Despite multiple published reviews, the optimum method of correction and stabilisation of Blount's disease remains controversial. The purpose of this study is to evaluate the clinical and radiological outcomes of acute correction of late-onset tibial vara by percutaneous proximal tibial osteotomy with circular external fixation using two simple rings. This technique was developed to minimise cost in a context of limited resources. This study was conducted between 2016 and 2020. We retrospectively reviewed the clinical notes and radiographs of 30 patients (32tibiae) who had correction of late-onset tibia by proximal tibial osteotomy and Ilizarov external fixator. All cases were followed up to 2 years. The mean proximal tibial angle was 65.7° (±7.8) preoperatively and 89.8° (±1.7) postoperatively. The mean mechanical axis deviation improved from 56.2 (±8.3) preoperatively to 2.8 (±1.6) mm postoperatively. The mean femoral-tibial shaft angle was changed from – 34.3° (±6.7) preoperatively to 5.7° (±2.8) after correction. Complications included overcorrection (9%) and pin tract infection (25%). At final follow up, all patients had full knee range of motion and normal function. All cases progressed to union and there were no cases of recurrence of deformity. This simple procedure provides secure fixation allowing early weight bearing and early return to function. It can be used in the context of health care systems with limited resources. It has a relatively low complication rate. Our results suggest that acute correction and simple circular frame fixation is an excellent treatment choice for cases of late-onset tibia vara, especially in severe deformities

Introduction

The objective of this study is to report the first cases of femoral lengthening in children using Ilizarov fixator.

Aims

The aim of this study was to describe the technique of distraction osteogenesis followed by arthrodesis using internal fixation to manage complex conditions of the ankle, and to present the results of this technique.

Objectives

The purpose of this study was to create a novel ex vivo organ culture model for evaluating the effects of static and dynamic load on cartilage.

Aims

To present our experience of using a combination of intra-articular osteotomy and external fixation to treat different deformities of the knee.

The traditional techniques involving an oblique tunnel or triangular wedge resection to approach a central or mixed-type physeal bar are hindered by poor visualisation of the bar. This may be overcome by a complete transverse osteotomy at the metaphysis near the growth plate or a direct vertical approach to the bar. Ilizarov external fixation using small wires allows firm fixation of the short physis-bearing fragment, and can also correct an associated angular deformity and permit limb lengthening.

We accurately approached and successfully excised ten central- or mixed-type bars; six in the distal femur, two in the proximal tibia and two in the distal tibia, without damaging the uninvolved physis, and corrected the associated angular deformity and leg-length discrepancy. Callus formation was slightly delayed because of periosteal elevation and stretching during resection of the bar. The resultant resection of the bar was satisfactory in seven patients and fair in three as assessed using a by a modified Williamson–Staheli classification.

Cite this article: Bone Joint J 2015;97-B:1726–31.

This review explores recent advances in fixator design and used in contemporary orthopaedic practice including the management of bone loss, complex deformity and severe isolated limb injury.

Infected nonunion of a long bone continues to present difficulties in management. In addition to treating the infection, it is necessary to establish bony stability, encourage fracture union and reconstruct the soft-tissue envelope.

We present a series of 67 infected nonunions of a long bone in 66 patients treated in a multidisciplinary unit. The operative treatment of patients suitable for limb salvage was performed as a single procedure. Antibiotic regimes were determined by the results of microbiological culture.

At a mean follow-up of 52 months (22 to 97), 59 patients (88%) had an infection-free united fracture in a functioning limb. Seven others required amputation (three as primary treatment, three after late failure of limb salvage and one for recalcitrant pain after union).

The initial operation achieved union in 54 (84%) of the salvaged limbs at a mean of nine months (three to 26), with recurrence of infection in 9%. Further surgery in those limbs that remained ununited increased the union rate to 62 (97%) of the 64 limbs treated by limb salvage at final follow-up. The use of internal fixation was associated with a higher risk of recurrent infection than external fixation.

Cite this article: Bone Joint J 2015; 97-B:814–17.

