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The Bone & Joint Journal
Vol. 99-B, Issue 9 | Pages 1250 - 1255
1 Sep 2017
Talbot C Adam J Paton R

Aims

Despite the presence of screening programmes, infants continue to present with late developmental dysplasia of the hip (DDH), the impact of which is significant. The aim of this study was to assess infants with late presenting dislocation of the hip despite universal clinical neonatal and selective ultrasound screening.

Patients and Methods

Between 01 January 1997 to 31 December 2011, a prospective, longitudinal study was undertaken of a cohort of 64 670 live births. Late presenting dislocation was defined as presentation after three months of age. Diagnosis was confirmed by ultrasound and plain radiography. Patient demographics, referral type, reason for referral, risk factors (breech presentation/strong family history) and clinical and radiological findings were recorded.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_11 | Pages 5 - 5
1 Jun 2017
Nie K Rymaruk S Paton R
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Purpose

This 20-year prospective longitudinal observational study aims to determine the incidence of pathological developmental dysplasia of the hip (DDH) in children referred with clicky hips and define the risk posed to inform neonatal hip screening programmes including the role of ultrasound.

Method

355 children from 1997 to 2016 were referred with clicky hips to our “one stop” paediatric hip clinic under the local neonatal hip screening programme. Hips were assessed clinically for instability and by ultrasound using a simplified Graf classification. Dislocated or dislocatable hips were classed as Graf type IV.


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Purpose

To clarify the true association with pathological DDH and ASC (asymmetrical skin crease).

Method

Between 1st January 1995 and 31st December 2015 all paediatric referrals with suspected hip instability were assessed in a one-stop DDH clinic. All patients had clinical and sonographic assessment with results prospectively recorded onto a database.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_11 | Pages 8 - 8
1 Jun 2017
Rymaruk S Rashed R Nie K Choudry Q Paton R
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Purpose

There is concern that the positive predictive value (PPV) of neonatal screening for instability may have deteriorated over recent years, this study aims to evaluate this.

Method

This is a prospective observational longitudinal study from 2012 – 2016. Patients that were referred from paediatric neonatal screening with hip instability (Ortolani / Barlow positive, clunks) were identified and underwent ultrasound and clinical examination in the one stop hip clinic by the senior author. Referrals were taken from a range of screeners from paediatric doctors to midwives and advanced neonatal practitioners. Syndromic or neurological dislocated hips were excluded. The outcome measures were the presence of a subluxated / dislocated hip on ultrasound as per Graf and Harcke classification and a positive provocative manoeuvre on examination. This allowed a PPV to be evaluated for both ultrasound and clinical examination.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_15 | Pages 5 - 6
1 Sep 2016
Davies R Mace J Talbot C Paton R
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The aim was to assess the value of the GP 6–8 week hip examination.

In a 15-year prospective observational longitudinal cohort study, every infant referred by the GP with suspected pathological developmental dysplasia of the hip (DDH) had their hip joints clinically and sonographically examined in a specialist hip screening clinic. Graf Type IV and dislocated hips were classified as pathological. Screening failures were defined as those who had not been identified by the 6–8 week check and presented with late instability. Secondary univariate and multivariable analysis was performed to determine which clinical findings are predictive of instability.

64,518 infants underwent the 6–8 week GP check. Of 176 referrals, 5 had pathological hips. 13 screening failures, presented between the ages of 17 and 80 weeks. The 6–8 week check has a sensitivity of 28% and a specificity of 99.7%.

Univariate analysis revealed positive Ortolani tests and patients referred as ‘unstable hip’ to be significant predictors of hip pathology. Clicky hips, asymmetric skin creases, and leg length inequality were not predictive of pathological hips. A multivariable model showed a positive Ortolani test to be the sole independent predictor of instability at 6–8 weeks.

This is the first attempt to test the validity of the 6–8 week GP clinical hip check. A low rate of hip pathology was identified. The high rate of false negatives raises questions about the value of screening at this age. At 6–8 weeks, clinical signs of hip instability are unreliable as hips become irreducible and stiff.

Based on our findings, we recommend that at 6–8 weeks, referrals are only made if the Ortolani test is positive. We advocate the reintroduction of the 8-month check, including an assessment for limited hip abduction, which may improve the detection rate of those missed by initial screening.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_1 | Pages 3 - 3
1 Jan 2014
Hughes S Jugdey R Choudry Q Paton R
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Aim:

An assessment of the relationship between pathological Developmental Dysplasia of the Hip (DDH) and Congenital Talipes Equinovarus (CTEV).

