The study aimed to assess the clinical outcomes of arthroscopic debridement and partial excision in patients with traumatic central tears of the triangular fibrocartilage complex (TFCC), and to identify prognostic factors associated with unfavourable clinical outcomes. A retrospective analysis was conducted on patients arthroscopically diagnosed with Palmer 1 A lesions who underwent arthroscopic debridement and partial excision from March 2009 to February 2021, with a minimum follow-up of 24 months. Patients were assessed using the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, Mayo Wrist Score (MWS), and visual analogue scale (VAS) for pain. The poor outcome group was defined as patients whose preoperative and last follow-up clinical score difference was less than the minimal clinically important difference of the DASH score (10.83). Baseline characteristics, arthroscopic findings, and radiological factors (ulnar variance, MRI, or arthrography) were evaluated to predict poor clinical outcomes.Aims
Methods
Osteoarthritis (OA) of the equine distal interphalangeal joint (DIPJ) is a common cause of lameness. MicroRNAs (miRNAs) from biofluids such as plasma and synovial fluid make promising biomarker and therapeutic candidates. The objectives of this study are (1) Identify differentially expressed (DE) miRNAs in mild and severe equine DIPJ OA synovial fluid samples and (2) Determine the effects of DE miRNAs on equine chondrocytes in monolayer culture. Synovial fluid samples from five horses with mild and twelve horses with severe DIPJ OA were submitted for RNA-sequencing; OA diagnosis was made from MRI T2 mapping, macroscopic and histological evaluation. Transfection of equine chondrocytes (n=3) was performed using the Lipofectamine® RNAiMAX system with a negative control and a miR-92a mimic and inhibitor. qPCR was used to quantify target mRNA genes. RNA-seq showed two miRNAs (miR-16 and miR-92a) were significantly DE (p<0.05). Ingenuity Pathway Analysis (IPA) identified important downstream targets of miR-92a involved in the pathogenesis of osteoarthritis and so this miRNA was used to transfect equine chondrocytes from three donor horses diagnosed with OA. Transfection was successfully demonstrated by a 1000-20000 fold increase in miR-92a expression in the equine chondrocytes. There was a significant (p<0.05) increase in COMP, COL3A1 and Sox9 in the miR-92a mimic treatment and there was no difference in ADAMTS-5 expression between the miR-92 mimic and inhibitor treatment. RNA-seq demonstrated miR-92a was downregulated in severe OA synovial fluid samples which has not previously been reported in horses, however miR-92a is known to play a role in the pathogenesis of OA in other species. Over expression of miR-92a in equine chondrocytes led to significantly increased COMP and Sox9 expression, consistent with a chondrogenic phenotype which has been identified in human and murine chondrocytes.
Dysmorphic pelves are a known risk factor for malpositioned iliosacral screws. Improved understanding of pelvic morphology will minimise the risk of screw misplacement, neurovascular injuries and failed fixation. Existing classifications for sacral anatomy are complex and impractical for clinical use. We propose a CT-based classification using variations in pelvic anatomy to predict the availability of transosseous corridors across the sacrum. The classification aims to refine surgical planning which may reduce the risk of surgical complications. The authors postulated 4 types of pelves. The “superior most point of the sacroiliac joint” (sSIJ) typically corresponds with the mid-lower half of the L5 vertebral body. Hence, “the anterior cortex of L5” (L5a) was divided to reference 3 distinct pelvic groups. A 4th group is required to represent pelves with a lumbosacral transitional vertebra. The proposed classification: A – sSIJ is above the midpoint of L5a B – sSIJ is between the midpoint and the lowest point of L5a C – sSIJ is below the lowest point of L5a D – pelves with a lumbosacral transitional vertebra Specific measures such as the width of the S1 and S2 axial and coronal corridors and the S1 lateral mass angles were used to differentiate between pelvic types. Three-hundred pelvic CT scans were classified into their respective types. Analysis of the specific measures mentioned above illustrated the significant difference between each pelvic type. Changes in the size of S1 and S2 axial corridors formed a pattern that was unique for each pelvic type. The intra- and inter-observer ratings were 0.97 and 0.95 respectively. Distinct relationships between the sizes of S1 and S2 axial corridors informed our recommendations on trans-sacral or iliosacral fixation, number and orientation of screws for each pelvic type. This classification utilises variations in the posterior pelvic ring to offer a planning guide for the insertion of iliosacral screws.
There are concerns regarding nail/medullary canal mismatch and initial stability after cephalomedullary nailing in unstable pertrochanteric fractures. This study aimed to investigate the effect of an additional anteroposterior blocking screw on fixation stability in unstable pertrochanteric fracture models with a nail/medullary canal mismatch after short cephalomedullary nail (CMN) fixation. Eight finite element models (FEMs), comprising four different femoral diameters, with and without blocking screws, were constructed, and unstable intertrochanteric fractures fixed with short CMNs were reproduced in all FEMs. Micromotions of distal shaft fragment related to proximal fragment, and stress concentrations at the nail construct were measured.Aims
Methods
Heterotopic ossification is the formation of extraskeletal mineralized tissue commonly associated with either trauma or surgery. While several mouse models have been developed to better characterize the pathologic progression of HO, no model currently exists to study HO of the hip, the most common location of acquired HO in patients. Owing to the unique biological mechanisms underpinning the formation of HO in different tissues, we sought to develop a model to study the post-surgical HO of the hip. Wild-type mice C57BL/6J mice were used to study the procedure outcomes, while Pdgfra-CreERT2;mT/mG and Scx-GFP reporter animals were used for the lineage tracing experiments (total n=16 animals, male, 12 weeks old). An anterolateral approach to the hip was performed. Briefly, a 2 cm incision was made centered on the great trochanter and directed proximal to the iliac crest and distally over the lateral shaft of the femur. The joint was then reached following the intermuscular plane between the rectus femoris and gluteus medius muscles. After the joint was exposed, the articular cartilage was removed using a micropower drill with a 1.2 mm reamer. The medius gluteus and superficial fascia were then re-approximated with Vicryl 5-0 suture (Ethicon Inc, Somerville, NJ) and skin was then closed with Ethilon 5-0 suture (Ethicon Inc). Live high resolution XR imaging was performed every 2 wks to assess the skeletal tissues (Faxitron Bioptics, Tucson, AZ). The images were then scored using the Brooker classification. Ex-vivo microCT was conducted using a Skyscan 1275 scanner (Bruker-MicroCT, Kontich, Belgium). 3D reconstruction and analysis was performed using Dragonfly (ORS Inc., Montreal, Canada). For the histological analysis of specimens, Hematoxylin and Eosin (H&E), modified Goldner's Trichrome (GMT) stainings were performed. Reporter activity was assessed using fluorescent imaging.Introduction and Objective
Materials and Methods
There are concerns regarding initial stability and early periprosthetic fractures in cementless hip arthroplasty using short stems. This study aimed to investigate stress on the cortical bone around the stem and micromotions between the stem and cortical bone according to femoral stem length and positioning. In total, 12 femoral finite element models (FEMs) were constructed and tested in walking and stair-climbing. Femoral stems of three different lengths and two different positions were simulated, assuming press-fit fixation within each FEM. Stress on the cortical bone and micromotions between the stem and bone were measured in each condition.Aims
Methods
