The radiographic analysis of over 5000 metal on metal (MoM) hips using Ein Bild Roentgen Analyse (EBRA) software have been recently published in an attempt to determine the influence of cup orientation on bearing function. The validation of this software relies one study, conducted in a phantom pelvis without a femoral head in situ. Three dimensional computed tomographic (3D-CT) has been shown to be more accurate for hip and knee arthroplasty than plain radiographs for measurements of component orientation and position. The accuracy of EBRA when compared to 3D-CT for MoM hips specifically is unclear. We measured the cup orientation of 96 large diameter MoM hips using EBRA analysis of plain radiographs and compared this to 3D-CT. All measurements were made using the radiographic definition of cup orientation. The mean difference in version between the two imaging modalities was 8°; with wide limits of agreement of −21.2° and +5.6°. Three retroverted cups were not detected by EBRA. The mean difference in inclination values was 0.3°, but there was up to 9°difference between imaging modalities. When measured by 3D CT, 64% of hips were within a 10° safe zone around 45° inclination and 20° version, compared to only 24% when measured by EBRA (Fishers Exact test, p< 0.0001). The measurement of cup orientation of MoM hips using EBRA software is insufficiently accurate, particularly for the assessment of cup version. The cup rim is obscured by the large diameter femoral head on plain radiographs. Research studies using EBRA analysis for version have limited value if accuracy of more than 20 degrees is required to draw conclusions. This software may not be suitable to measure the performance of a device or surgeon. The limitations of EBRA can be overcome, if 3D-CT with an extended Hounsfield scale for data capture is used

This study aimed to compare the early clinical results and stem subsidence between three consecutive series of revision hip replacement cases with femoral impaction bone grafting to evaluate the effects of developments in technique. In the original series 1 (n=23), bone graft was irradiated at 25kG. I n series 2 (n=12) non-irradiated double washed graft and long stems were used as required. In series 3 (n=21) modular tamps were used. Sensitive radiographic analysis techniques, EBRA and RSA, were used to measure stem subsidence. Major stem re-revision was required in five hips in series one, one hip in series two and no hips in series three. Two periprosthetic fractures occurred in series one. There was a statistically significant reduction in stem subsidence at the cement-bone interface at 12 months between series one and series two and three (p<0.05). In series three there was negligible stem subsidence at the cement-bone interface. Technique developments in femoral impaction grafting, including the use of modular tamps designed to simply the procedure, yields excellent early clinical and radiographic results. Using RSA, we have shown that the fixation of the stems in bone is comparable to that achieved in primary hip replacement

Femoral head diameters in THA have been increasing due to good long-term outcomes of 1^st generation HXLP cups. Furthermore, some 2^nd generation HXLP cups allow 36mm or larger heads. However, larger femoral head diameters increase the frictional torque and may lead to early cup migration and loosening. And there is a concern that larger head diameters and reduced liner thickness may increase polyethylene wear. In this study, we compared early acetabular component migration and wear rates between a group of larger heads using a 2^nd generation HXLP and a group smaller heads using a 1^st generation HXLP.

The larger head group comprising 30 hips underwent THA between February 2010 and March 2011 with the use of a sequentially cross-linked polyethylene liner (X3). 30 patients were included in this study (30 women). Their mean age was 59.3years; mean weight was 53.6kg. Trident HA-coated cementless cups were used and the sizes ranged from 46mm to 56mm (mean 50.5mm). The head diameters were 36mm in 23hips, 40mm in 5 hips, and 44mm in 2hips. All X3 liners were 5.9mm or less in thickness.

A control group was selected from a previous case series that had undergo THA between July 2007 and January 2008 using a 1st generation HXLP liner (Crossfire) by matching age and sex. Therefore 30 patients were included in this study (30 women) too. Their mean age was 60.0 years; mean weight was 55.5kg. The same Trident cups were used and the sizes ranged from 46mm to 56mm (mean 49.5mm). The head diameters were 26mm in 19hips and 32mm in 11hips. The liner thicknesses were 7.8mm or more.

All hips had standardized anteroposterior pelvic digital radiographs performed postoperatively and cup migration was measured on digital radiographs at the immediate postoperative period and two year using EBRA-CUP software. We analyzed horizontal and vertical cup migration distance and the difference in cup anteversion and inclination angle at two years. Additionally, total head penetrarion and polyethylene liner volumetric wear rates were measured using a computer-assited method with PolyWear software.

The larger head group revealed an average of 0.48mm of horizontal migration, 0.75mm of vertical migration, 0.19degree of inclination change, and 1.26 degrees of anteversion change. The control group showed an average of 0.63mm of horizontal migration, 0.36mm of vertical migration, 0.07 degree of inclination change, and 0.88 degree of anteversion change. Based on the EBRA-CUP measurements, there were no cases of significant early loosening which was indicated by more than 1mm of migration, more than 2.5 degree of inclination change, or more than 3.3 degree of anteversion change.

The liner penetration rates were 0.388±0.192mm/yr in the large head group and 0.362±0.178mm/yr in the control group. The difference was not significant (p=0.64.) The volumetric wear rates were 42.8±27.9mm⁁3/yr in the large head group and 42.0±33.0mm⁁3/yr in the control group. Again, the difference was not significant (p=0.94).

No significant early cup migration or increased wear rate were detected in THA with the sequentially cross-linked polyethylene liner and 36mm or large heads at two years.

