Introduction:. Appropriate transverse rotation of the tibial component is critical to achieving a balance of tibial coverage and proper tibio-femoral kinematics in total knee replacement (TKR), yet no consensus exists on the best anatomic references to determine rotation. Historically, surgeons have aligned the tibial component to the medial third of the tibial tubercle. 1. , but recent literature suggests this may externally rotate the tibial component relative to the femoral epicondylar axis (ECA) and that the medial border of the tubercle is more reliable. 2. Meanwhile, some TKR components are designed with asymmetry of the tibial tray assuming that maximizing component coverage of the resected tibia will result in proper alignment. The purpose of this study was to determine how different rotational landmarks and natural variation in osteoarthritic patient anatomy may affect asymmetry of the resected tibial plateau. Methods:. Pre-operative computed-tomography scans were collected from 14,791 TKR patients. The tibia and femur were segmented and anatomic landmarks identified: tibial mechanical axis, medial third and medial border of the tibial tubercle, PCL attachment site, and the surgical ECA of the femur. Virtual surgery was performed with an 8-mm resection (referencing the high side) made perpendicular to the tibial mechanical axis in the frontal plane, with 3° posterior slope, and transversely aligned with three different landmarks: the ECA, the medial border, and medial third of the tubercle. In each of these rotational alignments, the relative asymmetry of the medial and lateral plateaus was calculated (Medial AP/Lateral AP) (Fig. 1). Results:. Rotational alignment of the tibial component to the ECA, medial border, and medial third of the tubercle resulted in progressive external rotation of the tibial tray on the bone. Alignment to the medial border and medial third of the tubercle resulted in average 0.9° ± 5.7° and 7.8° ± 5.3° external rotations of the tray relative to the ECA, respectively (Fig. 2). Greater external rotation of the tibial implant relative to the bone increased the appearance of tibial asymmetry (Fig. 3). Referencing the medial border and medial third of the tubercle resulted in apparent tibial bone asymmetry of 1.10 ± 0.10 and 1.12 ± 0.10, respectively. Discussion:. Assuming the ECA is the appropriate rotational reference to re-establish appropriate kinematics. 2. , alignment to the medial border of the tubercle resulted in the most favorable tray alignment. However, there was a great deal of variation between the relative position of the ECA and the tubercle across the patient population. Rotational alignment to either the medial border or medial third of the tubercle resulted in external tray alignment relative to the ECA of greater than 3 degrees for 36% and 84% of patients, respectively. In addition, increased tray asymmetry (broader medial plateau) necessitates relative external rotation of the tray on the bone reducing the flexibility of intra-operative rotational adjustment. Tray asymmetry greater than 1.10 (the asymmetry of the resected tibia when aligned to the ECA) may result in external mal-rotation for a significant portion of the patient population

The “correct” rotational alignment and “normal” rotational alignment may not be the same position. Because of natural tibial plateau has average 3° varus but classical TKA method make tibial cut perpendicularly to tibial mechanical axis. Consequently femoral rotational compensation to 3° becomes necessary. While anatomical TKA method performed tibial cut in 3° varus. Then posterior femoral cut will be parallel to posterior condylar axis and component rotation theoretically should be aligned in natural anatomy. This study compares the rotational alignment between two methods. Study conducted on 80 navigated TKAs with modified gap technique. Intraoperative femoral rotation retrieved from navigation. Rotational alignment was calculated using the Berger protocol with postoperative computerised tomography scanning. The alignment parameters measured were tibial and femoral component rotations and the combined component rotations. 57 knees with PS design can be classified into 35 knees as anatomical group and 22 knees as classical group. 23 knees with CR design had 12 knees as anatomical group and 11 knees as classical group. The intraoperative femoral rotation in anatomical group had less external rotation than classical group significantly in PS design (0.77°±1.03° vs 2.86°±1.49°, p = 0.00) and also had the same results in CR design (1.33°±1.37°vs 2.64°±0.81°, p = 0.012). However, the postoperative excessive femoral and tibial component rotation compared with native value and combined rotation had no significant differences between classical and anatomical method in both implant design. Using CAS TKA with gap technique showed no difference in postoperative rotational alignment between classical and anatomical method

