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Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_8 | Pages 13 - 13
1 May 2016
Bozkurt M Tahta M Gursoy S Akkaya M
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Objective. In this study, we aim to compare total bone amount extracted in total knee arthroplasty in implant design and the bone amount extracted through intercondylar femoral notch cut. Material and Method. In this study, we implemented 10 implants on a total of 50 sawbones from 5 different total knee arthroplasty implant brands namely Nex-Gen Legacy (Zimmer, Warsaw, IN, USA), Genesis 2 PS (Smith&Nephew, Memphis, TN, USA), Vanguard (Biomet Orthopedics Inc., Warsaw, IN, USA), Sigma PS (De Puy, Johnson&Johnson, Warsaw, IN, USA), Scorpio NRG PS (Stryker Co., Kalamazoo, USA). Equal or the closest sizes of each brand on anteroposterior plane were selected, and cuts were made following standard technique(see Fig 1 and 2). Extracted bone pieces were measured in terms of volume and length on three planes, and statistically analysed. The volume of all pieces available after each femoral incision was measured according to Archimedes’ principles. Furthermore, the volume of each intercondylar femoral notch pieces was measured separately from other pieces but with the same method. The measurement of intercondylar femoral notch pieces on 3 planes (medial-lateral, anterior-posterior, superior-inferior) was made using Kanon slide gauge (Ermak Ltd, Istanbul, TR). Femoral notch incision pieces were scanned with CAD/CAM technology using three-dimensional scanner 1 SeriesTM (Dental Wings Inc, Montreal, QC, Canada), and the measurements were confirmed with DWOS CAD 4.0.1 software (Dental Wings Inc, Montreal, QC, Canada)(see figure 3a-e). The volume of 10 intercondylar femoral notch pieces performed through the set of each brand was averaged, and considered as the incision volume of that particular brand. Results. The comparison made by excluding femoral notch cuts did not produce any statistically significant difference between the amounts of bone extracted. The least volumetric value measured in extracted intercondylar femoral notch cut was obtained using Vanguard (3,6±0,4 cm3). The gradually increasing volumes were obtained from Nex-Gen (3,7±0,5 cm3), Sigma (5,7±0,4 cm3), Genesis 2 (6,3±0,3 cm3) and Scorpio NRG (6,7±0,7 cm3), respectively. There was no statistical difference between Genesis 2 and Scorpio NRG, and between Nex-Gen and Vanguard. Conclusion. There are significant differences among implant designs in terms of preserving bone stock, and much of these differences stems from intercondylar femoral notch incision


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIX | Pages 10 - 10
1 Jul 2012
Robinson JR Singh R Artz N Murray JR Porteous AJ Williams M
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Purpose. The purpose of this study was to determine whether intra-operative identification of osseous ridge anatomy (lateral intercondylar “residents” ridge and lateral bifurcate ridge) could be used to reliably define and reconstruct individuals' native femoral ACL attachments in both single-bundle (SB) and double-bundle (DB) cases. Methods. Pre-and Post-operative 3D, surface rendered, CT reconstructions of the lateral intercondylar notch were obtained for 15 patients undergoing ACL reconstruction (11 Single bundle, 4 Double-bundle or Isolated bundle augmentations). Morphology of native ACL femoral attachment was defined from ridge anatomy on the pre-operative scans. Centre's of the ACL attachment, AM and PL bundles were recorded using the Bernard grid and Amis' circle methods. During reconstruction soft tissue was carefully removed from the lateral notch wall with RF coblation to preserve and visualise osseous ridge anatomy. For SB reconstructions the femoral tunnel was sited centrally on the lateral bifurcate ridge, equidistant between the lateral intercondylar ridge and posterior cartilage margin. For DB reconstructions tunnels were located either side of the bifurcate ridge, leaving a 2mm bony bridge. Post-operative 3D CTs were obtained within 6 weeks post-op to correlate tunnel positions with pre-op native morphology. Results. Pre-op native ACL attachment site morphology was very similar to previous in-vitro studies: the mean centre was found at 27% along Blumensaat's line (range 19-33%) and 38% the width of the lateral femoral condyle (range 31-43%). Despite the variability between individuals there was close correlation between pre-operative localization of the femoral attachment centre and position of single bundle ACL reconstructions tunnels on the post-op CT (R=0.92). Similar results were observed for double-bundle and isolated bundle augment reconstructions. Conclusion. ACL attachment site morphology varies between individuals. Intra-operative localization of the osseous landmarks (lateral intercondylar and bifurcate ridges) appears to lead to accurate, individualised anatomical tunnel placement whether using single or double-bundle reconstruction techniques


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 11 | Pages 1475 - 1478
1 Nov 2011
Sonnery-Cottet B Archbold P Cucurulo T Fayard J Bortolletto J Thaunat M Prost T Chambat P

