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The Bone & Joint Journal
Vol. 102-B, Issue 12 | Pages 1760 - 1766
1 Dec 2020
Langlais T Hardy MB Lavoue V Barret H Wilson A Boileau P

Aims

We aimed to address the question on whether there is a place for shoulder stabilization surgery in patients who had voluntary posterior instability starting in childhood and adolescence, and later becoming involuntary and uncontrollable.

Methods

Consecutive patients who had an operation for recurrent posterior instability before the age of 18 years were studied retrospectively. All patients had failed conservative treatment for at least six months prior to surgery; and no patients had psychiatric disorders. Two groups were identified and compared: voluntary posterior instability starting in childhood which became uncontrollable and involuntary (group VBI); and involuntary posterior instability (group I). Patients were reviewed and assessed at least two years after surgery by two examiners.


The Bone & Joint Journal
Vol. 100-B, Issue 9 | Pages 1234 - 1240
1 Sep 2018
Brady J Hardy BM Yoshino O Buxton A Quail A Balogh ZJ

Aims

Little is known about the effect of haemorrhagic shock and resuscitation on fracture healing. This study used a rabbit model with a femoral osteotomy and fixation to examine this relationship.

Materials and Methods

A total of 18 male New Zealand white rabbits underwent femoral osteotomy with intramedullary fixation with ‘shock’ (n = 9) and control (n = 9) groups. Shock was induced in the study group by removal of 35% of the total blood volume 45 minutes before resuscitation with blood and crystalloid. Fracture healing was monitored for eight weeks using serum markers of healing and radiographs.


The Bone & Joint Journal
Vol. 96-B, Issue 9 | Pages 1178 - 1184
1 Sep 2014
Tarrant SM Hardy BM Byth PL Brown TL Attia J Balogh ZJ

There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine the rate of preventable mortality and errors during the management of these patients. A 12 month prospective study was performed on patients aged > 65 years who had sustained a fracture of the hip. This was conducted at a Level 1 Trauma Centre with no orthogeriatric service. A multidisciplinary review of the medical records by four specialists was performed to analyse errors of management and elements of preventable mortality. During 2011, there were 437 patients aged > 65 years admitted with a fracture of the hip (85 years (66 to 99)) and 20 died while in hospital (86.3 years (67 to 96)). A total of 152 errors were identified in the 80 individual reviews of the 20 deaths. A total of 99 errors (65%) were thought to have at least a moderate effect on death; 45 reviews considering death (57%) were thought to have potentially been preventable. Agreement between the panel of reviewers on the preventability of death was fair. A larger-scale assessment of preventable mortality in elderly patients who sustain a fracture of the hip is required. Multidisciplinary review panels could be considered as part of the quality assurance process in the management of these patients.

Cite this article: Bone Joint J 2014;96-B:1178–84.


Bone & Joint Research
Vol. 2, Issue 9 | Pages 186 - 192
1 Sep 2013
Boivin GP Platt KM Corbett J Reeves J Hardy AL Elenes EY Charnigo RJ Hunter SA Pearson KJ

Objectives

The goals of this study were: 1) to determine if high-fat diet (HFD) feeding in female mice would negatively impact biomechanical and histologic consequences on the Achilles tendon and quadriceps muscle; and 2) to investigate whether exercise and branched-chain amino acid (BCAA) supplementation would affect these parameters or attenuate any negative consequences resulting from HFD consumption.

Methods

We examined the effects of 16 weeks of 60% HFD feeding, voluntary exercise (free choice wheel running) and BCAA administration in female C57BL/6 mice. The Achilles tendons and quadriceps muscles were removed at the end of the experiment and assessed histologically and biomechanically.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 10 | Pages 1361 - 1363
1 Oct 2005
Hardy JRW Chimutengwende-Gordon M Bakar I

We reviewed the records of 107 consecutive patients who had undergone surgery for disruption of the knee extensor mechanism to test whether an association existed between rupture of the quadriceps tendon and the presence of a patellar spur. The available standard pre-operative lateral radiographs were examined to see if a patellar spur was an indicator for rupture of the quadriceps tendon in this group of patients. Of the 107 patients, 12 underwent repair of a ruptured patellar tendon, 59 had an open reduction and internal fixation of a patellar fracture and 36 repair of a ruptured quadriceps tendon. In the 88 available lateral radiographs, patellar spurs were present significantly more commonly (p < 0.0005) in patients operated on for rupture of the quadriceps tendon (79%) than in patients with rupture of the patellar tendon (27%) or fracture of the patella (15%). In patients presenting with failure of the extensor mechanism of the knee in the presence of a patellar spur, rupture of the quadriceps tendon should be considered as a possible diagnosis.


