to determine the prevalence of asymptomatic pseudotumours after MoMHRA; and to measure Co and Cr ion levels as well as lymphocyte proliferation responses to Ni, Co and Cr (the principal elements in the CoCr alloy used in MoMHRA) in MoMHRA patients with and without asymptomatic pseudotumours.
Metal Ion Levels – The presence of pseudotumour was associated with significantly higher median serum cobalt levels (9.2mg/L vs. 1.9mg/L, p<
0.001), chromium levels (12.0mg/L vs. 2.1mg/L, p<
0.001), hip aspirate cobalt levels (1182 mg/L vs. 86.2mg/L, p=0.003), and aspirate chromium levels (883mg/L vs. 114.8mg/ L, p=0.006), as well as with inferior functional scores (OHS 41 vs. 47 p<
0.001). There was no significant difference in acetabular cup inclination angle (p=0.51). Lymphocyte Reactivity: A higher incidence and level of enhanced lymphocyte reactivity to Ni (p=0.001), but not to Co or Cr (the principal elements in the CoCr alloy used in metal-on-metal hip resurfacing implants), was found in patients with MoMHRA compared to the patients without MoM implants. However, lymphocyte reactivity to Co, Cr and Ni did not significantly differ in patients with pseudotumours compared to those patients without pseudotumours. Conclusion: The prevalence of asymptomatic pseudotumours in females was high, especially in females with bilateral MoMHRA implants (30%). The patients with ‘asymptomatic’ pseudotumours were in fact mildly symptomatic. Lymphocyte reactivity to Co, Cr and Ni did not differ in patients with pseudotumour compared to those patients without pseudotumours, suggesting that systemic hypersensitivity type IV reactions, mediated by lymphocyte reactivity to these metals, is not the dominant mechanism in pathogenesis of the soft tissue pseudotumours. Furthermore, pseudotumours were not detected in those patients who had normal levels of cobalt and chromium ions. This suggests that pseudotumours do not occur if MoM articulations are well functioning. Therefore, pseudotumours are likely to be a biological consequence of the large amount of metal debris generated in vivo due to excessive wear.
Recently, a series of locally destructive soft tissue pseudotumour has been reported in patients following metal-on-metal hip resurfacing arthroplasty (MoMHRA), requiring revision surgery in a high percentage of patients. Based on the histological evidence of lymphocytic infiltration, a delayed hypersensitivity reaction to nickel (Ni), chromium (Cr) or cobalt (Co) has been suggested to play a role in its aetiology. The aim of this study was to investigate the incidence and level of hypersensitivity reaction to metals in patients with pseudotumour.
Group 1: MoMHRA patients with pseudotumours, detected on the ultrasound and confirmed with MRI (n=6, 5 F:1 M, mean age 53 years); Group 2: MoMHRA patients without pseudotumours (n=13, 7 F:6 M, mean age 55 years); and Group 3: age-matched control subjects without metal implants (n=6, 4 F:2 M, mean age 54 years). Lymphocyte transformation tests (LTT) were used to measure lymphocyte proliferation responses to metals. Peripheral blood mononuclear cells were isolated from heparinized blood samples using standard Ficoll–Hypaque® (Pharmacia). The PBMC were cultured at a cell density of 106 cells/mL. Culture was set up in the presence of either:
medium alone; nickel chloride (Sigma; 10-4M-10-6M); cobalt chloride (10-4M-10-6M); and chromium chloride (10-4M-10-6M). After 5 days of culture, cells were pulsed with [3H]-thymidine and proliferation was assessed by scintillation counting. The stimulation index (SI) was calculated by the ratio of mean counts per minute of stimulated to unstimulated cultures. A SI value of greater than 2.0 was interpreted as a positive result.
Tribological studies of hip arthroplasty suggest that larger diameter metal-on-metal (MOM) articulations would produce less wear than smaller diameter articulations. Other advantages using these large femoral heads implants include better stability with lower dislocation rates and improved range of motion. The aim of the present study was to compare chromium (Cr), cobalt (Co) and titanium (Ti) ion concentrations up to 1-year after implantation of different large diameter MOM total hip arthroplasty (THA).
Statistical group comparison revealed significant difference for Cr (p=0.006), Co (p=0.047) and Ti (p=<
0.001). With Biomet implants presenting the best results for Cr and Co and Zimmer the highest Ti level.
Metal on Metal Hip Resurfacing Arthroplasty (MoMHRA) has gained popularity due to its perceived advantages of bone conservation and relative ease of revision to a conventional THR if it fails. Known MoMHRA-associated complications include femoral neck fracture, avascular necrosis/collapse of the femoral head/neck, aseptic loosening and soft tissue responses such as ALVAL and pseudotumours. This study’s aim was to assess the functional outcome of failed MoMHRA revised to THR and compare it with a matched cohort of primary THRs.
We report on a group of 20 metal-on-metal resurfaced hips (17 patients) presenting with a soft tissue mass associated with various symptoms. We describe these masses as pseudotumours. All patients underwent plain radiography and fuller investigation with CT, MRI and ultrasound. Where samples were available, histology was performed. All patients in this series were female. Presentation was variable; the most common symptom was pain or discomfort in the hip region. Other symptoms included spontaneous dislocation, nerve palsy, an enlarging mass or a rash. The common histological features were extensive necrosis and lymphocytic infiltration. Fourteen of the 20 cases (70%) have so far required revision to a conventional hip replacement and their symptoms have either settled completely or improved substantially since the revision surgery. Two of the three bilateral cases have asymptomatic pseudotumours on the opposite side. We estimate that about 1% of patients develop a pseudotumour in the first five postoperative years after a hip resurfacing. The cause of these pseudotumours is unknown and is probably multi-factorial, further work is required to define this; they may be manifestations of a metal sensitivity response. We are concerned that with time the incidence of these pseudotumours will increase.