It has been suggested that an increased posterior tibial slope (PTS) and a narrow notch width index (NWI) increase the risk of anterior cruciate ligament (ACL) injury. The aim of this study was to establish why there are conflicting reports on their significance. A total of fifty patients with a ruptured ACL and 50 patients with an intact ACL were included in the study. The group with ACL rupture had a statistically significantly increased PTS (p < 0.001) and a smaller NWI (p < 0.001) than the control group. When a high PTS and/or a narrow NWI were defined as risk factors for an ACL rupture, 80% of patients had at least one risk factor present; only 24% had both factors present. In both groups the PTS was negatively correlated to the NWI (correlation coefficient = -0.28, p = 0.0052). Using a univariate model, PTS and NWI appear to be correlated to rupture of the ACL. Using a logistic regression model, the PTS (p = 0.006) and the NWI (p < 0.0001) remain significant risk factors. From these results, either a steep PTS or a narrow NWI predisposes an individual to ACL injury. Future studies should consider these factors in combination rather than in isolation.


The Bone & Joint Journal
Vol. 106-B, Issue 2 | Pages 195 - 202
1 Feb 2024
Jamshidi K Kargar Shooroki K Ammar W Mirzaei A

Aims. The epiphyseal approach to a chondroblastoma of the intercondylar notch of a child’s distal femur does not provide adequate exposure, thereby necessitating the removal of a substantial amount of unaffected bone to expose the lesion. In this study, we compared the functional outcomes, local recurrence, and surgical complications of treating a chondroblastoma of the distal femoral epiphysis by either an intercondylar or an epiphyseal approach. Methods. A total of 30 children with a chondroblastoma of the distal femur who had been treated by intraregional curettage and bone grafting were retrospectively reviewed. An intercondylar approach was used in 16 patients (group A) and an epiphyseal approach in 14 (group B). Limb function was assessed using the Musculoskeletal Tumor Society (MSTS) scoring system and Sailhan’s functional criteria. Results. At final follow-up, the mean MSTS score was 29.1 (SD 0.9) in group A and 26.7 (SD 1.5) in group B (p = 0.006). According to Sailhan’s criteria, the knee function was good and fair in 14 (87.5%) and two (12.5%) patients of group A, and eight (57.1%) and six (42.9%) patients of group B, respectively (p = 0.062). The lesion had recurred in one patient (6.2%) in group A and four patients (28.6%) in group B. Limb shortening > 1 cm was recorded in one patient (6.2%) from group A and six patients (42.8%) from group B. Joint degeneration was noted in one patient from group A and three patients from group B. Conclusion. An intercondylar approach to a chondroblastoma of the middle two-quarters of the distal femoral epiphysis results in better outcomes than a medial or lateral epiphyseal approach: specifically, better limb function, a lower rate of recurrence, and a lower rate of physeal damage and joint degeneration. Cite this article: Bone Joint J 2024;106-B(2):195–202


The Bone & Joint Journal
Vol. 101-B, Issue 9 | Pages 1058 - 1062
1 Sep 2019
van Kuijk KSR Reijman M Bierma-Zeinstra SMA Waarsing JH Meuffels DE

Aims. Little is known about the risk factors that predispose to a rupture of the posterior cruciate ligament (PCL). Identifying risk factors is the first step in trying to prevent a rupture of the PCL from occurring. The morphology of the knee in patients who rupture their PCL may differ from that of control patients. The purpose of this study was to identify any variations in bone morphology that are related to a PCL. Patients and Methods. We compared the anteroposterior (AP), lateral, and Rosenberg view radiographs of 94 patients with a ruptured PCL to a control group of 168 patients matched by age, sex, and body mass index (BMI), but with an intact PCL after a knee injury. Statistical shape modelling software was used to assess the shape of the knee and determine any difference in anatomical landmarks. Results. We found shape variants on the AP and Rosenberg view radiographs to be significantly different between patients who tore their PCL and those with an intact PCL after a knee injury. Overall, patients who ruptured their PCL have smaller intercondylar notches and smaller tibial eminences than control patients. Conclusion. This study shows that differences in the shape of the knee are associated with the presence of a PCL rupture after injury. A smaller and more sharply angled intercondylar notch and a more flattened tibial eminence are related to PCL rupture. This suggests that the morphology of the knee is a risk factor for sustaining a PCL rupture. Cite this article: Bone Joint J 2019;101-B:1058–1062


The Bone & Joint Journal
Vol. 105-B, Issue 6 | Pages 696 - 701
1 Jun 2023
Kurisunkal V Morris G Kaneuchi Y Bleibleh S James S Botchu R Jeys L Parry MC

