Background. Deciding how to allocate scarce surgical resources is a worldwide issue. These decisions are difficult when considering procedures aimed primarily at improving functional quality of life, such as lower extremity joint replacement (LEJR) surgery, and procedures perceived as life preserving which also have impacts on physical function, such as coronary artery bypass graft (CABG) surgery. Comparing functional outcomes of these two procedures may provide further evidence to guide resource allocation decisions. Methods. We compared patient-reported functional outcomes following CABG and LEJR surgery using standardised, validated outcome metrics. A retrospective review of prospectively collected pre- and post-operative health related quality of life (SF-36) measures were conducted from 105 patients undergoing elective CABG and 105 elective LEJR surgery patients. Patients were matched based on gender and age. Results. Pre-operatively, CABG patients reported statistically superior (p< 0.05) Physical Functioning, Bodily Pain, and Physical Component summary SF-36 scores compared to LEJR patients. However, their pre-operative General Health scores were lower. Surgery resulted in improvements in SF-36 scores for all patients, with statistically significant improvements in Bodily Pain and Physical Component scores occurring in both groups. Interestingly, improvements in 8 out of 10 SF-36 index scores were greater in the LEJR group, with the exception of Vitality and the Mental Component Summary. The pre-operative pattern of statistically better Physical Functioning in the CABG group, and superior General Health scores in the LEJR group remained following surgery. Conclusion. It appears that, despite being matched for age and gender, significant pre-operative general health differences exist between CABG and LEJR patients that persist post-operatively. While surgery results in significant improvements for both groups, CABG patients enjoy greater improvement in General Health scores while LEJR patients benefit from greater improvements in Bodily Pain scores. Further research is underway, examining how these differences reflect disease-specific scores and health care resource utilisation

We investigated the role of Plasma Viscosity (PV), C-reactive protein (CRP) and Frozen Section (FS) in diagnosing prosthetic joint infection. We compared these results with microbiological diagnosis of infection of the tissue samples (three or more samples grown same organisms in culture).

53 patients, average age 67 years (37 – 89) underwent joint revision surgery. 34 patients had hip and 19 patients had knee joint revision arthroplasty, this includes single and multiple stage revision surgeries and excision arthroplasty. Nine (17%) patients had microbiologically proven joint infection. PV had sensitivity of 100%, specificity of 43% and negative predictive value of 100%. CRP had sensitivity of 89 %, specificity of 75% and negative predictive value of 97%. FS (presence of infection being more than 5 neutrophils/hpf) had sensitivity of 56% and specificity of 84%.

We recommend PV and CRP to be used in the investigation of prosthetic joint infection. If both CRP and PV are normal the chance of infection is very low (negative predictive value of 100%). In our series an elevated PV and CRP represented a 50% chance of having a joint infection. The role of frozen section does not appear to be beneficial in the diagnosis of joint

Introduction. Sheffield Children's Hospital specialises in limb lengthening for children. Soft tissue contracture and loss of range of motion at the knee and ankle are common complications. This review aims to look at therapeutic techniques used by the therapy team to manage these issues. Materials & Methods. A retrospective case review of therapy notes was performed of femoral and tibial lengthening's over the last 3 years. Included were children having long bone lengthening with an iIntramedullary nail, circular frame or mono-lateral rail. Patients excluded were any external fixators crossing the knee/ankle joints. Results. 20 tibial and 25 femoral lengthening's met the inclusion criteria. Pathologies included, complex fractures, limb deficiency, post septic necrosis and other congenital conditions leading to growth disturbance. All patients had issues with loss of motion at some point during the lengthening process. The knee and foot/ankle were equally affected. Numerous risk factors were identified across the cohort. Treatment provided included splinting, serial casting, bolt on shoes, exercise therapy, electrical muscle stimulation and passive stretching. Conclusions. Loss of motion in lower limb joints was common. Patients at higher risk were those with abnormal anatomy, larger target lengthening's, poor compliance or lack of access to local services. Therapy played a significant role in managing joint motion during treatment. However, limitations were noted. No one treatment option gave preferential outcomes, selection of treatment needed to be patient specific. Future research should look at guidelines to aid timely input and avoid secondary complications

