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Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 245 - 245
1 Mar 2013
Lustig S Scholes C Oussedik S Appleyard R Parker D
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Introduction & aims

Osteonecrosis may be triggered by bone temperature above 45°C during routine orthopaedic bone cuts using power-driven saws, with potentially negative impacts on bone healing. A new oscillating-tip saw blade design (Precision; Stryker, Kalamazoo, Mich) has been recently developed but the saw blade design may influence the amount of heat generated. We have therefore sought to compare the bone temperature during a standardised cutting task with two different saw blade designs.

Method

Three pairs of human cadaveric femora were obtained. Each femur was clamped and a distal femoral cutting jig was applied. An initial cut was performed to visualise the distal metaphyseal bone. The cutting block was then moved 2 mm proximal and a further cut performed, measuring the temperature of the bone with an infra-red camera. This was repeated, moving the block 2 mm proximal with each cut, alternating between a standard oscillating saw blade and the “Precision” saw blade. The density of the cut bone was then established from a CT scan of each specimen performed prior to the experiment.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 299 - 299
1 Mar 2013
Parker D Lustig S Scholes C Kinzel V Oussedik S Coolican M
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Purpose

Patient-matched instrumentation is advocated as the latest development in arthroplasty surgery. Custom-made cutting blocks created from preoperative MRI scans have been proposed to achieve perfect alignment of the lower limb in total knee arthroplasty (TKA). The aim of this study was to determine the efficacy of patient-specific cutting blocks by comparing them to navigation, the current gold standard.

Methods

60 TKA patients were recruited to undergo their surgery guided by Smith & Nephew Visionaire Patient-Matched cutting blocks. Continuous computer navigation was used during the surgery to evaluate the accuracy of the cutting blocks. The blocks were assessed for the fit to the articular surface, as well as alignment in the coronal, sagittal and rotational planes, sizing, and resection depth.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 11 | Pages 1455 - 1456
1 Nov 2012
Oussedik S Gould K Stockley I Haddad FS

Peri-prosthetic infection remains a leading cause of revision surgery. Recent publications from the American Musculoskeletal Infection Society have sought to establish a definition of peri-prosthetic infection based on clinical findings and laboratory investigations. The limitations of their approach are discussed and an alternative definition is proposed, which it is felt may better reflect the uncertainties encountered in clinical practice.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLI | Pages 155 - 155
1 Sep 2012
Widmer B Conrad L Scholes C Oussedik S Coolican M Parker D
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Computer assisted surgical navigation has played an increasingly central role in total knee arthroplasty (TKA). Given the recognized importance of subtle component position changes in knee function, navigation has emerged as a promising tool for reducing the occurrence of significant malalignment. The ability of this technology to reliably measure multiple parameters intraoperatively allows analysis to possibly identify a correlation between intraoperative computer assisted surgical navigation data and functional outcomes of patients undergoing elective total knee arthroplasty.

Intraoperative navigation data was collected for 121 patients undergoing cemented, posterior stabilized TKA. Three forward stepwise regression analyses were performed to associate intraoperative coronal alignment correction, tibiofemoral external rotation, and alignment under varus and valgus stress with one year outcomes, including range of motion, Oxford and SF-36 scores.

The amount of alignment correction and the maximum flexion achieved intraoperatively were significantly correlated (p <0.05, R-sq = 13%) with clinically measured maximum flexion at one year. Maximum flexion achieved intraoperatively, external tibiofemoral rotation and maximum varus under stress were also significantly associated (p < 0.05, R-sq = 31%) with the physical component of the SF-36 outcome score.