Aims. Intra-articular (IA) tumours around the knee are treated with extra-articular (EA) resection, which is associated with poor functional outcomes. We aim to evaluate the accuracy of MRI in predicting IA involvement around the knee. Methods. We identified 63 cases of high-grade sarcomas in or around the distal femur that underwent an EA resection from a prospectively maintained database (January 1996 to April 2020). Suspicion of IA disease was noted in 52 cases, six had IA pathological fracture, two had an effusion, two had prior surgical intervention (curettage/IA intervention), and one had an osseous metastasis in the proximal tibia. To ascertain validity, two musculoskeletal radiologists (R1, R2) reviewed the preoperative imaging (MRI) of 63 consecutive cases on two occasions six weeks apart. The radiological criteria for IA disease comprised evidence of tumour extension within the suprapatellar pouch, intercondylar notch, extension along medial/lateral retinaculum, and presence of IA fracture. The radiological predictions were then confirmed with the final histopathology of the resected specimens. Results. The resection histology revealed 23 cases (36.5%) showing IA disease involvement compared with 40 cases without (62%). The intraobserver variability of R1 was 0.85 (p < 0.001) compared to R2 with κ = 0.21 (p = 0.007). The interobserver variability was κ = 0.264 (p = 0.003). Knee effusion was found to be the most sensitive indicator of IA involvement, with a sensitivity of 91.3% but specificity of only 35%. However, when combined with a pathological fracture, this rose to 97.5% and 100% when disease was visible in Hoffa’s fat pad. Conclusion. MRI imaging can sometimes overestimate IA joint involvement and needs to be correlated with clinical signs. In the light of our findings, we would recommend EA resections when imaging shows effusion combined with either disease in Hoffa’s fat pad or retinaculum, or pathological fractures. Cite this article: Bone Joint J 2023;105-B(6):696–701


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 30 - 30
1 Mar 2009
Gillies R Hogg M Donohoo S Schmidt W Racanelli J
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Introduction: Bone resorption at the bone-implant interface is still a problem, leading to pain, poor function and the possibility of bone fracture. This loss of supporting bone tissue is due to resorption and impaired bone formation. Loosening of an implant is often not clinically or radiographically apparent for 8–10 years. It would be beneficial if these potential failures could be identified early so that revision surgery can be avoided. The aim of this study was to investigate the influence of implant material property changes and its influence on the trabecular loading patterns of the underlying supporting bone structure. Methods: An intact and reconstructed 3D finite element (FE) model of a human femur was developed. The model was generated using PATRAN and CT scans. This was used to determine the stress, strain and interface sliding of a knee implant at heel-strike and stair climbing phases of gait. FE analysis of the model was performed using ABAQUS software. The materials properties of the bone were extracted from the CT data and applied using FORTRAN subroutines. Implant-bone interfaces were simulated using cementless fixation concepts. Sliding contact conditions were applied to simulate the immediate post-operative period. Results: Three material property cases were analysed, with respect to the intact bone, at 100%, 25% and 2.5% of cobalt chrome’s (CoCr) Youngs modulus. At heel-strike, for the 100% case, higher stress was found at anterior flange while lower stress dominated around the pegs and intercondylar notch. For the 25% case, lower stresses were found in the intercondylar notch and higher stresses above the pegs. For the 2.5% case, stresses resembled that of intact bone, higher stresses were found above the pegs and lower stress in the intercondylar notch. In stair-climbing, for the 100% case, lower stresses were found around the pegs and in the intercondylar notch. For the 25% case, lower stresses were found in the intercondylar notch and higher stresses in areas above the pegs. For the 2.5% case, higher stresses were found at the distal condyles and lower stresses were observed in the intercondylar notch. Discussion: The analysis presented changes in the trabecular loading and subsequently resulted in stress shielding. The general trend showed that the majority of stress shielding is occurring at the posterior flange and medial condyle while increased trabecular loading occurred at the anterior flange and lateral condyle regions. As the stiffness of the implant decreases from 100% to 25%, the differences in trabecular loading are extremely small. Both these implant material properties are very stiff in comparison to the underlying trabecular bone. However, as CoCr stiffness is decreased to 2.5% this yields a more homogenous stress distribution at the contact interfaces


