Purpose of the study: To develop a new treatment algorithm for patients with chronic anterior knee pain based on kinematic patella tracking MR imaging.

Methods and Results: Patients with anterior knee pain of more than one year duration and not responding to non-operative treatment, underwent kinematic MRI study. The provocative test was performed with the conventional MRI scanner and the patient extending the knee against resistance, the resistance provided by inflated beach ball. A retrospective analysis was done of first seventy patients, who had undergone this scanning technique.

On the imaging films, four measurements were made. They were patella subluxation, tilt, cartilage thickness and the Tibial Tubercle Trochlear distance (TTD). Patellar subluxation was classified as mild, moderate and severe. We found that a Tibial Tubercle Trochlea distance of 18mm had a specifity of 100% and a sensitivity of 89% for severe maltracking.

Conclusion: Kinematic MR Imaging is a useful investigation before considering operative treatment for patients with chronic anterior knee pain. Based on our study, we conclude that those patients with moderate lateral maltracking with a TTD< 18 mm should be offered lateral release and those with severe maltracking and TTD> 18mm should have a tibial tubercle transfer, in addition to lateral release.

Introduction. There has been a recent major increase in the use of unicompartmental knee replacement (UKR) but few studies exist comparing its long term efficiency with total knee replacement (TKR)

Method. Ethical approval was obtained.

Between 1989 and 1992 a randomised prospective study was undertaken in which 102 cases adjudged suitable for UKR were allocated to receive either a St Georg Sled UKR or a Kinematic Modular TKR. Both cohorts had a median age of 68 and a similar sex distribution and preoperative knee score. Regular follow up has been maintained. As reported the early results favoured UKR. All cases have now been assessed after a minimum of 10 years using modified WOMAC, Oxford and Bristol Knee Scores (BKS) as well as radiographs.

Results. 28 cases had died with their knees known to be intact, 2 cases were untraceable. 33 knees in each group were reviewed. 3 in each group had been revised, no impending failures were identified on the radiographs.

At 10 years the UKR group had better Oxford and WOMAC scores as well as significantly more excellent results (19:14) and fewer fair and poor results on the BKS. Both groups averaged over 105′ of flexion but 61% of the UKR and only 15% of the TKR group had 120′ or more of flexion.

Conclusion. The faster rehabilitation and better early results with UKR are maintained for 10 years with few failures occurring. The average BKS of the UKR group only fell from 91 to 88 between 5 and 10 years suggesting minimal evidence of functional deterioration in either the prosthesis or the remainder of the joint.

Introduction and Aims: Single compartmental replacement procedures are increasingly preferred over total knee replacement (TKR) for single compartment osteoarthritis of the knee joint. Theoretically, reduced disruption of the native joint should produce more normal kinematics. This study aimed to describe and compare the sagittal plane kinematics of four different, commonly used devices.

Method: Four groups of patients who had undergone successful single compartment replacement at least two years previously were recruited. Fifteen following Oxford medial UKA, 12 following medial St Georg Sled UKA, five following Oxford lateral UKA, and 12 following Avon PFJ replacement. Patients performed flexion/extension against gravity, and a step-up during video fluoroscopy. The Patellar Tendon Angle (PTA), the angle between the long axis of the tibia and the patella tendon, was obtained as a function of knee flexion. This relationship provides indication of sagittal movement between femur and tibia through range and has been validated as a reliable measure of joint kinematics.

Results: The kinematic profile for each group was compared to that of the profile for 12 normal and 30 TKR (AGC) knees. All three tibiofemoral devices produced knee kinematics similar to the normal knee. The PTA was found to have a linear relationship to flexion angle, decreasing with increasing knee flexion angle. No such linear relationship exists for the TKR joint, which display abnormal kinematics. The PF device also reflected similar trends to that for normal knees except that the PTA was moderately increased throughout the entire range of flexion (three degrees).

