Aims

Scapular notching is a frequently observed radiographic phenomenon in reverse shoulder arthroplasty (RSA), signifying impingement of components. The purposes of this study were to evaluate the effect of glenoid component size and glenosphere type on impingement-free range of movement (ROM) for extension and internal and external rotation in a virtual RSA model, and to determine the optimal configuration to reduce the incidence of friction-type scapular notching.

There is currently no commercially available and clinically successful treatment for scapholunate interosseous ligament rupture, the latter leading to the development of hand-wrist osteoarthritis. We have created a novel biodegradable implant which fixed the dissociated scaphoid and lunate bones and encourages regeneration of the ruptured native ligament. To determine if scaphoid and lunate kinematics in cadaveric specimens were maintained during robotic manipulation, when comparing the native wrist with intact ligament and when the implant was installed. Ten cadaveric experiments were performed with identical conditions, except for implant geometry that was personalised to the anatomy of each cadaveric specimen. Each cadaveric arm was mounted upright in a six degrees of freedom robot using k-wires drilled through the radius, ulna, and metacarpals. Infrared markers were attached to scaphoid, lunate, radius, and 3rd metacarpal. Cadaveric specimens were robotically manipulated through flexion-extension and ulnar-radial deviation by ±40° and ±30°, respectively. The cadaveric scaphoid and lunate kinematics were examined with 1) intact native ligament, 2) severed ligament, 3) and installed implant. Digital wrist models were generated from computed tomography scans and included implant geometry, orientation, and location. Motion data were filtered and aligned relative to neutral wrist in the digital models of each specimen using anatomical landmarks. Implant insertion points in the scaphoid and lunate over time were then calculated using digital models, marker data, and inverse kinematics. Root mean squared distance was compared between severed and implant configurations, relative to intact. Preliminary data from five cadaveric specimens indicate that the implant reduced distance between scaphoid and lunate compared to severed configuration for all but three trials. Preliminary results indicate our novel implant reduced scapho-lunate gap caused by ligament transection. Future analysis will reveal if the implant can achieve wrist kinematics similar to the native intact wrist

Osteosynthesis of high-energy metaphyseal proximal tibia fractures is still challenging, especially in patients with severe soft tissue injuries and/or short stature. Although the use of external fixators is the traditional treatment of choice for open comminuted fractures, patients' acceptance is low due to the high profile and therefore the physical burden of the devices. Recently, clinical case reports have shown that supercutaneous locked plating used as definite external fixation could be an efficient alternative. Therefore, the aim of this study was to evaluate the effect of implant configuration on stability and interfragmentary motions of unstable proximal tibia fractures fixed by means of externalized locked plating. Based on a right tibia CT scan of a 48 years-old male donor, a finite element model of an unstable proximal tibia fracture was developed to compare the stability of one internal and two different externalized plate fixations. A 2-cm osteotomy gap, located 5 cm distally to the articular surface and replicating an AO/OTA 41-C2.2 fracture, was virtually fixed with a medial stainless steel LISS-DF plate. Three implant configurations (IC) with different plate elevations were modelled and virtually tested biomechanically: IC-1 with 2-mm elevation (internal locked plate fixation), IC-2 with 22-mm elevation (externalized locked plate fixation with thin soft tissue simulation) and IC-3 with 32-mm elevation (externalized locked plate fixation with thick soft tissue simulation). Axial loads of 25 kg (partial weightbearing) and 80 kg (full weightbearing) were applied to the proximal tibia end and distributed at a ratio of 80%/20% on the medial/lateral condyles. A hinge joint was simulated at the distal end of the tibia. Parameters of interest were construct stiffness, as well as interfragmentary motion and longitudinal strain at the most lateral aspect of the fracture. Construct stiffness was 655 N/mm (IC-1), 197 N/mm (IC-2) and 128 N/mm (IC-3). Interfragmentary motions under partial weightbearing were 0.31 mm (IC-1), 1.09 mm (IC-2) and 1.74 mm (IC-3), whereas under full weightbearing they were 0.97 mm (IC-1), 3.50 mm (IC-2) and 5.56 mm (IC-3). The corresponding longitudinal strains at the fracture site under partial weightbearing were 1.55% (IC-1), 5.45% (IC-2) and 8.70% (IC-3). From virtual biomechanics point of view, externalized locked plating of unstable proximal tibia fractures with simulated thin and thick soft tissue environment seems to ensure favorable conditions for callus formation with longitudinal strains at the fracture site not exceeding 10%, thus providing appropriate relative stability for secondary bone healing under partial weightbearing during the early postoperative phase

