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Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_16 | Pages 54 - 54
19 Aug 2024
AlFayyadh F Neufeld ME Howard LC Masri BA Greidanus NV Garbuz D
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There remains concern with the use of constrained liners (CL) implanted at the time of acetabular cup revision in revision total hip replacement (rTHA). The aim of this study was to determine the implant survival in rTHA when a CL was implanted at the same time as acetabular cup revision.

We reviewed our institutional database to identify all consecutive rTHAs where a CL was implanted simultaneously at the time acetabular cup revision from 2001 to 2021. One-hundred and seventy-four revisions (173 patients) were included in the study. Mean follow-up of 8.7 years (range two – 21.7). The most common indications for rTHA were instability (35%), second-stage periprosthetic joint infection (26.4%), and aseptic loosening (17.2%).

Kaplan Meier Analysis was used to determine survival with all-cause re-revision and revision for cup aseptic loosening (fixation failure) as the endpoints.

A total of 32 (18.3%) patients underwent re-revision at a mean time of 2.9 years (range 0.1 – 14.1). The most common reasons for re-revision were instability (14), periprosthetic joint infection (seven), and loosening of the femoral component (four). Three (1.7%) required re-revision due to aseptic loosening of the acetabular component (fixation failure) at a mean of two years (0.1 – 5.1). Acetabular component survival free from re-revision due to aseptic loosening was 98.9% (95% CI 97.3 – 100) at five-years and 98.1% (95% CI 95.8 – 100) at 10-years. There were no acetabular component fixation failures in modern highly porous shells.

CLs implanted at the time acetabular cup revision in rTHA have a 98.1% 10-year survival free from acetabular cup aseptic loosening (fixation failure). There were no cup fixation failures in modern highly porous shells. Thus, when necessary, implanting a CL during revision of an acetabular component with stable screw fixation is safe with an extremely low risk of cup fixation failure.


The Bone & Joint Journal
Vol. 106-B, Issue 5 Supple B | Pages 112 - 117
1 May 2024
Hickie KL Neufeld ME Howard LC Greidanus NV Masri BA Garbuz DS

Aims

There are limited long-term studies reporting on outcomes of the Zimmer Modular Revision (ZMR) stem, and concerns remain regarding failure. Our primary aim was to determine long-term survival free from all-cause revision and stem-related failure for this modular revision stem in revision total hip arthroplasty (THA). Secondary aims included evaluating radiological and functional outcomes.

Methods

We retrospectively identified all patients in our institutional database who underwent revision THA using the ZMR system from January 2000 to December 2007. We included 106 patients (108 hips) with a mean follow-up of 14.5 years (2.3 to 22.3). Mean patient age was 69.2 years (37.0 to 89.4), and 51.9% were female (n = 55). Indications for index revision included aseptic loosening (73.1%), infection (16.7%), fracture (9.3%), and stem fracture (0.9%). Kaplan-Meier analysis was used to determine the all-cause and stem-related failure revision-free survival. At most recent follow-up, Oxford Hip Scores (OHS) were collected, and radiological stem stability was determined using the Engh classification.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_12 | Pages 31 - 31
1 Dec 2022
Sheridan G Clesham K Greidanus NV Masri B Garbuz D Duncan CP Howard L
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To date, the literature has not yet revealed superiority of Minimally Invasive (MI) approaches over conventional techniques. We performed a systematic review to determine whether minimally invasive approaches are superior to conventional approaches in total hip arthroplasty for (1) clinical and (2) functional outcomes. We performed a meta-analysis of level 1 evidence to determine whether (3) minimally invasive approaches are superior to conventional approaches for clinical outcomes.

All studies comparing MI approaches to conventional approaches were eligible for analysis. The PRISMA guidelines were adhered to throughout this study. Registries were searched using the following MeSH terms: ‘minimally invasive’, ‘muscle-sparing’, ‘THA’, ‘THR’, ‘hip arthroplasty’ and ‘hip replacement’. Locations searched included PubMed, the Cochrane Library, ClinicalTrials.gov, the EU clinical trials register and the International Clinical Trials Registry Platform (World Health Organisation).