Conclusion: In contrast to TKR, all single compartmental knee replacements provided kinematics similar to the normal joint. The kinematic pattern of the PFJ replacement may be of most interest as the observed increase in PTA through range could influence patello-femoral contact forces

Introduction: Uni-compartmental Knee Replacement (UKR) has now become an accepted and widely used treatment for uni-compartmental arthritis. Our unit has performed over 1000 UKRs in the past 22 years. The optimal mechanical design of the implant has yet to be determined.

Method: A prospective trial was commenced in 1999 to compare the short-term results of a fixed bearing with a mobile bearing prosthesis. One hundred and three knees in 95 patients underwent a UKR. Fifty-three had a St Georg Sled fixed bearing prosthesis and 50 had unconstrained mobile bearing Oxford UKR. All were prospectively reviewed using the Oxford and Bristol Knee Scores.

Results: Eighty-four knees have been reviewed at two years with one lost to follow-up. One fixed (2%) and six mobile (12%) bearing knees had been revised. Three fixed bearing and eight mobile bearing knees were dissatisfied because of stiffness or persistent pain and seven mobile bearing knees had undergone further minor procedures, usually for dislocation. At two years, the Bristol and Oxford knee scores for fixed bearing were better than the mobile bearing knees at 90:83 /100 and 38:33 /48 respectively.

Conclusion: There were more early complications in the mobile bearing UKR group, but the functional results were slightly better than in the fixed bearing knees.

Introduction and Aims: There has recently been an increase in the use of uni-compartmental knee replacement (UKR), but there are few studies comparing its long-term efficacy and survival with total knee replacement (TKR). We reported the five-year results of a randomised trial which showed that uni-compartmental replacement had a faster rehabilitation and better functional results than total replacement. We now report the 10-year results.

Method: After obtaining ethical approval, between 1989 and 1992, 102 cases judged suitable for UKR were randomly allocated to receive either a St Georg Sled UKR or a Kinematic Modular TKR. Both cohorts had a median age of 68 and a similar sex distribution and pre-operative knee scores. Regular follow-up has been maintained. All cases have now been assessed after a minimum of 10 years using modified the WOMAC, Pain, Oxford and Bristol Knee (BSK) scoring systems as well as radiographs.

Results: At 10 years, 29 cases had died with their knees known to be intact, two totals cases were untraceable. Thirty-two uni`s, and 34 totals were available for review. Three uni`s (6%) and two totals (4%) had been revised; there was one impending total failure on the radiographs.

The UKR group had better scores with Oxford: 38 v 34 /48 and WOMAC: 17 v 21 /60 and more excellent results (19 v 14) and fewer fair and poor results on the BKS (4 v 6). The range of movement improved in UKA`s from 107 degrees to 117 degrees, whereas the range decreased in TRK`s from 107 degrees to 104 degrees. Sixty-one percent of the UKR and only 16% of the TKR group had more than 120 degrees of flexion.

Conclusion: The St Georg Uni-compartmental arthroplasty continues to function well at 10 years, with better functional scores and a better range of movement than the Kinematic Total arthroplasty. There were similar failures in both groups.

Introduction: Isolated patello-femoral arthritis occurs in up to 10% of patients suffering osteoarthritis of the knee. Reports of patello-femoral replacements have given indifferent results so we wish to report our experience of 326 cases using two different protheses.

Method: In 1989 we started a prospective series of the Lubinus prosthesis. The results of 76 cases at eight years showed a 50% failure rate. The main reasons for failure were malalignment, wear and disease progression. The Avon patello-femoral arthroplasty was designed to solve some of these problems.

Since September 1996, 250 knees have been treated. Prospective review was undertaken and 120 knees have reached two years and 40 are at five years. The outcome was assessed using pain scores, Bartlett’s patella score and the Oxford knee score.

Results: The median pain score improved from 15/40 points to 35 at five years. The movement increased from 114 to 120 degrees at five years. The Bartlett patella score improved from 10/30 points to 26 at five years. The Oxford knee score improved from 19/48 points to 40 points at five years.

