Thumb carpometacarpal joint (CMCJ) arthritis is a common and debilitating condition. The mainstay of surgical management is Trapeziectomy. Concerns about possible functional implications of collapse of the metacarpal into the arthroplasty space as well as the potential for scaphometacarpal led to the development of techniques to try and prevent this. The purpose of this study was to investigate if there were any significant differences in the long-term outcomes of patients who participated in a randomized trial of trapeziectomy alone compared with trapeziectomy with ligament reconstruction and tendon interposition (LRTI).

Sixty-five patients participated in our original trial, the 1 year findings of which were published in 2007. These patients were invited for a follow-up visit at a mean of 17 years (range 15–20) postoperatively. Twenty-eight patients attended, who had 34 operations, 14 trapeziectomy alone and 20 with LRTI. Patients were asked to complete a visual analogue scale (VAS) for satisfaction with the outcome of their procedure, rated on a scale from 0 (most dissatisfied) to 100 (most satisfied). They also completed the short version of the Disabilities of the Arm, Shoulder and Hand Score (QuickDASH) at their appointment. They underwent a functional assessment with a hand therapist and had a radiograph of the thumb.

There were no statistically significant differences between the two groups in terms of satisfaction with surgery or functional outcomes, with most measurements showing minimal or no differences in means between the two groups. There was no difference in the space between the metacarpal and scaphoid on radiograph. Radial abduction was the only parameter that was significantly greater in the patients with simple trapeziectomy (median 79°) compared with trapeziectomy with LRTI (median 71°) (p = 0.04). Even at 17 years there is no significant benefit of LRTI over trapeziectomy alone for thumb carpometacarpal joint osteoarthritis.

Background:

Low Back Pain and Neck Pain rank 1 and 4 on the causes of years lost to disability (YLDs) in the UK. Treatment options are broad including popular approaches such as chiropractic care but with NHS funding limited to recent initiatives such as Any Qualified Provider (AQP).

Summary

In this study, OsteoAMP® bone graft showed superior fusion rates as compared to rhBMP-2 at all timepoints (p<0.004). Additionally, OsteoAMP® bone graft had >80% few adverse events as compared to rhBMP-2.

This study aimed to determine if the adoption of collagenase treatment is economically viable.

Xiapex collagenase was trialled at Gloucestershire Hospitals NHS Trust in 50 patients suitable for fasciectomy, with a palpable cord and up to two affected joints. Retrospective data for contracture angle pre-injection, immediately post-manipulation and at an average 6 weeks (range 2–17) clinic follow up was collected from medical notes. At follow up the post-procedure number of days required for return to activities of daily living (ADLs) and/or work were recorded, along with overall patient satisfaction rating.

Complete data was obtained for 43 patients of average age 67 (range 45–82). At follow up 88% had ≤ 20° residual contracture. Average days return to full ADLs was 9 and work was 11. Overall satisfaction was 8.6 out of 10. Xiapex patients required an average 1 hand physiotherapy appointment post-manipulation compared to 6 for fasciectomy, saving £172.20. Total cost for one treatment course, excluding physiotherapy, was £1166 for Xiapex compared to £2801 for palmar fasciectomy and £5352 for digital fasciectomy.

The level of contracture after one Xiapex treatment course permitted return of hand function in the majority of patients whose overall treatment course required less financial and hospital resources.

Finger arthroplasty lacks the success seen with hip and knee joint replacements. The Van Straten Leuwen Poeschmann Metal (LPM) prosthesis was intended for the proximal interphalangeal (PIP) joints. However revision rates of 30% after 19 months were reported alongside massive osteolysis. Three failed LPM titanium niobium (TiNb) coated cobalt chrome (CoCr) components were obtained- two distal and one proximal.

All three components were analysed using an environmental scanning electron microscope (ESEM). This gave the chemical composition of the surface to determine if the TiNb surface coating was still intact. The distal components were analysed using a ZYGO non-contact profilometer (1nm resolution) with the proximal component unable to be analysed due to its shape. ZYGO analysis gave the roughness average (Ra) of the surface and determined the presence of scratches, pitting and other damage.

Images obtained from both the ZYGO and the ESEM indicated that the surfaces of all components were heavily worn. On the articulating surfaces of both distal components unidirectional scratching was dominant, while the non-articulating surface showed multidirectional scratching. The presence of unidirectional scratching suggested two-body wear, whilst the multidirectional scratching on the non-articulating surface of the distal component suggested that trapped debris may have caused three-body wear.

