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Bone & Joint Open
Vol. 4, Issue 11 | Pages 899 - 905
24 Nov 2023
Orfanos G Nantha Kumar N Redfern D Burston B Banerjee R Thomas G

Aims

We aim to evaluate the usefulness of postoperative blood tests by investigating the incidence of abnormal results following total joint replacement (TJR), as well as identifying preoperative risk factors for abnormal blood test results postoperatively, especially pertaining to anaemia and acute kidney injury (AKI).

Methods

This is a retrospective cohort study of patients who had elective TJR between January and December 2019 at a tertiary centre. Data gathered included age at time of surgery, sex, BMI, American Society of Anesthesiologists (ASA) grade, preoperative and postoperative laboratory test results, haemoglobin (Hgb), white blood count (WBC), haematocrit (Hct), platelets (Plts), sodium (Na+), potassium (K+), creatinine (Cr), estimated glomerular filtration rate (eGFR), and Ferritin (ug/l). Abnormal blood tests, AKI, electrolyte imbalance, anaemia, transfusion, reoperation, and readmission within one year were reported.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_1 | Pages 29 - 29
1 Jan 2022
Awadallah M Ong J Kumar N Rajata P Parker M
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Abstract

Background

Dislocation of a hip hemiarthroplasty is a devastating complication with a high mortality rate in elderly patients. Previous studies have suggested a higher dislocation rate in patients with neuromuscular conditions. In this study, we have reviewed our larger cohort of patients to identify whether there is any association between neuromuscular disorders and prosthetic dislocation in patients treated with hip hemiarthroplasty for femoral neck fractures.

Patients and Methods

Our study is a retrospective analysis of data collected over 34 years for patients with intracapsular neck of femur fracture who underwent hip hemiarthroplasty. The study population is composed of four groups: patients with no neuromuscular disorders, patients with Parkinson's disease, patients with previous stroke, and patients with dementia.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_13 | Pages 65 - 65
1 Nov 2021
Awadallah M Ong J Kumar N Rajata P Parker M
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Introduction and Objective

Dislocation of a hip hemiarthroplasty is a significant complication with a high mortality rate in elderly patients. Previous studies have shown a higher risk of dislocation in patients with neuromuscular conditions. In this study, we reviewed our larger cohort of patients to identify if there is a link between neuromuscular disorders and dislocation of hip hemiarthroplasty in patients with neuromuscular conditions.

Materials and Methods

We have retrospectively analysed a single-centre data that was collected over 34 years for patients with intracapsular neck of femur fracture who underwent hip hemiarthroplasty. The study population was composed of four groups: patients with no neuromuscular disorders, patients with Parkinson's disease, patients with previous stroke, and patients with mental impairment.


The Bone & Joint Journal
Vol. 102-B, Issue 9 | Pages 1113 - 1121
14 Sep 2020
Nantha Kumar N Kunutsor SK Fernandez MA Dominguez E Parsons N Costa ML Whitehouse MR

Aims

We conducted a systematic review and meta-analysis to compare the mortality, morbidity, and functional outcomes of cemented versus uncemented hemiarthroplasty in the treatment of intracapsular hip fractures, analyzing contemporary and non-contemporary implants separately.

Methods

PubMed, Medline, EMBASE, CINAHL, and Cochrane Library were searched to 2 February 2020 for randomized controlled trials (RCTs) comparing the primary outcome, mortality, and secondary outcomes of function, quality of life, reoperation, postoperative complications, perioperative outcomes, pain, and length of hospital stay. Relative risks (RRs) and mean differences (with 95% confidence intervals (CIs)) were used as summary association measures.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_10 | Pages 42 - 42
1 May 2016
Singh S Yadav C Kumar A Kumar N
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Introduction

To reduce several disadvantages many surgeons are not using tourniquet in TKA. Here we compared functional outcome along with pain and blood loss in sixty patients.

Material and Method

60 patients who underwent TKA wererandomized into a tourniquet group (n2 = 30) and a non-tourniquet group (n1 = 30). All operations were performed by the samesurgeon and follow-up was for 6 month. Primary outcomes werefunctional and clinical outcomes, as evaluated by KSS and postoperative pain. Secondary outcomes were blood loss, surgical time and visibility, extensor lag and Knee ROM, DVT and radiolucency.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 312 - 312
1 Jul 2014
Malhotra R Kumar N Wu P Zaw A Liu G Thambiah J Wong H
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Summary

Metastatic spinal disease is a common entity of much debate in terms of ideal surgical treatment. The introduction of MIS can be a game-changer in the treatment of MSD due to less peri-operative morbidity and allowing earlier radiotherapy and/or chemotherapy.