Twenty studies were identified. There were 1,282 MI THAs and 1,351 conventional THAs performed.

There was no difference between MI and conventional approaches for all clinical outcomes of relevance including all-cause revision (p=0.959), aseptic revision (p=0.894), instability (p=0.894), infection (p=0.669) and periprosthetic fracture (p=0.940).

There was also no difference in functional outcome at early or intermediate follow-up between the two groups (p=0.38).

In level I studies exclusively, random-effects meta-analysis demonstrated no difference in the rate of aseptic revision (p=0.461) between both groups.

Intermuscular MI approaches are equivalent to conventional THA approaches when considering all-cause revision, aseptic revision, infection, dislocation, fracture rates and functional outcomes. Meta-analysis of level 1 evidence supports this claim.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_9 | Pages 5 - 5
1 Oct 2020
Zamora T Garbuz DS Greidanus NV Masri BA
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Introduction

Our objective is to describe early and midterm results with the use of a new knee prosthesis as an articulating spacer in planned two-stage management for infected total knee arthroplasty. As a second objective, we compared outcomes between the group with a retained first stage and those with a completed 2-stage revision.

Methods

Forty-seven patients (48 knees) from January 2012 and November 2017 underwent a 2-stage exchange with an articulating spacer with new implants was used for a chronic knee periprosthetic joint infection with a mean follow-up of 3.7 years (2–6.5 years).

The most frequently identified infecting organism was MSSA (31%), MRSA (21%) or MRSE (20%). At the first stage, a new PS femoral component and a new all-polyethylene posterior stabilized (PS) tibial component or a standard PS tibial liner were cemented with antibiotic-cement, typically 3.6 gm tobramycin and vancomycin 1.5 gm. IV antibiotics for six weeks were administered. The planned reimplantation was at 3 months, but ninetteen spacers (14 all poly tibias and 5 tibial liner) were retained for over 12 months.

Postoperative assessment included knee range of motion (ROM), quality of life (QOL) scores (SF-12, WOMAC, KOOS, Oxford, and UCLA scores), and a satisfaction scale from 0–100%.


The Bone & Joint Journal
Vol. 102-B, Issue 7 | Pages 852 - 860
1 Jul 2020
Zamora T Garbuz DS Greidanus NV Masri BA

Aims

Our objective is to describe our early and mid-term results with the use of a new simple primary knee prosthesis as an articulating spacer in planned two-stage management for infected knee arthroplasty. As a second objective, we compared outcomes between the group with a retained first stage and those with a complete two-stage revision.

Methods

We included 47 patients (48 knees) with positive criteria for infection, with a minimum two-year follow-up, in which a two-stage approach with an articulating spacer with new implants was used. Patients with infection control, and a stable and functional knee were allowed to retain the initial first-stage components. Outcomes recorded included: infection control rate, reoperations, final range of motion (ROM), and quality of life assessment (QoL) including Western Ontario and McMaster Universities osteoarthritis index, Knee Injury and Osteoarthritis Outcome Score, Oxford Knee Score, 12-Item Short-Form Health Survey questionnaire, and University of California Los Angeles (UCLA) activity score and satisfaction score. These outcomes were evaluated and compared to additional cohorts of patients with retained first-stage interventions and those with a complete two-stage revision. Mean follow-up was 3.7 years (2.0 to 6.5).


The Bone & Joint Journal
Vol. 102-B, Issue 7 Supple B | Pages 112 - 115
1 Jul 2020
Waly FJ Garbuz DS Greidanus NV Duncan CP Masri BA

Aims

The practice of overlapping surgery has been increasing in the delivery of orthopaedic surgery, aiming to provide efficient, high-quality care. However, there are concerns about the safety of this practice. The purpose of this study was to examine the safety and efficacy of a model of partially overlapping surgery that we termed ‘swing room’ in the practice of primary total hip (THA) and knee arthroplasty (TKA).