Analyses of computer navigation in TKA to date have primarily focused on precision of sagittal plane correction. Alternatively we have identified four intraoperative parameters that correlate with functional outcome at one year. Correct intraoperative interpretation of navigation data may allow surgeons to make subtle changes in real time to produce superior short-term outcomes for patients.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLI | Pages 4 - 4
1 Sep 2012
Oussedik S Scholes C Leo S Ferguson D Roe J Parker D
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Computer navigation has been shown to improve the accuracy of total knee replacement (TKR) when compared to intra or extra osseous referencing. Currently the surgical transepicondylar axis (TEA) is used to help determine femoral component rotation. This relies on the surgeon identifying medial and lateral epicondyles intra-operatively. This process has been shown to have a high variability and operator dependency. The functional flexion axis (FFA) of the femur is a kinematically derived reference axis which has previously been shown in a cadaveric model to correspond well with the transepicondylar axis. This study was therefore designed to evaluate its accuracy in vivo.

50 patients undergoing total knee replacement under the care of the three senior authors were prospectively recruited. A preoperative CT scan was obtained and the TEA evaluated by 2 independent clinicians. TKR was undertaken in the standard fashion using Stryker navigation. The FFA was derived at 3 time points during the procedure: pre-incision, post osseous registration and following component implantation. The deviations of the FFA and surgical TEA (surTEA) to the CT-derived TEA (ctTEA) was calculated and comparisons drawn between the 2 methods with respect to validity, as well as within and between-patient reproducibility.

While the FFA results were highly correlated between pre and post-arthrotomy (r = 0.89), the post-incision FFA (−1.60+/−3.7) was significantly internally rotated (p<0.01) relative to the pre-incision FFA (−2.50+/−3.4). In addition the surgical TEA (−0.40+/−3.6) was significantly internally rotated (p = 0.02) relative to the post-incision FFA (1.80+/−3.7) for the combined data from all 2 surgeons. However, when examined individually, 1 of the 2 surgeons showed no significant difference between the FFA and TEA. In addition, the two methods demonstrated comparable between-patient variability in the knee axis, although surgeon-dependent patterns remained.

The FFA has been shown to be of equivalent accuracy to the surgical TEA but surprisingly does not avoid its operator-dependency. Further evaluation of the FFA method with possible adjustments to the algorithm is warranted.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 303 - 303
1 Jul 2011
Colaco H Oussedik S Paton B Haddad F
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Aim: To investigate the relationship between patient psychological characteristics, adherence to rehabilitation physiotherapy and outcome at one year following anterior cruciate ligament reconstruction.

Methods: 75 consecutive patients undergoing ACL reconstruction by a single experienced surgeon received a pre-operative psychological assessment comprising of five questionnaires; Athletic Identity Measurement Scale (AIMS), Recovery Locus of Control Scale (RLCS), Self-Motivation Inventory (SMI), Hospital Anxiety and Depression Scale (HADS), and Short Form Social Support Questionnaire (SSQ6). Four functional questionnaires were completed pre-operatively by the patient; Subjective Knee Evaluation Form (IKDC 2000), Tegner Activity Scale (TAS), Lysholm Score (LS), and Lower Extremity Functional Score (LEFS). LEFS is a simple, sensitive subjective assessment tool which is sensitive to change. Final outcome was assessed by repeating the functional questionnaires at 1-year post-operatively following rehabilitation. Rehabilitation adherence was measured using the Sport Injury Rehabilitation Adherence Scale (SIRAS) and physiotherapy appointment attendance.

Results: The data were analysed using regression analysis (n=57). Self motivation score (R2= 0.142), a higher athletic identity (R2= 0.067), good social support (R2=0.170) and an internal locus of control or high self efficacy (R2=0.111) were all found to be positive predictors of final outcome. Poor self motivation and an external locus of control are associated with less successful final outcome.

Discussion and Conclusion: Self motivation and self efficacy are positive predictors of final outcome after ACL reconstruction. These aspects may be reinforced during rehabilitation. Patients with an external locus of control and poor self-motivation can be identified and their pre- and post-operative management may be adapted to achieve optimal outcome.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 18 - 18
1 Jan 2011
Konan S Kalia P Oussedik S Dodd M Coathup M Haddad F Blunn G
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We investigated the hypothesis that autologous bone marrow stromal cells (BMSC) sprayed on the surface of acetabular cups would improve bone formation and bone implant contact.