Introduction. Total knee replacement (TKR) is an established and effective surgical procedure in case of advanced osteoarthritis. However, the rate of satisfied patients amounts only to about 75 %. One common cause for unsatisfied patients is the anterior knee pain, which is partially caused by an increase in patellofemoral contact force and abnormal patellar kinematics. Since the malpositioning of the tibial and the femoral component affects the interplay in the patellofemoral joint and therefore contributes to anterior knee pain, we conducted a computational study on a cruciate-retaining (CR) TKR and analysed the effect of isolated femoral and tibial component malalignments on patellofemoral dynamics during a squat motion. Methods. To analyse different implant configurations, a musculoskeletal multibody model was implemented in the software Simpack V9.7 (Simpack AG, Gilching, Germany) from the SimTK data set (Fregly et al.). The musculoskeletal model comprised relevant ligaments with nonlinear force-strain relation according to Wismans and Hill-type muscles spanning the lower extremity. The experimental data were obtained from one male subject, who received an instrumented CR TKR. Muscle forces were calculated using a variant of the computed muscle control algorithm. To enable roll-glide kinematics, both tibio- and patellofemoral joint compartments were modelled with six degrees of freedom by implementing a polygon-contact-model representing the detailed implant surfaces. Tibiofemoral contact forces were predicted and validated using data from experimental squat trials (SimTK). The validated simulation model has been used as reference configuration corresponding to the optimal surgical technique. In the following, implant configurations, i.e. numerous combinations of relative femoral and tibial component alignment were analysed: malposition of the femoral/tibial component in mediolateral (±3 mm) and anterior-posterior (±3 mm) direction. Results. Mediolateral translation/malposition of the tibial component did not show high influence on the maximal patellofemoral contact force. Regarding the mediolateral translation of the femoral component, similar tendencies were observed. However, lateralisation of the femoral component (3 mm) clearly increased the lateral patella shift and medialisation of the tibial component (3 mm) led to a slightly increased lateral patella shift. Compared to the reference model, pronounced posterior translation of the tibial and femoral component resulted in a lower patellofemoral contact force, further increasing with higher anterior translation of the components. The translation of the tibial component showed smaller influence on the patellofemoral contact force than the translation of the femoral component. Discussion. In our present study, the mediolateral malposition of the femoral and tibial component showed no major impact on patellofemoral contact force and contribution to anterior knee pain in patients with CR TKR. However, the influence of implant component positioning in anterior-posterior direction on patellofemoral contact force is evident, especially for the femoral component. Our generated musculoskeletal model can contribute to computer-assisted preclinical testing of TKR and may support clinical decision-making in preoperative planning

To date, the fixation of proximal humeral fractures with angular stable locking plates is still insufficient with mechanical failure rates of 18% to 35%. The PHILOS plate (DePuy Synthes, Switzerland) is one of the most used implants. However, this plate has not been demonstrated to be optimal; the closely symmetric plate design and the largely heterogeneous bone mineral density (BMD) distribution of the humeral head suggest that the primary implant stability may be improved by optimizing the screw orientations. Finite element (FE) analysis allows testing of various implant configurations repeatedly to find the optimal design. The aim of this study was to evaluate whether computational optimization of the orientation of the PHILOS plate locking screws using a validated FE methodology can improve the predicted primary implant stability. The FE models of nineteen low-density (humeral head BMD range: 73.5 – 139.5 mg/cm3) left proximal humeri of 10 male and 9 female elderly donors (mean ± SD age: 83 ± 8.8 years) were created from high-resolution peripheral computer tomography images (XtremeCT, Scanco Medical, Switzerland), using a previously developed and validated computational osteosynthesis framework. To simulate an unstable mal-reduced 3-part fracture (AO/OTA 11-B3.2), the samples were virtually osteotomized and fixed with the PHILOS plate, using six proximal screws (rows A, B and E) according to the surgical guide. Three physiological loading modes with forces taken from musculoskeletal models (AnyBody, AnyBody Technology A/S, Denmark) were applied. The FE analyses were performed with Abaqus/Standard (Simulia, USA). The average principal compressive strain was evaluated in cylindrical bone regions around the screw tips; since this parameter was shown to be correlated with the experimental number of cycles to screw cut-out failure (R2 = 0.90). In a parametric analysis, the orientation of each of the six proximal screws was varied by steps of 5 in a 5×5 grid, while keeping the screw head positions constant. Unfeasible configurations were discarded. 5280 simulations were performed by repeating the procedure for each sample and loading case. The best screw configuration was defined as the one achieving the largest overall reduction in peri-screw bone strain in comparison with the PHILOS plate. With the final optimized configuration, the angle of each screw could be improved, exhibiting significantly smaller average bone strain around the screw tips (range of reduction: 0.4% – 38.3%, mean ± SD: 18.49% ± 9.56%). The used simulation approach may help to improve the fixation of complex proximal humerus fractures, especially for the target populations of patients at high risk of failure

