Introduction

Ankle fractures are common injuries presenting to trauma departments and ankle open reduction and internal fixation (ORIF) is one of the first procedures targeted in early orthopaedic training. Failure to address the fracture pattern with the appropriate surgical technique and hardware may lead to early failure resulting in revision procedures or premature degenerative change. Patients undergoing revision ORIF are known to be at much greater risk of complications, and many of these secondary procedures may be preventable.

Background

Several studies have shown that Staphylococcus aureus (S.aureus) nasal colonization is associated with postoperative surgical site infection and that preoperative decolonization can reduce infection rates. Up to 30% of joint replacement patients have positive S.aureus nasal swabs and patient risk factors for colonization remain largely unknown. Many joint replacement patients continue to undergo surgery without being screened.

Implant-associated infection is a major source of morbidity in orthopaedic surgery. There has been extensive research into the development of materials that prevent biofilm formation, and hence, reduce the risk of infection. Silver nanoparticle technology is receiving much interest in the field of orthopaedics for its antimicrobial properties, and the results of studies to date are encouraging. Antimicrobial effects have been seen when silver nanoparticles are used in trauma implants, tumour prostheses, bone cement, and also when combined with hydroxyapatite coatings. Although there are promising results with in vitro and in vivo studies, the number of clinical studies remains small. Future studies will be required to explore further the possible side effects associated with silver nanoparticles, to ensure their use in an effective and biocompatible manner. Here we present a review of the current literature relating to the production of nanosilver for medical use, and its orthopaedic applications.

Cite this article: Bone Joint J 2015; 97-B:582–9.

Ankle intra-articular pathology after acute injury is common and often under-diagnosed. While the majority of soft tissue injuries improve with rehabilitation, up to 40% of patients experience chronic pain, stiffness or instability. MRI is increasingly used in the investigation of such patients; however interpretation of MRI findings requires specialist expertise. The aim of this study was to determine the diagnostic potential of magnetic resonance imaging (MRI) compared to ankle arthroscopy.

Forty consecutive patients presenting with ankle pain of at least three months duration were included in the study. This cohort of patients underwent magnetic resonance imaging (MRI) and then arthroscopy.

Pre-operative MRI reported findings were compared with the arthroscopic findings. The sensitivity, specificity, positive and negative predictive value of MRI for diagnosing ankle pathology was then assessed. The 2 senior authors reviewed the MRI scans and their findings correlated.

The average time between injury and presentation to our service was 2.2 years. This interval ranged from 3 months to 10 years. 51% of patients gave history of inversion and/or plantar flexion injuries. 14 % had symptoms, which persisted following an ankle fracture. At arthroscopic evaluation 23 patients had osteochondral defects and 37 had evidence of synovitis. MRI identified 50% of the osteochondral defects with sensitivity 50% and specificity 100%. Synovitis was not identified in any of the patients on preoperative MRI but 33% of the preoperative MRI did demonstrate a joint effusion.

Despite the high rate of discordance between MR imaging and arthroscopy in our study MRI still remains a useful adjunct in the investigation of ankle pain. The implications for practice and further study are discussed.

Abstract: Plantar fasciitis is the most common cause of heel pain for which medical care is sought. It is associated with significant morbidity placing activity limitations on the patients. The response of plantar fasciitis to any treatment is unpredictable. Many different modalities of treatment are used in its management. Injection of plantar fascia with local anaesthetic and steroids under general anaesthesia was carried out in 50 patients who had a clinical diagnosis of plantar fasciitis of greater than 3 month duration. Following induction of general anesthesia, a 20-gauge needle was guided toward and into the plantar fascia. 5mls of local anaesthetic and steroid was injected into the proximal plantar fascia. The patients were followed up over a mean of 6 months. Pain intensity was graded on an 11-point visual analog scale (VAS). Questionnaires with the VAS were filled out after treatment to determine the effectiveness of the procedure. The mean pain score decreased by 5.4 points. There were no complications during or after the procedure. Patients were questioned in relation to their occupational, athletic and recreational activities pre and post the injection.

Injection of the plantar fascia under general anaesthesia is a safe and effective method for the relief of conservatively unmanageable heel pain due to plantar fasciitis. A larger patient population and a greater than 1 year follow up would be helpful to determine the long term benefits & outcomes of this treatment.

A new apparatus and technique of syndesmosis fixation is tested in a prospective clinical study. Buttons on both sides of the ankle anchor a strong suture under tension following syndesmosis reduction. This syndesmosis suture acts like a tightrope when under tension. Implantation is simple with a minimally invasive technique, as the medial side is not opened. It allows physiological micromotion whilst resisting diastasis, does not require routine removal, and allows patients to weight-bear earlier.

