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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_3 | Pages 97 - 97
1 Jan 2016
Ogawa T Takao M Sakai T Nishii T Sugano N
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Puropose

Three-dimensional (3D) templating based on computed tomography (CT) in total hip arthroplasty improves the accuracy of implant size. However, even when using 3D-CT preoperative planning, getting the concordance rate between planned and actual sizes to reach 100% is not easy. To increase the concordance rate, it is important to analyze the causes of mismatch; however, no such studies have been reported. This study had the following two purposes: to clarify the concordance rate in implant size between 3D-CT preoperative planning and actual size; and to analyze risk factors for mismatch.

Materials and Methods

A single surgeon performed 149 THAs using Trident Cup and Centpillar Stem (Stryker) with CT-based navigation between September 2008 and August 2011. Minimal follow-up was 2 years. Patients with incomplete postoperative CT were excluded from this study. Based on these criteria, the study examined 124 hips in 111 patients (mean age, 60 years, mean BMI 23.2 kg/m2). The preoperative diagnosis was primary osteoarthritis in 8 hips, secondary osteoarthritis in 102 hips, osteonecrosis in 9 hips, rapidly destructive coxopathy in 4 hips and rheumatoid arthritis in 1 hip. We compared cup and stem sizes between preoperative planning and intraoperatively used components. Radiological evaluations were cortical index and canal flare index on preoperative X-rays. We evaluated preoperative planning and postoperative components for cup orientation, cup position, and stem alignment (anteversion, flexion and varus angle) on the CT-navigation system. Fixation of the stem was evaluated by X-ray radiography at 2 years postoperatively according to Engh's criteria. Statistical analysis was performed with the Mann-Whitney U test, and values of P<0.05 were considered statistically significant.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 84 - 84
1 Jan 2016
Uemura K Takao M Sakai T Nishii T Sugano N
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Introduction

Support cages are often used for reconstruction of acetabular bone defects in revision total hip arthroplasty. A Burch-Schneider cage is one of the most reliable systems that has shown good clinical results. It has an ischial flange and an iliac plate for screw fixation to the ilium. It is sometimes necessary to bend the flange or the plate to fit the shape of the peri-acetabulum. However, the frequency, indications, and characteristics of bending the flange or plate have not been reported. To clarify them, a simulation study was conducted.

Materials and methods

Twenty-five cases with acetabular bone defects of Paprosky type 2, 3, or 4 were the subjects of this study. A 3D template surgical simulation was conducted using 3D surface models of the Burch-Schneider cage and acetabulum. The size of the cage was determined by the size of the cavitary bone defect. Placement of the cage was performed in two ways. One was the iliac plate fitting method, in which fitting of the iliac plate to the ilium was performed first, followed by bending of the ischial flange to keep the flange in the center of the ischium. When bending of the flange was needed, it was bent at the base. The other method was the ischial flange fitting method, in which the ischial flange was inserted from the center of the ischium, followed by bending of the iliac flange to adapt to the ilium. When bending of the plate was needed, it was bent at the base. In both methods, the direction and angle of bending were measured.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 47 - 47
1 Jan 2016
Takao M Nishii T Sakai T Sugano N
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In total hip arthroplasty (THA), inappropriate cup alignment cause edge loading and prosthetic impingement, which lead to various mechanical problems including dislocation, excessive wear and breakage of bearing materials, and stem neck fracture. To find the optimal cup alignment, various computer simulation studies have been conducted. However there have been few studies focusing on pelvic coordinate system as a reference of cup positioning. Our hypothesis is that the functional pelvic coordinate system with pelvic sagittal inclination in the supine position is appropriate for a reference frame of cup alignment. To test the hypothesis, we have been investigating preoperative and postoperative kinematics of pelvis and hip of THA patients.

In 25 % of the consecutive 163 patients, the difference in preoperative pelvic inclination angle between the supine and standing positions (positional change of pelvic inclination [PC]) was 10o or more. Patients’ age and age-related spinal disorders including compression fracture and lumbar spondylolisthesis were independent factors associated with large preoperative PC. This raises a concern that large PC might increase the risk of edge loading and posterior prosthetic impingement when cup was positioned referencing supine pelvic position, especially in elderly patients.