Introduction. Current pre-clinical testing is performed using knee wear simulators with standardized walking profiles. Differences in generated damage patterns to those observed on retrieved liners have been explained with the absence of activities other than walking, less severe loading conditions, and a discrepancy in the simulator's tibiofemoral contact mechanics and in vivo knee excursion. While it has been recognized that rotational alignment of the knee may also drive the location and shape of wear scars, to the best of our knowledge this parameter has not been investigated in knee simulator studies. Methods. Here, we use patient specific gait as input to the simulation to approximate the patient specific contact mechanics. Kinematic and kinetic input data was obtained from gait analysis of a patient with a MGII (Zimmer Inc.) prosthesis at 11 years post-op using the point cluster technique for tibiofemoral kinematics, and a mathematical model for internal force calculations. Using the identical type of prosthesis on the simulator, wear tests were conducted in displacement mode on a closed-loop controlled station. Because x-rays of the patient suggested an internal rotation of the tibial tray, it was varied form 0–10° and the effect on location and wear scar dimension was assessed. Results were compared with the retrieved liner (obtained after 13 years in vivo). Results. The simulator inputs generated from the gait data were compared with ISO 14243–3 (Figure 1). The first contact force peak of the patient was significantly lower, while second contact force peak similar to ISO. There were minimal differences in the flexion/extension profiles. For stance phase, the anterior/posterior translation and internal/external rotation kinematics did not show similar patterns, but they did fall within similar ranges from zero. There was little similarity for the swing phase. The total wear scar area of the retrieval was measured to be 919.8 mm. 2. The average total wear scar of the tested components was 853.0 ± 59.8 mm. 2. (p= 26.28%) The outcome values of the tested components compared to the retrieval are shown in Figure 2. All offsets produced a smaller wear scar than the retrieval, but the 7° offset produced the closest area which was within 1 mm. 2. of the retrieval. The 7° offset also had the closed centroid offset angle, which was within 0.2° of the retrieval (Figure 3). On the retrieval, a small wear scar was observed on the anterior- medial aspect of the intracondylar eminence (not shown). Among the tested components, the 7° and 10° offsets recreated damage at this location. Discussion. Rotational alignment affected the wear scar size by as much as 15% in this study. Only, the 7° offset produced outcome values very similar to the retrieval, highlighting the importance of rotational mismatch for wear. It should be noted that ± 10° of rotational mismatch is clinically well tolerated [5] and therefore may occur frequently. All tested components had smaller wear scar areas than the retrieved liner. This suggests that other activities other than walking may have contributed to wear in vivo

Aims: Does CT-less navigation using the NAVITRACK-System improve post-operative rotational alignment of prosthesis compared to not-navigated implantation technique?. Methods: A total number of 250 patients was enrolled into a randomized mono-centre-study. Ninety patients received computer-aided-surgery (CAS), 160 patients received not-navigated implantation technique. Mechanical leg-/femur-/tibia-axes were identified using complete-leg-CT-scans. Rotational alignment was calculated measuring the angles formed between condylary and epicondylary axes (femoral), transverse tibia plateau axis and tibial tuberosity (tibial) respectively, by the use of coronar CT-scans. Knee Society – and SF-36-Scores were collected pre- and post-operatively at 6 weeks /6 months. Statistical analysis was performed by the chi-square-test. Results: (All values in mean +− SEM (range)) A mechanical-axis-range of 180 +− 3 was achieved in 97,9% of navigated, and in 76,8% of the not-navigated patients. The tibial component was placed in a 2,1 +− 1,3 -varus-position in navigated patients. In the conventional patient group varus position was 1,8 +− 1,4. A 0,8 +− 1,5 femoral-valgus-position was found in navigated patients, respectively a 0,3 +− 2,7 varus-position in the not-navigated. The internal rotation (relative to epicondylar axis) of the femoral component was 2.8 +− 1,0 (0,7–3,8) in the CAS-group and 2.1 +− 1,5 (0–5,9) in the non-navigated. On the tibial side, the internal rotation of the plateau relative to tibial tuberosity was 20.5 +− 2.5 (16,8–24,8) in CAS- and 22.2 +− 7.5 (9,3–43,2) in the conventionally treated patients. Conclusions: CT-less navigation using NAVITRACK was suitable to a.) reconstruct mechanical axis within the limits of 180° +− 3° and b.) reduce rotational malalign-ment especially on the tibia. The system may improve the survivorship of TKR as well as the functional outcome after implantation

