DXA areal-bone-mineral-density (aBMD) is used clinically as a surrogate for true volumetric-BMD to assess bone fragility. Trabecular-Bone-Score (TBS) provides an assessment of bone quality based on the DXA-derived two-dimensional images. Calculated from bone area (BA), aBMD may under- or overestimate true BMD in individuals with relatively low and high BA respectively. This study investigated relationships between BA at the lumbar-spine (L1–L4) and measurements of BMD and TBS. Lumbar spine scans were performed (GE Lunar Prodigy) on 114 women (mean 53 yrs). The study population was divided by L1–L4 BA using the 20th and 80th centiles, and BMD v TBS correlations calculated for the subgroups. BMD and TBS, converted to Z-scores, were correlated with BA.Introduction
Method
Precision error (PE) in Dual Energy X-Ray Absorptiometry (DXA) is important for accurate monitoring of changes in Bone-Mineral-Density (BMD). It has been demonstrated that BMD PE increases with increasing BMI. In vivo PE for the Trabecular-Bone-Score (TBS) has not been reported. This study aimed to evaluate the short-term PE (STPE)) of BMD and TBS and to investigate the effect of obesity on DXA PE. DXA lumbar spine scans (L1–L4) were performed using GE Lunar Prodigy. STPE was measured in 91 women (Group A) at a single visit by duplicating scans with repositioning in-between. PE was calculated as the percentage coefficient of variation (%CV). Group A was sub-divided into four groups based on BMI (A.1. <25kg/m2, A.2. 25–29.9kg/m2, A.3. 30–35kg/m2 and A.4. >35kg/m2) to assess the effect of obesity on STPE. Abnormally different vertebrae were excluded from the analysis in accordance with The International Society for Clinical Densitometry (ISCD) recommendations.Introduction
Method
The shape of the vertebral bodies from L1 to L4 was assessed from lateral dual-energy x-ray absorptiometry (DXA) images using an active shape model. The output from the model was compared to measurements of areal bone mineral density in L1 to L4 (aBMD) using a stepwise linear regression model. A significant relationship was found between aBMD and vertebral shape that suggests that the method may be useful for correcting artefacts such as osteophytes.
Weight-bearing is a known stimulus for bone remodelling and a reduction in weight-bearing is associated with reduced bone mineral density (BMD) in affected limbs post lower limb fracture. This study investigated short and long-term precision of a method for measuring relative left/right weight-bearing using two sets of identical calibrated scales. The effect of imbalance on BMD at the hip and on lower limb lean tissue mass (LLTM) was also assessed. 46 postmenopausal women, with no history of leg or ankle fracture, were measured three times whilst standing astride two scales (Seca, Germany). 34 of the participants were re-measured after 6 months by the same method. Bilateral hip and total body dual x-ray absorptiometry measurements were performed using a GE Lunar Prodigy (Bedford, MA). Precision errors in weight-bearing measures were calculated using the root mean square coefficient of variation (RMSCV%). The correlations at the first visit between left/right differences in weight-bearing and differences in BMD and LLTM were calculated. The short-term RMSCV% for left and right weights were 4.20% and 4.25% respectively and the long-term RMSCV% were 6.91% and 6.90%. Differences in left/right weight-bearing ranged from 0 to 24% (SD 8.63%) at visit 1 and 0 to 30% (SD 10.71%) at visit 2. Using data from visit 1, the relationship between hip BMD differences and left/right weight-bearing differences were investigated, with no significant correlations found. However, a weak, but statistically significant correlation of r=0.35 (p=0.02) was found for differences in LLTM and left/right weight-bearing differences. In conclusion, left/right weight-bearing measured using two scales is a precise method for evaluating differences in weight-bearing in the short and long-term. Differences in left/right weight-bearing in this population varied by up to 30%. Participants showed a high degree of consistency in their long-term balance in a natural standing posture. Inequalities in left/right weight-bearing did not correlate significantly with BMD at the hip, but demonstrated a weak but statistically significant correlation with lean tissue mass.
