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Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_14 | Pages 27 - 27
1 Nov 2021
Gehrke T Althaus L Linke P Salber J Krenn V Citak M
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Arthrofibrosis is a relatively frequent complication after total knee arthroplasty. Although stiffness after total hip arthroplasty (THA), because of formation of heterotopic ossification or other causes, is not uncommon, to the authors’ best knowledge, arthrofibrosis after THA has not been described. The aim of this study is to describe the arthrofibrosis of the hip after primary total hip arthroplasty using an established clinical and histological classification of arthrofibrosis. We retrospectively examined all patients who were histologically confirmed to have arthrofibrosis after primary THA during revision surgery by examination of tissue samples in our clinic. Arthrofibrosis was diagnosed according to the histopathological SLIM-consensus classification, which defines seven different SLIM types of the periimplant synovial membrane. The SLIM type V determines the diagnosis of endoprosthesis-associated arthrofibrosis. The study population consists of 66 patients who were revised due to arthrofibrosis after primary THA. All patients had a limitation in range of motion prior to revision with a mean flexion of 90° (range from 40 to 125), mean internal rotation of 10° (range from 0 to 40) and mean external rotation of 20° (range from 0 to 50). All patients had histological SLIM type V arthrofibrosis, corresponding to endoprosthesis-associated arthrofibrosis. Histological examination revealed that seven patients (10.6%) had particle-induced and 59 patients (89.4%) had non-particle-induced arthrofibrosis. This is the first decription of endoprosthetic-associated arthrofibrosis after primary THA on the basis of a well-established histological classification. Our study results could enable new therapeutic and diagnostic opportunities in patients with such an arthrofibrosis. Surgeons should keep arthrofibrosis as a possible cause for stiffness and pain after primary total hip arthroplasty in mind. Level of evidence Diagnostic study, Level of Evidence IV. Thorsten Gehrke and Lara Althaus contributed equally to the writing of this manuscript


Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_3 | Pages 56 - 56
23 Feb 2023
Rahardja R Love H Clatworthy M Young S
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Arthrofibrosis is a less common complication following anterior cruciate ligament (ACL) reconstruction and there are concerns that undergoing early surgery may be associated with arthrofibrosis. The aim of this study was to identify the patient and surgical risk factors for arthrofibrosis following primary ACL reconstruction. Primary ACL reconstructions prospectively recorded in the New Zealand ACL Registry between April 2014 and December 2019 were analyzed. The Accident Compensation Corporation (ACC) database was used to identify patients who underwent a subsequent reoperation with review of operation notes to identify those who had a reoperation for “arthrofibrosis” or “stiffness”. Univariate Chi-Square test and multivariate Cox regression analysis was performed. Hazard ratios (HR) with 95% confidence intervals (CI) were computed to identify the risk factors for arthrofibrosis. 9617 primary ACL reconstructions were analyzed, of which 215 patients underwent a subsequent reoperation for arthrofibrosis (2.2%). A higher risk of arthrofibrosis was observed in female patients (adjusted HR = 1.67, 95% CI 1.22 – 2.27, p = 0.001), patients with a history of previous knee surgery (adjusted HR = 1.97, 95% CI 1.11 – 3.50, p = 0.021) and when a transtibial femoral tunnel drilling technique was used (adjusted HR = 1.55, 95% CI 1.06 – 2.28, p = 0.024). Patients who underwent early ACL reconstruction within 6 weeks of their injury did not have a higher risk of arthrofibrosis when compared to patients who underwent surgery more than 6 weeks after their injury (3.5% versus 2.1%, adjusted HR = 1.56, 95% CI 0.97 – 2.50, p = 0.07). Age, graft type and concomitant meniscal injury did not influence the rate of arthrofibrosis. Female sex, a history of previous knee surgery and a transtibial femoral tunnel drilling technique are risk factors for arthrofibrosis following primary ACL reconstruction