Accepted landmarks for determining rotation include the posterior condyles, Whiteside’s line, arbitrary 3-4° of external rotation, and transepicondylar axis (TEA). All methods require anatomical identification, which may be variable. The purpose of this study was to radiologically evaluate femoral component rotation (CT analysis) based on a method that references to the tibial axis and balanced flexion-tension. Methods: CT scans of 38 randomly selected TKA were evaluated to determine femoral component positioning. Spiral CT scans of the femoral epicondylar region with eight 4mm cuts were performed to accurately identify medial and lateral epicondyles. Rotational alignment was measured in relation to the transepicondylar axis using CT-implemented software by two independent radiologists. Results: Femoral component rotation ranged from 4° internal rotation to 5° external rotation with a mean of 0.0° = parallel to the TEA. All 38 cases had satisfactory clinical results, range of motion of over 90°, and showed perfect patello-femoral tracking and patellar congruency. Conclusions: Femoral rotation position based on tibial axis and balanced flexion tension is patient specific, reproducible and results in predictable patella tracking. CT analysis in this study confirms that the tibial axis method produces a consistent femoral component positioning that relates accurately to the TEA. Tibial axis method avoids the need for arbitrary landmark identification, placing the femoral component predictably in an optimum position in relation to the tibia and patella

Introduction

Rotational or axial alignment is an important concept in total knee surgery. Malrotation of the femoral component can lead to patellofemoral maltracking, pain and stiffness. In reconstruction surgery of the knee, achievement of correct rotation is even more difficult because of the lack of anatomical landmarks. The linea aspera is often the only remaining landmark, but its reliability is questionable.

We proposed the substitute anteroposterior (sAP) line of the tibia for medial unicompartmental knee arthroplasty (UKA), which connects the medial border of the patellar tendon at the articular surface level and the medial intercondylar tubercle of the tibia. However, it has not been shown that referencing this line improves the rotational alignment of the components. Therefore, in this study, we investigated whether the tibial component could be implanted perpendicular to the SEA by referencing the sAP line and whether referencing the sAP line could reduce the rotational mismatch between the femoral and the tibial components.

Postoperative computed tomography datasets from 60 lower limbs in 57 Japanese patients with medial UKA were used. Among these, 30 knees were operated using the sAP line for AP reference and other 30 knees using the medial intercondylar ridge (MIR) line. First, the angle between the AP orientation of the tibial component and the surgical epicondylar axis (SEA) was measured. Then, the rotational mismatch angle between the components was measured.

The tibial and femoral components placed referencing the sAP line were externally rotated 90.7°±3.2° and 91°±7.7° relative to the SEA, respectively, those referencing the MIR line were 94.9°±8.5° and 91.2°±7.7°, respectively. When referencing the sAP line, the orientation of the component was more perpendicular to the SEA (Student t-test, unpaired, P = .016) and rotational variability of the tibial component was significantly smaller (F test, P < 0 .0001). The rotational mismatch angle when referencing the sAP line and the MIR line was 0.3°±8.3°and −3.8°±6.7°, respectively. Referencing the sAP line significantly reduced the rotational mismatch between the components (Student t-test, unpaired, P = .045).

Referencing the sAP line in the medial UKA may be useful to determine the AP orientation of the tibial component.

Introduction and Objective

The geometry of the proximal tibia and distal femur is intimately linked with the biomechanics of the knee and it is to be considered in total knee arthroplasty (TKA) component positioning. The aim of the present study was to evaluate the proximal tibial torsion in relation to the flexion-extension axis of the knee in healthy and pathological cohort affected by knee osteoarthritis (OA).

Three distal femoral axes have been described to aid in alignment of the femoral component; the Trans Epicondylar Axis (TEA), the Posterior Condylar Axis (PCA) and the Antero Posterior (AP) axis. Our aim was to identify if there was a reproducible relationship between the axes which would aid alignment of the femoral component. This is the first study compare all three distal femoral axes with each other using magnetic resonance imaging (MRI) in a Caucasian population. Our sample group represents real life patients awaiting total knee arthroplasty (TKA), as opposed non-arthritic or cadaveric knees.

We identified the relationship between these rotational axes by performing MRI scans on 89 patients awaiting TKA with patient-specific instrumentation. Measurements were taken by two observers.

Patients had a mean age of 62.5 years (range 32–91). 51 patients were female. The mean angle between the TEA and the AP axis was 92.78° with a standard deviation of 2.51° (range 88° – 99°). The mean angle between the AP axis and the PCA was 95.43° with a standard deviation of 2.75° (range 85° – 105°). The mean angle between the TEA and the PCA was 2.78° with a standard deviation of 1.91° (range 0° – 10°).