The hypothesis of this study was that bone peg fixation in the treatment of osteochondral lesions of the talus would show satisfactory clinical and radiological results, without complications. Between September 2014 and July 2017, 25 patients with symptomatic osteochondritis of the talus and an osteochondral fragment, who were treated using bone peg fixation, were analyzed retrospectively. All were available for complete follow-up at a mean 22 of months (12 to 35). There were 15 males and ten females with a mean age of 19.6 years (11 to 34). The clinical results were evaluated using a visual analogue scale (VAS) and the American Orthopaedic Foot and Ankle Society (AOFAS) score preoperatively and at the final follow-up. The radiological results were evaluated using classification described by Hepple et al based on the MRI findings, the location of the lesion, the size of the osteochondral fragment, and the postoperative healing of the lesion.Aims
Methods
Blood loss after TKA varied, but not uncommon with up to 1500 ml or a decrease in hemoglobin of 3–4 g/dL. In addition to improving prosthetic alignment, computer-assisted TKAs also contribute to reduced operative blood loss and systemic emboli. These observations imply that navigation TKAs may cause less microvascular endothelial damage than conventional TKAs. Cell adhesion molecules (CAMs) have been employed as markers for endothelial or vascular damage. We hypothesized serum levels of CAMs in patients receiving navigation TKAs may be different from those receiving conventional TKAs. A prospective comparative study, enrolling 87 patients with osteoarthritic knees was conducted. There were 54 navigation TKAs and 33 conventional TKAs. Levels of cell adhesion molecules (CAM) in sera and hemovac drainage were measured by ELISA before and 24 hours after the surgery. Hb and Ht were checked pre- and post-operatively. The blood loss was calculated though the formula by Nadler and Sehat et al.Introduction
Material and Methods
A stem sitting proud (SP) or that above the final rasp position remains in some patients who undergo hip replacement using proximally coated tapered wedge stems. Surgeons may face challenges providing the best fit due to unpredictable stem seating. Zimmer Inc. introduced a new rasp to solve this issue but the clinical results of this rasp have not yet been published. Therefore, we aimed to address the following: 1) What is SP incidence using a proximally coated cementless tapered wedge stem? 2) Does the new rasp system improve seating height? 3) What are the risk factors of SP? We performed a retrospective study with 338 hips, in which Tri-Lock Bone Preservation Stem (BPS) was used in 181 and M/L Taper stem was used in 157 hips (82 hips before and 75 hips after the new rasp). A positive stem SP was defined as a stem proud height of >2 mm. We analyzed and compared SP incidence in two stems and in M/L Taper stems before and after the new rasp use.Background
Methods
Cobalt chrome femoral head has been used widely in total hip arthroplasty and has shown favorable outcome. However, there is still of concern of potential metal toxicity from the wear debris. In the other hand, titanium is well known for its biocompatibility but it is not used in bearing surface of arthroplasty due to its brittleness. Recently, coating of the prosthesis using plasma electrolytic oxidation (PEO) has shown favorable surface protection. Thus, in this study, we tried to find out whether the PEO coating on the titanium surface would provide surface protection. Five Titanium alloy (Ti-6Al-4V) ball mimicking femoral head was manufactured and was coted using plasma electrolytic oxidation. Wear rate was tested using validated wear tester with 10N compression force at 80rpm. The amount of wear was detected by measuring change of weight after wear test was completed. This was compared with femoral head manufactured with titanium alloy without PEO coating. Toxicity of the debris was also tested using MTT assay with human osteoblast cell line.Introduction
Materials and methods
The correct anteversion of the acetabular cup is critical to achieve optimal outcome after total hip arthroplasty. While number of method has been described to measure the anteversion in plane anteroposterior and lateral radiograph, it is still controversial which method provides best anteversion measurement. While many of the previous studies used CT scan to validate the anteversion measured in plane anteroposterior radiograph, this may cause potential bias as the anteversion measured in CT scan reflects true anteversion while the anteversion measurement methods in plane radiograph are design to measure the planar anteversion. Thus, in the current study, we tried to find the optimal anteversion measurement method free from the previously described bias. Custom made cup model was developed which enables change in anteversion and inclination. Simple radiograph was taken with the cup in 10° to 70° degree of inclination at 10° increments and for each inclination angle, anteversion was corrected from 0° to 30° at 5° increments. The radiograph was taken with the beam directed at the center of the cup (mimicking hip centered anteroposterior radiograph) and at 9cm medial to the cup (mimicking pelvis anteroposterior radiograph). The measurements were done by two orthopaedic surgeons using methods described by 1) Pradhan et al, 2) Lewinak et al, 3) Widmer et al, and 4) Liaw et al. For each measurements, the anteversion were compared with the actual anteversion.Introduction
Material and method
Clinical and radiological results of total hip arthroplasty (THA) using proximally coated single wedge (PSW) cementless stems are generally excellent. The geometry of cementless stems and the morphology of proximal femurs (Dorr types) provide optimal fit for primary stability and secondary biologic fixation. Because the geometry of PSW shape is designed to be engaged at the metaphysis, cementless PSW stem is not traditionally recommended to Dorr type C femurs with concerns of inadequate implant-host bone contact and the risk of femoral fracture. Nevertheless, previous studies on PSW cementless stems have not examined long-term survivorship according to Dorr types of femur. Paucity of a long-term comparative study makes it difficult to know whether the PSW stem plays a role in Dorr type C femurs or not. We postulated that the PSW stem could achieve stable fixation without increased risk of femoral fracture even in Dorr type C femurs, and demonstrate acceptable long-term results. The aim of this study was to investigate differences of clinical and radiological outcomes of THA using PSW stem according to proximal femoral geometry (Dorr types) in more than a 10-year follow-up. Three hundred and seven primary THA in 247 patients, which was performed with use of a single-designed PSW stem from 1997 to 2003 and was followed up for over 10 years, were included in this retrospective study. According to Dorr's criteria, 89 femora were classified as Type A, 156 as Type B, and 62 as Type C. The patients' mean age at operation was 43.2 years (range, 18.4 – 69.6 years). They were followed-up for an average of 13.2 years (the range, 10.0 – 17.3 years). All of the hips were evaluated clinically and radiologically with special attention to the occurrence of implant loosening and periprosthetic femoral fracture. The mean preoperative Harris hip score (50.4±20.6 points) improved significantly to 95.6±9.0 points at the final follow-ups. The improvements were observed regardless of Dorr types (p<0.001 in all 3 groups). The incidence of thigh pain (p=0.704) was not significantly different among groups. Implant survivorship was 100% in all 3 groups. None of the stems were loosened or revised. No significant differences were observed in osteolysis (p=0.492), pedestal formation (p=0.323), or cortical hypertrophy (p=0.169) among the groups [Fig. 1]. Radiolucent lines less than 2mm in thickness in Gruen zone 4 were observed more in Dorr type C femora than in Dorr type A or B (p=0.003) [Fig. 2]. Spot weld (p<0.001) and stress shielding (p=0.010) of proximal femur were more pronounced in Dorr C type femora than in type A or B [Fig. 3]. The prevalence of intraoperative (p=0.550) or postoperative (p=0.600) femoral fractures were not significantly different among the groups. From over a 10-year follow-up, the PSW stem provided excellent stem survivorship regardless of Dorr type with satisfactory outcomes. The remodeling process around the stem was more pronounced in Dorr type C femur. The present study shows that the PSW stem is a recommendable option for Dorr type C femur.
