Aims. Osteoarticular reconstruction of the distal femur in childhood has the advantage of preserving the tibial physis. However, due to the small size of the distal femur, matching the host bone with an osteoarticular allograft is challenging. In this study, we compared the outcomes and complications of a resurfaced allograft-prosthesis composite (rAPC) with those of an osteoarticular allograft to reconstruct the distal femur in children. Methods. A retrospective analysis of 33 skeletally immature children with a malignant tumour of the distal femur, who underwent resection and reconstruction with a rAPC (n = 15) or osteoarticular allograft (n = 18), was conducted. The median age of the patients was ten years (interquartile range (IQR) 9 to 11) in the osteoarticular allograft group and nine years (IQR 8 to 10) in the rAPC group (p = 0.781). The median follow-up of the patients was seven years (IQR 4 to 8) in the osteoarticular allograft group and six years (IQR 3 to 7) in the rAPC group (p = 0.483). Limb function was evaluated using the Musculoskeletal Tumor Society (MSTS) score. Results. At final follow-up, the knee was unstable in 9/18 patients (50%) in the osteoarticular allograft group and 2/15 patients (13%) in the rAPC group (p = 0.026). The median range of motion (ROM) of the knee was 117° (IQR 115° to 120°) in the osteoarticular allograft group and 100° (IQR 95° to 105°) in the rAPC group (p < 0.001). The median MSTS score was 25 (IQR 23 to 26) in the osteoarticular allograft group and 28 (IQR 26 to 29) in the rAPC group (p = 0.007). Osteoarthritic change was detected in 11/18 patients (61%) in the osteoarticular allograft group and in 4/15 (26%) patients in the rAPC group (p = 0.048). Conclusion. In our series, a resurfaced allograft-prosthesis composite provided better knee stability and function, with a lower rate of osteoarthritis; an osteoarticular allograft was associated with better knee ROM. Cite this article: Bone Joint J 2022;104-B(10):1174–1179

Aims. Using 90% of final height as a benchmark, we sought to develop a quick, quantitative and reproducible method of estimating skeletal maturity based on topographical changes in the distal femoral physis. Patients and Methods. Serial radiographs of the distal femoral physis three years prior to, during, and two years following the chronological age associated with 90% of final height were analyzed in 81 healthy children. The distance from the tip of the central peak of the distal femoral physis to a line drawn across the physis was normalized to the physeal width. Results. A total of 389 radiographs of the distal femur with corresponding Greulich and Pyle bone ages and known chronological ages were measured. Children reached 90% of final height at a mean age of 11.3 years (. sd. 0.8) for girls and 13.2 years (. sd. 0.6) for boys. Linear regression analysis showed higher correlation coefficent in predicting the true age at 90% of final height using chronological age + gender + central peak value (R. 2 . = 0.900) than chronological age + gender (R. 2.  = 0.879) and Greulich and Pyle bone age + gender (R. 2.  = 0.878). Conclusion. Chronological age + gender + central peak value provides more accurate prediction of 90% of final height compared with chronological age + gender and Greulich and Pyle bone age + gender. Cite this article: Bone Joint J 2018;100-B:1106–11

Aims. Dual plating of distal femoral fractures with medial and lateral implants has been performed to improve construct mechanics and alignment, in cases where isolated lateral plating would be insufficient. This may potentially compromise vascularity, paradoxically impairing healing. This study investigates effects of single versus dual plating on distal femoral vascularity. Methods. A total of eight cadaveric lower limb pairs were arbitrarily assigned to either 1) isolated lateral plating, or 2) lateral and medial plating of the distal femur, with four specimens per group. Contralateral limbs served as matched controls. Pre- and post-contrast MRI was performed to quantify signal intensity enhancement in the distal femur. Further evaluation of intraosseous vascularity was done with barium sulphate infusion with CT scan imaging. Specimens were then injected with latex medium and dissection was completed to assess extraosseous vasculature. Results. Quantitative MRI revealed a mean reduction of 21.2% (SD 1.3%) of arterial contribution in the lateral plating group and 25.4% (SD 3.2%) in the dual plating group (p = 0.051); representing a mean decrease in arterial contribution of 4.2%. The only significant difference found between both experimental groups was regionally, at the lateral aspect of the distal femur with a mean drop in arterial contribution in the lateral plating group of 18.9% (SD 2.6%) versus 24.0% (SD 3.2%) in the dual plating group (p = 0.048), representing a mean decrease in arterial contribution of 5.1%. Gross dissection revealed complete destruction of periosteal vessels underneath either medial or lateral plates in both groups. The network of genicular branches contributing to the posterior and distal femoral condyles was preserved in all specimens. A medial vascular pedicle was found dividing from the superficial femoral artery at a mean 12.7 cm (SD 1.7) proximal to the medial epicondyle and was undisrupted in the dual plating group. Conclusion. Lateral locking-plate application resulted in mean 21.2% reduction in distal femur vascularity. Addition of medial plates did not further markedly decrease vascularity. As such, the majority of the vascular insult occurred with lateral plating alone. Supplemental medially based fixation did not lead to marked devascularization of the distal femur, and should therefore be considered in the setting of comminution and poor bone stock in distal femoral fractures. Further clinical research is required to confirm the results of this study. Cite this article: Bone Joint J 2020;102-B(4):530–538