We compared kinematics of the hip after THA in patients with a preoperative large PC (≥10°) with that in patients with a preoperative small PC (<10°), assuming that the supine position as a zero position of the pelvis. First, we compared intraoperative passive range of motion (ROM) after implantation of the 91 hips using navigation system. No significant differences in intraoperative hip ROM were observed between the both groups. Next, we compared postoperative ROM of the 50 hips during motion of daily livings using our 4-dimentional motion analysis system within two year after THA. No significant differences in postoperative hip flexion or extension angles were observed between the both groups. These results suggested that if cup was positioned referencing the supine pelvic position, the degree of preoperative PC does not matter early after primary THA.

Regarding long-term change of pelvic inclination after THA, 49 % of 70 patients followed for 10 years showed the change more than 10o in the standing position, although only 9% showed the change more than 10o in the supine position. This means that aging after THA increase discrepancy of pelvic inclination between the preoperative supine position as the reference for preoperative planning and the postoperative standing positions in some patients. However we could not find any preoperative predictors of this long-term change of pelvic inclination in the standing position. Therefore, although it is unclear whether surgeons should change the reference pelvic plane for cup alignment taking the longitudinal change of pelvic inclination in the standing position, at least, strict cup alignment control at primary THA is considered to be important to minimize the risk of edge loading and prosthetic impingement due to longitudinal changes of pelvic inclination.

In conclusion, our current recommendation of pelvic coordinate system as a reference of cup alignment is a functional pelvic coordinate system with pelvic sagittal inclination in supine position.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 36 - 36
1 Apr 2013
Matsui K Miyamoto W Tsuchida Y Takao M Matsushita T
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Background

Growing of the geriatric population has brought about increase of lower extremity fractures. The purpose of this study was to investigate the occurrence of surgical site infection after the surgery for lower extremity fractures, except proximal femoral fracture, in over eighty years old patients.

Methods

Patients with closed lower extremity fracture which were treated surgically in 2011 were divided into two groups (Group O; the equal or more than 80 years old, Group Y; from 20 to 65 years old), and the incidence of infection and the outcome after its treatment was compared between Group O and Group Y.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 343 - 343
1 Mar 2013
Sugano N Takao M Sakai T Nishii T Nakahara I Miki H
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Although there are several reports of excellent long-term survival after cemented total hip arthroplasty (THA), cemented acetabular components are prone to become loose when compared with femoral components. On the other hand, the survival of cementless acetabular components has been reported to be equal or better than cemented ones and the use of cementless acetabular components is increasing. However, most of the reports on survival after THA are for patients with primary hip osteoarthritis (OA) and there is no report of 20-year survival of cementless THA for patients with hip dysplasia. It is supposed to be more difficult to fix cementless acetabular components for OA secondary to hip dysplasia than primary OA. The purposes of this study were to review retrospectively the 20-year survival of cemented and cementless THA for hip dysplasia and to compare the effect of fixation methods on the long-term survival for patients with hip dysplasia. We retrospectively reviewed all patients with OA secondary to hip dysplasia treated with a cemented Bioceram hip system between 1981 and 1987, and a cementless cancellous metal Lübeck hip system between 1987 and 1991. We excluded patients aged more than 60 years, males, and Crowe 4 hips. The studied subjects were 70 hips of cemented THA (Group-C) and 57 hips of cementless THA (Group-UC). Both hip implants had a 28-mm alumina head on polyethylene articulation. The mean age at operation was 50.5 years (range, 36–60 years) in Group-C and 50.0 years (range, 29–60 years) in Group-UC. The mean BMI was 23.2 kg/m2 in Group-C (range, 17.3–29.3 kg/m2) and 22.9 kg/m2 in Group-UC (range, 18.8–28.0 kg/m2). There were no significant differences in age and BMI between the two groups. The average follow-up period was 18.0 years in Group-C and 18.4 years in Group-UC. In Group-C, revision was performed in 33 hips due to aseptic cup loosening (30 hips), stem loosening (one hip), and loosening of both components (two hips). In Group-UC, revision was performed in 10 hips due to stem fracture secondary to distal fixation (4 hips), cup loosening (three hips), polyethylene breakage (two hips), and extensive osteolysis around the stem (one hip). The survival at 20 years regarding any revision as the endpoint was 51% in Group-C and 84% in Group-UC. This difference was significant using Log-rank test (P=0.006). The cup survival at 20 years was 54% in Group-C and 92% in Group-UC. This difference was also significant (P = 0.0003). The stem survival at 20 years was 95% in Group-C and 92% in Group-UC. This difference was not significant (P = 0.4826). Cementless THA showed a higher survival rate at 20 years for hip dysplasia than cemented THA because of the excellent survival of the acetabular component without cement. We conclude that cementless THA with the cancellous metal Lübeck hip system led to better longevity at 20 years than cemented THA with the Bioceram for patients with OA secondary to hip dysplasia.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 121 - 121
1 Sep 2012
Nishii T Sakai T Takao M Yoshikawa H Sugano N
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Purpose

