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The Bone & Joint Journal
Vol. 102-B, Issue 2 | Pages 162 - 169
1 Feb 2020
Hoellwarth JS Tetsworth K Kendrew J Kang NV van Waes O Al-Maawi Q Roberts C Al Muderis M

Aims

Osseointegrated prosthetic limbs allow better mobility than socket-mounted prosthetics for lower limb amputees. Fractures, however, can occur in the residual limb, but they have rarely been reported. Approximately 2% to 3% of amputees with socket-mounted prostheses may fracture within five years. This is the first study which directly addresses the risks and management of periprosthetic osseointegration fractures in amputees.

Methods

A retrospective review identified 518 osseointegration procedures which were undertaken in 458 patients between 2010 and 2018 for whom complete medical records were available. Potential risk factors including time since amputation, age at osseointegration, bone density, weight, uni/bilateral implantation and sex were evaluated with multiple logistic regression. The mechanism of injury, technique and implant that was used for fixation of the fracture, pre-osseointegration and post fracture mobility (assessed using the K-level) and the time that the prosthesis was worn for in hours/day were also assessed.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_7 | Pages 18 - 18
1 May 2018
Phillip R Muderis MA Kay A Kendrew J
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Advances in military surgery have led to significant numbers of soldiers surviving with bilateral above knee amputations. Despite advances in prosthetic design and high quality rehabilitation not all amputees succesfully ambulate. Five patients (10 stumps) with persisting socket fit issues were selected for osseointegration (OI) using a transcutaneous prosthesis with press-fit fixation in the residual femur. Prior to surgery all five were primarily/exclusively wheelchair users.

Follow up was from 7 to 25 months (mean 12.2). There were no deaths, episodes of sepsis or osteomyelitis. There was one proximal femoral fracture secondary to a fall. One stump required soft tissue refashioning. Cellulitis needing oral antibiotics occurred in four cases.

Functional improvement occurred in all cases with all currently primarily prosthetic users, the majority all day users. Three patients are still completing rehabilitation. Six minute walk tests (SMWT) improved by a mean of 20%. Three are now graded mobility SIGAM F (normal gait) and two SIGAM D-b (limited terrain; with one stick).

This cohort suggests that OI may have a role in the treatment of military blast amputees. A larger scale clinical evaluation is planned in the UK blast related amputee population to further establish the benefits and risks of this technique


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_26 | Pages 7 - 7
1 Jun 2013
Walker N McKinnon J Green A Kendrew J Clasper J
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Published infection rates following wounds sustained in combat vary dramatically. We reviewed UK military extremity trauma, sustained in Afghanistan over a two year period, to evaluate early infection rates and causative organisms. Data on wound site, time to onset of infection, organisms detected and method of presentation were collected.

351 patients had full datasets for clinical wound surveillance and microbiological data. 58 (16.5%) patients were diagnosed with wound infections. Median time to diagnosis was 17 days (range = 749, Interquartile range =31.75 days). Limb infection was detected in 53 (15.1%) patients. Infection was statistically significantly more likely to be incurred in the lower extremity (p=0.0220). Multiple organisms were identified in 34 (64.2%) of the 53 patients with a limb infection. Fungi were significantly more common in early presenters (<30 days after injury) (p=0.0024). Staphylococcus aureus was significantly more likely in late presentation (p=0.002). Infection was more likely in those injured by an improvised explosive device (p=0.0019).

The overall infection rates recorded are low when compared to historical data. Organisms isolated from infected wounds are frequently multiple. The microbial spectrum and the number of organisms present on diagnosis change with time from wounding.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_7 | Pages 15 - 15
1 Feb 2013
Evans S Ramasamy A Kendrew J Cooper J
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Aim/Purpose

Review our unique experience in the management of 29 consecutive casualties who survived open pelvic fractures following a blast mechanism.

Methods and Results

Retrospective study utilising a prospectively collected combat trauma registry. Records of UK Service Personnel sustaining open pelvic fractures from an explosion from Aug 2008 – Aug 2010 identified. Casualties who survived to be repatriated to the Royal Centre for Defence Medicine, University Hospital Birmingham were selected for further study. The median New Injury Severity Score (NISS) was 41. Mean blood requirement in the first 24 hours was 60.3 units. In addition to their orthopaedic injury, 6 (21%) had an associated vascular injury, 7(24%) had a bowel injury, 11 (38%) had a genital injury and 7(24%) had a bladder injury. 8 (28%) fractures were managed definitively with external fixation, and 7 (24%) fractures required internal fixation. Of those patients who underwent internal fixation, 5 (57%) required removal of metalwork for infection. Faecal diversion was performed on 9 (31%) casualties. Median length of stay was 70.5 days, and mean total operative time was 29.6 hours. At a mean 20.3 months follow-up, 24 (83%) were able to ambulate, and 26 (90%) had clinical and radiological evidence of pelvic ring stability.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_8 | Pages 14 - 14
1 Feb 2013
Bonner T Singleton J Masouros S Gibb I Kendrew J Clasper J
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Counter-insurgency warfare in recent military operations has been epitomised by the use of Improvised Explosive Devices (IED) against coalition troops. Emerging patterns of skeletal fractures, limb amputations and organ injuries, which are caused by these weapons have been described over recent years. This paper describes a retrospective case series of knee dislocations caused by IEDs in recent conflict.

Data was obtained about military personnel from 2006 to 2011, who had sustained a knee dislocation while serving in Afghanistan from a prospectively gathered database, the Joint Theatre Trauma Registry (JTTR), maintained by the Academic Department of Military Emergency Medicine, Royal Centre for Defence Medicine. The diagnosis of knee dislocation and its associated skeletal injuries was assessed by review of all relevant plain radiographs, computed tomography scans and magnetic resonance images. The mechanism of injury, incidence of vascular injuries and other skeletal injuries was recorded.