Dual plating of the medial and lateral distal femur has been proposed to reduce angular malunion and hardware failure secondary to delayed union or nonunion. This strategy improves the strength and alignment of the construct, but it may compromise the vascularity of the distal femur paradoxically impairing healing. This study investigates the effect of dual plating versus single plating on the perfusion of the distal femur. Ten matched pairs of fresh-frozen cadaveric lower extremities were assigned to either isolated lateral plating or dual plating of a single limb. The contralateral lower extremity was used as a matched control. A distal femoral locking plate was applied to the lateral side of ten legs using a standard sub-vastus approach. Five femurs had an additional 3.5mm reconstruction plate applied to the medial aspect of the distal femur using a medial sub-vastus approach. The superficial femoral artery and the profunda femoris were cannulated at the level of the femoral head. Gadolinium MRI contrast solution (3:1 gadolinium to saline ration) was injected through the arterial cannula. High resolution fat-suppressed 3D gradient echo sequences were completed both with and without gadolinium contrast. Intra-osseous contributions were quantified within a standardized region of interest (ROI) using customized IDL 6.4 software (Exelis, Boulder, CO). Perfusion of the distal femur was assessed in six different zones. The signal intensity on MRI was then quantified in the distal femur and comparison was made between the experimental plated limb and the contralateral, control limb. Following completion of the MRI protocol, the specimens were injected with latex medium and the extra-osseous vasculature was dissected. Quantitative MRI revealed that application of the lateral distal femoral locking plate reduced the perfusion of the distal femur by 21.7%. Within the dual plating group there was a reduction in perfusion by 24%. There was no significant difference in the perfusion between the isolated lateral plate and the dual plating groups. There were no regional differences in perfusion between the epiphyseal, metaphyseal or meta-diaphyseal regions. Specimen dissection in both plating groups revealed complete destruction of any periosteal vessels that ran underneath either the medial or lateral plates. Multiple small vessels enter the posterior condyles off both superior medial and lateral geniculate arteries and were preserved in all specimens. Furthermore, there was retrograde flow to the distal most aspect of the condyles medially and laterally via the inferior geniculate arteries. The medial vascular pedicle was proximal to the medial plate in all the dual plated specimens and was not disrupted by the medial sub-vastus approach in any specimens. Fixation of the distal femur via a lateral sub-vastus approach and application of a lateral locking plate results in a 21% reduction in perfusion to the distal femur. The addition of a medial 3.5mm reconstruction plate does not significantly compromise the vascularity of the distal femur. The majority of the vascular insult secondary to open reduction, internal fixation of the distal femur occurs with application of the lateral locking plate

Aims. The epiphyseal approach to a chondroblastoma of the intercondylar notch of a child’s distal femur does not provide adequate exposure, thereby necessitating the removal of a substantial amount of unaffected bone to expose the lesion. In this study, we compared the functional outcomes, local recurrence, and surgical complications of treating a chondroblastoma of the distal femoral epiphysis by either an intercondylar or an epiphyseal approach. Methods. A total of 30 children with a chondroblastoma of the distal femur who had been treated by intraregional curettage and bone grafting were retrospectively reviewed. An intercondylar approach was used in 16 patients (group A) and an epiphyseal approach in 14 (group B). Limb function was assessed using the Musculoskeletal Tumor Society (MSTS) scoring system and Sailhan’s functional criteria. Results. At final follow-up, the mean MSTS score was 29.1 (SD 0.9) in group A and 26.7 (SD 1.5) in group B (p = 0.006). According to Sailhan’s criteria, the knee function was good and fair in 14 (87.5%) and two (12.5%) patients of group A, and eight (57.1%) and six (42.9%) patients of group B, respectively (p = 0.062). The lesion had recurred in one patient (6.2%) in group A and four patients (28.6%) in group B. Limb shortening > 1 cm was recorded in one patient (6.2%) from group A and six patients (42.8%) from group B. Joint degeneration was noted in one patient from group A and three patients from group B. Conclusion. An intercondylar approach to a chondroblastoma of the middle two-quarters of the distal femoral epiphysis results in better outcomes than a medial or lateral epiphyseal approach: specifically, better limb function, a lower rate of recurrence, and a lower rate of physeal damage and joint degeneration. Cite this article: Bone Joint J 2024;106-B(2):195–202

