Aims

To examine incidence of complications associated with outpatient total hip arthroplasty (THA), and to see if medical comorbidities are associated with complications or extended length of stay.

Objectives

The diagnosis of periprosthetic joint infection (PJI) is difficult and requires a battery of tests and clinical findings. The purpose of this review is to summarize all current evidence for common and new serum biomarkers utilized in the diagnosis of PJI.

Aims

This study sought to establish the prevalence of the cross over sign (COS) and posterior wall sign (PWS) in relation to the anterior pelvic plane (APP) in an asymptomatic population through reliable and accurate 3D-CT based assessment.

Aims

We present the ten-year data of a cohort of patients, aged between 18 and 65 years (mean age 52.7 years; 19 to 64), who underwent total hip arthroplasty. Patients were randomised to be treated with a cobalt-chrome (CoCr) femoral head with an ultra-high molecular weight polyethylene (UHMWPE), highly cross-linked polyethylene (XLPE) or ceramic-on-ceramic (CoC) bearing surface.

Aims

The number of patients undergoing arthroscopic surgery of the hip has increased significantly during the past decade. It has now become an established technique for the treatment of many intra- and extra-articular conditions affecting the hip. However, it has a steep learning curve and is not without the risk of complications. The purpose of this systematic review was to determine the prevalence of complications during and following this procedure.

Aims

The Corail stem has good long-term results. After four years of using this stem, we have detected a small group of patients who have presented with symptomatic metaphyseal debonding. The aim of this study was to quantify the incidence of this complication, to delineate the characteristics of patients presenting with this complication and to compare these patients with asymptomatic controls to determine any important predisposing factors.

Aims

The aim of this study was to examine the efficacy and safety of multiple boluses of intravenous (IV) tranexamic acid (TXA) on the hidden blood loss (HBL) and inflammatory response following primary total hip arthroplasty (THA).

Aims

The aims of the study were to review and analyse the reported series of debridement, antibiotics and implant retention (DAIR) in the management of infected total hip arthroplasties (THAs) to establish the overall success and the influencing factors.

Aims

We report the incidence of radiolucent lines (RLLs) using two flanged acetabular components at total hip arthroplasty (THA) and the effect of the Rim Cutter.

Aims

Our aim in this study was to describe a continuing review of 11 total hip arthroplasties using 22.225 mm Alumina ceramic femoral heads on a Charnley flanged femoral component, articulating against a silane crosslinked polyethylene.

Aims

We sought to determine whether cobalt-chromium alloy (CoCr) femoral stem tapers (trunnions) wear more than titanium (Ti) alloy stem tapers (trunnions) when used in a large diameter (LD) metal-on-metal (MoM) hip arthroplasty system.

Aims

This paper describes the methodology, validation and reliability of a new computer-assisted method which uses models of the patient’s bones and the components to measure their migration and polyethylene wear from radiographs after total hip arthroplasty (THA).

Aims

The primary aim of this independent prospective randomised trial was to compare serum metal ion levels for ceramic-on-metal (CoM) and metal-on-metal (MoM) bearing surfaces in total hip arthroplasty (THA). Our one-year results demonstrated elevation in metal ion levels above baseline with no significant difference between the CoM and MoM groups. This paper reviews the five-year data.

Aims

Tantalum (Ta) trabecular metal components are increasingly used to reconstruct major bone defects in revision arthroplasty surgery. It is known that some metals such as silver have antibacterial properties. Recent reports have raised the question regarding whether Ta components are protective against infection in revision surgery. This laboratory study aimed to establish whether Ta has intrinsic antibacterial properties against planktonic bacteria, or the ability to inhibit biofilm formation.

Aims

Our aim was to evaluate the radiographic characteristics of patients undergoing total hip arthroplasty (THA) for the potential of posterior bony impingement using CT simulations.

Objectives

The determination of the volumetric polyethylene wear on explanted material requires complicated equipment, which is not available in many research institutions. Our aim in this study was to present and validate a method that only requires a set of polyetheretherketone balls and a laboratory balance to determine wear.

Aims

To determine whether there is any association between glomerular filtration rate (GFR) and blood cobalt (Co) and chromium (Cr) levels in patients with metal-on-metal (MoM) hip arthroplasty.

Objectives

The National Hip Fracture Database (NHFD) publishes hospital-level risk-adjusted mortality rates following hip fracture surgery in England, Wales and Northern Ireland. The performance of the risk model used by the NHFD was compared with the widely-used Nottingham Hip Fracture Score.

Aims

Ceramic-on-ceramic (CoC) bearings in total hip arthroplasty (THA) are commonly used, but concerns exist regarding ceramic fracture. This study aims to report the risk of revision for fracture of modern CoC bearings and identify factors that might influence this risk, using data from the National Joint Registry (NJR) for England, Wales, Northern Ireland and the Isle of Man.

Objectives

The objective of this study was to assess all evidence comparing the Thompson monoblock hemiarthroplasty with modular unipolar implants for patients requiring hemiarthroplasty of the hip with respect to mortality and complications.

Aims

The aim of this study was to assess the reproducibility and validity of cross table radiographs for measuring the anteversion of the acetabular component after total hip arthroplasty (THA) and to compare it with measurements using CT scans.

Aims

To determine the outcomes following revision surgery of metal-on-metal hip arthroplasties (MoMHA) performed for adverse reactions to metal debris (ARMD), and to identify factors predictive of re-revision.

Objectives

The purpose of this study was to evaluate the existing literature from 2005 to 2016 reporting on the efficacy of surgical management of patients with femoroacetabular impingement (FAI) secondary to slipped capital femoral epiphysis (SCFE).

Objectives

Few studies have assessed outcomes following non-metal-on-metal hip arthroplasty (non-MoMHA) revision surgery performed for adverse reactions to metal debris (ARMD). We assessed outcomes following non-MoMHA revision surgery performed for ARMD, and identified predictors of re-revision.

Objectives

The injured anterior cruciate ligament (ACL) is thought to exhibit an impaired healing response, and attempts at surgical repair have not been successful. Connective tissue growth factor (CTGF) is reported to be associated with wound healing, probably through transforming growth factor beta 1 (TGF-β1).

Aims

The aim of this study was to compare the incidence of aseptic loosening after the use of a cemented acetabular component and a Trabecular Metal (TM) acetabular component (Zimmer Inc., Warsaw, Indiana) at acetabular revision with bone impaction grafting.

Aims

A contact patch to rim (CPR) distance of < 10 mm has been associated with edge-loading and excessive wear. However, not all arthroplasties with a low CPR distance show problems with wear. Therefore, CPR distance may not be the only variable affecting the post-operative metal ion concentrations.

Aims

There is no consensus about the best method of achieving equal leg lengths at total hip arthroplasty (THA) in patients with Crowe type-IV developmental dysplasia of the hip (DDH). We reviewed our experience of a consecutive series of patients who underwent THA for this indication.

Several implants have a proven track record of durability and function in patients over many years. As manufacturers' patents expire it is understandable that cheaper generic copies would be considered. There is currently no established, independent method of determining design equivalence between generic and branded orthopaedic implants.

We acquired 10 boxed, as manufactured components consisting of the generic OptiStem XTR model (n=5) and branded Exeter (n=5) femoral stems. Two examiners were blinded to the implant design and independently measured the mass, volume, trunnion surface topography, roughness, trunnion cone angle, CCD angle and femoral offset using peer-reviewed methods. We then compared the stems using these parameters.

We found that the OptiStems (1) were lighter (p<0.001) (2) had a rougher trunnion surface (p<0.001) with a greater spacing and depth of the machined threads (p<0.001), (3) had greater trunnion cone angles (p=0.007) and (4) a smaller radius at the top of the trunnion (p=0.007). There was no difference for stem volume (p=0.643), CCD angle (p=0.788) or offset (p=0.993).

This study is the first independent investigation of the equivalence of a generic orthopaedic implant to its branded design. We found a clear difference in trunnion roughness, trunnion cone angle and radius, and implant mass when comparing the two generic and branded stem designs. All implants require standard regulatory processes to be followed. It does not appear feasible that generic implants can be manufactured to predictability guarantee the same performance as generic drugs.

We found a number of physical differences between the generic and branded implants. Whilst both designs are likely to work in clinical practice, they are different.

Femoral offset restoration is related to low rates of wear and dislocation. Replication of the native hip anatomy improves prosthesis survival, whereas increasing the femoral offset elevates the torque stresses, thus inducing a risk of suboptimal stem fixation.

Although the Corail (DePuy Synthes, St Priest, France) uncemented stem has an excellent record of fixation, an unexpectedly number of aseptic loosenings has been noted in our institution.

We sought to characterize the clinical parameters observed in a group of patients who have experienced metaphyseal aseptic loosenings with the collarless version of the Corail uncemented femoral component; describe the radiographic findings in this group of patients; expose the intraoperative findings in the cases that needed revision surgery and to calculate a possible frequency of this complication.

We present a series of 15 metaphyseal debondings of the collarless version of the Corail uncemented stem in primary total hip arthroplasty. Eleven men and four woman with an average age of 60 years old (range: 42 to 81 years old) and a previous history of osteoarthritis presented with thigh pain and limping at an average of 33 months postoperative (range: 5 to 100 months). Seven cases presented a Dorr´s classification type A femur and 8 cases a type B femur. In 10 of the 15 cases a 36 mm ceramic on ceramic bearing surface was implanted and in 5 a 28 mm diameter ceramic on polyethylene pair. Radiographic assessment of the failures evidenced an increase in femoral offset of 6.2 mm in average (range: 0 to 17 mm). Nine of the 15 cases had a standard offset stem and 3 an extended offset stem. Leg length discrepancy was in average 2.4 mm (range: 0 to 8 mm). None of the failures presented a more than 2 mm subsidence. Alignment of these stems was in average 2.1 degrees of varus (range: 0 to 5 degrees).

Six cases were revised to a long cemented or uncemented stem, 2 cases were lost and 7 cases are awaiting revision surgery. Although the incidence of this complication was low (15 failures in 855 cases in 10 years = 1.75%), we are concerned about the real magnitude of this problem, as this mode of failure was observed up to 8 years after implantation.

Enhanced lateralization of the hip, independently of the type of stem, may have played a role in the infrequent early failures of this popular design. Routine use of “fine tunning” preoperative planning in order to avoid offset enhancement is strongly reccommended, as this was the only suspected factor that was present in almost all the failures we observed.

The aims of the study were primarily to establish the overall success of debridement, antibiotics and implant retention (DAIR) in the management of infected total hip replacements (THRs) and secondarily to identify risk factors for failure.

Using a standardised and recognised study protocol (“Meta-analysis of observational studies in epidemiology (MOOSE) guidelines) a systematic review and meta-analysis of the literature was performed. The primary outcome measure of interest was treatment success. The search strategy and inclusion criteria plus quality assessment yielded 39 articles eligible for analysis.

The proportion of success from the literature following DAIR in the management of infected THRs is improving over time – the pooled mean proportion of success is 84.5% in studies from 2011–15. There was improved success with early debridement (75.7%) compared with delayed debridement (48.1%) (p=0.006).

The reported outcomes following DAIR appear to be improving with time. One of the most influential determinants of outcome is timing of debridement from onset of symptoms.

Surgeons should have a low threshold for investigating deep infection when presented with an acutely symptomatic THR and be aware of the updated reported outcomes associated with DAIR when considering management options.

Dual mobility (DM) cups are designed to improve stability, however have been associated with increased risk of impingement that can ultimately result in intraprosthetic dislocation. It is speculated that the femoral neck plays a role in their performance. We investigated the effect of neck topography on the wear of new-generation liners.

This was a retrieval study involving 70 DM cups implanted with liners made of highly crosslinked polyethylene and paired with two neck types: either highly polished (n=35) or rough necks (n=35). The median time of implantation was 30 months.

The rim edge of all inserts was investigated by two examiners for evidence of contact with the femoral neck, presenting as deformation of the polyethylene. A high precision roundness machine and micro-CT scans of the components were used to measure the size of the deformations observed.

28 of the 35 (80%) DM liners paired with rougher necks had evidence of neck impingement resulting in a raised lip, whilst 8 out of 35 (23%) liners paired with smooth necks had a raised lip; this difference was significant (p<0.0001). The repeatability and the inter-observer reproducibility of the deformation scores was found to be substantial κ >0.70. The height of the raised rims of the DM cups paired with rough necks had a median (range) of 139 µm (72–255), whilst had a median (range) of 52 µm (45–90) with smooth necks, the difference between the groups was significant (p<0.0001).