There are concerns of soft-tissue reactions such as metal hypersensitivity or pseudotumors for metal-on-metal (MoM) bearings in hip arthroplasty, however, such reactions around ceramic or polyethylene bearings are incompletely understood. The present study was conducted to examine the capabilities of ultrasound screening and to compare the prevalence of periarticular soft-tissue lesions among various types of bearings.

Methods

Ultrasound examinations were conducted in 163 hips (153 patients) with arthroplasty after mean a follow-up of 8.1 years (range, 1–22 years). This included 39 MoM hip resurfacings (M-HR) including 30 Birmingham hip resurfacings (BHR) and 9 ADEPT resurfacings; 36 MoM total hip arthroplasties (M-THA) with a large femoral head including 26 BHR and 10 ADEPT bearings; 21 ceramic-on-ceramic THAs (C-THA) of Biolox forte alumina bearings; 24 THAs with a conventional polyethylene liner (cPE-THA) including 19 Lubeck and 5 Omnifit systems; and 43 THAs with a highly cross-linked polyethylene liner (hxPE-THA) including 28 Crossfire and 15 Longevity liners. All procedures were performed in the lateral position through the posterior approach without trochanteric osteotomy. The M-HR group had a significantly higher frequency of male patients than the C-THA, cPE-THA, and hxPE-THA groups, and the patients in the M-HR group were younger than those in the other four groups. Ultrasound images were acquired as a still picture and in video format as the hip moved in flexion and rotation, and 4 qualitative classifications for periarticular soft-tissue reactions were determined as normal pattern, joint-expansion pattern (marked hypoechoic space between the anterior capsule and the anterior surface of the femoral component), cystic pattern (irregularly shaped hypoechoic lesions), and mass pattern (a large mass extending anterior to the femoral component). Magnetic resonance imaging (MRI) was subsequently performed in 45 hips with high-frequency encoding bandwidths. For the reliability of ultrasound screening, positive predictive value, negative predictive value, and the accuracy of the presence of abnormal patterns on ultrasound were calculated using the abnormal lesions on MRI as a reference.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 185 - 185
1 Sep 2012
Takao M Nishii T Sakai T Sugano N
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Introduction

Preoperative planning is an essential procedure for successful total hip arthroplasty. Many studies reported lower accuracy of two-dimensional analogue or digital templating for developmentally dysplastic hips (DDH). There have been few studies regarding the utility of three-dimensional (3D) templating for DDH. The aim of the present study is to assess the accuracy and reliability of 3D templating of cementless THA for hip dysplasia.

Methods

We used 86 sets of 3D-CT data of 84 patients who underwent consecutive cementless THA using an anatomical stem and a rim-enlarged cup. There were six men and 78 women with the mean age of 58 years. The diagnosis was developmental dysplasia in 70 hips and osteonecrosis in 14 hips and primary osteoarthritis in 2 hips. There were 53 hips in Crowe group I, 11 hips in Crowe group II and 6 hips in Crowe group III. Each operator performed 3D templating prior surgery using a planning workstation of CT-based navigation system. Planned-versus-achieved accuracy was evaluated. The templating results were categorized as either exact size or +/− 1 size of implanted size. To assess the intra- and inter-planner reliabilities, 3D templating was performed by two authors blinded to surgery twice at an interval of one month. Kappa values were calculated. The accuracy and the intra- and inter-planner reliabilities were compared between the DDH group (70 hips) and the non DDH group (16 hips).


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 186 - 186
1 Sep 2012
Takao M Nishii T Sakai T Sugano N
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Introduction

The shuck test was widely used to assess the overall soft-tissue tension around the hip joint during surgery. There have been few attempts to standardize how one evaluates soft tissue tension in total hip arthroplasty. The aim of this study was to ask how reliable the shuck test was as a measure of soft tissue tension in total hip arthroplasty.

