Objectives. High failure rates of metal-on-metal hip arthroplasty implants have highlighted the need for more careful introduction and monitoring of new implants and for the evaluation of the safety of medical devices. The National Joint Registry and other regulatory services are unable to detect failing implants at an early enough stage. We aimed to identify validated
Aims. Bone turnover markers (BTMs) follow distinct trends after fractures and limited evidence suggests differential levels in BTMs in patients with delayed healing. The effect of vitamin D, and other factors that influence BTMs and fracture healing, is important to elucidate the use of BTMs as surrogates of fracture healing. We sought to determine whether BTMs can be used as early markers of delayed fracture healing, and the effect of vitamin D on BTM response after fracture. Methods. A total of 102 participants aged 18 to 50 years (median 28 years (interquartile range 23 to 35)), receiving an intramedullary nail for a tibial or femoral shaft fracture, were enrolled in a randomized controlled trial comparing vitamin D. 3. supplementation to placebo. Serum C-terminal telopeptide of type I collagen (CTX; bone resorption marker) and N-terminal propeptide of type I procollagen (P1NP; bone formation marker) were measured at baseline, six weeks, and 12 weeks post-injury. Clinical and radiological fracture healing was assessed at three months. Results. CTX and P1NP concentrations peaked at six weeks in all groups. Elevated six-week CTX and P1NP were associated with radiological healing at 12 weeks post-injury (odds ratio (OR) 10.5; 95% confidence interval 2.71 to 53.5, p = 0.002). We found no association between CTX or P1NP and functional healing. Baseline serum 25(OH)D showed a weak inverse relationship with P1NP (p = 0.036) and CTX (p = 0.221) at 12 weeks, but we observed no association between vitamin D supplementation and either BTM. Conclusion. Given the association between six-week BTM concentrations and three-month radiological fracture healing, CTX and P1NP appear to be potential
Introduction. The Z or “scarf” osteotomy was first described by Meyer in 1926 and then by Burutaran in 1976. It was later popularised by Weil in the USA and Barouk in Europe in the 1990's and is now an accepted technique that forms part of a surgeons' armamentarium. The theory of Diffusion of Innovations was described by Rogers in 1962 to explain how novel ideas are accepted into practice across different industries, including medicine. It has never previously been used to study the adoption of ideas in foot and ankle surgery. Methods. This paper uses publication volume as a
Aims. Knee joint distraction (KJD) is a relatively new, knee-joint
preserving procedure with the goal of delaying total knee arthroplasty
(TKA) in young and middle-aged patients. We present a randomised
controlled trial comparing the two. Patients and Methods. The 60 patients ≤ 65 years with end-stage knee osteoarthritis
were randomised to either KJD (n = 20) or TKA (n = 40). Outcomes
were assessed at baseline, three, six, nine, and 12 months. In the
KJD group, the joint space width (JSW) was radiologically assessed,
representing a
The management of displaced forearm diaphyseal fractures in adults is predominantly operative. Anatomical reduction is necessary to infer optimal motion and strength. The authors have observed an intraoperative technique where passive pronosupination is examined to assess quality of reduction as a
Introduction. Patients with asymptomatic bacteriuria (ASB) have a significantly increased risk of both superficial wound infection and deep infection following arthroplasty. Debate continues as to whether treatment of pre-operative ASB reduces the risk of subsequent prosthetic joint infection. Patients/Materials & Methods. All arthroplasty units in Scotland were contacted by telephone and asked a standard series of questions regarding pre-operative urine testing in arthroplasty patients. A review of the literature was also performed. Results. All arthroplasty units in Scotland test all patients’ urine pre-operatively. 55% of clinics dipstick urine and send a midstream urine (MSU) sample if dipstick positive. 45% send an MSU without urine dipstick testing. All treat a positive MSU with oral antibiotics via the patient's GP practice. Discussion. Historically all arthroplasty patients have had urine testing as part of their routine pre-operative assessment, and this remains current British Hip Society guidance. Globally, antibiotic use is under increasing scrutiny. The evidence for treating pre-operative ASB with antibiotics appears to be lacking but this study suggests the majority of arthroplasty units continue to test for and treat ASB. Locally, this practice has been increasingly questioned by microbiologists and general practitioners. Irrespective of antibiotic treatment, we believe identifying patients with pre-operative ASB remains useful as ASB appears to represent a