Introduction. Conventional pre-operative planning for total hip arthroplasty mostly relies on the patient radiologic anatomy for the positioning and choice of implants. This kind of planning essentially remains a static approach since dynamic aspects such as the joint kinematics are not taken into account. Hence, clinicians are not able to fully consider the evolving behavior of the prosthetic joint that may lead to implant failures. In fact, kinematics plays an important role since some movement may create conflicts within the prosthetic joint and even provoke dislocations. The goal of our study was to assess the relationship between acetabular implant positioning variations and resultant impingements and loss of joint congruence during daily activities. In order to obtain accurate hip joint kinematics for simulation, we performed an in-vivo study using optical motion capture and magnetic resonance imaging (MRI). Methods. Motion capture and MRI was carried out on 4 healthy volunteers (mean age, 28 years). Motion from the subjects was acquired during routine (stand-to-sit, lie down) and specific activities (lace the shoes while seated, pick an object on the floor while seated or standing) known to be prone to implant dislocation and impingement. The hip joint kinematics was computed from the recorded markers trajectories using a validated optimized fitting algorithm (accuracy: translational error ≍ 0.5 mm, rotational error < 3°) which accounted for skin motion artifactsand patient-specific anatomical constraints (e.g. bone geometry reconstructed from MRI, hip joint center) (Fig. 1). 3D models of prosthetic hip joints (pelvis, proximal femur, cup, stem, head) were developed based on variations of acetabular cup's inclination (40°, 45°, 60°) and anteversion (0°, 15°, 30°) parameters, resulting in a total of 9 different implant configurations. Femoral anteversion remained fixed and determined as “neutral” with the stem being parallel to the posterior cortex of the femoral neck. Motion capture data of daily tasks were applied to all implant configurations. While visualizing the prosthetic models in motion, a collision detection algorithm was used to locate abnormal contacts between both bony and prosthetic components (Fig. 2). Moreover, femoral head translations (subluxation) were computed to evaluate the joint congruence. Results. Simulations showed collisions occurring at maximal ranges of motion in the anterosuperior part of the acetabulum. Both prosthetic and bony impingements were observed, especially while lacing shoes and lying down. The more the inclination and anteversion were important, the lower the frequency of impingements was noted (e.g. 23% at 40°/0°, 13% at 45°/15°, 5% at 60°/30°). Subluxations followed the same trend (e.g. 4.0 mm at 40°/0°, 1.5 mm at 45°/15°, 0.2 mm at 60°/30°). They occurred in a posterior direction as a consequence of impingements. Conclusion. Daily tasks could expose the prosthetic hip to subluxation and impingement located in anterosuperior position. This location could be explained by the high hip flexion required to execute the motions (≥ 95°). Considering the kinematics solely, increasing inclination and anteversion seems to decrease possible conflicts, but mechanical aspects (stress, wear) should also be considered in the definition of ideal cup positioning

Aims

This multicentre retrospective observational study’s aims were to investigate whether there are differences in the occurrence of radiolucent lines (RLLs) following total knee arthroplasty (TKA) between the conventional Attune baseplate and its successor, the novel Attune S+, independent from other potentially influencing factors; and whether tibial baseplate design and presence of RLLs are associated with differing risk of revision.

