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The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 10 | Pages 1356 - 1362
1 Oct 2010
Simpson DJ Kendrick BJL Hughes M Glyn-Jones S Gill HS Rushforth GF Murray DW

We have evaluated the difference in the migration patterns over two years of two cementless stems in a randomised, controlled trial using radiostereophotogrammetric analysis (RSA). The implants studied were the Furlong HAC stem, which has good long-term results and the Furlong Active stem, which is a modified version of the former designed to minimise stress concentrations between the implant and bone, and thus to improve fixation.

A total of 23 Furlong HAC and 20 Furlong Active stems were implanted in 43 patients. RSA examinations were carried out immediately post-operatively and at six, 12 and 24 months post-operatively.

The subsidence during the first year in the Furlong HAC stem, was approximately one-third that of the Furlong Active stem, the measured mean subsidence of the femoral head at six months being 0.27 mm (95% confidence interval (CI) 0.03 to 0.51) and 0.99 mm (95% CI 0.38 to 1.60), respectively (p = 0.03). One Active stem continued to subside during the second year. All hips, regardless of the type of stem were clinically successful as judged by the Oxford hip score and a derived pain score without any distinction between the two types of stem.

The initial stability of the Furlong Active stem was not as good as the established stem which might compromise osseo-integration to the detriment of long-term success. The changes in the geometry of the stem, to minimise stress have affected the attainment of initial stability.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 8 | Pages 1072 - 1078
1 Aug 2010
Grammatopoulos G Pandit H Glyn-Jones S McLardy-Smith P Gundle R Whitwell D Gill HS Murray DW

Pseudotumours are a rare complication of hip resurfacing. They are thought to be a response to metal debris which may be caused by edge loading due to poor orientation of the acetabular component. Our aim was to determine the optimal acetabular orientation to minimise the risk of pseudotumour formation.

We matched 31 hip resurfacings revised for pseudotumour formation with 58 controls who had a satisfactory outcome from this procedure. The radiographic inclination and anteversion angles of the acetabular component were measured on anteroposterior radiographs of the pelvis using Einzel-Bild-Roentgen-Analyse software. The mean inclination angle (47°, 10° to 81°) and anteversion angle (14°, 4° to 34°) of the pseudotumour cases were the same (p = 0.8, p = 0.2) as the controls, 46° (29° to 60°) and 16° (4° to 30°) respectively, but the variation was greater. Assuming an accuracy of implantation of ± 10° about a target position, the optimal radiographic position was found to be approximately 45° of inclination and 20° of anteversion. The incidence of pseudotumours inside the zone was four times lower (p = 0.007) than outside the zone.

In order to minimise the risk of pseudotumour formation we recommend that surgeons implant the acetabular component at an inclination of 45° (± 10) and anteversion of 20° (± 10) on post-operative radiographs. Because of differences between the radiographic and the operative angles, this may be best achieved by aiming for an inclination of 40° and an anteversion of 25°.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 390 - 390
1 Jul 2010
Kwon Y Ostlere S Mclardy-Smith P Gundle R Whitwell D Gibbons C Taylor A Pandit H Glyn-Jones S Athanasou N Beard D Gill H Murray D
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Introduction: Despite the satisfactory short-term implant survivorship of MoM hip resurfacing arthroplasty, symptomatic abnormal periprosthetic soft-tissue masses relating to the hip joint, ‘pseudotumours’, are being increasingly reported. These were found be locally destructive, requiring revision surgery in 75% of patients. Asymptomatic pseudotumours have not been previously investigated.

Methods: The aims were: (1) to investigate the prevalence of asymptomatic pseudotumours; and (2) to investigate their potential association with the level of metal ions. A total of 160 hips in 123 patients with a mean age 56 years (range 33–73) were evaluated at a mean follow-up of 61 months (range 13–88). Radiographs and OHS were assessed. Patients with a cystic or solid mass detected on the ultrasound/MRI had an aspiration or biopsy performed. Cobalt and chromium levels were analysed using Inductively-Coupled Plasma Spectrometer.