Methods

First, we assessed the intra- and inter-examiner variability of the force generated in the shuck test. Next, we asked how the strength of traction forces and joint position on the distance of displacement of the prosthetic head at surgery. Twenty-one hip surgeons, consisting of seven experienced hip surgeons, seven junior hip surgeons, and seven surgeons in training were included in the first study. Test subjects were instructed to pull a traction gauge with their customary range of force. Each subject performed two sets of the shuck test in one week interval. Eighteen patients who had cementless THA through postero-lateral approach using 3D-CT based navigation system were enrolled in the second study. After implantation of components, the leg was pull caudally using our original device [Fig. 1]. The strength of applied traction force was 20 %, 30 %, 40 % and 50 % of body weight of each patient. The distance of displacement of a prosthetic head during traction was recorded at flexion angles of 0, 15, 30 and 45 degrees using the navigation system. Internal or external rotation of legs was controlled within 5 degrees.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 122 - 122
1 Sep 2012
Nishii T Sakai T Takao M Yoshikawa H Sugano N
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Purpose

Ceramic-on-ceramic bearings in total hip arthroplasty (CoC THA) have theoretical advantages of wear resistance and favorable biocompatibility of ceramic particles to the surrounding bony and soft tissue. Long-time durability of CoC THA has been expected, however, clinical results over 10 years after operation were scarcely reported. In the present study, clinical results at follow of 10 years were examined for CoC THAs with a changeable femoral neck which allowed correction of anteversion of the femoral component in cases with abnormal femoral anteversion in dysplastic hips.

Methods

During 1997 and 2000, 203 cementless CoC THAs in 158 patients were conducted in our hospital. Six patients died because of unrelated causes and 5 patients were lost to followup, and the remaining 188 hips in 147 patients were analyzed at the mean followup period of 10.8 years (3.7 to 13.5). There were 24 men and 123 women, and the average age at operation was 54 years (26 to 73). The hip diseases for operation were osteoarthritis in 165 hips, osteonecrosis of the femoral head in 21 hips and failure of hemiarthroplasty in 2 hips. The operation was performed in the lateral position through the posterior approach without trochanteric osteotomy. The articulation was composed of Biolox forte alumina liner fitted into beads-coated hiemispherical titanium shell, and a 28-mm Biolox forte alumina femoral head (Cremascoli). The femoral component was either AnCA stem or custom-designed stem, coupled with a modular neck allowing selection of 5 variable offsets and anteversions (Cremascoli). Clinical and radiological findings, and complications during the followup period were analyzed.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 167 - 167
1 Jun 2012
Nakasone S Takao M Nishii T Sakai T Nakamura N Sugano N
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Introduction

Current standard cups of metal on metal resurfacing hip arthroplasty (RHA) have no dome holes and it is very difficult for surgeons to confirm full seating of these cups. This sometimes results in gap formation between the cup and acetabular floor. Although the incidence of initial gaps using modular press-fit cups with dome screw holes has been reported to range from 20 to 35%, few studies have reported the incidence of gap formation with monoblock metal cups and its clinical consequences in RHA. The purpose of this study was to investigate retrospectively the incidence of initial gap formation and whether the initial gap influences the clinical results in RHA.

Material and Method

RHA was performed on 166 hips of 146 patients using the Birmingham Hip Resurfacing (BHR) (MMT, UK) between 1998 and 2007. Mean age at operation was 48.7 years (range, 19-85 years). Mean duration of follow-up was 6.9 years (2.0-10.6). Acetabular reaming was performed with the use of hemispherical reamers and the reamer size was increased up to an odd number diameter which provided tight rim fit in the antero-posterior direction. The same size hemispherical provisional cup with dome holes and slits was used to check the cavity for complete seating. If the provisional cup could not be seated on the floor, reaming was repeated with the same reamer to remove the rim bump until full seating was achieved. Acetabular cups of 1mm larger diameter were impacted into the acetabulum by a press-fit technique. After press-fit fixation, the stability of the cups was confirmed with a synchronized movement of the pelvis and the cup inserter by applying a gentle torque. Clinical evaluation was performed using WOMAC at the latest follow-up. Radiographic assessments were performed using radiographs immediately after the surgery, at 3 weeks, 3 months, 1 year, and then annually thereafter. We evaluated the height of the gap between the cup and acetabular surface, cup inclination angle, cup migration and the time to gap filling. To investigate the relationship between the magnitude of the gap and the radiographic results, the patients were divided into two groups according to the height of the initial gap; the cases with a gap of less than 3 mm on the initial radiograph were grouped into a small gap group, the cases with a gap of 3mm or more were grouped into a large gap group. We compared the changes in the height of the gap, in the cup inclination angle and the cup migration between the groups.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 166 - 166
1 Jun 2012
Nakahara I Bandoh S Takao M Sakai T Nishii T Sugano N
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Introduction