Introduction. The use of vascularised fibula grafts is an accepted method for reconstructing the distal femur following resection of malignant childhood tumours. Limitations relate to the mismatch of the cross-sectional area of the transplanted fibula graft and thel ocal bone, instability of the construct and union difficulties. We present midterm results of a unique staged technique—an immediate defect reconstruction using a double-barrel vascularised fibula graft set in in A-frame configuration and a subsequent intramedullary femoral lengthening. Materials & Methods. We retrospectively included 10 patients (mean age 10 y)with an osteosarcoma of the distal femur, who were treated ac-cording to the above-mentioned surgical technique. All patients were evaluated with regards to consolidation of the transplanted grafts, hypertrophy at the graft-host junctions, leg length discrepancies, lengthening indices, complications as well as functional outcome. Results. The mean defect size after tumour resection was 14.5 cm, the mean length of the harvested fibula graft 22 cm, resulting in a mean (acute) shortening of 4.7 cm (in 8 patients). Consolidation was achieved in all cases, 4 patients required supplementary bone grafting. Hypertrophy at the graft-host junctions was observed in78% of the evaluable junctions. In total 11 intramedullary lengthening procedures in 9 patients had been performed at the last follow up. The mean Muskuloskeletal Society Rating Scale(MSTS) score of the evaluable 9 patients was 85% (57% to 100%)with good or excellent results in 7 patients. Conclusions. A-frame vascularised fibula reconstructions showed encouraging results with respect to defect reconstruction, length as well as function and should therefore be considered a valuable option for reconstruction of the distal femur after osteosarcoma resection. The surgical implementation is demanding though, which is emphasized by the considerable high number of com-plications requiring surgical intervention, even though most were not serious

Aims. Fractures of the distal femur are an important cause of morbidity. Their optimal management remains controversial. Contemporary implants include angular-stable anatomical locking plates and locked intramedullary nails (IMNs). We compared the long-term patient-reported functional outcome of fixation of fractures of the distal femur using these two methods of treatment. Patients and Methods. A total of 297 patients were retrospectively identified from a State-wide trauma registry in Australia: 195 had been treated with a locking plate and 102 with an IMN. Baseline characteristics of the patients and their fractures were recorded. Health-related quality-of-life, functional and radiographic outcomes were compared using mixed effects regression models at six months and one year. Results. There was a clinically relevant and significant difference in quality-of-life at six months in favour of fixation with an IMN (mean difference in EuroQol-5 Dimensions Score (EQ-5D) = 0.12; 95% CI 0.02 to 0.22; p = 0.025). There was weak evidence that this trend continued to one year (mean difference EQ-5D = 0.09; 95% CI -0.01 to 0.19; p = 0.073). There was a significant although very small reduction in angular deformity using an IMN (mean difference -1.02; 95% CI -1.99 to -0.06; p = 0.073). There was no evidence that there was a difference in any other outcomes at any time point. Take home message: IMN may be a superior treatment compared with anatomical locking plates for fractures of the distal femur. These findings are concordant with other data from pilot randomised studies which favour treatment of these fractures with an IMN. This study strongly supports the need for a definitive randomised trial. Cite this article: Bone Joint J 2016;98-B:846–50

Analysis of the morphology of the distal femur, and by extension of the femoral components in total knee arthroplasty (TKA), has largely been related to the aspect ratio, which represents the width of the femur. Little is known about variations in trapezoidicity (i.e. whether the femur is more rectangular or more trapezoidal). This study aimed to quantify additional morphological characteristics of the distal femur and identify anatomical features associated with higher risks of over- or under-sizing of components in TKA. We analysed the shape of 114 arthritic knees at the time of primary TKA using the pre- operative CT scans. The aspect ratio and trapezoidicity ratio were quantified, and the post- operative prosthetic overhang was calculated. We compared the morphological characteristics with those of 12 TKA models. There was significant variation in both the aspect ratio and trapezoidicity ratio between individuals. Femoral trapezoidicity was mostly due to an inward curve of the medial cortex. Overhang was correlated with the aspect ratio (with a greater chance of overhang in narrow femurs), trapezoidicity ratio (with a greater chance in trapezoidal femurs), and the tibio- femoral angle (with a greater chance in valgus knees). This study shows that rectangular/trapezoidal variability of the distal femur cannot be ignored. Most of the femoral components which were tested appeared to be excessively rectangular when compared with the bony contours of the distal femur. These findings suggest that the design of TKA should be more concerned with matching the trapezoidal/ rectangular shape of the native femur

