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Top ten research priorities for problematic knee arthroplasty

a Priority Setting Partnership led by the British Association for Surgery of the Knee and the James Lind Alliance

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The James Lind Alliance aims to bring patients, carers, and clinicians together to identify uncertainties regarding care. A Priority Setting Partnership was established by the British Association for Surgery of the Knee in conjunction with the James Lind Alliance to identify research priorities related to the assessment, management, and rehabilitation of patients with persistent symptoms after knee arthroplasty.


The project was conducted using the James Lind Alliance protocol. A steering group was convened including patients, surgeons, anaesthetists, nurses, physiotherapists, and researchers. Partner organizations were recruited. A survey was conducted on a national scale through which patients, carers, and healthcare professionals submitted key unanswered questions relating to problematic knee arthroplasties. These were analyzed, aggregated, and synthesized into summary questions and the relevant evidence was checked. After confirming that these were not answered in the current literature, 32 questions were taken forward to an interim prioritization survey. Data from this survey informed a shortlist taken to a final consensus meeting.


A total of 769 questions were received during the initial survey with national reach across the UK. These were refined into 32 unique questions by an independent information specialist. The interim prioritization survey was completed by 201 respondents and 25 questions were taken to a final consensus group meeting between patients, carers, and healthcare professionals. Consensus was reached for ranking the top ten questions for publication and dissemination.


The top ten research priorities focused on pain, infection, stiffness, health service configuration, surgical and non-surgical management strategies, and outcome measures. This list will guide funders and help focus research efforts within the knee arthroplasty community.

Cite this article: Bone Joint J 2020;102-B(9):1176–1182.

Correspondence should be sent to John A. Mathews. E-mail:

Simon Abram, Abtin Alvand, Neil Artz, John Brooks, Rachel Bray, Tricia Ellis, David Hillebrandt, Nicholas Howells, Beverley Hopwood, John Mathews, James Murray, Jon Phillips, Andrew Porteous, Andrew Price, Bill Rowles, David Searle, Rowenna Stroud, Ian Tanner, Polly Tarrant, Andrew Toms, Ben Waterson, Vikki Wylde

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