The initial mechanical stability of cementless femoral stems in total hip arthroplasty is an important factor for stable biological fixation. Conversely, insufficient initial stability can lead to stem subsidence, and excessive subsidence can result in periprosthetic femoral fracture due to hoop stress. The surface roughness of stems with a surface coating theoretically contributes to initial mechanical stability by increasing friction against the bone, however, no reports have shown the effect of surface roughness on stability. The purpose of this study was to evaluate the effect of differences in surface roughness due to different surface treatments with the same stem design on the initial stability.

Materials and Methods

Proximally titanium plasma-sprayed femoral stems (PS stem) and proximally grit-blasted stems (GB stem) were compared. The stem design was identical with an anatomic short tapered shape for proximal fixation. The optimum size of PS stem based on 3D templating was implanted in one side of 11 pairs of human cadaveric femora and the same size of GB stems was implanted in the other side. After implantation, the specimens were fixed to the jig of a universal testing machine in 25cm of entire length so that the long axis of the femur was positioned at 15-degrees adduction to the vertical. Vertical load tests were conducted under 1 mm/minute of displacement-controlled conditions. After 200 N of preload to eliminate the variance in the magnitude of press-fit by manual implantation, load was applied until periprosthetic fracture occurred.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIII | Pages 229 - 229
1 May 2012
Yasui Y Takao M Matsushita T
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There have been few reports with efficient treatments for neglected distal tibiofibular syndesmosis disruption. Here we will report four cases of successful anatomical reconstruction with autologous gracilis tendon, using the interference fit anchoring (IFA) system.

All four cases were males between 20 and 58 years of age at the time of surgery (mean age 36 years). The post-injury period to surgery was between 7 and 59 months (mean 20.1 months), with the consultation period being from 5 to 19 months (mean 9.5 months). Radiographs at the time of injuries were all malleolar fractures of pronation-external rotation (PE) stage 3 in the Lauge-Hansen classification.

Stress tests for distal tibiofibular syndesmosis were positive in all cases (dilation more than 2 mm). Arthroscopic drilling was conducted in two cases with a cartilaginous injury of trochlea of talus. Distal tibiofibular syndesmosis was anatomically repositioned and was fixed with screws after bony and soft tissues within the tibiofibular syndesmosis were removed and fibular adhesion was dissected. Ipsilateral autologous gracilis tendon was passed through foramen in the insertion of the anterior inferior tibiofibular tendon on tibia and fibula, and was fixated using the IFA system.

The preoperative Japanese society for surgery of the foot (JSSF) score was from 26 to 74 points (mean 43.5) and postoperative JSSF score was from 67 to 100 (mean 89.5). In a case where there was a poor outcome, five years of post injury had passed before the surgery. Although the JSSF score improved to 67 points postoperatively (from the preoperative score of 26) in this case, arthroscopic arthrodesis was conducted 5 months postoperatively due to persistent pain.

Anatomical reconstruction with autologous gracilis tendon using the IFA system showed a favorable functional prognosis overall. However, there was a case with progressive degenerated changes of injured distal tibiofibular syndesmosis due to a prolonged post-injury period resulted in a poor outcome.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VIII | Pages 40 - 40
1 Mar 2012
Takao M Nishii T Sakai T Nakamura N Yoshikawa H Sugano N
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Introduction

Lesion location and volume are critical factors to select patients with osteonecrosis for whom resurfacing arthroplasty is appropriate. However, no reliable surgical planning system which can assess relationship between necrotic lesions and the femoral component has been established. We have developed a 3D-MRI-based planning system for resurfacing arthroplasty. The purpose of the present study was to evaluate its feasibility.