We conclude that while there is a reproducible relationship between the differing femoral axes, there is a significant range in the relationship between the femoral axes. This range may lead to greater inaccuracy than has previously been appreciated when defining the rotation of the femoral component. There is most variation between the PCA and the AP axis. The TEA's relationship with the PCA and AP appears important in defining rotation. Due to the well accepted difficulty in defining the TEA intra-operatively, there may be a role for patient-specific instrumentation in TKA surgery with pre-operative MRI.

Total knee arthroplasty (TKA) is an established and successful operation. However patient satisfaction rates vary from 81 to 89% 1,2,3. Pain following TKA is a significant factor in patient dissatisfaction 1. Many causes for pain following total knee arthroplasty have been identified 4 but rates of unexplained pain vary from 4 to 13.1% 5,6. Recently computerised tomography (CT) has been used to assess the rotational profile of both the tibial and femoral components in painful TKA

We reviewed 57 patients with an unexplained painful following TKA and compared these to a matched control group of 60 patients with TKA. Datum gathered from case notes and radiographs using a prospective database to identify patients. The CT information recorded was limb alignment, tibial component rotation, and femoral component rotation and combined rotation.

The two matched cohorts of patients had similar demographics. A significant difference in tibial, femoral and combined component rotation was identified between the groups. The following mean rotations were identified for the painful and control groups respectively. Tibial rotation was 3.46 degrees internal rotation (IR) compared to 2.50 degrees external rotation (ER)(p=0.001). Femoral rotation was 2.30 IR compared to 0.36 ER(p=0.02). Combined rotation was 7.08 IR compared to 2.85 ER(p=0.001).

This is the largest study presently in the literature. We have identified significant internal rotation in a patient cohort with unexplained painful TKA when compared to a matched control group. Internal rotation of the tibial component, femoral component and combined rotation was identified as a factor in unexplained pain following TKA.

Purpose

The purpose of this study is to investigate the relationship between the angles made by the reference axes on the computerized tomography (CT) images and comparison of the knee alignment between healthy young adults and patients who is scheduled to have total knee arthroplasty.

Three distal femoral axes have been described to aid in alignment of the femoral component; the Trans Epicondylar Axis (TEA), the Posterior Condylar Axis (PCA) and the Antero Posterior (AP) axis. Our aim was to identify if there was a reproducible relationship between the axes. Hopefully this will aid the surgeon to more accurately judge the rotation of the femoral cutting block by using the axes with the least variation. This is the first study compare all three distal femoral axes with each other using magnetic resonance imaging (MRI) in a Caucasian population awaiting total knee arthroplasty (TKA).

We identified the relationship between these axes by performing MRI scans on 89 patients awaiting TKA with patient-specific instrumentation. Measurements were taken by two observers.

Patients had a mean age of 62.5 years (range 32–91). 51 patients were female. The mean angle between the TEA and AP axis was 92.78°, standard deviation (SD) 2.51° (range 88°–99°). The mean angle between the AP axis and PCA was 95.43°, SD 2.75° (range 85°–105°). The mean angle between the TEA and PCA was 2.78°, SD 1.91° (range 0°–10°).

We conclude that while there is a reproducible relationship between the differing femoral axes, there is a significant range in the relationship between the femoral axes. This range may lead to greater inaccuracy than has previously been appreciated when defining the rotation of the femoral component. There is most variation between the PCA and the AP axis. Most systems have a cutting block with 3° of external rotation from the PCA and this would be parallel to the TEA in the majority, but not all, cases in this series. This data suggests that if the surgeon is to pick two axes to reference from, one should include the TEA.

The rotational alignment of the tibia is an as yet unresolved issue for arthroplasty surgeons. Functional variation may be due to minor malrotation of the tibial component. The aim was to find a reliable method for positioning the tibial component in arthroplasty.

CT scans of 21 knees were reconstructed in three dimensions and oriented vertically. A plane was taken 20 mm below the tibial spines. The centre of each tibial condyle was calculated from points taken round that condylar cortex. A tibial tubercle centre was also generated as the centre of the circle that best fit points on the surface of the tubercle in the plane of its most prominent point.

The derived points were identified by three observers with errors of 0.6 – 1mm. The medial and lateral tibial centres were constant features (radius 24mm ± 3mm, and 22mm ± 3mm respectively). An ‘anatomic’ axis was created perpendicular to a line joining these two points. The tubercle centre was found 20mm ± 7mm lateral to the medial tibial centre. Compared to this axis, an axis perpendicular to the posterior condylar axis was internally rotated by 6° ± 3°. An axis based on the tibial tubercle and the tibial spines was also internally rotated by 6° ± 10°.