Introduction. The human body is a complex and continually adapting organism. It is theorised that the morphology of the proximal femur is closely related to that of the distal femur. Patients that have abnormal anatomy in the proximal femur, such as a high femoral neck anteversion angle, may have abnormal anatomy in the distal femur to overcome proximal differences. This phenomenon is of key interest when performing Total Hip Replacement (THR) or Total Knee Replacement (TKR) surgery. The current design and placement of existing hip and knee implants does not account for any correlation between the anatomical parameters of the proximal and distal femur, where bone anatomy may have adapted to compromise for abnormalities. A preliminary study of 21 patients has been carried out to assess the relationship between the proximal and distal femur. The difficulties in defining and measuring key anatomical parameters on the femur have been widely discussed in the literature [1] due to its complex three dimensional geometry. Using CT scans of healthy octogenarians, it was possible to mark key anatomical landmarks which could be used to define various anatomical axes throughout the femur. Correlation analyses could then be carried out on these parameters to assess the relationship between proximal and distal femur morphology. Methods. Each femur was initially realigned along the mechanical axis (MA); defined by joining the centre of the femoral head (FHC) to the centre of the intercondylar notch (INC) [2]. All anatomical landmarks were then identified using the Materialise Mimics v12 software (Figure 1 and 2) and exported into Microsoft Excel for analysis. Key anatomical parameters which were derived from these landmarks included the femoral neck axis (FNA), femoral neck anteversion angle (FNAA) [1–4], condylar twist angle, clinical transepicondylar axis (TEA), trochlea sulcus angle and medial and lateral trochlea twist. A correlation analysis was carried out on SPSS Statistics v20 (IBM) to assess the relationship between proximal and distal anatomical parameters. Results. The correlation analysis displayed a positive linear correlation between the FNAA and the clinical TEA (adjusted R squared = 0.471, p < 0.001) indicating that an abnormally high FNAA is correlated with a higher TEA angle (Figure 3). No strong relationship was found between the FNAA and the additional distal parameters compared, in particular there was no trend between the FNAA and the geometry of the trochlea as measured by the sulcus angle and trochlea twist. Discussion. The morphology of the distal femur seems to be at least partially correlated with the proximal femur and the relationship should be studied further to assess any potential effect on THA and TKA surgery. An extension of this study should assess an increased patient sample size and further anatomical parameters

Osteomyelitis is an inflammatory condition accompanied by the destruction of bone and caused by an infecting microorganism. Open contaminated fractures can lead to the development of osteomyelitis of the fractured bone in 3-25% of cases, depending on fracture type, degree of soft-tissue injury, degree of microbial contamination, and whether systemic and/or local antimicrobial therapies have been administered. Untreated, infection will ultimately lead to non-union, chronic osteomyelitis, or amputation. We report a case series of 10 patients that presented with post-operative infected non-union of the distal femur with or without prior surgery. The cases were performed at Padmashree Dr. D. Y. Patil Hospital, Nerul, Navi Mumbai, India. All the patients’ consents were taken for the study which was carried out in accordance with the Helsinki Declaration. The methodology involved patients undergoing a two-stage procedure in case of no prior implant or a three-stage procedure in case of a previous implant. Firstly, debridement and implant removal were done. The second was a definitive procedure in form of knee arthrodesis with ring fixator and finally followed by limb lengthening surgery. Arthrodesis was planned in view of infection, non-union, severe arthritic, subluxated knee, stiff knee, non-salvage knee joint, and financial constraints. After all the patients demonstrated wound healing in 3 months along with good radiographic osteogenesis at the knee arthrodesis site, limb lengthening surgeries by tibial osteotomy were done to overcome the limb length discrepancy. Distraction was started and followed up for 5 months. All 10 patients showed results with sound knee arthrodesis and good osteogenesis at the osteotomy site followed by achieving the limb length just 1-inch short from the normal side to achieve ground clearance while walking. Our case series is unique and distinctive as it shows that when patients with infected nonunion of distal femur come with the stiff and non-salvage knee with severe arthritic changes and financial constraints, we should consider knee arthrodesis with Ilizarov ring fixator followed by limb lengthening surgery

Introduction: morphological analysis of the general shape of the bones and of their particular variations according to the patient age, gender and pathology is an important step to improve the orthopedic management. We aimed to performed a gender specific analysis of the bi and tridimensional anatomy of the distal femur in vitro and in vivo. Materials and Methods: in vitro data were obtained from CT-scan performed on 92 dry men femurs and 52 dry women femurs. Using a manual contouring method and a segmentation method, tridimensional reconstructions were obtained and according to two different algorithms, the regions of discrepancies between men and women were determined. An automatic calculation of 59 defined measurements was then performed. In vivo data providing from 59 CT-scans of men femur and 73 CT-scan of women femurs were acquired. Standardized bidimensional measurements at the level of the trochlear cut were performed. Results: in vivo, statistically significant differences were observed for the: medio-lateral distance (M-Ld women=7.4±0.4cm vs M-Ld men=8.4±0.5cm; p< 0.0001), anteroposterior distance (A-Pd women=5.9±0,4cm vs A-Pd men= 6.4±0.4cm; p< 0.0001) and for the ratio anterior-posterior distance/medio-lateral distance (p< 0.0001). The trochlear groove angle was comparable in the two groups. In vitro, the tridimensional shape of the distal femur was more trapezoidal in women than in men. Medio-lateral distances were also statistically greater in men than in women (p< 0.01), the ratio anterior-posterior distance/medio-lateral distance was also statistically greater in men than in women (p< 0.01) and the Q angle more open in women than in men (p< 0.01). Discussion: Three types of differences between men and women were observed in this gender specific evaluation of the distal femur anatomy. First, for a same anteroposterior distance, the medio-lateral distance was smaller in women. Second, the global shape of the distal femur was more trapezoidal in women and third the Q angle was more open in women. This gender specific anatomy should be clinically considered when performing total knee arthroplasty in women and gender specific implants may be required

