6+3.8, total score 85.0+22.46. The UCLA score was: pain 8.8+1.7, function 8.6+2.1, muscle power 9.2+1.6, total score 26.4+4.8. Of the thirty-three patients treated with open repair, three had at least one post-op dislocations and four felt sometimes subluxations. The Rowe score in group B was: function 23.6+9.7, stability 41.2+14.9, range of movement 18.3+3.9, total score 83.2+24.4. Moreover the UCLA score was: pain 8.8+1.9, function 8.8+1.9, muscle power 9.2+1.2, total score 26.9+4.2. We showed that both techniques were fairly good in treatment of shoulder instability. In our series no significant difference was observed in redislocation rate and in Rowe and UCLA scores between the two groups. The recurrence rate (subluxations and dislocations) was high in both groups: the arthroscopic group had 26.5% and the open one had 21.2%. Our recurrence rate following open repair was higher than in many studies, while the rate after arthroscopic transglenoid procedure was almost equivalent. We hypothesize that one of the reasons for these higher recurrence rates may be the long term follow up. Another cause could be our decision to include subluxation as a failure value, even if there is no agreement about. In fact we believe it to be an important disability factor in sport as in life activities. After surgery, most of the patients returned to their preinjuried activities. But at long term follow up almost all patients have stopped high level sport activity. Moreover, at this long term follow up, some patients told us a feeling of muscle weakness in the last years. In conclusion patients had good impressions about their shoulders thanks to surgery, but also because of lower functional demand.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 502 - 502
1 Oct 2010
Bruni D Giordano G Marcacci M Muccioli GM Russo A Zaffagnini S
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We performed a clinical, instrumental and radiographic study on a highly homogeneous series of 100 consecutive patients with unilateral ACL lesion at 7 years of minimum follow up, alternatively assigned to a single bundle reconstruction using patellar tendon (PT) or to a double bundle reconstruction using hamstrings (DB). Mean Tegner score was 4,8 for PT and 6,5 for DB (p=0,0005). Time for sport resumption was 6,6 months for PT and 3,8 months for DB (p=0,0052). There were no significative differences between the two groups regarding range of motion and functional subjective self-evaluation. Mean anterior displacement at instrumental evaluation performed with KT2000 showed no significative differences between the two groups. Objective clinical evaluation with IKDC was superior for DB group (A=86,5%; B=13,5%) respect to PT group (A=18,7%; B=75%; C=6,3%) (p< 0,0001). We found no differences regarding anterior knee pain between and Ahlback radiographic score the two groups and we have observed no recurrence of instability after surgical treatment. Double bundle ACL reconstruction with hamstrings has showed higher results respect to single bundle ACL reconstruction with patellar tendon in terms of Tegner score, IKDC, time for sport resumption.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 534 - 535
1 Oct 2010
Bruni D Iacono F Marcacci M Muccioli GM Russo A Zaffagnini S
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We performed a retrospective clinical and radiographic evaluation of 100 cases operated in our institute between February 1996 and March 2003 with a mean follow-up of 60 months to assess the efficiency of UKR performed with a new minimally invasive technique. The aim of this study is to correlate the clinical outcome of the patients with the pre- and post-op alignment, and with implant positioning on coronal and sagittal plane.

100 patients (23 ♂, 64 ♀) underwent cemented UKR (De Puy Preservation Uni with all poly tibial component), both for arthritis and osteonecrosis. At the pre-op clinical and radiographic evaluation, 82 patients presented a varus deformity, 5 patients a valgus deformity. The Hospital for Special Surgery Score (HSS) was used to determine the subjective and objective clinical status of the patients before and after the intervention.

Pre-op antero-posterior (AP) x-rays of the knee were executed to establish the femoro-tibial angle (FTA) and the angle between the affected tibial plateau and the tibial anatomical axis (PTA), while latero-lateral (LL) x-rays were performed to determine the posterior tibial slope (PS). To analyze ligamentous balancing, x-rays were performed both in supine and in plain weight bearing stance. Post-op, we performed supine AP e LL X-rays and at a mean follow-up of sixty months (12–84 months) we performed AP and LL plain weight bearing x-rays.