Results: Pseudotumours were found in 6 patients (5F: 1M). In 80% of bilateral cases, it was found in both sides. Histological examination showed extensive necrosis and diffuse lymphocyte infiltration. The presence of pseudotumour was associated with higher serum cobalt (9.2 μg/L vs. 1.9μg/L, p< 0.001) and chromium levels (12.0μg/L vs. 2.1μg/L, p< 0.001); higher hip aspirate cobalt (1182 μg/L vs. 86.2μg/L, p=0.003) and chromium levels (883μg/L vs. 114.8μg/L, p=0.006); and with inferior OHS (23 vs. 14 p=0.08).

Discussion: The prevalence of asymptomatic pseudotumour (5%) was higher than previously reported for the symptomatic pseudotumours (1%). There was a sixfold elevation of serum and a twelve-fold elevation of hip aspirate levels of cobalt and chromium in patients with pseudotumours. This suggests that pseudotumours may be a biological consequence of the large amount of metal debris generated in vivo. The association between pseudotumour and elevated metal ion levels might theoretically be explained by either systemic hypersensitivity responses to metal ions or local cytotoxic effects due to a high level of metal ions.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 3 | Pages 356 - 361
1 Mar 2010
Kwon Y- Glyn-Jones S Simpson DJ Kamali A McLardy-Smith P Gill HS Murray DW

The presence of pseudotumours, which are soft-tissue masses relating to the hip, after metal-on-metal hip resurfacing arthroplasty has been associated with elevated levels of metal ions in serum, suggesting that pseudotumours occur when there is increased wear. We aimed to quantify the wear in vivo of implants revised for pseudotumours (eight) and of a control group of implants (22) revised for other reasons of failure.

We found that the implant group with pseudotumours had a significantly higher rate of median linear wear of the femoral component at 8.1 μm/year (2.75 to 25.4) than the 1.79 μm/year (0.82 to 4.15; p = 0.002) of the non-pseudotumour group. For the acetabular component a significantly higher rate of median linear wear of 7.36 μm/year (1.61 to 24.9) was observed in the pseudotumour group compared with 1.28 μm/year (0.81 to 3.33, p = 0.001) in the other group. Wear of the acetabular component in the pseudotumour group always involved the edge of the implant, indicating that edge-loading had occurred.

Our findings are the first direct evidence that pseudotumour is associated with increased wear at the metal-on-metal articulation. Furthermore, edge-loading with the loss of fluid-film lubrication may be an important mechanism of generation of wear in patients with a pseudotumour.


The Journal of Bone & Joint Surgery British Volume
Vol. 91-B, Issue 12 | Pages 1566 - 1574
1 Dec 2009
Glyn-Jones S Pandit H Kwon Y Doll H Gill HS Murray DW

Metal-on-metal hip resurfacing is commonly performed for osteoarthritis in young active patients. We have observed cystic or solid masses, which we have called inflammatory pseudotumours, arising around these devices. They may cause soft-tissue destruction with severe symptoms and a poor outcome after revision surgery. The aim of this study was to determine the incidence of and risk factors for pseudotumours that are serious enough to require revision surgery.

Since 1999, 1419 metal-on-metal hip resurfacings have been implanted by our group in 1224 patients; 1.8% of the patients had a revision for pseudotumour. In this series the Kaplan-Meier cumulative revision rate for pseudotumour increased progressively with time. At eight years, in all patients, it was 4% (95% confidence interval (CI) 2.2 to 5.8). Factors significantly associated with an increase in revision rate were female gender (p < 0.001), age under 40 (p = 0.003), small components (p = 0.003), and dysplasia (p = 0.019), whereas implant type was not (p = 0.156). These factors were inter-related, however, and on fitting a Cox proportional hazard model only gender (p = 0.002) and age (p = 0.024) had a significant independent influence on revision rate; size nearly reached significance (p = 0.08). Subdividing the cohort according to significant factors, we found that the revision rate for pseudotumours in men was 0.5% (95% CI 0 to 1.1) at eight years wheras in women over 40 years old it was 6% (95% CI 2.3 to 10.1) at eight years and in women under 40 years it was 13.1% at six years (95% CI 0 to 27) (p < 0.001).