Total hip replacements were implanted in 11 sheep, randomly assigned to receive either acetabular implants sprayed with autologous BMSCs suspended in fibrin (study group) or fibrin only (control group). Sheep were sacrificed after six months and the acetabulum with the implant was retrieved and prepared for undcalcified histology. Implant bone contact in both groups was compared, by microscopically noting the presence or absence of new bone or fibrous tissue along the implant at 35 consecutive points (every 1000 μm). The observers undertaking the histological analysis were blinded.

Significantly increased bone implant contact was noted in the BMSC treated group 30.71% ± 2.95 compared to the control group 5.14% ± 1.67 (p = 0.014). The mean thickness of fibrous tissue in contact with the implant was greater at the periphery 887.21mm ± 158.89 and the dome 902.45mm ± 80.67 of the implant in the control group compared to the BMSC treated group (327.49mm ± 20.38 at the periphery and 739.1 mm ±173.72 at the centre). Conversely direct bone contact with the implant surface was significantly greater around the cups with stem cells.

BMSC sprayed on surface of implants improves bone implant contact. Spraying acetabular cups using stem cells could be used in humans where acetabular bone contact is compromised such as in revision procedures.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 414 - 414
1 Jul 2010
Colaço H Oussedik S Paton B Haddad F
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Introduction: The aim of this study is to investigate the relationship between patient psychological characteristics, adherence to rehabilitation physiotherapy and outcome at one year following anterior cruciate ligament reconstruction.

Methods: A group of 57 patients undergoing ACL reconstruction received a pre-operative psychological assessment comprising of five questionnaires; Athletic Identity Measurement Scale (AIMS), Recovery Locus of Control Scale (RLCS), Self-Motivation Inventory (SMI), Hospital Anxiety and Depression Scale (HADS), and Short Form Social Support Questionnaire (SSQ6). Four functional questionnaires were completed pre-operatively by the patient; Subjective Knee Evaluation Form (IKDC 2000), Tegner Activity Scale (TAS), Lysholm Score (LS), and Lower Extremity Functional Score (LEFS). Final outcome was assessed by repeating the functional questionnaires at 1-year post-operatively following rehabilitation. Anterior displacement of the tibia was recorded using a KT1000 arthrometer pre-operatively and at 1 year postoperatively. Adherence to rehabilitation was recorded using the Sport Injury Rehabilitation Adherence Scale (SIRAS) and attendance to physiotherapy appointments.

Results: The data were analysed using regression analysis. Self motivation, a higher athletic identity, good social support and an internal locus of control are all positive predictors of final outcome. Poor self motivation and an external locus of control are associated with less successful final outcome. Rehabilitation adherence is also a positive predictor of final outcome, although psychological factors were not found to be predictive of adherence to rehabilitation.

Discussion and Conclusion: Self motivation and an internal locus of control are positive predictors of adherence to physiotherapy and final outcome. These aspects can be reinforced during rehabilitation. Patients with an external locus of control and poor self-motivation can be identified and their pre- and post-operative management adapted to achieve optimal outcome.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 303 - 303
1 May 2010
Konan S Kalia P Oussedik S Coauthup M Dodd M Haddad F Blunn G
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Despite advances in total hip arthroplasty, failure of acetabular cup remains a concern. The role of bone marrow stromal cells (BMSCs) to aid osseointegration of orthopaedic implants have been recently studied. We investigated the hypothesis that autologous BMSCs sprayed on the surface of acetabular cups would improve bone formation and bone implant contact.

Total hip replacements were implanted in 11 sheep, randomly assigned to receive either acetabular implants sprayed with autologous BMSCs suspended in fibrin (study group) or fibrin only (control group). Sheep were sacrificed after six months and the acetabulum with the implant was retrieved and prepared for undecalcified histology. Implant bone contact in both groups was compared microscopically, by noting the presence or absence of new bone or fibrous tissue along the implant at 35 consecutive points (every 1000 μm). The observers undertaking the histological analysis were blinded.