We conclude that alignment of the knee when based on this ‘anatomic’ axis is more reliable than either of the posterior surfaces. It is also more reliable than any axis involving the tubercle, which is the least reliable feature in the region. The ‘anatomic’ axis can be used in navigated knee arthroplasty for referencing the rotational alignment of the tibial component.

Successful total knee arthroplasty (TKA) is dependent on the correct alignment of implanted prostheses. Major clinical problems can be related to poor femoral component positioning, including sagittal plane and rotational malalignment. A prospective randomized study was designed to test whether an optical navigation system for TKA achieved greater implantation precision than a non navigated technique. The primary variable was rotation of the femoral component in the transverse plane measured from post operative radiographs and CT images. Sixty-four patients were included in the study. All patients received the Duracon total knee prosthesis. The patients were randomly divided into two groups; Group C patients underwent conventional TKR without navigation, Group N patients underwent TKR using a computer assisted Knee Navigation System. Analysis revealed that patients in Group N had significantly better rotational alignment and flexion angle of the femoral component than patients in Group C. In addition, superior post operative alignment of the mechanical axis, posterior tibial slope, and rotational alignment was achieved for patients in Group N. The use of a navigation system provides improved alignment accuracy. Specifically, it can help to avoid femoral malrotation and errors in axial alignment.

Purpose

To investigate the tibiofemoral rotational profiles during surgery in navigated posterior-stabilized (PS) total knee arthroplasty (TKA) and investigated the effect on postoperative maximum flexion angles.

INTRODUCTION

Rotational malalignment of the components in total knee arthroplasty has been linked to patellar maltracking, improper soft tissue balance, abnormal kinematics, premature wear of the polyethylene inlay, and subsequent clinical complications such as anterior knee pain (Barrack et al., 2001; Zihlmann et al., 2005; Lakstein at al., 2010). This study investigates an innovative image-based device that is designed to be used along with an intraoperative Isocentric (ISO-C) 3D imaging C-arm, and the conventional surgical instruments for positioning the femoral component at accurate rotational alignment angles.

Total knee arthroplasty is an established and successful operation. In up to 13% of patients who undergo total knee arthroplasty continue to complain of pain. Recently computerised tomography (CT) has been used to assess the rotational profile of both the tibial and femoral components in painful total knee arthroplasty.

We reviewed 56 painful total knee replacements and compared these to 56 matched patients with pain free total knee replacements. Patients with infection, aseptic loosening, revision arthroplasties and gross coronal malalignment were excluded. Datum gathered from case notes and radiographs using a prospective orthopaedic database to identify patients. The age, sex, preoperative and postoperative Oxford scores, visual analogue scores and treatments recorded. The CT information recorded was limb alignment, tibial component rotation, femoral component rotation and combined rotation.

The two cohorts of patients had similar demographics. The mean limb alignments were 1.7 degrees varus and 0.01 degrees valgus in the painful and control groups respectively. A significant difference in tibial component rotation was identified between the groups with 3.2 degrees of internal rotation in the painful group compared to 0.5 degrees of external rotation in the control group (p=0.001). A significant difference in femoral component rotation was identified between the groups with 3.8 degrees of internal rotation in the painful group compared to 1.1 degrees of external rotation in the control group (p=0.001). A significant difference in the combined component rotation was identified between the groups with 6.8 degrees of internal rotation in the painful group compared to 1.7 degrees of external rotation in the control group (p=0.001).

We have identified significant internal rotation in a patient cohort with painful total knee arthroplasty when compared to a control group with internal rotation of the tibial component, femoral component and combined rotation. This is the largest comparison series currently in the literature.

Objective

Rotational malalignment of the femoral component still causes patellofemoral complications that result in failures in total knee arthroplasty (TKA). To achieve correct rotational alignment, a couple of anatomical landmarks have been proposed. Theoretically, transepicondylar axis has been demonstrated as a reliable rotational reference line, however, intraoperative identification of the transepicondylar axis is challenging in some cases. Therefore, surgeons usually estimate the transepicondylar axis from posterior condylar axis (PCA) using twist angle determined by the preoperative X-rays and CT. While PCA is the most apparent landmark, radiographs are not able to detect posterior condylar cartilage. In most osteoarthritic knees, the cartilage thickness of the posterior condyle is different between medial and lateral condyles. The purpose of this study is to evaluate the effect of the posterior condylar cartilage on rotational alignment of the femoral component in large number of arthritic patients. Furthermore, we investigated whether the effect of posterior condylar cartilage is different between osteoarthritis (OA) and rheumatoid arthritis (RA).