Few published series demonstrate the complications of flexible intramedullary nailing of unstable tibial diaphyseal fractures in children. A retrospective review of nineteen patients was performed, as well as a biomechanical analysis. Two common implant configurations were compared, double or divergent C and medial C and S. Five patients (26%) had complications. Two angular deformities (> 10°) occurred with the medial C and S. The C and S demonstrated lower range of motion than the double c. Despite it’s inferiority in biomechanical testing, the double c construct was associated with fewer complications and is the authors’ preferred technique. To summarize the complications seen with intramedullary flexible nailing of tibial diaphyseal fractures and to examine the clinical outcomes and biomechanical properties between two different fixation constructs (double C vs. C and S constructs). A retrospective review of nineteen patients was performed, as well as a biomechanical analysis of stability in torsion and compression when using two types of implant configurations in a pediatric sized synthetic tibia model. Outcome measures included union rates, residual deformity, and complications. Five patients (26%) had complications. Union occurred in all cases. None required repeat operation. Two (11%) angular deformities (> 10°) occurred with the medial C and S construct, versus none with the double C. The C and S configuration demonstrated significantly lower range of motion (32 + 4 degrees) compared to the double c configuration (71 + 20 degrees) (p< 0.03). There was no statistical difference in failure load at 5mm of gap closure between the C and S configuration (105 + 62N) and the double c configuration (40 + 42N) (p=0.2). The C and S construct was superior in biomechanical testing, however the double c construct had no angular deformities greater than ten degrees in the clinical series. Flexible intramedullary nail fixation is a straightforward technique that reliably produces good results. Despite it’s inferiority in biomechanical testing of a synthetic tibia model, the double c construct was associated with fewer complications and is the authors’ preferred technique

Aims

The surgical target for optimal implant positioning in robotic-assisted total knee arthroplasty remains the subject of ongoing discussion. One of the proposed targets is to recreate the knee’s functional behaviour as per its pre-diseased state. The aim of this study was to optimize implant positioning, starting from mechanical alignment (MA), toward restoring the pre-diseased status, including ligament strain and kinematic patterns, in a patient population.

Reverse Total shoulder arthroplasty (RTSA) has become an increasingly used solution to treat osteoarthritis and cuff tear arthropathy. Though successful there are still 10 to 65% complication rates reported for RTSA. Complication rates range over different reverse shoulder designs but a clear understanding of implant design parameters that cause complications is still lacking within the literature. In efforts to reduce complication rates (Implant fixation, range of motion, joint stiffness, and fracture) and improve clinical/functional outcomes having to do with proper muscle performance we have employed a computational approach to assess the sensitivity of muscle performance to changes in RTSA implant geometry and surgical placement. The goal of this study was to assess how changes in RTSA joint configuration affect deltoid performance. An approach was developed from previous work to predict a patient's muscle performance. This approach was automated to assess changes in muscle performance over 1521 joint configurations for an RTSA subject. Patient-specific muscle moment arms, muscle lengths, muscle velocities, and muscle parameters served as inputs into the muscle prediction scheme. We systematically varied joint center locations over 1521 different perturbations from the in vivo measured surgical placement to determine muscle normalized operating region for the anterior, lateral and posterior aspects of the deltoid muscle. The joint center was varied according to previous published work from the RTSA subject's nominal surgical position ±4 mm in the anterior/posterior direction, ±12mm in the medial/lateral direction, and −10 mm to 14 mm in the superior/inferior direction (Walker 2015 et al. Table 2). Overall muscle normalized operating length varied over 1521 different implant configurations for the RTSA subject. Ideal muscle normalized operating length variations were found to be in all the fundamental directions that the joint was varied. The anterior deltoid normalized operating length was found to be most sensitive with joint configurations changes in the anterior/posterior medial/lateral direction. It lateral deltoid normalized operating length was found to be most sensitive with joint configurations changes in the medial/lateral direction. It posterior deltoid normalized operating length was found to be most sensitive with joint configurations changes in the medial/lateral direction. Reserve actuation for all samples remained below 1 Nm. The most optimal deltoid normalized operating length was implemented by changing the joint configuration in the superior/inferior and medial/lateral directions. Current shoulder models focus on predicting muscle moment arms. Although valuable it does not allow me for active understanding of how lengthening the muscle will affect its ability to generate force. Our study provides an understanding of how muscle lengthening will affect the force generating capacity of each of the heads of the deltoid. With this information improvements can be made to the surgical placement and design of RTSA to improve functional/clinical outcomes while minimizing complications. For any figures or tables, please contact the authors directly

Aims

Optimal glenoid positioning in reverse shoulder arthroplasty (RSA) is crucial to provide impingement-free range of motion (ROM). Lateralization and inclination correction are not yet systematically used. Using planning software, we simulated the most used glenoid implant positions. The primary goal was to determine the configuration that delivers the best theoretical impingement-free ROM.