Liner rim deformation resulting from contact with the femoral neck likely begins during early in-vivo function.

Rough necks can increase the damage on the polyethylene rim in dual-mobility bearing, which may lead to loss of the retentive power of these components over time.

Outcomes for patients with acute illnesses may be affected by the day of the week they present to hospital. Policy makers state this ‘weekend effect’ to be the main reason for pursuing a change in consultant weekend working patterns. However, it is uncertain whether such a phenomenon exists for elective orthopaedic surgery.

This study investigated whether a ‘weekend effect’ contributed to adverse outcomes in patients undergoing elective hip and knee replacements.

Retrospectively collected data was obtained from our institutions electronic patient records. Using univariate analysis, we examined potential risk factors including; Age, Sex, ASA Grade, Comorbidities, as well as the day of the week, hospital admission and surgery occurred. Subsequent multivariate analyses identified covariate- adjusted risk factors, associated with prolonged hospital stays. 30-day mortality data was assessed according to the day of the week surgery was performed.

892 patients underwent arthroplasty surgery from 01/09/2014 till the 31/08/2015. 457 patients had a total hip and 435 had a total knee replacement. 814 patients (91.3%) underwent surgery during the week, while 78 (8.7%) had surgery on a Saturday. There was no difference in the average Length of Stay (LOS) between groups (5.0, 2.6 versus 5.0, 3.4, p=0.95), and weekend surgery was not associated with a LOS greater than 4 days. The two variables found to be associated with a prolonged LOS were; increasing age (RR) 1.02 (95% CI: 1.01–1.03, p<0.001) and an ASA score of 2, (RR) 1.6 (95% CI: 1.15 − 2.20, p=0.005). There was one death in a patient who was ASA III, and who underwent surgery on a Monday.

There is no ‘weekend effect’ for elective orthopaedic surgery. Changes in consultant weekend working patterns are unlikely to have any effect on mortality or LOS for elective orthopaedic patients.

This study utilized data from the NJR dataset on all Corail/Pinnacle total hip replacements (THR) to determine (a) the level of unit variation of the Corail/Pinnacle 36mm Metal On Metal THR within England and Wales; (b) patient, implant and surgeon factors that may be associated with higher revision rates; (c) Account for the influence of the MHRA announcement in 2010.

The national Revision Rate (RR) for the Corail / Pinnacle MOM THR was 10.77% (OR:1.46; CI:1.17–1.81). This was significantly greater than other articulation combinations (MOP 1.72%, COP 1.36%, COC 2.19%).

The 2010 MHRA announcement did not increase rate of revision (X²=1649.63, df=13, p<.001).

Patient factors associated with significantly increased revision rates included, female gender (OR 1.38 (CI 1.17–1.63, p<.001) and younger age OR 0.99 (CI 0.98–0.99), p<.001). Implant factor analysis demonstrated an inverse relationship between cup size and revision. As head length increased RR increased – highest risk of revision +12.5 (OR 1.69 (CI 1.12–2.55), p=0.13). Coxa vara, high offset stems had a higher risk of revision compared to standard offset stems (OR:1.41 (CI 1.15–1.74; p<.001). As stem size increased risk of revision decreased (OR 0.89 (CI 0.85–0.93); p<.001). Surgeon grade did not influence RR.

There was significant variation in RR between hospitals with 7 units (7/61 excluding low volume centres, <50 implants) identified as having significant higher rates of revision. However, for each of these units there was a greater proportion of higher risk patients (female, cup size 50–54, stem type).

This study has provided insight into unit variation, risk factors and the long term outcome of the Corail/Pinnacle 36mm MOMTHR. Future aims are to use these results to develop a risk stratified algorithm for the long term follow of these patients to minimize patient inconvenience and excess use of limited NHS resources.

We compared the long-term clinical and radiological results of hybrid total hip replacement (THR) with metal-on-metal Birmingham hip resurfacing (BHR) in two groups of 54 young patients matched for age, gender, body mass index and pre-operative levels of activity.

The clinical outcome was assessed by the University of California, Los Angeles (UCLA) activity score, the Oxford Hip Score (OHS) and the EuroQol scores. Radiologically, all hips were assessed for migration and osteolysis, the hybrid THRs for polyethylene wear and the BHRs for a pedestal sign.

The mean follow-up of the patients with a hybrid THR was 16 years and for those with a BHR, 15 years. 12 patients with a hybrid THR and 6 with a BHR had died. 2 patients with a BHR refused follow up but remain unrevised and 5 were lost to follow-up, as was 1 with a hybrid THR. The revision rate of the hybrid THRs was 28% (15 of 54) and of the BHRs 11% (6 of 54) (p = 0.029). Radiographs of a further 13 hybrid THRs demonstrated wear and osteolysis but are functioning well and are under observation. Of the unrevised BHRs 96% had radiological changes, of which approximately 17% had progressed over the previous 6 years. All hybrid THRs demonstrated linear polyethylene wear with a mean of 1.84mm (0.06 to 2.6). The BHRs recorded superior OHS (p = 0.03), UCLA (p = 0.0096), and EuroQol visual analogue scores (p = 0.03).

After 15 years, patients with BHRs remained more active and had a lower rate of revision and death than those with hybrid THRs. Both groups demonstrated progressive radiological changes at long-term follow-up.

Aims

To determine the effect of a change in design of a cementless ceramic acetabular component in fixation and clinical outcome after total hip arthroplasty

Research into the treatment of Femoro-Acetabular Impingement (FAI) has focussed on surgical correction of structural abnormalities and tended to overlook the dynamic process of impingement. The role of Physiotherapy in addressing abnormal hip movement and any resulting effect on the symptoms of FAI remains untested. A pilot study was therefore instigated to evaluate the effect of physiotherapy on pain and function in patients with FAI.

30 adults aged between 18 and 50 years with a diagnosis of symptomatic FAI were recruited. 23 (77%) completed the study.

Intervention was 3 months of specialist physiotherapy focused on improving pelvic and proximal femoral control. The control group received routine care.

All functional outcomes improved in the Physiotherapy group and this included improvement beyond minimal clinically important difference and measurement error on the Hip Outcome Score.

There was marginal improvement in pain in both groups

Results suggest that physiotherapy treatment can improve function in adults with symptomatic FAI. Larger studies are needed to evaluate the role of conservative management in FAI.

Numerous studies have evidenced cement-in-cement techniques as reliable in revision arthroplasty. The original cement mantle is commonly reshaped to aid accurate placement of the new stem.

Ultrasonic devices selectively remove cement, preserve host bone and have lower cortical perforation rates than other techniques. As far as the authors are aware, their impact on final cement-cement bonds has not been investigated. This study assessed the impact of cement removal using OSCAR (Orthosonics System for Cemented Arthroplasty Revision, ORTHOSONICS) on final cement-cement bonds.

Twenty-four specimens were manufactured by pouring cement (Simplex P Bone Cement, Stryker) into stainless-steel moulds with a central rod polished to Stryker Exeter V40 specifications. After cement curing, rods were removed and eight specimens allocated to each of three internal surface preparation groups: 1) burr; 2) OSCAR; or 3) no treatment. Internal holes were re-cemented, then each specimen was cut into 5mm discs. Shear testing of discs was completed by a technician blinded to original grouping (Instron 5567, UK), recording ultimate shear strengths.

The mean shear strength for OSCAR-prepared specimens (17 MPa, 99% CI 14.9 to 18.6, SD=4.0) was significantly lower than that measured for the control (23 MPa, 99% CI 22.5 to 23.7, SD=1.4) and burr (23 MPa, 99% CI 22.1 to 23.7, SD=1.9) groups (P<0.001, one-way ANOVA with Tukey's post-hoc analysis). There was no significant difference between control and burr groups (P>0.05).

Results show that cement removal technique impacts on final cement-cement bonds. This in vitro study shows a significantly weaker bond when using OSCAR prior to re-cementation into an old cement mantle, compared to cement prepared with a burr or no treatment.

These results have implications for surgical practice and decision-making about specific cement removal techniques used during cement-in-cement revision arthroplasty, suggesting that the risks and benefits of ultrasonic cement removal need careful consideration.

Trunnionosis, due to mechanical wear and/or corrosion at the head stem taper junction, can occur in metal on polyethylene (MOP) hip implants. In some patients this results in severe soft tissue destruction or Adverse Reaction to Metal Debris (ARMD). The amount of material required to cause ARMD is unknown but analyses of retrieved hips may provide the answer to this clinically important question.

We collected implants from 20 patients with failed hips with MOP bearings, revised due to ARMD. We collected clinical, imaging and blood test data. We graded the severity of taper corrosion (1 to 4), and quantified the volume of material loss from this junction. We compared our results with previous data collected for metal-on-metal (MOM) hips.

The median time to revision of the MOP hips was 51.3 (23.1–56.4) months. All head tapers were moderately to severely corroded with a median corrosion score of 4. The median (range) of total material loss at the taper of the MOP hips was 3.9 mm³ (2.96 – 7.85 mm³) and the material loss rate was 1.4 mm³ / year (0.56 – 1.82).

Comparison with MOM hips revealed no significant difference in taper material loss (p=0.7344) with a median rate of 0.81 mm³ / year (0.01–3.45).

We are the first to quantify the volume of material loss at the head taper of hip implants with MOP bearings that were revised due to trunnionosis. This data indicates that a clinically significant dose of cobalt and chromium to induce ARMD is approximately 1.4 mm³ / year.

We have identified a clinically significant volume of taper material loss in MOP hips.

Litigation costs are significant and increasing annually within the National Health Service (NHS) in England.

The aim of this work was to evaluate the burden of successful litigation relating to hip surgery in England. Secondary measures looked at identifying the commonest causes of successful legal action.

A retrospective review was conducted on the National Health Service Litigation Authority (NHSLA) database. All successful claims related to hip surgery over a 10 year period from 2003–2013 were identified. A total of 798 claims were retrieved and analysed.

The total cost of successful claims to the NHS was £66.3 million. This compromised £59 million in damages and £7.3 million in NHS defence-related legal costs. The mean damages for settling a claim were £74,026 (range £197-£1.6million). The commonest cause of claim was post-operative pain with average damages paid in relation to this injury being £99,543. Nerve damage and intra-operative fractures were the next commonest cause of claim with average damages settled at £103,465.

Legal action in relation to hip surgery is a considerable source of cost to the NHS. The complexity of resolving these cases is reflected in the associated legal costs which represent a significant proportion of payouts. With improved understanding of factors instigating successful legal proceedings, physicians can recognise areas where practice and training need to be improved and steps can be taken to minimise complications leading to claims.

Ceramic on ceramic (CoC) bearings in total hip arthroplasty (THA) are commonly used but concerns exist regarding ceramic fracture. This study aims to report the risk of revision for fracture of modern CoC bearings and identify factors that might influence this risk, using data from the National Joint Registry.

We analysed data on 111,681 primary CoC THA's and 182 linked revisions for bearing fracture recorded in the National Joint Registry of England, Wales, Northern Ireland and the Isle of Man (NJR). We used implant codes to identify ceramic bearing composition and generated Kaplan-Meier estimates for implant survivorship. Logistic regression analyses were performed for implant size and patient specific variables to determine any associated risks for revision.

99.8% of bearings were CeramTec Biolox® products. Revisions for fracture were linked to 7 of 79,442 (0.009%) Biolox® Delta heads, 38 of 31,982 (0.119%) Biolox® Forte heads, 101 of 80,170 (0.126%) Biolox® Delta liners and 35 of 31,258 (0.112%) Biolox® Forte liners. Regression analysis of implant size revealed smaller heads had significantly higher odds of fracture (χ2=68.0, p<0.0001). The highest fracture risk were observed in the 28mm Biolox® Forte subgroup (0.382%). There were no fractures in the 40mm head group for either ceramic type. Liner thickness was not predictive of fracture (p=0.67). BMI was independently associated with revision for both head fractures (OR 1.09 per unit increase, p=0.031) and liner fractures (OR 1.06 per unit increase, p=0.006).

We report the largest registry study of CoC bearing fractures to date. Modern CoC bearing fractures are rare events. Fourth generation ceramic heads are around 10 times less likely to fracture than third generation heads, but liner fracture risk remains similar between these generations.

Outcomes following metal-on-metal hip replacement (MoMHR) revision surgery for adverse reactions to metal debris (ARMD) have been poor, and inferior compared with non-ARMD revisions. Subsequently, surgeons and worldwide authorities widely recommended early revision for ARMD, with a lower surgical threshold adopted. However, the impact of early surgery for ARMD is unknown. We compared the rates of adverse outcomes following MoMHR revision surgery in matched ARMD and non-ARMD patients.