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_7 | Pages 73 - 73
1 Jul 2022
Aspinall S Godsiff S Wheeler P Hignett S Fong D
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Abstract. 20% of patients are severely dis-satisfied following total knee arthroplasty (TKA). Arthrofibrosis is a devastating complication preventing normal knee range of motion (ROM), severely impacting patient's daily living activities. A previous RCT demonstrated superiority of a high intensity stretching programme using a novel device the STAK tool compared with standard physiotherapy in TKA patients with arthrofibrosis. This study analyses the results when the previous “standard physiotherapy” group were subsequently treated with the STAK tool. Methods. 15 patients post TKA with severe arthrofibrosis and mean ROM 71° were recruited, (three cases had previously failed manipulation under anaesthetic (MUA). Patients received 8 weeks standard physiotherapy, then treatment with the STAK at home for 8 weeks. ROM, extension, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Oxford Knee Scores (OKS) were collected at various time-points. Results. Following standard physiotherapy there were small improvements in ROM (8°) (p<0.01), but no significant improvements in extension, OKS or WOMAC (p=0.39). Following the STAK treatment all outcomes significantly improved (p<0.01). STAK group; mean ROM (21° versus 8°, p < 0.001), extension 9° versus 2° (p < 0.01), WOMAC (18 points versus 3, p < 0.01), and OKS (8 points versus 4, p<0.01). No patients suffered any complications relating to the STAK. Conclusions. The STAK is effective in increasing ROM, extension and function, whilst reducing pain and stiffness. The device can be considered a cost-effective and valuable treatment following TKA. This is likely to increase the overall satisfaction rate and has potential to reduce the need for MUA


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 111 - 111
1 Mar 2006
Boldt J Munzinger U
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Aims: The purpose of this study was to determine whether internal mal-rotation of the femoral component is associated with arthrofibrosis in TKA. We hypothesized arthrofibrosis may be triggered by a combination of non-physiological kinematics (femoral component internal rotation) and a tight medial compartment. Methods: From a consecutive cohort of 3058 mobile bearing TKA forty-four (1.4%) cases were diagnosed as having arthrofibrosis, of which thirty-eight (86%) cases could be recruited. Thirty-eight patients with a well functioning TKA served as matched controls. Evaluation included CT investigation to determine femoral component rotation with reference to the transepicon-dylar axis (TEA). Results: Femoral components in the AF group were significantly (p< 0.00001) internally mal-rotated by a mean of 4.7 degrees ranging from ten degrees internal rotation (IR) to one degree external rotation (ER). Mean femoral rotational in the control group was parallel (0.3 degrees IR) to the TEA (six degrees IR to four degrees ER). Arthrofibrosis was not associated with age, gender, body-mass-index, or preoperative diagnosis. Conclusions: There is a highly significant association between arthrofibrosis in TKA and internal mal-rotation of the femoral component. On the base of these results it was hypothesized that non-physiological kinematics in TKA with mal-aligned femoral components influence and/or trigger arthrofibrosis in TKA. In TKA with arthrofibrosis, we now consider femoral CT evaluation with the view to surgically rebalancing the flexion gap and realigning the femoral component, when internal mal-rotation is confirmed


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 322 - 322
1 May 2010
Boldt JG
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The purpose of this study was to evaluate the femoral component rotation in a small subset of patients who had developed arthrofibrosis after mobile-bearing total knee arthroplasty (TKA). Arthrofibrosis was defined as flexion less than 90 degrees or a flexion contracture greater than 10 degrees following TKA. From a consecutive cohort of 3,058 mobile-bearing TKAs, 49 (1.6%) patients were diagnosed as having arthrofibrosis, of which 38 (86%) could be recruited for clinical assessment. Femoral rotation of a control group of 38 asymptomatic TKA patients matched for age, gender, and body mass index was also evaluated. The surgical epicondylar axis was compared with the posterior condylar axis for the femoral prosthesis. Femoral components in the arthrofibrosis group were significantly internally rotated by a mean of 4.7 degrees (SD 2.2 degrees, range 10 degrees internal to 1 degrees external). In the control group, the femoral component had a mean 0.3 degrees internal rotation (SD 2.3 degrees, range 4 degrees internal to 6 degrees external). Following mobile-bearing TKA, there is a significant correlation between internal femoral component rotation and chronic arthrofibrosis