The ESEM chemical analysis showed that in some regions on the distal component the TiNb coating had been removed completely and in other areas it had been scratched or penetrated. On the proximal component the TiNb coating had been almost completely removed from the articulating surfaces and was only present in small amounts on the non-articulating surfaces. There was little evidence of bone attachment to the titanium coating which was intended to help provide fixation.

ESEM images showed the coating had been removed in some sections where there was minimal scratching, suggesting this scratching did not impact significantly in the coating removal. Therefore here the main cause of coating removal may have been corrosion, although scratching may have also have played a part.

The osteolysis reported clinically may have been linked to the wear debris from the failed coating.

Outcome following wrist fractures is difficult to assess. There are many methods used to assess outcome following distal radius fractures, but may be that simply asking the patient for their level of satisfaction may be enough. We looked at 50 wrist fractures at 12 weeks post injury and compared their level of satisfaction with various respected outcome measures (Gartland and Verley, Sarmiento, Cooney, Patient-Rated Wrist Evaluation, Hand Function Score, and Disability of Arm Shoulder and Hand Score) to determine whether there was a correlation with their level of satisfaction. The aim was to determine which wrist scoring system best correlates with patient satisfaction and functional outcome and which individual variables predict a good outcome. Forty-five females and 5 males with a mean age of 66 years (range 19 to 93 years) were included in the study. Multivariate regression analysis was carried out using SPSS 17.

Patient satisfaction correlated best with the MacDermid, Watts and DASH scores. The variables in these scoring systems that best accounted for hand function were pain, ability to perform household chores or usual occupation, open packets and cut meat.

The McDermid, Watts and DASH scores provide a better measure of patient satisfaction than the Gartland and Verley, Sarmiento and Cooney scores, however they are all time consuming, complicated and may indeed not be necessary.

The four most important questions to ask in the clinic following wrist fractures are about severity of pain, ability to open packets, cut meat and perform household chores or usual occupation. This may provide a simple and more concise means of assessing outcome after distal radial fractures.

We often regard patient satisfaction as the best clinical indicator of outcome in the clinic situation. The aim of this study was to determine which wrist scoring system (Gartland and Verley, Sarmiento, Cooney, Patient-Rated Wrist Evaluation, Hand Function Score, and Disability of Arm Shoulder and Hand Score) best correlates with patient satisfaction and functional outcome and which individual variables predict a good outcome. Forty-five females and 5 males with a mean age of 66 years (range 19 to 93 years) were included in the study. Multivariate regression analysis was carried out using SPSS 13.

Patient satisfaction correlated best with the MacDermid, Watts and DASH scores. The variables in these scoring systems that best accounted for hand function were pain, ability to perform household chores, open packets, cut meat and perform the usual occupation.

The most important questions to ask in the clinic following wrist fractures are about pain, ability to perform household chores, open packets, cut meat and perform the usual occupation. The McDermid, Watts and DASH scores provide a better measure of patient satisfaction than the Gartland and Verley, Sarmiento and Cooney scores, however they are time consuming, complicated and may indeed not be necessary.

The aim of this study is to compare functional, clinical and radiological outcomes in K-wire fixation versus volar fixed-angle plate fixation in unstable, dorsally angulated distal radius fractures.

Fifty-four adult patients with an isolated closed, unilateral, unstable, distal radius fracture were recruited to participate in the study. Only dorsally displaced fractures with no articular comminution were included. Patients were randomised to have their fracture treated with either closed reduction and K-wire fixation (3 wires) or fixed-angle volar plating. Both groups were immobilised in a below elbow cast for six weeks. The wires removed in the outpatients at six weeks and both groups were referred for physiotherapy. Independent clinical review was performed at three and six months post injury. Functional scoring was performed using the DASH and Gartland and Werley scoring systems. Radiographs were evaluated by an independent orthopaedic surgeon.

Twenty-five patients were treated with a plate and twenty-nine with wires. There were no complications in the plate group. There were 9 complications in the K-wire group with 3 patients requiring a second operation (1 corrective osteotomy for malunion, 1 median nerve decompression and 1 retrieval of a migrated wire). The remaining complications included: 5 pin site infections (3 treated with early pin removal and 2 with oral antibiotics only), and 1 superficial radial nerve palsy. There were no tendon ruptures.