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 408 - 408
1 Nov 2011
Itokawa T Kondo M Tomari K Sato M Hirakawa M Hara K Kaku N Higuma Y Noguchi T Tsumura H
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Introduction: Appropriate femoral component alignment is important for long-term survival of total knee arthroplasty (TKA). Valgus angle of femoral component is recommended as the angle between mechanical axis and anatomical axis of the femur. Intramedullary guide system is widely used for determining the valgus positioning of femoral component. Entry point of intramedullary guide is one of the key factors for determining valgus angle of femoral component. Some investigators have shown appropriate entry points of intramedullary guide, however, it is still unclear. In this study, appropriate entry point of intramedullary guide system was calculated using three-dimensional digital templating software “Athena” (Soft Cube, Osaka, Japan). Method: Forty-one knees in 34 osteoarthritis patients except valgus deformity (30 females and 4 males, mean age 75.1 years) received TKA and were simulated using “Athena” from January 2009 to March 2009. All cases were grade III or IV in Kellgren-Lawrence index. Radiograph and CT scan image were used for determination of appropriate entry point of femur using “Athena”. The anatomical axis of femur was defined as a line connecting the midpoints of femoral AP and lateral diameter, at 60 mm and 110 mm proximal to the center of intercondylar notch. Two coordinate systems were configured as representation of entry points. One was at the center of intercondylar notch defined as the point of origin in axial view of CT image and the line parallel to the clinical epicondylar axis (cTEA) defined as X-axis. Another coordinate system was the same point of origin but parallel to the line between trochlear groove and the center of intercondylar notch (AP line) defined as Y-axis. Result: In the coordinate system that defined the cTEA as the X-axis, the average of entry point was 0.3± 0.30 mm medial (range, −4.8~ 4.7mm) and 11.6 ± 0.52mm anterior (range, 3.1~ 16.5mm) to the center of intecondylar notch. In the other coordinate system that defined AP line as the Y-axis, the average of entry point was 2.6± 0.29 mm medial (range, −1.5~ 6.3mm) and 11.2±0.52 mm anterior (range, 2.8~ 16.0mm) to the center of intercondylar notch. Discussion: In this study, the appropriate entry point of intramdullary guide was slightly medial and about 11mm anterior to the center of intercondylar notch on average. However, individual entry point varied considerably in distance. These data indicates that it is important to simulate the appropriate entry point of intramedullary guide in preoperative planning


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 9 | Pages 1165 - 1171
1 Sep 2007
Gohil S Annear PO Breidahl W

Animal studies have shown that implanted anterior cruciate ligament (ACL) grafts initially undergo a process of revascularisation prior to remodelling, ultimately increasing mechanical strength. We investigated whether minimal debridement of the intercondylar notch and the residual stump of the ruptured ACL leads to earlier revascularisation in ACL reconstruction in humans. We undertook a randomised controlled clinical trial in which 49 patients underwent ACL reconstruction using autologous four-strand hamstring tendon grafts. Randomised by the use of sealed envelopes, 25 patients had a conventional clearance of the intercondylar notch and 24 had a minimal debridement method. Three patients were excluded from the study. All patients underwent MR scanning postoperatively at 2, 6 and 12 months, together with clinical assessment using a KT-1000 arthrometer and International Knee Documentation Committee (IKDC) evaluation. All observations were made by investigators blinded to the surgical technique. Signal intensity was measured in 4 mm diameter regions of interest along the ACL graft and the mid-substance of the posterior cruciate ligament. Our results indicate that minimal debridement leads to earlier revascularisation within the mid-substance of the ACL graft at two months (paired t-test, p = 0.002). There was a significant reduction of mid-substance signal six months after the minimal debridement technique (paired t-test, p = 0.00007). No statistically significant differences were found in tunnel placement, incidence of Cyclops lesions, blood loss, IKDC scores, range of movement or Lachman test between the two groups


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 105 - 105
1 Jun 2018
Haas S
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Patellofemoral complaints are the common and nagging problem after total knee arthroplasty. Crepitus occurs in 5% to over 20% of knee arthroplasty procedures depending on the type of implant chosen. It is caused by periarticular scar formation with microscopic and gross findings indicating inflammatory fibrous hyperplasia. Crepitus if often asymptomatic and not painful, but in some cases can cause pain. Patella “Clunk Syndrome” is less common and represents when the peripatella scarring is abundant and forms a nodule which impinges and “catches” on the implant's intercondylar notch. Patella Clunk was more common with early PS designs due to short trochlear grooves with sharp transition into the intercondylar notch. Clunks are very infrequent with modern PS implants. This syndrome has been reported in CR implants as well. Thorough debridement of the synovium and scarring at the time of arthroplasty is thought to reduce the occurrence of crepitus and clunks. Larger patella with better coverage of the cut bone may also be helpful. The diagnosis can be made on history and physical exam. X-rays are also helpful to assess patella tracking. MRI or ultrasound can be used to identify and confirm the diagnosis, but this is not mandatory. Painful crepitus and clunk syndrome that fail conservative management of NSAIDS and physical therapy may require surgery. Both crepitus and clunk can be treated with arthroscopic removal of the peripatella scar. Patella maltracking should also be assessed and treated. While recurrence may occur, it is uncommon