We performed a retrospective observational study using data from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man. All MoMHR patients subsequently undergoing revision surgery for any indication between August 2008 and August 2014 were eligible. ARMD and non-ARMD revisions were matched one-to-one for multiple potential confounding factors using propensity scores. Adverse outcomes following revision surgery (intra-operative complications, mortality, re-revision surgery) were compared between matched groups using regression analysis.

In 2,576 matched MoMHR revisions (ARMD=1,288 and non-ARMD=1,288), intra-operative complications were similar between ARMD (2.4%) and non-ARMD (2.5%) revisions (odds ratio=0.97, 95% CI=0.59–1.60; p=0.899). All-cause mortality rates were lower following ARMD revision compared with non-ARMD revision (hazard ratio (HR)=0.43, 95% CI=0.22–0.86; p=0.018). All-cause re-revision rates were lower following ARMD revision compared with non-ARMD revision (HR=0.52, 95% CI=0.36–0.75; p<0.001). Compared with ARMD revision (5-years=94.3%), MoMHR revisions for infection (5-years=81.2%) and dislocation/subluxation (5-years=81.9%) had the lowest implant survival rates.

Contrary to previous observations, MoMHRs revised for ARMD have approximately half the risk of re-revision and death compared to non-ARMD revisions. We suspect worldwide regulatory authorities have positively influenced outcomes following ARMD revision by widely recommending that surgeons exercise a lower revision threshold.

Our findings suggest the threshold for ARMD revision surgery need not be lowered further. The high risk of failure following MoMHR revision for infection and dislocation is concerning.

The risk of dying following total hip replacement (THR) is low and has declined over the last decades. The influence of comorbidities and worse physical status on mortality leads to the idea that patient-reported health status may also be a predictor of mortality. Although this has not been demonstrated in THR surgery, some studies in other fields have reported an association. The aim of this study was to investigate the relationship between patient-reported health status before THR and the risk of dying up to 5 years post-operatively.

The Swedish Hip Arthroplasty Register runs a nationwide PROMs program including the EQ-5D questionnaire to routinely monitor patients undergoing THR in Sweden. For these analyses, we used register data on 42,862 patients with hip osteoarthritis operated with THR between 2008 and 2012. Relative survival ratio was calculated by dividing the observed survival in the patient group by age- and gender-adjusted expected survival of the general population. Multivariable modelling proceeded with time-transformed Cox proportional hazards. Pre-operative responses to the five EQ-5D dimensions along with age, gender, education status, year of surgery, and hospital type were used as independent variables.

As a group THR patients had a better survival than the general population. Broken down by the five EQ-5D dimensions we observed differentiated survival patters. For all dimensions, those reporting moderate problems (level 2) had higher mortality than those reporting no problems (level 1) and those reporting extreme problems (level 3) had higher mortality than those reporting level 1 or 2.

Worse health status according to the EQ-5D before THR is associated with higher mortality up to five years after surgery. The complexity of the interactions between different patient-factors associated with outcomes complicates accurate assessments of risks and expected benefits for individual patients. EQ-5D responses may be useful in a multifactorial individualized risk assessment before THR.

Hip arthroscopy is a rapidly expanding technique that has a steep learning curve. Simulation may have a role in helping trainees overcome this. However there is as yet no validated hip arthroscopy simulator. This study aimed to test the construct validity of a virtual reality hip arthroscopy simulator.

Nineteen orthopaedic surgeons performed a simulated arthroscopic examination of a healthy hip joint in the supine position. Surgeons were categorized as either expert (those who had performed 250 hip arthroscopies or more) or novice (those who had performed fewer than this). Twenty-one targets were visualized within joint; nine via the anterior portal, nine via the anterolateral and three via the posterolateral. This was followed by a task testing basic probe examination of the joint in which a series of eight targets were probed via the anterolateral portal. Each surgeon's performance was evaluated by the simulator using a set of pre-defined metrics including task duration, number of soft tissue & bone collisions, and distance travelled by instruments. No repeat attempts at the tasks were permitted. Construct validity was then evaluated by comparing novice and expert group performance metrics over the two tasks using the Mann–Whitney test, with a p value of less than 0.05 considered significant.

On the visualization task, the expert group outperformed the novice group on time taken (P=0.0003), number of collisions with soft tissue (P=0.001), number of collisions with bone (P=0.002) and distance travelled by the arthroscope (P=0.02). On the probe examination, the two groups differed only in the time taken to complete the task (P=0.025).

Increased experience in hip arthroscopy was reflected by significantly better performance on the VR simulator across two tasks, supporting its construct validity.

This study validates a virtual reality hip arthroscopy simulator and supports its potential for developing basic arthroscopic skills.

Prospectively collected data is an important source of information subjected to change over time. What surgeons were doing in 1999 might not be the case anymore in 2016 and this change in time also applies to a number of factors related to the performance and outcome of total hip replacement. We evaluated the evolution of factors related to the patient, the surgical procedure, socio-economy and various outcome parameters after merging the databases of the Swedish Hip Arthroplasty Register, Statistics Sweden and the National Board of Health and Welfare.

Data on 193,253 THRs (164,113 patients) operated between 1999 and 2012 were merged with databases including general information about the Swedish population and about hospital care. We studied the evolution of surgical volume, patient demographics, socio-economic factors, surgical factors, length of stay, mortality rate, adverse events, re-operation and revision rates and PROMs.

Most patients were operated because of primary osteoarthritis and this share increased further during the period at the expense of decreasing number of patients with inflammatory OA and hip fracture. Comorbidity and ASA scores increased for each year. The share of all cemented implants has dropped from 92% to 68% with a corresponding increase of all uncemented from 2% to 16%.

Length of stay decreased with about 50 percent to 4.5 days in 2012. The 30- and 90-day mortality rate dropped to 0.4% and 0.7%. Re-operation and revision rates at 2 years were lower in the more recent years. The postoperative PROMs are improving despite the preoperative pain scores getting worse.

Even in Sweden, always been considered as a very conservative country with regards to hip replacement surgery, the demographics of the patients, the comorbidities and the primary diagnosis for surgery are changing. Despite these changes the outcomes like mortality, re-operations, revisions and PROMs are improving.

There has been a significant decline in the use of metal-on-metal (MoM) bearings due to concerns regarding adverse reaction to metal debris (ARMD). The Medicines and Healthcare products Regulatory Agency (MHRA) recommends annual follow-up for life with blood Cobalt (Co) and Chromium (Cr) ion level measurement in all MoM THRs with femoral head size greater than or equal to 36mm. We present the serial ten year serum Co and Cr levels in a cohort of large head MoM THRs and analyse the utility of measuring serum ions levels annually.

All patients who underwent unilateral large head MoM THR between January 2004 and December 2006 were included in this prospective study. Annual serum Co and Cr measurements were measured. Clinical case notes and radiographs were reviewed for failure, revision surgery and the occurrence of ARMD. Mann Whitney test was used to analyse changes in serum Co and Cr levels. Receiver Operating Characteristic (ROC) curve was plotted based on their sensitivity and specificity to detect ARMD.

256 patients were included. There was a significant increase in serum ion values in the first two years. After 7 years, there was no significant change in Co values(p=0.78) and there was a decline in Cr value after 9 years(p<0.001). With 7 µg/l as the cut-off value, the sensitivity and specificity of Co was 82.1% and 65.5% and of Cr was 53.5% and 91.3%.

Annual follow-up of patients with MoM THR based on the MHRA guideline to obtain serum metal ion levels can cost about £9 million/year. Our study noted poor discriminatory ability for both Co and Cr values in the ROC curve. There is poor correlation between serum metal ion levels and the occurrence of ARMD on MARS MRI. Based on our results we find limited utility in doing ion levels after 7 years in asymptomatic patients.

Recent studies have demonstrated that implant-specific blood metal ion thresholds exist in unilateral and bilateral metal-on-metal (MoM) hip arthroplasty patients, with these thresholds being most effective for identifying patients at low-risk of adverse reactions to metal debris (ARMD). We investigated whether these new blood metal ion thresholds could effectively identify patients at risk of ARMD in an external cohort of MoM hip arthroplasty patients.

We performed a validation study involving 803 MoM hip arthroplasties implanted in 710 patients at three European centres (323=unilateral Birmingham Hip Resurfacing (BHR); 93=bilateral BHR; 294=unilateral Corail-Pinnacle). All patients underwent whole blood metal ion sampling. Patients were divided into those with ARMD (revised for ARMD or ARMD on imaging; n=75), and those without ARMD (n=635). Previously devised implant-specific blood metal ion thresholds (cobalt=2.15μg/l for unilateral BHR; maximum cobalt or chromium=5.5μg/l for bilateral BHR; cobalt=3.57μg/l for unilateral Corail-Pinnacle) were applied to the validation cohort, with receiver operating characteristic curve analysis used to establish the discriminatory characteristics for each respective threshold.

The area under the curve, sensitivity, specificity, positive predictive value and negative predictive value for distinguishing between patients with and without ARMD for each implant-specific threshold were respectively: unilateral BHR=89.4% (95% CI=82.8%-96.0%), 78.9%, 86.7%, 44.1%, 96.9%; bilateral BHR=89.2% (95% CI=81.3%-97.1%), 70.6%, 86.8%, 54.5%, 93.0%; unilateral Corail-Pinnacle=76.9% (95% CI=63.9%-90.0%), 65.0%, 85.4%, 24.5%, 97.1%. The 7μg/l UK MHRA threshold missed significantly more patients with ARMD compared with the implant-specific thresholds (4.9% vs. 2.8%; p=0.0003).

This external multi-centre validation study has confirmed that MoM hip arthroplasty patients with blood metal ion levels below newly devised implant-specific thresholds have a low-risk of ARMD. Compared to implant-specific thresholds, the currently proposed fixed MHRA threshold missed more patients with ARMD.

We recommend using implant-specific thresholds over fixed thresholds when managing MoM hip arthroplasty patients.

Dual-taper implants provide surgeons with options to optimise patients' anatomy intraoperatively but are at risk of early revision due to adverse tissue reactions to corrosion debris. Risk factors for failure and linkage with symptoms however are not fully understood. We related retrieval findings to clinical and implant variables.

This study involved 88 failed dual-taper implants with TMZF femoral stems and cobalt-chromium necks, revised for pain, elevated Co (median = 7.3μg/L) and Cr (median = 2.15μg/L) ions levels and fluid collection on MRI.

Stem-neck surfaces were assessed for: 1) severity of corrosion using a published visual method and 2) severity of material lost and location of damage with a roundness-measuring machine. Five traces were taken on each round section of the taper surface at 45° increments to compute the relative depth of damage. The total area of these traces provided a measure of surface damage for comparative purposes.

The stem-neck taper junctions were severely corroded; the deepest areas of damage were on the inferior-proximal and superior-distal part of the necks, compatible with cantilever bending. Elemental analysis revealed chromium rich deposits indicative of corrosion processes and metal transfer from the stem to the neck.

There was a positive correlation between the severity of damage and time of implantation (p<0.0001). Co and Cr levels in the blood were also strongly correlated (p<0.0001, p=0.0002). No other implant or patient variables were linked.

The stem-neck junction was severely corroded in all cases. The severity and location of the areas of surface damage did not link with implant or patient characteristics in this big cohort suggesting that the design and material combination is the predominant source of failure in these designs.

Dual-taper hips are severely corroded at the stem-neck junction; this appears to be due to the use of a TMZF alloy stem paired with CoCrMo necks.

Recent studies have reported on non-metal-on-metal hip arthroplasty (non-MoMHA) patients requiring revision surgery for adverse reactions to metal debris (ARMD). Although the outcomes following revision surgery for ARMD in MoMHA patients are known to generally be poor, little evidence exists regarding outcomes following non-MoMHA revision surgery performed for ARMD. We determined the outcomes following non-MoMHA revision surgery performed for ARMD, and identified predictors of re-revision.

We performed a retrospective observational study using data from the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man. All primary non-MoMHA patients who subsequently underwent revision surgery for ARMD between 2008–2014 were included (n=185). Outcome measures following ARMD revision were intraoperative complications, mortality, and re-revision surgery. Predictors of re-revision surgery were identified using Cox regression analysis.