Significantly increased bone implant contact was noted in the BMSC treated group 30.71% ± 2.95 compared to the control group 5.14% ± 1.67 (p = 0.014). The mean thickness of fibrous tissue in contact with the implant was greater at the periphery 887.21mm ± 158.89 and the dome 902.45mm ± 80.67 of the implant in the control group compared to the BMSC treated group (327.49mm ± 20.38 at the periphery and 739.1 mm ± 173.72 at the centre). Conversely, direct bone contact with the implant surface was significantly greater around the cups with BMSCs.

Our data demonstrate that BMSC sprayed on surface of acetabular implants improves bone implant contact. Spraying acetabular cups using stem cells could be used in humans where acetabular bone contact is compromised such as in revision procedures.


The Journal of Bone & Joint Surgery British Volume
Vol. 91-B, Issue 9 | Pages 1125 - 1126
1 Sep 2009
Oussedik S Haddad F

Recent publication of reports showing high revision rates for hip and knee replacements carried out in Independent Sector Treatment Centres (ISTCs) has raised doubts regarding their ability to provide high quality healthcare. The high revision rates also create a financial burden to the NHS. The poor quality of data collected at ISTCs makes their performance difficult to evaluate. Funds may be better spent improving existing NHS facilities rather than establishing parallel ISTCs.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 288 - 288
1 May 2009
Kalia P Oussedik S Konan S Dodd M Coathup M Blunn G
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Introduction: Aseptic loosening at the bone-implant interface of THA acetabular components is a significant cause of implant failure. This loosening has been attributed either to wear particle-induced osteolysis or to the effects of joint fluid-pressure. It may be possible to prevent the loosening of implants by improving fixation between the bone and implant, or promoting the growth of a biological bony seal, in order to prevent the influx of wear particles or pressurized joint fluid. Additionally in revision implants it is important to promote osseointegration in situations where bone stock may be limited. The hypothesis of this study was spraying autologous BMSCs in fibrin glue onto the surface of HA-coated acetabular components would increase bone formation around the implant and improve bone-implant contact.

Materials and Methods: Bone marrow was aspirated from the iliac crest of six goats, and BMSCs isolated and expanded in vitro. 10 x 10e6 BMSCs were suspended in reconstituted thrombin pre-operatively. A standard posterior approach was used. The acetabular shell was then coated with 2 ml of fibrin glue, with (n=6) or without 10 x 10e6 autologous BMSCs (n=6), and the acetabular component impacted into position. Antibiotic and analgesic prophylaxes were carried out. All animals were weight bearing within 48 hours post-operatively. Walking and ground reaction forces were assessed pre-operatively, as well as 6 and 12 weeks post-operatively. Results were expressed as a percentage of force transmitted through the right leg versus the left leg. After 12 weeks, the acetabulae were retrieved, and processed for histology. The percentage of new bone around the cups was measured within 5 radial zones, using image analysis. Bone-implant contact was also analysed between the new bone and implant surface. Mann Whitney U test was used to show statistical significance.

Results: New bone formation in Zone 5 showed a significant increase in the BMSC group (71.97±10.91%), when compared to the controls (23.85±15.13%, p=0.028). The other zones did not show a significant difference. Overall new bone growth in the BMSC group was 30% greater than the control group (71.42±8.97% and 54.22±16.56%, respectively, p=0.58). Bone-implant contact was significantly improved in the BMSC group (20.03±4.64%), in contrast to the control group (13.71±8.32%, p=0.027). With regards to the force plate analysis, there was no significant difference in loading between groups at both 6 weeks (Controls-79.74±3.63%, BMSCs-59.39±9.33%, p=0.086) and 12 weeks (Controls-86.0%±2.85%, BMSCs-62.33±5.12%, p=0.055).

Discussion and Conclusions: In this study, overall bone growth was greater when cups were treated with BMSCs. Bone-implant contact was significantly improved as well. This study has clinical applications, as using MSCs in fibrin glue promotes a bony seal in contact with the implant which may prevent the migration of particles, or joint fluid, decreasing the likelihood of aseptic loosening of THAs, and improving their longevity. Also, this technique may improve fixation in situations where bone stock is reduced.