Breast cancer survivors have known risk factors that might influence the results of total hip arthroplasty (THA) or total knee arthroplasty (TKA). This study evaluated clinical outcomes of patients with breast cancer history after primary THA and TKA. Our total joint registry identified patients with breast cancer history undergoing primary THA (n = 423) and TKA (n = 540). Patients were matched 1:1 based upon age, sex, BMI, procedure (hip or knee), and surgical year to non-breast cancer controls. Mortality, implant survival, and complications were assessed via Kaplan-Meier methods. Clinical outcomes were evaluated via Harris Hip Scores (HHSs) or Knee Society Scores (KSSs). Mean follow-up was six years (2 to 15).Aims
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Prophylactic antibiotics are important in reducing the risk of periprosthetic joint infection (PJI) following total knee arthroplasty. Their effectiveness depends on the choice of antibiotic and the optimum timing of their administration, to ensure adequate tissue concentrations. Cephalosporins are typically used, but an increasing number of resistant organisms are causing PJI, leading to the additional use of vancomycin. There are difficulties, however, with the systemic administration of vancomycin including its optimal timing, due to the need for prolonged administration, and potential adverse reactions. Intraosseous regional administration distal to a tourniquet is an alternative and attractive mode of delivery due to the ease of obtaining intraosseous access. Many authors have reported the effectiveness of intraosseous prophylaxis in achieving higher concentrations of antibiotic in the tissues compared with intravenous administration, providing equal or enhanced prophylaxis while minimizing adverse effects. This annotation describes the technique of intraosseous administration of antibiotics and summarizes the relevant clinical literature to date. Cite this article:
Intraosseous administration of low dose vancomycin has been proven to produce 6 to 20 times higher tissue concentrations compared to intravenous administration in both primary and revision knee replacement. However, these superior levels are achieved when the antibiotic given intraosseously is administered distal to a tourniquet that is inflated for the majority of the case. With increasing interest in limited, or no, tourniquet use during TKA we sought to study the tissue concentrations achieved with limited tourniquet use and intraosseously administered vancomycin compared to weight-based, time optimized intravenous administration. Twenty-four patients undergoing primary TKA were randomized to two groups. The Intravenous (IV) Group received weight based (15mg/kg) vancomycin timed to finish before incision. The Intraosseous (IO) Group received 500 mg of vancomycin injected as a bolus through a needle into the proximal tibia distal to an inflated tourniquet prior to skin incision. In the IO group, the tourniquet was deflated 10 minutes following the injection and re-inflated only for cementation. In the IV group, the tourniquet was only inflated for cementation. During the procedure, fat and bone samples were taken at regular intervals. Tissue antibiotic concentrations were measured using a validated technique involving high performance liquid chromatography.Introduction
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Tibial component malrotation is associated with pain, stiffness and altered patellofemoral kinematics in total knee arthroplasty (TKA). However, accurately measuring tibial component rotation following TKA is difficult. Proposed protocols utilizing computed tomography (CT) are not well validated and can be time consuming. This study aimed to; 1) Validate and compare the reproducibility of the Berger (2D-CT) and Mayo (3D-CT) protocols; 2) Validate a simple, and potentially rapid screening measurement using an anatomical distance on 2D axial CT- the Centre of Tibial Tray to Tibial Tubercle (CTTT) distance. Rotational alignment of 70 TKA patients were evaluated by 3 independent observers using the Berger, and Mayo protocols, which have been previously described, and a new CTTT protocol (Figure 1). The inter and intra-rater interclass correlation coefficients (ICC's), mean difference between measurements and the mean measurement times were calculated. Linear regression analysis was performed to give a coefficient of determination (R2).Introduction
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Patellar resurfacing during Total Knee Arthroplasty (TKA) is controversial. Problems unique to patellar resurfacing may be influenced by available patellar component design. These issues include; over-stuffing (the creation of a composite patellar-prosthesis thickness greater than the native patella) that may contribute to reduced range of motion; and over-resection of the native patellar bone that may contribute to post-operative fracture. Prosthesis design may play a role in contributing to these problems. Component diameter and thickness are quite variable from one manufacturer to another and little information has been previously published about optimal component dimensions. This anatomic study was performed to define the native patellar anatomy of patients undergoing TKA, in order to guide future component design. This retrospective, IRB approved study reviewed 797 Caucasian knees that underwent primary TKA by a single surgeon. Data recorded for each patient included: gender; patellar thickness before and after resurfacing, and the size of the component that provided the greatest patellar coverage without any overhang. The residual patellar bone thickness after resection was also calculated.Introduction
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Opponents of patellar resurfacing during Total Knee Arthroplasty (TKA) note unique complications associated with resurfacing. Problems include over-stuffing (the creation of a composite patellar-prosthesis thickness greater than the native patella) that may contribute to reduced range of motion; and creation of a patellar remnant that is too thin (in order to avoid over-stuffing) that may contribute to post-operative fracture. Factors including surgical technique, prosthesis design and patient anatomy may contribute to these problems. This study was performed to define the native patellar anatomy, and to compare the effect of differences in component thickness between manufacturers. This retrospective, IRB approved study reviewed 803 knees that underwent primary TKA between 2005 and 2011 with a single surgeon. Patellar resurfacing was performed with a round, polyethylene component from one of two different implant designs using the same surgical technique. Data recorded for each patient included: gender; patellar thickness before and after resurfacing; the dimensions and manufacturer of the prosthesis. The residual patellar bone thickness after resection was calculated.Introduction
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