Intra-operative complications occurred in 6.0% (n=11) of ARMD revisions. The cumulative 4-year patient survival rate was 98.2% (95% CI=92.9–99.5%). Re-revision surgery was performed in 13.5% (n=25) of hips at a mean time of 1.2 years (range 0.1–3.1 years) following ARMD revision. Infection (32%), dislocation/subluxation (24%), and aseptic loosening (24%) were the commonest re-revision indications. The cumulative 4-year implant survival rate was 83.8% (95% CI=76.7%-88.9%). Significant predictors of re-revision were: multiple revision indications (Hazard Ratio (HR)=2.78; 95% CI=1.03–7.49; p=0.043), incomplete revision procedures (including modular component exchange only) (HR=5.76; 95% CI=1.28–25.9; p=0.022), and ceramic-on-polyethylene revision bearings (HR=3.08; 95% CI=1.01–9.36; p=0.047).

Non-MoMHA patients undergoing ARMD revision have a high short-term risk of re-revision. Infection, dislocation/subluxation, and aseptic loosening were the commonest re-revision indications. Furthermore, important and potentially modifiable predictors of future re-revision were identified.

Although the poor prognostic factors identified require validation in future studies, our findings may be used to counsel patients about the risks associated with ARMD revision surgery, and guide decisions about the reconstructive procedure.

Aims

The aim of this study was to evaluate the long-term clinical and radiographic outcomes of the Birmingham Interlocking Pelvic Osteotomy (BIPO).

Aims

We conducted a prospective study of a delta ceramic total hip arthroplasty (THA) to determine the rate of ceramic fracture, to characterise post-operative noise, and to evaluate the mid-term results and survivorship.

Objectives

We used the National Joint Registry for England, Wales, Northern Ireland and the Isle of Man (NJR) to investigate the risk of revision due to prosthetic joint infection (PJI) for patients undergoing primary and revision hip arthroplasty, the changes in risk over time, and the overall burden created by PJI.

The definition of osseous instability in radiographic borderline dysplastic hips is difficult. A reliable radiographic tool that aids decision-making specifically, a tool that might be associated with instability-therefore would be very helpful for this group of patients. The aims of this study were:

(1) To compare a new radiographic measurement, which we call the Femoro-Epiphyseal Acetabular Roof (FEAR) index, with the lateral centre-edge angle (LCEA) and acetabular index (AI), with respect to intra- and interobserver reliability; (2) to correlate AI, neck-shaft angle, LCEA, iliocapsularis volume, femoral antetorsion, and FEAR index with the surgical treatment received instable and unstable borderline dysplastic hips; and (3) to assess whether the FEAR index is associated clinical instability in borderline dysplastic hips.

We defined and validated the FEAR index in 10 standardized radiographs of asymptomatic controls using two blinded independent observers. Interrater and intrarater coefficients were calculated, supplemented by Bland-Altman plots. We compared its reliability with LCEA and AI. We performed a case-control study using standardized radiographs of 39 surgically treated symptomatic borderline radiographically dysplastic hips and 20 age-matched controls with asymptomatic hips (a 2:1 ratio), the latter were patients attending our institution for trauma unrelated to their hips but who had standardized pelvic radiographs between January 1, 2016 and March 1, 2016.

Patient demographics were assessed using univariate Wilcoxon two-sample tests. There was no difference in mean age (overall: 31.5 ± 11.8 years [95% CI, 27.7–35.4 years]; stable borderline group: mean, 32.1± 13.3 years [95%CI, 25.5–38.7 years]; unstable borderline group: mean, 31.1 ± 10.7 years [95% CI, 26.2–35.9 years]; p = 0.96) among study groups. Treatment received was either a periacetabular osteotomy (if the hip was unstable) or, for patients with femoroacetabular impingement, either an open or arthroscopic femoroacetabular impingement procedure. The association of received treatment categories with the variables AI, neck-shaft angle, LCEA, iliocapsularis volume, femoral antetorsion, and FEAR index were evaluated first using Wilcoxon two-sample tests (two-sided) followed by stepwise multiple logistic regression analysis to identify the potential associated variables in a combined setting. Sensitivity, specificity, and receiver operator curves were calculated. The primary endpoint was the association between the FEAR index and instability, which we defined as migration of the femoral head either already visible on conventional radiographs or recentering of the head on AP abduction views, a break of Shenton's line, or the appearance of a crescent-shaped accumulation of gadolinium in the posteroinferior joint space at MR arthrography.

The FEAR index showed excellent intra- and interobserver reliability, superior to the AI and LCEA. The FEAR index was lower in the stable borderline group (mean, −2.1 ± 8.4; 95% CI, −6.3 to 2.0) compared with the unstable borderline group (mean, 13.3 ± 15.2; 95% CI, 6.2–20.4) (p < 0.001) and had the highest association with treatment received. A FEAR index less than 5° had a 79% probability of correctly assigning hips as stable and unstable, respectively (sensitivity 78%; specificity 80%).

A painful hip with a LCEA of 25° or less and FEAR index less than 5° is likely to be stable, and in such a situation, the diagnostic focus might more productively be directed toward femoroacetabular impingement.

Circulating cobalt and chromium from metal-on-metal implants cause rare but fatal autopsy-diagnosed cardiotoxicity. Concern exists that milder cardiotoxicity may be common and under-recognized. Unacceptably high failure rates of metal-on-metal hip implants have prompted regulatory authorities to issue worldwide safety alerts. Despite this, approximately 1 million patients continue to live with metal-on-metal implants, putting them at risk of systemic toxicity. Although blood cobalt and chromium levels are easily measured and track local toxicity, no non-invasive tests for organ deposition exist.

We recently demonstrated the utilisation of a T2* protocol (cardiovascular MRI) to detect cobalt and chromium deposition within the liver of a patient with elevated blood cobalt levels (confirmed by liver biopsy tissue analysis and X-ray fluorescence spectroscopy).

We sought to detect and constrain the correlation between blood metal ions and a comprehensive panel of established markers of early cardiotoxicity. In addition we applied T2* protocols with the aim of detecting cardiac metal deposition.

90 patients were recruited through RNOH clinics into this prospective single centre blinded study. Patients were divided into 3 age and gender-matched groups according to type of implant and blood metal ion levels as follows: [Group A] Non-metal bearing hip implants; [Group B] Metal-on-metal implants, low blood metal ion levels (<7ppb); and [Group C] Metal-on-metal implants, high blood levels (>7ppb).

All underwent detailed cardiovascular phenotyping using cardiac MRI (with T2*, T1 and ECV mapping, in addition to LV size and ejection fraction), advanced echocardiography (LV size and ejection fraction), and cardiac blood biomarker (Troponin and BNP) sampling in the same sitting at the Heart Hospital London. Primary outcomes were pre-specified. See study flow diagram – figure 1. (The study was registered with clinicaltrials.gov: NCT02331264).

Blood cobalt levels were significantly different between groups (0.17ppb (range 0·10–0·47, SD 0·08) vs. 2·47 (0·72–6·9, SD 1·81) vs. 30·0 (7·54–118.0, SD 29·1) respectively for groups A, B and C).

No significant between-group differences were found for LV size, ejection fraction (CMR or echocardiography), LA size, T1, T2*, ECV, BNP or troponin, with all results within normal ranges. There was no relationship between blood cobalt levels and either left ventricular ejection fraction or T2* (r=-0·022 and r=-0·108 respectively). Although small, the study was sufficiently powered to detect, as a minimum, a difference in ejection fraction of 4.8% (Cohen's d effect size 0·8).

Using best available technologies, exposure of patients with metal-on-metal hip implants to high (but not extreme) blood cobalt and chromium levels has no detectable effect on the heart. We believe these findings will offer reassurance to one million patients worldwide living with a metal-on-metal hip implant and will support clinicians caring for such patients.

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Unknown femur orientation during X-ray imaging may cause inaccurate radiographic measurements. The aim of this study was to assess the effect of 3D femur orientation during radiographic imaging on the measurement of greater trochanter to femoral head centre (GT-FHC) distance.

Three-dimensional femoral shapes (n=100) of unknown gender were generated using a statistical shape model based on a training data of 47 CT segmented femora. Rotations in the range of 0° internal to 50° external and 50° of flexion to 0° of extension (at 10 degree increments) were applied to each femur. A ray tracing algorithm was then used to create 2D images representing radiographs of the femora in known 3D orientations. The GT-FHC distance was then measured automatically by identifying the femoral head, shaft axis and tip of greater trochanter.

Uniaxial rotations had little impact on the measurement with mean absolute error of 0.6 mm and 3.1 mm for 50° for pure external rotation and 50° pure flexion, respectively. Combined flexion and external rotation yielded more significant errors with 10° around each axis introducing a mean error of 3.6 mm and 20° showing an average error of 8.8 mm (Figure 1.). In the cohort we studied, when the femur was in neutral orientation, the tip of greater trochanter was never below the femoral head centre.

Greater trochanter to femoral head centre measurement was insensitive to rotations around a single axis (i.e. flexion or external rotation). Modest combined rotations caused the tip of greater trochanter to appear more distal in 2D and led to deviation from the true value. This study suggests that a radiograph with the greater trochanter appearing below femoral head centre may have been acquired with 3D rotation of the femur.

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Modular un-cemented acetabular components are used in over 50% of UK hip replacements. Mal-seating of hard liners has been reported as a cause of failure which may be a result of errors in assembly, but also could be affected by deformation of the acetabular shell on insertion. Little information exists on in vivo shell deformation. Previous work has confirmed the importance of shell diameter and thickness upon shell behaviour, but mostly using single measurements in models or cold cadavers.

Exploration of deformation and its relaxation over the first twenty minutes after implantation of eight generic metal cups at body temperature.

Using a previously validated cadaveric model at controlled physiological temperature with standardised surgical technique, we tested the null hypothesis that there was no consistency for time dependent or directional change in deformation for a standard metal shell inserted under controlled conditions into the hip joint. Eight custom made titanium alloy (TiAl6V4) cups were implanted into 4 cadavers (8 hips). Time dependent cup deformation was determined using the previously validated ATOS Triple Scan III (ATOS) optical measurement system. The pattern of change in the shape of the surgically implanted cup was measured at 3 time points after insertion.

We found consistency for quantitative and directional deformation of the shells. There was consistency for relaxation of the deformation with time. Immediate mean change in cup radius was 104μm (sd 32, range 67–153) relaxing to mean 96 μm (sd 32, range 63–150) after 10 minutes and mean 92 μm (sd 28, range 66–138) after 20 minutes.

This work shows the time dependent deformation and relaxation of acetabular titanium shells and may aid determining the optimal time for insertion of the inner liner at surgery.

Tissue sparing hip replacements have recently gained popularity, in an attempt to provide shorter hospital stay, faster recovery time and potentially to reduce morbidity and complications. Direct anterior approaches (DAA) have been shown to allow faster recovery, but also appear to be associated with a higher incidence of complications, especially during the learning curve. Mini-posterior approaches have the advantage of increased familiarity, however may not be maximally muscle sparing.

Prospective and retrospective data was collected following a published protocol. This included patient demographic data, theatre time, units of blood transfused, length of stay, functional scores and radiological parameters. Rates of conversion to posterior approach and complications were also documented.

The results of our first 100 cases completed are presented: Within this initial cohort, three patients suffered major complications: These included an anterior dislocation, which was successfully reduced with closed reduction under general anaesthetic, an early (day 6) periprosthetic fracture, which was successfully revised to a cemented prosthesis, and a case of stem subsidence.

Our results also suggest a learning curve effect, limited to theatre time and blood loss. Complications were evenly distributed throughout the period of study and are of similar frequency to standard approaches.

As the first European centre to adopt the SuperPATH approach, we have shown that the published results from America can be reproduced. In contrast to DAA, the learning curve is not associated with higher rates of femoral fracture and other complications. The fact that the approach is extensile, being the superior part of the posterior approach, allows for all of the advantages of muscle preservation with the safety of potential extension when necessary.

Malnutrition is a potentially modifiable risk factor that may contribute to complications following geriatric hip fracture surgery. The purpose of this study was to investigate the association between preoperative hypoalbuminemia, a marker for malnutrition, and complications during the thirty days following surgery for geriatric hip fracture.

The American College of Surgeons National Surgical Quality Improvement Program was used to conduct a retrospective cohort study of geriatric patients (>65 years) undergoing surgery for hip fracture. Patients without preoperative serum albumin concentration were excluded. Outcomes were compared between patients with and without hypoalbuminemia (defined as serum albumin concentration <3.5g/dL). All comparisons were adjusted for baseline differences between populations.