The functional results are similar to those of a total knee replacement. Two patients developed malalignment (1%) one of which required distal soft tissue realignment. There have been no cases of deep infection, fracture, wear or loosening. Sixteen knees (6%) developed evidence of disease progression, 14 of which (6%) have required revision to a total knee replacement.

Conclusions: Results to date suggest that this improved design has reduced the problems of malalignment and early wear. There is a low complication rate and an excellent range of movement. Disease progression remains a problem that is not predictable. This type of prosthesis offers an alternative to total knee replacement in this small group of patients with isolated patello-femoral disease with a lower morbidity.

Introduction and Aims: Our experience with over 200 cases of Avon patellofemoral replacement (PFR) in the elderly with severe arthritis has been satisfactory, so we have extended the indications to younger patients with severe symptoms and various pathologies.

Method: Sixty-six knees in 53 patients (10M: 46F) under the age of 55 years (average 47 years) have been treated with an AVON PFR for the following conditions:

PATHOLOGY NUMBER of Knees

Isolated lateral facet OA 34

Failed realignment 12

Persistent subluxation/dislocation 5

Trochlear dysplasia 5

Pure chondral disease 3

Failed carbon fibre implant 3

Post-patellectomy instability 3

Post-traumatic pain 1

All patients were recorded prospectively and have been regularly reviewed using the modified Oxford, Bartlett & Bristol Knee scoring systems. The mean follow-up of the group is 24 months.

Results: No patient has been lost to follow-up, all knee scores improved substantially.

Most of the patients retained their range of flexion and the mean range of movement increased from 112 to 122 degrees. Patients with persistent subluxation were the most dramatically improved. There have been no cases of deep infection, loosening or wear.

Conclusion: Avon PFR provides a reliable short-term solution to some of the more difficult and disabling problems of the patello-femoral joint as long as demonstrable pathology is present.

Introduction and Aims: Kneeling is an important function of the knee joint but little information is available on ability to kneel after different types of knee arthroplasty. We aimed to assess patients’ kneeling ability pre- and post-operatively after uni-compartmental, patellofemoral and total knee arthroplasty (UKR, PFR, TKR) and to objectively examine: kneeling ability, factors that affect it and whether this ability differed from the patient’s perception.

Method: In 253 knee arthroplasty cases, we prospectively analysed the ability to kneel pre-operatively, and post-operatively at one and two years using the relevant section of the Oxford Knee Score questionnaire. One hundred and twenty-two post-operative patients (38 TKR, 53 UKR, 31 PFR) were then examined to assess their actual kneeling ability.

Results: Patients’ perception of their kneeling ability prior to surgery was poor in all three groups (mean score 0.7 out of 4) and improved in all groups after surgery (mean score at two years 1.46 out of 4). Perceived kneeling ability was best in UKR and worst in PFR (P< 0.001). Perceived kneeling ability improved most in the first year post-operatively, but continued to improve between one and two years although the final kneeling function was still not good. When examined, only 37% of patients thought they could kneel, whereas 81% were actually able to kneel (P< 0.001). Ability to kneel was significantly better than perceived ability for all prosthesis types (P< 0.001). Kneeling ability was better in men and associated with an increased range of movement (P< 0.001).

Conclusion: Kneeling ability is poor prior to knee arthroplasty and improves up to two years post-operatively, though it is still perceived to be poor, but can be improved with rehabilitation. UKR gave better kneeling ability than PFR or TKR. Patient-centred questionnaires do not accurately document kneeling ability after knee arthroplasty.

Purpose This study was carried out to compare the alteration in skin sensation following midline, medial and short medial incisions for knee replacement.

Method 88 patients with 102 knees were examined for altered skin sensation over the front of the knee, all were at least 18 months from their knee replacement. Twenty-one knees had a medial incision, 38 a midline incision and 43 a short medial incision for UKR.