Alternative bearing surfaces has been introduced to reduce wear debris-induced osteolysis after total hip arthroplasty (THA) and offered favorable results. Large population-based data for total joint surgery permit timely recognition of adverse results and prediction of events in the future. The purpose of this study was to present the epidemiology and national trends of bearing surface usage in primary total hip arthroplasty (THA) in Korea using nationwide database. A total of 30,881 THAs were analyzed using the Korean Health Insurance Review and Assessment Service database for 2007 through 2011. Bearing surfaces were sub-grouped according to device code for national health insurance claims and consisted of ceramic-on-ceramic (CoC), metal-on-polyethylene (MoP), ceramic-on-polyethylene (CoP), and metal-on-metal (MoM). The prevalence of each type of bearing surface was calculated and stratified by age, gender, hospital type, primary payer, and procedure volume of each hospital. The number of primary THAs increased by 25.2% from 5,484 in 2007 to 6,866 in 2011. The average age of the entire study population was 58.1 years, and 53.5% were male [Table 1]. CoC was the most commonly used bearing surface (76.7%), followed by MoP (11.9%), CoP (7.3%), and MoM (4.1%). The distribution of bearing surfaces was identical to that in the general population regardless of age, gender, hospital type, and primary payer [Table 2]. The mean age of patients that received hard-on-hard bearing surfaces (CoC and MoM) was significantly younger than that of patients receiving hard-on-soft bearing surfaces (CoP and MoP) (56.9 years vs. 62.6 years). During the study period, 55.1% of THAs that used a hard-on-hard bearing surface were performed in males, while 53.0% of THAs that used a hard-on-soft bearing surface were performed in females. The order of prevalence of bearing surfaces was identical in low- and medium-volume hospitals (CoC was first, MoP was second, CoP was third, and MoM was fourth). The mean hospital charges did not differ according to the bearing surface used, with the exception of CoP, which was associated with a lower mean hospital charge. There were no changes in the distribution of bearing surfaces in each year between 2007 and 2011. Overall, the percentage of THAs that used CoC bearing surfaces increased substantially from 71.6% in 2007 to 81.4% in 2011, while the percentage that used CoP, MoP, and MoM decreased significantly [Fig. 1]. One of the reasons for the dominant usage of hard-on-hard bearing surfaces may be that the principal diagnosis of primary THAs and the patient age group distribution in Korea differ from those in other countries. The most common indication for primary THA is osteonecrosis of the femoral head in Korea. In contrast, the majority of primary THAs are performed for osteoarthritis in Western countries. The choice of bearing surface may be affected by many factors, including the nation's medical delivery system, payment type, disease pattern, and age distribution of patients that undergo THA. In future, the results of a large-scale nationwide study on primary THAs using CoC bearing surfaces in Korea will be reported.
A cell-based tissue-engineered construct can be employed for treating meniscal lesions occurring in the non-vascularized inner two-thirds. The objective of this study was to test the hypothesis that both pre-differentiation of human bone marrow derived stromal cells (hBMSCs) into chondrogenic lineage before cell seeding and platelet-rich plasma (PRP) pretreatment on a PLGA mesh scaffold enhances the healing capacity of the meniscus with hBMSCs-seeded scaffolds PRP of 5 donors was mixed and used for the experiments. The woven PLGA mesh scaffold (VicrylTM, Ethicon) measuring 20×8 mm (thickness, 0.2 mm) was prepared. The scaffolds were immersed into 1,000 μl of PRP and were centrifuged at 150g for 10 min. Then, the scaffold was flipped 180° and the same procedure was done for the other side. After washing, the scaffolds were soaked into 1,000 μl of DMEM media. hBMSCs from an iliac crest of 10 patients after informed consent and approval of our IRB were induced into chondrogenic differentiation with chondrogenic media containing 10 ng/ml rhTGF-ß3 in 1.2% alginate bead culture system for 7 days. Then, 2×105 hBMSCs were recovered, seeded onto the scaffold, and cultured under dynamic condition. Based on the presence of pre-differentiation into chondrogenic lineage and the PRP pretreatment, 4 study groups were prepared. (no differentiation without PRP, no differentiation with PRP, chondrogenic differentiation without PRP, chondrogenic differentiation with PRP) Cell number for each cell-seeded scaffold was determined at 24 hours after seeding. Then, scaffolds were placed between human meniscal discs and were implanted subcutaneously in nude mice for 6 weeks (n=10 per group).Background
Methods
To compare and analyze the long term follow up clinical & radiological result after utilization of fixed-type & rotating-type implant for high flex both total knee replacement. This paper targeted 45 patients, 90 cases that got high flex both total knee replacement with utilization of fixed-type implant(LPS-flex®) & rotating-type implant(P.F.C® Sigma RP-F) for 1 patient by 1 operator(C.C.H) in our hospital from 2005.01 to 2006.11. Preoperative diagnoses were degenerative arthritis (43 patients, 86 cases), rheumatic arthritis (2 patients, 4 cases), mean age at the operation was 66.4 years old(54∼78), 3 men, 42 women, mean follow up period was 110.8months(97∼120). We compared and estimated Hospital for Special Surgery(HSS) score and Knee Society Score(KSS), Western Ontario and MacMaster Universities Osteoarthritis(WOMAC) score and mean range of motion of knee joint at pre-operation and last follow up for functional & clinical evaluation. And we compared and estimated change of femorotibial angle and radiolucency through erect AP & lateral x-ray at pre-, post-operation and last follow up using American Knee Society Roentgen Graphic Evaluation for radiological evaluation.Purpose
Subject & Method
The purpose of this study was to evaluate the impact of multi-radius (MR, n=20) versus gradually reducing radius (GR, n=18) knee design on the kinematics and kinetics of the knee during level ground walking one year after total knee arthroplasty. Thirty-eight knees with end-stage knee osteoarthritis were examined before and one year after total knee arthroplasty. The groups consisted of subjects who had undergone total knee arthroplasty with a representative MR designed implant (B Braun-Aesculap Vega® Knee System) and a representative GR designed implant (Depuy Attune® Knee System) (Figure 1). The kinematic and kinetic parameters of knee varus angle, first peak knee adduction moment, sagittal plane knee excursion and extensor moment were evaluated during gait, as well as the spatiotemporal gait outcomes of walking speed, stride length, cadence, step length, the percentage of stance phase. Comparisons of preoperative and postoperative outcomes were done by the paired t-test. Independent t-test was also done to compare the postoperative outcomes of MR designed implant and GR designed implant.Objectives
Materials and Methods