17,651 Patients were identified. Of these, 8,272 (46.9%) underwent hemiarthroplasty, 759 (4.3%) total joint arthroplasty, 324 (1.9%) percutaneous fixation, 2,445 (13.9%) plate/screw fixation, and 5,833 (33.1%) intramedullary fixation. The prevalence of hypoalbuminemia was 45.9% (Figure 1). The risk for death was strongly associated with serum albumin concentration, with a linear increase in risk observed as albumin fell below 3.5 g/dL (p<0.001; Figure 2). Following adjustment for all demographic, comorbidity, and procedural characteristics, patients with hypoalbuminemia had higher rates of death (9.94% versus 5.53%, adjusted relative risk [RR]=1.54, p<0.001), pneumonia (5.30% versus 3.77%, adjusted RR=1.20, p=0.012), sepsis (1.19% versus 0.53%, adjusted RR=1.90, p<0.001), and hospital readmission (10.91% versus 9.03%, adjusted RR=1.11, p<0.036; Table 1).

The present study suggests that hypoalbuminemia is a powerful independent risk factor for death following surgery for geriatric hip fracture. This association persists over-and-above any associations of death with age, sex, body mass index, and comorbidities. Based on these data, we propose that the nutritional status of hip fracture patients should receive greater attention, and that randomized trials testing for efficacy of aggressive postoperative nutritional interventions may be warranted.

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The orientation of the acetabular component is influenced by the orientation at which the surgeon implants the component and the orientation of the pelvis at the time of implantation. When operating with the patient in the lateral decubitus position, pelvic orientation can be highly variable. The goal of this study was to examine the effect of two different pelvic supports on cup orientation.

In this prospective study, 200 consecutive patients undergoing uncemented primary THA in the lateral decubitus position were included. In the control group a single support over the pubic symphysis (PS) was used. In the study group, a single support over the ipsilateral anterior superior iliac spine (ASIS) was used. In every patient, the cup was inserted and the angle of the cup introducer relative to the floor (apparent operative inclination; OIa) was measured with the aid of a digital inclinometer. The radiographic inclination (RI) was measured on anteroposterior pelvic radiographs at 6 weeks postoperatively. The target zone for cup inclination was 35–45°.

In both cohorts the cups were implanted close to the target OIa with an absolute difference with the OIa of 0.86° SD 0.82 in the PS cohort and 1.03° SD 0.99 in the ASIS cohort (p=0.18). The difference between the RI and OIa was higher in the PS cohort 12.2° SD 4.1 compared with 7.5° SD 3.7 in the ASIS cohort (p<0.0001) with also a bigger variance (p=0.04) in the PS cohort. The mean RI was 38.5° SD 4.4 compared with 39.2° SD 4.1 (p=0.26) respectively. There were more cups outside the RI target zone in the PS cohort compared with the ASIS cohort (respectively 26 versus 15; p<0.05).

In this study the mean difference between the RI and OIa (the angle of the cup introducer during surgery) was significantly less when using a support over the ASIS compared with a support over the pubic symphysis. Apparently using a support over the ASIS causes less pelvic motion during surgery compared with a support over the pubic symphysis. This resulted in less variance and inclination outliers when using a tight target zone of 35–45°.

The ODEP (Orthopaedic Data Evaluation Panel) rating system should offer a surgeon and patient extra information when making a choice on which implant to use. However, in the current economic environment, ratings may also influence implant choice by contracting bodies. Our aim was to determine the performance of commonly used Acetabular and femoral components in our unit and compare these to their published ODEP ratings (or absence of rating).

We analysed all of the following primary THR components (12,792) for revision for any reason, using same date ranges as ODEP where more than 100 implantations had occurred. Hip components: Trinity (3A in 2013), Trilogy (10A* in 2016), Atlas (10A in 2013), Trilogy TMT (10A 2010) Durom (not rated), BHR (10A, 2010), ACCIS (not rated); Femoral components: Taperfit (10A in 2013), Taperloc (10A* in 2016), Metafix (3A in 2013), CPT (10A in 2012), Ecofit (not Rated), ESOP (not rated), Minihip (3A 2013), Durom (not rated), BHR (10A 2010), ACCIS (not rated).

Analysis of Kaplan Meier survival curves was undertaken for all components. The rated components and non-rated components were compared using HR and logrank tests for all time groups when ratings were introduced. No statistical difference was observed in any group except for the Trinity cup which had a 98.2% (1344 cups) survival at 6 years.

Component survival in our unit was better than ODEP suggested failure for A category of not more than 1% per year, for all components.

Whilst we applaud the intention to improve data available for prostheses, the present ODEP system does not distinguish between performances of different implants in our unit. We therefore recommend care when relying upon ODEP ratings to make clinical or contracting decisions.

Aims

The aims of this study were to describe the prevalence of previous lumbar surgery in patients who undergo total hip arthroplasty (THA) and to investigate their patient-reported outcomes (PROMs) one year post-operatively.

In patients with primary hip replacement for previous infective arthritis the risk of recurrence of infection is of major concern. In addition, the safe time interval post infective arthritis for primary hip replacement is not known.

Clinical & radiological results of consecutive series of 80 primary hip replacements performed for septic / tuberculous arthritis at Wrightington hospital from 1970 to 2008. Data was collected till latest follow up. Re-infection or revision for any reason was considered as primary end point for survivorship.

Average age at primary hip replacement was 55.55 years (24 – 75). Mean follow up was 14.47 years (2–41). Twelve patients in septic hip group (n=42) needed revision out of which 6 (14%) were for infection. The survival rate for recent septic arthritis group (<10 years) was 60% at 7.5 years, whereas in old septic arthritis group (>10 years) it was 94.45% at 15.3 years, considering infection as end point. The survival rate was 60% for recent septic arthritis and 78.13% for old septic arthritis group over the same period of time considering revision for any reason as end point. In tuberculous group (n=38), the survival rate was 76.32% at 14.5 years of follow up, considering revision for any reason as end point.

Significantly high re-infection rate in patients with recent septic arthritis was noted. No recurrence of infection in patients with old septic arthritis. No reactivation of tuberculosis in tuberculous arthritis group.

This is the largest series with longest follow-up on primary total hip replacement for infective arthritis till date. Recent septic arthritis (<10Y) was a statistically high risk factor for recurrence of infection. Old septic arthritis is reasonably safe with 94.45% success rate at 15 years follow up. Old tuberculous arthritis is not a risk factor for hip replacement

To quantify the risk posed to the Lateral Femoral Cutaneous Nerve (LFCN) during Total Hip Arthroplasty using the Minimally Invasive Anterior Approach (MIAA), and during placement of the Anterior Portal (AP) in Supine Hip Arthroscopy (SHA).

Forty-five hemipelves from thirty-nine cadavers were dissected. The LFCN was identified proximal to the inguinal ligament (IL), and its path in the thigh identified. The positions of the nerve and its branches in relation to the MIAA incision and the site for AP placement were measured using Vernier Callipers.

44% of nerves crossed the incision line used in the MIAA, at an average distance of 47 ± 28mm from the proximal end of the incision. Of those that did not cross the incision line, the average minimum distance between the nerve and incision was 14.4 ± 7.4mm, occurring on average 74.0 ± 37.3mm from the proximal end of the incision. In addition, the AP was placed in the path of the nerve on 38% of occasions. The nerve took an oblique path, and when found not to intersect with the AP portal, was located 5.7 ± 4.5mm from the portal's edge. We found a reduction in risk if the portal is moved medially or laterally by 15mm from its current location.

The LFCN is at high risk of injury during both THA using the MIAA and SHA using the AP. Our study emphasises the need for meticulous dissection during these procedures, and thorough explanation of these risk whilst consenting patients. We suggest that relocation of the AP 15mm more laterally or medially will reduce the risk posed to the LFCN.

A modular hemiarthroplasty has a Metal-on-Metal (MoM) taper-trunnion junction, which may lead to increased wear and Adverse-Reaction-to-Metal-Debris (ARMD). To-date no wear related issues have been described in the elderly and less active that receives a hemiarthroplasty. This study aims to determine in vivo wear (i.e. serum metal ion levels) in hip hemiarthroplasty, and identify factors associated with increased wear.

This is a prospective, IRB approved, single-centre, cohort study of patients that received an uncemented, modular hemiarthroplasty of proven design for the treatment of hip fracture between 2013–2015. All, alive, patients at 12-months post-implantation with AMTS≥6 were invited to participate. Of the 125 eligible patients, 50 accepted the invitation and were reviewed, including clinical/radiological assessment, metal-ion ([Chromium (Cr) and Cobalt (Co)]) measurement and Oxford Hip Score (OHS). Acetabular erosion was graded (0–3: normal-protrusio). Metal ion levels were considered high if ≥7ppb.

The mean OHS was 37 (SD: 10). No acetabular erosion was detected in 21, whilst the remaining had either grade-1 (n=21) or grade-2 (n=8). The median Cr and Co levels were 2.9 (SD:9) and 2.2 (SD:4) respectively. There were 8 cases (16%) with high ion levels. To-date only 2 of them has an ARMD lesion, and none have been revised. Patients with metal ion levels had similar pre-fall mobility, taper- and head- size and OHS to those with low metal ion levels (p=0.2–0.7) However, all hips with high metal ion levels had evidence of acetabular erosion (≥1).

Modular Hip hemiarthroplasties and their taper-trunnion junction are not immune to high wear and ARMD despite being implanted in a less active cohort. Acetabular erosion should alert clinicians, as it is associated with 20× increased-risk of taper wear, presumably due to the increased transmitted torque. Whether the use of modular hemiarthroplasties should remain is debatable.

Young Adult Hip [YAH] pathology is now better recognised and treated than decades ago. However, our patients have suggested to us that they encountered delays in recognition and referral.

For the past four years incoming referrals of YAH have been questioned away from the ROH clinic environment in groups of 100 incoming referrals by TS Gambling, Senior Lecturer in Psychology.

Time from onset of symptoms to clinic attendance; number of GP visits; Consultants seen before accurate diagnosis; validity of earlier investigations; severity and effects of symptoms on their daily lives and careers; social effects; body image; self-confidence; oxford hip scores.

The median age was 28 years; the mean delay in being seen at a YAH clinic was 8.3–8.6 years.

The mean number of consultants seen before the YAH clinic was 2.3 – 2.6.

Fewer than 5% were properly investigated by these consultants.

The mean oxford hip score was 30; in only 8% was it less than 20, the common level for hospital referral.

22% were unable to work. In 8% their career was unaffected.

Although 70% were working or pursuing a career, almost all required adaptations /redeployment to sedentary work/Long-term sickness testing employers' tolerance/Intermittent sickness/putting off promotion/ further education/part time working/change of career.

Only 8% were unaffected at work.

In addition, there were profound social effects upon self-esteem, body image, relationships, as well as comfort during sex.

These results do not make comforting news.

In addition to the above difficulties, all our patients expressed; Powerlessness; Frustration; Anger; Not being listened to; being unsupported; Undermined; Humiliation.

The family doctor/ GP services are poor at appreciating the disability in YAH patients.

YAH onset is characteristically at 19.5 years, just when youngsters are becoming independent and self-reliant.

The OHS is an invalid/misleading discriminator in these patients when considering referral.

The hospital orthopaedic service is poor at recognising and investigating YAH disease.

Hip fracture is a common injury with a high associated mortality. Many recommendations regarding timing of operative intervention exist for patients with such injuries. The Best Practice Tariff was introduced in England and Wales in 2010, offering financial incentives for surgery undertaken within 36 hours of admission. The England and Wales National Institute for Health and Clinical Excellence (NICE) Guidance states that surgery should be performed on the day or day after admission. Due to lack of clear evidence, this recommendation is based on Humanitarian grounds. NICE have called for further research into the effect of surgical timing on mortality.

We utilised data from the National Hip Fracture database prospectively collected between 2007 and 2015, comprising 413,063 hip fractures. Using 11 variables, both Cox and Logistic regression analysis was used to establish the effect on mortality of each 12 hour interval from admission to surgery.

For each 12 hour time frame from admission to surgery a trend for improved 30 day survival was demonstrated the earlier the surgery was performed. However, this did not reach significance until beyond 48 hours (Hazard ratio of 1.12, 95% CI: 1.04–1.20). Surgery after 48 hours suffered significantly higher chance of mortality compared to surgery done within 12 hours.

This is the largest analysis undertaken to date. Lowest mortality rates are found within the 0–12 hour window. After 48 hours there is a significant increased risk of mortality compared to the 0–12 hour time frame. As such, expeditious surgery within 48 hours can be justified both on humanitarian and survivorship grounds.