The complications of impaction bone grafting in revision hip replacement includes fracture of the femur and subsidence of the prosthesis. In this in vitro study we aimed to investigate whether the use of vibration, combined with a perforated tamp during the compaction of morsellised allograft would reduce peak loads and hoop strains in the femur as a
The most important issue in the assessment of fracture healing is to acquire information about the restoration of the mechanical integrity of bone. Many researchers have attempted to monitor stiffness either directly or indirectly for the purpose of assessing strength, as strength has been impossible to assess directly in clinical practice. The purpose of this study was thus to determine the relationship between bending stiffness and strength using mechanical testing at different times during the healing process. Unilateral, transverse, mid-tibial osteotomies with a 2-mm gap were performed in 28 rabbits. The osteotomy site was stabilized using a double-bar external fixator. The animals were divided into four groups (n=7/group/time point; 4, 6, 8 and 12 weeks). A series of images from micro-computed tomography of the gap was evaluated to detect the stage of fracture healing and a 4-point bending test was performed to measure stiffness and strength. Formation of cortex and medullary canal at the gap was seen in the 12-week group and would represent the remodeling stage. In addition, the relationship between stiffness and strength remained almost linear until at least 12 weeks. However, stiffness recovered much more rapidly than strength. Strength was not fully restored until the later stages of fracture healing. However, the current study demonstrated that stiffness could be monitored as a
The aim of this study was to examine the effects of cement in total knee arthroplasty on markers of inflammation and endothelial dysfunction, as
Introduction and Objectives: The aim of this study is to characterize cartilage perfusion and determine the degree of cartilage lesion using MRI during the injection of a paramagnetic contrast medium in pharmacokinetic models with the aim of obtaining the corresponding dynamic parameters (permeability and fraction of extracellular extravascular volume). Materials and Methods: We included 20 patients with patellar cartilage alterations in this study and proceeded to carry out their clinical assessment. The patients were randomly chosen for the glucosamine sulphate group or the placebo group. Both groups began treatment immediately after the first MR and continued uninterrupted treatment until the second exam 6 months later. Results: in patients treated with glucosamine sulphate significant differences were found between pain reported by the patients and their functional score results. There are also statistically significant differences in the Ktrans parameter, with higher values in the group that received glucosamine sulphate, both for arthritis and for chondromalacia. Discussion and Conclusions: Glucosamine sulphate has an effect on the vascular properties and metabolism of cartilage. There was a strong relationship between treatment and increased cartilage vascular permeability (Ktrans): This makes it possible for us to suggest that the measurement of capillary permeability could be a
Introduction: Local problems of metal on metal (MOM) hip arthroplasty such as pseudotumours, neck thinning and osteolysis maybe related to concentrations of cobalt and chromium ions in the synovial fluid. There is little reported on these values. Our aim was to determine the range of metal ion levels in synovial fluid, and to investigate the relationship between these samples and simultaneous blood samples. Methods: Synovial fluid and whole blood samples were taken from 30 consecutive patients at the time of revision surgery for a painful MOM hip. Aspirated fluid was not visibly contaminated with blood. Impants were in situ for a mean period of 31 months. All had normal renal function. Samples were analysed using ICP mass spectrometry and compared with 10 samples from patients without implants. Results: The mean (and range) of synovial fluid metal ion levels were 1965 ug/l (30 to 13618) and 6265 ug/l (11 to 81630) for Cobalt and Chromium respectively. There was a good correlation between synovial and blood levels for both cobalt (R=0.65, p = 0.0001) and chromium (R = 0.59, p = 0.006). Discussion and Conclusion: Metal ions in synovial fluid from MOM hips are generated from wear of the bearing surfaces, the correlation with blood metal ion levels, shown in this study, suggest that blood levels may be used as
Aim. To examine the effects of total knee arthroplasty on markers of inflammation and endothelial dysfunction, as