We recommend that resurfacings are undertaken with caution in women, particularly those under 40 years of age but they remain a good option in young men. Further work is required to understand the aetiology of pseudotumours so that this complication can be avoided.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 406 - 406
1 Sep 2009
Pandit H Glyn-Jones S Gundle R Whitwell D Gibbons C Ostlere S Athanasou N Gill H McLardy-Smith P Murray D
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Introduction: We report on a group of 20 metal-on-metal resurfaced hips (17 patients) presenting with a soft tissue mass associated with various symptoms; these masses we termed pseudotumours. All patients underwent plane radiography; CT, MRI and ultrasound investigations were also performed for some patients. Where samples were available histology was performed.

Methods: All patients in this series were female. Presentation was variable; the most common symptom was pain or discomfort in the hip region. Other symptoms included spontaneous dislocation, nerve palsy, a noticeable mass or a rash. The common histological features were extensive necrosis and lymphocytic infiltration. Fourteen of the 20 cases (70%) have so far required revision to a conventional hip replacement and their symptoms have either settled completely or improved substantially since the revision surgery. Two of the three bilateral cases have asymptomatic pseudotumours on the opposite side.

Conclusions: We estimate that about 1% of patients develop a pseudotumour in the first five postoperative years after a hip resurfacing. The cause of these pseudotumours is unknown and is probably multi-factorial, further work is required to define this; they may be manifestations of a metal sensitivity response. We are concerned that with time the incidence of these pseudotumours will increase.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 25 - 25
1 Mar 2009
Glyn-Jones S Beard D Murray D Gill H
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Introduction: Interest in hip resurfacing has recently been renewed by the introduction of metal-on-metal designs; it is being increasingly used for young patients, with over 30,000 implanted worldwide. The 5 year clinical results appear promising, but there are no long term data available. Radiostereometry (RSA) measures of implant migration have been able to predict implant failure; specifically large and continuous migration predicts aseptic loosening. We present the results of a five year RSA study examining the migration of the Birmingham Hip Resurfacing (BHR).

Methods: Twenty-four subjects with primary OA were implanted with the BHR device and with bone markers for RSA. RSA measurements were taken at 3, 6, 12, 24 and 60 months. The migration of the head and the tip of femoral component were measured in 3D.

Results: Preliminary analysis showed that the total 3D migration of the head and tip over five years was 0.32mm and 0.23mm respectively.

Discussion: A distal migration of more than 0.4mm over 2 years increases the likelihood of failure in conventional stems. The total migration of the BHR was approximately 0.3mm over a five year period, significantly less than cemented THR devices. The device is stable and this is promising for long-term survival.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 7 | Pages 847 - 851
1 Jul 2008
Pandit H Glyn-Jones S McLardy-Smith P Gundle R Whitwell D Gibbons CLM Ostlere S Athanasou N Gill HS Murray DW

We report 17 patients (20 hips) in whom metal-on-metal resurfacing had been performed and who presented with various symptoms and a soft-tissue mass which we termed a pseudotumour. Each patient underwent plain radiography and in some, CT, MRI and ultrasonography were also performed. In addition, histological examination of available samples was undertaken.

All the patients were women and their presentation was variable. The most common symptom was discomfort in the region of the hip. Other symptoms included spontaneous dislocation, nerve palsy, a noticeable mass or a rash. The common histological features were extensive necrosis and lymphocytic infiltration. To date, 13 of the 20 hips have required revision to a conventional hip replacement. Two are awaiting revision.

We estimate that approximately 1% of patients who have a metal-on-metal resurfacing develop a pseudotumour within five years. The cause is unknown and is probably multifactorial. There may be a toxic reaction to an excess of particulate metal wear debris or a hypersensitivity reaction to a normal amount of metal debris. We are concerned that with time the incidence of these pseudotumours may increase. Further investigation is required to define their cause.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 398 - 398
1 Jul 2008
Glyn-Jones S Pandit H Whitwell D Athanasou N Gibbons M
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Purpose of study: We report the results of a prospective case series of 10 patients who developed tumour-like masses following resurfacing arthroplasty

Method: Ten subjects were referred to the tumour service at the Nuffield Orthopaedic Centre with symptomatic masses around the hip, all had previously received a resurfacing arthroplasty.

We report the clinical, radiographic and histologic features of these cases.

Results: MRI and ultrasound scanning was preformed, which demonstrated masses with solid and cystic components.

Biopsy was performed and subsequent histological examination revealed a profound plasma-cell lymphocytic response associated with metal wear debris.