Background:. The aim of this study was to review the surgical complications and clinical outcomes of patients with Pilon fractures treated with Ilizarov frames. Methods:. Data collected included surgical complications, grade of initial injury using the Ruedi-Allgower classification and quality of reduction according to the Teeny and Wiss criteria. Outcome scores were collected retrospectively using the Foot and Ankle Disability Index (FADI). Results:. A total of 97 consecutive patients were identified. All patients were treated with indirect reduction by capsuloligamentotaxis and stabilisation using an ankle-spanning Ilizarov external fixator. The mean time to union was 6 months. Data was available for 70 patients. 35 patients developed a pin site infection. There were no cases of osteomyelitis. 4 patients developed a DVT and 1 patient a PE, 4 patients required ankle fusions. Quality of reduction according to the criteria of Teeny and Wiss was anatomic in 40 patients, good in 23 patients, fair in 6 patients, poor in 3 patients. Conclusion:. This is one of the larger series of Pilon factures on literature review. Ilizarov frame fixation achieves stable reduction of the fractured fragments without additional trauma to soft tissues with minimal complications and good functional results

Introduction:. Bicondylar tibial plateau fractures are serious periarticular injuries. We investigated outcomes in injuries managed with Ilizarov external fixators. Methods:. We retrospectively reviewed bicondylar tibial plateau fractures treated with Ilizarov fixators in a major trauma centre from 2008–2012. Radiological parameters were measured from standardised weight-bearing radiographs. A subset (n=34) had patient-related outcome measures. Results:. Of 80 injuries, all fractures united. Two developed septic arthritis and one osteomyelitis. 76.3% were graded a good-excellent outcome (Rasmussen radiological score). 30.3% had evidence of osteoarthritis (Kellgren Lawrence>1). Neither parameter correlated significantly with lower functional scores. Referrals from neighbouring hospitals had longer times to surgery, which associated with increased condylar widening (p=0.0214) and posterior tibial slope (p=0.0332). Risk of developing osteoarthritis correlated with lower joint line congruency angle (JLCA) (p=0.0017) and increased articular step-off (p=0.0008) on initial radiographs. 3 patients have progressed to total knee arthroplasty. Discussion and Conclusion:. This is the largest study of bicondylar tibial plateau fractures treated by Ilizarov fixation. Rates of septic arthritis and osteomyelitis compare with previously reported rates, with no cases of non-union. Over 76% achieved good-excellent radiological outcome, compared with 63–96% in studies of internal fixation. Achieving normal JLCA and smooth articular surface at the time of fixation reduce risk of developing osteoarthritis

Purpose of the study. The aim of this mechanical study was to investigate the ability of cannulated fixation bolts to stop wire slippage in Ilizarov circular external fixators. Methods and Results. Three types of cannulated fixation bolts (Smith and Nephew, Orthofix and one designed by the authors) were tested on Ilizarov rings to compare their performance. Three levels of bolt torques were applied and the wires were pulled to measure the load at which the wire will start to slip or fail. It was revealed that the initial resistance to slippage is due to plastic deformation of the wire under the clamp and is in fact governed by the size of this deformation. The slippage was found to occur in a slip/stick fashion, as the plastic deformation was propagated along the wire. Conclusion. The more the plastic deformation caused by the bolt on the wire the higher the initial resistance to loading

Conventional surgical treatment of relapsed or neglected club foot deformities is not always successful or easy to apply. The presence of shortened neurovascular structures and unhealthy skin may preclude the surgical interference. Bone resection in severe deformities results in short foot which is not satisfactory functionally and cosmetically. Objectives. In this study we evaluate the use of the bloodless technique for management of relapsed or neglected club foot deformities. Methods. From Jan 2000–2006, 64 cases older than 2 years with relapsed or neglected club foot deformities were referred to our center. Four cases were excluded because of inadequate follow up data. This thesis based on 60 consecutive cases (67 feet). The patients average age was 8 years and 4 months (range, 2–16 years). Seven cases were bilateral, 20 Left sides, and 34 Right sides. There were 57 relapsed club foot (5 bilateral), and 3 cases were neglected (2 bilateral). Patients with relapsed club foot had average 3 previous operations (range, 1–8 operations). There was no preoperative assembling of the apparatus. The construct was designed according to the condition of deformity: equinus, varus forefoot etc. Additional procedures, elongation of tendoachilis was done concomitantly with the original procedure in 10 cases. The patients were discharged from the hospital the same day of the operation. Results. The range of operative time was 1–3 hours with an average of 1.5 hours. Average time in the fixator was 19.6 weeks (range, 10 weeks–38 weeks). After fixator removal cast was applied for 2 months, followed by night splint and special shoes for their daily activities. The average follow-up period was 30.6 months (range, 12–84 months) after fixator removal. The results were good in 55 feet, fair in 9, bad in 3. Complications. All cases suffered from some sort of pin tract inflammation. For 8 cases: one of the wires had to be removed without anaesthesia due to persistent infection. For 3 cases: replacement of wires under general anaesthesia was performed. Oedema developed in the leg and dorsum of the foot or the ankle in 34cases. Frame adjustment under general anaesthesia in 3 cases. There are others such as: migration of the calcanean wire, 2 cases; over correction with valgus heel, two cases; flatfoot, 4 cases; talar subluxationin, 2 cases; talonavicular subluxation, one case; first metatarsophalangeal subluxation, 2 cases; flat topped talus, one case; broken wire, 2 cases and recurrence in 2 cases. Discussion. It seems logic that osteotomy of the tarsus must be carried out whenever skeletal growth of the foot is at such an advanced stage that correction can not be established by means of articular repositioning and remodeling. However, equinovarus deformity of the foot in 65 adults (38 feet) was treated by external fixator without open procedure (Oganesyan et al, 1996). After an average follow-up 10 years, satisfactory results were obtained in all feet except four. Conclusion. Ilizarov Treatment is lengthy, difficult, fraught with complications, and a technically demanding procedure. However, the complications did not affect the final outcome too much. Ilizarov method also offers the advantage of performing many additional procedures for other associated lower limb deformity. We believe that the bloodless technique using Ilizarov external fixator is an effective method in treating relapsed or neglected club foot deformities