Background. Migration analysis after total joint arthroplasty are performed using EBRA analysis (Krismer et al., 1997) or - more accurate but also much more cost-intensive and time-consuming – via radiostereometric analysis (RSA). For the latter, additional radiographs from two inclined perspectives are needed in regular intervals in order to define the position of the implant relative to tantalum bone markers which have been implanted during surgery of the artificial joint (Fig. 1). Modern analysis software promises a migration precision along the stem axis of a hip implant of less than 100 μm (Witvoet-Brahm et al., 2007). However, as the analysis is performed semi-automatically, the results are still dependent on the subjective evaluation of the X-rays by the observer. Thus, the present phantom study aims at evaluating the inter- and intra-observer reliability, the repeatability as well as the precision and gives insight into the potential and limits of the RSA method. Materials and Methods. Considering published models, an RSA phantom model has been developed which allows a continuous and exact positioning of the prostheses in all six degrees of freedom (Fig. 2). The position sensitivities of the translative and rotative positioning components are 1 μm and 5 to 24, respectively. The roentgen setup and Model-Based RSA software (3.3, Medis specials bv, Leiden, Netherlands) was evaluated using the SL-PLUS® standard hip stem (size 7, Smith & Nephew, Baar, Switzerland). The inter-observer (10 repetitions) and intra-observer (3 observers) reliability have been considered. Additionally, the influences of the model repositioning and inclination as well as the precision after migration and rotation along the stem axis are investigated. Results and Discussion. Precision along the stem axis was determined to 161 μm (± 230 μm), in the lateral plane 100 μm (± 85 μm) and maximal rotations to 0.524° (± 1.268°). High reproducibility (intra-observer reliability) is reported with relevant influences of the inclination of the implant on the radiograph, in particular for the first clinical scene which serves as a reference. Deviations after translations along the stem axis are 0.37 ± 1.92% and −3.28 ± 6.62% after rotations. In conclusion, the precision given by the software producer of less than 100 μm could not be verified. Beside the limitations from the software, potential sources of errors are the subjective analysis by the observer, a small number of bone markers and the positioning of the implant (patient) during X-ray examination. Though, Model-Based RSA largely outmatches the EBRA approach in terms of measuring implant migration. However, standardization of the X-rays and RSA analysis is recommended

Introduction. Acetabular component positioning, offset, combined anteversion, leg length, and soft tissue envelope around the hip plays an important role in hip function and durability. In this paper we will focus on acetabular positioning of the cup. Technique. The axis of the pelvis is identified intra-operatively as a line drawn from the highest point of the iliac crest to the middle of the greater trochanter. Prior to reaming the acetabulum, an undersized trial acetabular component is placed parallel and inside the transverse ligament, inside the anterior column and projecting posterior to the axis of the pelvis. This direction is marked and the subsequent reaming and final component placement is performed in the same direction. The lateral opening is judged based on the 45-degree angle from the tear drop to the lateral margin of the acetabulum on anteroposterior pelvic radiographs. The final anteversion of the cup is adjusted based on increased or decreased lumbar lordosis and combined anteversion. Methods. Anteroposterior pelvic radiographs of 100 consecutive patients undergoing posterior THR between September 2010 and March 2011 with this method were evaluated for cup inclination angle and anteversion using EBRA software. Results. There were no malalignments or dislocations. The mean cup inclination angle and anteversion were 41 ± 5.1 degrees (range 37.1 – 48.4) and 22.1 ± 4.8 degrees (range 16.6 – 29.3), respectively. Conclusion. This is a reproducible method of cup positioning and with proper femoral component position and restoring leg length, offset, combined anteversion, and balance soft tissue around the hip. These factors affect the incidence of dislocation, infection, reduced wear, and durability

Introduction: Acetabular component positioning, offset, combined anteversion, leg length, and soft tissue envelope around the hip plays an important role in hip function and durability. In this paper we will focus on acetabular positioning of the cup. Technique: The axis of the pelvis is identified intra-operatively as a line drawn from the highest point of the iliac crest to the middle of the greater trochanter. Prior to reaming the acetabulum, an undersized trial acetabular component is placed parallel and inside the transverse ligament, inside the anterior column and projecting posterior to the axis of the pelvis. This direction is marked and the subsequent reaming and final component placement is performed in the same direction. The lateral opening is judged based on 45-degree angle from the tear drop to the lateral margin of the acetabulum on anteroposterior pelvic radiographs. The final anteversion of the cup is adjusted based on increase or decrease of lumbar lordosis and combined anteversion. Methods: Anteroposterior pelvic radiographs of 100 consecutive patients undergoing posterior THR between September 2010 and March 2011 with this method were evaluated for cup inclination angle and anteversion using EBRA software. Results: There were no malalignment or dislocation. The mean cup inclination angle and anteversion were 41 ± 5.1 degrees (range 37.1 – 48.4) and 22.1 ± 4.8 degrees (range 16.6 – 29.3), respectively. Conclusion: This is a reproducible method of cup positioning and with proper femoral component position, restores leg length, offset, combined anteversion, and balances soft tissue around the hip. These factors affect the incidence of dislocation, infection, reduced wear, and durability