Hip fracture surgery performed within 48 hours is associated with reduced mortality when compared to that beyond this time. This is in agreement with Blue Book recommendations and extends the currently recommended NICE and Best Practice Tariff targets of 36 hours.

With the increasing demand for hip and knee replacement, and the increasing pressure to move towards routine seven-day services within the National Health Service, the trend towards weekend operating is set to increase. We aimed to determine whether planned, elective total hip and total knee replacement performed at the weekend is associated with a different 30-day mortality versus those performed between Monday and Friday.

We used National Joint Registry of England, Wales, Northern Ireland and Isle of Man (NJR) linked to Office for National Statistics (ONS) data. The study dataset comprised 118,096 joint replacement episodes performed at the weekend and 1,233,882 episodes done on a weekday. The main outcome measure was 30-day all-causes mortality. We applied a survivorship analysis using a Kaplan-Meier framework to examine the 30-day cumulative mortality rate for all elective hip and knee replacements performed in England and Wales between 1st April 2003 and 31st December 2014, with Cox proportional-hazards regression models to assess for time-dependent variation and adjust for identified risk factors for mortality.

For hip replacement the cumulative 30-day mortality was 0.15% (95%CI: 0.12–0.19) for patients operated on at the weekend versus 0.20% (0.19–0.21) for patients undergoing surgery during the normal working week. For knee replacement the cumulative 30-day mortality was 0.14% (0.11–0.17) for patients operated on at the weekend versus 0.18% (0.17–0.19) for patients undergoing surgery during the normal working week. The lower mortality associated with weekend operating was most apparent in the later years of the audit (2009 to 2014) and remained after adjustment for any differences in patient age, gender, American Society of Anaesthesiologist grade, surgeon seniority, surgical and anaesthetic practices, and thrombo-prophylaxis choice in weekend versus weekday operated patients.

Hip and knee replacements are routinely performed on Saturdays, and to a lesser extent on Sundays, in England and Wales and are not associated with an increased risk of post-operative mortality.

Although cement in cement acetabular revision is a recognised option in the presence of a well-fixed cement mantle, partial cement mantle retention is not normally recommended or practiced. However, when revising a cemented acetabular cup it is not infrequent to be faced with loose superolateral cement but well-fixed medial cement. Removal of the well-fixed cement can be time consuming and destructive. An alternative would be to retain this cement and incorporate it into the reconstruction. This study assesses the practice and results of partial cement mantle retention (PCR) at acetabular revision.

We retrospectively identified a cohort of 28 hips in 26 patients using the PCR technique from 1^st January 2000 to 1^st January 2013. This represented 3.3% of cup revisions where a cemented cup was used.

The area of cement loss was reconstructed in one of three ways: re-cementing into drill holes (6 cases); impaction grafting of the defect (8 cases); or use of a trabecular metal wedge (14 cases).

24 hips had a minimum 2-year follow up (mean 6 years).

There were no subsequent revisions for aseptic loosening.

One acetabulum was later revised for dislocation and X-rays were lost in one patient leaving 22 patients with x-ray available and retained implants. Two of these cases showed progression of lucent lines, which were not clinically significant.

Retaining well-fixed medial cement during socket revision appears to be a reasonable reconstruction option in carefully selected cases.

Occlusion of the femoral canal is an important step in cemented hip arthroplasty. The goal of occlusion is to allow cement pressurisation and prevent cement egress into the femoral diaphysis. There are numerous designs of cement plugs made out of different materials but there is no consensus or clinical guideline for the choice of cement restrictors. At our centre two types of plugs are used – autologous bone block from femoral canal and the gelatine C-plug (Depuy International). We conducted this study to evaluate the stability of these two plugs and their effect on quality of cementation.

The purpose of our study was to assess retrospectively both the length of the “cement tail” i.e. the length of the cement column distal to the stem tip and the cement mantle quality in both groups.

A retrospective comparative review was designed after approval from the local R & D department. Power analysis indicated that a minimum of 74 patients per group would be needed. A total of 203 consecutive patients were analysed, 89 received an autologous bone block and 114 had C-plugs. Apart from the plugs both the groups were treated similarly with regards to surgical approach, cementing and operative technique. Surgical technique was to achieve adequate pressurisation and a minimum length of cement tail.

Immediate post-operative radiographs were used for analysis. The primary outcome measure was the length of the cement tail, i.e. the length of the cement column from the tip of the stem. The secondary outcome measure was the quality of cementing which was quantified using Barrack's grading.

The data was tested for normality using the Shapiro-Wilk test. The means of cement tail lengths in between the two groups were compared using the Wilcoxon ranked sum test. The cementation grades were compared using ANOVA. The correlation between the length of cement tail and the quality of cementation was calculated using ordinal regression.

Both the groups were similar in terms of age, sex and primary diagnosis. The mean cement tail length was 6.42 (SE 0.71 mms; range-0–31) in the bone block group and 17.11 (SE-1.34 mms; range 0–65.7 mms) in the C-plug group. This difference was statistically significant (p< 0.0001). The proportion of patients with good quality of cementation (grade A) was significantly higher in the bone block group (80.6%) as compared to the C-plug group (56%) (p < 0.0001). There was a negative correlation between the length of the cement tail and the Barrack grade (rho=0.398), indicating that a short cement tail is associated with better quality cementation.

Quality of cementation is of paramount importance in cemented hip arthroplasty. Revision surgery can be more difficult and higher risk in the presence of a long cement tail. We have shown that better quality cementation and shorter cement tails can be achieved with the cheapest of all options for canal occlusion, an autologous bone block and recommend its use.

Infection following total hip or knee arthroplasty is a serious complication. We noted an increase in post-operative infection in cases carried out in a temporary operating theatre. We therefore compared those cases performed in standard and temporary operating theatres and examined the deep periprosthetic infection rates.

A total of 1233 primary hip and knee arthroplasties were performed between August 2012 and June 2013. 44% were performed in temporary theatres. The two groups were matched for age, sex, BMI and ASA grade.

The deep infection rate for standard operating theatres was 0/684 (0%); for temporary theatres it was 8/539 (1.5%); p=0.001.

Use of a temporary operating theatre for primary hip and knee arthroplasty was associated with an unacceptable increase in deep infection. We do not advocate the use of these theatres for primary joint arthroplasty.

In the UK, the posterior approach (PA) and direct lateral approach (DLA) are the most common total hip arthroplasty (THA) procedures. Few studies however, have compared the subsequent functional outcomes. This exploratory study aimed to examine the effect of PA and DLA approaches on post-operative hip kinematics, strength and hip muscle cross-sectional area (CSA), compared to healthy controls.

Participants comprised of 15 cases in the DLA group, > 12 month post-operatively, (ten male, age 68.9+/-5.5 years, BMI 26.9+/-3.0), 13 cases in the PA group (six male; age 72.9+/-6.9 years, BMI 27.1+/-3.6) and 11 age/BMI-matched healthy control participants. All participants underwent 3D kinematic (Vicon, Oxford, UK) and kinetic (AMTI, USA) analysis whist performing self-selected and fast walking as well as sit-to-stand and stand-to-sit. Isometric dynamometry was performed (Biodex Medical systems, USA) for all major muscle groups around the operated hip, and a subset of five participants (three DLA v two PA) underwent “slice encoding for metal artefact correction” (SEMAC) MRI imaging to measure muscle CSA. Patient-reported outcome measures were collected.

Both post-operative surgical groups exhibited altered gait, particularly in limited hip extension, compared to the control participants. The DLA group demonstrated forced hip extension matching controls only under fast walking conditions while the PA group did not achieve hip extension. Both surgical approaches achieved high PROMs scores.

The PA group were weaker for all strength activities tested, whereas the DLA cases demonstrated similar hip strength to controls. SEMAC imaging revealed reduced CSA for those muscles dissected during surgery, compared to the contralateral side.

This exploratory study demonstrated small but measurable differences between surgical approaches for muscle CSA, hip strength of major hip muscle groups and a number of gait variables, although both approaches produce satisfactory functional outcomes for patients after surgery.

Degenerative hip and spine pathologies often co-exist, as Hip-Spine-Syndrome (HSS). Many patients eventually need surgery in both hip (THR) and spine [decompression-spinal-arthrodesis (DSA)]. This case-control study aims to determine whether the presence of a DSA compromised THR outcome and whether outcome of THR is better if performed prior to- (THR-1^st) or after- DSA (THR-2^nd).

This is a single centre, multi-surgeon, retrospective, case-control study. Of the 748 patients that underwent DSA between 2004–15, 43 patients (54 THRs) have also had a 1° THR(s) at our unit and formed the cases. Thirty-two THRs were performed prior to the DSA (THR-1^st) and 22 were done following the DSA (THR-2^nd). Most cases had either 1- (n=3) or 2-level (n=20) DSA. The most common DSA level was L4/5 (n=23). The mean THR-DSA interval was 3.6 years. Controls were patients (n=67) without DSA or previous spinal surgery, that had a THR in our unit over the same study period matched for age, gender and type of THR implanted.

Patient Reported Outcome Measures (PROMs) were obtained using the Oxford-Hip- and Harris-Hip-Scores (OHS/HHS), with the difference between post- and pre-operative scores defined as Δ. Outcome was compared between Cases and Controls and between THR-1^st and THR-2^nd Groups. Outcome measures included complications, revisions, PROMs and cup orientations achieved.

The mean age at THR was 67 years old (SD: 11) and most patients were female (n=82, 68%). The mean cup inclination and anteversion angles were 41° (SD:8) and 21° (SD:8). At a mean follow-up of 6 years, the OHS improved from OHS_pre:16 (SD: 7) to OHS_fu:41 (SD:10) and the HHS improved from HHS_pre:51 (SD:14) to HHS_fu:88 (SD:13).

A greater incidence of complications were seen in the Cases (n=10; ARMD-3, infection-4, loosening-2, dislocation-1) compared to the Controls (n=3; dislocation-2, loosening-1) (p=0.01). Consequently, more THRs required revision in the Cases (n=7) compared to the Controls (n=1) (p=0.01). There were no differences in OHS_pre/OHS_fu/ΔOHS/HHS_pre/HHS_fu/ΔHHS between cases and controls (p=0.1 – 0.9).

There were no difference in complications (7/29 Vs. 3/25; p=0.3), nor revision rates (5/29 Vs. 2/25; p=0.3) between THA-1^st and THA-2^nd Groups. Greater differences in PROMs were detected between the groups. The THA-1^st Group, compared to the THA-2^nd Group had higher OHS_pre (19 Vs 12), HHS_pre (54 Vs 48), OHS_fu (43 Vs 32) and HHS_fu (93 Vs 76), (p=0.001–0.005). However, no statistically significant difference in ΔOHS (24 Vs 17) and ΔHHS (39 Vs 26) were seen between the THA-1^st and THA-2^nd Groups (p=0.1).

Patients with a 1° THR and DSA, had a greater rate complications and revisions compared to a matched control. Overall, no difference in PROMs were seen between Cases and Controls. No significantly increased risk of dislocation was seen in this predominantly 1- and 2-level DSA cohort. The superior PROMs detected in the THA-1^st Group provide evidence that the hip pathology should be addressed 1^st (in cases with 1- or 2-level planned DSA).

When Radiolucent lines (RLL) are observed around cemented acetabular components, they may progress and be associated with loosening.

We reviewed the incidence and progression of RLLs around the Exeter Contemporary flanged acetabular component and compared our results with other published series.

We reviewed a consecutive series of 203 sockets with a minimum 10-year follow-up. Up to date radiographs were reviewed by 2 independent assessors for the presence, location and thickness of RLL and an assessment for loosening/migration was made. Initial post-operative radiographs were examined for any case with RLLs at review.

There were no revisions for aseptic loosening. 103 hips remained in situ with a minimum follow up of 10 years. Lucent lines were seen on 37/103 (36%) of hips with a mean follow up of 12.1 years (10.0–13.9 years). In these 37 hips, the lucency was present in one zone in 84%, two zones in 8% and all three zones in 8%.

Of the 37 hips with a RLL at minimum 10 years follow up, five exhibited a RLL immediately post-operatively. All 5 of these lines were initially isolated to zone 1 and progressed over the 10 years around at least 1 more zone. Only one line became circumferential, although the cup did not migrate.

Compared to previous papers (DeLee & Charnley, Hodgkinson and Garcia-Cimbrelo) the presence of RLL at 10 years is reduced in our series (table 2) and no cup migrated. All RLL seen in cups at both 10 years and immediate post-operatively in our series progressed (table 3), unlike in the previous studies. This reduction in lucent lines may be down to modern cementing techniques, cup design or a combination of both.