Background. Most of contemporary total knee systems address on improving of range of motion and bearing materials. Although new total knee designs in most systems accommodated the knee morphology according to gender differences, reestablishing of the same anterior offset of the distal femur during total knee arthroplasty (TKA) has not been well addressed. Furthermore, in most total knee systems, the anterior offset of the femoral component is constant regardless of the increment of the femoral size. We hypothesized that change of the anterior offset of the distal femur during TKA might affect the quadriceps strength and immediate clinical outcomes which may result in improved design of the future femoral component. Purpose. To evaluate the peak quadriceps strength and immediate clinical outcomes related to the change of anterior offset of the distal femur during TKA. Materials & Methods. We prospectively evaluated 75 patients (75 knees) who had primary osteoarthritis and underwent an uncomplicated TKA. A measured-resection technique of surgery using a single design of semi-constrained posterior-stabilized prosthesis with patellar resurfacing was used in all knees. In every TKA, the patellar resection was quantified in order to provide a similar thickness of the patellar composite to the original patellar thickness. A uniform perioperative protocol was applied. The mean thickness from the medial and lateral sides of the resected anterior femur were evaluated and compared with the mean thickness of the anterior part of the femoral component. The peak quadriceps strength and peak hip flexor strength was evaluated before surgery, and then at 2 weeks, 6 weeks and 3 months, postoperatively, using a digital dynamometer. The Difference of thickness between the resected anterior femoral bone and the anterior femoral component was defined as the change of the anterior offset of the distal femur. Clinical outcomes, including Knee Society Scores (KSS) and Western Ontario and McMaster University Arthritis Index (WOMAC) scores at 2 weeks, 6 weeks and 12 weeks were evaluated in relation of muscle strengths. Results. Patients were divided in 2 groups according to the change of the anterior offset of the distal femur during TKA. Thirty knees (group A) had similar or increased anterior offset of the distal femur and 45 knees (group B) had decreased anterior offset of the distal femur. The mean thickness of the resected anterior femoral bones in group A and B were 4.8 mm and 9.7 mm, respectively. The mean changes of anterior offset in group A and B were (+)0.7 mm and (−)4.2 mm with statistical difference (p, 0.01). There were no differences in patient's demographic data including age, sex, and body mass index (BMI). Preoperatively, both groups had similar mean peak quadriceps strength (108.04 N vs.115.52 N, p, 0.191) and mean peak hip flexor strength (105.98 N vs.108.05 N, p.0.745). At 2-week follow-up (FU), group A had significantly better peak quadriceps strength (111.53 N vs. 99.75 N, p, 0.03) and improve of total WOMAC score (32.4 points vs. 27.4 points, p, 0.03) than those of group B, The improved WOMAC score was statistical significant in subgroup of function (16.7 points vs. 12.7, p, 0.04) However, the peak hip flexor strength, KSS clinical scores and function scores were not different. At 6-week FU 12-week FU, there were no differences in all measuring parameters. Discussion and Conclusion. Biomechanical study has shown that the anterior offset of the distal femur provides role as a lever arm for a proper quadriceps function. Therefore, with maintaining of the patellar thickness during TKA in individual patient, a constant thickness of the anterior offset of the femoral component regardless of size may result in change of the anterior offset of the distal femur and may affect the function of quadriceps. The present study demonstrated that, at 2 weeks postoperatively, patients who had increased anterior offset of the distal femur could significantly gain better peak quadriceps strength and improved WOMAC function score than those who did not. In addition, change of anterior offset of the distal femur had no relation with the peak hip flexor strength. A mean 4.2-mm decreasing of anterior offset of the distal femur during TKA caused a shorter lever arm to the quadriceps and resulted in reducing the peak quadriceps strength with no gross effect on hip flexor strength. Although peak quadriceps strength in patients who had increased anterior offset of distal femur correlated with improved WOMAC function score, this marginal statistical significance provided a very short time for advantages. As there was a similar or slightly increased of anterior femoral offset in Group A, the anterior overstuff should be very minimal. At 6 weeks and 12 weeks after surgery, we found that investigated parameters, as well as clinical outcomes, were not different in both groups. We concluded that the change of femoral offset during TKA provided a short effect on quadriceps strength and clinical outcomes for few weeks which had no clinical impact on the drive to improve the prosthetic design of the femoral component which has a constant thickness of the anterior offset