Introduction. Cup positioning in total hip arthroplasty (THA) is an important variable for short and long term durability of any hip implant. This novel method utilises internal and external bony landmarks, and the transverse acetabular ligament for positioning the acetabular component. Methods. The cup is placed parallel and superior to the transverse ligament and inside the anterior wall notch of the true acetabulum, and then adjusted for femoral version and pelvic tilt, fixed obliquity, and transverse rotational deformity based on weight bearing pre-operative radiographs. Seventy consecutive THRs (68 patients) were performed using the above technique. The cup radiographic and functional anteversion and abduction angle were measured on post-operative weight bearing pelvic radiographs using EBRA software. Results. The mean follow-up was 8.1 ± 2.4 months (4.3 – 11.8 months). There were no dislocations. The mean anteversion and abduction angle was 41.8 degrees ± 4.6 degrees and 18.5 degrees ± 4.4 degrees, respectively. In 3 hips, the radiographic abduction angle was slightly outside the safe zone of Lewinnek as measured based on the inter-teardrop line. However, when using a weight bearing AP pelvis radiograph to measure functional abduction angle using a horizontal line as a reference, they were all within the normal range. Discussion and Conclusion. The proposed technique utilises intra- and extra-articular bony landmarks, allows for adjustment for lumbosacral angle, abnormal femoral anteversion, and excessive acetabular version. The proposed technique is a reproducible and accurate method for cup placement with posterior exposure

Introduction. Total hip arthroplasty (THR) with non-cemented or hybrid fixation remains one of the most successful procedures performed today. The aim of this study was to assess the safety and efficacy of a hydroxyapatite (HA) coated, hemispherical cup. Material and Methods. Between 2003 and 2007, 223 THAs (210 patients) with peripheral self-locking (PSL) cup and highly cross-linked polyethylene (Crossfire, Stryker, Mahwah, NJ) with minimum 5 years clinical and radiographic follow-up (5–9 years) were analyzed. The mean age was 62.5 years ± 10.8 (range, 32.7 – 86.3) at the time of surgery and the predominant preoperative diagnoses was osteoarthritis (97.8%). 72% were solid cups without screw augmentation and 28% were multi-hole with screw. Clinical analysis included Hospital for Special Surgery (HSS) hip scores at latest follow-up. Detail radiographic analysis was carried out on anteroposterior and false profile views for evidence of osseointegration in all Charnley's zones. Osseointegration was assessed based on presence of Stress Induced Reactive Cancellous Bone (SIRCaB) with trabecular bone hypertrophy 5–15mm extending from the cup, and absence of radiolucency or demarcation. EBRA software was used to assess cup positioning. Results. At final follow up, clinical result were excellent with average HSS score of 34.8. 4% underwent revision for following reasons: dislocation (1.34%), loose stem (0.89%), stem fracture (0.89%), pain/bursitis (0.45%), and infection (0.45%). There were no revisions for failures of fixation. In radiographic analysis, the average functional cup abduction angle and functional anteversion were 41.7° ± 5.2 (range, 30 – 52) and 16.8° ± 6.1 (range, 4 – 30). 96% of the cups were within the safezone of Lewinnek. There was no progressive radiolucency, migration or change in the cup position at final follow-up. The average overall SIRCaB and radial trabeculae in all 3 zones were 47% and 93%, respectively; both were most prevalent in Zone 1. Conclusion. The hemispherical, peripheral press-fit, HA-coated PSL cup has excellent safety and efficacy, appropriate radiographic osseointegration with no mechanical failures at 5 – 9 years. PSL cup has 1 mm increase in the radius at the periphery of the shell to allow for an enhanced initial press fit. Based on our results, supplementary screw with this cup may not lead to better fixation

Introduction. All current methods of cup placement use anterior pelvic plane (APP) as the reference. However, the majority of studies investigating the measurement of anteversion (AV) and abduction angles (AA) are inaccurate since the effect of pelvic tilt and obliquity are not considered. The aim of this study was to describe a reproducible, novel technique for functional cup positioning using internal and external bony landmarks and the transverse acetabular ligament (TAL). Methods. The pelvic obliquity and tilt are measured on the pre-operative weight bearing AP and lateral pelvic radiographs. Intra-operatively, the highest point of the iliac crest is identified and a line is drawn to the middle of the greater trochanter with knee flexed to 90 degrees and leg thigh horizontal to the floor, parallel to the APP. The cup is placed parallel to the TAL and inside the anterior acetabular wall notch, and then is adjusted for the femoral anteversion, pelvic tilt and obliquity. The angle between the drawn line and the cup handle is the operative anteversion. 78 consecutive total hip replacements (76 patients) were performed using this technique. The functional cup orientation was measured on post-operative weight bearing pelvic radiographs using EBRA software. Results. The mean follow-up was 1.2 ± 0.3 years. There were no fracture, dislocation or infection. The mean functional AV and AA were 17.9° ± 4.7° (7.8–28.7) and 41.7° ± 3.8° (33.4–50), respectively. The mean pelvic tilt and obliquity were −3.1° ± 9.7° (−25–9) and −1.5° ± 3.2° (−9.9–7.4), respectively. 96% of functional AV and 100% of functional AA measurements were within the safe zone. Discussion and Conclusion. This is an easy, accurate, and reproducible technique, which uses bony landmarks and TAL, adjusted for femoral anteversion and pelvis tilt and obliquity. Weight-bearing radiographs should be used to standardise the measurements with the goal to reproduce the functional cup orientation within the safe zone