Few epidemiological studies from Asian countries have addressed this issue and reported that FAI is less prevalent in Asian population. The purpose of this study was to determine the prevalence of radiographic hip abnormalities associated with FAI in asymptomatic Korean volunteers. The authors hypothesized that the prevalence of FAI in Korean population would not be less than that in western population. Two hundred asymptomatic volunteers with no prior hip surgery or childhood hip problems underwent three-view plain radiography (pelvis anteroposterior (AP) view, Sugioka view, and 45° Dunn view) of both hips. Cam lesions were defined as the presence of the following signs on each views: pistol-grip deformity, osseous bump at the femoral head-neck junction, flattening of the femoral head-neck offset, or alpha angle >50°. Pincer lesions were determined by radiographic signs, including crossover sign, posterior wall deficient sign, or lateral center-edge (CE) angle >40°. Only positive cases agreed by both observers were defined as true FAI-related deformities. There were 146 male and 254 female hips, with a mean age of 34.7 years. On pelvis AP view, the prevalence of pistol grip deformity, bump, flattening, and alpha angle >50° was 1.3% (male 3.4%, female 0%), 0.8% (male 2.1%, female 0%), 0.8% (male 2.1%, female 0%), and 1.0% (male 2.7%, female 0%), respectively. On Sugioka view, the prevalence of bump, flattening, and alpha angle >50° was 9.8% (male 14.4%, female 7.1%), 13.5% (male 20.5%, female 9.4%), and 14.0% (male 26.7%, female 6.7%), respectively. On 45° Dunn view, the prevalence of bump, flattening, and alpha angle >50° was 8.0% (male 14.4%, female 4.3%), 17.5% (male 27.4%, female 11.8%), and 27.5% (male 44.5%, female 17.7%), respectively. The prevalence of cam lesion which was identified on at least one radiograph was 42.5% (male 62.3%, female 31.1%). The prevalence of cam lesion which was identified on ≥2 radiographs was 19.3% (male 30.8%, female 12.6%). The prevalence of cam type FAI (at least one cam lesion) was 2.0% (male 5.5%, female 0%) on pelvis AP view, 25.8% (male 37.0%, female 19.3%) on Sugioka view, and 35.8% (male 55.5%, female 24.4%) on 45° Dunn view. On pelvis AP view, the prevalence of crossover sign, posterior wall sign, and CE angle >40° was 20.0% (male 23.3%, female 18.1%), 20.8% (male 22.6%, female 19.7%), and 2.0% (male 2.7%, female 1.6%), respectively. The prevalence of pincer type of FAI (at least one pincer lesion) was 23.0% (male 27.4%, female 20.5%). In asymptomatic Korean volunteers, the prevalence of cam type FAI was low on AP pelvis radiographs, whereas the prevalence of cam type FAI on Sugioka and 45° Dunn view was found to be comparable to that previously reported in Western populations. The prevalence of pincer type FAI in asymptomatic Korean volunteers was also comparable that in Western populations and was similar in both gender. Considering the high prevalence of FAI morphologic features on plain radiographs in asymptomatic Korean populations, it is also important to determine whether FAI is a cause of hip pain when considering surgery in Asian patients.
To evaluate the causes and modes of complications after unicompartmental knee arthroplasty (UKA), and to identify its prevention and treatment method by analyzing the complications after UKA. A total of 1,576 UKAs were performed between January 2002 and December 2014 at a single-institution. Postoperative complications occurred in 89 knees (83 patients, 5.6%), and 86 of them were found in females and 3 in males. Their mean age was 61 years (range, 46 to 81 years) at the time of initial UKA and 66 years (range, 46 to 82 years) at the time of revision surgery. We analyzed the complications after UKA retrospectively andinvestigated the proper methods of treatment (Table 1).Background
Materials and Methods
Rotational alignment is important for the long-term success and good functional outcome of total knee arthroplasty (TKA). While the surgical transepicondylar axis (sTEA) is the generally accepted landmark on the distal femur, a precise and easily identifiable anatomical landmark on the tibia has yet to be established. Our aim was to compare five axes on the proximal tibia in normal and osteoarthritic (OA) knees to determine the best landmark for determining rotational alignment during TKA. One hundred twenty patients with OA knees and 30 without knee OA were recruited for the study. Computed tomography (CT) images were obtained and converted through multiplanar reconstruction so the angles between the sTEA and the axes of the proximal tibia could be measured. Five AP axes were chosen: the line connecting the center of the posterior cruciate ligament(PCL) and the medial border of the patellar tendon at the cutting level of the tibia (PCL-PT), the line from the PCL to the medial border of the tibial tuberosity (PCL-TT1), the line from the PCL to the border of the medial third of the tibia (PCL-TT2), the line from the PCL to the apex of the tibia (PCL-TT3), and the AP axis of the tibial prosthesis along with the anterior cortex of the proximal tibia (anterior tibial curved cortex, ATCC).Background
Methods
We aimed to investigate whether the anterior superior iliac spine could provide consistent rotational landmark of the tibial component during mobile-bearing medial unicompartmental knee arthroplasty (UKA) using computed tomography (CT). During sagittal tibial resection, we utilized the ASIS as a rotational landmark. In 47 knees that underwent postoperative CT scans after medial UKA, the tibial component position was assessed by drawing a line tangential to the lateral wall of the tibial component. Rotation of the tibial component was measured using two reference lines: a line perpendicular to the posterior cortical rim of the tibia (angle α) and Akagi's line (angle β). Instant bearing position and posterior cruciate ligament fossa involvement were also evaluated. External rotation of the tibial component relative to each reference line and external rotation of the bearing relative to the lateral wall of the tibial component were considered positive values.Purpose
Methods
Legg-Calve-Perthes disease (LCPD), a juvenile osteonecrosis of the femoral head (ONFH), can remain sequelae around hip joint, and results in osteoarthritis necessitating total hip arthroplasty (THA) in middle-age. THA for sequelae of LCPD needs specific concerns for anatomical deformity, leg length discrepancy (LLD), and relatively young patient's age. To date, few studies are available for the results of THA for LCPD sequelae. Moreover, there was no study for the result of Alumina-Alumina THA (Al-Al THA) in patient with LCPD sequelae, even excellent long term outcome of Al-Al THA has been documented in relatively young patients. The aim of this retrospective study is to evaluate the clinical and radiological outcome of Al-Al THA for LCPD sequelae, especially in terms of the restoration of LLD and the occurrence of complication. In addition, we compared the results of THA for LCPD sequelae with those for adult onset ONFH, in which THA is necessitated in relatively young age and excellent long term outcome has been proven after Al-Al THA. Between 1997 and 2007, 41 cementless Al-Al THA were performed in 37 patients with LCPD sequelae and followed up for mean, 10.4 years. Mean age at THA was 43.6 years. Using the propensity score matching with age, gender, and the length of follow-up as variables, 41 THAs in 37 patients were identified from 339 hips in 256 patients who underwent primary Al-Al THA for ONFH during the same period. Clinical and radiological outcomes in terms of implant survival, Harris hip score (HHS), LLD change, and perioperative complication were compared between the two groups.Introduction
Method