Purpose. The purpose of this study is to analyse regional differences in the microstructural and mechanical properties of the distal femur depending on osteoarthritic changes using micro-images based on finite element analysis. Materials and Methods. Distal femur specimens were obtained from ten donors composed of 10 women with OA (mean age of 65 years, ranging from 53 to 79). As controls, the normal distal femur was sampled from age and gender matched donors consisting of 10 women(mean age of 67 years, ranging from 58 to 81). The areas of interest were six regions of the condyles of the femur(Lateral-Anterior, Middle, Posterior; Medial=Anterior, Middle, Posterior). A total of 20 specimens were scanned using the micro-CT system. Micro-CT images were converted to micro-finite element model using the mesh technique, and micro-finite element analysis was then performed for assessment of the mechanical properties. Results. Trabecular bones from the distal femur in control and OA groups exhibited different microstructural and mechanical properties in the same region. BV/TV, Tb.N, Tb.S and Yield strength were different between LA and MMsignificantly (p=0.005). In control group, the lateral anterior region of the distal femur reflected subchondral trabecular remodeling, while in advanced OA group, the medial middle region showed prominent changes in the microstructural and mechanical properties. Conclusion. The authors concluded that with aging and the progress of primary OA, changes of patello-femoral reaction force induced subchondral trabecular changes of the anterolateral region initially, and then progressed to the medial middle and posterior region in advanced OA

Purpose. Analysis of the morphology of the distal femur, and by extension of the femoral components in total knee arthroplasty (TKA), has been related to the aspect ratio, which represents the width of the femur. Little is known about variations in trapezoidicity (i.e whether the femur is more rectangular or more trapezoidal). This study aimed to quantify additional morphological characteristics of the distal femur and identify anatomical features associated with higher risks of over- or under-sizing of components in TKA. Method. We analyzed the shape of 114 arthritic knees at the time of primary TKA using the pre-operative CT scans. The maximum AP dimension was measured. The mediolateral dimensions were measured on the theoretical distal resection slice at three levels: the posterior region (MLP), the central region (MLC) and the anterior region (MLA) (Fig 1). The ‘aspect’ ratio (MLC/AP) ratio quantified how wide or narrow the shape is. The ‘trapezoidicity’ ratio (MLP/MLA) ratio quantified how rectangular or trapezoidal the shape is. We also quantified the medial and lateral ‘narrowing angles’ in the anterior and central zones (α and β) (Fig 2). The post-operative prosthetic overhang was calculated from CT-scan. We compared the morphological characteristics with those of twelve TKA models scanned using a three-dimensional optical scanning machine (ATOS II, GOM mbH, Braunschweig, Germany) and its photogrammetric analysis software (TRITOP, GOM mbH, Braunschweig, Germany). Results. There were significant variations in both the aspect ratio (1.16±0.07; range 0.98–1.31) and the trapezoidicity ratio (1.21±0.08; range 1.06– 1.46). Femoral trapezoidicity was mostly due to an inward curve of the medial cortex. The multivariate analysis indicated that prosthetic overhang was correlated to the ‘aspect ratio’ (more overhang in narrow femurs, p=0.002), to the ‘trapezoidicity ratio’ (more overhang in trapezoidal femurs, p=0.002), and to the Tibio Femoral Angle (more overhang in valgus knees, p=0.035). The geometries of the twelve specimen components can be compared directly with the morphological findings of this study. Some components had excessively low trapezoidicity ratios (i.e. were too rectangular) such as DePuy LCS and Stryker Scorpio. Other designs had trapezoidicity ratios closer to anatomic values such as Zimmer Nexgen, Zimmer Persona, DePuy Attune and Smith and Nephew Journey (Fig 3). Several components had excessively low anterior lateral narrowing angle (αL) such as DePuy LCS, Stryker Scorpio. All had insufficiently low medial narrowing angles. Conclusion. This study shows that rectangular/trapezoidal variability of the distal femur cannot be ignored. Most of the femoral components, which were tested appeared to be excessively rectangular when compared with the bony contours of the distal femur. These findings suggest that the design of TKA should be more concerned with matching the trapezoidal/rectangular shape of the native femur