Patient's non acceptance of a bulky external fixator, the incidence of fractures of the regenerate, muscle transfixion giving rise to contractures especially in the Tendo Achilles, increased index of consolidation and the frequency of infections has made Limb lengthening with external fixators alone unpopular. In a retrospective study, we evaluated the technique of limb lengthening over a sub muscular plate combined with Ilizarov external fixator as an alternative to external fixator alone and whether the combined procedure is successful in reducing the external fixator period. 15 patients (14 with length discrepancy in the lower limb and 1 with low stature) and a total of 16 limbs (15 tibiae and 1 femur) were lengthened over a sub muscular plate fixed on the proximal segment followed by corticotomy and application of external fixator. Lengthening was achieved at 1 mm/day followed by distal segment fixation with three or four screws on reaching the target length. The pre operative target length was successfully achieved in all patients at a mean of 4.4 cm (2.2 to 6.5 cm). The mean duration of external fixation was 59.2 days (33 to 107 days) with the mean external fixation index at 16.7 days/cm (10.95 to 23.78). Infection complicated the procedure in two patients and one patient had mild Tendo Achilles contracture. Lengthening over a plate drastically reduces the time external fixator needs to worn and is preferred by patients to limb lengthening over an external fixator alone. patient Lengthening over a plate provides an alternative method for limb lengthening, can be applied to children with open physes and to deformed bones. [Lengthening over a Plate]

Abstract. The specific methods of skeletal reconstruction of massive bone loss remains a topic of controversy. The problem increased in case of massive bone loss, extensive soft tissue scar, vascular compromise, and short tibial remnants. Aim of the work. We evaluate the use of fibula in association of Ilizarov external fixator in management of massive post traumatic bone loss of tibial shaft. Materials and methods. Between December 1999 and 2004, we treated 8 adult patients with bone loss 10 cm and more. The indication was massive bone loss, extensive soft tissue scar, vascular compromise, and short tibial remnants. Whole fibula was used in 6 conditions and partial fibula in 2. The average age was 30.5 years (range: 25:51). The fibulas were prepared for transfer either as a whole or partially transfer. Ilizarov device was applied with a special construct for each condition accordingly. Free latismus dorsi was applied in 1 patient, and fasciocutanious flaps in 2. Four patients with whole fibula transfer continued to wear orthosis for outdoor activities. Results. The mean follow-up period was 40 months (range: 24:96) after healing. All fractures heeled between 8 and 24 months. Conclusion. We concluded that the Ilizarov external fixator is effective in management of management of massive post traumatic bone loss of tibial shaft. It provides advantages of compensation of bone defects, length, and early rehabilitation. It has the disadvantages of long healing time, long orthotic support. Its advantages are clear in case of massive bone loss, extensive soft tissue scar, vascular compromise, and short tibial remnants