The Journal of Bone & Joint Surgery British Volume
Vol. 80-B, Issue 3 | Pages 485 - 489
1 May 1998
Clatworthy MG Clark DI Gray DH Hardy AE

We performed a randomised, prospective trial to evaluate the use of unreamed titanium nails for femoral fractures. Of 48 patients with 50 femoral fractures 45 were followed to union; 23 with an unreamed and 22 with a reamed nail. The study was stopped early because of a high rate of implant failure.

The fractures in the unreamed group were slower to unite (39.4 weeks) than those in the reamed group (28.5 weeks; p = 0.007). The time to union was over nine months in 57% of the unreamed group and in 18% of the reamed group.

In the unreamed group 14 secondary procedures were required in ten patients to enhance healing compared with three in three patients in the reamed group. Six implants (13%) failed, three in each group. Four of these six fractures showed evidence of delayed union.

To achieve quicker union and fewer implant failures we recommend the use of reamed nails of at least 12 mm in diameter for female patients and 13 mm in males.


The Journal of Bone & Joint Surgery British Volume
Vol. 78-B, Issue 3 | Pages 510 - 510
1 May 1996
HARDY JRW GREGG PJ WOOD


The Journal of Bone & Joint Surgery British Volume
Vol. 77-B, Issue 3 | Pages 412 - 416
1 May 1995
Richardson J Gardner T Hardy Evans M Kuiper J Kenwright J

We studied the effect of 'dynamisation' on tibial fractures in six patients treated by the Dynamic Axial Fixator. In the early stages, peak cyclic movement at two to four weeks averaged 0.75 mm (0.19 to 1.02) on the medial side of the bone and 0.86 mm (0.21 to 1.25) on the lateral side. The amount of movement correlated with the applied load and the fracture stiffness. After unlocking the fixator column at six weeks, progressive closure of the gap averaged 1.3 mm (0.1 to 3.5). Cyclic movement is produced by early weight-bearing with the fixator column locked. Progressive closure occurs after unlocking the column, and is often associated with a reduction in cyclic movements. The effects of dynamisation on movement at the fracture site should be defined separately, in terms of cyclic movement and of progressive closure.


The Journal of Bone & Joint Surgery British Volume
Vol. 75-B, Issue 4 | Pages 645 - 649
1 Jul 1993
Hardy Conlan D Hay S Gregg P

The changes in serum adjusted ionised calcium and parathyroid hormone (PTH) were prospectively studied in 32 patients with isolated tibial fractures, treated conservatively. We measured serum albumin, adjusted total calcium, phosphate, pH, adjusted ionised calcium and PTH at intervals until the fractures had healed. The mean ionised calcium adjusted for pH fell within 24 hours of injury, and then rose to a peak at between four and six weeks. These changes cannot be explained by changes in serum pH or PTH. The restoration of normal ionised calcium levels after fracture coincided with the period when the callus was being calcified. Analysis of the changes in ionised calcium, phosphate and PTH suggests that PTH levels alter in response to changes in ionised calcium levels. PTH is highest immediately after fracture and lowest, often not recordable, at six weeks. The cause of the changes in the ionised calcium level has yet to be elucidated.


The Journal of Bone & Joint Surgery British Volume
Vol. 74-B, Issue 2 | Pages 320 - 320
1 Mar 1992
Hardy


The Journal of Bone & Joint Surgery British Volume
Vol. 74-B, Issue 1 | Pages 154 - 154
1 Jan 1992
Hardy


The Journal of Bone & Joint Surgery British Volume
Vol. 73-B, Issue 5 | Pages 732 - 740
1 Sep 1991
Hardy D Frayssinet P Guilhem A Lafontaine M Delince P

We examined specimens of hydroxyapatite-coated femoral prostheses from four patients who had died within nine months of implantation for fractured neck of femur. Histology showed newly formed immature bone overlying the hydroxyapatite coating with new trabeculae bridging to the endosteal bone layer. In the diaphysis, where there had been contact between the hydroxyapatite and the cortex, there was dense, firmly anchored bone with an haversian architecture. In other places the newly formed bone had a trabecular structure, containing bone marrow tissue with normal cellularity. It appeared that biological osseointegration had taken place.