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_8 | Pages 31 - 31
11 Apr 2023
Powell D Wu B Dietz P Bou-Akl T Ren W Markel D
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Failure of osseointegration and periprosthetic joint infection (PJI) are the two main reasons of implant failure after total joint replacement (TJR). Nanofiber (NF) implant surface coating represents an alternative local drug eluting device that improves osseointegration and decreases the risk of PJI. The purpose of this study was to investigate the therapeutic efficacies of erythromycin (EM)-loaded coaxial PLGA/PCL-PVA NF coating in a rat S. aureus-infected tibia model. NF coatings with 100mg and 1000mg EM were prepared. NF without EM was included as positive control. 56 Sprague Dawley rats were divided into 4 groups. A titanium pin (1.0-mm x 8 mm) was placed into the tibia through the intercondylar notch. S. aureus (SA) was introduced by both direct injection of 10 μl broth (1 × 10. 4. CFU) into the medullary cavity and single dip of Ti pins into a similar solution prior to insertion. Rats were sacrificed at 8 and 16 weeks after surgery. The outcome measurements include μCT based quantitative osteolysis evaluation and hard tissue histology. Results: EM-NF coating (EM100 and EM1000) reduced osteolysis at 8 and 16 weeks, compared to EM0 and negative control. The effective infection control by EM-NFs was further confirmed by hard tissue section analysis. The Bone implant contact (BIC) and bone area fraction Occupancy (BAFO) within 200 µm of the surface of the pins were used to evaluate the osseointegration and new bone formation around the implants. At 16 weeks, the bone implant contact (BIC) of EM 100 (35.08%) was higher than that of negative control (3.43%) and EM0 (0%). The bone area fraction occupancy within 200 µm (BAFO) of EM100 (0.63 mm2) was higher than that of negative control (0.390 mm2) and EM0 (0.0 mm. 2. ). The BAFO of EM100 was also higher than that of EM1000 (0.3mm. 2. ). There was much less osteolysis observed with EM100 and EM1000 NF coatings at 16 weeks, as compared to EM0 positive control, p=0.08 and p=0.1, respectively. Osseointegration and periprosthetic bone formation was enhanced by EM-NFs, especially EM100. Data from this pilot study is promising for improving implant surface fabrication strategies


The Bone & Joint Journal
Vol. 96-B, Issue 6 | Pages 737 - 742
1 Jun 2014
Eggerding V van Kuijk KSR van Meer BL Bierma-Zeinstra SMA van Arkel ERA Reijman M Waarsing JH Meuffels DE

We have investigated whether shape of the knee can predict the clinical outcome of patients after an anterior cruciate ligament rupture. We used statistical shape modelling to measure the shape of the knee joint of 182 prospectively followed patients on lateral and Rosenberg view radiographs of the knee after a rupture of the anterior cruciate ligament. Subsequently, we associated knee shape with the International Knee Documentation Committee subjective score at two years follow-up. The mean age of patients was 31 years (21 to 51), the majority were male (n = 121) and treated operatively (n = 135). We found two modes (shape variations) that were significantly associated with the subjective score at two years: one for the operatively treated group (p = 0.002) and one for the non-operatively treated group (p = 0.003). Operatively treated patients who had higher subjective scores had a smaller intercondylar notch and a smaller width of the intercondylar eminence. Non-operatively treated patients who scored higher on the subjective score had a more pyramidal intercondylar notch as opposed to one that was more dome-shaped. We conclude that the shape of the femoral notch and the intercondylar eminence is predictive of clinical outcome two years after a rupture of the anterior cruciate ligament. Cite this article: Bone Joint J 2014;96-B:737–42


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_8 | Pages 119 - 119
1 May 2014
Haas S
Full Access

Patellofemoral complaints are the common and nagging problem after Total Knee Arthroplasty. Crepitus occurs in 5% to over 20% of knee arthroplasty procedure depending on the type of implant chosen. It is caused by periarticular scar formation with microscopic and gross findings indicating inflammatory fibrous hyperplasia. Crepitus if often asymptomatic and not painful, but in some cases can cause pain. Patella “Clunk Syndrome” is less common and represents a when the peripatella scarring is abundant and forms a nodule which impinges and “catches” on the implants intercondylar notch. Patella Clunk was more common with early PS designs due to short trochlear grooves with sharp transition into the intercondylar notch. Clunks are very infrequent with modern PS implants. This Syndrome has been reported in CR implants as well. Thorough debridement of the synovium and scarring at the time of Arthroplasty is thought to reduce the occurrence of crepitus and clunks. Larger patella with better coverage of the cut bone may also be helpful. The diagnosis can be made on history and physical exam. X-rays are also helpful to assess patella tracking. MRI or ultrasound can be used to identify and confirm the diagnosis but this is not mandatory. Painful crepitus and clunk syndrome that fail conservative management of NSAIDS and physical therapy may require surgery. Both crepitus and clunk can be treated with arthroscopic removal of the peripatella scar. Patella maltracking should also be assessed and treated. While recurrence may occur it is uncommon