Buechel and Pappas invented a modified version of LCS RP system (Co-Cr) with light material (Titanium), axial rotation limiting bar and improved conformity. The purpose of this prospective randomized study was to compare the minimum 3-year clinical outcomes including lightness, preference, and instability between the Co-Cr implant system and the Titanium implant system in bilateral total knee arthroplasty. We prospectively enrolled 108 patients and 20 patients were lost to follow-up. Therefore, 88 patients (176 knees; mean age, 69.9±6.0years) were included in the study. The range of motion and clinical scores such as Knee Society score (KSS), Hospital for Special Surgery score (HSS) and Western Ontario and McMaster University (WOMAC) scores were measured preoperatively and postoperatively. At each follow-up, patients also complete a Likert scale questionnaire regarding subjective pain, lightness, left-right side preference (naturalness and satisfaction) and subjective instability. There were no significant differences in all preoperative variables between two groups (p>.05). Mean follow-up period was 46.3±8.8 (36 to 72) months. The mean weight of Titanium implants was three times lighter than that of Co-Cr implants (133.9g versus 390.1g, p<.01). At the minimum of 3-year follow-up, there were no significant differences in pain, range of motion (ROM), clinical scores including KSS, HSS, and WOMAC between both groups. Also, the study showed no significant differences with subjective pain, lightness, preference (convenience, naturalness, and satisfaction), and subjective instability between the Co-Cr protheses and the Titanium protheses (p>.05). No differences in clinical outcomes as well as subjective side-to-side differences between the Co-Cr prostheses and the Titanium prostheses were observed in the minimum 3-year follow-up. This implies that patients do not feel differently with two different weighted implants in mid-term follow-up.
This study was conducted to assess the clinical and radiologic results of total knee arthroplasty (TKA) with an allogenic bone graft using varus-valgus constrained (VVC) prostheses in knees with severe bone defects and unstable neuropathy. This study included 20 knees of 16 patients who underwent TKA between August 2001 and January 2006 due to unstable knees with severe bone destruction resulting from neuropathic arthritis. At the time of surgery, the mean age of the patients was 56 years. The mean length of the follow-up period was 10.7 years. A VVC condylar prosthesis was used with an allogenic femoral head graft to reconstruct large bony defects. Clinical results were evaluated using the Hospital for Special Surgery (HSS), Knee Society (KS) function, and Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scores. Three-dimensional computed tomography (3D-CT) was used to evaluate the radiological parameters, which included the tibiofemoral angle, loosening or osteolysis of components, and incorporation of the bone graft.Background
Methods
Most surgeons that have performed kinematically aligned TKA have noticed an overall better clinical outcome, better motion, better patient satisfaction, and a quicker recovery than their patients treated with mechanically aligned TKA. We prospectively followed all 128 knees who underwent primary total knee arthroplasty. The Lysholm knee Introduction
Materials and Methods
Positive expectations can increase compliance with treatment and realistic expectations may reduce postoperative dissatisfaction. Recently there are articles regarding expectations of patients from their TKA in western literature and only few articles based on Korean populations which don't encompass the whole spectrum of expectations in Korean patients. In all those articles based on pre-operative expectation, results were applied to whole expectation category uniformly not differentially. We aimed to document the pre-operative expectations in Korean patients undergoing total knee replacement using an established survey form and to determine whether expectations were influenced by socio-demographic factors and socio-demographic factors influences expectation items in particular category uniformly or differentially. Expectations regarding 19 items in the Knee Replacement Expectation Survey form were investigated in 228 patients scheduled for total knee replacement. The levels and distribution patterns of individual and summated expectation of five expectation categories; relief from pain, baseline activity, high flexion activity, social activity and psychological wellbeing, constructed from the 19 items were assessed. Univariate analyses and Binary logistic regression were performed and analyzed to examine the association of expectations with the socio-demographic factors.Introduction
Methods
Unicompartmental knee arthroplasty (UKA) is becoming an increasingly popular option in single compartment osteoarthritis. As a result, diverse re-operations including revisions to total knee arthroplasty (TKA) has also increase. The objective of this study is to investigate the distribution of causes of re-operations after UKA and to analyze the types of re-operations. We retrospectively reviewed 691 UKAs performed on 595 patients between January 2003 and December 2011. Except in one case, all UKAs were performed for medial compartment osteoarthritis of the knee. The UKAs were performed in 487 (81.8%) women and 108 (18.2%) men. The mean age at the time of UKA was 61.5 years (47 to 88 years). Mobile-bearing designs were implanted in 627 (90.7%) knees (626- Oxford knee and 1- Scorpio knee) and fixed designs were implanted in 64 (9.3%) knees (42- Tornier and 18- Zimmer). The mean interval between UKA and second operation was 15.4 months (10 days to 10 years) and between second and third operation was 7.7 months (5 weeks to 17 months). In the re-operation group, there were 50 knees (48 patients) with 38 female and 10 male patients.Introduction
Method
The purpose of this study was to demonstrate postoperative improvement and high satisfaction rates after a surgical approach that includes arthroscopic labral repair only, in patients with borderline dysplasia, without instability. Between September 2009 and December 2011, patients less than 50 years old who underwent hip arthroscopy for symptomatic intra-articular hip disorders, with a lateral center-edge (CE) angle between 20 and 25, were included in this study. Patients with Tönnis grade 2 or greater, hip joint space narrowing, severe hip dysplasia, hip joint instability and Legg-Calve-Perthes disease were excluded. Patient-reported outcome scores, including the modified Harris Hip Score (mHHS), Western Ontario and McMaster Universities Arthritis index (WOMAC), and visual analog scale (VAS) for pain were obtained in all patients preoperatively and at 1, 2, and 3 years postoperatively.Purpose
Methods
To evaluate the clinical and radiographic outcomes of total knee arthroplasty using Vega® Knee System (B Braun-Aesculap, Tuttlingen, Germany) [Fig. 1] designed to allow high flexion by shortening the length of posterior condylar flange of femoral component after at least 2 year and to assess the occurrence of periprosthetic osteolysis and loosening at final follow-up. Of the patients who underwent total knee arthroplasty using Vega® Knee System between April 2011 and May 2013, 40 patients (46 knees) were enrolled. The mean age of the patients at the time of surgery was 72.3 years and the mean follow-up period was 29.4 months. Clinical parameters, including Knee Society Knee score, Knee Society Function score, maximal flexion and range of motion were evaluated. Relationship between postoperative maximal flexion and radiographic factors including the posterior tibial slope, the femoral condylar offset and the change of the posterior flange length of femoral condyle was analyzed. Also, the occurrence of periprosthetic osteolysis and loosening was assessed.Objectives
Materials and Methods
In this study, we investigated the long-term clinical results and survivorship of minimally invasive unicompartmental knee arthroplasty (UKA) by collecting cases that have been implanted for >10 years ago. Medial UKA on 180 cases in 142 patients was performed over a period of 1 year after the first introduction of minimally invasive UKA from January 2002 to December 2002. Among these, 166 cases in 128 patients who underwent Oxford phase 3 medial UKA using the minimally invasive surgery, with the exclusion of 14 cases including 10 cases of follow-up loss and 4 cases of death, were selected as the subject. The mean age of the patients at the time of surgery was 61 years, and the duration of the follow-up was minimum 10 years. All the preoperative diagnosis was osteoarthritis of the knee joint. Clinical and radiographic assessments were measured by the Knee Society clinical rating system, and the survival analysis was confirmed by the Kaplan–Meier method with 95% confidence interval (CI).Background