Purpose. Vitamin D is a key regulator of bone homeostasis. The enzyme CYP24A1 is responsible for transforming vitamin D into 24,25(OH)2vitD. The putative biological activity of 24,25(OH)2vitD remains unclear. Previous studies showed an increase in the circulating levels of this metabolite following a fracture in chicks. Our laboratory has engineered a mouse model deficient for the Cyp24a1 gene for studying the role of 24,25(OH)2vitD. We set out to study the role of 24,25(OH)2vitD in endochondral and intramembranous bone formation in fracture repair in this mouse model based on the results of the chick fracture repair study. Method. Wild-type and mutant Cyp24a1 gene deficient mice were subjected to two different surgical procedures to simulate bone development and fracture repair. To mimic endochondral ossification, we devised a modified technique to perform intramedullary nailing of a mouse tibia followed by an induced fracture. To evaluate intramembranous ossification, we applied distraction osteogenesis to a mouse tibia using a mini Ilizarov external fixator apparatus. Histomorphometric parameters and gene expression differences in fracture repair between the mutant mice and the wild-type controls were measured using micro computed tomography, histology and reverse-transcription quantitative PCR (RT-qPCR) respectively. Results. Quantitative histomorphometric results showed a delay in endochondral fracture repair in the mutant mice calluses as compared to the wild-type mice calluses. In the same model, gene expression of type X collagen in the callus was higher in the wild-type mice. These significant differences were fully rescued by injecting the mutant mice with exogenous 24,25(OH)2vitD. In the intramembranous bone formation model, we found a trend towards reduced bone formation in the gap created by the distraction process in the mutant mice as compared to the wild-type mice. However, the differences did not reach statistical significance. Conclusion. Our results support a role for 24,25(OH)2vitD in fracture repair which is more dominant in a chondrocyte-mediated bone formation pathway like endochondral ossification. Although our results did not reach statistical significance in the intramembranous ossification model, the observed trend suggests a potential role as well. Further study of the role of 24,25(OH)2vitD in bone healing has the potential to support novel approaches in accelerating bone formation and fracture repair

Introduction. The response of the intervertebral disc to asymmetric forces may accelerate degeneration through changes in the matrix. Macroscopically, the disc sustains structural changes that may play a part in the progression of a scoliotic curve. Molecularly, disc degeneration is the outcome of the action of matrix metalloproteases (MMPs), members of a family of enzymes that bring about the degradation of extracellular matrix components. In this study we measured in vivo the expression of MMPs in a rat scoliotic intervertebral disc and studied the effect of the degree of the deformity on their production. Methods. Asymmetric forces were applied in the intervertebral disc between the ninth and tenth vertebrae at the base of a rat tail with the use of a mini Ilizarov external fixator, under anaesthesia. Animals were categorised into three groups according to the degree of the deformity. In group I, the deformity that was applied on the intervertebral disc was 10°, in group II 30°, and in group III 50°. All the animals used were female Wistar rats before adulthood, to take into account the effect of growth for the study of intervertebral disc changes. The intact intervertebral discs outside the fixator were used as controls. After the rats' death on day 35, the tails were prepared and analysed with an immunohistochemical protocol for chromogenic detection and location of MMPs 1 and 12 in tissue sections of the intervertebral discs. Results. We recorded an increase of the concentration of the MMPs in all groups compared with controls. The quantity of the MMPs increased as the degree of the deformity progressed. MMPs were detected mainly in fibrocartilage cells of the degenerative part, which were formed as result of the compression forces. We detected a differentiation of a large number of disc cells into chondrocytes at the transitional zone of the intervertebral disc adjacent to the vertebral end plates. Conclusions. The application of asymmetric forces on the intervertebral discs of a rat tail results in an increase of MMP expression in the disc cells. The amount of MMPs produced is proportional to the degree of the deformity and has an asymmetrical pattern of distribution into the intervertebral disc

Background. Arthrogryposis Multiplex Congenita is a rare congenital disorder associated with multiple musculoskeletal contractures which causes substantial morbidity. Knee involvement is commonly seen among children with arthrogryposis, with flexion contracture being the most frequent. The purpose of this study was to assess the effectiveness of orthopaedic procedures, namely distal femoral supracondylar extension osteotomy and/or Ilizarov external fixator, on the ambulation status of children with knee flexion contracture and whether any functional gains are maintained at the latest follow-up. Methods. Fifteen patients were identified and their medical records reviewed. The mean age at their first surgery was 7.6 years (range, 2-16 years). The etiology for all patients was amyoplasia. The mean length of follow-up was 58 months (range, 12-117 months). Contractures were treated with femoral extension osteotomy (n=8), Ilizarov external fixator (n=2), or both (n=5). Results. Pre-operatively, 11 patients were non-ambulatory, three patients were household ambulators, and one patient walked with orthoses in the community. There was an average of 1.5 knee surgeries done per patient. At the latest follow-up, nine patients were ambulatory with technical aids, two patients were household ambulators, one patient used a wheelchair but was independent for transfers, and three patients remained non-ambulatory. The mean flexion contracture prior to the first surgery was 62.8 ± 26.7 degrees. Post-operatively, the mean flexion contracture was 13.5 ± 16.4 degrees. At the latest follow-up, the mean flexion contracture was 33.8 ± 23.6 degrees. There were complications in three patients which included infected hardware, transient neurological compromise, and pressure sores, which eventually all resolved. Conclusion. early and aggressive orthopaedic management of flexion contractures in children with arthrogryposis is supported by our findings, and may contribute to functional gains