Background. Reasons for revision of metal-on-metal hip resurfacing arthroplasty (MoMHRA) have evolved with improving surgical experience and techniques. Early revisions were often due to fracture of the femoral neck while later revisions are associated with loosening and/or adverse local tissue reactions (ALTR) to wear debris. In some studies, revisions of MoMHRA with ALTR have been complicated by an increased risk of rerevision and poor outcome. The purpose of this study was to investigate the causes of failure and to identify factors that improve outcome following revision of a failed HRA. Methods. From 2001 to May 2015, 180 consecutive HRA revisions were performed in 172 patients. Ninety-nine primary surgeries were done at a HRA specialist centre (99/4211, revision rate: 2.4%), 81 elsewhere. Eight different HRA designs were revised mainly in females (60%). Components’ orientation was measured from radiographs using EBRA. Ion levels were used as a diagnostic tool since 2006 (n=153). Harris-Hip-Score (HHS) was obtained prerevision and at latest follow-up. The initial experience of the first 42 cases (Initial Group) was compared to cases 43–180 (Later Group). Patients of the Later group were noted to have less soft tissue damage, had significantly bigger THA heads implanted at surgery, were educated of the increased complication risk and some wore an abduction brace for 6 weeks. Results. All patients presented with some pain/discomfort. Mean time to revision was 38 months (0–160). Eight HRAs were revised for fracture and 8 for infection. The most common reason for revision was component malpositioning (acetabular 48%, excessive abduction and/or anteversion; femoral 10%) usually associated with high metal ions (62%). The most common intra-operative finding was ALTR (48%) followed by metallosis (36%) and impingement (29%). Metal sensitivity was suspected in 8 patients (6F/2M). There were gender-specific differences in component sizes and causes of failure, with a higher incidence of component malpositioning, osteolysis and elevated metal ions in women. Time to revision in patients with high metal ion levels was shorter with the ASR (21 months, SD:10) in comparison to the BHR (38 months, SD: 25) (p=0.05). For the whole cohort, HHS significantly improved post revision (93, 42–100) (p<0.001). Fourteen complications (9 dislocations; 5 infections) and 9 re-revisions occurred. Outcome {HHSpost-op (p=0.04), complication and re-revision rates (p=0.005)} was significantly better in the Later Group compared to the Initial group. The incidence of complications/re-revisions significantly reduced since the introduction of metal ions (p=0.004). The presence of ALTR did not significantly affect outcome (p=0.65). However, patients with ALTR in the Later group (n=51) had significant reduced complication(p=0.005) and re-revision(p=0.016) rates in comparison to those in the Initial Group. Conclusion. Component malpositioning is the most common cause of HRA failure. Metal ion measurements are an excellent tool to detect wear at an early stage. The revision analysis highlights the importance of surgical experience, indications and prosthesis design. Use of ion levels, big THA-heads and patient education/compliance were identified as factors improving outcome following HRA revision. Patients with soft tissue reactions can have good outcome if operated prior to extensive soft tissue destruction

Introduction. The purpose of this study was to evaluate the in vivo migration patterns of a polished femoral component cemented line-to-line using EBRA –FCA. Methods. The series included 164 primary consecutive THAs performed in 155 patients with a mean age of 63.8 years. A single prosthesis was used combining an all-polyethylene socket and a 22.2 mm femoral head. The monoblock double tapered femoral component made of 316-L stainless steel had a highly polished surface (Ra 0.04 micron) and a quadrangular section (Kerboull(r) MKIII, Stryker). The femoral preparation included removal of diaphyseal cancellous bone to obtain primary rotational stability of the stem prior to the line-to-line cementation. Stem subsidence was evaluated using EBRA-FCA software which accuracy is better than ± 1.5 mm (95% percentile), with a specificity of 100% and a sensitivity of 78% for detection of migration of more than 1.0 mm, using RSA as the gold standard. Results. At the minimum 15-year follow-up, 73 patients (77 hips) were still alive and had not been revised at a mean of 17.3 ± 0.8 years, 8 patients (8 hips) had been revised for high polyethylene wear associated with periacetabular osteolysis, 66 patients (69 hips) were deceased, and 8 patients (10 hips) were lost to follow-up. Among the 8 revision procedures, the femoral component was loose in 3 cases. A total of 1689 radiographs were digitized of which 263 were excluded by the software for lack of comparability, leaving 142 hips with adequate follow-up evaluation data. At last follow-up, the mean subsidence of the entire series was 0.63 ± 0.49 mm (0 – 1.94 mm). When using a 1.5 mm threshold, 4 of the 142 stems were considered to have subsided

Introduction. Squeaking is a potential problem of all hard on hard bearings yet it has been less frequently reported in metal-on-metal hips. We compared a cohort of 11 squeaking metal-on-metal hip resurfacings to individually matched controls, assessing cup inclination and anteversion between the groups to look for any differences. Methods. We retrospectively reviewed the patient records of 332 patients (387 hip resurfacings) who underwent hip resurfacing between December 1999 and Dec 2012. 11 hips in 11 patients were reported to squeak postoperatively. Each of these patients, except one, were matched by age, sex, BMI and implant to 3 controls. The final patient only had one control due to his high BMI. The latest post-operative radiographs of the squeaking group and controls were analysed using EBRA (Einzel-Bild-Roentgen-Analysis, University of Innsbruck, Austria) software to evaluate cup inclination and anteversion. Results. Post- operative audible squeaking occurred in 11 out of 387 hips (2.84%). The mean follow up of the squeaking group was 88.6 months (19–131 months). The mean time to squeak was 11.3 months (3–22 months). 8 (73%) patients were male, 10 (91%) patients had a Birmingham hip resurfacing and 9 (82%) patients had an operation on the left hip. The mean inclination angle of the cups in the squeaking group was 48.4° (43.9°–55.4°) compared to 50° (37.8° −63°) in the control group. The mean anteversion of the cups in the squeaking group was 17.1°(6.3°–25.7°) compared to 14.6° (4.3° −33.5°) in the control group. There was no statistically significant difference between the cases and their controls for cup inclination (p = 0.36) or cup anteversion (p = 0.31). The mean head size in the squeaking group was smaller at 49.3 mm (46 mm-54 mm), compared to 51.4 mm (48 mm-54 mm) in the control group (p = 0.026). The mean cup size in the squeaking group was also smaller at 56.5 mm (54 mm-62 mm), compared to 57.9 mm (48 mm-60 mm) in the control group (p = 0.007). Overall, 4 (40%) male patients in the squeaking group had a head size less than 50 mm, compared to 0 (0%) in the control group. 3 (27%) patients with squeaking resurfacings underwent revision surgery. 1 (9%) at 72 month for a pseudotumour, 1 (9%) at 114 months for persistant squeaking and 1 (9%) at 117 months for a subtrochanteric fracture after a fall. Conclusions. No difference was found between the radiographic inclination or anteversion of squeaking metal-on-metal hip resurfacing cups compared to a control group. Male patients with squeaking hips were noted to have smaller head and cup sizes than their controls