Methods

A retrospective review of prospectively collected data was carried out on patients who underwent primary THA and TKA between 2006 and 2017 in two academic centres. Cases were stratified as partially overlapping (swing room), in which the surgeon is in one operating room (OR) while the next patient is being prepared in another, or nonoverlapping surgery. The demographic details of the patients which were collected included operating time, length of stay (LOS), postoperative complications within six weeks of the procedure, unplanned hospital readmissions, and unplanned reoperations. Fisher's exact, Wilcoxon rank-sum tests, chi-squared tests, and logistic regression analysis were used for statistical analysis.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_11 | Pages 6 - 6
1 Oct 2019
Masri BA Zamora T Garbuz DS Greidanus NV
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Introduction

The number of medial unicompartmental knee replacements (UKR) performed for arthritis has increased and as such, revisions to total knee replacement (TKR) is increasing. Previous studies have investigated survivorship of UKR to TKR revision and functional outcomes compared to TKR to TKR revision, but have failed to detail the surgical considerations involved in these revisions. Our objectives are to investigate the detailed surgical considerations involved in UKR to TKR revisions.

Methods

This study is a retrospective comparative analysis of a prospectively collected database. From 2005 to 2017, 61 revisions of UKR to TKR were completed at a single center. Our inclusion criteria included: revision of UKR to TKR or TKR to TKR with minimum 1 year follow-up. Our exclusion criteria include: single component and liner revisions and revision for infection. The 61 UKR to TKR revisions were matched 2:1 with respect to age, ASA and BMI to a group of 122 TKR to TKR revisions. The following data was collected: indication for and time to revision, operative skin to skin surgical time, the use of specialized equipment (augment size/location, stem use), intraoperative and postoperative complications, re-operations and outcome scores (WOMAC, Oxford 12, SF 12, satisfaction score).


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_12 | Pages 20 - 20
1 Oct 2019
Masri BA Waly F Duncan CP Greidanus NV Garbuz DS
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Introduction

The practice of overlapping surgery has been increasing in the delivery of orthopaedic care, aiming to provide efficient, high-quality care. However, there have been concerns about the safety of this practice. The purpose of this study is to examine safety and efficacy of a model of partially overlapping surgery that we termed “the swing room” in practice in primary hip and knee arthroplasty.

Methods

A retrospective review of prospectively collected data using an administrative database was carried out on patients who underwent primary unilateral total hip and total knee arthroplasty from 2006 to 2017 at two sites of one academic center staffed by four arthroplasty surgeons. All revisions and bilateral primary procedures were excluded. Cases were stratified as overlapping or non-overlapping. Overlapping was defined when a surgeon had access to two operating rooms with two teams, and non-overlapping was defined as when a surgeon only had access to a single operating room on a particular day. Patient demographic characteristics, operating room time, procedure time, length of stay, Postoperative complications within 30 days of the procedure, unplanned hospital readmissions, unplanned reoperations, and emergency department visits were collected. The Fisher's exact Wilcoxon rank-sum test and logistic regression analysis were used for statistical analysis.


The Bone & Joint Journal
Vol. 100-B, Issue 6 | Pages 720 - 724
1 Jun 2018
Waterson HB Whitehouse MR Greidanus NV Garbuz DS Masri BA Duncan CP

Aims

Fretting and corrosion at the modular head/neck junction, known as trunnionosis, in total hip arthroplasty (THA) is a cause of adverse reaction to metal debris (ARMD). We describe the outcome of revision of metal-on-polyethylene (MoP) THA for ARMD due to trunnionosis with emphasis on the risk of major complications.

Patients and Methods

A total of 36 patients with a MoP THA who underwent revision for ARMD due to trunnionosis were identified. Three were excluded as their revision had been to another metal head. The remaining 33 were revised to a ceramic head with a titanium sleeve. We describe the presentation, revision findings, and risk of complications in these patients.


The Bone & Joint Journal
Vol. 98-B, Issue 2 | Pages 187 - 193
1 Feb 2016
Lash NJ Whitehouse MR Greidanus NV Garbuz DS Masri BA Duncan CP

Aims

We present a case series of ten metal-on-polyethylene total hip arthroplasties (MoP THAs) with delayed dislocation associated with unrecognised adverse local tissue reaction due to corrosion at the trunnion and pseudotumour formation.