Introduction:

Traditional UK guidelines consider abnormalities of the foot to be a risk factor for DDH1,2. Currently, there is controversy whether congenital foot abnormalities are true risk factors for pathological DDH3,4. There is a relationship between CTCV and hip dysplasia though the relationship between CTEV and pathological DDH is less clear5. In a previous 11 year prospective longitudinal study no case of Graf Types III, IV or irreducible hip dislocation were associated with CTEV5. Subsequent correspondence and case histories have challenged this view6


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_6 | Pages 8 - 8
1 Feb 2013
Foley G Wadia F Yates E Paton R
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Aim

Assess the incidence of Vitamin D deficiency from a cohort of new referrals to a general Paediatric Orthopaedic outpatient clinic and evaluate the relationship between Vitamin D deficiency and the diagnosis of radiological or biochemical nutritional rickets.

Methods

We performed a retrospective case note and biochemistry database review of all new patients seen in an elective Paediatric Orthopaedic clinic in the year 2010, who had Vitamin D levels measured. Radiographs were reviewed by the senior author to determine the presence or absence of radiological rickets. Biochemical rickets was diagnosed if there was deficient Vitamin D (< 20 mcg/ml) and raised PTH.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VI | Pages 10 - 10
1 Mar 2012
Boden R Paton R
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Purpose of study

The results clinically & statistically of a 14 year longitudinal study comparing the traditional ‘stretch & strap’ method (1994-2002) with the Ponseti technique (2002-2008)

Methods & Results

A 14 year prospective longitudinal comparative study was undertaken into management and outcome of CTEV. There were 114 feet (80 patients), 64 feet (45 patients) treated traditionally and 50 feet (35 Patients) with the Ponseti technique. Patient demographics, the Harold & Walker Classification, and associated risk factors for CTEV were analysed. If conservative treatment failed a radical sub-talar release operation (RSR) was undertaken.

The incidence of fixed CTEV was 1.6 per 1000 live births with a male to female ratio of 2.8 to 1. Idiopathic CTEV was present in 77.5% of patients, (22.5% with a primary aetiology). Mean time to RSR was comparable: 37.43 weeks (CI: 33.65 to 41.21) and 46 weeks (CI: 39.18 to 52.82) for the traditional and Ponseti groups respectively. In the traditional group 65.6% (CI: 53.4 to 76.1%) of feet underwent RSR surgery compared to just 25.5% (CI: 15.8 to 38.3%) in the Ponseti group, When idiopathic CTEV was analysed separately these rates reduce to 56.5% (CI: 42.3 to 69.8%) and 15.8% (CI: 7.4 to 30.4%) respectively. The Relative Risk of requiring RSR surgery in traditional compared to Ponseti groups was 2.58 (CI: 1.59 to 4.19) for all patients and 3.58 (CI: 1.65 to 7.78) for idiopathic CTEV (statistically significant). The results of the Ponseti method improved with time suggesting a learning curve.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VI | Pages 3 - 3
1 Mar 2012
Paton R
Full Access

Purpose of study

Results clinically & statistically of a 10 year prospective observational longitudinal study of the effects of sonographic screening for ‘risk’ factors in DDH.

Methods & Results

From 1997 to 2006 the project analysed the results of a sonographic screening programme for clinical instability & ‘risk factors’ in Blackburn (modified Graf system). ‘Risk factors’ included: breech presentation, strong family history, foot deformities & oligohydramnios. Statistically 95% confidence intervals, relative risk, sensitivity, specificity PPV & NPV were calculated. The outcome measure was irreducible dislocation of the hip joint. There was a birth population of 37,510, of which 2693 were ‘at risk’ & 132 clinically unstable.

Three subsections:

1. Clinically unstable hips (birth) 2 irreducible dislocations
2. ‘At risk’ 6 irreducible dislocations
3. Secondary referral (GP screening) 11 irreducible dislocations

The overall irreducible dislocation rate was 0.51 per 1000 live births.

‘Risk factors’: mGraf Type III/IV/ Irreducible:

CTCV: 1: 13.8 RR = 26.5
Family history: 1:18.5 RR = 23.3
Breech: 1:35 RR = 14.8
Oligohydramnios 1:99.5
TEV (postural) 1:202
CTEV (fixed) 0.0

Narrow 95% CI for Breech, CTCV & CTEV

Wide 95% CI for Family history, oligohydramnios & TEV (postural)

95% CI (RR) for Oligohydramnios & TEV not significant.

RR for clinical hip instability was 983.6

Percentage female

18/19 irreducible hips 94.74%
64/92 Type IV hips 69.56%
26/30 Type III hips 86.66%

34.15% of clinically unstable hip joints had a ‘risk factor’