Both groups scored satisfactory functional results with no statistical difference. There was a statistically significant difference in the radiological outcomes with the plate group achieving better results.

We conclude that in unstable dorsally angulated distal radius fractures volar fixed-angle plate fixation is able to achieve comparable functional results to K-wire fixation with better radiological results and fewer complications. This has resulted in a change in our clinical practice.

Aim: Subtle intra-articular screw penetration of the distal radius during fracture fixation is difficult to determine using standard PA and lateral radiographs. The purpose of our study was to determine which radiographs most reliably identify penetration into the joint.

Methods: A distal volar locking plate was applied to an isolated cadaveric radius bone and a series of plain radiographs taken. The radius, fixed along its long axis, was allowed to rotate through 180 degrees and inclined, in increments, to 40 degrees. In the control group the distal screws did not breach the articular surface. In the study group the screws penetrated the articular surface by 1mm. In each group 65 plain radiographs were taken and the presence or absence of screw penetration scored by two blinded observers.

Results: Using Weighted Kappa analysis the overall inter-observer agreement for all views was 0.5 (CI 0.39 –0.63). However in 7 radiographs there was complete inter-observer agreement correctly identifying screw penetration of the articular surface. The articular surface was correctly identified as intact in 13 views. Only a 75 degrees pronated view, without inclination, was 100% sensitive and specific for identifying the absence or presence of screw penetration through the articular surface.

Conclusion: The intra-operative use of a 75 degrees pronated view may reduce the need for repeated use of the image intensifier and excessive irradiation during plate fixation of distal radius fractures.

Irradiating allograft bone may compromise the mechanical stability of the prosthesis-bone construct, potentially having adverse effects on the outcome of femoral impaction grafting at revision hip replacement. This in vitro study aimed to determine the effect of irradiation of allograft bone used in femoral impaction grafting on initial prosthesis stability.

Morsellised ovine femoral head bone was irradiated at 0 kGy (control), 15 kGy and 60 kGy. For each group, six ovine femurs were implanted with a cemented polished double taper stem following femoral impaction bone grafting. Dynamic hip joint loading was applied to the femoral head using a servo-hydraulic materials testing machine. The primary outcome was stem micromotion. Tri-axial micromotion of the stem relative to the bone at two sites was measured using linear variable differential transformers and non-contact laser motion transducers. Statistical analysis was performed using SPSS.

Compared to the control and 15 kGy groups, specimens in the 60 kGy group demonstrated statistically significant greater micromotion in the axial, antero-posterior and medio-lateral axes. A multi-factorial post-hoc power analysis based on the overall effect of group size indicated a power of 0.7. There was no difference in micromotion between the control and 15 kGy groups. The average micromotion in the axial axes was 63μm in the control and 59μm in the 15 kGy group.

The results of this study suggest that a maximum irradiation dose of 15 kGy may not affect initial prosthesis stability following femoral impaction grafting in this model and provide the basis for us to now proceed to in-vivo studies examining the effect of irradiated bone on implant stability over time.

Purpose: This study compares clinical and radiological outcomes of K-wire fixation with volar locking plate (i.e. fixed angle) fixation in unstable, dorsally angulated, distal radius fractures.

Materials and methodology: Fifty four adult patients with an isolated, closed, unstable, dorsally angulated fracture without articular comminution were randomised to closed reduction and K-wire fixation (3 wires) or volar locking plate fixation. All were immobilised in a cast for six weeks and prescribed physiotherapy. Independent clinical and radiological assessment was performed at 3 and 6 months post injury, using the DASH and Gartland & Werley scoring systems.

Results: Twenty-four patients were treated with a plate and thirty with K-wires.

There were no complications in the plate group. There were 9 complications in the K-wire group. Three patients required re-operation (for malunion, median nerve compression, and retrieval of a migrated wire). Remaining complications included: 5 pin-site infections and 1 superficial radial nerve palsy.

Plate fixation achieved statistically significant better radiological and functional results.

Conclusion: Volar locking plate fixation achieves better radiological and functional results with fewer complications than K-wire fixation in unstable, dorsally angulated, distal radius fractures.

Aim: Subtle intra-articular screw penetration of the distal radius during fracture fixation is difficult to determine using standard PA and lateral radiographs. The purpose of our study was to determine which radiographs most reliably identify penetration into the joint.