Methods
To identify the modes of failure after total knee arthroplasty (TKA) in patients ≤ 55 years of age and to compare with those ≥ 56 years of age in patients who underwent revision TKA. We retrospectively reviewed 256 revision TKAs among patients who underwent TKA for knee osteoarthritis between January 1992 and December 2012. The causes of TKA failure were analyzed and compared between those ≤ 55 years of age and those ≥ 56 years of age. The age at the time of primary surgery was ≤ 55 years in 30 patients (31 knees) and ≥ 56 years in 210 patients (225 knees).Purpose
Materials and Methods
Among many factors that influence the outcomes of Total Knee Arthroplasties (TKAs), the mechanical alignment has played major roles for the success of TKA, the survival rates of the implants, and patient functionality. Most, but not all, studies have shown that alignment of the mechanical axis in the coronal plane within a range of 3° varus/valgus is associated with improved long-term function and increased survival rates. Robot-assisted TKA has been developed to improve improves the accuracy and precision of component implantation and mechanical axis (MA) alignment. We hypothesised that robot-assisted TKA would lead to a more accurate leg alignment and component implantation, and thus, improve radiological and clinical outcomes. Between January 2003 and December 2004, a total of 98 primary TKA procedures were compared: 49 using a robotic-assisted procedure and 49 using conventional manual techniques. The cohorts were followed for 121.2 and 119.5 months on average, respectively. Radiographic assessments of the patients were performed preoperatively and at final follow-up and made according to the Knee Society Roentgenographic Evaluation System (KSRES) which included measurements of the coronal mechanical axis and sagittal and coronal inclinations of femoral and tibial components. The radiographic measurements were made using a PACS (Picture Archiving and Communication System). Clinical assessments were performed preoperatively, and at a final follow-up date that was a minimum of postoperative nine years. The clinical results included ranges of motion (ROM), Hospital for Special Surgery (HSS) scores, Western Ontario and McMaster University (WOMAC) scores (for pain and function). The radiographic results showed no statistical differences when comparing the means of the two groups. When considering outliers (defined as error ≥ ±3°) for the mechanical axis, femoral coronal and sagittal inclinations, and tibial coronal and sagittal inclinations, the ROBODOC group had zero outliers for all measurements except for one in tibial sagittal inclination. On the other hand, the conventional group had 12 outliers for mechanical axis, 2 for femoral coronal inclination, 3 for femoral sagittal inclination, 3 for tibial coronal inclination, and 4 for tibial sagittal inclination. However, there were no statistically significant differences between groups for ROM, HSS, or WOMAC scores at the final follow-up. The results of this study support previous work and demonstrate that the ROBODOC-assisted implantation of TKA results in better radiographic outcomes and better ligament balance with equivalent safety when compared to conventional TKA at a minimum follow-up of nine years.
Although the use of stems in revision total knee arthroplasty (RTKA) enhances survival by improving the stability of implant, questions as to the optimal fixation method as well as the vertical extent of the cement, remain unanswered. This study aimed 1) to determine the correlation between the vertical extent of cement and implant loosening; and 2) to determine the minimum cementing extent for a stable implant in revision TKA with a hybrid technique. We retrospectively analyzed 109 stemmed RTKAs with average follow-up of 63 months. In each case, a single varus-valgus constrained implant was used and fixed with a hybrid technique. During surgery, stem was partially covered with cement beyond stem-implant junction. Stability of implant was evaluated according to the modified Knee Society Radiographic Scoring System. Cementing extent was defined as length from implant base to the end of the radiopaque line around the stem. The correlation between the vertical cementing extent and implant stability was analyzed, and the minimal vertical cementing extent for a stable implant was evaluated with a scatter plot.Purpose
Materials and Methods
Over the past twenty years, the Low Contact Stress Rotating Platform (LCS RP) showed good results. Buechel and Pappas invented the Buechel-Pappas Knee (B-P Knee) system that is a modified version of the LCS system with different material (titanium), axial rotation limiting bar and improved conformity. The purpose of this prospective randomized study was to compare the 2-year clinical outcomes between two implants in the same patients who had been operated with bilateral TKAs. We prospectively enrolled 107 patients and 18 patients were lost to follow-up. Therefore, 89 patients (178 knees; mean age, 69.8±6.0years) were included in the study. The range of motion and clinical scores such as Knee Society score (KSS), Hospital for Special Surgery score (HSS) and Western Ontario and McMaster University (WOMAC) scores were measured preoperatively and postoperatively. At each follow-up, patients also complete a Likert scale questionnaire regarding subjective pain, lightness, left-right side preference (naturalness and satisfaction) and subjective instability. There were no significant differences in all preoperative variables between the two groups(
This study aimed to determine the optimal formulation of antibiotic-loaded bone cement (ALBC) for periprosthetic joint infection (PJI) using both in vitro and in vivo models incorporating various combinations of gram-positive and gram-negative antibiotics. The in vitro antibiotic release characteristics and antibacterial capacities of ALBCs loaded with either 4 g of vancomycin or teicoplanin and 4 g of ceftazidime, imipenem, or aztreonam were measured against methicillin-susceptible S. aureus, methicillin-resistant S. aureus, coagulase-negative staphylococci, Pseudomonas aeruginosa and Escherichia coli. ALBC spacers with superior in vitro antibacterial capacity were then implanted into ten patients (five females and five males between 29 and 75 years of age) diagnosed with chronic hip/knee PJIs and antibacterial activities within joint fluid were measured. The average duration of ALBC spacer implantation was 80 days (range, 36–155 days). Antibiotic concentrations and antibacterial activities of joint fluid at the site of infection were measured during the initial period as well as several months following spacer implantation. Cement samples loaded with vancomycin/ceftazidime or teicoplanin/ceftazidime exhibited equal or longer antibacterial duration against test bacteria as compared with other ALBCs. Joint fluid samples exhibited antibacterial activity against the test microorganisms including ATCC strains and clinically isolated strains. There were no adverse systemic effects, infection at second stage re-implantation, or recurrent infection at final follow-up. Vancomycin/ceftazidime ALBC provided broad antibacterial capacity both in vitro and in vivo and was shown to be an effective and safe therapeutic measure in the treatment of hip/knee PJIs. We thank H.Y. Hsu for performing bioassay.