We considered a knee with FTA > 175° as varus knee, 170°< FTA< 175° as normal knee and an FTA < 170° as valgus knee. Moreover, we assumed a TPA > 90° for valgus knee and a TPA< 90° for varus knee.

According with HSS scoring system, at a mean follow-up of 60 months, 63 (76%) cases were excellent (100-85 points), 15 (18%) cases were good (84-70 points), 5 (6%) bad results (< 60 points). Our results demonstrate that patients with a pre-operative varus alignment of 7 degrees are slightly more likely to be selected for UKR. In our series, patients with an excellent clinical result presented pre-operatively a mean varus deformity of 7,9°. According to literature, we demonstrated that a small amount of undercorrection with a residual varus deformity of 3–5° is the goal to be reached in order to avoid both rapid degeneration of the non-replaced compartment as well as the premature loosening of the replaced compartment. We performed a mean axial correction of 5,1° leaving a mean axial varus deformity of 2,8° in the excellent group. In our series the group with excellent results also showed a post-operative PTS of 7,1°, while mean pre-operative PTS was 6,6°. Moreover, the further our radiographic findings were from the optimal position suggested, the worst were the results : a decrease was evident comparing excellent group with good group and this was even more marked comparing excellent group with bad results group.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 540 - 540
1 Oct 2010
Marcacci M Bruni D Di Martino A Giordano G Iacono F Lo Presti M Zaffagnini S
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Arthroscopic selective resurfacing of the knee may be considered a treatment option for selected patients with focal articular damage.

From more than 2 years in IX Division of Rizzoli Orthopaedics Institute(Bologna- Italy) we use, in selected cases with only one articular compartment damaged, an innovative resurfacing prosthesis.

We mad a new design of focal resurfacing (MAIOR) that is possible to implant with arthroscopic technique and that realize both mini-invasive and mini-traumatic surgery.

The fixation method of the MAIOR allows higher osteointegration by biomaterials and hydrossiapatite of new generation that permit a press-fit fixation of the implant.

The new philosophy of this implant consist of early focal treatment with low compromise of bone. Many surgeons, in case of focal articular damage, prefer to attend to made an unique definitive surgical operation when the degenerative changes are more severe.

This new implant permit to substitute, also in arthroscopic technique, only the articular damage and to avoid to attend a more important and diffuse articualr damage.

It is an uncemented, focal resurfacing prosthesis that requires minimal bone sacrifice and utilizes a minimal invasive surgical (MIS) approach with or without arthroscopic assistance.

In a prospective and consecutive study, 78 patients were followed up at least for 12 months. Subjective pain and joint function were assessed using Visual analogue scale (VAS) and Knee society scores respectively. The preliminary results are interesting and encouraging with subjective evaluation equal to 85% of normal knee.

Significant reduction of pain and improvement in joint function was observed. Although, long term study will determine the real performance of the prosthesis, trend seems to be positive.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 267 - 267
1 May 2009
Russo A Bragonzoni L Trozzi C Bruni D Marcacci M
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Aims: Neutral alignment and soft tissue balance are universally accepted as the most important objectives when performing a total knee replacement regardless of the preoperative deformity and implant type. Nevertheless, there is scarce evidence in the scientific literature of the effect of surgical correction on varus/valgus alignment variation during follow-up. We wanted to verify if the femur-tibial alignment after a total knee replacement was maintained at three years’ follow-up, and whether any variation might be correlated to anatomical characteristics before surgery, and to position and fixation of the tibial component within bone.

Methods: We assessed thirty patients with a cemented TKR implant preoperatively, and at one and three years’ follow-up. Lower limb alignment and tibial component position were evaluated manually from antero-posterior radiographs in weight-bearing position. The tibial component varus/valgus migration was measured by Roentgen Stereophotogrammetry.

Results: In spite of the correct alignment obtained during surgery, at 3 years’ follow-up 40% of patients presented an alignment variation of over 3°. The variation of deformity was not correlated with the preoperative deformity, nor with the tibial component position with respect to the tibial shaft nor with its migration.