There were no infections in this series.

Three subjects required revision surgery.

Conclusion: Over 50,000 resurfacing arthroplasties have been implanted worldwide over the past ten years. Although the early clinical results are encouraging little is known about the long term consequences of large head metal on metal bearing surfaces. Despite this, these devices are being widely marketed and are often implanted in younger patients. Resurfacing arthroplasties are associated with high serum and urine metal ion concentrations, metal particles have also been shown to migrate along the lymphatic system. In addition, there is now evidence that high local metal ion concentrations can induce haempoietic cancers.

This study suggests that resurfacing arthoplasty can also induce a local hypersensitivity reaction in response to metal wear debris. It therefore raises new concerns regarding the long-term safety of this procedure.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 5 | Pages 556 - 561
1 May 2008
Glyn-Jones S McLardy-Smith P Gill HS Murray DW

The creep and wear behaviour of highly cross-linked polyethylene and standard polyethylene liners were examined in a prospective, double-blind randomised, controlled trial using radiostereometric analysis.

We randomised 54 patients to receive hip replacements with either highly cross-linked polyethylene or standard liners and determined the three-dimensional penetration of the liners over three years.

After three years the mean total penetration was 0.35 mm (SD 0.14) for the highly cross-linked polyethylene group and 0.45 mm (SD 0.19) for the standard group. The difference was statistically significant (p = 0.0184). From the pattern of penetration it was possible to discriminate creep from wear. Most (95%) of the creep occurred within six months of implantation and nearly all within the first year. There was no difference in the mean degree of creep between the two types of polyethylene (highly cross-linked polyethylene 0.26 mm, SD 0.17; standard 0.27 mm, SD 0.2; p = 0.83). There was, however, a significant difference (p = 0.012) in the mean wear rate (highly cross-linked polyethylene 0.03 mm/yr, SD 0.06; standard 0.07 mm/yr, SD 0.05). Creep and wear occurred in significantly different directions (p = 0.01); creep was predominantly proximal whereas wear was anterior, proximal and medial.

We conclude that penetration in the first six months is creep-dominated, but after one year virtually all penetration is due to wear. Highly cross-linked polyethylene has a 60% lower rate of wear than standard polyethylene and therefore will probably perform better in the long term.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 166 - 166
1 Mar 2008
Hauptfleisch J Glyn-Jones S Gill H McLardy-Smith P Murray D
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The Charnley Elite femoral component was first introduced in 1992 as a new design variant of the original Charnley femoral component (De Puy, Leeds, UK) with modified neck and stem geometry. The original component had undergone few changes in nearly forty years and has excellent long-term results. Early migration of the new stem design was determined by Roentgen Stereophotogrammetric Analysis (RSA)1. Rapid early migration of a component relative to the bone, measured by RSA, is predictive of subsequent aseptic loosening for a number of femoral stems. As there was rapid early migration and rotation of the Charnley Elite stem, we predicted that the long-term results would be poor. An outcome assessment is indicated as stems of this type are still being implanted.

One hundred Charnley Elite stems, implanted in our centre between 1994 and 1997 were included in a prospective, cross-sectional follow-up study. Outcome measures include validated clinical scores (Charnley hip score, Harris hip score and Oxford hip score) and radiological scores (Gruen classification) as well as revision rates over the past 10 years.

The clinical follow-up supports the RSA predictions of early failure of the Charnley Elite femoral stem.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 368 - 368
1 Oct 2006
Gill H Polgar K Glyn-Jones S McLardy-Smith P Murray D
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Introduction: The design philosophy of polished tapered THR stems, such as the Exeter, intend for them to migrate distally within the cement mantle. In addition it is likely that micromotion occurs as a result of functional activity. The pattern of induced stresses will be a function of stem geometry & surface finish, as well as applied loading. Aim: To investigate the stresses induced in the cement mantle of a polished tapered THR stem during functional activity.

Method: Using Roentgen Stereophotogrammetric Analysis (RSA) dynamically induced micro-motion (DIMM) was measured in 21 patients implanted with Exeter stems. DIMM was measured as the difference in stem position in going from double to single leg stance on the operated limb. All subjects were measured 3 months post-operatively. A finite element (FE) model of the femur, including all muscles was used to investigate the stress distribution within the cement; contact was modelled with sliding elements allowing separation. The model was validated by comparison to the DIMM measurements.