The Journal of Bone & Joint Surgery British Volume
Vol. 70-B, Issue 4 | Pages 673 - 673
1 Aug 1988
Hardy A Synek V


The Journal of Bone & Joint Surgery British Volume
Vol. 69-B, Issue 5 | Pages 838 - 839
1 Nov 1987
Hardy A

A method of assessing foot movement suitable for use in clinical practice is presented. The method assesses the component of movement in the horizontal plane which is produced by rotating the calcaneum about the axis of the subtalar joint.


The Journal of Bone & Joint Surgery British Volume
Vol. 68-B, Issue 4 | Pages 643 - 646
1 Aug 1986
Szypryt E Hardy J Colton C

Radiopharmaceuticals have been successfully used to detect occult neoplasms and infective lesions. Bone scans using 99mTc-labelled methylene diphosphonate located osteoid osteomas accurately in a series of 30 symptomatic patients. A portable radiation detector system has been designed to help intra-operative localisation and facilitate complete excision of the lesions with minimal damage to normal tissue. A sodium iodide detector with a fibre-optic link was used at first, but a cadmium telluride system has provided a more durable, reliable and sensitive sterilisable probe.


The Journal of Bone & Joint Surgery British Volume
Vol. 68-B, Issue 1 | Pages 121 - 124
1 Jan 1986
Barnes M Hardy A

Thirteen patients with ruptures of the calcaneal tendon diagnosed more than four weeks after injury were reviewed. Eleven patients had operative reconstruction with tendon shortening and the postoperative follow-up ranged from one to seven years. Isometric and isokinetic measurements, as well as the strength of the triceps surae, all compared favourably with the normal contralateral leg. Only one tendon re-ruptured. Eight of the eleven patients were satisfied with the results and the two patients who had refused reconstruction had worse functional results. Late reconstruction of a ruptured calcaneal tendon is thus a worthwhile procedure.


The Journal of Bone & Joint Surgery British Volume
Vol. 63-B, Issue 4 | Pages 597 - 600
1 Nov 1981
Minford A Hardy G Forsythe W Fitton J Rowe V

A 13-year-old girl presented with a two-year history of pain in the right thigh and right forearm. Engelmann's disease was diagnosed on the basis of radiological appearances and histological examination of the bone. Her symptoms subsided after biopsy of the bone, but two weeks later she developed severe pain in the left tibia and was unable to walk. Radiological features of Engelmann's disease were found in the left tibia and other long bones although these bones had been radiologically normal one month previously. Treatment with prednisolone gave rapid relief of pain and allowed the patient to become mobile again. Four months later the radiological appearances showed significant improvement. The use of corticosteroids in this disorder is discussed.


The Journal of Bone & Joint Surgery British Volume
Vol. 63-B, Issue 1 | Pages 98 - 101
1 Feb 1981
Hardy A

Between March 1969 and May 1978, 36 babies sustained birth injuries of the brachial plexus at the National Women's Hospital, Auckland, New Zealand. This gives an incidence of 0.87 per 1000 live births. Nearly 80 per cent of these children had made a complete recovery by the age of 13 months, while none of those with significant residual defects has severe sensory or motor deficit of the hand.


The Journal of Bone & Joint Surgery British Volume
Vol. 61-B, Issue 2 | Pages 151 - 154
1 May 1979
Hardy A White P Williams J

Seventy-nine cases of fracture of the femoral shaft treated by cast-brace and early walking have been reviewed. Discrepancy in femoral length was assessed by scanogram. The cases were analysed to relate the incidence of shortening greater than 2 centimetres to the type and site of the fracture, and the time which elapsed from injury until the cast-brace was applied. Such shortening was encountered most frequently when the cast-brace was applied within the first two weeks from injury or after six weeks and in those patients with comminuted fractures of the middle third of the femoral shaft.


The Journal of Bone & Joint Surgery British Volume
Vol. 55-B, Issue 4 | Pages 889 - 890
1 Nov 1973
Hardy A


The Journal of Bone & Joint Surgery British Volume
Vol. 45-B, Issue 1 | Pages 76 - 87
1 Feb 1963
Hardy AG Dickson JW

1. Ectopic ossification is commonest in, but not confined to, traumatic paraplegia. It occurs also in many other neurological disorders which have in common a gross disturbance of spinal cord reflex activity. It is a true ossification and must be distinguished from calcification.

2. The neurological lesion may lie anywhere from the cerebral cortex to the mixed peripheral nerve. It may involve motor tracts, sensory tracts or a mixture of both.

3. The ossification is localised and self-limiting. It occurs mainly in the lower limbs and is restricted to certain muscles or muscle groups, the nerve supply of which is always below the level of the central neurological lesion.

