Objectives. Lower limb muscle power is thought to influence outcome following
total knee replacement (TKR). Post-operative deficits in muscle
strength are commonly reported, although not explained. We hypothesised
that post-operative recovery of lower limb muscle power would be
influenced by the number of satellite cells in the quadriceps muscle at
time of surgery. . Methods. Biopsies were obtained from 29 patients undergoing
The results of 41 consecutive
We assessed the reproducibility and accuracy of four ratios used to measure patellar height, namely the Blackburne-Peel, Caton-Deschamps, Insall-Salvati and modified Insall-Salvati, before and after
We evaluated the safety and efficacy of total
knee replacement in patients receiving continuous warfarin therapy. . We identified 24 consecutive patients receiving long-term warfarin
therapy who underwent
Bone mineral density (BMD) around the femoral component has been reported to decrease after
Aims. The Advance Medial-Pivot
There has been a recent increase in interest
for non-cemented fixation in
Objective. Mortality rates reported by the National Joint Registry for England
and Wales (NJR) were higher following cemented total knee replacement
(TKR) compared with uncemented procedures. The aim of this study
is to examine and compare the effects of cemented and uncemented
TKR on the activation of selected markers of inflammation, endothelium,
and coagulation, and on the activation of selected cytokines involved
in the various aspects of the systemic response following surgery. Methods. This was a single centre, prospective, case-control study. Following
enrolment, blood samples were taken pre-operatively, and further
samples were collected at day one and day seven post-operatively.
One patient in the cemented group developed a deep-vein thrombosis
confirmed on ultrasonography and was excluded, leaving 19 patients
in this cohort (mean age 67.4, (. sd. 10.62)), and one patient
in the uncemented group developed a post-operative wound infection
and was excluded, leaving 19 patients (mean age 66.5, (. sd. 7.82)). Results. Both groups had a similar response with regards to the levels
of C-reactive protein (CRP), interleukin 6 (IL-6) and tumour necrosis
factor-alpha (TNFα). CD40 levels rose significantly on the cemented
group over day one to day seven compared with that of the uncemented
group, which occurred over the first 24 hours. The CD14/42a levels demonstrated
a statistically significant increase in the cemented group (p <
0.001 first 24 hours and p = 0.02 between days one and seven). . Conclusions. The uncemented and cemented groups demonstrated significant changes
in the various parameters measured at various time points but apart
from CD14/42a levels, there was no significant difference in the
serum markers of inflammation, coagulation and endothelial dysfunction
following cemented
In this study we present our experience with
four generations of uncemented total knee arthroplasty (TKA) from Smith
&
Nephew: Tricon M, Tricon LS, Tricon II and Profix, focusing
on the failure rates correlating with each design change. Beginning
in 1984, 380 Tricon M, 435 Tricon LS, 305 Tricon 2 and 588 Profix
were implanted by the senior author. The rate of revision for loosening
was 1.1% for the Tricon M, 1.1% for the Tricon LS, 0.5% for the
Tricon 2 with a HA coated tibial component, and 1.3% for the Profix
TKA. No loosening of the femoral component was seen with the Tricon
M, Tricon LS or Tricon 2, with no loosening seen of the tibial component
with the Profix
Restoration of neutral alignment of the leg is an important factor affecting the long-term results of
A postal questionnaire was sent to 10 000 patients more than one year after their
We have examined the relationship between the size of the flexion gap and the anterior translation of the tibia in flexion during implantation of a posterior cruciate ligament (PCL)-retaining BalanSys
We have examined the outcome of 400 consecutive patients who underwent
Objectives. This systematic review and meta-analysis was conducted to determine
the mid- to long-term clinical outcomes for a medial-pivot total
knee replacement (TKR) system. The objectives were to synthesise
available survivorship, Knee Society Scores (KSS), and reasons for
revision for this system. Methods. A systematic search was conducted of two online databases to
identify sources of survivorship, KSS, and reasons for revision.
Survivorship results were compared with values in the National Joint
Registry of England, Wales, and Northern Ireland (NJR). Results. A total of eight studies that included data for 1146 TKRs performed
in six countries satisfied the inclusion/exclusion criteria. Pooled
component survivorship estimates were 99.2% (95% CI, 97.7 to 99.7)
and 97.6% (95% CI, 95.8 to 98.6) at five and eight years, respectively.
Survivorship was similar or better when compared with rates reported
for all cemented TKRs combined in the NJR and was significantly
better than some insert types at mid-term intervals. The weighted
mean post-operative KSS was 87.9 (73.2 to 94.2), in the excellent
range. Similar cumulative revision rates and KSS were reported at
centres in the United States, Europe, and Asia. Conclusions. The subject system was associated with survivorship and KSS similar
or better than that reported for other
We carried out weight-bearing video radiological studies on 40 patients with a
In an initial randomised controlled trial (RCT)
we segregated 180 patients to one of two knee positions following total
knee replacement (TKR): six hours of knee flexion using either a
jig or knee extension. Outcome measures included post-operative
blood loss, fall in haemoglobin, blood transfusion requirements,
knee range of movement, limb swelling and functional scores. A second
RCT consisted of 420
We aimed to determine the reliability, accuracy and the clinical role of digital templating in the pre-operative work-up for
We randomised 102 knees suitable for a unicompartmental replacement to receive either a unicompartmental (UKR) or
We have developed a new tensor for