Medial knee OA effects approximately 4.1 million people in England. Non-surgical strategies to lower knee joint loading is commonly researched in the knee OA literature as a method to alleviate pain and discomfort. Medial knee OA is much more prevalent than lateral knee OA due to the weight bearing line passing medial to the knee causing an external knee adduction moment (KAM). Numerous potential gait retraining strategies have been proposed to reduce either the first and/or the second peak KAM, including: toe-in gait, toe-out gait, lateral trunk lean and medial thrust gait. Gait retraining has been researched with little regard to the biomechanical consequences at the hip and ankle joints. This systematic review aimed to establish whether gait retraining can reduce medial knee loading as assessed by first and second peak KAMs, establish what are the biomechanical effects a reduced KAM has on other lower limb joint biomechanics and outline patient/participant reported outcomes on how easy the gait retraining style was to implement. The protocol for this systematic review was registered with PROSPERO on the 23rd January 2018 (registration ID: CRD42018085738). 13 databases were searched by one author (J.B.B). Additionally, PROSPERO was searched for ongoing or recently completed systematic reviews. Risk of bias was assessed using the Downs and Black quality index. Search: Group one consisted of keywords “walk” OR “gait”. Keywords “knee” OR “adduction moment” built up the second group. Group three consisted “osteoarthriti” OR “arthriti” OR “osteo arthriti”, OR “OA”. Group four included “hip” OR “ankle”. the searched results of each group were combined with conjunction “AND” in all fields. Out of the eight different gait retraining strategies identified, trunk lean reduced first peak KAM the most, which was evaluated in 3 studies, reducing first peak KAM by 20%-65%. There was a lack of collective pelvic, hip and/or ankle joint biomechanical variables reported across all 11 studies. Of eight gait retraining styles identified, the strategy that reduced first peak KAM the most was an increased lateral trunk lean, which was evaluated in 3 different studies. This is the first systematic review that has highlighted that there is limited evidence of the biomechanical consequences of a reduced knee joint load has on the pelvic, hip and/or ankle joints when undertaking gait retraining protocols. Future studies assessing gait retraining strategies should provide biomechanical outputs for other lower limb joints other than the knee joint, as well as providing participant perceptions on the level of difficulty the gait style is to perform

Power production in the terminal stance phase is essential for propelling the body forward during walking and is generated primarily by ankle plantarflexion. Osteoarthritis (OA) of the ankle restricts joint range of motion and is expected to reduce power production at that ankle. This loss of power may be compensated for by unaffected joints on both the ipsilateral and contralateral limbs resulting in overloading of the asymptomatic joints. Total ankle arthroplasty (TAA) has been shown to reduce pain and has the potential to restore range of motion and therefore increase ankle joint power, which could reduce overloading of the unaffected joints and increase walking speed. The purpose of this study was to test the hypothesis that ankle OA causes a loss of power in the affected ankle, compensatory power changes in unaffected lower limb joints, and that TAA will increase ankle power in the repaired ankle and reduce compensatory changes in other joints. One hundred and eighty-three patients (86 men, 97 women with average ages 64.1 and 62.4 years respectively) requiring surgical intervention for ankle OA were prospectively enrolled. Implant selection of either a fixed (INBONE or Salto Talaris) or mobile (STAR) bearing implant was based on surgeon preference. Three-dimensional kinematics and kinetics were collected prior to surgery and one year post-operatively during self-selected speed level walking using an eight-camera motion capture system and a series of force platforms. Subject walking speed and lower extremity joint power during the last third of stance at the ankle, knee, and hip were calculated bilaterally and compared before and after surgical intervention across the entire group and by implant type (fixed vs. mobile), and gender using a series of ANOVAs (JMP SAS, Cary, NC), with statistical significance defined as p < 0 .05. There were no gender differences in age, walking speed, or joint power. All patients increased walking as a result of surgery (0.87 m/s±0.26 prior to surgery and 1.13 m/s±0.24 after surgery, p < 0 .001) and increased total limb power. Normalized to total power (which accounts for changes in speed and distribution of power production across joints), prior to surgery the affected ankle contributed 19%±10% of total power while the unaffected ankle contributed 42%±12% (P < 0 .001). After surgery, the affected ankle increased to 25%±9% of total power and the unaffected ankle decreased to 38%±9% of total (P < 0.001). Other joints showed no significant power changes following surgery. Fixed bearing implants provide greater surgical ankle power improvement (61% versus 29% increase, p < 0 .002). Much of that change was due to the fact that those that received fixed-bearing implants had significantly lower walking speed and power before surgery. Ankle OA reduced ankle power production, which was partially compensated for by the unaffected ankle. TAA increases walking speed and power at the affected ankle while lowering power production on the unaffected side. The modifications in power production could lead to increased physical activity and reduced overloading of asymptomatic joints