Methods

The diagnosis was not suspected in nine of the ten patients (six female/four male; mean age 66 years), despite treatment in a specialist unit (mean time from index surgery to revision was 58 months, 36 to 84). It was identified at revision surgery and subsequently confirmed by histological examination of resected tissue. Pre-operative assessment and culture results ruled out infection. A variety of treatment strategies were used, including resection of the pseudotumour and efforts to avoid recurrent dislocation.


The Bone & Joint Journal
Vol. 97-B, Issue 8 | Pages 1024 - 1030
1 Aug 2015
Whitehouse MR Endo M Zachara S Nielsen TO Greidanus NV Masri BA Garbuz DS Duncan CP

Adverse reaction to wear and corrosion debris is a cause for concern in total hip arthroplasty (THA). Modular junctions are a potential source of such wear products and are associated with secondary pseudotumour formation.

We present a consecutive series of 17 patients treated at our unit for this complication following metal-on-highly cross-linked polyethylene (MoP) THA. We emphasise the risk of misdiagnosis as infection, and present the aggregate laboratory results and pathological findings in this series.

The clinical presentation was pain, swelling or instability. Solid, cystic and mixed soft-tissue lesions were noted on imaging and confirmed intra-operatively. Corrosion at the head–neck junction was noted in all cases. No bacteria were isolated on multiple pre- and intra-operative samples yet the mean erythrocyte sedimentation rate was 49 (9 to 100) and C-reactive protein 32 (0.6 to 106) and stromal polymorphonuclear cell counts were noted in nine cases.

Adverse soft–tissue reactions can occur in MoP THA owing to corrosion products released from the head–neck junction. The diagnosis should be carefully considered when investigating pain after THA. This may avoid the misdiagnosis of periprosthetic infection with an unidentified organism and mitigate the unnecessary management of these cases with complete single- or two-stage exchange.

Cite this article: Bone Joint J 2015;97-B:1024–1030.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVIII | Pages 109 - 109
1 Sep 2012
Masri BA Williams DH Greidanus NV Duncan CP Garbuz DS
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Purpose

There is a postulated association between increased serum metal ions and pseudotumour formation in patients with metal-on-metal hip replacements. The primary aim of this study was to assess the prevalence of pseudotumour in 31 asymptomatic patients with a large femoral head (LFH) metal-on-metal hip implant. This was compared to the prevalence of pseudotumour in 20 matched asymptomatic patients with a hip resurfacing (HRA) and 24 matched asymptomatic patients with a standard metal-on-polyethylene (MOP) total hip. A secondary objective was to assess possible correlation between increased serum metal ions and pseudotumour formation

Method

Ultrasound examination of the three groups was performed at a minimum follow up of two years. Serum metal ions were measured in the metal-on-metal LFH and HRA groups at a minimum of two years.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVIII | Pages 96 - 96
1 Sep 2012
Masri BA Baker RP Noordin S Greidanus NV Garbuz DS
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Purpose

The outcome following isolated liner exchange for revision knee arthroplasty, while an attractive option for its simplicity, has a mixed outcome reported in the literature. We report our experience in patients who had a minimum of two years follow-up.

Method

From our database we identified 44 cases in 41 patients who had an isolated liner exchange for a failed primary knee replacement. Twenty were female and the mean body mass index was 33 (range 20 to 49). The mean time to revision from their index procedure was 76 months (range 8 to 152). The mean age at revision was 69 years (range 45 to 90). Patients were assessed by use of validated quality of life questionnaires: Oxford-12, UCLA Activity Level, WOMAC and SF-12. Patients current scores were compared to pre-operative scores in 19 cases. Radiographs were assessed for polyethylene wear, osteolysis and alignment with respect to the mechanical axis. Intra-operative findings were compared to radiographic findings.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVIII | Pages 113 - 113
1 Sep 2012
Greidanus NV Garbuz DS Masri BA Duncan CP Gross AE Tanzer M Aziz A Anis A
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Purpose

The purpose of this study was to compare and evaluate the cost-effectiveness of the MIS Anterolateral Approach to that of the MIS Posterolateral and MIS Direct Lateral Approach.