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Metallic contacts in hip replacements are susceptible to wear and corrosion processes which lead to the release of particles and metal ions. Adverse local tissue reactions (ALTRs) and systemic manifestations to solid and soluble debris can be debilitating for the patients. It is believed that particles originating from CoCrMo taper junctions trigger more severe body reactions compared to debris from MoM hip bearings. The body's reaction is highly dependent on particle characteristics, such as size, morphology, composition and aggregation state, which can reflect the specific wear and corrosion conditions at the site of release.

Here we proposed to investigate wear and corrosion flakes collected from around CoCrMo tapers at the time of revision. The particles were initially characterised with scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). This revealed the microstructure of the corrosion products, which appeared to be made of smaller metallic aggregates, entrapped in a biological matrix. The in depth characterisation of the particles released from the organo-metallic composite, was performed with transmission electron microscopy (TEM) and scanning transmission electron microscopy (STEM), both fitted with EDX. The investigation revealed clusters and individual nanoparticles, as small as 3 nm, which represent the building blocks of the large corrosion flakes, reported and characterised in the past mainly with low resolution microscopy techniques. The majority of the particles consisted of Cr and O, potentially in the form of chromium oxides, with little evidence of Co and Mo. Particles size distribution (PSD) provided by STEM and TEM characterisation showed statistically different results. The STEM technique was able to resolve tiny particles found in close proximity and provided a PSD shift towards the smaller end of the size range.

The study is the first to show microscopy evidence of Cr rich nanoparticles (3–60 nm) released in vivo from the modular taper interface, which can have important health implications caused by their increased potential to disseminate and corrode within the body.

Bone ingrowth is desired with uncemented hip implants. Infection is clearly undesirable. We have worked on developing a nanofiber coating for implants that would enhance bone formation while inhibiting infection. Few studies have focused on developing an implant surface nanofiber (NF) coating to prevent infection and enhance osseointegration by local drug release. In this study, coaxial doxycycline (Doxy)-doped polycaprolactone/polyvinyl alcohol (PCL/PVA) Nanofibers were directly deposited on the titanium (Ti) implant surface during electrospinning.

The interaction of loaded Doxy with both PVA and PCL NFs was characterized by Raman spectroscopy. The bonding strength of Doxy-doped NF coating on Ti implants was confirmed by a stand single-pass scratch test. The improved implant osseointegration by PCL/PVA NF coatings in vivo was confirmed by scanning electron microscopy, histomorphometry and micro computed tomography at 2, 4 and 8 weeks after implantation. The bone contact surface (%) changes of NF coating group (80%) is significantly higher than that of no NF group (< 5%, p<0.05). Finally, we demonstrated that Doxy-doped NF coating effectively inhibited bacterial infection and enhanced osseointegration in an infected (Staphylococcus aureus) tibia implantation rat model. Doxy released from NF coating inhibited bacterial growth up to 8 weeks in vivo. The maximal push-in force of Doxy-NF coating (38 N) is much higher than that of NF coating group (6.5 N) 8 weeks after implantation (p<0.05), which was further confirmed by quantitative histological analysis and micro computed tomography.

These findings indicate that coaxial PCL/PVA NF coating doped with Doxy and/or other drugs have great potential in enhancing implant osseointegration and preventing infection.

When inserting a femoral stem, surgeons make use of many visual and tactile cues to be sure that the implant is correctly sized and well-seated. One such cue is the change of pitch that can be heard when the final femoral broach is inserted. This is known to be important, but has not been widely studied.

We set out to analyse the sounds produced during femoral broaching and implant fixation, and to discover whether the absence of these sounds could predict a poor fixation.

We recorded the sound of femoral broaching and definitive implant insertion, for twenty un-cemented Corail total hip replacements. Procedures were performed by the same surgeon, in the same theatre. The recordings were visualised using audio editing software, and a Fast Fourier Transform was used to identify the dominant audio frequencies.

In 19 of the 20 cases, the final strikes of the final femoral broach displayed a distinctive pattern, with the most prominent frequencies being harmonics (multiples of a fundamental frequency) which had a wavelength directly related to the length of the femoral canal. This contrasts with initial strikes, where multiple unrelated frequencies were present.

Postoperative radiographs were examined by two surgeons independently, to assess implant sizing and positioning. The one case, in which the harmonic pattern was not observed, was found on radiographs to be an undersized, varus malpositioned implant.

We demonstrate that a characteristic frequency pattern is present when impacting cancellous bone with a well-sized and well-placed femoral broach. When the pattern was absent, the broach and implant were undersized and malpositioned. We hypothesise that this pattern arises when broach and femur are vibrating as one, indicating adequate contact with, and compression of, cancellous bone.

Deep infection occurs in 2–4% of lower limb arthroplasty resulting in increasing cost, co-morbidity and challenging revision arthroplasty surgery. Identifying the potential sources of infection helps reduce infection rates. The aim of our study is to identify the impact and potential for contamination of our hands and gowns whilst scrubbing using SSHS.

A colony-forming unit (CFU) is a pathogenic particle of 0.5 micrometers to 5 micrometers. Concurrent particle counts and blood agar exposure settle plates for 3 subjects and 1 alcohol cleaned mannequin; testing a standard arthroplasty hood, a SSHS with and without the fan on for a 2 minute exposure to represent scrubbing time. Microbiological plates were incubated using a standard protocol by our local microbiology department.

All SSHS were positive for gram-positive cocci with a mean colony count of 410cfu/m². Comparing background counts for laminar flow (mean 0.7 particle/m³; 95% CI 0–1.4) versus scrub areas (mean 131.5 particle/m3; 95% CI 123.5–137.9; p=0.0003), however neither grew any CFU's with a 2-minute exposure. For the mannequin, the only significant result was with the fan on with a 1.5× increase in the particle count (p=0.042) and a correlating positive organism (13CFU/m²). With human subjects, however, the particle count increased by 3.75× the background count with the fan on (total p=0.004, CFU p=0.047) and all had positive cultures, mean 36 CFU/m². There were no positive cultures with the standard arthroplasty hood or the SSHS with no fan on. If repeated in laminar flow, there was only a statistically significant increase with the fan on (p=0.049), but with negative cultures following a 2-minute exposure.

Sterile gloves and gowns can be contaminated when scrubbing with the SSHS fan on. We recommend having the fan switched off when scrubbing until the hood and gown is in place, ideally in a laminar flow environment.

Total hip arthroplasties are known to corrode predominantly at the taper junctions between Cobalt Chromium Molybedenum (CoCrMo) and Titanium (Ti) alloy components.

We aimed to understand the modes underlying clinically significant tissue reactions to metals from corroded implants by determining: (1) what type of metal is present in the tissues, (2) which cells contain the metal species and (3) how this compares with results from metal-on-metal (MOM) hip resurfacings (HRs).

This study involved periprosthetic tissue from patients that had undergone revision surgery due to adverse reactions to metal debris (ARMD) from dual-taper prostheses consisting of Ti-based alloy stems paired with CoCrMo necks. We used Synchrotron micro X-ray Fluorescence Spectroscopy (µXRF) and micro X-ray Absorption Near Edge Spectroscopy (µXANES) for detection of Co, Cr and Ti, and determination of their oxidation state.

Synchrotron radiation has shown that the chromium in tissues is Cr₂O₃ when derived from corroded CoCrMo/Ti junctions beside the CrPO₄ species found when hip implants release CoCrMo nanoparticles from their bearing surfaces (MoM HRs). Presence of Cr₂O₃ was associated with titanium oxide TiO₂. This may be the outcome of the chemical interaction between the two species. Histological examination showed corrosion products present within viable macrophages and in the extracellular connective tissue, Figure 1.

Understanding corrosion at taper junctions and the pathogenesis of the biological response is of significant clinical importance. This is the first study to co-register histology and metal distribution maps and to explore the potential synergy effect of CoCrMo with Ti alloy.

This study provides guidance for toxicological studies on wear/corrosion particles, how they stimulate the host response and the cellular mechanisms involved in the pathogenesis of ARMD.

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We have developed a technique with the underlying principle being that the difference in height between what is removed and what is inserted will determine the leg length correction (Figure 1). The height of the implant to be inserted is determined from the manufacturer's specifications. We have developed a Vertical Measurement Tool to accurately and reproducibly determine the height of the resected bone (Figure 2).

Leg length correction = a−b−c+d

Vertical Measurement Tool validation was performed by 4 separate surgeons on 20 resected femoral heads in the laboratory. Inter and intra-observer error was assessed. Fifty patients were assessed clinically and radiologically, to assess if desired leg length correction was achieved.

Statistical analysis showed the device to be accurate with high intra and inter observer reliability. Differences between the observers were tested using a general linear model in a repeated measure design. No main effect and interaction effects were found. Intra operatively the resected head was measured and the formula was applied. The range of desired correction was 0mm to 18mm. In all cases the post-operative correction was within 4mm of the pre-operative planned correction. Statistical analysis showed that a linear Regression with ‘Actual’ as dependent and ‘Lambda’ as independent variables resulted in R= 0.889.

We believe that it is consistently possible to achieve a leg length correction to within 5 mm of the pre-operative plan using the Vertical Measurement System. The system is simple and reproducible even in the hands of relatively inexperienced surgeons.

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Patients with a painful or failed total joint arthroplasties should be evaluated for periprosthetic joint infection (PJI). The purpose of this study was to determine if patients referred to a tertiary care centre had been evaluated for PJI according to the American Academy of Orthopaedic Surgeons (AAOS) clinical practice guidelines.

113 Patients with painful hip (43) or knee (70) arthroplasties were referred to a single provider by orthopaedic surgeons outside our practice between 2012 and 2014. We retrospectively evaluated the workup by referring physicians, including measurement of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), performance of a joint aspiration if these values were abnormal, and obtainment of synovial fluid white blood cell (WBC) count, differential, and cultures.

Sixty-two of the 113 patients (55%) did not have a workup that followed AAOS guidelines. Serum ESR and CRP were ordered for 64 of the 113 patients (57%). Of 25 patients with elevated inflammatory markers warranting aspiration, 15 (60%) had an aspiration attempted, with synovial fluid WBC, differential, and cultures obtained in 9 of 12 (75%) aspirations that yielded fluid. Of the 62 patients with an incomplete infection workup, 11 (18%) had a bone scan, 6 (10%) a CT scan, and 3 (5%) an MRI. Twelve of the 113 patients (11%) were ultimately diagnosed with PJI, with 5 undiagnosed prior to referral.

The AAOS guidelines to evaluate for PJI are frequently not being followed. Improving awareness of these guidelines may avoid unnecessary and costly evaluations and delay in the diagnosis of PJI.

Synovasure has been designed and validated for use in the diagnosis of periprosthetic joint infection (PJI). It has a reported sensitivity of 97.4% (CI 86.1–99.6%) and specificity of 95.8% (CI 90.5–98.6%), higher than the variable results reported for aspiration by most units. At a cost of £500 per test, we aimed to establish cost-effectiveness and diagnostic accuracy, to determine its role in routine practice.

We developed a protocol for pre-operative aspiration or intra-operative use. Prerequisites for entry were a high index of clinical suspicion for PJI and equivocal standard investigations. All cases were discussed at the lower limb arthroplasty MDT and approved only if use would change clinical management.

Over 15 months, 36 tests were approved for 22 aspirations (5 hip, 17 knee) and 14 intra-operative cases (7 hip, 7 knee). 10/36 had undergone previous revision surgery. 35/36 cases complied with the protocol. All 22 Synovasure aspirations were negative, corresponding to the microbiology in all but one case; thought to be a contaminant. In the intra-operative group there was one true positive and 12 true negative tests, giving a sensitivity of 100% (95% CI 2.5–100%) and a specificity of 100% (95% CI 73.5–100%). Synovasure influenced decision making in 34/36 procedures. One test failed and in another there was evidence of frank infection. In 11 cases no surgery was performed versus a potential two-stage revision and in 21 cases a single rather than two-stage revision was performed. Resulting in estimated savings of £686,690, offset against a cost of £18,000.

The Synovasure test was found to be sensitive and specific and can aid decision-making particularly in complex cases with an equivocal diagnosis of PJI. The use of this test through a robust protocol driven peer review MDT process not only reduces patient morbidity but drives significant efficiency savings.