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 158 - 158
1 Mar 2008
Boldt DJ Keblish P Munzinger U
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The purpose of this study was to determine whether internal mal-rotation of the femoral component is associated with arthrofibrosis in TKA. Multiple etiological factors have been suggested, but specific causes have not been identified. We hypothesized arthrofibrosis may be triggered by a combination of non-physiological kinematics (femoral component internal rotation) and a tight medial compartment. From a consecutive cohort of 3058 mobile bearing TKA forty-four (1.4%) cases were diagnosed as having arthrofibrosis, of which thirty-eight (86%) cases could be recruited. Thirty-eight patients with a well functioning TKA served as matched controls. Evaluation included CT investigation to determine femoral component rotation with reference to the transepicondylar axis (TEA). Results: Femoral components in the AF group were significantly (p< 0.00001) internally mal-rotated by a mean of 4.7 degrees ranging from ten degrees internal rotation (IR) to one degree external rotation (ER). Mean femoral rotational in the control group was parallel (0.3 degrees IR) to the TEA (six degrees IR to four degrees ER). Arthrofibrosis was not associated with age, gender, body-mass-index, or preoperative diagnosis. There is a highly significant association between arthrofibrosis in TKA and internal mal-rotation of the femoral component. On the base of these results it was hypothesized that non-physiological kinematics in TKA with mal-aligned femoral components influence and/or trigger arthrofibrosis in TKA


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 81 - 81
1 Jan 2003
Full Access

Background:. The purpose of this study was to determine whether internal mal-rotation of the femoral component is associated with arthrofibrosis in TKA. Multiple etiological factors have been suggested, but specific causes have not been identified. We hypothesized arthrofibrosis may be triggered by a combination of non-physiological kinematics (femoral component internal rotation) and a tight medial compartment. Methods:. From a consecutive cohort of 3058 mobile bearing TKA forty-four (1. 4%) cases were diagnosed as having arthrofibrosis, of which thirty-eight (86%) cases could be recruited. Thirty-eight patients with a well functioning TKA served as matched controls. Evaluation included CT investigation to determine femoral component rotation with reference to the transepicondylar axis (TEA). Results:. Femoral components in the AF group were significantly (p< 0. 00001) internally mal-rotated by a mean of 4. 7 degrees ranging from ten degrees internal rotation (IR) to one degree external rotation (ER). Mean femoral rotational in the control group was parallel (0. 3 degrees IR) to the TEA (six degrees IR to four degrees ER). Arthrofibrosis was not associated with age, gender, body-mass-index, or preoperative diagnosis. Conclusions:. There is a highly significant association between arthrofibrosis in TKA and internal mal-rotation of the femoral component. On the base of these results it was hypothesized that non-physiological kinematics in TKA with mal-aligned femoral components influence and/or trigger arthrofibrosis in TKA. Clinical Relevance:. In TKA with arthrofibrosis, we now consider femoral CT evaluation with the view to surgically rebalancing the flexion gap and realigning the femoral component, when internal mal-rotation is confirmed. *This study has been cleared by the Ethical Committee, University of Zurich, Switzerland


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 82 - 82
1 Jan 2003
Full Access

Background:. The purpose of this study was to determine whether internal mal-rotation of the femoral component is associated with arthrofibrosis in TKA. Multiple etiological factors have been suggested, but specific causes have not been identified. We hypothesized arthrofibrosis may be triggered by a combination of non-physiological kinematics (femoral component internal rotation) and a tight medial compartment. Methods:. From a consecutive cohort of 3058 mobile bearing TKA forty-four (1. 4%) cases were diagnosed as having arthrofibrosis, of which thirty-eight (86%) cases could be recruited. Thirty-eight patients with a well functioning TKA served as matched controls. Evaluation included CT investigation to determine femoral component rotation with reference to the transepicondylar axis (TEA). Results:. Femoral components in the AF group were significantly (p< 0. 00001) internally mal-rotated by a mean of 4. 7 degrees ranging from ten degrees internal rotation (IR) to one degree external rotation (ER). Mean femoral rotational in the control group was parallel (0. 3 degrees IR) to the TEA (six degrees IR to four degrees ER). Arthrofibrosis was not associated with age, gender, body-mass-index, or preoperative diagnosis. Conclusions:. There is a highly significant association between arthrofibrosis in TKA and internal mal-rotation of the femoral component. On the base of these results it was hypothesized that non-physiological kinematics in TKA with mal-aligned femoral components influence and/or trigger arthrofibrosis in TKA. Clinical Relevance:. In TKA with arthrofibrosis, we now consider femoral CT evaluation with the view to surgically rebalancing the flexion gap and realigning the femoral component, when internal mal-rotation is confirmed. *This study has been cleared by the Ethical Committee, University of Zurich, Switzerland