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 1 | Pages 62 - 67
1 Jan 2012
Aurich M Hofmann GO Mückley T Mollenhauer J Rolauffs B

We attempted to characterise the biological quality and regenerative potential of chondrocytes in osteochondritis dissecans (OCD). Dissected fragments from ten patients with OCD of the knee (mean age 27.8 years (16 to 49)) were harvested at arthroscopy. A sample of cartilage from the intercondylar notch was taken from the same joint and from the notch of ten patients with a traumatic cartilage defect (mean age 31.6 years (19 to 52)). Chondrocytes were extracted and subsequently cultured. Collagen types 1, 2, and 10 mRNA were quantified by polymerase chain reaction. Compared with the notch chondrocytes, cells from the dissecate expressed similar levels of collagen types 1 and 2 mRNA. The level of collagen type 10 message was 50 times lower after cell culture, indicating a loss of hypertrophic cells or genes. The high viability, retained capacity to differentiate and metabolic activity of the extracted cells suggests preservation of the intrinsic repair capability of these dissecates. Molecular analysis indicated a phenotypic modulation of the expanded dissecate chondrocytes towards a normal phenotype. Our findings suggest that cartilage taken from the dissecate can be reasonably used as a cell source for chondrocyte implantation procedures.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_6 | Pages 88 - 88
1 Mar 2017
Wellings P Gruczynski M
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Patellofemoral arthroplasty (PFA) has higher revision rates than total knee arthroplasty (TKA) [Van der List, 2015; Dy, 2011]. Some indications for revision include mechanical failure, patellar mal-tracking, implant malalignment, disease progression and persistent pain or stiffness [Dy, 2011; Turktas, 2015]. Implant mal-positioning can lead to decreased patient satisfaction and increased revision rates [Turktas, 2015]. Morphological variability may increase the likelihood of implant mal-positioning. This study quantifies the morphological variability of the anterior-posterior (AP) and medial-lateral (ML) aspects of the patellofemoral compartment using a database of computed tomography (CT) scans. The analysis presented here used the custom CT based program SOMA (SOMA V.4.3.3, Stryker, Mahwah, NJ). SOMA contains a large database of 3D models created from CT scans. Anatomic analysis and implant fitting tools are also integrated into SOMA to perform morphometric analyses. A coordinate system is established from the femoral head center, the intercondylar notch, and a morphological flexion axis (MFA). The MFA is created by iteratively fitting circles to the posterior condyles and creating and axis through the circles' centers. The sagittal plane is created normal to this axis and through the notch. A coronal plane is created from the femoral head center and the flexion axis. The AP measurement is taken normal to the coronal plane from the anterior cortex sulcus to the intercondylar notch (Figure 1). A 5°-flexed anterior resection is created to run-out at the anterior cortex sulcus. The ML measurement is taken normal to the sagittal plane from the most medial to the most lateral points of the anterior resection (Figure 1). The ML measurements are broken down into medial and lateral components divided by a sagittal plane through the trochlea. Means and standard deviations of the AP and ML measurements are calculated. The mean and standard deviation for the AP measurement are 24.9mm and 2.8mm, respectively. The data predicts that 99.7% of the population will have an AP measurement between 16.5mm and 33.3mm. The mean and standard deviation for the ML measurement are 54.6 mm and 5.5mm, respectively. The data predicts that 99.7% of the population will have an ML measurement between 38.1mm and 71.1mm A Pearson Correlation value of 0.134 was calculated for AP/ML indicating a very weak positive correlation between the measures. The correlation value and the large measurement ranges indicate that there is high variability between the AP and ML measurements. A scatterplot was created to graphically represent the high variability between the AP and ML width measurements (Figure 2). A Pearson Correlation value of −0.649 was calculated for the medial and lateral components of ML (Figure 3). The results of this study suggest that patellofemoral morphology is highly variable with respect to the AP and ML dimensions. This variability may impact implant fit and positioning and should be taken into consideration in the design and use of prostheses for PFA. For any figures or tables, please contact authors directly (see Info & Metrics tab above).