A scale of −2 to +2 was used to measure different degrees of skin hypo or hyperaesthia. A purpose-designed grid, designed to fit different knee sizes, was used to record sensations. A computer programme was created to record all patients’ data including the length and shape of the incision in relation to anatomical landmarks.

A parallel histological study was carried out on 12 skin specimens taken from the 2 standard incisions. The specimens were prepared and stained for nerve endings. The number of nerve endings in each incision was calculated.

Results The average length for the medial incision was 17 cm with an average post-operative time of 3.37 yrs and skin numbness of 87.78 cm square.

The midline incision average length was 17.85 cm with an average post-operative time of 4.7 yrs and a numb area of 73.7 cm square.

The short medial incision used for UKR averaged to be 9 cm in length with an average post operative time of 3.9 yrs and an area of numbness of 48.1 cm square.

Histologically less cutaneous nerve endings were seen in specimens from midline incisions than medial incisions.

Discussion The midline line incision seems to produce less dermal parasthesia than the medial incision, this probably relates to both the wound position and the density of nerve endings. The length of the incision correlated with the area of numbness when comparing the short and long medial incisions.

Purpose: To assess the outcome of customised hinged knee replacements when used to salvage catastrophically failed knee replacements in elderly patients.

Methods: Since 1993, 30 of the 280 (10.7%) revision knee replacements at the Avon Orthopaedic Centre, Bristol have used Endo customised hinged knee pros-theses (21 rotating, 9 fixed) for salvage of limb threatening situations in elderly patients. All were prospectively recorded and regularly reviewed. The average age was 75 years with a predominance of females. Surgical indications were 22 periprosthetic fractures (with or without aseptic loosening), 5 massive aseptic osteolyses, and 3 deep infections.

Results: The mean length of postoperative hospital stay was just 14.6 days and all patients were discharged walking with aids. At follow up (mean 3.0 years, range 0.5–9.3 years) 9 patients had died with their prostheses in situ and functioning. 2 had undergone amputation for recurrent sepsis and 2 had received further surgery for septic problems. 2 patients required further surgery for prosthetic disarticulation and one patient had successful on table vascular repair. 25 patients had mid or long term follow up. Their mean American Knee Scores (AKS) were 69.8 for knee and 35.6 for function (maximum 100), with a mean total knee flexion of 83 degrees. Mean Oxford knee scores (OKS) and WOMAC scores (both scored between 12 and 60 with low score indicating less difficulties) were 34.0 and 30.5 respectively.

Conclusions: Customised hinge revision knee replacements gave extremely rapid rehabilitation and hospital discharge which justified the high prosthetic cost. Complications were high but at mid and long-term review, no prostheses had failed from an aseptic cause and most of the knees of this challenging group were providing both stability and flex

Purpose of the study: To develop a new treatment algorithm for patients with chronic anterior knee pain based on kinematic patella tracking MR imaging.

Methods and Results: Patients with anterior knee pain of more than one year duration and not responding to non-operative treatment, underwent kinematic MRI study. The provocative test was performed with the conventional MRI scanner and the patient extending the knee against resistance, the resistance provided by inflated beach ball. A retrospective analysis was done of first seventy patients, who had undergone this scanning technique.

On the imaging films, four measurements were made. They were patella subluxation, tilt, cartilage thickness and the Tibial Tubercle Trochlear distance (TTD). Patellar subluxation was classified as mild, moderate and severe. We found that a Tibial Tubercle Trochlea distance of 18mm had a specifity of 100% and a sensitivity of 89% for severe maltracking.

Conclusion: Kinematic MR Imaging is a useful investigation before considering operative treatment for patients with chronic anterior knee pain. Based on our study, we conclude that those patients with moderate lateral maltracking with a TTD< 18 mm should be offered lateral release and those with severe maltracking and TTD> 18mm should have a tibial tubercle transfer, in addition to lateral release.