Methods

The subjects included five patients with osteonecrosis of ARCO stage 3 or 4 who had undergone resurfacing THA at our institute. All patients had an MRI before surgery using 3D-SPGR sequences and fat suppression 3D-SPGR sequencea. In cases where it was difficult to distinguish bone marrow edema and reparative zone on 3D-SPGR images, fat suppression 3D-SPGR sequences were used. Simulation of resurfacing arthroplasty was performed on image analysis software where multidirectional oblique views could be reconstructed. The femoral neck axis was determined by drawing line through centers of two spheres which were fitted to the normal portion of the femoral head and the mid-portion of femoral neck. A femoral component was virtually implanted to align the femoral neck axis and match the implant center and femoral head center.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VIII | Pages 10 - 10
1 Mar 2012
Nishii T Sakai T Takao M Yoshikawa H Sugano N
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Introduction

In osteonecrosis of the femoral head (ONFH), progression of collapse is influenced by a repair reaction, especially bone resorptive activity, around the necrotic bone. Alendronate is a potent inhibitor of bone resorption by inhibiting osteoclast activity. We performed a clinical study to test if systemic alendronate treatment would prevent the development of collapse in patients with ONFH.

Methods

Thirty-three hips in 22 ONFH patients with initial ARCO Stage 1 to 3 were included. Fourteen patients (20 hips) received daily administration of oral alendronate 5mg/day (alendronate group) and 8 patients (13 hips) did not receive alendronate administration (Control group). Baseline investigations included anteroposterior and lateral plain radiographs, T1-weighted magnetic resonance imaging (MRI), and biochemical markers (urinary NTX and serum BAP). Examination of the biochemical markers were repeated at 3, 6, and 12 months, and MRI imaging was repeated at 12 months. At 3 years, clinical symptoms and findings on plain radiographs were compared between the 2 groups. Advancement of ARCO stages or increase of collapse by more than 2 mm were considered as development of collapse.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VIII | Pages 54 - 54
1 Mar 2012
Sakai T Nakamura N Iwana D Kitada M Nishii T Takao M Yoshikawa H Sugano N
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Introduction

Femoral neck fracture (FNF) is a common trauma in the elderly individuals. When the blood supply to the femoral head is impaired with a fracture event, the reduction or disruption of blood supply to the bone, hypoxia, leads to death of the bone marrow and trabecular bone, and eventual late segmental collapse. In the reparative process, osteoblasts and osteoclasts perform the important function of repairing the fracture site at the femoral neck. However, the reparative reaction including angiogenesis and osteogenesis remains unknown. In order to investigate the reparative reaction in patients with FNF, the distribution of tartrate resistant acid phosphatase (TRAP)-positive cells and expression of HIF-1 alpha, VEGF, and FGF-2 were observed in 36 hips in 35 patients.

Methods

There were 6 men and 30 women who had a mean age of 79 years (range, 58 to 94 years). There were 10 hips with Garden stage 3, and 26 hips with Garden stage 4. The mean duration from onset to the surgery was 12 days (range: 1 to 82 days). Hematoxylin eosin staining, TRAP staining, immunohistochemistry using anti HIF-1 alpha, anti VEGF, and anti FGF-2 antibodies were performed for retrieved whole femoral heads. As a control, one femoral head in a patient who underwent wide resection for metastatic acetabular tumor was used.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 448 - 449
1 Nov 2011
Nakahara I Nakamura N Miki H Takao M Sakai T Nishii T Yoshikawa H N.
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Using a larger diameter femoral head in total hip arthroplasty (THA) has advantages in terms of the increased joint stability and range of motion. And the wear resistance of highly cross-linked polyethylene (HXLPE) even combined with a larger head has already been demonstrated by in vitro studies. The purpose of this study was to compare the in vivo wear of Longevity HXLPE sockets against 32 mm and 26 mm heads at a 5-year follow-up.

From November 2000 to November 2001, 51 primary cementless THAs were performed with a 26 mm cobalt-chromium head and a Longevity HXLPE socket (Zimmer). A cohort of 32 mm cobalt-chromium heads was comprised of 51 THAs with the same prosthesis performed from December 2001 to December 2003. No significant differences between the groups were observed in gender, age, and BMI, however, polyethylene liners with 32 mm heads were significantly thinner than those with 26 mm heads. Two-dimensional linear wear was measured using PolyWare software on annual x-rays, and total head penetration rates at postoperative 5-year and steady state wear rates were calculated. In addition, periprosthetic osteolysis was evaluated.

At the 5-year follow-up, the total head penetration rates were 0.047±0.022 mm/year with 26 mm heads and 0.048±0.026 mm/year with 32 mm heads. The steady state wear rates were −0.008 mm/year with 26 mm heads and 0.001 mm/year with 32 mm heads. No significant differences were seen between the two groups (p=0.82 and p=0.24). Osteolysis was not observed around pros-theses in any hips.