Introduction. Total hip arthroplasty (THR) is one of the most successful procedures performed today. Uncemented acetabular components have by and large replaced cemented cups. As such, optimal fixation, bony ingrowth with longevity, and safety is highly demanded. In this study, we look at the safety and efficacy of the Stryker® Trident PSL™ acetabular component based on radiographic and clinical analysis. Materials and Methods. We looked at 860 consecutive patients between 2003 and 2007. Of these, 231 consecutive patients had a minimum 5 year follow up. All cases were for degenerative joint disease (DJD), except 2 for dysplasia, 1 for avascular necrosis (AVN), 1 femoral neck nonunion. Average Hospital for Special Surgery (HSS) hip scores at final follow up were recorded. Radiographic analysis included classification based on Delee and Charnley's zones 1–3. Osseointegration was assessed based on presence of SIRCAB (stress induced reactive cortical hypertrophy of bone), demarcation around the implant, stress shielding, presence of radial trabeculae, absence of radiolucency, type of bearing, presence of preoperative protrusion, violation of Kohler's line. EBRA software was used to assess acetabular inclination and version. Results. Of 231 hip replacements analyzed, 114 were male, 117 were female. The average age was 63 (range 33–87); height was 67.5 inches; BMI was 27; 3 patients had a preoperative diagnosis of DDH, 2 had AVN, 1 femoral neck nonunion, and 1 case of rheumatoid arthritis (RA), with the remainder of patients diagnosed with DJD. cup abduction angle was 41.7° with average of 17.4° of anteversion. Average HSS functional score was excellent at latest follow up was 34, with most patients not relying on any assistive devices; There were no revisions performed due to mechanical failures or due to failure to osseointegrate. Complications include 1 infection (0.43%); and 4 dislocations (1.73%). Osseointegration was measured by separating the acetabulum into DeLee and Charnley zones and assessed by analyzing:. a). stress induced hypertrophic reaction of cortical bone (SIHRCaB): zone 1 (75.8%), zone 2 (11.7%), zone 3 (51.9%). b). Radial trabeculae: zone 1 (94.8%), zone 2 (93.5%), zone 3 (92.6%). c). Absence of radiolucency: zone 1 (96.1%), zone 2 (97%), zone 3 (96.1%). No association of bearing surfaces to survivorship was noted as metal femoral heads were used in 72.7% of cases while a ceramic bearing was used in 25.1%. Conclusion. The Trident PSL acetabular component was examined in a large, consecutive series by a single surgeon with a minimum 5–9 year follow up. We have demonstrated excellent radiographic osseointegration at latest follow up with no mechanical failures, high survivorship, and excellent clinical outcome scores. It continues to be a reliable option for primary acetabular reconstruction

Introduction. Total hip prostheses which use a ceramic head within a metal liner are a relatively recent innovation. As such, survivorship rates from independent centres alongside explant analysis are rare. The early clinical experience with this novel ceramic-on-metal (CoM) bearing couple is reported alongside explant analysis of failed devices. Methods and materials. All CoM hips implanted between 2008 and 2009 at a single hospital by a single surgeon were reviewed. Radiographs were analysed using EBRA software to determine acetabular cup inclination and anteversion angles. Blood metal ion concentrations were measured using inductively coupled plasma mass spectroscopy (ICPMS). Explants were measured for bearing surface and taper wear using a high precision co-ordinate measuring machine (Mitutoyo Legex 322, manufacturer's claimed accuracy 0.8µm). The roughness of the articulating surfaces of heads and liners was measured with a non-contact profilometer (ZYGO NewView 5000, 1nm resolution). Results. In 56 patients 56 CoM hips were implanted. Mean (range) age was 64 years (34–87). There were 41 females and 15 males. Patients were followed-up for a mean of 1.5 years. Three hips were revised at mean of 1.2 years (2 female, 1 male) with a further 3 listed for revision under 1.5 years giving an overall failure rate of 10.7%. All these patients reported with pain. X-rays of failed devices showed a characteristic pattern of femoral stem loosening. Serum cobalt and chromium were less than 2 micrograms/L. Explant analysis of the three revised hips showed wear at the liner rim in each case. In two of these cases the wear extended completely around the circumference. The wear volumes were 4.1, 2.0 and 2.3mm. 3. respectively. The ceramic heads were unworn but some transfer of metal could be seen visually. There was no significant wear or deformation at the taper junctions. Typical ceramic head roughness values were 3nm Ra and so most of the surface area of the heads remained in a pristine condition. Discussion. The high early failure rate using a COM articulation is concerning. Explant analysis suggests equatorial contacts with propagation of high frictional forces distally. These forces may have caused early loosening of the femoral stems. Orthopaedic surgeons and bioengineers need to be aware of this new mechanism of failure in this novel biomaterial coupling which is associated with low metal ions