Introduction

Less invasive techniques have always been welcome for management of patients with ‘Metastatic Spinal Disorders’. This is because these patients can be poor candidates for extensive / major invasive surgery even though radiologically, there may be an indication for one. The aim of the treatment with Minimal Invasive Fixation (MIS) systems is mainly for ‘pain relief’ than to radically decrease tumour burden or to achieve near total spinal cord decompression, which could be major presentations in these patients. These procedures address the ‘spinal instability’ very well and they can address pain associated with compression fractures resulting from metastatic disease from a solid organ as well as multiple myeloma with minimal complications. These procedures can be combined with radiology and chemotherapy without much concern for wound problems in the way of infection or dehiscence. They also have a great advantage of timing of adjunct therapy closer to the index procedure. The disadvantage, however, are they do not allow thorough decompression of the spinal cord. There could also be problem in addressing patients who have severe vertebral height loss or loss of integrity of the anterior column where anterior column reconstruction may be required. There is a risk of inadequate fixation or implant loosening or failure. We aim to examine the results of MIS surgery in our department and support the rationale for its use.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 310 - 310
1 Jul 2014
Kumar N Chen Y Ahmed Q Lee V Wong H
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Summary

This is the first ever study to report the successful elimination of malignant cells from salvaged blood obtained during metastatic spine tumour surgery using a leucocyte depletion filter.

Introduction

Catastrophic bleeding is a significant problem in metastatic spine tumour surgery (MSTS). However, intaoperative cell salvage (IOCS) has traditionally been contraindicated in tumour surgery because of the theoretical concern of promoting tumour dissemination by re-infusing tumour cells into the circulation. Although IOCS has been extensively investigated in patients undergoing surgery for gynaecological, lung, urological, gastrointestinal, and hepatobiliary cancers, to date, there is no prior report of the use of IOCS in MSTS. We conducted a prospective observational study to evaluate whether LDF can eliminate tumour cells from blood salvaged during MSTS.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 309 - 309
1 Jul 2014
Chen Y Tai B Nayak D Kumar N Goy R Wong H
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Summary

Our meta-analysis showed that pooled mean blood loss during spinal tumour surgeries was 2180 ml. Standardised methods of calculating and reporting intra-operative blood loss are needed as it would be beneficial in the pre-operative planning of blood replenishment during surgery.

Introduction

The vertebral column is the commonest site of bony metastasis, accounting for 18,000 new cases in North America yearly. Patients with spinal metastasis are often elderly, have compromised cardiovascular status, poor physiological reserve and altered immune status, all of which render them more susceptible to the complications of intra-operative blood loss and associated transfusion. Currently no consensus exists regarding the expected volume of blood lost during metastatic spine tumour surgery with various papers quoting anywhere between 1L to 6L. Knowledge of the expected blood loss prior to surgery however is important as it facilitates pre-operative planning, intra- and post-operative management of fluid balance and blood transfusion. We conducted a meta-analysis of published literature on spine tumour surgery to answer the question: “What is the expected blood loss in major spinal tumour surgery for metastatic spinal disease?”


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 311 - 311
1 Jul 2014
Kumar N Chen Y Zaw A Ahmed Q Soong R Nayak D Wong H
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Summary

There is emerging evidence of successful application of IOCS and leucocyte depletion filter in removing tumour cells from blood salvaged during various oncological surgeries. Research on the use of IOCS-LDF in MSTS is urgently needed.

Introduction

Intra-operative cell salvage (IOCS) can reduce allogeneic blood transfusion requirements in non-tumour related spinal surgery. However, IOCS is deemed contraindicated in metastatic spine tumor surgery (MSTS) due to risk of tumour dissemination. Evidence is emerging from different surgical specialties describing the use of IOCS in cancer surgery. We wanted to investigate if IOCS is really contraindicated in MSTS. We hereby present a systematic literature review to answer the following questions: 1. Has IOCS ever been used in MSTS? 2. Is there any evidence to support the use of IOCS in other oncologic surgeries?


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 313 - 313
1 Jul 2014
Tan J Lim J Chen Y Kumar N
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Summary

Neurological deficits resulting from spinal cord compression occur infrequently. When presented with neurological compromise, the most common management was radiotherapy, with surgery only being offered to patients who developed neurological deficit or pathological fracture resulting in unresolved severe pain post radiotherapy.

