The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma

N. Asano; T. Yamakazi; M. Seto; A. Matsumine; H. Yoshikawa; A. Uchida

doi:10.1302/0301-620X.86B4.14484

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The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma

N. Asano
T. Yamakazi
M. Seto
A. Matsumine
H. Yoshikawa
A. Uchida

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The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma

Asano N, Yamakazi T, Seto M, Matsumine A, Yoshikawa H, Uchida A. The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma. J Bone Joint Surg Br. 2004;86-B(4):607-612. doi:10.1302/0301-620X.86B4.14484

Asano, N., et al. “The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma.” The Journal of Bone & Joint Surgery British Volume, vol. 86-B, no. 4, 2004, pp. 607-612., https://doi.org/10.1302/0301-620X.86B4.14484

Asano, N., Yamakazi, T., Seto, M., Matsumine, A., Yoshikawa, H., & Uchida, A. (2004). The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma. The Journal of Bone & Joint Surgery British Volume, 86-B(4), 607-612. https://doi.org/10.1302/0301-620X.86B4.14484

Asano, N., Yamakazi, T., Seto, M., Matsumine, A., Yoshikawa, H. and Uchida, A. (2004) “The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma.” The Journal of Bone & Joint Surgery British Volume, 86-B(4), pp. 607-612. Available at: https://doi.org/10.1302/0301-620X.86B4.14484

Asano, N., T. Yamakazi, M. Seto, A. Matsumine, H. Yoshikawa, and A. Uchida. “The expression and prognostic significance of bone morphogenetic protein-2 in patients with malignant fibrous histiocytoma.” The Journal of Bone & Joint Surgery British Volume 86-B, no. 4 (2004): 607-612. https://doi.org/10.1302/0301-620X.86B4.14484

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Abstract

We investigated the rates of expression of bone morphogenetic protein-2 (BMP-2) in 29 adult patients with high-grade malignant fibrous histiocytoma of soft tissue, using the BMP-2-specific monoclonal antibody, AbH3b2/17, and found that they ranged from 1.9% to 78.9%. The survival at five years of the groups expressing high (≥30%) and low (< 30%) levels of BMP-2 was 85.7% and 36.3%, respectively. Multivariable analysis showed that only BMP-2 had prognostic significance for continuous disease-free survival and for overall survival (p < 0.05). Our findings indicate that over-expression of BMP-2 in malignant fibrous histiocytoma of soft tissue is the most reliable prognostic indicator of the parameters assessed.

Correspondence should be sent to Dr N. Asano.

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