Introduction. Acetabular fixation is one of the major factors affecting long-term longevity and durability of total hip arthroplasty (THA). Limited data exist regarding mid-term performance of modern non-cemented rim-fit cups with HA coating. The aim of this study was to assess the minimum 5 year clinical and radiographic performance of PSL cups. Therefore we retrospectively analyzed results of this component in patients that had adequate followup from a prospective institutional database. Materials and Methods. A retrospective analysis of a prospective database was performed to identify patients that underwent non-cemented THA between 2003 and 2007. 223 primary THA (210 patients) were performed by single surgeon via posterolaeral approach using a grit-blasted, HA coated rim-fit design and highly cross-linked polyethylene and were followed with minimum 5 years. The mean age was 62.5 years ± 10.8. The majority of the stems were non-cemented (87%) and the majority of the femoral heads were metal (75%), 22- or 28-mm diameter. 72% of the cups were solid and 28% were multi-hole. Clinical assessment included the Hospital for Special Surgery (HSS) hip score [18] at final follow-up, and Kaplan-Meier survivorship. All patients received pre- and post-operative anteroposterior (AP) weight bearing pelvis radiograph as well as a false profile view of the hip. Cup positioning was analyzed using the EBRA software (Einzel-Bild-Roentgen-Analysis; University of Innsbruck, Innsbruck, Austria) for functional abduction angle, anteversion, and cup migration. Osseointegration was assessed on the DeLee and Charnley's zones on both AP and false profile views. Osseointegration was defined based on the following characteristics:. presence of Stress Induced Reactive Cancellous Bone (SIRCaB), where new bone condensation (not apparent on preoperative radiographs) was present at the load bearing area of the cup (Figure 1). presence of radial trabeculae that project in continuum from the shell into the pelvis, suggesting integration of the trabecular bone onto the metal surface at the load bearing area, (Figure 2). absence of radiolucency. Radiolucency was determined by radiolucent lines that were at least 1–2 mm wide and were seen in sequential radiographs, not apparent on the initial postoperative radiograph. Linear and rotational migration was defined as > 3 mm or > 5°change in the cup position, respectively, as measured on serial radiographs. Any changes in cup position or presence of circumferential radiolucencies were considered as loosening. Results. The average duration of follow-up was 6.2 ± 1.1 years (5 – 10 years). The mean HSS score was 34.8 ± 5.0 (19 – 40). There was an overall revision rate of 3.6% (8 cases) with Kaplan-Meier survivorship for all causes of 96.4% (95% CI: 0.92 – 0.98). There was one periprosthetic femur fracture. One stem was revised for fracture at the truniun/neck junction. There were 2 dislocation (0.9%); in one hip the cup was revised and the other was treated with a constrained liner. In 3 THAs (1.3%), stems were revised for loosening/failure of osseointegration (2 non-cemented stems, 0.9%) and osteolysis (one cemented stem, 0.4%). One THA (0.45%) underwent two stage revision for treatment of periprosthetic infection. There were no revisions for cup loosening or osteolysis or ceramic head fractures. The Kaplan-Meier survivorship for cup revision for any failure was 99% (95% CI: 0.96 – 0.99) and for mechanical failure was 100% (95% CI: 0.97 – 1). In radiographic analysis, the average functional cup abduction angle and anteversion were 41.7° ± 5.2 (range, 30 – 52) and 16.8° ± 6.1 (range, 4 – 30). 96% of the cups were within the safezone of Lewinnek. There were no migration or change in cup position in any cases. Presence of SIRCaB and radial trabeculae in all 3 zones were seen in 47% and 93% of cups, respectively; both were most prevalent in Zone 1. The absence of radiolucent line was observed in 96% of cases. In 161 THAs (72%), no screws were used due to excellent initial stability. Detail radiographic osseointegration assessment in the non-screw fixation group (as compared to the THAs with screw fixation) showed significantly higher incidence of SIRCaB (49% versus 39.7%, p=0.05) and radial trabeculae (97.5% versus 94.7%, p=0.001). There was also significantly less radiolucent lines in the non-screw fixation group (p=0.001). Discussion. No evidence of radiographic failure to osseointegrate was found in this study as evidenced by absence of radiolucency, evidence of radial trabeculae, and a reactive condensation of new bone to the well-fixed acetabular shell. Interestingly, we found that the solid designs had significantly better osseointegration when compared to multi-hole designs. In this single surgeon series with mid-term follow-up reiterates that the HA-coated hemispherical rim-fit acetabular component has excellent radiographic osseointegration, clinical outcomes and high survivorship for mechanical failures