Conclusions: After total knee arthroplasty, the recurrence of deformity is a common finding in spite of correct alignment obtained during surgery, but it does not influence the clinical result at mid-term follow-up. Anyway the unbalanced forces determining variation in coronal alignment, at a longer follow-up might produce deficiency of soft tissue structures, loosening of the prosthesis component, or polyethylene failure, leading to revision surgery.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 425 - 425
1 Oct 2006
Presti ML Bruni D Zaffagnini S De Pasquale V Reggiani LM Marcacci M
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Purpose: Ultrastructural analysis of PT graft for ACL single bundle reconstruction.

Materials and methods: Arthroscopical biopsies for new meniscal lesions at 6-12-24mm-5-10 ys. All cases with IKDC normal/nearly normal and KT2000 excellent/good.

Samples prepared with Karnowsky fixing and urani-lacetate solution. Fibril diameter and transversal area measured by LEICA QUIN in 5 cuts randomly selected for each sample.

Results: 6 months biopsy showed severe P.T. modifications, with a decrease of larger fibrils, substituted with smaller one with plenty of extra cellular matrix. Oxitalan fibers, macrophagic cells and tenocytes were observed. At 12 months compact fascicles of small fibrils (50–60 nm) divided the larger one, similar to a normal tendon. At 24 months graft modifications were increased with wide compact fasciclesvariously oriented. At 5 and 10 years the modifications were similar to those observed at 2 years, with the graft not completely transformed in native ACL structure.

Discussion: The results showed that PT graft used for ACL single bundle reconstruction certainly undergoes a neoligamentization process up to two years. At longer follow-up the foresaw complete remodelling in a normal ACL was not observed. Heterogeneous fibrils presence suggests incomplete ligamentization or its impossible complete realization in single bundle ACL reconstructions.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 426 - 426
1 Oct 2006
Bruni D Marcacci M Zaffagnini S Presti ML Pereira M
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Purpose: Functional, radiological and instrumental comparison between ACL reconstruction with Single Bundle plus lateral augmentation (SB) versus Double Bundle technique (DB).

Materials and methods: Random choice of 70 patients operated by the same equipe for ACL reconstruction with autologous hamstrings, 35 with SB+lateral augmentation and 35 with DB technique.

Investigation based on: Sport activity recover; IKDC; KT2000; isokinetical tests; muscular throphysm recover; Tegner and Lyshom score; Activity Rating Scale (ARS); Psychovitality Questionnaire; radio graphical evaluation in AP, LL and Rosemberg.

Results: IKDC results superior for DB group, with no bad results and superposable ROM for both groups. Sport activity recover in 100% patients of DB group, with reduced time respect to SB group. Excellent and superposable results for both groups at KT2000. Better muscular throphysm and isocinetic tests results for DB group. Ahlback score same to pre-op in both groups. ARS and Psychovitality questionnaire results better for DB group.

Discussion: Both surgical techniques guarantee excellent results.

DB technique allows a faster sport activity and muscular throphysm recover and better results in the isoci-netical tests.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 426 - 426
1 Oct 2006
Zaffagnini S Bignozzi S Martelli S Imakiire N Bruni D Marcacci M
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The kinematic effect of tunnel orientation and position, during ACL reconstruction, has been only recently related to the control of rotational instability.

This paper presents a detailed computer-assisted in vitro evaluation of two different femoral tunnel orientations with the same tunnel position, at 10.30 ‘o clock, during the intervention of ACL reconstruction with double bundle technique. Results highlighted better kinematic performances of the horizontal tunnel, with respect to the vertical one, in controlling antero-posterior (AP) laxities at 30°, and internal-external (IE) laxities.

Elongations of anterior and posterior bundles of reconstructed ACL, for both reconstruction, decreased during PROM respectively by 20% and 40%. Total length of the graft varied during PROM, mainly due to graft elongation during tests, graft length on horizontal tunnel varied from 237 to 213mm while graft length on vertical tunnel varied from 257 to 233mm. Kinematic tests showed a better performance of horizontal tunnel in the control of IE rotations at 30° and 90° and of the Lachman test with respect to the vertical one. Stability was restored with both reconstructions.