Background. Though many advantages of reverse total shoulder arthroplasty (RTSA) have been demonstrated, a variety of complications indicate there is much to learn about how RTSA modifies normal shoulder function. This study assesses how RTSA affects deltoid muscle moment arms post-surgery using a subject-specific computational model driven by in vivo kinematic data. Methods. A subject-specific 12 degree-of-freedom (DOF) musculoskeletal model was used to analyze the shoulders of 26 subjects (14 RTSA, 12 Normal). The model was modified from the work of Holzbaur et al. to directly input 6 DOF humerus and scapula kinematics obtained using fluoroscopy. Results. The moment arm of the anterior, lateral and poster aspects of the deltoid was found to be significantly different when comparing RTSA and normal cohorts. Anterior and lateral deltoid moment arms were found to be larger at initial elevation. There was large inter-subject variability within the RTSA group. Conclusion. Placement of implant components during RTSA can directly affect the geometric relationship between the humerus and scapula and the muscle moment arms in the RTSA shoulder. RTSA shoulders maintain the same anterior and posterior deltoid muscle moment arm patterns as healthy shoulders, but they show much greater inter-subject variation and larger moment arm magnitudes. These observations provide a basis for determining optimal implant configuration and surgical placement to maximize RTSA function in a patient-specific manner

Aims

The liner design is a key determinant of the constraint of a reverse total shoulder arthroplasty (rTSA). The aim of this study was to compare the degree of constraint of rTSA liners between different implant systems.

Aims

Total knee arthroplasty (TKA) with a highly congruent condylar-stabilized (CS) articulation may be advantageous due to increased stability versus cruciate-retaining (CR) designs, while mitigating the limitations of a posterior-stabilized construct. The aim was to assess ten-year implant survival and functional outcomes of a cemented single-radius TKA with a CS insert, performed without posterior cruciate ligament sacrifice.

Increased failure rates due to metallic wear particle-associated adverse local tissue reactions (ALTR) is a significant clinical problem in resurfacing and total hip arthroplasty. Histological analysis and particle characterization are important elements for understanding the biological mechanisms of the reaction and different histological subtypes may have unique needs for longitudinal clinical follow-up and complication rates after revision arthroplasty. Consecutive patients (N=285 cases) presenting with ALTR from three major hip implant classes, metal-on-metal resurfacing and total hip arthroplasty (THA) and non-metal-on-metal THA with dual modular neck were identified from our prospective Osteolysis Tissue Database and Repository and 53 cases were selected for wear particle nano-analysis. Conventional histology: Tissue samples taken from multiple regions around the hip with extensive sampling performed at macroscopic examination were examined by light microscopy. Particle analysis: Tissue samples selected after frozen section evaluation for cellularity and particle content were examined by scanning electron microscopy (SEM), backscatter scanning electron microscopy (BSEM), BSEM-energy-dispersive X-ray spectroscopy (EDS) element mapping examination, transmission electron microscopy (TEM), TEM-EDS element mapping, and X-ray diffraction spectrometry (XRD) examination. ALTR encompasses three main histological patterns: 1) macrophage predominant, 2) mixed lymphocytic and macrophagic, and 3) predominant sarcoid-like granulomas. Duration of implantation and composition of periprosthetic cellular infiltrates was significantly different among the three implant types examined. Distinct differences in the size, shape, and element composition of the metallic particulate material were detected in each implant class, with correlation of the severity of the adverse reaction with element complexity of the particles. ALTR encompasses a diverse range of histological patterns, which are reflective of both the implant configuration independent of manufacturer and clinical features such as duration of implantation. Distinct differences in the metallic particulate material can contribute to explain the histological features of the ALTR and variability of performance of the implants. ALTR exhibits different histological patterns and is dependent on the characteristics of the wear particulate material of each implant class and host immunological reaction