Results: The Exeter stem demonstrated significant DIMM(p < 0.017), the average motions are given in the table below. The FE model, with sliding contacts was able to predict similar distal migration of the head. The peak minimum principal stress in the mantle was approx 33MPa and occurred in the proximal medial region. Movements occurred at the stem/cement interface.

Discussion and Conclusion: It is possible to measure DIMM in the Exeter stem and combining this with FE modelling the mechanism of stress transfer between the stem and mantle can be investigated in a manner that can be validated.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 45 - 45
1 Mar 2006
Glyn-Jones S Gill R McLardy-Smith P Murray D
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Introduction Polyethylene wear debris is an important cause of failure in cemented total hip arthroplasty. As a result of the biological response to debris at the bone-cement interface, osteolysis and subsequent failure occurs in both femoral and acetabular components. Most acetabular components and liners are made of ultra high molecular weight polyethylene (UHMWPE). Cross-linking UHMWPE has been shown to significantly reduce abrasive wear in hip simulator studies. The wear rates measured in vitro do not always correlate with the wear rates measured in clinical studies[1]. Some new polyethylenes have shown catastrophic wear in clinical studies despite encouraging hip simulator study results[2]. The aim of this study was to compare the wear of standard UHMWPE to that of cross-linked UHMWPE (Longevity, Zimmer, Warsaw, USA)

Patients and Methods This was a prospective, double blind, randomised control trial. 50 subjects were recruited, all of whom received the cemented CPT stem and uncemented Trilogy liner (Zimmer, UK). Subjects were randomised to receive either a standard Trilogy liner or a Longevity liner at the time of operation. Both liners are identical in appearance. All liners were of a neutral configuration. RSA was used to measure linear wear. This was calculated by measuring the distance between the centre of the femoral head and the centre of the acetabular liner. The preliminary results of the study are presented.

Results Both groups underwent significant wear over two years. The two year linear wear of the cross-linked UHMWPE was 0.3mm (+/− 0.06mm, p< 0.001). The two year linear wear of the standard UHMWPE was 0.39mm (+/− 0.04mm, p< 0.001). No significant difference existed between the two groups (p=0.24). Both cohorts had around 0.15 to 0.2 mm of measured wear per year. Cross-linked UHMWPE therefore underwent less wear than standard UHMWPE at two years, however this difference was not statistically significant.

Discussion This study suggests that Longevity UHMWPE has similar wear properties to standard UHMWPE in the first two years following implantation. This does not correlate with in vitro hip simulator studies of Longevity polyethylene, which show a significantly lower wear rate than standard UHMWPE. It suggests that hip simulator studies may be of little value in predicting in vivo wear rates and that all new types of polyethylene should be evaluated clinically and radiologically prior to general release. Whether both cohorts continue to wear at similar rates will only be revealed through continued observation.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 73 - 73
1 Mar 2006
Hauptfleisch J Glyn-Jones S Beard D Gill H McLardy-Smith P Murray D
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Introduction: The Charnley Elite femoral component was first introduced in 1992 as a new design variant of the original Charnley femoral component (De Puy, Leeds, UK) with modified neck and stem geometry. The original component had undergone few changes in nearly forty years and has excellent long-term results.

Early migration of the new stem design was determined by Roentgen Stereophotogrammetric Analysis (RSA). Rapid early migration of a component relative to the bone, measured by RSA, is predictive of subsequent aseptic loosening for a number of femoral stems. As there was rapid early migration and rotation of the Charnley Elite stem, we predicted that the long-term results would be poor. An outcome assessment is required as stems of this type are still being implanted.

Materials and method: One hundred Charnley Elite stems, implanted in our centre between 1994 and 1997 were included in a prospective, cross-sectional follow-up study. Outcome measures include validated clinical scores (Charnley hip score, Harris hip score and Oxford hip score) and radiological scores (Gruen classification) as well as revision rates over the past 10 years.

Results: The preliminary analysis results are given. The mean time to follow-up was 8.28 years. 20 patients have died due to causes unrelated to their operations. 10 patients had stem revisions: 9 for aseptic loosening and 1 for a peri-prosthetic fracture. This indicates a significant 10% failure rate of the prosthesis in less than 10 years.