Aim: The aim of this study was to evaluate the functional results and ease of performing revision surgery after a primary unicompartmental arthroplasty versus primary total knee arthroplasty.

Method: 114 revision TKRs had data collected prospectively as part of our unit’s Knee Database. 45 were revisions of UKR’s and 79 revisions of TKR’s. This data included Bristol Knee Scores (BKS), reason for revision, use of implant augments and bone graft. Measurements were also made of the ability to restore joint-line after revision.

Results: In both groups there was a significant improvement in BKS post-operatively. In the UKR group the commonest reason for revision was progression of disease, while in the TKR group it was aseptic loosening. Bone graft was required in significantly fewer UKR cases (20% vs 40%, P< 0.05). Distal femoral augments were used in 45% of the TKR revisions but in none of the revisions from UKR. The joint line was elevated in a significantly higher proportion of revision from TKR cases versus revision from UKR cases (P< 0.001). Revisions from UKR had higher Total BKS and Functional BKS score than revisions from TKR.

Conclusions: Revision TKR after a primary UKR requires less bone graft, fewer augments, restores the joint line more frequently and gives improved functional results over revisions after primary TKR.

Purpose A new design of patello-femoral arthroplasty has been used to treat patients under 55 years suffering severe symptoms from chondral and early arthritic disease of the patello-femoral joint.

Materials and Methods and Results Fifty-two patello-femoral arthroplasties were performed in 45 patients under the age of fifty-five years when other treatments had failed. The average age was 48 years (range 36–54 years). Thirty-seven cases had undergone previous surgery for a variety of conditions, and the causes of the disorders were analysed. Results were assessed using pain scores and Bartlett’s and Oxford functional scores. 35 cases were reviewed at 8 months and 22 cases at two years. The median pain score improved from 10/40 points to 35 at two years. The Bartlett score increased from 10/30 points to 27 and the Oxford score from 19/48 points to 35 at two years. The range of movement increased from 114° to 121°. There have been no cases of deep infection, loosening, wear or instability. Disease progression, a potential risk has occurred in one case.

Conclusions This prosthesis offers a solution in younger patients with disabling symptoms of isolated early patello-femoral disease who have not responded to conservative surgical management.

The study was designed to compare the clinical performance of an Alumina ceramic acetabular bearing to that of a polyethylene bearing in a cementless hip couple.

The study group consisted of 15 surgeons who performed 308 total hip replacements (297 patients) between January 29, 1998 and February 1, 2000. All patients received a porous coated cementless titanium stem with an Alumina ceramic 28 mm or 32 mm head. Patients were randomized to receive a porous titanium acetabular shell with either a polyethylene or Alumina cup liner. There were 164 Alumina cups and 144 polyethylene cups. The mean age was 57.3 years and consisted of 50% males and 50% females. The preoperative diagnoses were: osteoarthritis 69.8%, avascular necrosis 19.5 %, post traumatic arthritis 2.9 %, inflammatory arthritis 3.9% and other 3.9%. The mean follow up was 12 months. The longest follow up was 38 months.

The Harris Hip Score was good and excellent in 86% of the control patients and 87% of the study patients. There has been 100% follow up and survivorship.

There were two reoperations for recurrent dislocations in each group. There were no Alumina component fractures, no progressive radiolucencies and no evidence of rapid wear.

In the short term follow-up between 12 and 38 months, there do not appear to be any differences between the patients with a bearing couple consisting of Alumina on plastic with those consisting of Alumina on Alumina. There have been no catastrophic failures of the ceramic components. The Alumina/Alumina bearing couple for total hip arthroplasty appears to be an excellent alternative bearing, providing the advantage of improved long term wear and a reduced incidence of polyethylene induced osteolysis.