Significant proximal femoral bone deficiency in revision hip surgery poses a considerable challenge, especially as revision hip surgery is increasing in prevalence. Many femoral prosthetic devices, which compensate for this bone loss, are available to surgeons but ideally one wants to restore viable proximal bone stock. The Oxford Universal Hip (OUH) has been designed and modified with these challenges in mind. This is atrimodular, non-locking device that allows for some rotation and subsidence in the cement. Load transfer occurs at the proximal wedge, thus avoiding proximal stress shielding. The OUH has been used extensively in both primary and revision hip surgery and is particularly useful when used in conjunction with proximal impaction bone grafting. The main aim of this study was to determine the clinical outcome of the patients. The viability and survivorship of the impacted bone graft was assessed in order to give some indication of adequate perfusion of the incorporated bone grafting. Between 1999 and 2002 the OUH, in combination with proximal impaction bone grafting, was implanted in 72 hip revisions in 69 patients. All patients were clinically evaluated using the Oxford Hip score. Histological samples of impacted bone grafting were analysed by a pathologist 2 years after implantation to assess viability and perfusion of the impacted bone graft. The Oxford Hip Score improved from a pre-operative to a post-operative score of 45 (26–58) to 24.3 (12–43) respectively (p<
0.001). The mean follow up time was 32.7 months and in that time there were no re-revisions for aseptic loosening. Histology demonstrated viable bone stock in the proximal femur where bone grafting had been impacted 2 years previously. The OUH is a versatile hip prosthesis for use in revision hip arthroplasty and is especially well suited to proximal impaction bone grafting where it is possible to restore viable bone stock
Bone stock loss secondary to debris and mechanic alin-stability presents a challenge in revision hip arthroplasty. The aim of our study is to evaluate the clinical outcome of revision hip arthroplasty using the Oxford hip prosthesis combined with impaction allografting. Between 1999 and 2002, we revised 72 hips in 69 patients using this technique (mean age 65years). Indications were aseptic loosening (56), infection (8), peri-prosthetic fracture (7) and a broken stem (1). The mean time to revision was 8.5 years (1–21years). Patients were assessed clinically and with the Oxford Hip Score (OHS) pre- and post-operatively. Fifty-seven patients also had acetabular revision. Four patients required femoral osteotomy to remove the old prosthesis. We used a mean of 1.8 (1–4) femoral heads per operation. Patients were mobilised partially weight bearing (8weeks) followed by a gradual return to full loading. Complications included peri-operative femoral fracture (6), infection (6), dislocation (10), DVT (1)and PE (2). The average blood transfusion was 1.8 units (0–9). The OHS improved from 45 (26–58) pre-operatively to 24.3 post-operatively (12–43). No hip has been re-revised for aseptic loosening at a mean follow-up of 32.7months (16–51). The Oxford hip is a trimodular prosthesis with a polished tapered metaphyseal section that is free to slide and rotate on the stem. The stem is first inserted uncemented into the diaphysis. Bone graft is impacted proximally, with mesh if necessary, and then the proximal wedge is cemented in. The wedge allows for some subsidence in the cement and creates optimal radial force transmission, which is essential for bone-remodelling stimulation and preventing proximal stress shielding. Although this is a short-term experience, we believe that the use of the tri-modular Oxford stem combined with minimal proximal impaction allografting is a reliable method of dealing with difficult revision femoral surgery. The results were comparable with a primary arthroplasty in terms of pain relief and functional results.
Oxford Unicompartmental knee arthroplasty (UKA) is now performed using a minimally invasive surgical (MIS) technique. Although early results are encouraging, the studies assessing outcome could be criticised for the restricted number of patients and limited follow-up. Aim of this study was to assess clinical outcome and prosthetic survival rate inpatients with minimally invasive Oxford medial UKA. This prospective study assessed 500 consecutive patients, who underwent cemented Oxford UKA for medial OA using MIS technique. Patients were assessed using objective and functional Knee Society Score (KSS). This study has confirmed preliminary findings that Oxford UKA using a minimally invasive approach is safe, reliable and effective.
The Charnley Elite femoral component was first introduced in 1992 as a new design variant of the original Charnley femoral component (De Puy, Leeds, UK) with modified neck and stem geometry. The original component had undergone few changes in nearly forty years and has excellent long-term results. Early migration of the new stem design was determined by Roentgen Stereophotogrammetric Analysis (RSA)1. Rapid early migration of a component relative to the bone, measured by RSA, is predictive of subsequent aseptic loosening for a number of femoral stems. As there was rapid early migration and rotation of the Charnley Elite stem, we predicted that the long-term results would be poor. An outcome assessment is indicated as stems of this type are still being implanted. One hundred Charnley Elite stems, implanted in our centre between 1994 and 1997 were included in a prospective, cross-sectional follow-up study. Outcome measures include validated clinical scores (Charnley hip score, Harris hip score and Oxford hip score) and radiological scores (Gruen classification) as well as revision rates over the past 10 years. The clinical follow-up supports the RSA predictions of early failure of the Charnley Elite femoral stem.