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 581 - 581
1 Aug 2008
Dannawi Z Khanduja V El-Zebdeh M
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Background: Arthroscopic visualisation of the postero-medial and posterolateral compartments of the knee through the intercondylar notch using the anterolateral and anteromedial portals respectively is not commonly practiced. The purpose of this study was to prospectively evaluate whether these views are useful either diagnostically, therapeutically or both in a routine knee arthroscopy. Patients and Methods: It is a prospective study of two hundred consecutive patients who underwent a routine knee arthroscopy in our unit using the standard portals following an appropriate clinical and radiological evaluation. Posteromedial and posterolateral compartment visualisation through the intercondylar notch was undertaken in all the patients. An evaluation of the ease of the technique, the usefulness of visualisation and the morbidity associated with the procedure were recorded. Results: The technique was deemed simple to perform in 91% of the patients. It was found to be more difficult in knees with degenerative joint disease. Posteromedial and posterolateral compartment visualisation was found to be useful for diagnosis or treatment in 15% and 6% of the diagnosed conditions respectively. The technique was most useful for tears of the posterior horn of the medial meniscus, most of which were not detected by visualisation from the anteromedial compartment alone. Visualisation of the compartments was deemed adequate in 98% of the patients. There was no morbidity associated with this procedure. Conclusion: We believe that visualisation of the pos-teromedial and posterolateral compartment in a routine knee arthroscopy is beneficial; and an easy and safe procedure to perform


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_6 | Pages 40 - 40
1 May 2021
Ferreira N Cornelissen A Burger M Saini A
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Introduction. The aim of this radiographic study was to define the anatomical axis joint centre distance (aJCD) and anatomical axis joint centre ratio (aJCR) of the distal femur in the coronal plane for skeletally mature individuals. Materials and Methods. A cross-sectional radiographic study was conducted to calculate the horizontal distances between the anatomical axis and the centre of the knee at the level of the intercondylar notch and the joint line. Ratios relating these points to the width of the femur were then calculated. Results. A total of 164 radiographs were included: 91 male (55.5%) and 73 female patients (44.5%) with a mean age of 44.9 ± 18.0 years, with 79 right (48.2%) and 85 left (51.8%). The intercondylar width mean was 75.4 ± 6.8mm, the median aJCD at the notch was 3.6mm (interquartile range, IQR 2.1 – 5.1), the median aJCD at the joint line was 4.7mm (IQR 3.5 – 6.3), the aJCR at the notch 45.1 ± 2.7, and the aJCR at the joint line 43.5 ± 2.7. The intercondylar width was significantly different (p<0.001) between males (79.5 ± 5.0 mm) and females (70.4 ± 5.1 mm). A significant difference between the aJCR at the notch (p=0.003) and the aJCR at the joint line (p=0.002) was observed in males and females. No differences between the aJCD at the notch or aJCD at the joint line was observed between males versus females, left versus right and those younger versus those older than 65 years. Conclusions. This is the first objective description of the anatomic axis joint centre ratio (aJCR) of the distal femur in the coronal plane. This ratio can be used to aid the planning and execution of distal femoral deformity correction, retrograde femoral nailing, and total knee arthroplasty


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 86 - 86
1 Sep 2012
Kanekasu K Hisakado H
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Introduction. Alignment and positioning of implants is important in total knee arthroplasty (TKA). Identifying the femoral hip center (FHC) without fluoroscopy or computer navigation is considered difficult. The Complete Compass system (CoCo) is a femoral extramedullary guidance system designed to identify the FHC. This apparatus provides an accurate representation of the femoral functional axis in the coronal plane without a computer navigation system. We compared postoperative implant alignment of patients undergoing total knee arthroplasty between CoCo and intraoperative computer navigation. Materials and Methods. Twenty-five consecutive TKAs using CoCo were analyzed. CoCo has a pivotal arm with a pivotal shaft arranged to extend perpendicular to the coronal plane. A marker is attached to the pivotal arm to depict a circular arc on the marking plate with rotation of the pivotal arm. The pivotal shaft is placed at the intercondylar notch of the femur. The distance from the pivotal shaft to the marker is equal to the distance from the intercondylar notch of the femur to the FHC of the patient based on preoperative measurements in the coronal plane. This apparatus has a level of the horizontal plane and the condition of the pivotal shaft is able to match neutral positions in the sagittal and axial planes. The intersection of two arcs drawn by using CoCo with the hip joint in abduction and adduction indicates the FHC position. Postoperative coronal and sagittal views radiographs were obtained. Twenty-five TKAs implanted using computer navigation were also analyzed for postoperative alignment. For two groups, targeted implant position was 90° in both planes for the femoral functional axis. Results. In the CoCo group, mean absolute difference between planned and actual femoral placement was 0.5° (standard deviation (SD), 0.7) in the coronal plane and 2.8° (SD, 1.3) in the sagittal plane. For the computer navigation group, mean difference from ideal placement for the femur was 0.6° (SD, 0.7) in the coronal plane and 2.2° (SD, 1.4) in the sagittal plane. In all comparisons, no significant differences were seen between CoCo and computer navigation. Conclusion. In this study, the Coco group achieved accurate alignment and implant positioning without computer navigation, and results were comparable to computer navigation TKA. CoCo is a simple system, and has the possibility to take the place of expensive computer navigation systems