Method

A prospective randomized control trial was designed and conducted to compare the MIS Anterolateral Approach to that of the MIS Posterolateral and MIS Direct Lateral Approach. Contemporary methods for economic evaluation were used to ascertain direct and indirect costs (in Canadian dollars) along with clinical effectiveness outcomes (SF6D and Pat5D utility measures). University and hospital ethics was obtained and patients were recruited and consented to participate in the RCT resulting in the assignment of 130 patients MIS hip arthroplasty procedures. Baseline patient demographics, comorbidity, quality of life, and utility were obtained for all patients. In-hospital costing data was obtained including operating room and patient room costs as well as medication, rehab and complications. Post-discharge costs were calculated from direct and indirect costs of medication, rehab, medical costs and complications until one year post-operatively. Clinical effectiveness measures were administered at intervals until one year post-operatively.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 587 - 587
1 Nov 2011
Masri BA Gooding CR Greidanus NV Garbuz DS
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Purpose: Between 1 and 2% of knee arthroplasties are complicated by infection with its associated patient morbidity. Two stage revision remains the gold standard with the minimum interval considered acceptable between the two stages as 6 weeks, but in some cases can be considerably longer depending on the patients’ clinical response to the first stage and intravenous antibiotics. The interval between the 2 stages is to allow eradication of the causative organism, however, this can result in considerable morbidity for the patient. Patients often have a poor range of movement, instability and considerable discomfort during this time and as a result have poor mobility. Further complications can be encountered at the time of the 2nd stage with considerable scarring of the soft tissues, in part secondary to the lack of mobilisation. Traditionally, spacers which are non-articulating have been used, however, problems of instability, scarring and bone erosion have been reported in the literature. The Prostalac knee spacer constitutes an antibiotic loaded acrylic cement body with a metal on polyethylene surface and enables the patient to undergo rehabilitation in the interval between the 2 stages and may also help maintain soft tissue planes as a result. Previous published results with a mean follow up of 48 months suggest the spacer is just as successful at eradicating infection (91%) as other techniques. The aim of this study is to review 119 patients with a minimum follow up of 5 years.

Method: The Prostalac Knee spacer has 2 components, a femoral and a tibial. Each are made of antibiotic-loaded acrylic cement with a small articulation of metal on polyethylene. The spacers are made from moulds so that a component of a suitable size and thickness could be made. This was a retrospective review of 119 consecutive patients. The inclusion criteria included all patients who had undergone a 2 stage revision with the Prostalac Knee spacer who had more than 5 years of follow up. Patients were assessed using the WOMAC, SF-12, Oxford Knee Score and the Knee Society Score.

Results: Thirteen patients (10.9%) out of a total of 119 had recurrence of infection. This gives an overall rate of control of infection of 89%. Of the 46 patients who completed the outcome score questionnaires with more than 5 years follow up, the mean WOMAC score was 65.9, Oxford Knee score was 61, SF-12 (physical component) was 35.7, SF-12 (mental component) was 54.8.

Conclusion: Although the Prostalac components include polyethylene and metal, they do not seem to have a detrimental impact on the rate of control of infection since our results were similar to those previously reported with other best practice techniques. It is our impression that the Prostalac functional spacer allows earlier pain free mobilisation, allowing the potential for earlier hospital discharge. The savings obtained from earlier hospital discharge greatly outweighing the increased cost of the Prostalac functional spacer system.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 567 - 567
1 Nov 2011
Greidanus NV Garbuz D Masri BA Gross A Tanzer M Duncan CP
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Purpose: The purpose of this study was to evaluate the clinical effectiveness and outcomes of the ‘abductor sparing’ MIS Anterolateral approach (MIS Watson Jones/G3) in comparison to the MIS Direct Lateral and MIS Posterolateral approaches in primary total hip arthroplasty.

Method: A multicentre, prospective, randomized controlled trial was designed to evaluate for the superiority of the new MIS Anterolateral approach (MIS Watson Jones/ G3). The sample size calculation was performed for alpha .05, power .90, to evaluate for effect size 0.5 in WOMAC using repeated measures analyses with baseline WOMAC as covariate. A total of 156 patients consented to participate in the trial and patients were assigned to MIS Antero-lateral approach or alternate MIS approach (MIS Direct Lateral or MIS Posterolateral). Patients were subjected to standardized anaesthetic and perioperative management protocols and were evaluated at standardized intervals to evaluate endpoints of early recovery (3 months) as well as endpoints of 12 and 24 months respectively. The primary outcome of interest was WOMAC, however secondary outcomes included SF-36, as well as parameters of health resource utilization and complications. Univariate and multivariate analyses were perfomed.