Objective. In a cruciate retaining total knee arthroplasty (CR-TKA) for patients with flexion contracture, to ensure that an extension gap is of sufficient size to install an implant, the amount of distal femur bone resection needed is frequently larger in a patient with knee flexion contracture than in one without contracture. In this study, we compared the distal femur bone resection amount, the component-secured extension gap margin value, and the range of motion at 6 months after surgery between patients with knee flexion contracture and those without knee flexion contracture. Method. We examined 51 joints including 27 joints in patients with preoperative extension limitation of less than 5 degrees (the F0 group) and 24 joints in patients with limitation of 15 degrees or larger (up to 33 degrees; the FC group) who underwent CR-TKA with LCS RP (DePuy Synthes) between May 2013 and April 2014. In case with an extension gap 3 mm or smaller than the flexion gap after initial bone resection, we released posterior capsule adequately, trying to minimize the distal femur additional bone resection amount as possible. With installation of a femoral trial, the component gaps were measured using spacer blocks. The measured parameters included the intraoperative bone resection length, gap difference (FG − EG, i.e., difference between the flexion gap [FG] and extension gap [EG]), and range of motion 6 months after surgery. Results. No inter-group difference was found in the length of the distal femur bone initially resected in the medial side of distal femur(F0: 6.7 ± 1.3 mm, FC: 6.1 ± 1.4 mm) and total length of bone resection (= first + additional resection) in the lateral proximal tibia (F0: 10.3 ± 1.9 mm, FC: 10.4 ± 2.1 mm). The length of the additional distal femur bone resected was 0.9 ± 1.3 mm in the F0 and 1.5 ± 1.2 mm in the FC (P = 0.06; Mann-Whitney U). The FG-EG (F0: 0.7 ± 0.9 mm, FC: 0.6 ± 0.8 mm) showed no remarkable inter-group difference. The mean range of motion was changed from −2.3° to −0.6° at extension and from 130.4° to 128.7° at flexion in the F0 and from −19.8° to −2.7° at extension and from 113.7° to 122.3° at flexion in the FC. Conclusions. The amount of distal femur bone resected should not be simply increased because this may elevate the joint line, narrow the flexion range, and cause the joint instability in mid-flexion. The results of this study show that, in CR-TKA for patients with flexion contracture up to 30°, the length of distal femoral bone resection of approximately 1 mm larger than that in patients without contracture may ensure an extension gap of necessary and sufficient length to install an implant

Background:. Septic arthritis following intra-capsular penetration of the knee by external fixation devices is a complication of traction/fixation devices. This study aimed to demonstrate the capsular attachments and reflections of the distal femur to determine safe placements of wires. Methods:. The attachments of the capsule to the distal femur were measured in cadaveric knees. Medially and laterally measurements were expressed as percentages related to the maximal AP diameter of the distal femur. Results:. Mean distance of the anterior attachment was 79.5mm (Range 48.1–120.7mm). The medial capsular reflections were attached an average of 57% back from the anterior edge (Range 41–74%). Laterally the capsular reflections were attached an average of 48% from the anterior reference point (Range 33–57%). Discussion:. Capsular reflections varied. Medially the capsule attachment was up to 74% of diameter of distal femur at the level of the adductor tubercle. Therefore, the insertion of distal femoral traction pins or similar should be placed proximal to the adductor tubercle and no further than 25% of the distance to the anterior cortex. Care is needed to ensure pins do not travel to exit too anteriorly on the lateral side as capsular attachments were found to be up to a distance 48% of the diameter of the femur from anterior reference point

Study Aim. Femoral components used in total knee arthroplasty (TKA) are primarily designed on the basis of kinematics and ease of fixation. This study considers the stress-strain environment in the distal femur due to different implant internal geometry variations (based on current industry standards) using finite element (FE) analyses. Both two and three dimensional models are considered for a range of physiological loading scenarios – from full extension to deep flexion. Issues associated with micro-motion at the bone-implant interface are also considered. Materials and methods. Two (plane strain) and three dimensional finite element analyses were conducted to examine implant micro-motions and stability. The simple 2D models were used to examine the influence of anterior-posterior (AP) flange angle on implant stability. AP slopes of 3°, 7° and 11° were considered with contact between bone and implant interfaces being modeled using the standard coulomb friction model. The direction and region of loading was based on loading experienced at full extension, 90° flexion and 135° flexion. Three main model variations were created for the 3D analyses, the first model represented an intact distal femur, the second a primary implanted distal femur and the third a distal femur implanted with a posterior stabilising implant. Further each of the above 3D model sets were divided into two group, the first used a frictional interface between the bone and implant to characterise the behavior of uncemented implants post TKA and the second group assumed 100% osseointegration had already taken place and focused on examining the subsequent stress/strain environment in the femur with respect to different femoral component geometries relative the intact distal femur model. Results and Discussion. Analyses indicate a trend relating the slope of the anterior-posterior (AP) flange to implant loosening at high flexion angles for uncemented components. Once cemented, this becomes less important. Results from the 3D analyses show that the posterior stabilising implant causes stress concentrations which can lead to bicondylar fatigue fracture. All femoral components cause stress shielding in cancellous bone particularly when they are fully bonded. Investigations into implant micromotion show that revision implants with box sections provided more resistance to micromotion than the pegged primary implants. However for the gait cycle tested the maximum recorded micromotion of both implants was well within acceptable levels for osseointegration to occur