Preliminary clinical scores in the patients who had not undergone any subsequent surgery were adequate (Oxford Hip Score mean average of 23.9).

Thirteen percent of radiographs analysed had evidence of loosening, giving an overall loosening rate of 14% at 8 years.

Discussion and conclusion: The clinical follow-up supports the RSA predictions of early failure of the Charnley Elite femoral stem.


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 2 | Pages 179 - 183
1 Feb 2006
Hauptfleisch J Glyn-Jones S Beard DJ Gill HS Murray DW

We performed a clinical and radiological study to determine the rate of failure of the Charnley Elite-Plus femoral component. Our aim was to confirm or refute the predictions of a previous roentgen stereophotogrammetric analysis study in which 20% of the Charnley Elite-Plus stems had shown rapid posterior head migration. It was predicted that this device would have a high early rate of failure.

We examined 118 patients at a mean of nine years after hip replacement, including the 19 patients from the original roentgen stereophotogrammetric study. The number of revision procedures was recorded and clinical and radiological examinations were performed.

The rate of survival of the femoral stems at ten years was 83% when revision alone was considered to be a failure. It decreased to 59% when a radiologically loose stem was also considered to be a failure. All the patients previously shown in the roentgen stereophotogrammetric study to have high posterior head migration went on to failure. There was a highly significant difference (p = 0.002) in posterior head migration measured at two years after operation between failed and non-failed femoral stems, but there was no significant difference in subsidence between these two groups.

Our study has shown that the Charnley Elite-Plus femoral component has an unacceptably high rate of failure. It confirms that early evaluation of new components is important and that roentgen stereophotogrammetric is a good tool for this. Our findings have also shown that rapid posterior head migration is predictive of premature loosening and a better predictor than subsidence.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 224 - 224
1 Sep 2005
Glyn-Jones S Gill H McLardy-Smith P Murray D
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Introduction: The Birmingham Hip Resurfacing (BHR) is a metal on metal prosthesis with no published independent clinical studies. It is increasingly used as an alternative to stemmed prostheses in younger patients.

This study presents the 2 year migration results of the BHR femoral component using Roentgen Stereophoto-grammteric Analysis (RSA).

Methods: 26 hips in 24 subjects underwent a BHR, through the postero-lateral approach using CMW3G cement. RSA marker balls were placed in the cortical bone of the femur intra-operatively. The femoral component migration was measured at intervals of 3, 6, 12 and 24 months postoperatively using the Oxford RSA system. The implants were un-modified, geometric algorithms were used to identify the femoral component.

Results: The BHR femoral component showed no significant displacement from its immediate post-operative position. All components of migration showed no significant displacement in any direction, at 1 or 2 years.

Conclusion: The BHR femoral component does not migrate significantly within the first two post-operative years. Its’ migration compares favourably to other designs of femoral component. The BHR is therefore likely to remain stable in the future, as the majority of implant migration occurs within the first two years.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 7 | Pages 921 - 927
1 Jul 2005
Glyn-Jones S Gill HS Beard DJ McLardy-Smith P Murray DW

Polished, tapered stems are now widely used for cemented total hip replacement and many such designs have been introduced. However, a change in stem geometry may have a profound influence on stability. Stems with a wide, rectangular proximal section may be more stable than those which are narrower proximally. We examined the influence of proximal geometry on stability by comparing the two-year migration of the Exeter stem with a more recent design, the CPS-Plus, which has a wider shoulder and a more rectangular cross-section. The hypothesis was that these design features would increase rotational stability.

Both stems subsided approximately 1 mm relative to the femur during the first two years after implantation. The Exeter stem was found to rotate into valgus (mean 0.2°, sd 0.42°) and internally rotate (mean 1.28°, sd 0.99°). The CPS-Plus showed no significant valgus rotation (mean 0.2°, sd 0.42°) or internal rotation (mean −0.03°, sd 0.75°). A wider, more rectangular cross-section improves rotational stability and may have a better long-term outcome.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_IV | Pages 403 - 403
1 Apr 2004
Glyn-Jones S Gill H Murray D
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Introduction: This study investigates the influence of surgical approach on the early migration of a cemented Total Hip Replacement (THR), assessed by Roentgen Stereo-photogrammetric Analysis (RSA). Rapid early migration has been correlated with premature implant failure.