Thromboembolic disease (TED) remains as a major concern for orthopaedic surgeons and is a well-known complication of lower extremity joint replacement procedures. While there is voluminous literature on the topic, it is difficult for the average orthopaedic surgeon to keep up with all the advancements in this area as well as the newer pharmacological options for prophylaxis. To address this, the American Academy of Orthopaedic Surgeons (AAOS) has developed a clinical practice guideline (CPG) in this area to provide treatment recommendations based on the best available evidence. Historically, guidelines for TED prophylaxis have been based largely on randomised controlled trials whose outcome measure was venographically documented deep vein thrombosis (DVT). However, many venographically documented DVTs, particularly those distal to the popliteal vein, are of no clinical consequence. Therefore, in the AAOS CPG the systematic review of the literature was focused on those outcomes that have the most clinical relevance: all-cause mortality, symptomatic or fatal pulmonary embolism (PE), proximal DVT, major bleeding and symptomatic DVT rates. Using these as the clinically important endpoints, it is evident that the extant literature is insufficient to provide definitive guidance in this area and to make specific recommendations about optimal pharmacological prophylaxis. Nonetheless, one strong recommendation has emerged from this systematic review: the guideline recommended against routine post-operative duplex ultrasonography screening of patients who undergo elective hip or knee arthroplasty. Only one risk factor – previous history of TED – had evidence demonstrating a higher risk beyond the risk from elective hip or knee arthroplasty itself (weak recommendation). There was not sufficient evidence that other potential risk factors increase the risk of TED, likely because of the relatively high background risk of elective hip or knee arthroplasty. In addition, there is very little evidence defining populations at increased risk for bleeding and bleeding-associated complications associated with pharmacological prophylaxis. However, the panel did come to a consensus that patients with known bleeding disorders or active liver disease are at an increased risk for post-operative bleeding. In these circumstances, it is recommended that mechanical compressive devices be the primary modality of prophylaxis as pharmacologic prophylaxis may increase the risk of bleeding. There was a moderate strength recommendation for the superiority of neuraxial anesthesia to limit blood loss even though there is no demonstrable effect on the incidence of TED. Finally, there was a moderate grade recommendation that pharmacologic agents (including aspirin) and/or mechanical compression devices be utilised for the prevention of VTE in patients that are undergoing elective hip or knee arthroplasty who are not at elevated risk beyond that of the surgery itself for VTE or bleeding. Clearly there is great need for better evidence with appropriately powered studies that examine the most clinically relevant outcomes in TED prophylaxis