Introduction

Nasopharyngeal carcinoma has been reported to have a higher incidence of distant metastases to the spine. This study was conducted to evaluate the incidence, presentation and management of neurological involvement related to spinal metastasis from nasopharyngeal carcinoma.


The Bone & Joint Journal
Vol. 95-B, Issue 5 | Pages 683 - 688
1 May 2013
Chen Y Tai BC Nayak D Kumar N Chua KH Lim JW Goy RWL Wong HK

There is currently no consensus about the mean volume of blood lost during spinal tumour surgery and surgery for metastatic spinal disease. We conducted a systematic review of papers published in the English language between 31 January 1992 and 31 January 2012. Only papers that clearly presented blood loss data in spinal surgery for metastatic disease were included. The random effects model was used to obtain the pooled estimate of mean blood loss.

We selected 18 papers, including six case series, ten retrospective reviews and two prospective studies. Altogether, there were 760 patients who had undergone spinal tumour surgery and surgery for metastatic spinal disease. The pooled estimate of peri-operative blood loss was 2180 ml (95% confidence interval 1805 to 2554) with catastrophic blood loss as high as 5000 ml, which is rare. Aside from two studies that reported large amounts of mean blood loss (> 5500 ml), the resulting funnel plot suggested an absence of publication bias. This was confirmed by Egger’s test, which did not show any small-study effects (p = 0.119). However, there was strong evidence of heterogeneity between studies (I2 = 90%; p < 0.001).

Spinal surgery for metastatic disease is associated with significant blood loss and the possibility of catastrophic blood loss. There is a need to establish standardised methods of calculating and reporting this blood loss. Analysis should include assessment by area of the spine, primary pathology and nature of surgery so that the amount of blood loss can be predicted. Consideration should be given to autotransfusion in these patients.

Cite this article: Bone Joint J 2013;95-B:683–8.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_X | Pages 111 - 111
1 Apr 2012
Kumar N Das S Nath C Wong HK
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Patients with neurogenic claudication from lumbar canal stenosis non-responsive to non-surgical treatment are usually managed with spinal decompression with or without fusion. Flexion at stenotic segments relieves symptoms by increasing canal cross-sectional area, intervertebral foraminal height. Interspinous spacers work by causing flexion at the treated segement. We used COFLEX¯ [Paradigm Spine] a titanium interspinous spacer along with interlaminar decompression where indicated.

To compare the clinical and radiological results of patients undergoing interlaminar decompression with or without use of COFLEX¯.

Pre and post-operative assessment and comparison of clinical outcomes of Oswestry disability index(ODI), Visual analog Scale(VAS), Short Form-36(SF-36) and radiological outcomes of disc heights of operated and adjacent levels, intervertebral foraminal heights, sagittal angles of the operated segment.

All consecutive patients undergoing spinal decompression at one or more levels from Jan to Dec 2008 were included. Patients with clinically symptomatic back pain for a duration longer than claudication pain were offered interspinous spacer at L4/5 level or above.

In first group(n-20), patients were treated with inter-laminar decompression and COFLEX¯ with a standard posterior approach. In second group(n-25) inter-laminar decompression for the involved segment was performed. All patients are on follow-up.

Clinical and radiological outcomes were compared at 6 months and 1 year.

Statistically significant(p<0.001) improvements in ODI, VAS(back), VAS(leg) and SF-36 in patients in whom COFLEX¯ was used. Radiological parameters also showed significant improvements(p<0.05).

Use of COFLEX¯ spacer is justified in patients with symptomatic disc degeneration with neurogenic claudication when treated operatively.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_X | Pages 89 - 89
1 Apr 2012
Nath C Chen Y Wilder-Smith E Kumar N
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Magnetic Resonance Imaging (MRI) is the cornerstone investigation for cervical disc disease (CDD). However, MRI changes suggestive of CDD are found in people above forty, even in asymptomatic healthy individuals [1].

Mere presence of MRI changes of CDD does not exclude the presence of concomitant extra-foraminal pathology.

No study design.

We present here a series of three cases where use of ‘high resolution ultrasound’ has allowed accurate diagnosis of concomitant extra-foraminal pathology in patients with MRI-proven CDD. The three cases were acute neuropraxia of aberrant C5 nerve root, anterior interossous nerve compression due to pseudo-aneurysm of brachial artery and ‘acute brachial neuritis’ respectively.