Sixteen patients with Weber C ankle fractures with a syndesmosis diastasis underwent suture-button fixation and the results compared to 16 consecutive patients with syndesmosis screw fixation. Patients were, in effect, quasi-randomised according to surgeon preference. Mean A,O,F,A,S, ankle scores were significantly better in the suture-button group at three months post-op (91 vs 80, p=0.01, unpaired t-test) and at twelve months (93 vs 83, p=0.04, unpaired t-test). Return to work was also significantly faster (2.6 months vs 4.6 months, p=0.02, unpaired t-test). No suture-buttons required implant removal. Axial CT scanning at three months showed implants to be intact with maintenance of reduction, as compared to the uninjured contralateral side.

Suture-button syndesmosis fixation is simple, safe and effective. It has shown improved outcomes and faster rehabilitation, without needing routine removal. Although the apparatus design may undergo further refinement, we believe this technique will become the treatment of choice in Weber C ankle fractures with a syndesmosis injury.

Aim: To compare the outcome of open reduction and internal fixation with MUA and k-wire stabilisation of dorsally displaced distal radial fractures

Methods: A review of patients that had ORIF or MUA and k-wire stabilisation for dorsally displaced distal radial fractures was carried out and patients with a follow period of more than 6 months were selected for this study. The patient history and the management of the injury were obtained and the wrist examined. Each patient completed a patient-rated wrist evaluation form and the range of movement and strength of the wrist was determined by the senior occupational therapist. Standard radiographs were obtained and volar tilt, radial inclination and radial length were measured.

Results: This study provides results on 24 patients, which were grouped according to the two different surgical procedures; ORIF and MUA and k-wire stabilisation. The procedure undertaken depended on consultant preferences and in the majority of cases patients were treated with MUA and k-wire stabilisation. Patients of both groups were of similar age and all sustained either a low or medium energy injury. All patients from each group received physiotherapy post operatively.

There was no significant difference between both groups for range of movement and grip strength. There was also no difference between the patient’s perception of pain and function which was assessed using the patient rated wrist evaluation (PRWE). Radiologically, the k-wire stabilisation group averaged better volar tilt compared with the ORIF group. For radial height and inclination the outcome was similar.

Conclusion: MUA and k-wire stabilisation has been the most popular surgical management for unstable dorsally displaced fractures of the distal radius. More recently ORIF with the locking compression plate has been used with good results. This study showed that the outcome of ORIF and MUA and k-wire stabilisation were similar and therefore either surgical management can be used with good results.

Study Design: A retrospective review of the functional outcome of neurologically intact patients with burst fractures of the first lumbar vertebra.

Objective: To assess the functional outcome of patients treated either surgically or conservatively following burst fractures of L1.

Methods: A retrospective review of 38 neurologically intact patients with burst fractures of L1 was performed. Follow-up clinical evaluation was obtained from 26 patients, eleven of whom were treated surgically and fifteen of whom were managed conservatively. Patients were assessed with regard to pain, employment status, ability to partake in recreational activities and their overall satisfaction with treatment. Radiographic evaluation of anterior body compression and vertebral kyphosis was performed at the time of injury. Computed tomography scanning of spinal canal compromise was also recorded at the time of injury. Subsequent recordings of vertebral kyphosis were assessed at the time of remobilisation and at 3-month follow-up evaluation.

Results: Mean follow-up time for the 26 patients was 43.02 months. At final clinical follow-up of the fifteen patients managed conservatively, 6 patients (40%) had little or no pain; 12 patients (80%) had returned to work with 6 (40%) stating that they had little or no restrictions in their ability to work; 8 patients (53%) had returned to the same level of recreational activity as prior to their injury with 7 (47%) stating they had little or no restrictions in their ability to participate in recreational activities. One patient (9%) reported being very dissatisfied with the operative treatment of their spine fracture.

No correlation was found between kyphotic deformity, extent of canal compromise and clinical outcome.

Conclusions: Non-operative management of burst fractures of the first lumbar vertebra is a very safe and effective method of treatment. It reduces hospitalisation time and avoids the costs and risk of surgery. Patients return to the functional activities of daily living quickly and have a better clinical outcome when compared with operative management.

Study Design: The effects of heat on porcine intertvertebral disc were studied experimentally.

Objective: To assess the effects of in-vitro heating of porcine nucleus pulposus on expression of inducible heat shock protein 70 and subsequent modification of biochemical responses to an inflammatory insult in the heated intervertebral disc tissue.