Aim: To assess the functional results of revision TKR with the PFC/TC3 system, and to correlate this with the reasons for revision and restoration of joint height. Method: 153 patients underwent revision TKR using the PFC/TC3 system. Data was prospectively collected (using the Bristol Knee Score) pre-operatively and at a mean of 4.2 years post-revision. 43 revisions were for infection and 81 revisions were for aseptic loosening. Measurements of the joint height were made pre and post-operatively using FiggieÔs method and were divided into 3 groups: lower by more than 5mm, restored and elevated more than 5mm. Use of distal augments and polyethylene thickness were recorded. Results: The mean pre-op function score was 12 and post-operatively was 19 for the infection group and 20 for the aseptic loosening group. Revision after initial UKR gave a mean score of 21, while revision after TKR gave a mean score of 18 (max 27). Knees in which the joint line was elevated by more than 5 mm had a mean score of 17 while those where the joint line was restored had a mean score of 19. Recent increasing use of distal augments improved the joint line and results. Conclusion: revision using the PFC/TC3 system produced acceptable medium term functional results and good survival. Better restoration of joint line and functional results were achieved by distal femoral rather than proximal tibial augmentation.

Aims: To investigate whether normal statistical ßuctuation in the incidence of early complications of primary Knee Arthroplasty (TKA) follows the laws of statistical probability and can thus be amenable to analysis by standard Statistical Quality Control (SQC) methods. The þnal objective is to apply such techniques to distinguish random ßuctuation from real (undetected by traditional p value statistical methods) increase in the incidence of early complications in primary joint Arthroplasty. Methods: We employed statistical quality control charts (X-bar, p, c, u and np) to analyse postoperative complications and length of stay in 1,196 consecutive primary TKAs performed over a 20-quarter time period (October 1995 to September 2000). For all analyses (Minitab 12.1 software) the standard practice of employing ± 3 standard deviation upper and lower control limits and generally accepted criteria for determining the presence or absence of statistical control were used. Results: Deep infection, major thromboembolic incident, total number of complications per case and total number of complicated cases appeared to be in stable statistical control and followed the laws of statistical ßuctuation throughout the entire study period. However, patella mal-tracking, persistent knee stiffness, postoperative length of stay and total number of postoperative complications showed an (undetected by conventional postoperative audit methods) lack of control at various time periods with subsequent return to the statistically-controlled range. Conclusions: SQC methods may be employed in the audit of postoperative events in TKA and can be a valuable tool in continuous assessment of the statistical variability of postoperative complications, with the aim of reducing the variability and improving clinical outcome Arthritic knee imaging

Aims: To compare the intraoperative cerebral microemboli load between primary total hip (THA) and knee arthroplsty (TKA) using transcranial Doppler ultrasound and to investigate whether a patent foramen ovale influences cerebral embolic load in general. The timing of the microemboli will be related to certain surgical activities to determine if a specific relationship exists. Methods: Patients undergoing primary TKA or THA, with no history of stroke, TIA, ongoing CNS disease or alcoholism included. All operations carried out under a standardised general anaesthetic and performed by two consultant orthopaedic surgeons. Microemboli load recorded, using transcranial Doppler ultrasound (TCD), onto VHS tape for subsequent playback and analysis. Patent foramen ovale detection performed using bolus intravenous injection of agitated saline followed by valsalva manoeuvre technique and TCD. Timing of specific surgical steps recorded for each operation and emboli load calculated for that period. Results: 20 THA and 20 TKA patients were studied. Cerebral microembolisation occurred in 50% of THA and 40% of TKA patients. Total microembolic load for THA patients was 137 (range=0–83) and 50 (range=0–21) for TKA patients. Prevalence of PFO in the THA group was 35%, and 20% in the TKA group. 57.1% of PFO positive THA patients and 75% of PFO positive TKA patients displayed microemboli. Insertion of the femoral component in THA and release of the tourniquet in TKA were associated with higher cerebral microemboli load. Conclusion: Intraoperative cerebral microembolisation occurs in almost half of patients during hip and knee arthroplasty. Patients who have a PFO appear more likely to be associated with cerebral embolisation. Specific surgical activities are associated with larger embolic loads.