Introduction: Osteoarticular allograft represents a reliable option for distal femur reconstruction. The purpose of this study was to describe the technical details and results of distal femur tumor resection and reconstruction with an osteoarticular allograft. Material and Methods: One hundred and twenty-two patients who received an osteoarticular allograft after distal femur resection were reviewed, with a mean follow-up of 7 years. Key points for successful fixation are allograft selection, absolute stability and satisfactory soft-tissue reconstruction at the time of surgery that allows aggressive rehabilitation. Survival of the allograft was estimated with the Kaplan-Meier method. Functional and radiographic results were documented according to the Musculoskeletal Tumor Society scoring system at the time of the latest follow-up. Results: Three patients were lost to follow and twenty-three patients died for tumor related reasons without allograft failure. In the remaining 96 allografts, eighteen allografts failed due to 7 infections, 7 local recurrences, 1 massive resorption and 3 fractures. Overall allograft survival was 82% +/− 7.6% (+/− 2 SE) at five and ten years. Those patients who preserved the original allograft had an average functional score of 27 points and a mean radiographic score of 89%, which represents a good and excellent functional and radiographic result. Discussion and conclusion: Osteoarticular allograft is a successful procedure for reconstruction of the distal femur. Adequate preoperative planning, careful surgical technique and aggressive rehabilitation lead to excellent function and low complication rate

Introduction. Accurate alignment and sizing of the femoral component in total knee arthroplasty (TKA) is important for stability and functional outcomes. In relation to the shape of the distal femur, it has been reported that the medial-lateral (ML) femur width in women is narrower than that in men for the same antero-posterior (AP) length. In addition, it has been noted that the elevation of the anterior condyle in women is lower than that in men. Therefore, in TKA for women, it is suggested that a medial or lateral overhanging femoral component can cause pain or limit the range of motion (ROM). As a result, a gender-specific implant for women has been developed. However, there are few studies addressing the morphological dimensions of the distal shape of the femur in the Japanese population. The objective of this study was to reveal the appropriateness of using gender-specific implant for Japanese women. Methods. This study was based on 40 women (40 knees) and 40 men (40 knees) who had primary preoperative osteoarthritis of the knee. The average height was 161.2 cm for men and 149.4 cm for women. The average weight was 68.0 kg for men and 58.5 kg for women. These are significantly different. Resection of the distal femur for TKA was simulated with preoperative computed tomography (CT) data. The ML width on the anterior and distal cut surface, the ML width at the surgical epicondylar axis (SEA) level, the maximum AP length at the medial and lateral condyle, and the AP length after resection were measured. These values were compared between men and women, and compatibility with NexGen LPS-Flex and Gender Solution Femur (GSF) (Zimmer, Warsow, Ind) was evaluated. Results. On the anterior cut surface, the average ML width was 54.0 mm for men and 47.0 mm for women. There was a significant difference between them (P<0.01). The aspect ratio (AP/ML) at the SEA level and the resected distal surface was 0.74 and 0.65 for men and 0.76 and 0.70 for women, respectively. There were significant differences between them (P<0.01). Discussion and Conclusion. In general, the aspect ratio of the distal femur in the Japanese population was smaller than that in the Caucasian population. However, the femoral distal shape in women was narrower than that in men for the same AP length in the Japanese population. As the AP size increased, the femoral component in women tended to overhang the ML width. Therefore, the use of a gender-specific implant for women was suggested. In contrast, there were some cases in which the femoral component tended to be undersized compared with the ML width in men. [Fig. 1] For Japanese women, the use of a gender-specific component should be considered. Additionally, there is a need for further investigation of gender-specific components in men

Correct sizing of knee arthroplasty implants avoids problems such as stiffness from too large an implant, or periprosthetic fractures from undersizing. Currently most implants are based on a generic unisex population. Femoral component sizing is therefore based solely on the AP measurement after the distal femoral cut. In order to investigate the differences between the New Zealand population and other populations with reported anthropometrics we studied the anthropometrics of the male and female distal femur. The distal femur of 26 cadaveric knees was resected using standard cutting guides. Using a sizing guide the AP dimension was measured from the posterior condyle to the anterior cortex just proximal to the trochlea (posterior referencing). The ML dimension was measured at the cut surface in the coronal plane of the epicondylar axis. Overall AP measurement had a mean(standard deviation) of 62(±6.7) mm, the ML measurements had a mean (sd.) of 72(±6.6)mm yielding an ML/AP(100) ratio of 117(±11). The male AP mean was 67(±4.5) mm and female AP 57 (±4.4)mm. The male ML was 77 (±4.7)mm and female ML 68 (±4.5)mm. The ML/AP ratio for male was 111(±12) and female was 120 (±10). This pilot study has shown differences between genders in the NZ population even with this small sample size. As this data is important for designers of total knee implants, planning is currently underway to perform measurements intraoperatively from approximately 400 patients undergoing total knee replacement