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_IV | Pages 396 - 396
1 Apr 2004
Boldt J Romero J Hodler J Zanetti M Drobny T Munzinger U
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The purpose of this study was to analyse a potential correlation of arthrofibrosis (AF) and femoral rotational mal-alignment in total knee arthroplasty (TKA). We hypothesized an increased internal mal-rotation of the femoral component leading to unphysiological kinematic motion of the arthroplastic knee joint. These repetitive microtrauma may then induce increased synovial hyperplasia leading to arthrofibrosis. Arthrofibrosis is an ill-defined entity that results in unsatisfactory outcome following TKA. Biological and mechanical factors have been suggested as etiology, but specific causes have not been identified. Methods: From a cohort of 3058 mobile bearing TKA 44 (1.4%) cases were diagnosed with arthrofibrosis, of which 38 (86%) cases underwent clinical examination and CT investigation to determine femoral component rotation taking the transepicondylar (TEA) axis as reference point. A control group with 38 well functioning TKA was compared. Results: Increased internal mal-rotation of the femoral component of 5.0° in the AF group (reference to the TEA) was highly significant (p < 0.001) ranging from 10°IR to 1°ER compared with the control group (0.0° parallel to TEA, 4°IR to 5°ER). Men younger than average for index TKA in this center with a decreased BMI, previous knee surgery (particularly correcting osteoto-mies), poliomyelitis, and OA had an increased risk of developing arthrofibrosis. PCL retaining or sacrificing, patella resurfacing or retaining had no increased prevalence for AF. Rheumatoid patients had a decreased risk of developing arthrofibrosis . Conclusion: The correlation of AF to femoral component internal mal-rotation was statistically significant (p < 0.001). These results confirm that unphysiological kinematics in TKA appear to be a major etiopathological factor for arthrofibrosis (AF). In this study femoral component internal mal-rotation has shown to be a significant risk factor in the development of arthrofibrosis. We, therefore, recommend consideration of early CT evaluation in cases with AF and, when internally mal-rotated, revision of the femoral component. This study has been cleared by the Ethical Committee, University of Zurich, Switzerland


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 255 - 255
1 May 2006
Hutchinson J Parish E Cross M
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Introduction: Stiffness following Total Knee Arthroplasty is a serious and debilitating complication. There are many different patient and surgical factors implicated in it cause. Previous studies have suggested that it will occur in approximately 1% of TKR patients. Arthrofibrosis is an uncommon but potentially debilitating cause in an otherwise well positioned implant. The cause of this abnormal scar formation is as yet unknown. The treatment of this condition remains difficult and controversial. Revision of the TKR has been suggested as the gold standard treatment as other operative strategies have had limited success. Our approach to this problem has been to conserve the prosthesis and try to release the scar tissue. Aim: The aim of this study is to assess the results of open arthrolysis in the treatment of established arthrofibrosis. Method: 1522 patients undergoing primary uncemented TKR have been prospectively followed up (2022 TKR’s) using the International Knee Society Scores. 13 patients underwent open Arthrolysis for stiffness post-op (Incidence 0.64%). The average age was 65 (range 50–78). 6 cases were simultaneous bilateral procedures (Incidence 1.2% of simultaneous bilateral procedures). The average time between TKR and arthrolysis was 14 months. Our average follow-op was 7.2 years (range 2 – 10 years). Results: The average ROM just prior to Arthrolysis was 58°. The average ROM six months after surgery had improved to 91° (p< 0.05). The average ROM at last follow-up was 95° (p< 0.05) with an average Knee Society score of 155 (pain 83, function 72). No patients have required revision of their components. Conclusions: We have found open arthrolysis a successful approach to post-op arthrofibrosis. Although a large procedure it has been well tolerated by our patients. They have had an improvement in range of movement by six months which has been maintained up to 10 years