At the 5-year follow-up, the wear rate of Longevity HXLPE was very low. A Longevity HXLPE socket will undergo the same level of wear whether with a 32 mm head or a 26 mm head.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 145 - 145
1 Mar 2010
Nakahara I Nakamura N Miki H Takao M Sakai T Nishii T Yoshikawa H Sugano N
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Ceramic heads and highly cross-linked polyethylene (HXLPE) as bearing surface materials have been introduced to reduce the production of polyethylene wear particles. The present study hypothesized that the wear rate of HXLPE could be further reduced when combined with a ceramic head. The purpose of this study was to compare the in vivo wear of Longevity HXLPE against cobalt-chromium and zirconia heads after a minimum 5-year follow-up.

A prospective cohort study was performed in 102 cementless total hip arthroplasties (THAs) with the Longevity HXLPE socket (Zimmer) between June 2000 and October 2001. Same prostheses were used in all cases both acetabular cups (Trilogy; Zimmer) and femoral stems (Versys Fiber Metal Taper; Zimmer). 26-mm zirconia heads (NGK) or 26-mm cobalt-chromium heads (Zimmer) were randomly used in 51 hips each. A minimum 5-year follow-up was completed for 47 hips with zirconia heads and 46 hips with cobalt-chromium heads. Two-dimensional linear wear of Longevity HXLPE was measured using computer-assisted methods (PolyWare) on annual x-rays, and total head penetration rates and steady state wear rates were calculated. In addition, periprosthetic osteolysis was evaluated.

At a mean 6-year follow-up, the total head penetration rates were 0.034±0.016 mm/year (zirconia) and 0.031±0.015 mm/year (cobalt-chromium). The steady state wear rates were −0.01 mm/year (zirconia) and −0.01 mm/year (cobalt-chromium). No significant difference was seen between the two groups (p=0.4 and p=0.91). Osteolysis was not observed around prostheses in any hips.

In conclusion, no advantage was seen for the zirconia head compared with the cobalt-chromium head in this time period.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 167 - 167
1 Mar 2010
Sugano N Nishii T Miki H Sakai T Takao M Ohzono K
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To analyze the long term results of a third generation ceramic on ceramic bearing in cementless total hip arthroplasty (THA), we reviewed the clinical and radiological results of 100 consecutive THAs performed in 86 patients (68 females, 80 hips; 18 males, 20 hips) between 1996 and 1998. The average age at operation was 55 years with a range of 26 to 73 years. The diagnoses were osteoarthritis in 83 hips, osteonecrosis in 10 hips and rheumatoid arthritis in 7 hips. The articulation was composed of a hemispherical titanium porous bead-coated cup (AnCA), a Biolox Forte alumina ceramic cup liner and a ball with a diameter of 28-mm. The modular ceramic liner was fixed directly to the metal cup without polyethylene sandwich or metal rim. A press-fit technique of 1 mm under-reaming without screws was used for cup fixation. The ceramic head was fixed to a 12/14 taper cone of a modular neck which allowed changes in neck-shaft angle, anteversion, and offset. All operations were performed via a posterolateral approach under general anesthesia. To measure the cup orientation, an ellipse was fitted to the acetabular component rim on the early postoperative AP radiographs using computer software. The average cup inclination and anteversion in the radiographic definition were 41 (range 28 to 63) and 17 (range 3 to 34) degrees, respectively. 22 cups were outside the Lewinnek safe zone. All patients were radiographically evaluated in term of implant stability at two years using Engh’s criteria. All of the acetabular components radiologically were judged to be bone-ingrown stable at two years except one cup. 98 stems were judged to be bone-ingrown stable and the remaining two stems were judged to be fibrous stable at two years. After two years, all patients except for two were followed up clinically and radiologically for at least 10 years or until revision or death. One unstable cup was revised at 2.5 years. This case had a previous Chiari’s pelvic osteotomy and insufficient press-fit of the cup was assumed to have led to loosening. One of the two fibrous stable stems was revised at six years due to aseptic loosening. One rheumatoid arthritis hip with stable bone ingrown fixation developed late infection at six years and was revised. One stable cup showed chipping of the acetabular liner at 8 years and required revision. The orientation of this cup was 55 degrees of inclination and 17 degrees of anteversion and the high inclination was thought to be related to the ceramic liner chipping. The remaining hips showed no osteolysis or loosening at the final follow-up. There were no squeaking hips. The 10-year survivorships with the endpoint of mechanical loosening or revision were 96.7% and 95.6%, respectively. We conclude that the third generation ceramic on ceramic hip bearing without polyethylene sandwich provided long term stability and eliminated periprosthetic osteolysis.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 110 - 110
1 Mar 2010
Tsuda K Miki H Kitada M Nakamura N Nishii T Sakai T Takao M Suzuki N Sugano N
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The anterior pelvic plane (APP) through the bilateral anterior superior iliac spines (ASIS) and pubic tuberosities is often used as a pelvic reference in measuring orientation of the acetabular cup in total hip arthroplasty. Apophyses such as ASIS are, however, anatomically variable among patients and APP does not always represent the functional pelvic tilt in the sagittal plane in each patient. Therefore, malposition of the cup and recurrent dislocation may occur even though the cup is placed in a safe zone when measured against APP. We analyzed dynamic pelvic tilt angle in the sagittal plane using a motion analysis system after THA and we found a case of recurrent dislocation due to an unusual APP tilt.