Subjects: Lumbar spines were harvested from six pigs. The nucleus pulposus was dissected from each intervertebral disc, divided into control (37°C) and heat shocked (42°C) groups then cultured in medium for one hour. All samples were then cultured at 37 C for a further two hours. After three hours tissue and supernatant were harvested from one third of the samples and the expression of inducible heat shock protein 70 (HSP70) was quantified via Western immunoblotting and enzyme linked immuno-sorbent assay (ELISA). The remaining samples were cultured either in normal medium or altered (pro-inflammatory) medium containing 5ug/ml bacterial lipopolysaccharide (LPS). At 24 hours the supernatant from these samples was analysed for both interleukin-8 (IL-8) and prostaglandin E2 (PGE2) secretion using ELISA.

Outcome Measures: Western immunoblotting and enzyme linked immuno-sorbent assay (ELISA) for heat shock protein 70. ELISA for interleukin-8 (IL-8) and prostaglandin E2 (PGE2).

Results: HSP70 expression was significantly increased in the heat shocked specimens. IL-8 and PGE2 secretion were significantly increased in nucleus pulposus exposed to LPS at both temperatures. The concentrations of IL-8 and PGE2 secreted in the heat shocked samples were significantly less than controls, particularly after exposure to LPS (p< 0.05, paired students t test).

Conclusions: In vitro heating of porcine nucleus pulposus causes overexpression of HSP70. This heat shock effect can alter aspects of the biochemical response of the intervertebral disc tissue to an inflammatory insult. Intradiscal electrothermal therapy (IDET) may, in theory, reduce discogenic pain at temperatures as low as 42°C by generating similar heat-induced changes in the nuclear biochemistry of degenerate intervertebral discs.

Introduction A new technique of ankle syndesmosis fixation is proposed. Buttons are placed on both sides of the ankle, connected by a strong non-absorbable suture. The technique is simple and minimally invasive: a medial incision is not required. It resists diastasis whilst allowing physiological micromotion and does not require routine removal.

Methods The technique was tested on a cadaver model of a Maisonneuve injury under increasing torque loads. Sixteen embalmed cadaver legs were randomised to receive suture-button fixation or four-cortical 4.5 mm syndesmosis screw fixation. A prospective clinical study involving 16 patients with Weber C fractures and syndesmosis diastasis is presented. They underwent suture-button fixation and the results were compared to 16 consecutive patients with syndesmosis screw fixation.

Results In the cadaver study, both groups had similar rates of diastasis following torque loading. However, the suture-button did give a more consistent performance: standard deviations were significantly lower (p=0.001) than the screw group. In the clinical study, both groups were evenly matched as regards patient age, male: female ratio, and fracture patterns. Mean AOFAS ankle outcome scores at three months were significantly better in the suture-button group (91 versus 82, p=0.01). No suture-button patients required implant removal. They had a faster return to work compared to the screw group (three months versus five months). Axial CT scanning performed at three months post-op showed all implants to be intact with no loss of reduction.

Conclusions Suture-button syndesmosis fixation is simple, safe, effective and physiological. It has shown improved outcomes and faster rehabilitation, without needing routine removal. It may become the treatment of choice in Weber C ankle fractures with a syndesmosis diastasis.

In relation to the conduct of this study, one or more the authors have received, or are likely to receive direct material benefits.

Aims: A new technique of syndesmosis fixation is proposed; placing buttons on both sides of the ankle, without opening the medial side, connected by a strong non-absorbable suture. We tested this against syndesmosis screw fixation in a cadaver model of a Maisonneuve injury and subsequently in a prospective clinical study. Methods: 16 cadaver legs were randomised to have suture-button or syndesmosis screw fixation and tested under torque loading. In the clinical study, 16 patients with a syndesmosis diastasis underwent suturebutton fixation and the results compared to 16 patients with syndesmosis screw fixation. Results: In the cadaver study, both groups had similar rates of diastasis, although the suture-button did give a more consistent performance: standard deviations were significantly lower (p=0.001). In the clinical study, mean A.O.F.A.S. scores at 3 months were significantly better in the suturebutton group (91 vs 82, p=0.01). No suture-button implants required removal, compared to 13/16 of the screw group (p=0.001). Conclusions: Suture-button syndesmosis fixation is simple, safe and physiological. Biomechanically it performs at least as well as screw fixation. Clinically it has shown improved outcomes, without needing routine removal. It may become the treatment of choice in syndesmosis injuries.