Bone & Joint Research
Vol. 9, Issue 6 | Pages 302 - 310
1 Jun 2020
Tibbo ME Limberg AK Salib CG Turner TW McLaury AR Jay AG Bettencourt JW Carter JM Bolon B Berry DJ Morrey ME Sanchez-Sotelo J van Wijnen AJ Abdel MP

Aims. Arthrofibrosis is a relatively common complication after joint injuries and surgery, particularly in the knee. The present study used a previously described and validated rabbit model to assess the biomechanical, histopathological, and molecular effects of the mast cell stabilizer ketotifen on surgically induced knee joint contractures in female rabbits. Methods. A group of 12 skeletally mature rabbits were randomly divided into two groups. One group received subcutaneous (SQ) saline, and a second group received SQ ketotifen injections. Biomechanical data were collected at eight, ten, 16, and 24 weeks. At the time of necropsy, posterior capsule tissue was collected for histopathological and gene expression analyses (messenger RNA (mRNA) and protein). Results. At the 24-week timepoint, there was a statistically significant increase in passive extension among rabbits treated with ketotifen compared to those treated with saline (p = 0.03). However, no difference in capsular stiffness was detected. Histopathological data failed to demonstrate a decrease in the density of fibrous tissue or a decrease in α-smooth muscle actin (α-SMA) staining with ketotifen treatment. In contrast, tryptase and α-SMA protein expression in the ketotifen group were decreased when compared to saline controls (p = 0.007 and p = 0.01, respectively). Furthermore, there was a significant decrease in α-SMA (ACTA2) gene expression in the ketotifen group compared to the control group (p < 0.001). Conclusion. Collectively, these data suggest that ketotifen mitigates the severity of contracture formation in a rabbit model of arthrofibrosis. Cite this article: Bone Joint Res 2020;9(6):302–310


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_13 | Pages 108 - 108
1 Nov 2021
Manfreda F Gregori P Marzano F Caraffa A Donis A
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Introduction and Objective

Joint malleolar fractures have been estimated around 9% of all fractures. They are characterized by different both early and late complications. Among the latter, arthrofibrosis and early secondary arthrosis represent the two most common ones. Moreover, these two complications could be considered related to each other. Their real cause is still under investigation, even if residual post-operative hematoma and acute post-traumatic synovitis appear to be the most accredited. Supporting this hypothesis, joint debridement and the evacuation of the post-operative hematoma could represent a possible solution. The aim of this prospective study is to evaluate the role of arthroscopic lavage and debridement during internal fixation in order to prevent late joint complications.

Materials and Methods

Sixty consecutive patients who reported dislocated articular ankle fractures with surgical indication of open reduction and internal fixation (ORIF) have been included in this study. 27 patients underwent ORIF surgery associated with arthroscopic washout and debridement, while 33 patients, representing the control group, underwent just internal reduction and osteosynthesis. Patients with pure dislocations, non-articular fractures, polytrauma, previous local trauma, metabolic and connective pathologies were excluded. Follow-up was performed at 40 days (T1), 3 (T2) and 6 months (T3) after trauma for all patients. If necessary, some have been re-evaluated 12 months after the trauma. Efficacy of the treatment was evaluated through the VAS scale, Maryland scale, search for local complications such as dehiscence or infections, and finally radiographic evaluation. T-Student was estimated in order to individuate statistical significance.


Bone & Joint Research
Vol. 11, Issue 1 | Pages 32 - 39
27 Jan 2022
Trousdale WH Limberg AK Reina N Salib CG Thaler R Dudakovic A Berry DJ Morrey ME Sanchez-Sotelo J van Wijnen A Abdel MP

Aims

Outcomes of current operative treatments for arthrofibrosis after total knee arthroplasty (TKA) are not consistently positive or predictable. Pharmacological in vivo studies have focused mostly on prevention of arthrofibrosis. This study used a rabbit model to evaluate intra-articular (IA) effects of celecoxib in treating contracted knees alone, or in combination with capsular release.