No outcome measure.

Use of diagnostic high resolution ultrasound revealed accurate diagnosis of concomitant extra-foraminal pathology in all three cases. The cases with acute neuropraxia and acute brachial neuritis recovered with conservative treatment. Pseudo-aneurysm was treated successfully with surgery.

High resolution ultrasound of the brachial plexus and peripheral nerves may be useful in following scenarios to identify an extra-foraminal pathology: (1) when symptoms and signs are out of proportion to the MRI findings of CDD; (2) when there is obvious discordance between MRI and nerve conduction findings; (3) where an entrapment neuropathy is suspected but the site of nerve lesion cannot be located.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 489 - 489
1 Sep 2009
Gowda V Singh G Kumar A Kumar N
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Background: Back pain in adult patients with a pars-interarticularis defect may be due to movement at the defect or abnormal inter-segmental movement at the adjacent degenerate disc. The suggested treatment of segmental fusion may not be necessary, if the defect alone was source of pain. We hypothesize that the defect may be the only source of pain in certain adults, even if the MRI scan shows an abnormal disc.

Objective: To form a protocol of management in adults with pars defect and adjacent level disc degeneration. To study the results of primary lysis repair using ‘AO Morscher clamp’ in patients with ‘spondylolysis’ or ‘Grade 1 ‘spondylolisthesis’.

Methods: This is a prospective study involving adults with ‘spondylolysis’ or ‘Grade 1 ‘spondylolisthesis’ not responding to conservative management and requiring interventional treatment. We investigated this subgroup of patients with lysis block and discography. On this basis, of a total of ten patients, seven were offered lysis repair and bone grafting using ‘Morscher’s clamp’; three were offered spinal fusion. Outcome was assessed using Visual Analogue Score (VAS) and Oswestry Disability Index (ODI) done pre-operatively and six months post-op.

Results: Out of ten patients (28 to 45 years; 4males and 6 females), seven patients underwent primary lysis repair using ‘AO Morscher clamp’. Union of pars achieved in all the patients by 4 months (Follow-up 4 months to 2 years). Three underwent fusion. Mean VAS improved from 7.2 to 1.2 in lysis repair group. Mean ODI improved from 68 % to 24%. All patients had full range of spinal movement postop.

Conclusion: A thorough pre-operative workup of patients with pars defect and adjacent level disc degeneration showed that pain is due to the pars defect in 70% of our cohort. This subgroup of patients could successfully be treated with ‘lysis repair’ rather than a more morbid procedure of ‘spinal fusion’.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 486 - 486
1 Sep 2009
Kumar N Guo-Xin N Wong H
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Study Design: A radiographic study using disarticulated cadaver thoracic vertebrae.

Objective: To determine the accuracy of orthogonal X-rays in detecting thoracic pedicle screw position by different groups of observers.

Summary of Background Data: Pedicle screws are increasingly being used for internal fixation of the thoracic spine. Surgeons and radiologists are often required to make decisions on the pedicle screw position by plain antero-posterior (AP) and lateral radiographs.

Materials and Methods: 23 disarticulated fresh adult thoracic vertebrae were used in this study. Pedicle screws were inserted completely within the pedicle; or deliberately violating the lateral or medial cortex of the pedicle. AP and lateral radiographs of each vertebrae were assessed by 2 spine surgeons, 2 spine trainees, and 2 musculoskeletal radiologists in a sequence of AP alone, and AP + lateral views. They were supposed to cataogorize the pedicular screw as ‘out laterally’/‘inside the pedicle’/‘out medially’ or ‘unsure’. Their assessments were compared to the actual position of the screws determined by the axial views.

Results: For each screw position, trend was found towards slightly better accuracy with availability of AP & lateral views in combination. From either AP alone or AP + lateral views, significantly higher accuracy was found in detecting screws “out laterally” than “inside pedicle” (p< 0.01), or “out medially”(p< 0.05), respectively. Nearly 30% of screws that were deliberately placed through the medial pedicle wall were not correctly identified. In addition, surgeons have highest accuracy from either AP alone, or AP + lateral views, followed by the spine trainees and radiologists. Radiologists provided more “unsure” answers than surgeons or trainees.

Conclusions: Screws that perforated the lateral cortex were the easiest, and those that were wholly within the pedicle were the most difficult to identify correctly. The use of plain radiographs to detect thoracic pedicle screws placed through the critical medial cortex is unreliable. The positions of thoracic pedicle screws appear to be more accurately detected by AP + lateral, however, the major contribution was from AP views. Surgeon experience continues to be vitally important in the safe placement of thoracic pedicle screws.