Topical Negative Pressure Therapy (TNPT) has gained increasing acceptance as a useful tool in wound management. Since 2002, the Royal Centre for Defence Medicine (RCDM) in South Birmingham has gained considerable experience with managing complex combat trauma with TNPT. The mainstay of managing high-energy combat wounds has changed little over the last century of conflict and remains early debridement, wound lavage, fracture stabilisation and delayed closure. Over the last 10 years the use of TNPT has proved to be a useful adjunct in promoting delayed primary and secondary closure, and is now common practise in the US and UK military medical services. There is however, little level 1 evidence to support the use of TNPT in military trauma. All military patients admitted to Selly Oak Hospital between April 2007 and March 2008 that were treated with TNPT were identified, those whose notes were available were included. 37 cases were included. There was a strong correlation between ISS, NISS, and antibiotic use during TNPT use and the total duration of secondary care. However, we found no correlation between delay to first TNPT application, the frequency or location of TNPT dressing changes and any of our
INTRODUCTION. Systemic levels of metal ions are
High short-term failure rates have been observed with a number of metal-on-metal (MoM) hip designs. Most patients require follow-up with blood metal ions, whichprovide a
Despite the recent progress, non-metastatic pediatric osteosarcomas have now a 5-year overall survival (OS) around 75% and the metastatic forms are decreasing to 20–30%. To increase these survival rates, new molecular approaches are on development to understand and highlight new candidates for targeted therapies. Tyrosine kinase receptors (TKR) are one of this target class, where new drugs were especially developped, screening now a large spectrum of TKR. After the demonstration among cancers of TKR’s clinical utility as
Tumour volume reduction (i.e. response), assessed following induction chemotherapy, has been identified as a prognostic factor for localized embryonal rhabdomyosarcoma (RME) in the CWS studies. In combination with other risk factors, it has been used to stratify secondary local and systemic treatment. It is however unclear whether the poor outcome of non-responders is due to insufficient local and/or systemic post-induction treatment. We analyzed post-induction therapy of RME-patients <
21 years with unresected localized tumours (IRS-III) and poor response (NR, i.e. <
33% tumour volume reduction) treated 1980–2005 in five consecutive CWS-trials. The NR were reviewed and subclassified (Objective Response (OR; i.e.<
33%–0%) vs. Stable Disease/Progression (PD; i.e. no reduction)). From 758 IRS-III RME-patients, 59 were NR (n=34 OR, n=25 PD). Induction for NR included dactinomycin, vincristine, alkylators ± anthracyclines in all patients. There were no significant differences in comparison of the control group and NR with regard to age, size, TN-classification, apart from site (p=0.04), and no differences regarding these parameters between OR and PD. Twenty-four NR received continued induction chemotherapy, n=32 other combinations, and n=3 no further chemotherapy following response assessment. Four patients were treated with additional high-dose chemotherapy. Fourty-two NR were irradiated with a median dose of 48Gy (control group: 45Gy). In 20 NR, the tumours were completely resected. As of 9/2008, with a median follow-up of 4.5 years (range: 0.9–12.1) for NR survivors, 34 NR are alive in CR. Reasons for the 25 deaths were: local/combined failure (n=21), systemic failure (n=1), and other reasons (n= 3). 5-yrs-OS was 71±4% for the control group, 78±15% for OR, but only 43±15% for PD (p<
0.01). Response is an important
Introduction: With the advent of harder wearing metal alloys such as cobalt chrome the technique of hip surface replacement has been resurrected. It is becoming an increasingly popular especially with the younger patient with end-stage hip arthritis. In this study we seek to demonstrate this procedure’s short term success rate for Cappagh and to demonstrate the new Joint Registry in action which has been collating data for the last 2 years. Methods: The Bluespiers online database was used to identify 200 consecutive primary hip resurfacing performed in Cappagh National Orthopaedic Hospital between January 1st 2006 and January 31st 2008. Patients completed a WOMAC 3.1 Osteoarthritis assessment and SF-36 General Health survey before their operation and at their 1st Joint Registry Clinic Review, typically between five and 9 months post-operatively. Findings: 200 hip resurfacing procedures by 7 surgeons were identified between January 1st 2006 and January 31st 2008. The mean patient age was 55 years(range, 23 to 81 years). 48 (32%) were female and 152 (68%) were male. Two post-operative femoral neck fractures were recorded which were converted to THR. We used the SF-36 score as a
INTRODUCTION. Studies have suggested that there is a reduction in head-neck-ratio (HNR) associated with MoMHRA. A reduction in HNR at operation would decrease range of movement and increase impingement risk. Impingement could lead to 20 edge loading, increasing wear. Serum ion levels of Chromium (Cr) and Cobalt (Co) are
INTRODUCTION. Although simulation studies have shown superior wear properties of metal-on-metal articulations, increased concern exists regarding the excess in-vivo wear of a small number of Metal-on-Metal-Hip-Resurfacing (MoMHRA) implants. Serum ion levels of Chromium (Cr) and Cobalt (Co) are