Methods

A total of 24 rabbits underwent contracture-forming surgery with knee immobilization followed by remobilization surgery at eight weeks. At remobilization, one cohort underwent capsular release (n = 12), while the other cohort did not (n = 12). Both groups were divided into two subcohorts (n = 6 each) – one receiving IA injections of celecoxib, and the other receiving injections of vehicle solution (injections every day for two weeks after remobilization). Passive extension angle (PEA) was assessed in live rabbits at 10, 16, and 24 weeks, and disarticulated limbs were analyzed for capsular stiffness at 24 weeks.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 336 - 336
1 Mar 2004
Boldt J Hodler J Drobny T Munzinger U
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Aims: The purpose of this study was to determine whether internal malrotation of the femoral component is associated with arthroþbrosis in TKA. We hypothesized arthroþbrosis may be triggered by a combination of nonphysiological kinematics (femoral component internal rotation) and a tight medial compartment. Methods: From a consecutive cohort of 3058 mobile bearing TKA forty-four (1.4%) cases were diagnosed as having arthroþbrosis, of which thirty-eight (86%) cases could be recruited. Thirty-eight patients with a well functioning TKA served as matched controls. Evaluation included CT investigation to determine femoral component rotation with reference to the transepicondylar axis (TEA). Results: Femoral components in the AF group were signiþcantly (p< 0.00001) internally mal-rotated by a mean of 4.7 degrees ranging from ten degrees internal rotation (IR) to one degree external rotation (ER). Mean femoral rotational in the control group was parallel (0.3 degrees IR) to the TEA (six degrees IR to four degrees ER). Arthroþbrosis was not associated with age, gender, body-mass-index, or preoperative diagnosis. Conclusions: There is a highly signiþcant association between arthroþbrosis in TKA and internal mal-rotation of the femoral component. On the base of these results it was hypothesized that non-physiological kinematics in TKA with mal-aligned femoral components inßuence and/or trigger arthroþbrosis in TKA. In TKA with arthroþbrosis, we now consider femoral CT evaluation with the view to surgically rebalancing the ßexion gap and realigning the femoral component, when internal mal-rotation is conþrmed.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 131 - 131
1 Mar 2013
Baydoun HE Yang A Dalal AH Chmell SJ
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Background

With the projected 673% increase in total knee arthroplasties (TKA) through the year 2030 in the United States alone, arthrofibrosis will become one of the more commonly encountered challenges in orthopaedic surgery.

Methods

After obtaining Institutional Review Board approval we retrospectively reviewed the results of 19 patients with a mean age at the time of surgery of 55.4 years (41–83) who underwent arthroscopic lysis of adhesions (ALOA) for arthrofibrosis at a minimum of 3 months after primary total knee arthroplasty by a single surgeon (SJC) at a single institution. All patients underwent a standardized adhesiolysis in the operating room. All patients had a minimum of 6 months follow up. All patients underwent arthroscopic lysis of adhersions for restricted range of motion (ROM) after failing aggressive physical therapy. We defined restriction in ROM as any extension lag >5°, and flexion ≤90°. Eight patients underwent manipulation under anesthesia for ROM less than 90° after ALOA.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 459 - 459
1 Sep 2012
Aydogdu S Yagci T Sezak M Sur H
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We aimed to investigate the effect of Seprafilm®, a synthetic biomembran, on the intra-articular adhesion formation in an experimental arthrofibrosis model.

Twenty male white rabbits were randomly allocated into two groups of 10 animals in each. A standard surgical procedure aiming at the development of arthrofibrosis and including medial parapatellar arthrotomy, lateral eversion of the patella, partial synovectomy and debridement of anterior of supracondylar area and patella joint surface by scalpel was performed on all rabbits' right knees. Group 1 rabbits served as controls, and in Group 2 rabbits a Seprafilm®, barrier placed into the described area. In both groups, after surgery, knee joint was immobilized by a no.5 wire suture passing from the ankle and groin and keeping the joint in 140° of flexion. At 6th week, all animals were sacrificed and adhesion formation was evaluated both macroscopically and histo-pathologically. All data were semi-quantified and analyzed statistically by Fisher's exact test.

While all rabbits in control group displayed different rates of adhesion macroscopically (62.5% severe, 25% moderate, 12.5% mild), none in the study group had it. The average macroscopic adhesion score was 2.5 ± 0.75 in control group, and 0 in Seprafilm® group. Histopathologic evaluation also revealed microscopic adhesion in all rabbits in control group, but none in Seprafilm® group. Fibroblast proliferation in Seprafilm® group (100% mild) was significantly lower than in control group (62.5% severe, 37.5% moderate) (p<0.05).

