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Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_15 | Pages 4 - 4
1 Dec 2021
DOUBLE-DOSE CEFUROXIME CONCENTRATIONS IN BONE, SYNOVIAL FLUID OF THE KNEE JOINT, AND SUBCUTANEOUS ADIPOSE TISSUE: A RANDOMIZED PORCINE MICRODIALYSIS STUDY
J⊘rgensen AR Hanberg P Bue M Thomassen MB J⊘rgensen N Stilling M
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Aim

This study evaluated target tissue concentrations of double dose cefuroxime administered intravenously as either one 15 min infusion of 3,000 mg (Group 1) or two single 15 min infusions of 1,500 mg administered 4 h apart (Group 2).

Method

Sixteen pigs were randomised into two groups of eight. Cortical and cancellous bone, synovial fluid of the knee joint and subcutaneous adipose tissue concentrations were measured based on sampling via microdialysis. Plasma samples were collected as a reference. Comparison of the groups was based on time with concentrations above relevant minimal inhibitory concentrations (fT>MIC) of 4 μg/mL.