The purpose of this study was to compare lower limb joint mechanics in patients who underwent a total knee arthroplasty (TKA) with either a posterior stabilised (PS) or with a medial pivot (MP) implant to healthy controls (CTRL) during stair ascent and descent tasks. Six PS (age: 67.2±1.5 years, BMI: 31.0±3.2 kg/m2) and 11 MP (age: 62.3±6.0 years, BMI: 29.7±3.9 kg/m2) TKA patients matched to 10 healthy CTRL participants (age: 65.6±5.5 years, BMI: 27.2±5.0 kg/m2) were included in the study. TKA patients went through 3D motion analysis after unilateral TKA with either a MP (11.7±3.4 months post-surgery) or PS (10.1±3.4 months post-surgery) implant performed using either a subvastus or medial parapatellar approach. Kinematic and kinetic data was collected using a 10-camera Vicon and two portable Kistler force plates placed on the first and second stair of a three-step staircase. Nonparametric Kruskal Wallace ANOVA tests were used and Wilcoxon rank sum tests were used to identify where significant (p < 0.05) differences occurred. When comparing both stair tasks, stair ascent showed a larger number of significant differences in kinematic and kinetic variables than stair descent. Peak knee extension was significantly (p < 0.05) greater in both TKA groups compared to the CTRL during stair descent, whereas only the PS group had significantly (p = 0.02) greater knee extension angle than the CTRL during stair ascent. The PS group had a significantly (p = 0.01) lower peak knee extension moment than the CTRL group during both tasks and compared to the MP group during stairs ascent. During stair ascent, the MP group had significantly (p = 0.02) larger peak hip extension moments than both PS and CTRL group. Greater knee extension angles in TKA groups at foot strike during stair tasks support the notion that TKA groups exhibit stiff knee during stance to reduce or avoid shear displacement on the operated knee. This could also result from many years of muscle adaptation waiting to receive a knee replacement. Reduced peak knee extension moment in the PS group during stairs tasks showed a quadriceps deficiency that could increase the risk of revision or of other joint replacement on the contralateral side or ipsilateral hip. MP group reproduced similar joint loading patterns as the CTRLs which may reduce their risk of revision. In conclusion, TKA patients continue to exhibit discrepancies from healthy knee mechanics during stair ascent and descent. Further research examining muscle function especially during stair ascent is warranted

Hip arthroplasty is commonly used as the final treatment approach for patients experiencing end-stage osteoarthritis. The number of these patients needing this treatment is expected to grow significantly by year 2030 to more than 572000 patients [Kurtz et al., 2007]. One of the important outcomes of hip arthroplasty is to improve patients' functions postoperatively. The evaluation of walking can provide a wealth of information regarding the efficiency of this treatment in improving a patient's mobility. Assessing the kinematic features of gait collected with a motion capture system combined with the aid of a motor-driven treadmill provides the advantage of enabling the evaluator to collect precise information about a large number of strides in a short period of time. Body segment kinematics (i.e. joint motion) are most often represented in the form of time series data with the abscissa (X axis) representing time and the ordinate (y axis) representing the motion of a particular joint. Although a great deal of information can be gained from the analyses of time series data, non-linear analyses tools can provide an additional and important dimension to a clinician's assessment of gait recovery. In this study eight patients (4 females, mean age 64.9, SD 11.1) have currently been assessed after unilateral hip arthroplasty. All surgeries were conducted by direct anterior approach by using two different approaches; three of the patients were treated by bone preservation technique and received Minihip short stem implant (Corin Ltd., Cirencester, UK) and five were treated by using a press fit stem implant Accolade II (Stryker, Mahwah, NJ USA). Patients performed a single three-minute trial of walking on a motor-driven treadmill at a self-selected pace. Using a 12 camera system, bilateral lower limb joint motion was collected prior to the surgery, at three and six weeks and at three and 6 months after the surgery. Depending upon the patient's preferred walking pace; between 40 and 45 strides were collected during each trial. Kinematic data obtained from force plates embedded in the treadmill were used to identify the heel strike and toe off events for each stride. After time normalizing the each of the joint angles (i.e. hip, knee, ankle) for each stride to 100 data points the data were then amplitude normalized to the initial point of the pre-surgery data. The non-linear tools of angle-angle and phase plane were used to explore relationships that are not readily apparent with linear wave form analyses. Angle-angle diagrams between a variety of joints angles both within a single limb or bilaterally enabled us to explore segmental coordination patterns and how they changed over the six months after surgery. Phase plane analyses included comparing joint motion relative to the velocity of that motion. This technique provided insights into the nature of the control of the joint. The additional information that results from the use of non-linear analyses provides an additional dimension of that can aide the clinician in understanding the recovery curve. This additional insight can be used to guide therapeutic decision making