Method: 46 patients awaiting THR were allocated into Posterior Approach (PA) and Lateral Approach (LA) groups. RSA was used to assess post-operative stem position and migration at 1 year. Post-operative gait was examined for a subgroup of patients.

Results: There was no difference in initial stem position within the medulla. Significant differences in distal migration were found; (LA 0.78±0.07mm and PA 1.27±0.15mm), p< 0.01. Posterior head migration for the PA group (0.78±0.18mm) was twice that for the LA group (0.46±0.08mm), p< 0.05. The PA group showed greater medial migration of the prosthesis tip (0.62±0.24mm), compared to the LA group (0.11±0.08mm), p< 0.05. During gait, the legs of the PA group were relatively internally rotated when compared to those of the LA group.

Discussion: The PA implants rotate internally and into valgus further than the LA implants. The starting positions of the prostheses were the same with similar cement and prostheses characteristics. We can infer that surgical approach and therefore muscle function have a significant effect upon component migration. During gait, the PA group has relatively internally rotated legs, probably due to short external rotator weakness. Hence, the internally rotating torque on the femoral stem will be larger, explaining the rapid migration in this direction. With the LA approach, the abductors are likely to be damaged. Therefore, the PA joint reaction force will be more laterally directed, explaining the higher coronal plane rotation rates seen in this group.

Conclusion: Profound differences exist in early migration, between the LA and PA. Different muscle function may account for this and probably influences long-term outcome.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 260 - 261
1 Mar 2004
Glyn-Jones S Gill H McLardy-Smith P Murray D
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Aim: Small amounts of subsidence may be beneficial in stabilising a stem & appears to be a featue of polished tapered stems. Stem rotation (measured as posterior head migration) within the cement mantle, however, is probably a more important mechanism of failure than subsidence. Stems with a wider proximal portion are thought to better resist rotation. The CPS (Endoplus, UK) is such a device; here we compare its’ stability with that of the Exeter (Stryker-Howmedica, UK). Method: 20 patients received the CPS-plus stem & underwent RSA examinations at 3, 6 & 12 months postoperatively. The Exeter 1 year migration data (32 hips) was used as a comparison. Both groups underwent a Hardinge approach & the prosthesis was secured with CMW3G cement. Results: Both stems subsided about 1mm. The CPS showed less medio-lateral & A-P movement of the proximal stem than the Exeter over 1 year, as shown below: 1 Year Mean Migration ± SEM (mm) Discussion: The CPS internally rotates less than the Exeter, as demonstrated by the smaller amount of posterior head migration. It has a lateral flare of the shoulder; making its’ cross-section wider than the Exeter’s, this probably produces a greater resistance to rotation. The CPS also undergoes less medio-lateral proximal stem migration. Its’ lateral shoulder flare is probably responsible for this axial subsidence, as it prevents the shoulder from moving laterally whilst subsiding onto the calcar.

Increasing the width of the proximal section of a polished tapered stem enhances its rotational stability.


The Journal of Bone & Joint Surgery British Volume
Vol. 86-B, Issue 2 | Pages 172 - 176
1 Mar 2004
Glyn-Jones S Gill HS McLardy-Smith P Murray DW

The Birmingham hip resurfacing (BHR) arthroplasty is a metal-on-metal prosthesis for which no medium- or long-term results have been published. Despite this, it is increasing in popularity as an alternative to stemmed prostheses for younger patients. Since the fixation of the socket is conventional, the major concern is long-term failure of the femoral component. This can be predicted by the use of roentgen stereophotogrammetric analysis (RSA). We have therefore undertaken such a study of the BHR femoral component over a period of two years.

Twenty patients (22 hips) underwent a standard BHR procedure. Migration of the femoral component was measured by RSA at intervals of three, six, 12 and 24 months. At 24 months the total three-dimensional migration of the head was 0.2 mm. This was not statistically significant. Previous studies have shown that implants which loosen quickly have rapid early migration. Our results therefore suggest that the BHR femoral component is an inherently stable device which is likely to perform well in the long term.