Methods: A distal volar locking plate was applied to an isolated radius bone and a series of plain radiographs taken. The radius, fixed along its long axis, was allowed to rotate through 180 degrees and inclined, in increments, to 40 degrees. In the control group the distal screws did not breach the articular surface. In the study group the screws penetrated the articular surface by 2mm. In each group 65 plain radiographs were taken and the presence or absence of screw penetration scored by two blinded observers.

Results: Using Weighted Kappa analysis the overall inter-observer agreement for all views was 0.5 (CI 0.39–0.63). However in 7 radiographs there was complete inter-observer agreement correctly identifying screw penetration of the articular surface. The articular surface was correctly identified as intact in 13 views. Only a 75 degrees pronated view, without inclination, was 100 % sensitive and specific for identifying the absence or presence of screw penetration through the articular surface.

Conclusion: The intra-operative use of a 75 degrees pronated view may reduce the need for repeated use of the image intensifier and excessive irradiation during plate fixation of distal radius fractures.

The aim of this study was to compare arthroscopy and MRI as methods of assessing cartilage quality in the wrist.

Patients and Methods: 15 patients were identified who had undergone both wrist MRI and arthroscopy as part of their investigations for degenerative causes of wrist pain. 5 patients had Keinbock‘s disease, 6 had scapholunate advanced collapse and 4 had scaphoid non union advanced collapse. A 3 point grading system for assessing cartilage quality was devised for both arthroscopy and MRI assessing 5 articular surfaces in the wrist joint.

Results: The scores for MRI and arthroscopy were compared statistically using Kappa analysis to assess compatibility. (where 0 equates to no agreement and 1 indicates complete agreement).

The overall Kappa score was 0.43 which shows ‘moderate’ correlation between the two methods. Individual Kappa scores for the articular surfaces were lunate fossa 0.21, proximal lunate 0.62, distal lunate 0.22, proximal capitate 0.42 and scaphoid fossa 0.56.

Conclusion: Although MRI is a useful investigation, at present it cannot replace arthroscopy in measuring cartilage quality. However it does remain an important investigation in the management of such patients. As the quality of MRI scanners improves it may be possible to avoid arthroscopy as a diagnostic procedure.

Magnetic Resonance Imaging (MRI) is gaining popularity for the evaluation of acute wrist injuries, but findings may be confusing with uncertain clinical significance. The presence of bone marrow oedema but no fracture following trauma has been described in the knee and referred to as a bone bruise. The clinical implications of similar findings in the scaphoid have not been described.

This study aims to describe the clinical and radiological findings of an acute wrist injury known as the scaphoid bone bruise. An MRI classification is proposed, and the outcome described.

Between April 2000 and October 2004 all patients who underwent MRI scanning following an acute injury for suspected scaphoid fracture were considered for this study. The scaphoid bone bruise was treated with a degree of caution and the injured limb placed in a below elbow cast for six weeks. Review was arranged at three months when, if symptomatic, a further MRI was performed. A descriptive grading system depending on the extent of the bone bruise was developed.

41 patients were included in the study. At three months 26 were asymptomatic. Seven defaulted from follow-up. Eight patients were still symptomatic and underwent further MRI scan. The bone bruise was classified into four grades according to the degree of oedema found on MRI. Seven patients were grade 1, 18 patients were grade 2, 11 grade 3, and the remaining five grade 4. Of the eight patients who underwent repeat MRI scanning all showed improvement of the bone bruise. At six months only 2 patients remained symptomatic.

While healing around the knee is seldom a problem, the possibility that scaphoid bone bruise may be a precursor to scaphoid non-union needs to be excluded. This study suggests that scaphoid bone bruise is a benign injury with predictable recovery over time and is unlikely to result in long-term morbidity in the form of non-union. It may be feasible to mobilise these injuries much sooner. However, further study with longer follow-up and repeat MRI scans is necessary to be confident that caution about these injuries is unnecessary.

Introduction: Osteoarthritis of the thumb is the second most common site of arthritis in humans. There are numerous operations for the condition, but perhaps the commonest is trapeziectomy, which can be supplemented with a suspension procedure generally using FCR.

It was the aim of this study to determine whether there is an advantage of one procedure over the other.

Materials and methods: 60 patients with either Eaton and Littler grade III or IV arthritis of the CMCJ of their thumbs were randomised into either having a traditional trapeziectomy (with no wiring), or a trapeziectomy with FCR suspension. The surgery was performed by the senior surgeon. All patients were assessed pre- and post operatively (at 3,6 and 12 months) by a physiotherapist measuring pain on visual analogue scores doing various activities, range of movement and grip and pinch strength. X-rays were taken at the same intervals.