In conclusion, use of Seprafilm® as a mechanical barrier may be of value against the formation of arthrofibrosis in risky knees such as septic and traumatic ones.


Bone & Joint Open
Vol. 1, Issue 8 | Pages 465 - 473
1 Aug 2020
Aspinall SK Wheeler PC Godsiff SP Hignett SM Fong DTP

Aims

This study aims to evaluate a new home medical stretching device called the Self Treatment Assisted Knee (STAK) tool to treat knee arthrofibrosis.

Methods

35 patients post-major knee surgery with arthrofibrosis and mean range of movement (ROM) of 68° were recruited. Both the STAK intervention and control group received standard physiotherapy for eight weeks, with the intervention group additionally using the STAK at home. The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Oxford Knee Scores (OKS) were collected at all timepoints. An acceptability and home exercise questionnaire capturing adherence was recorded after each of the interventions.


Bone & Joint Research
Vol. 7, Issue 3 | Pages 213 - 222
1 Mar 2018
Tang X Teng S Petri M Krettek C Liu C Jagodzinski M

Objectives

The aims of this study were to determine whether the administration of anti-inflammatory and antifibrotic agents affect the proliferation, viability, and expression of markers involved in the fibrotic development of the fibroblasts obtained from arthrofibrotic tissue in vitro, and to evaluate the effect of the agents on arthrofibrosis prevention in vivo.

Methods

Dexamethasone, diclofenac, and decorin, in different concentrations, were employed to treat fibroblasts from arthrofibrotic tissue (AFib). Cell proliferation was measured by DNA quantitation, and viability was analyzed by Live/Dead staining. The levels of procollagen type I N-terminal propeptide (PINP) and procollagen type III N-terminal propeptide (PIIINP) were evaluated with enzyme-linked immunosorbent assay (ELISA) kits. In addition, the expressions of fibrotic markers were detected by real-time polymerase chain reaction (PCR). Fibroblasts isolated from healthy tissue (Fib) served as control. Further, a rabbit model of joint contracture was used to evaluate the antifibrotic effect of the three different agents.


Bone & Joint Research
Vol. 6, Issue 3 | Pages 162 - 171
1 Mar 2017
Walker JA Ewald TJ Lewallen E Van Wijnen A Hanssen AD Morrey BF Morrey ME Abdel MP Sanchez-Sotelo J

Objectives

Sustained intra-articular delivery of pharmacological agents is an attractive modality but requires use of a safe carrier that would not induce cartilage damage or fibrosis. Collagen scaffolds are widely available and could be used intra-articularly, but no investigation has looked at the safety of collagen scaffolds within synovial joints. The aim of this study was to determine the safety of collagen scaffold implantation in a validated in vivo animal model of knee arthrofibrosis.

Materials and Methods

A total of 96 rabbits were randomly and equally assigned to four different groups: arthrotomy alone; arthrotomy and collagen scaffold placement; contracture surgery; and contracture surgery and collagen scaffold placement. Animals were killed in equal numbers at 72 hours, two weeks, eight weeks, and 24 weeks. Joint contracture was measured, and cartilage and synovial samples underwent histological analysis.


Bone & Joint Research
Vol. 3, Issue 3 | Pages 82 - 88
1 Mar 2014
Abdel MP Morrey ME Barlow JD Grill DE Kolbert CP An KN Steinmann SP Morrey BF Sanchez-Sotelo J

Objectives

The goal of this study was to determine whether intra-articular administration of the potentially anti-fibrotic agent decorin influences the expression of genes involved in the fibrotic cascade, and ultimately leads to less contracture, in an animal model.

Methods

A total of 18 rabbits underwent an operation on their right knees to form contractures. Six limbs in group 1 received four intra-articular injections of decorin; six limbs in group 2 received four intra-articular injections of bovine serum albumin (BSA) over eight days; six limbs in group 3 received no injections. The contracted limbs of rabbits in group 1 were biomechanically and genetically compared with the contracted limbs of rabbits in groups 2 and 3, with the use of a calibrated joint measuring device and custom microarray, respectively.