Reverse Total shoulder arthroplasty (RTSA) has become an increasingly used solution to treat osteoarthritis and cuff tear arthropathy. Though successful there are still 10 to 65% complication rates reported for RTSA. Complication rates range over different reverse shoulder designs but a clear understanding of implant design parameters that cause complications is still lacking within the literature. In efforts to reduce complication rates (Implant fixation, range of motion, joint stiffness, and fracture) and improve clinical/functional outcomes having to do with proper muscle performance we have employed a computational approach to assess the sensitivity of muscle performance to changes in RTSA implant geometry and surgical placement. The goal of this study was to assess how changes in RTSA joint configuration affect deltoid performance. An approach was developed from previous work to predict a patient's muscle performance. This approach was automated to assess changes in muscle performance over 1521 joint configurations for an RTSA subject. Patient-specific muscle moment arms, muscle lengths, muscle velocities, and muscle parameters served as inputs into the muscle prediction scheme. We systematically varied joint center locations over 1521 different perturbations from the in vivo measured surgical placement to determine muscle activation and normalized operating region for the anterior, lateral and posterior aspects of the deltoid muscle. The joint center was varied from the RTSA subject's nominal surgical position ±4 mm in the anterior/posterior direction, ±12mm in the medial/lateral direction, and −10 mm to 14 mm in the superior/inferior direction. Overall muscle activity varied over 1521 different implant configurations for the RTSA subject. For initial elevation the RTSA subject showed at least 25% deltoid activation sensitivity in each of the directions of joint configuration change(Figure 1). Posterior deltoid showed a maximal activation variation of 84% in the superior/inferior direction(Figure 1c). Deltoid activation variations lie primarily in the superior/inferior and anterior/posterior directions. An increasing trend was seen for the anterior, lateral and posterior deltoid outside of the discontinuity seen at 28°(Figure 1). Activation variations were compared to subject's experimental data. Reserve actuation for all samples remained below 4Nm(Figure 2). The most optimal deltoid normalized operating length was implemented by changing the joint configuration in the superior/inferior and medial/lateral directions(Figure 3). Current shoulder models utilize cadaver information in their assessment of generic muscle strength. In adding to this literature we performed a sensitivity study to assess the effects of RTSA joint configurations on deltoid muscle performance in a single patient-specific model. For this patient we were able to assess the best joint configuration to improve the patients muscle function and ideally their clinical outcome. With this information improvements can be made to the surgical placement and design of RTSA on a patient-specific basis to improve functional/clinical outcomes while minimizing complications. For any figures or tables, please contact authors directly (see Info & Metrics tab above).

Introduction. Reverse total shoulder arthroplasty (RTSA) can partially restore lost range of motion (ROM). Active motion restoration is largely a function of RTSA joint constraint, limiting impingement, and muscle recruitment; however, it may also be a function of implant design. The aim of this computational study was to examine the effects of implant design parameters, such as neck-shaft (N-S) angle and glenoid lateralization, on impingement-free global circumduction range of motion (GC-ROM). GC-ROM summarizes the characteristically complex, wide-ranging envelope of glenohumeral motion into a single quantity for ease of comparison. Methods. Nine computational models were used to investigate implant parameters. The parameters examined were N-S angles of 135°, 145°, and 155° in combination with glenoid lateralizations (0, 5, and 10 mm). Static positioning of the humerus was defined by an elevation direction angle, elevation angle, and rotation. The humerus was rotated from the neutral position (0° of rotation and elevation), and then elevated in different elevation directions until impingement was detected. Abduction occurred at an elevation direction angle of 0°, while flexion and extension occurred at elevation direction angles of 90° and −90°, respectively. Elevation direction angles ranged from −180° to 180°. Elevation ranged from 0° and 180°. Rotations ranged from −45° to 90°, where negative and positive rotations represented external and internal rotation, respectively. For each rotation angle, a plot of maximum elevation in each elevation plane was created using polar coordinates (radius = elevation, angle = elevation direction). The area enclosed by the resulting points, normalized with respect to the implant with a 145° N-S angle and 5 mm lateralization, was calculated. The sum of these areas defined the GC-ROM. Results. Figure 1 depicts the maximum ROM curves at each angle of rotation for a 145° N-S angle humeral implant with 5 mm of glenoid lateralization. Table 1 shows the normalized areas within the maximum ROM curves for each implant configuration at each angle of rotation, where 0% indicates that the corresponding angle of rotation could not be achieved without impingement. The effect of varying N-S angle (constant lateralization of 5 mm) and lateralization (constant N-S angle of 145°) is shown for 0° rotation (Figures 2A and 2B, respectively). Conclusions. In general, increasing glenoid lateralization increases GC-ROM; however, the unintuitive poor performance of all 10 mm lateralized configurations at rotations of −90° highlights the complex relationships between implant parameters and ROM. Interestingly, the 135° N-S implant had greater flexion and extension ROM, while the 155° N-S implant had greater abduction ROM, suggesting that there are trade-offs between N-S angles pertaining to the elevation direction in which maximum elevation is obtained. The results of this study highlight the need to incorporate multi-directional motion when assessing the effect of varying implant parameters on the impingement-free GC-ROM. Future studies will include the application of the presented technique to a broader range of implant and surgical parameters