Introduction: Lateral uni-compartmental knee replacement (UKR) is seldom indicated and remains controversial. It has been considered a technically challenging operation with variable success. Aim: The aim of this paper is to assess the results of unicompartmental knee replacement using a þxed noncongruous prosthesis. Methods: Eighty-eight knees in 79 patients with lateral unicompartmental osteoarthritis treated with a þxed bearing, non-congruous, fully unconstrained prosthesis. (St Georg Sled UKR) over a period of 21 years by different consultants and there trainees. Surgical approach and rehabilitation protocol varied over this period but there was no change in the surgical indications. Results: At a mean follow up of 9 years (range 2 to 21 years). Fifteen knees had revision surgery (9 for progression of arthritis and 6 for component loosening, 4 for implant breakage and 4 for more than one reason). Six patients complained of moderate or severe pain at þnal follow up. Only þve knees were lost to follow up in the 21-year period. Survivorship analysis was performed on the group using revision for any cause as the end point. At ten years the cumulative survival rate was 83% and at 15 years, when ten knees were still at risk, the cumulative survival rate was 74%. Conclusion: Based on our clinical results and survival rate the St Georg Sled UKR can be considered a suitable treatment for isolated lateral compartment osteoarthritis.

The diagnosis and subsequent treatment of patients with “Anterior Knee Pain” remains a challenge and an enigma at times.

The 4 main parameters, which need to be assessed, are:

Bony anatomy of the PFJ

While plain radiographs, CT scans and static MRI sans and arthroscopic assessments highlight some of the parameters none of them are comprehensive. The type of MRI scanning used in this study assesses all 4 parameters. The equipment required for resisted quadriceps contraction is inexpensive and readily available.

Material and Methods: 70 patients had dynamic MRI scans done over a period of 2 years. The study consisted of 3 parts:

Radiological diagnosis and grading of subluxation if present.

Conclusion: The Tibial Tubercle to Trochlear Groove Distance” (TTD) appears to be the single most significant parameter determining patellar tracking. Objective radiological assessment is possible under physiological loading, to differentiate tilt, subluxation and chondromalacia. We have proposed an algorithm for the surgical and non-surgical treatment of anterior knee pain. The pain scores did not show a significant correlation with the grading of subluxation.

Aims: To quantify the intraoperative cerebral microemboli load during primary total hip arthroplasty (THA) using transcranial Doppler ultrasound and to investigate whether a patent foramen ovale influences cerebral embolic load in general. The timing of the microemboli will be related to certain surgical activities to determine if a specific relationship exists.

Methods: Patients undergoing primary THA, with no history of stroke, TIA, ongoing CNS disease or alcoholism were included. All operations were carried out under a standardised general anaesthetic and performed by two consultant orthopaedic surgeons. Microemboli load was recorded, using transcranial Doppler ultrasound (TCD), onto VHS tape for subsequent playback and analysis. Patent foramen ovale detection was performed using bolus intravenous injection of agitated saline followed by valsalva manoeuvre technique and TCD. Timing of specific surgical steps was recorded for each operation and emboli load calculated for that period.

Results: 25 THA patients were studied (18 females, 7 males) 16 right and 9 left THA’s were performed. Cerebral microembolisation occurred in 10 patients (40%). Mean microembolic load was 5.52 per patient (range = 0–83). PFO was detected in 8 patients (32%). 37.5% of PFO positive patients displayed cerebral microemboli. However, 41.1% of PFO negative patients also displayed microemboli intraoperatively.

Insertion of the femoral component was associated with generating a larger microembolic load than the other phases of the operation.

Conclusion: Intraoperative cerebral microembolisation occurs in a significant proportion of patients during total hip arthroplasty. The presence of a patent foramen ovale does not appear to influence the incidence microemboli intraoperatively. Specific surgical activities are associated with generating greater embolic loads. These questions will be comprehensively assessed in the larger study currently underway..