Bleeding related wound complications including deep infection, superficial infection and haematoma cause significant morbidity in lower limb joint arthroplasty surgery. It has been observed anecdotally that patients requiring therapeutic anti-coagulation within the peri-operative period have higher rates of bleeding related complications and those requiring intravenous heparin particularly appear to do poorly. The aim of this study is to investigate the relationship between post-operative bleeding and wound complications in the patient requiring therapeutic warfarin, plus or minus heparin, in total hip arthroplasty surgery. This is a retrospective cohort study reviewing 1047 primary total hip replacements performed in a single centre over a five year period and comparing outcomes of the patients on warfarin (89) with a double-matched control group of patients not on warfarin (179). Outcomes included rates of deep infection, excessive wound ooze or haematoma, superficial infection, return to OT for washout and need for revision operation. The study group was then sub analysed comparing those on IV heparin plus oral warfarin, to those on warfarin alone. The warfarin group had significantly higher risk of deep joint infection (9% vs 2.2% p= 0.023), haematoma/wound ooze (28% vs 4% p < 0.001) and superficial infection (13.5% vs 2.2% p < 0.001) compared to the control group. In the sub analysis of the study group, those on IV heparin had significantly higher risk of haematoma/wound ooze (44% vs 28% p= 0.023) than those on warfarin alone. The requirement of therapeutic anti-coagulation in the peri-operative period is a tenuous balance between the complications of thrombo-embolic disease and bleeding-related morbidity. In the past, perhaps the full burden of bleeding related complications has not been appreciated, but now improved understanding will enable the both the surgeon and the patient to make more informed decisions regarding therapeutic anticoagulation in elective arthroplasty surgery

Introduction. Genu recurvatum is a deformity rarely seen in patients receiving total knee arthroplasty. This deformity is defined as hyperextension of the knee greater than 5°. The incidence of recurvatum has been cited in the literature as less than 1%. Purpose. The purpose of this study was to report data on 1510 consecutive total knee replacements (TKR) with navigation to demonstrate that the incidence of genu recurvatum is higher than what is cited in the literature. Methods. This is a retrospective review that was approved by our health science institutional review board. We reviewed resting, intra-operative alignment of 206 navigated total knee arthroplasty cases with recurvatum. This is data from 4 surgeons who are lower extremity joint replacement physicians. The range of motion (ROM) is measured and recorded by the attending physician during routine physical examination of the lower extremity. Demographic data was used to describe the patient group. The data will include pre-operative, intra-operative and post-operative ROM. The intra-operative data will be captured by the navigation system, this sytem is accurate to 1° and 1mm. The post-operative ROM will be obtained from an office visit. We are interested in the post-operative ROM to demonstrate correction of the recurvatum. Results. One thousand five hundred and ten primary TKR were reviewed for this study. Two hundred and six patients (13.6%) had genu recurvatum as measured by the navigation computer. The range of recurvatum was 0.5–30°; mean 5 degrees (STD 4.3°). Sixty six patients had >5 degrees of recurvatum (4.4%). Only 2 patients had recurvatum recorded on their pre-operative office visit. These 2 patients did not have extreme recurvatum, 3° and a few degrees on walking respectively. No patient had recurvatum at the 4 year visit (visit range 3 months – to 4 years). The primary diagnosis for the group was osteoarthritis, 92 %. All cases of recurvatum were treated with under resection of the femur and correction of the coronal plane. All cases were corrected intraoperatively. Conclusion. Etiology of recurvatum can be due to bony insufficiency at the anterior tibia, insufficiency at both femoral condyles or laxity of the posterior capsule and ligaments. During surgery this can be addressed by under resection of the femur and undersizing the femoral component to increase the flex space, or soft tissue tightening can be implemented. Our surgical technique aimed to balance hyperextension with reduction of the distal femoral cut. Coronal balance is also important in the management of hyperextension. Current total knee designs lack the extension cam effect and make sagital balancing critical. Recurvatum is difficult to correct after total knee arthroplasty and this issue is important to address at the time of primary surgery. The use of a navigation system helped us appreciate a deformity that is not easily detected during routine examination. This study found that genu recurvatum in patients receiving TKR is significantly higher than what is reported in the literature. This finding has important implications for the management of a small percentage but nonetheless significant number of patients. This deformity is not appreciated in the clinical setting during routine examination