4. The blood chemistry is usually normal.

5. A true arthropathy is rare except as part of a secondary suppurative arthritis.

6. The resemblance to myositis ossificans progressiva or to ossifying haematoma is only superficial, although the pathological process at cellular level may be the same.

7. The period of onset after paraplegia is variable. The earliest recorded example is in one of our own cases in which ossification occurred nineteen days after injury. Other patients have developed ossification after several years.

8. The condition is commonest in acquired nervous disease rather than in congenital disorders, and so far as we know it has not been described in the myopathies. The presence of muscular spasticity or flaccidity is relevant only in that it indicates a disturbance of reflex activity.

9. Soft-tissue ulceration appears to be frequently associated with ectopic ossification. The type of new bone formation associated with large chronic ulcers is not to be compared with the new bone formation in the muscles of a paraplegic patient in otherwise good general condition.

10. The occurrence of urinary tract infections with calculi and generalised sepsis is not specifically related to the onset of new bone formation.

11. Localised soft-tissue oedema often precedes the formation of new bone. Its appearance is undoubtedly important, but the mechanism of its origin is obscure.

12. It is not yet known what initiates ectopic ossification, what limits its spread and what finally causes it to stop.

13. We have described 100 examples of ectopic ossification in 603 paraplegic patients.

14. Surgery has been required in only eight patients. The only indication for surgery is bony ankylosis of the hip in an unacceptable position.


The Journal of Bone & Joint Surgery British Volume
Vol. 36-B, Issue 3 | Pages 368 - 374
1 Aug 1954
Hardy AG


The Journal of Bone & Joint Surgery British Volume
Vol. 35-B, Issue 4 | Pages 540 - 550
1 Nov 1953
Holdsworth FW Hardy A

1. Paraplegia from fracture-dislocation at the thoraco-lumbar junction is a mixed cord and root injury. The root damage can be distinguished from cord damage by neurological examination and by comparison of the neurological level with the fracture level.

2. Even though the cord injury is complete, as it usually is, the roots often escape or recover.

3. Fracture-dislocations can be divided into stable and unstable types. Because of the possibility of root recovery care must be taken to prevent further damage to the roots by manipulation of the spine or during treatment. For this reason unstable fracture-dislocations are fixed internally by plates.

4. Internal fixation also assists in the nursing of the patient. The nursing technique and the care of the bladder are described.


The Journal of Bone & Joint Surgery British Volume
Vol. 33-B, Issue 3 | Pages 376 - 391
1 Aug 1951
Hardy RH Clapham JC

A survey of this type cannot be used to point to any definite factor or factors predisposing to the development of hallux valgus. Nevertheless, a comparison of measurements in the morbid and control groups shows several outstanding differences:

1) There was a high degree of correlation between valgus and intermetatarsal angle in the two groups combined (coefficient, 0·7) but the correlation was higher in those cases with a degree of valgus greater than 25 degrees than in the remainder (coefficients, 0·36 and 0·53).

2) In the control group the first metatarsal was longer than tile second by a mean measure of 2 millimetres; in the morbid group by a mean measure of 4 millimetres. For a high degree of valgus and a low intermetatarsal angle the first metatarsal tends to be longer than the second by a significantly greater amount than when the high valgus is associated with iligh intermetatarsal angle.

3) In 90 per cent of the control cases there was a lateral displacement of the medial sesamoid of the first metatarsal of 3 degrees or less, whereas 88 per cent of the morbid group showed a displacement of 4 degrees or more. There was very little overlap in the distributions of this observation in the two groups. There was a high correlation between the degree of this displacement and the severity of hallux valgus.

4) Rotation of the hallux was not observed among the controls; in the morbid group those cases showing rotation had an average degree of valgus of 36 degrees while the rest had an average of 19 degrees. The mean degree of valgus in the morbid group was 32·0 degrees and that of the controls 15·5 degrees. The mean angle between the axes of the first and second metatarsals was 13·0 degrees in the morbid group and 8·5 degrees in the controls.

Since tile morbid group consisted largely of women (98 per cent) it is important to know that in the control group the only measure showing a statistically significant sex difference is that of intermetatarsal angle, but that, even so, the mean difference is only 1·3 degrees. Thus tile sex difference between the two groups is probably only of minor importance. The role of age in influencing the observations cannot be clearly elucidated from the data at present available. It can only be stated that there is no positive indication that age is a controlling factor in the departure observed in the morbid group from the control observations.