Reverse Total shoulder arthroplasty (RTSA) has become an increasingly used solution to treat osteoarthritis and cuff tear arthropathy. Though successful there are still 10 to 65% complication rates reported for RTSA. Complication rates range over different reverse shoulder designs but a clear understanding of implant design parameters that cause complications is still lacking within the literature. In efforts to reduce complication rates (Implant fixation, range of motion, joint stiffness, and fracture) and improve clinical/functional outcomes having to do with proper muscle performance we have employed a computational approach to assess the sensitivity of muscle performance to changes in RTSA implant geometry and surgical placement. The goal of this study was to assess how changes in RTSA joint configuration affect deltoid performance. An approach was developed from previous work to predict a patient's muscle performance. This approach was automated to assess changes in muscle performance over 1521 joint configurations for an RTSA subject. Patient-specific muscle moment arms, muscle lengths, muscle velocities, and muscle parameters served as inputs into the muscle prediction scheme. We systematically varied joint center locations over 1521 different perturbations from the in vivo measured surgical placement to determine muscle activation and normalized operating region for the anterior, lateral and posterior aspects of the deltoid muscle. The joint center was varied from the RTSA subject's nominal surgical position ±4 mm in the anterior/posterior direction, ±12mm in the medial/lateral direction, and −10 mm to 14 mm in the superior/inferior direction. Overall muscle activity varied over 1521 different implant configurations for the RTSA subject. For initial elevation the RTSA subject showed at least 25% deltoid activation sensitivity in each of the directions of joint configuration change(Figure 1A–C). Posterior deltoid showed a maximal activation variation of 84% in the superior/inferior direction(Figure 1C). Deltoid activation variations lie primarily in the superior/inferior and anterior/posterior directions(Figure 1). An increasing trend was seen for the anterior, lateral and posterior deltoid outside of the discontinuity seen at 28°(Figur 1A–C). Activation variations were compared to subject's experimental data (Figure 1). Reserve actuation for all samples remained below 4Nm. The most optimal deltoid normalized operating length was implemented by changing the joint configuration in the superior/inferior and medial/lateral directions. Current shoulder models utilize cadaver information in their assessment of generic muscle strength. In adding to this literature we performed a sensitivity study to assess the effects of RTSA joint configurations on deltoid muscle performance. With this information improvements can be made to the surgical placement and design of RTSA to improve functional/clinical outcomes while minimizing complications