The objective of this study was to compare the elution characteristics, antimicrobial activity and mechanical properties of antibiotic-loaded bone cement (ALBC) loaded with powdered antibiotic, powdered antibiotic with inert filler (xylitol), or liquid antibiotic, particularly focusing on vancomycin and amphotericin B. Cement specimens loaded with 2 g of vancomycin or amphotericin B powder (powder group), 2 g of antibiotic powder and 2 g of xylitol (xylitol group) or 12 ml of antibiotic solution containing 2 g of antibiotic (liquid group) were tested. Vancomycin elution was enhanced by 234% in the liquid group and by 12% in the xylitol group compared with the powder group. Amphotericin B elution was enhanced by 265% in the liquid group and by 65% in the xylitol group compared with the powder group. Based on the disk-diffusion assay, the eluate samples of vancomycin-loaded ALBC of the liquid group exhibited a significantly larger inhibitory zone than samples of the powder or the xylitol group. Regarding the ALBCs loaded with amphotericin B, only the eluate samples of the liquid group exhibited a clear inhibitory zone, which was not observed in either the xylitol or the powder groups. The ultimate compressive strength was significantly reduced in specimens containing liquid antibiotics. Adding vancomycin or amphotericin B antibiotic powder in distilled water before mixing with bone cement can significantly improve the efficiency of antibiotic release than can loading ALBC with the same dose of antibiotic powder. This simple and effective method for preparation of ALBCs can significantly improve the efficiency of antibiotic release in ALBCs. We thank H.Y. Hsu for performing the bioassay.
The aim was to compare the efficacy of selective ultrasound-screening (SUSS) for developmental dysplasia of the hip (DDH) to clinical screening alone, by comparing outcomes in a contemporary group with those from a 40 year old cohort. This was a retrospective cohort study. The department's DDH and surgical databases were used to identify all cases of DDH, and all cases of surgery for DDH during the study period (2009–13). Patients born outside our region, and teratologic cases were excluded from analysis. The Obstetric database provided the total number of live births over the five-year period. This data was used to calculate the incidence of late-diagnosis (age over 3 months) DDH and the rate of surgery for DDH in our region. These results were compared to those of a similar study from our institution published in 1977, after the introduction of universal clinical screening. Relative risk (RR) was calculated for the two groups, and analysed for statistical significance. The incidence of late-diagnosis DDH over the recent 5-year study period was 0.66/1000 live births, compared to 0.6/1000 in the control group. The RR for late-diagnosis DDH was not significantly different between the two groups (RR 1.14, 95% CI 0.6 to 2.2). The rate of surgery for DDH was 0.86/1000, compared to 0.9/1000 live births in the control group. The RR for surgery for DDH in the current study population compared to the historic control was 0.97, but this difference was not statistically significant (95% C.I. 0.57 to 1.68; p=0.92). Despite advances in screening for DDH over the last 40 years, neither the incidence of late diagnosis DDH, nor rates of surgery for DDH in our region have changed. Whilst previous studies have demonstrated that SUSS does not eliminate late-presenting DDH, this study suggests it confers no advantage over clinical screening alone.
Low-intensity pulsed ultrasound (LIPUS) enhanced osteogenic differentiation of osteoprogenitor cells derived from mouse induced pluripotent cells (iPSCs) without embryoid body formation. Our findings provide insights on the development of LIPUS as an effective technology for bone regeneration strategies using iPSCs. iPSCs represent a promising cell source for regenerative medicine such as bone regeneration because of their unlimited self-renewal property and ability of differentiation into all somatic cell types. Recently, we developed an efficient protocol for generating a highly homogeneous population of osteoprogenitor cells from embryonic stem cells by using a direct-plating method without EB formation step. It is well-recognised that LIPUS accelerates the fracture healing. There have been several reports showing that LIPUS stimulates the osteogenic differentiation of mesenchymal stem cells (MSCs) Summary Statement
Introduction
The purpose of this study was to compare the
results of proximal and distal chevron osteotomy in patients with moderate
hallux valgus. We retrospectively reviewed 34 proximal chevron osteotomies without
lateral release (PCO group) and 33 distal chevron osteotomies (DCO
group) performed sequentially by a single surgeon. There were no
differences between the groups with regard to age, length of follow-up,
demographic or radiological parameters. The clinical results were
assessed using the American Orthopaedic Foot and Ankle Society (AOFAS)
scoring system and the radiological results were compared between
the groups. At a mean follow-up of 14.6 months (14 to 32) there were no significant
differences in the mean AOFAS scores between the DCO and PCO groups
(93.9 (82 to 100) and 91.8 (77 to 100), respectively; p = 0.176).
