Objectives.
Abstract. Objectives. Osteoporotic fractures tend to be more challenging than fractures in healthy bone and the efficacy of metal screw fixation decreases with decreasing bone mineral density making it more difficult for such screws to gain purchase. This leads to increased complication rates such as malunion, non-union and implant failure (1).
Introduction. In recent years, there has been a growing interest in
Research in orthopaedics is now moving away from permanent metallic implants, and looking towards the use of
Introduction: Accelerated rehabilitation programs following ACL reconstruction require adequate fixation strength. Staple fixation of grafts outside the tibial tunnel has been shown to have fixation strength comparable to interference screws. The use of
Purpose: This work revealed the advantages of percutaneous suture of the Achilles tendon using an improved technique with entirely resorbable material. Material and methods: Thirty cases of subcutaneous tears were operated on two to ten days after the accident (range 24 hr – 7 weeks). We used a 4-thread resorbable V-suture anchored in the calcaneum and, after blocking the ankle in the equine position, on the proximal fragment using two
This prospective randomized multicenter study compares two methods of bone defect treatment in tibial plateau fractures: a
Purpose: The aim of this work was to evaluate the short- and long-term biocompatibility, tolerance and tissue response after implantation of an intersomatic
Different 3D printing techniques for orthopaedic ceramic implants fabrication were compared. Stereolithography of calcium-phosphate slurries makes possible to achieve pre-determined pore size (50 mkm and more) and porosity of 70–80%. For the first time ceramic implants based on double calcium alkali metal phosphates (rhenanites) with given architecture serving good osteoconductivity as well as high resorptivity and strength (up to 10 MPa) were obtained. Development of biomaterials based on calcium phosphates for orthopaedics is an important area of modern materials science. Chemical, physical and mechanical compatibility of this materials is a primary goal for this field. An ideal implant should gradually dissolve and be replaced by the new bone tissue in the patience body. Bone is a multilevel organic/inorganic composite and the main inorganic compound is hydroxyapatite (HA, Ca. 10. (PO. 4. ). 6. (OH). 2. ). Due to this, biomaterials based on HA are widely used, along with biomaterials based on tricalcium phosphate (TCP, Ca. 3. (PO. 4. ). 2. ); however, low solubility of HA (lowest soluble phosphate) as well as TCP does not meet all of the requirements that biomaterials should have. In this work decreasing of the crystal lattice energy approach was used as a strategy of improving the solubility. Modifying the chemical composition by replacing Ca. 2+. cation in the TCP structure by a singly charged alkali metal cation leads to structural changes from TCP to CaMPO. 4. (M=Na, K) – rhenanite. This work focuses on using double calcium alkali metal phosphates Ca. (3 – x). М. 2x. (PO. 4. ). 2. (x = 0–1, М = Na, K) as
Objectives: Advances in biomedical engineering have led to a thorough understanding of the body’s own capacity for ACL healing if provided the correct impetus—a long-term
These results support the use of an injectable, in situ hardening calcium phosphate paste to prevent the early loss of calcaneal height and maintain a more anatomic calcaneal reduction. The purpose of this prospective randomized controlled trial was to determine whether ORIF plus an injectable
Summary Statement. A resorbable and biocompatible polymer-based scaffold was used for the proliferation and delivery of adipose derived stromal cells, as well as delivery of a cell growth/differentiation promoting factor for improved tendon defect regeneration. Introduction. Surgeons perform thousands of direct tendon repairs annually. Repaired tendons fail to return to normal function following injury, and thus require continued efforts to improve patient outcomes. The ability to produce regenerate tendon tissue with properties equal to pre-injured tendon could lead to improved treatment outcomes. The aim of this study was to investigate in vivo tendon regeneration using a biodegradable polymer for the delivery of adipose derived stromal cells (ADSCs) and a polypeptide, growth/differentiation factor-5/(GDF-5), in a tendon gap model. Patients & Methods. Female Fischer 344 rats underwent unilateral Achilles tenotomies. Defects were left un-repaired (Group 1-control), bridged using electrospun 65:35 polylactide-co-glycolide (PLAGA) tubular scaffolds (Group 2), PLAGA/ADSCs (Group 3), or PLAGA/GDF-5 (Group 4) scaffold composites. The plantaris was left intact. Operative limbs were immobilised for 10–14 days, followed by unrestricted activity. The rats were sacrificed at 4 weeks or 8 weeks after surgery, and tendons were assessed with histological, biochemical, and mechanical analyses. Results. PLAGA, PLAGA/ADSCs, and PLAGA/GDF-5 groups showed increased collagen I gene expression at both the 4 and 8 week time points (p<0.05). Tenomodulin (Tnmd) is the mature tendon phenotype marker unique to tendon tissue. Both the PLAGA/ADSCs and PLAGA/GDF-5 groups demonstrated increased tenomodulin expression at 4 and 8 weeks (p<0.05). Ultimate tensile load strength was improved in all PLAGA groups (2, 3, and 4) versus the control. Both composite groups (2 and 3) showed improved collagen deposition, as indicated by increased Collagen Area Fraction (CAF), approaching that of normal tendon at 8 weeks (p<0.05). Scaffold resorption was evident at 4 weeks, with complete replacement of the polymer with regenerate tissue and minimal gap formation at 8 weeks without evidence of an adverse inflammatory reaction. Defects bridged using the scaffold seeded with ADSCs showed improved collagen organization and increased modulus of elasticity compared with controls as well as properties approaching those of native tendon. Discussion/Conclusions. These results demonstrate that a tubular
Objective: The high incidence of retear following primary rotator cuff tendon (RCT) repair necessitates new strategies for tendon footprint augmentation. This study’s objective was to evaluate the SeriCuff™, a non-mammalian derived silk-based long-term
Objectives. We hypothesise that a long-term
Objectives. Osteochondral injuries, if not treated adequately, often lead
to severe osteoarthritis. Possible treatment options include refixation
of the fragment or replacement therapies such as Pridie drilling,
microfracture or osteochondral grafts, all of which have certain
disadvantages. Only refixation of the fragment can produce a smooth
and resilient joint surface. The aim of this study was the evaluation
of an ultrasound-activated
Introduction. The incidences of fragility fractures, often because of osteoporosis, are increasing. Research has moved towards
Introduction. Cerament, a
Aim. Implant-associated osteomyelitis is a devastating complication with poor outcomes following treatment, especially when caused by antibiotic-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). A large animal model of a two-stage revision to treat MRSA implant-associated osteomyelitis has been developed to assess novel treatments. A
Background.