Advertisement for orthosearch.org.uk
Results 1 - 7 of 7
Results per page:
Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 19 - 19
1 Apr 2013
Harada N Watanabe Y Abe S Sato K Yamanaka K Sakai Y Kaneko T Matsushita T
Full Access

Purpose

The purpose of this study was to evaluate the effects of implantation of mesenchymal stem cell derived condrogenic cells (MSC-DC) on bone healing in segmental defects in rat femur.

Methods

Five-millimeter segmental bone defects were produced in the mid-shaft of the femur of Fisher 344 rats and stabilized with external fixator. The Treatment Group received MSC-DC, seeded on a PLGA scaffold, locally at the site of the bone defect, and Control Group received scaffold only. The healing processes were monitored radiographically (Softex), and studied radiographically (Micro-CT) and histologically.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 65 - 65
1 Apr 2013
Watanabe Y Takenaka N Kobayashi M Matsushita T
Full Access

Objective

To investigate the outcomes of patients following the chipping procedures as an alternative to bone grafting in treatment of non-unions after long bone fracture.

Patients

Sixteen patients with femoral or tibial non-union were included. The median follow-up was 24 months.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 83 - 83
1 Apr 2013
Sato K Watanabe Y Abe S Harada N Yamanaka K Sakai Y Kaneko T Matsushita T
Full Access

Introduction

what size of defect is optimal for creating an atrophic nonunion animal model has not been well defined. Our aim in this study was to establish a clinically relevant model of atrophic nonunion in rat femur by creation of a bone defect to research fracture healing and nonunion.

Materials and methods

We used 30 male Fischer 344 rats (aged 10–11 weeks), which were equally divided into six groups. The segmental bone defects to a single femur in each rat were performed by double transverse osteotomy, and different sized defects were created by group for each group (1 mm, 2 mm, 3 mm, 4 mm, 5 mm and 6 mm). The defects were measured and maintained strictly by using an original external fixator. The periosteum for each defect was stripped both proximally and distally. Thereafter, these models were evaluated by radiology and histology. Radiographs were taken at baseline and at intervals of two weeks over a period of 8 weeks. Atrophic nonunion was defined as a lack of continuity and atrophy of both defect ends radiologically and histologically at eight weeks.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 35 - 35
1 Apr 2013
Sato K Watanabe Y Abe S Harada N Yamanaka K Sakai Y Kaneko T Matsushita T
Full Access

Reconstruction of 10mm segmental bone defects in rat by mesenchymal stem cell derived chondrogenic cells (MSC-DC)

Background

Mesenchymal stem cell derived condrogenic cells (MSC-DC) have excellent potential for healing 5 mm bone defect in rat femur.

Purpose

To evaluate the effectiveness of MSC-DC on bone healing in 10 mm segmental bone defects in rat femur.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 30 - 30
1 Apr 2013
Watanabe Y Arai Y Takenaka N Kobayashi M Matsushita T
Full Access

Objective

To determine what factors affect fracture healing with low-intensity pulsed ultrasound (LIPUS) for delayed unions and nonunions.

Patients

A consecutive cohort of 101 delayed unions and 50 nonunions after long bone fractures treated with LIPUS between May 1998 and April 2007.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 36 - 36
1 Apr 2013
Matsui K Miyamoto W Tsuchida Y Takao M Matsushita T
Full Access

Background

Growing of the geriatric population has brought about increase of lower extremity fractures. The purpose of this study was to investigate the occurrence of surgical site infection after the surgery for lower extremity fractures, except proximal femoral fracture, in over eighty years old patients.

Methods

Patients with closed lower extremity fracture which were treated surgically in 2011 were divided into two groups (Group O; the equal or more than 80 years old, Group Y; from 20 to 65 years old), and the incidence of infection and the outcome after its treatment was compared between Group O and Group Y.


The Journal of Bone & Joint Surgery British Volume
Vol. 78-B, Issue 5 | Pages 718 - 721
1 Sep 1996
Hung S Kurokawa T Nakamura K Matsushita T Shiro R Okazaki H

Femoral lengthening has been associated with narrowing of the joint space at the hip. We have studied the joint space before lengthening in 20 patients with a short femur due to a femoral-shaft fracture (15) or distal femoral epiphyseal injury (5). Their mean age at injury was 16 years (3 to 27) and the mean shortening was 5.4 cm (1.1 to 14).

We found that the hip joint space of the shortened femur was significantly narrower (p < 0.001) than that on the normal side, with a mean narrowing ratio of 15.5% (−5 to +43). The narrowing ratio was directly related to the period spent non-weight-bearing (p < 0.001), but not to the amount of femoral shortening.

We have shown that the joint space of the hip in patients with post-traumatic femoral shortening was narrowed even before femoral lengthening had been started.