Results: Patient groups were found to be similar at baseline with regards to demographics and baseline quality of life outcomes (p> .05). Multivariate and repeated measures analyses demonstrated no superiority of the MIS Anterolateral approach on outcomes of WOMAC and other quality of life measures in comparison to MIS Direct Lateral and MIS Posterolateral approaches (p> .05). Health care resource utlization was also similar with length of stay, blood transfusion requirements and complications (p> .05).

Conclusion: Our multicentre, prospective, randomized clinical trial demonstrates that the MIS Anterolateral approach is not superior to alternate MIS surgical approaches when evaluating outcomes of quality of life, complications, and health resource utilization. Surgeons should consider these outcomes, complications, and other relevant advantages and disadvantages of select surgical approaches when deciding on a technique for use in their orthopaedic practice.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 4 - 4
1 Mar 2010
Greidanus NV Siegmeth A Rahman W Garbuz D Masri BA Duncan CP
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Purpose: The purpose of this study was to prospectively evaluate a consecutive series of patients receiving metal on metal hip resurfacing arthroplasty with regards to outcomes and complications at minimum of 2 years follow-up.

Method: A prospective evaluation of all patients receiving hip resurfacing was performed including baseline evaluation (demographics, WOMAC, SF12, Oxford Hip Score) and minimum 2 year follow-up assessment (WOMAC, SF12, Oxford Hip Score, UCLA activity score, Patient Satisfaction, Complications). No patients were lost to follow-up.

Results: 143 hips in 127 patients received metal-on-metal hip resurfacing arthroplasty. The mean age was 52 years and the primary diagnosis was osteoarthritis or avascular necrosis, Significant improvements were noticed across all baseline quality of life instruments (p< .05) with final mean WOMAC and Oxford Scores 95 (normalized 0–100). Final post-op satisfaction was mean 95 out of 100. Two patient sustained post-operative femoral neck fractures and required revision. An additional two patients required revision for ongoing hip pain. One patient sustained a sciatic nerve palsty and one additional patient required acetabular component repositioning on the same day as the index procedure. Revision procedures involved conversion of resurfacing femoral component to cementless total hip stem with large diameter metal head and preservation of acetabular component. Acetabular component survivorship is 99% and femoral component survivorship is 97% at 2 year follow-up.

Conclusion: Our short to midterm data, from an independant center, suggests excellent improvement in quality of life with high levels of patient satisfaction and postop acitivity level. Our comprehensive post-operative quality of life assessment demonstrates restoration of the hip to rival that of the normal non-arthritic hip joint. Complications unique to resurfacing arthroplasty occur and were not predictable based on pre-operative or intra-operative patient-specific features.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 535 - 535
1 Aug 2008
Kim WY Greidanus NV Masri BA Duncan CP Garbuz DS
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Revision of a failed acetabular reconstruction in total hip arthroplasty (THA) can be challenging when associated with significant bone loss. In cementless revision THA, achieving initial implant stability and maximising host bone contact is key to the success of reconstruction. Porous tantalum acetabular shells may represent an improvement from conventional porous coated uncemented cups in revision acetabular reconstruction associated with severe acetabular bone defects.

Methods: We reviewed the clinical and radiographic results of 46 acetabular revisions with Paprosky 2 and 3 acetabular bone defects done with a hemispheric, tantalum acetabular shell (Trabecular Metal Revision Shell, Zimmer, Warsaw, USA) and multiple supplementary screws for fixation.