Background:. Numerous studies have reported the importance of acetabular component positioning in decreasing dislocation rates, the risk of liner fractures, and bearing surface wear in total hip arthroplasty (THA). The goal of improving acetabular component positioning has led to the development of computer-assisted surgical (CAS) techniques, and several studies have demonstrated improved results when compared to conventional, freehand methods. Recently, a computed tomography (CT)-based robotic surgery system has been developed (MAKO™ Robotic Arm Interactive Orthopaedic System, MAKO Surgical Corp., Fort Lauderdale, FLA, USA), with promising improvements in component alignment and surgical precision. The purpose of this study was to compare the accuracy in predicting the postoperative acetabular component position between the MAKO™ robotic navigation system and an imageless, CAS system (AchieveCAS, Smith and Nephew Inc., Memphis, TN, USA). Materials and Methods:. 30 THAs performed using the robotic navigation system (robotic cohort) were available for review, and compared to the most recent 30 THAs performed using the imageless, CAS system (CAS cohort). The final, intraoperative reading for acetabular abduction and anteversion provided by each navigation system was recorded following each THA. Einsel-Bild-Roentgen analysis was used to measure the acetabular component abduction and anteversion based on anteroposterior pelvis radiographs obtained at each patient's first, postoperative visit (Figure 1). Two observers, blinded to the treatment arms, independently measured all the acetabular components, and the results were assessed for inter-observer reliability. Comparing the difference between the final, intraoperative reading for both acetabular abduction and anteversion, and the radiographic alignment calculated using EBRA analysis, allowed assessment of the intraoperative predictive capability of each system, and accuracy in determining the postoperative acetabular component position. In addition, the number of acetabular components outside of the “safe zone” (40° + 10° of abduction, 15° + 10° of anteversion), as described by Lewinnek et al., was assessed. Lastly, the operative time for each surgery was recorded. Results:. In the robotic cohort, the mean, absolute difference between the intraoperative reading and the postoperative alignment was 4.3° + 2.3° for acetabular abduction, and 3.2° + 2.3° for acetabular anteversion. In comparison, in the CAS cohort, the mean, absolute difference was 3.7° + 2.8° for acetabular abduction (p = 0.4), and 3.8° + 2.7° for acetabular anteversion (p = 0.4). In both cohorts, all of the acetabular components were placed within 40° + 10° of abduction. In the robotic cohort, 27 of 30 components were placed within 15° + 10° of anteversion, versus 25 of 30 components in the CAS cohort (p = 0.7). The interobserver correlation coefficients for measurement of both the acetabular abduction and anteversion were good (p = 0.83 and 0.79, respectively). A statistically significant difference was appreciated between the two cohorts for operative times, with a mean operative time of 120.2 + 8.9 minutes in the robotic cohort (vs. 73.6 + 17.1 minutes in the CAS cohort, p < 0.01). Discussion:. This study demonstrates the robotic navigation system to require significantly increased operative times, while providing no significant advantage over the imageless, CAS system with regards to predicting the postoperative acetabular component position

It has been suggested that metal ion levels are indicative of in vivo bearing performance of metal-on-metal hip replacements. A cobalt or Chromium level of 7μg/L or higher is proposed to be indicative of a bearing malfunction and the need for clinical intervention. Component design, size, acetabular orientation, patient gender and activity level have been suggested as factors leading to accelerated wear and elevated metal ions. The contact patch to rim (CPR) distance is a calculation that describes the distance from the point where a theoretical joint reaction force intersects the cup to the acetabular rim for a patient in standing position, dependent on the coverage, size, and orientation of the acetabular component. It has been suggested that CPR distance determines the hip joint susceptibility to edge loading, and the risk for increased wear and high ion levels (Langton et al JBJS Br 91: 2009). This study examined the effects of patient activity, gender, and CPR distance on serum metal ion concentrations in a series of patients treated with one type of metal on metal hip resurfacing arthroplasty (MMHRA) performed by one surgeon. 182 patients (73 females and 109 males)with a unilateral Conserve Plus (WMT, TN USA) MMHRA and had who had provided blood for metal ion analysis data from December 2000 to June 2011 were retrospectively studied. Only measurements made more than 12 months after surgery were included in order to exclude hips that had yet to reach steady-state wear. For patients with multiple draws, the most recent qualifying draw was used. Activity level was assessed by the UCLA activity score. The mean age was 51.5 years (20.0 to 77.5 years). The mean follow-up time for the last blood draw was 70 months (range, 12 to 165). Serum cobalt (CoS) and chromium (CrS) levels were analyzed using inductively coupled plasma mass spectrometry in a specialized trace element lab. Using acetabular abduction and anteversion measured by EBRA, component size, and reported coverage angle of the acetabular component, the CPR distance was calculated as previously described. Multiple logistic regression was performed to identify significant relationships between high metal ion levels (7 μg/L or greater) and gender, activity and CPR distance. The median CoS level for the entire cohort was 1.13 μg/L (range, 0.15 to 175.30), and the median CrS level was 1.49 μg/L (range, 0.06 to 88.70). The average CPR distance was 13.8 mm (range, 3.2 to 22.1). There was a significant association between low CPR values and CoS and CrS. There was a 37-fold increase in the risk of CoS >7μg/L (p=0.005) and 11-fold increase in the risk of CrS > 7μg/L (p=0.003) when CPR distance was 10 mm or less. No associations were shown for gender and UCLA activity scores. CPR distance was found to be a reliable predictor of ion levels > 7μg/L and appears to be a useful indicator to evaluate the multi-factorial process of edge-loading and wear. Patients with a low CPR distance should be monitored for increased metal ion levels