Tibial fractures complicated by bone and/or soft tissue loss present a great challenge. Traditional methods of limb reconstruction are lengthy and may not yield satisfactory functional results. Despite its tremendous contribution to the management of this condition, the Ilizarov technique of bone transport has several problems and difficulties. The present study was carried out between 1997 and 2002 and included 21 patients with tibial fractures complicated by bone and soft tissue defects as a result of open fractures or surgical debridement of infected non-unions. The bone loss ranged from three to eleven cm. (average 4.7 cm.). Ages ranged from 12 to 54 years (average 28.8 years). The follow-up ranged from 24 to 75 months. The procedure included resection of all devitalised tissues, acute limb shortening to close the defect, application of the external fixator and metaphyseal osteotomy for re-lengthening. In all patients the fractures united with well aligned limbs. Acute limb shortening of up to six cm. was done in the lower third of the leg. Limb lengthening was done in all cases and ranged from 3 to 9.5 cm. (average 4 cm.). An Ilizarov external fixator was used in nine cases (41%) and a monolateral fixator in 13 cases (59%) with a total of 22 applications. Residual leg length discrepancy of more than 3cm. occurred in four cases (19%). Complications included one refracture, one transient peroneal nerve palsy and one equinus contracture of ten degrees. Satisfactory results were obtained in 93% of cases. Acute limb shortening and re-lengthening converts a complicated limb reconstruction into a relatively simpler one of linear limb lengthening, without the difficulties of traditional Ilizarov techniques and eliminated the need for soft tissue flaps. It is better instituted early in the management of these cases to ensure better functional results and shorter treatment time

Purpose: Arthrogryposis Multiplex Congenita is a rare congenital disorder associated with multiple musculo-skeletal contractures which causes substantial morbidity. Knee involvement is commonly seen among children with arthrogryposis, with flexion contracture of the knee being the most frequent knee deformity. Knee flexion contractures in the paediatric population are particularly debilitating as they affect ambulation. Treatment for knee flexion contractures requires numerous orthopaedic procedures and an extensive follow-up period. The purpose of this study was to assess the effectiveness of orthopaedic procedures, namely distal femoral extension osteotomy and/or Ilizarov external fixator, on the ambulation status of children with knee flexion contracture. Method: The medical records and radiological images of 16 paediatric patients with arthrogryposis and knee flexion contractures were reviewed. The etiology of all of them was amyoplasia except for one case of popliteal pterygium. The mean age of first surgery was 6.2 years (age range: 1–15 years). The mean length of follow-up was 83.9 months. All patients’ knee flexion contractures were treated with femoral extension osteotomy, Ilizarov external fixator, or both. Two patients previously had posterior soft tissue releases, including hamstrings lengthenings, proximal gastrocnemius release, and release of posterior capsule. Results: Prior to the initial surgery for knee flexion contracture, 13 patients were non-ambulatory. One patient was a household ambulator with flexed knees. Two patients walked with orthoses. There was an average of 1.8 surgeries done per patient, namely distal femoral extension osteotomy and/or Ilizarov external fixator. At the latest follow-up, 12 patients were ambulatory, including 11 children ambulating with technical aids (orthosis, walker, braces, or rollator walker) and one child ambulating without any technical aid. Four patients remained non-ambulatory. The mean total arc of motion was 64.8 degrees preoperatively, 63.1 degrees postoperatively, and 52.8 degrees at the latest follow-up. A mean loss of 6.8 degrees per year in total arc of motion occurred. There were complications in four patients which consist of infected hardware, transient neurological compromise, cast change, and pressure sore. Conclusion: Surgical correction of knee flexion deformities by distal femoral extension osteotomy and/or Ilizarov external fixator was effective in improving the ambulation status of children with arthrogryposis. At latest follow-up, the gradual loss of total arc of motion did not impact the ambulatory gains made by these procedures