In total knee arthroplasty (TKA), rotational alignment of the femoral component is determined by the measured resection technique, in which anatomical landmarks serve as determinants, or by the gap balancing technique, in which the femoral component is positioned relative to the resected aspect of the tibia. The latter technique is considered logically more favorable for obtaining rectangular extension and flexion gaps. However, in patients with severe changes attributed to osteoarthritis and/or a severely limited range of motion, it is difficult to perform adequate posterior clearance (e.g. bone spur excision) before resecting the posterior femoral condyle, often causing unbalanced extension and flexion gaps after resection. Thus, the gap balancing technique is more technically demanding and requires higher skill. We employed a computed tomography (CT)-based navigation system to develop a simple and standardized surgical technique by performing two assessments: Assessment 1, we investigated the relationship between the position of the femoral component determined by the gap balancing technique and anatomical landmarks; and Assessment 2, we placed the femoral component at the position determined by the measured resection technique and within the acceptable gap-balanced range determined in Assessment 1. In Assessment 1, 18 knees with osteoarthritis were treated by posterior stabilized TKA for varus deformity. The extension-flexion balance after resection of the distal femoral condyle and the proximal tibia was within 3° in all cases. Posterior bone resection was performed parallel to the resected aspect of the tibia and at 90° of flexion under constant compression applied using a tensor. In other words, the rotational alignment of the femoral component was determined by the gap balancing technique, and its position relative to the posterior condylar axis (PCA) and clinical transepicondylar axis (CEA), which are landmarks in the measured resection technique, and the condylar twist angle (CTA; the angle between the CEA and PCA) were measured, and their relationships were quantitatively determined. The CTA, which was determined based on the preoperative CT data, was 4.7– 9.6° (mean, 7.05 ± 1.35°), while the aspect of the femoral resection was 3.0–8.3° externally rotated (mean, 5.6 ± 1.6°) to the PCA; a strong positive correlation was found between the rotational alignment of the femoral component and the CTA (p < 0.0001, R² = 0.871). The aspect of the femoral resection was 0.3–2.6° internally rotated (mean, 1.4 ± 0.6°) to the CEA, and no correlation with the CTA was apparent. In Assessment 2, 39 knees with an extension-flexion balance ≤3° were examined to determine the internal-external rotation balance. Based on the results of Assessment 1, we employed the measured resection technique and placed the femoral component by rotationally aligning the target, which was 1.4° internally rotated to the CEA. The final rotational alignment of the femoral component was 2.0 ± 0.6° internally rotated to the CEA; the internal-external rotation balance at 90° of flexion was good and more toward external rotation by 0.72 ± 1.61°. The results demonstrated that the measured resection technique enables placement of the femoral component within an acceptable range of rotational alignment.

The understanding of rotational alignment of the distal femur is essential in total knee replacement to ensure that there is correct placement of the femoral component. Many reference axes have been described, but there is still disagreement about their value and mutual angular relationship. Our aim was to validate a geometrically-defined reference axis against which the surface-derived axes could be compared in the axial plane. A total of 12 cadaver specimens underwent CT after rigid fixation of optical tracking devices to the femur and the tibia. Three-dimensional reconstructions were made to determine the anatomical surface points and geometrical references. The spatial relationships between the femur and tibia in full extension and in 90° of flexion were examined by an optical infrared tracking system.

After co-ordinate transformation of the described anatomical points and geometrical references, the projection of the relevant axes in the axial plane of the femur were mathematically achieved. Inter-and intra-observer variability in the three-dimensional CT reconstructions revealed angular errors ranging from 0.16° to 1.15° for all axes except for the trochlear axis which had an interobserver error of 2°. With the knees in full extension, the femoral transverse axis, connecting the centres of the best matching spheres of the femoral condyles, almost coincided with the tibial transverse axis (mean difference −0.8°, SD 2.05). At 90° of flexion, this femoral transverse axis was orthogonal to the tibial mechanical axis (mean difference −0.77°, SD 4.08). Of all the surfacederived axes, the surgical transepicondylar axis had the closest relationship to the femoral transverse axis after projection on to the axial plane of the femur (mean difference 0.21°, SD 1.77). The posterior condylar line was the most consistent axis (range −2.96° to − 0.28°, SD 0.77) and the trochlear anteroposterior axis the least consistent axis (range − 10.62° to +11.67°, SD 6.12). The orientation of both the posterior condylar line and the trochlear anteroposterior axis (p = 0.001) showed a trend towards internal rotation with valgus coronal alignment.