Results: At a mean follow-up of 40 (24–51) months, one acetabular shell had been revised in a patient with a Paprosky 3B defect. Two liner revisions were performed for recurrent instability, without porous tantalum shell revision. The clinical outcome showed significant postoperative improvement in all measured sub-scales, compared with baseline pre-operative scores (mean improvement in Oxford Hip Score of 40.0, p < 0.001, in WOMAC of 36.7, p < 0.001, Physical component SF-12 of 12.3, p =0.0003, mental component of SF-12 of 6.8, p = 0.006). Radiographic evidence of osseointegration using validated criteria (Moore’s criteria) was demonstrated in 39 of the 40 hips available for radiographic analysis at a mean of 30.9 months, by two independent observers. Of the remaining six hips, five hips were lost to follow-up and one radiograph demonstrated failure of the hip reconstruction secondary to loss of fixation and superior migration of the component.

Discussion: Cementless acetabular revision with the porous tantalum acetabular shell demonstrated excellent early clinical and radiographic results in a series of complex revision acetabular reconstruction associated with severe bone defects. The evidence of radiographic osseointegration suggests that outcome should remain favourable, however, further longer-term evaluation is warranted.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 535 - 535
1 Aug 2008
Biring GS Masri BA Greidanus NV Duncan CP Garbuz DS
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Introduction: The aims of this study were to

determine predictors of pain, function and activity level 1–2 years after revision hip arthroplasty and

define quality of life outcomes after revision total hip replacement.

Methods: A prospective cohort of 222 patients who underwent revision hip arthroplasty were evaluated. Predictive models were developed and proportional odds regression analyses were performed to identify factors that predict quality of life outcomes at 1 and 2 years post surgery. The dependent outcome variables were WOMAC function, pain and UCLA activity. The independent variables included patient demographic, surgery specific and objective parameters including baseline Western Ontario McMaster Universities (WOMAC) osteoarthritis index, and the Short Form-12 mental component. The Loess method was used to plot the change of WOMAC and SF-12 scores over time.

Results: There was a significant improvement (p< 0.001) in all patient quality of life scores from baseline with results plateauing at 1 year. UCLA activity remained static between 1 and 2 years. In the predictive model, higher baseline WOMAC function (p < 0.001), age between 60–70 (p< 0.037), male gender (0.017), lower Charnley class (p < 0.001) and diagnosis of aseptic loosening (p < 0.003) were significant predictors of improved function.

When considering WOMAC pain as an outcome variable, factors predictive of improving category outcome included baseline WOMAC function (p= 0.001), age between 60–70 (p< 0.004), male gender (p= 0.005), lower Charnley class (p< 0.001) and no previous revisions (p < 0.023). Baseline WOMAC pain did not predict final pain outcome. Baseline WOMAC function (p=0.001), the indication for the operation (p=0.007), and the operating surgeon were significant predictors of UCLA activity at follow up. Peri or post-operative complications were not an adverse predictor of physical function, pain or activity.

Conclusions: Predictors of quality of life outcomes after revision hip replacement-showed that although some patient specific and surgical specific variables were important, age, gender, Charnley class and baseline WOMAC function had the most robust associations with outcomes.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 546 - 546
1 Aug 2008
Biring GS Masri BA Garbuz DS Greidanus NV Duncan CP
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Introduction: This single incision, anterolateral intermuscular approach (AL-IM) utilizes the interval between gluteus medius and tensor fascia lata. The aims of the study were to compare the quality of life, satisfaction and complications of this approach with two of the most commonly used limited incision transmuscular (TM) approaches, namely the mini-posterior (P-TM) and the mini-direct lateral (L-TM).

Methods: 199 patients receiving MIS THA surgical procedures were evaluated prospectively (63 AL-IM, 68 P-TM and 68 L-TM). The outcome variables were WOMAC function, pain, stiffness, SF-12 (physical & mental), Oxford-12, satisfaction and radiological outcome. Parametric and non-parametric analyses were performed.

Results: There were no significant differences between groups in baseline characteristics including age, sex, BMI, co-morbidity, or pre-op WOMAC, SF-12, Oxford-12 (p> .05). However, the AL-IM group was associated with superior outcomes (p< .05) in WOMAC function, WOMAC pain, global WOMAC, Oxford-12 and SF-12 physical component.

Conclusion: In the short term the AL-IM approach provides significant improvements in quality of life scores over other limited incision approaches. It provides minimal soft tissue disruption and maintains the abductor musculature and posterior soft tissue envelope, with similar complications and radiological outcomes.