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 158 - 158
1 Apr 2005
Lakdawala A El-Zebdeh M Ireland J
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Introduction We describe an arthroscopic technique of excising a lesion from within the posterior septum of the knee. To our knowledge this has not been described in the literature. Case History A 35-year old male taxi-driver presented with pain in the back of his right knee. Examination did not reveal any abnormality except pain on flexing the knee beyond 90-degrees. MRI showed a multiloculated ganglion in the posterior compartment of the knee. The ganglion was located within the posterior septum and successfully excised arthroscopically. 6-months postoperatively the patient is assyptomatic. Anatomy of the posterior septum The posterior septum is located between the posterior cruciate ligament (PCL) and the posterior capsule dividing the posterior cavity of the knee into seperate posteromedial and posterolateral compartments. It is triangular in shape, formed by the reflections of the synovium from the PCL. The Technique The posterior septum of the knee was approached through the intercondylar notch by the anterior portals. Slow and careful dissection was carried out in the V-shaped space between the anterior and the posterior cruciate ligaments. The synovium of the septum was resected and the space within the septum entered. The ganglion was successfully removed. There was no complication. The relatively central placement of the anterior portals is important to gain access to the posterior septum via the notch. Discussion and conclusion Intra-articular ganglion cysts are uncommon. Reported prevalence ranges from 0.2% to 1.3%. Ganglion cysts arising from the anterior and the posterior cruciate ligaments have been well described. The ganglion cyst within the posterior septum has not been reported. The anatomy of the posterior septum makes it inaccessible to routine arthroscopic examination. It has close proximity to the vascular structures. We approached the posterior septum from the anterior portals through the intercondylar notch. The ganglion was successfully excised


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XVIII | Pages 47 - 47
1 May 2012
Bottomley N McNally E Jones L Javaid M Arden N Gill H Dodd C Murray D Beard D Price A
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Introduction. Anteromedial osteoarthritis of the knee (anteromedial gonarthrosis-AMG) is a common form of knee arthritis. In a clinical setting, knee arthritis has always been assessed by plain radiography in conjunction with pain and function assessments. Whilst this is useful for surgical decision making in bone on bone arthritis, plain radiography gives no insight to the earlier stages of disease. In a recent study 82% of patients with painful arthritis had only partial thickness joint space loss on plain radiography. These patients are managed with various surgical treatments; injection, arthroscopy, osteotomy and arthroplasty with varying results. We believe these varying results are in part due to these patients being at different stages of disease, which will respond differently to different treatments. However radiography cannot delineate these stages. We describe the Magnetic Resonance Imaging (MRI) findings of this partial thickness AMG as a way of understanding these earlier stages of the disease. Method. 46 subjects with symptomatic partial thickness AMG underwent MRI assessment with dedicated 3 Tesla sequences. All joint compartments were scored for both partial and full thickness cartilage lesions, osteophytes and bone marrow lesions (BML). Both menisci were assessed for extrusion and tear. Anterior cruciate ligament (ACL) integrity was also assessed. Osteophytes were graded on a four point scale in the intercondylar notch and the lateral margins of the joint compartments. Scoring was performed by a consultant radiologist and clinical research fellow using a validated MRI atlas with consensus reached for disagreements. The results were tabulated and relationships of the interval data assessed with linear by linear Chi2 test and Pearson's Correlation. Results. All cases had medial femoral cartilage loss; 22% partial and 78% full thickness. 79% showed medial tibial loss, however in no cases was there medial tibial loss without femoral loss. 10 cases had lateral compartment partial thickness cartilage loss. Again, there was no tibial loss without femoral loss present. Increasing size of intercondylar notch osteophyte is associated with increasing ACL damage (p=0.001). Independent to this, increasing ACL damage is associated with lateral femoral condyle cartilage loss (p=0.002). Throughout the knee the incidence of BMLs increased with increasing cartilage loss (p=0.025). Only 13% of medial menisci were normal. As meniscal damage increases, so does the incidence of BMLs in the same compartment (p=0.03). Discussion. We describe the MRI findings of early AMG with partial thickness joint space loss. In all cases there was medial femoral loss, either with or without tibial loss. We believe the disease begins on the medial femoral condyle and progresses through the joint in stages. Later stages are associated with damage to the other structures in the knee, such as the meniscus and the ACL. Damage to the ACL is associated with increasing osteophytosis. This description is the first step in describing the stages of early AMG. Description of these stages is important since we believe the outcome of surgical intervention may be dependant on these and they may guide future therapy