Results: Patient satisfaction from both operations was similar. There was no significant difference between visual analogue scores. Measurement of the gap left by the trapeziectomy was less when trapeziectomy alone was performed.

Discussion: There is no obvious difference in the results of these two surgical techniques for treating OA of thumb CMCJ. It is not necessary to perform the FCR suspension.

Introduction: Accelerated rehabilitation programs following ACL reconstruction require adequate fixation strength. Staple fixation of grafts outside the tibial tunnel has been shown to have fixation strength comparable to interference screws. The use of bioresorbable polymer implants has potentially significant advantages especially if revision is required. The purpose of this study was to evaluate a new bioresorbable fixation staple using an ovine model.

Materials and Methods: Forty-eight mature sheep underwent unilateral cranial cruciate ligament (CrCl) reconstruction. The reconstruction comprised a loop of superficial digital flexor tendon (autograft) joined to a prosthetic ligament (LK-15). Femoral fixation was by endobutton. Tibial fixation of the LK-15 was with either a new Poly-L-lactic acid (PLLA) staple (Zimmer Japan/Gunze Ltd.) or a Cobalt-chrome (CoCr) staple. Biomechanical and histological responses were evaluated at 0, 6, 12 and 24 weeks.

Results: At all times post-reconstruction there were no significant differences between staple types for construct strength or stiffness (p> 0.05). The staple was not the site of reconstruction failure, and there were no adverse tissue reactions, for either staple type. Fibrous tissue was more often found at the interface of the CoCr staple.

Conclusions: The PLLA staple performed biomechanically as well as the metal staple for tibial fixation of cruciate ligament reconstructions. There were no significant observable adverse histological responses over the time intervals examined.

Introduction: The purpose of this study was to evaluate the micromotion of a femoral prosthesis relative to the femur in a revision hip replacement model.

Methods: A series of Ovine hip hemiarthroplasties were mechanically tested to detect micromotion of the femoral prosthesis relative to the femur 12 weeks following implantation. A mechanical testing device utilising muscle simulation of the major groups around the femur was designed. A 3D targeting system was developed using non-contact LASER transducers on the implant referenced to a second target on the overlying femur. Movement of this second target was measured with three LVDT’s (linear variable differential transformers).

Results: The system error was quantified in each femur to a resolution of the order of 15 microns. The mean micromotion, in 3D at two points assuming rigid body mechanics, was less than 50 microns for clinically stable implants. One stem was determined to be clinically loose and had a corresponding mean micromotion of 150 microns.

Conclusion: The method enabled measurement of 3Dmicromotion of a femoral prosthesis within the femur, during a laboratory approximation of normal physiological load cycles. The micromotion values corresponded to clinical outcomes, in a manner consistent with other reports in the literature. This system can be modified to allow targeting of different implants within a variety of bone types.

Introduction: New biological approaches to reconstruction of major bone deficiency such as the use of bone substitutes and growth factors are being developed. This paper reports on the adverse response to the Bioglass in comparison to allograft alone.

Aim: To compare the biological response to femoral impaction grafting and a cemented femoral stem when using allograft bone versus allograft bone plus a synthetic bone graft substitute, Bioactive glass.

Methods: Eighteen merino wethers underwent a left cemented hemi-arthroplasty and were randomised to have impaction allografting of the femur using either allograft alone (allograft group) or a 50:50 mix of allograft and Bioactive glass (Bioglass group). After sacrifice at 12 weeks, histological analysis of the femora at the levels of the proximal, mid and distal femoral stem and distal to the stem was undertaken.

Results: In the allograft group, there was a consistent response with bone graft incorporation being greatest in the proximal femur and occurring progressively less, more distally. Mineralised bone apposition in the graft occurred post-operatively after eight weeks. In contrast, in the Bioglass group, the response was inconsistent. Bone graft incorporation was either minimal, or there was partial or complete resorption of the bone graft with replacement by particulate-laden fibrous tissue and resorption of endocortical bone. Inflammation of the capsule tissue was noted in some cases.

Conclusion: In comparison to allograft alone, the use of Bioglass to supplement allograft for use in impaction grafting in ovine hip arthroplasty gave inferior results.