A 77-year-old woman underwent primary THA 3 years ago and cup re-implantation was done with the use of a 10-degree elevated liner and the head diameter was increased from 26mm to 28 mm after two anterior dislocations. However, posterior dislocation occurred 11 times after this. A second revision was performed with a 36 mm head and cup anteversion was optimized against APP. Further posterior dislocations occurred twice again. To probe the cause of recurrent dislocation, we performed motion analysis using a 6-camera VICON system and the markers were registered to the bone and implant models based on the postoperative CT images. This system visually represents four-dimensional dynamic motions that include the time sequential transitions of components and their posture. The cup had been placed in 6 degrees of radiographic anteversion against APP, and in −13 degrees of radiographic retroversion in supine (FPP), because the pelvic flexion angle in supine was 17.6 degrees. Furthermore, when standing, the pelvic flexion angle increased 10 degrees.

Malposition of the acetabular cup in THA is the most common cause of dislocation. To avoid errors in cup placement, computer navigation systems have been introduced and most of the navigation systems refer APP to establish cup orientation. There are two drawbacks in using APP as the reference. One is that apophyses such as ASIS develop variably in each patient with a resulting variability in APP tilt in the sagittal plane in supine. The other is significant changes in pelvis tilt during various activities of daily living such as standing, walking, and sitting. Therefore, even if cup orientation is acceptable when referencing APP, it can be mal-oriented in a functional position of the pelvis as in this case, which showed proper anteversion against APP but retroversion in supine, standing and sitting.

In conclusion, we found that there exists a case in which APP is not a suitable pelvic reference in determining orientation of the cup.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 178 - 178
1 Mar 2008
Nishii T Sugano N Miki H Takao M Koyama T Yoshikawa H
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Alendronate is a potent inhibitor of bone resorptive activity, and has been shown to prevent and restore periprosthetic osteolysis in experimental models. A preliminary study was conducted to examine clinical usefulness of a lendronate treatment.

Twenty-five patients (27 hips) with radiological evidence of osteolysis after cemented total hip arthroplasty were included. Of these, 14 patients (15 hips) were administered 5 mg of alendronate daily (alendronate group), and 11 patients (12 hips) did not receive alendronate treatment (control group). The subjects were followed up for 12 months, using radiological examinations and biochemical markers. The radiological analysis was evaluated blindly by 2 joint arthroplasty experts, each with more than 10 years of experience, without knowledge of alendronate administration.

In the alendronate group, average serum bone alkaline phosphatase and urinary excretion of the N-telopep-tide of type I collagen values decreased from the baseline values after administration of alendronate, to 71% and 76% of baseline at the 3-month examination, and 57% and 62% at the 1-year examination, respectively. In the control group, expansion of osteolysis was found in 5 hips (42%) and no hip showed restoration of osteolysis. In the alendronate group, expansion of osteolysiswas found in 2 hips (13%), and restoration of osteolysis was found in 5 hips (33%). There was a statistically significant difference in ratio of hips with osteolysis restoration between the 2 groups (p< 0.05). In the alendronate group, there was no significant difference in age, average linear wear rate of polyethylene, and the biochemical markers, between the hips with and without diminishment of osteolysis.

Conclusions: The present results indicate that clinicala-lendronate treatment can prevent and restore periprosthetic osteolysis, which is generally thought to require surgical intervention. These findings warrant further study of the effects of duration and dose of alendronate treatment, component materials, and component fixation methods.