Key points:

Screws that perforated the lateral cortex were the easiest, and those that were wholly within the pedicle were the most difficult to identify correctly.

The use of plain radiographs to detect thoracic pedicle screws placed through the critical medial cortex is unreliable.

AP + lateral views provides higher accuracy in determining the screw position, while, the major contribution comes from AP views.

Surgeon experience, in the use of tactile skills and anatomical knowledge continue to be vitally important in the safe placement of thoracic pedicle screws.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 449 - 449
1 Aug 2008
Gowda VP Kumar A Kakarala G Fraser AM Kumar N
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We describe results of a new ‘two needle technique’ of selective nerve root blocks done through posterior triangle of neck in the management of cervical radiculopathy with 2 year results.

Methods: Patients presenting with cervical radiculopathy were evaluated clinically and radiologically and were initially managed with supervised physiotherapy, analgesics and rest. Selective cervical nerve root block was offered to the patients, who did not respond to conservative management. The procedure was performed as a day case, under local anesthesia, with image intensifier guidance, using ‘two needle technique’. A thinner needle is rail-roaded through the lumen of large diameter guide needle to reach the target nerve root foramen and a mixture of Bupivacaine and Triamcinolone acetonide is injected. The outcome was measured using visual analogue score (VAS) and neck disability index (NDI) done on the day of the procedure and compared to the scores at 3 months and 1 year after the procedure.

Results: Outcome in 30 patients who underwent this procedure over three years’ period is presented. Average Visual Analogue Score was 7.36 (range 6 – 10) before the intervention, which improved to 2.27 (range 0 – 7) at 3 months and 1.9 (range 0 – 4) at 1 year. The average Neck Disability Index score prior to intervention was 66.87 (range 44 to 82), which improved to 31.67 (range 18 – 66) at 3 months and 30.44 (range 20 – 48) at 1 year. There were no major complications noted. We conclude that selective cervical nerve root block using ‘two-needle technique’ is safe and reproducible. The therapeutic effect achieved is long lasting, making this procedure a good alternative to surgical management in patients with cervical radiculopathy who do not respond to conservative management.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 165 - 165
1 Mar 2006
Michael A Kansal A Kumar N Binfield P
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Background Ankle fractures vary in the amount of displacement, damage to the articular surface and disruption of the ligamentous structures. The consequences of injury will vary according to the fracture pattern and the patient. When a patient sustains an injury we would like to know both the early and late result of treatment for that particular patient. There has been debate about the instrument to be used for this follow up.

The aim of the present study is firstly to determine the outcome after open reduction and internal fixation of ankle fractures using the AO/ASIF principles and secondly to determine if the modified version of the scoring system of Phillips et al was appropriate for early and late follow up.

Method Retrospective analysis of case notes and radiographs of patients requiring ORIF of an Ankle fracture between 01/01/98 to 30/03/00. The end date was chosen so that all patients had a minimum of one year followup.

Patients with incomplete follow up, notes and radiographs were excluded. Functional outcome was assessed using a modified version of the scoring system of Phillips et. al. This was sent to patients by post.

Results 106 patients were included in the study. 50 male and 56 female. Age ranged from 14 to 83 mean 47. There were 6 type A, 43 typeB and 59 type C fractures according to the Danis Weber system.

2 were open fractures. There were 5 patients with significant associated injuries. 29 patients had significant co-morbid conditions.

29 patients had surgery on the date of admission. The mean interval to surgery was 3 days.

Patients were followed up regularly in the Out patients clinic

Reduction of fracture was assessed on post operative radiographs using the criteria of Joy et al (1974).

66 patients returned the questionnaire and the functional outcome was determined for this group. 51 patients had an excellent result, 6 patients had a good result, 5 patients had a satisfactory result 4 patients had a poor result. Detailed outcome and complications will be presented in our paper.

Conclusions Fixation of Ankle fractures according to the AO/ASIF guidelines gives good results in the short term with acceptable rate of complications.

Subjective assessment is satisfactory for measuring early and late outcome after Ankle surgery.

No statistically significant factors affected outcome in our study.


The Journal of Bone & Joint Surgery British Volume
Vol. 71-B, Issue 4 | Pages 703 - 703
1 Aug 1989
Phen H Kumar N Ireland J