Reverse total shoulder arthroplasty (RTSA) is an increasingly common treatment for osteoarthritic shoulders with irreparable rotator cuff tears. Although very successful in alleviating pain and restoring some function, there is little objective information relating geometric changes imposed by the reverse shoulder and arm function, particularly the moment generating capacity of the shoulder muscles. Recent modeling studies of reverse shoulders have shown significant variation in deltoid muscle moment arms over a typical range of humeral offset locations in shoulders with RTSA. The goal of this study was to investigate the sensitivity of muscle moment arms as a function of varying the joint center and humeral offset in three representative RTSA subjects that spanned the anatomical range from our previous study cohort. We hypothesized there may exist a more beneficial joint implant placement, measured by muscle moment arms, compared to the actual surgical implant configuration. A 12 degree of freedom, subject-specific model was used to represent the shoulders of three patients with RTSA for whom fluoroscopic measurements of scapular and humeral kinematics during abduction had been obtained. The computer model used subject-specific in vivo abduction kinematics and systematically varied humeral offset locations over 1521 different perturbations from the surgical placement to determine moment arms for the anterior, lateral and posterior aspects of the deltoid muscle. The humeral offset was varied from its surgical position ±4 mm in the anterior/posterior direction, ±12mm in the medial/lateral direction, and −10 mm to 14 mm in the superior/inferior direction. The anterior deltoid moment arm varied up to 20 mm with humeral offset and center of rotation variations, primarily in the medial/lateral and superior/inferior directions. Similarly, the lateral deltoid moment arm demonstrated variations up to 20 mm, primarily with humeral offset changes in the medial/lateral and anterior/posterior directions. The posterior deltoid moment arm varied up to 15mm, primarily in early abduction, and was most sensitive to changes of the humeral offset in the superior/inferior direction. The goal of this study was to assess the sensitivity of the deltoid muscle moment arms as a function of joint configuration for existing RTSA subjects. High variations were found for all three deltoid components. Variation over the entire abduction arc was greatest in the anterior and lateral deltoid, while the posterior deltoid moment arm was mostly sensitive to humeral offset changes early in the abduction arc. Moment arm changes of 15–20 mm represent a significant amount of the total deltoid moment arm. This means there is an opportunity to dramatically change the deltoid moment arms through surgical placement of the joint center of rotation and humeral stem. Computational models of the shoulder may help surgeons optimize subject-specific placement of RTSA implants to provide the best possible muscle function, and assist implant designers to configure devices for the best overall performance

Reverse total shoulder arthroplasty (RTSA) is increasingly used in the United States since approval by the FDA in 2003. RTSA relieves pain and restores mobility in arthritic rotator cuff deficient shoulders. Though many advantages of RTSA have been demonstrated, there still are a variety of complications (implant loosening, shoulder impingement, infection, frozen shoulder) making apparent much still is to be learned how RTSA modifies normal shoulder function. The goal of this study was to assess how RTSA affects deltoid muscle moment generating capacity post-surgery using a subject-specific computational model driven by in vivo kinematic data. A subject-specific 12 degree-of-freedom (DOF) musculoskeletal model was used to analyze the shoulders of 27 subjects (14-RTSA, 12-Normal). The model was modified from the work of Holzbaur et al. to directly input 6 DOF humerus and scapula kinematics obtained using fluoroscopy. Model geometry was scaled according to each subject's skeletal dimensions. In vivo abduction kinematics for each subject were input to their subject-specific model and muscle moment arms for the anterior, lateral and posterior aspects of the deltoid were measured over the arc of motion. Similar patterns of muscle moment arm changes were observed for normal and RTSA shoulders. The moment arm of the anterior deltoid was positive with the arm at the side and decreased monotonically, crossing zero (the point at which the muscle fibers pass across the joint center) between 50°–60° glenohumeral abduction (Figure 1a). The average moment arm of the lateral deltoid was constant and positive in normal shoulders, but showed a decreasing trend with abduction in RTSA shoulders (Figure 1b). The posterior deltoid moment arm was negative with the arm at the side, and increased monotonically to a positive value with increasing glenohumeral abduction (Figure 1c). Subject-specific moment arm values for RTSA shoulders were highly variable compared to normal shoulders. 2-way repeated measures ANOVA showed significant differences between RTSA and normal shoulders for all three aspects of the deltoid moment arm, where the moment arms in RTSA shoulders were smaller in magnitude. Shoulder functional capacity is a product of the moment generating ability of the shoulder muscles which, in turn, are a function of the muscle moment arms and muscle forces. Placement of implant components during RTSA can directly affect the geometric relationship between the humerus and scapula and, therefore, the muscle moment arms in the RTSA shoulder. Our results show RTSA shoulders maintain the same muscle moment arm patterns as healthy shoulders, but they show much greater inter-subject variation and smaller moment arm magnitudes. These observations show directly how RTSA configuration and implant placement affect deltoid moment arms, and provide an objective basis for determining optimal implant configuration and surgical placement to maximize RTSA function in a patient-specific manner