Infection after total hip arthroplasty (THA) is a devastating complication. With an ageing population and increased demands for THA, prosthetic joint infection (PJI) is expected to become an even greater problem in the future. In late PJI a one- or two-stage revision procedure is most often used. Factors determining the outcomes are not fully understood and there is controversy in the choice between the two methods. The, two-stage method in infected THA is regarded as more resource demanding and is associated with a high distress in the patients.

The aim of this study was to compare the risk for second revision (re-revision) between one- and two-stage revision.

During 1979–2015, 1659 first-time revisions performed due to infection were reported to the Swedish Hip Arthroplasty Register. Two-stage revision was the most common procedure (n=1255). Risk for a re-revision was compared between one- and two-stage revision using Cox-regression analysis adjusted for age, sex, diagnosis and method of fixation. The primary end-point was a re-revision regardless of cause. Aseptic loosening, infection, and dislocation necessitating re-revision were used as secondary outcomes.

There was no difference in risk of re-revision regardless of cause (HR (one-stage/two-stage)=0.9, 95% C.I.=0.7–1.1, p=0.3), re-revision due to aseptic loosening (HR=1.1, 95% C.I.=0.7–1.6, p=0.7) or re-revision due to infection (HR=0.7, 95% C.I.=0.5–1.1, p=0.2). Dislocation necessitating a re-revision was less common in the one-stage group (HR=0.4, 95% C.I.=0.2–0.9, p=0.03).

In this analysis re-revision rates were similar in the two groups. When analysed specifically for infection, risk of re-revision did not differ between one and two stage revision. Our findings confirm recent systematic reviews on the matter.

This observational study supports increased utilisation of the one-stage approach. However prospective randomized studies are needed to validate these findings.

Clinical graphics allows creation of three dimensional simulation based on CT or MRI that allows pre-operative planning. The software reports several hip morphological parameters routinely. Our aim was to validate the measurements of acetabular morphological parameters using CT based clinical graphics in patients presenting with symptomatic hip pain.

We reviewed standardised plain radiographs, CT scans and 3D clinical graphics outputs of 42 consecutive hips in 40 patients presenting with symptomatic hip pain. Acetabular index (AI), lateral centre edge angle (LCE), acetabular and femoral version measurements were analysed for the 3D clinical graphics with radiographs and CT as gold standard.

Significant differences were noted in measurements of AI, LCE, acetabular version and femoral version using the 3D motion analysis versus conventional measures, with only acetabular version showing comparable measurements. Correlation between 3D clinical graphics and conventional measures of acetabular morphology (AI, LCE) showed only slight agreement (ICC <0.4); while substantial agreement was noted for acetabular and femoral version (IC > 0.5).

Acetabular morphological parameters measured by 3D clinical graphics are not reliable or validated. While clinicians may pursue the use of 3D clinical graphics for preoperative non-invasive planning, caution should be exercised when interpreting the reports of hip morphological parameters such as AI and LCE.

Arthroscopic procedures are increasingly performed for femoroacetabular impingement (FAI). The Non-Arthroplasty Hip Register (NAHR) collects data including the iHOT12 and EQ5D. However there is currently little evidence of its usefulness in assessing hip arthroscopy outcomes. This study aims to assess minimum 1-year outcomes of hip arthroscopy for FAI using the minimum data set (MDS) of the NAHR by comparing these to a patient satisfaction questionnaire.

Pre-operative scores for 78 consecutive hips in 76 patients (43F/33M, mean age at surgery 31.76±10.02 years) undergoing hip arthroscopy for FAI at our institution between February 2013-June 2015 were entered into the NAHR. Insufficient post-operative data was available from the registry. Therefore we collected iHOT12, EQ5D and satisfaction data by postal survey.

Preoperative mean iHOT-12 score was 32.67±14.23, median EQ5D Index score 0.653 (IQR 0.277) and median EQ5D Visual Analogue Scale 70 (IQR 25). Postoperative scores were available for 56 cases (55 patients, 71.8%) at median 18.9 months (IQR 13.77). There was a significant postoperative improvement in self-reported outcome as measured by iHOT-12 (mean improvement 35.7 points, p<0.001) and EQ5DIndex scores (median improvement 0.127, p=0.001). 24 patients were very satisfied, 19 satisfied, 6 neutral, 4 dissatisfied and 1 very dissatisfied. Satisfied patients exhibited greater improvement in iHOT-12 (mean 41.64±19.29 vs 2.8±24.08, p<0.001) and EQ5D index scores (p=0.013) but no difference in EQ5D VAS (p=0.15). Improvement in iHOT12 correlated with improvement in EQ5DIndex (r=0.676, p<0.001) and EQ5DVAS(r=0.552, p<0.001).

Hip arthroscopy for FAI yielded significant improvements in iHOT-12 and EQ5D index scores and 80% of responders were satisfied/very satisfied at a minimum one year postop. iHOT12 and EQ5DIndex correlated with patient satisfaction and improvements in iHOT12 correlated with improvements in general quality of life. Our findings suggest that the MDS of the NAHR is useful for assessing the outcome in these patients.

Recently, corrosion at the head-neck junction in metal-on-polyethylene bearing total hip arthroplasty (THA) has been recognized as a cause of adverse local tissue reactions (ALTR). Serum metal levels have been advocated as a tool for the diagnosis of ALTR, however no prior studies have specifically examined their utility. The purpose of this study was to determine the optimal cut-off values for serum cobalt and chromium in diagnosing ALTR after metal-on-polyethylene bearing THA.

We reviewed 447 consecutive patients with serum metal levels tested at our institution and identified 62 with a metal-on-polyethylene bearing who had axial imaging or underwent reoperation to confirm the presence or absence of ALTR. Receiver operating characteristic curves were produced to identify cut-off thresholds to optimize sensitivity and diagnostic test performance was characterized.

42 Of the 62 patients (66%) were positive for an ALTR. The best test for the diagnosis of ALTR was the serum cobalt level (area under the curve [AUC]=99%). A threshold cut-off of ≥ 1.0 ng/ml had a sensitivity of 100%, specificity of 90%, positive predictive value (PPV) of 96%, and negative predictive value (NPV) of 100%. Serum chromium levels were also diagnostic (AUC=87%). A threshold cut-off of ≥ 0.15 ng/ml had a sensitivity of 100%, specificity of 50%, PPV of 81%, and NPV of 100%. Finally, serum cobalt to chromium ratio was also helpful for diagnosis (AUC=90%). A threshold cut-off of 1.4 for the cobalt to chromium ratio offered a sensitivity of 93%, specificity of 70%, PPV of 87%, and NPV of 82%.

Measurement of serum cobalt with a threshold value of 1.0 ng/ml in our experience is the best test for identifying the presence of ALTR in patients with a metal-on-polyethylene THA. Measurement of chromium and the ratio of cobalt to chromium are also of value.

During the last decade primary total hip arthroplasty surgery (THA) has increased with 30% in Sweden. Current law guarantees the patient a right to treatment within 90 days. The public health system has had difficulties meeting the increasing demand. Therefore, in 2012 a systematic review of the patients planned for THA was initiated at Sahlgrenska University Hospital's joint replacement unit. In late 2013 the value-based health care (VBHC) management was introduced in our unit.

In 2012 a systematic approach based on the Fast-Track concept was implemented in the joint replacement unit. In 2013 a workgroup consisting of health care professionals involved in the treatment of THA patients was created to improve chosen outcome parameters.

During 2011–2016 the number of elective THA has increased from 317 to 486. The cost per patient has decreased from 75,000 SEK to 65,000 SEK. Length of stay has decreased from 5.9 days to 2.5 days. Satisfaction with outcome of surgery one year after THA increased from 76% to 88%. The number of adverse events decreased from 29% to 11%. Number of re-operations within 2 years decreased from 2,7% to 1,9%.

Fast-Track and VBHC management was initially received with modest enthusiasm in our unit, and was regarded as means to increase production whilst possibly endanger the well-being of the patients. By using continuous feedback using the data collected it was possible to effectively communicate to patients and caregivers that the patients benefitted from the implementation.

VBHC primary aim is to improve patient outcomes and synergetically improve cost and process measurements. This should be appealing to both caregivers and administrators.

Focusing on improvement of outcomes after THA combined with VBHC management has contributed to improvement in quality of care and availability of treatment whilst decreasing cost per patient.

Aims

Femoral stems with exchangeable (modular) necks were introduced to offer surgeons an increased choice when determining the version, offset and length of the femoral neck during total hip arthroplasty (THA). It was hoped that this would improve outcomes and reduce complications, particularly dislocation. In 2010, the Australian Orthopaedic Association National Joint Replacement Registry (AOANJRR) first reported an increased rate of revision after primary THA using femoral stems with an exchangeable neck. The aim of this study was to provide a more comprehensive up-to-date analysis of primary THA using femoral stems with exchangeable and fixed necks.

Aims

The most effective surgical approach for total hip arthroplasty (THA) remains controversial. The direct anterior approach may be associated with a reduced risk of dislocation, faster recovery, reduced pain and fewer surgical complications. This systematic review aims to evaluate the current evidence for the use of this approach in THA.

Aims

It may not be possible to undertake revision total hip arthroplasty (THA) in the presence of massive loss of acetabular bone stock using standard cementless hemispherical acetabular components and metal augments, as satisfactory stability cannot always be achieved. We aimed to study the outcome using a reconstruction cage and a porous metal augment in these patients.

Aims

The stability of cementless acetabular components is an important factor for surgical planning in the treatment of patients with pelvic osteolysis after total hip arthroplasty (THA). However, the methods for determining the stability of the acetabular component from pre-operative radiographs remain controversial. Our aim was to develop a scoring system to help in the assessment of the stability of the acetabular component under these circumstances.

Aims

To determine ten-year failure rates following 36 mm metal-on-metal (MoM) Pinnacle total hip arthroplasty (THA), and identify predictors of failure.

Aims

Lumbar fusion is known to reduce the variation in pelvic tilt between standing and sitting. A flexible lumbo-pelvic unit increases the stability of total hip arthroplasty (THA) when seated by increasing anterior clearance and acetabular anteversion, thereby preventing impingement of the prosthesis. Lumbar fusion may eliminate this protective pelvic movement. The effect of lumbar fusion on the stability of total hip arthroplasty has not previously been investigated.

Aims

Advocates of debridement, antibiotics and implant retention (DAIR) in hip periprosthetic joint infection (PJI) argue that a procedure not disturbing a sound prosthesis-bone interface is likely to lead to better survival and functional outcome compared with revision. This case-control study aims were to compare outcome of DAIRs for infected primary total hip arthroplasty (THA) with outcomes following primary THA and two-stage revision of infected primary THAs.

Objectives

Favourable results for collarless polished tapered stems have been reported, and cement creep due to taper slip may be a contributing factor. However, the ideal cement thickness around polished stems remains unknown. We investigated the influence of cement thickness on stem subsidence and cement creep.

Objectives

The use of ceramic femoral heads in total hip arthroplasty (THA) has increased due to their proven low bearing wear characteristics. Ceramic femoral heads are also thought to reduce wear and corrosion at the head-stem junction with titanium (Ti) stems when compared with metal heads. We sought to evaluate taper damage of ceramic compared with metal heads when paired with cobalt chromium (CoCr) alloy stems in a single stem design.

Objectives

Fractures of the proximal femur are a common clinical problem, and a number of orthopaedic devices are available for the treatment of such fractures. The objective of this study was to assess the rotational stability, a common failure predictor, of three different rotational control design philosophies: a screw, a helical blade and a deployable crucifix.

Aims

The objective of this five-year prospective, blinded, randomised controlled trial (RCT) was to compare femoral head penetration into a vitamin E diffused highly cross-linked polyethylene (HXLPE) liner with penetration into a medium cross-linked polyethylene control liner using radiostereometric analysis.

Aims

Modular or custom-made femoral components have been preferred for total hip arthroplasty (THA) in patients with a history of Perthes’ disease because of the distortion in the anatomy of the proximal femur. However, it has not been established whether a monobloc cementless stem will fit the distorted proximal femur or whether the results of the procedure are satisfactory in this group of patients.

Aims

This study aimed to determine the diagnostic performance of radiographic criteria to detect aseptic acetabular loosening after revision total hip arthroplasty (THA). Secondary aims were to determine the predictive values of different thresholds of migration and to determine the predictive values of radiolucency criteria.

Aims

Recently, there has been considerable interest in quantifying the associations between bony abnormalities around and in the hip joint and osteoarthritis (OA). Our aim was to investigate the relationships between acetabular undercoverage, acetabular overcoverage, and femoroacetabular impingement (FAI) with OA of the hip, which currently remain controversial.