The mean hallux valgus angle, intermetatarsal angle and sesamoid
position were the same in both groups. The metatarsal declination
angle decreased significantly in the PCO group (p = 0.005) and the
mean shortening of the first metatarsal was significantly greater
in the DCO group (p <
0.001). We conclude that the clinical and radiological outcome after
a DCO is comparable with that after a PCO; longer follow-up would
be needed to assess the risk of avascular necrosis. Cite this article:
Low-intensity pulsed ultrasound (LIPUS) has been reported to enhance healing of fracture and nonunion. Bone morphogenetic protein-7 (BMP-7) has also been reported to promote bone formation. Recently, we demonstrated progenitor cells with osteogenic/chondrogenic differentiation potential existed in human fracture hematoma and nonunion tissue. We hypothesised the combined application of LIPUS and BMP-7 would cause major effect on osteogenesis of hematoma-derived cells (HCs) and nonunion tissue-derived cells (NCs).Introduction
Hypothesis
Our previous study using microarray analysis showed that Rad (Ras associated with diabetes) was highly expressed in nonunion. The purpose of this study is to investigate the gene expression and immunolocalization of Rad, and other Ras-related G proteins: Rem1 and Rem2 in fracture/nonunion site using rat experimental models. We hypothesized that Rad had a significant role in nonunion formation.Introduction
Hypothesis
iPSCs represent a promising cell source for bone regeneration. To generate osteoprogenitor cells, most protocols use the generation of embryoid bodies (EBs). However, these protocols give rise to heterogeneous population of different cell lineage. We hypothesized that a direct plating method without EB formation step could be an efficient protocol for generating a homogeneous population of osteoprogenitor cells from iPSCs.Introduction
Hypothesis
Parathyroid hormone 1–34 (PTH) has been reported to accelerate fracture healing. Previously, we demonstrated human fracture hematoma contained osteo-/chondro-progenitor cells. To date, there has been no study investigating the effect of PTH on fracture hematoma-derived cells (HCs) in vitro. We hypothesized PTH treatment affected osteogenesis and chondrogenesis of HCs.Introduction
Hypothesis
Soft-tissue balancing is crucial in total knee arthroplasty, but proper release of medial collateral ligament is a challenging procedure. It has been well recognized that medial gap tends to be more tight than lateral gap in varus knees after surgery. The purpose of this study is to investigate the incidence and predictable factors of medial tibial bone remodeling following navigation-assisted total knee arthroplasty. One hundred and sixty-six consecutive patients (221 knees) who underwent navigation-assisted total knee arthroplasty and followed during a minimum of 1 year were included in this study. Radiographic examination including anteroposterior and lateral view of both knees were performed at a regular follow-up schedules of 6 weeks, 3 months, 6 months, 1 year and thereafter, annually after surgery. An independent investigator identified the presence of medial tibial bone remodeling at each follow-up. All information on potential factors affecting medial tibial remodeling were retrieved and classified into 2 types (patient- and surgery-related).Background and Purpose
Materials and methods
Revision TKA using CCK prosthesis showed comparable outcome to PS prosthesis in clinical and radiological results. In revision total knee arthroplasty (TKA), the goal should be to obtain good motion, function and most importantly stability. The stability depends on remaining soft tissue and implant design. The more the ligaments retain function, the less the implant constraint is needed to achieve stability. With increased constraint, the transfer of joint reaction forces to implant-bone interface may lead to mechanical loosening of the implant. Constrained condylar knee (CCK) prosthesis provides more constraint compared with posterior stabilized (PS) prosthesis. The purpose of this study was to compare the clinical, radiological outcome and survivorship of CCK and PS prosthesis in revision TKA.Summary
Introduction
Many literatures regarding more specific tests to diagnose the supraspinatus tendon injuries and the best rehabilitation methods to strengthen the supraspinatus have been published. However, conflicting results have been reported. 2-deoxy-2-[18F] fluoro-D-glucose (FDG) positron emission tomography (PET) has been recently used to assess skeletal muscle activities in various fields. To evaluate & compare the metabolic activities of deltoid & rotator cuff muscles after the full-can & empty-can exercises using PET-CT.Introduction
Purpose
UC TKA showed similar anteroposterior translation and more femoral external rotation of earlier onset when compared to PS TKA. Recently highly conforming ultracongruent TKA has been reintroduced with improved wear characteristics and lower complications. The purpose of the study was to assess kinematics and clinical outcome of posterior stabilized and ultracongruent rotating-platform mobile bearing TKA.Summary
Introduction
Early failure of metal-on-metal (MoM) total hip replacements (THR) is now well established. We review 93 consecutive patients with CPT¯ stems MoM THR. Our series demonstrates a new mechanism of failure, which may be implant combination specific. Between January 2005 and June 2009, 93 consecutive MoM total hip replacements were preformed using CPT stems by 3 surgeons at our unit. 73 CPT¯ stems, Metasul¯ Large Diameter Heads (LDH) with Durom¯ acetabulae and 20 CPT¯ stems, Metasul¯ 28mm diameter heads in Allofit¯ shells (zimmer). Clinical outcomes were collected prospectively before surgery, at 3 months, 1 year, 2 years, 3 years, and at 5 years post surgery. Revision for any cause was taken as the primary endpoint and the roentgenograms and explanted prostheses were analyzed for failure patterns. In the LDH/Durom¯ group a total of 13 (18%) patients required revision (figs. 1) at a median of 35 months (range 6-44). 6 (8%) for periprosthetic fracture. All 6 periprostethic fractures were associated with minimal or no trauma and all had ALVAL identified histologically. To date there have been no failures in the CPT¯/28mm head Allofit¯ group. Several failures demonstrated bone loss in Gruen zones 8 ± 9 ± 10 (fig. 2). We demonstrate an unacceptably high rate of failure in CPT¯ MoM LDH hip replacements, with a high failure secondary to periprosthetic fracture and postulate a mechanism associated with local toxicity to metal ions. We strongly advise against this combination of prosthesis.
We retrospectively reviewed 30 two-stage revision
procedures in 28 patients performed for fungal peri-prosthetic joint
infection (PJI) after a primary total knee replacement. Patients were
followed for at least two years or until the infection recurred.
The mean follow-up for patients who remained free of infection was
4.3 years (2.3 to 6.1). Overall, 17 patients were assessed as American
Society of Anesthesiologists grade 3 or 4. The surgical protocol included
removal of the infected implant, vigorous debridement and insertion
of an articulating cement spacer. This was followed by at least
six weeks of antimicrobial treatment and delayed reimplantation
in all patients. The mean interval between removal of the prosthesis
and reimplantation was 9.5 weeks (6 to 24). After reimplantation,
patients took antifungal agents orally for a maximum of six months. Fungal PJIs can be treated successfully by removal of all infected
material, appropriate antimicrobial treatment and delayed reimplantation.
The rates of MRSA infection for 2005, 2006 and 2007 were 0.49%, 0.28% and 0.24% respectively (binomial comparison, 2005 to 2006, p<
0.005 and 2005 to 2007, p<
0.005). Again when trauma and elective units were seperated there was a corrected rate of infection of 0.14% and 0.33% respectively. In 2005 there was 9 Superficial Incisional (SI), 8 Organ Space Infection(OSI) and 4 Deep Incisional (DI), 2006 had 7 SI, 4 OS and 4 DI and in 2007 there was 9 SI, 9 OS and 1 DI seen in the elective unit There was no Deep MRSA infection seen in the new ring fenced trauma unit. MRSA infection was found to cause a considerable increase in length of stay with normal orthopaedic patients staying a mean of 5 days whilst MRSA patients staying 23.4 days (p=0.000).
The use of allografts for the treatment of bone tumours in children is limited by nonunion and the difficulty of finding a suitable graft. Furthermore, appositional growth can’t be expected of an allograft. We used an overlapping allograft in 11 children, with a mean age of ten years (4 to 15), with a mean follow-up of 24.1 months (20 to 33). There were five intercalary and six intra-articular resections, and the tumours were in the femur in six cases and the humerus in five. Rates of union, times to union, remodelling patterns and allograft-associated complications were evaluated. No allograft was removed due to a complication. Of the 16 junctional sites, 15 (94%) showed union at a mean of 3.1 months (2 to 5). Remodelling between host and allograft was seen at 14 junctions at a mean of five months (4 to 7). The mean Musculoskeletal Tumor Society score was 26.5 of 30 (88.3%). One case of nonunion and another with screw protrusion required re-operation. Overlapping allografts have the potential to shorten time to union, decrease rates of nonunion and have positive appositional growth effect.