Introduction. Tribological studies have described a characteristic wear pattern of metal-on-metal hip resurfacings (MoMHRAs) with a run-in period followed by a ‘bedding-in’ phase minimising wear or by an increasing wear patch with edge loading. The use of metal ions as surrogate markers of in-vivo wear is now recommended as a screening tool for the performance of MoMHRAs. The aims of this retrospective, single-surgeon study were to measure ion levels in unilateral MoMHRAs at different stages during the steady-state in order to study the evolution of wear and factors affecting it. Methods. 218 consecutive patients with minimum two serum ion measurements were included. The mean age at surgery was 52.3 years, the first assessment was made at a mean of 2.5 years (11 months–8 years) and the last assessment at a mean of 4.6 years post resurfacing (2– 12 years). Ion level change was defined as Ion level at last assessment minus Ion level at first assessment. Ten different resurfacing designs were implanted, the majority being BHR (n=104), Conserve plus(n=55) and ASR (n=25). The median femoral component size was 50 mm (38–59mm). Radiological assessment of acetabular component orientation was made with EBRA. Results. For the whole cohort a significant reduction in Chromium (Cr) levels between initial [2.6 μg/ml (SD: 6.8)] and last assessment [1.9 μg/ml (SD: 8.3)] was found (p= 0.004). Cobalt (Co) levels were similar at initial [1.7 (SD: 7.7)] and last [1.8 (SD: 10.6)] follow-up (p=0.78). Cr levels increased in 31% and Co increased in 46% of patients. There was a significant ion level increase in 5% of patients. There was no significant difference between genders (p= 0.4) or implant designs (p = 0.07), but a trend of higher ions at last follow up with the ASR implants in comparison to BHR and C+. Neither component size (p=0.4) nor acetabular orientation (p=0.46) correlated with change in ion levels. However, a CPR distance (contact patch-rim) of <10mm was associated with an increase in Cr levels over time (p= 0.042). Patients with increasing ion levels had significantly lower Harris Hip Scores (p=0.038). Discussion. The analysis of the evolution of ion levels in unilateral hip resurfacing after the run-in phase demonstrates an overall decrease of Cr levels but no significant change in Co levels. This in vivo finding is consistent with tribocorrosion studies showing the formation of a passive protective film on the articulating surfaces after the initial wear-in, preventing further corrosion. From that point on, provided there is no edge loading causing increased surface wear, ions are mainly formed by corrosion of the particulate debris generated during the run-in phase. In vitro studies have shown a higher dissolution of the more soluble Co from the debris while Cr remains in solid form with less ion formation. In a number of cases in our study, ion levels continued to increase, indicating ongoing surface wear. These increasing ion levels were correlated with a lower coverage angle more prone to edge loading and with the development of clinical symptoms

INTRODUCTION. Metal-on-metal hip resurfacing arthroplasty (MoMHRA) is a surgical option in the treatment of end-stage hip disease. The measurement of systemic levels of metal ions gives an insight into the wear occurring and is advocated by regulatory bodies as routine practice in the assessment of resurfaced hips. However, the acceptable upper levels of Chromium (Cr) and Cobalt (Co) ions concentration with clinical significance still have to be established. The aim of this study is to address this issue in unilateral and bilateral resurfaced hips. METHODS. 453 patients with unilateral MoMHRA and 139 patients with bilateral MoMHRA at >12 months postoperative were retrospectively identified from an independent hip specialist's database. Routine metal ion levels were measured at last follow-up (ICPMS protocol). Radiological assessment included measurement of acetabular component orientation using EBRA, calculation of contact patch to rim (CPR) distance, and evaluation for any adverse X-ray findings. The cohort was divided into the well functioning group (Group A) and the non-well functioning group (Group B). A well functioning resurfacing gad to fulfil all of the following criteria (bilateral patients had to fulfil criteria for both hips): no patient reported hip complaints, no surgeon detected clinical findings, HHS> 95, CPR distance> 10mm, no abnormal radiological findings and no further operation scheduled. Upper levels (acceptable limits) of Cr/Co were considered to be represented by the top margin of the box-whisker plot [upper limit = 75. th. quartile value + (1.5 x interquartile range)] in Group A. RESULTS. 251 unilateral MoMHRAs patients (55%) and 58 patients with bilateral MoMHRAs (42%) comprised Group A. The majority of males were in Group A compared to the majority of females who belonged in Group B (p<0.001); subsequently Group A patients had bigger size components (p<0.001). Unilateral Group A [Cr: 2.0 µg/l (SD: 1.5)/ Co: 1.8µg/l (SD: 1.2)] patients had significantly lower ions than Group B [Cr: 7.3µg/l (SD: 17.3)/ Co: 6.6µg/l (SD: 18.1)] patients (p <0.001). Similarly, Group A bilateral patients [Cr: 3.8µg/l (SD: 2.7)/ Co: 2.8µg/l (SD: 1.9)] had significantly lower ions that Group B [Cr: 10.7µg/l (SD: 16)/ Co: 8.5µg/l (SD: 15.8)]. The upper levels (safe were: Cr: 4.6µg/l / Co: 4.0µg/l for unilateral MoMHRAs and Cr: 7.4µg/l / Co: 5.0µg/l for bilateral MoMHRAs. Unilateral MoMHRAs had significantly higher ion levels compared to bilateral patients (p <0.001). Sensitivity and specificity of these upper levels in predicting poor function were respectively 25% and 95% for Cr and 22% and 96% for Co. DISCUSSION. The findings of this study suggest that both unilaterally and bilaterally resurfaced patients with well functioning implants have low metal ion levels with upper levels of Cr: 4.6µg/l / Co: 4.0µg/l for unilateral MoMHRAs and Cr: 7.4µg/l / Co: 5.0µg/l for bilateral MoMHRAs These results indicate that the upper acceptable limit of metal ion levels in resurfaced hips is lower than the previously MHRA recommended threshold, however the study was conducted with very low tolerance for what was considered a clinically problematic hip. Well-functioning bilateral resurfacing have higher ion levels compared to well-functioning unilateral resurfacing