During the study period, 23 casualties sustained a knee dislocation caused by an IED. Four casualties had an associated popliteal vascular injury. Eleven injuries were caused in enclosed spaces, and 10 injuries caused by IEDs out in the open. Anterior dislocations were common in the group caused in enclosed spaces. 19/20 patients had at least one other skeletal fracture.

Knee dislocations represent an uncommon but important diagnosis in modern warfare. Urgent and careful assessment for any associated vascular injuries or other skeletal injuries may help ensure timely treatment and promote future recovery. Mitigation against knee dislocation may be possible in the enclosed environment because of the predictable pattern of injury.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 121 - 121
1 Jan 2013
Evans S Ramasamy A Cooper J Kendrew J
Full Access

The aim of this study is to review our unique experience in the management of 29 consecutive casualties who survived open pelvic fractures following a blast mechanism, in order to determine the injury pattern, clinical management and outcome of these devastating injuries.

All patients were serving soldiers who were injured whilst on operations in Afghanistan. The median New Injury Severity Score (NISS) was 41. Mean blood requirement in the 1st 24 hours was 60.3 units. In addition to their orthopaedic injury, 6 (21%) had an associated vascular injury, 7(24%) had a bowel injury, 11 (38%) had a genital injury and 7(24%) had a bladder injury. 8 (28%) fractures were managed definitively with external fixation, and 7 (24%) fractures required ORIF. Of those patients who underwent ORIF, 4 (57%) required removal of metalwork for infection. Faecal diversion was performed on 9 (31%) casualties. Median length of stay was 70.2 days, and mean total operative time was 29.6 hours. At a mean 20.3 months follow-up, 24 (83%) were able to ambulate, and 26 (90%) had clinical and radiological evidence of pelvic ring stability.

The “Global War on Terror” has resulted in incidents that were previously confined exclusively to conflict areas can now occur anywhere, and surgeons who are involved in trauma care may be required to manage similar injuries from terrorist attacks. Our study clearly demonstrates that the management of this injury pattern is extremely resource intensive with the need for significant multi-disciplinary input. Given the nature of the soft tissue injury, we would advocate an approach of minimal internal fixation in the management of these fractures. With the advent of emerging wound and faecal management techniques, we do not believe that faecal diversion is mandated in all cases.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 115 - 115
1 May 2011
Quah C Kendrew J Swamy G Badhe N
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Introduction: Stiffness following total knee arthroplasty is a disabling problem resulting in pain and reduced function. Prevalence is not well defined and although various treatment modalities including manipulation, arthrolysis and revision surgery has been proposed with varying degrees of success for reduced flexion, these Methods: are deemed to be of limited value in fixed flexion deformity (FFD). There is limited literature on the natural history of FFD which is important to the decision process. The aim of our study was to evaluate the natural course of FFD following primary total knee arthroplasty.

Methods: Prospective review of a consecutive series of 1768 patients who underwent primary total knee arthroplasty over a 7 year (2001 to 2008) period. Demographic data included post-operative range of motion; type of prosthesis used, treatment modalities for stiffness and the final range of motion were recorded. FFD was defined as class 1(hyperextension to 0), Class 2 (1–10 degrees), Class 3(11–20 degrees) and Class 4(> 20 degrees).

All patients were reviewed by an independent reviewer (senior physiotherapist). All patients were followed from 6 weeks post surgery until FFD completely resolved or improved to patient satisfaction. Patients with infection, stiffness treated with manipulation or revision surgery were excluded from the study. Patients lost to follow-up were noted.

Results: Of the 1768 patients evaluated, 180 (10.2%) presented with a FFD. A total number of 18 patients were excluded from the study and 16 were lost to follow up. None (0%) were class 1, 134 (91.8%) were class 2, 10 (6.9%) were class 3 and 2 (1.4%) were class 4. The FFD group had a mean age of 60.5. Follow up period ranged from 1.3 to 63.3 months and the FFD improved from a mean of 8.16 degrees to 0.15 degrees (p< 0.001). In 94.5% patients the FFD completely resolved (i.e. < 5 deg) at a mean of 9.76 months. In the remaining 5.5% of patients, FFD improved from a mean of 16.4 to 6.9 degrees at a mean follow up of 15.5 months and was found to cause no functional deficit.

Conclusion: The overall prevalence of fixed flexion deformity is 10.2 % with only 0.7% in Class 3 and Class 4, which is comparable with the literature. The majority of patients will see a resolution of their fixed flexion deformity in less than 10 months with routine post operative physiotherapy. The small number of patients left with a residual FFD did not appear to suffer a functional deficit. Patients found to have a post operative FFD should be reassured and encouraged to participate in a standardised post operative physiotherapy regime.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 209 - 210
1 May 2009
Kiely P Lam K Kendrew J Scheuler A Breakwell L Kerslake R Webb J
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High velocity vertical aircraft ejection seat systems are credited with aircrew survival of 80–95% in modern times. Use of these systems is associated with exposure of the aircrew to vertical acceleeration forces in the order of 15–25G. The rate of application of these forces maybe upto 250G per sceond. Upto 85% of crew ejecting suffer skeletal injury and vertebral fracture is relatively common (20–30%) when diagnosed by plain radiograph. The incidence of subtle spinal injury may not be as apparent.

A prospective case series, admitted to QMC Nottingham, from 1996 to 2006 was evaluated. During this interval 26 ejectees from 20 aircraft were admitted to the spinal studies unit for comprehensive examination, evaluation and management. The investigations included radiographs of the whole spine and magnetic resonance Imaging (incorporating T1, T2 weighted and STIR saggital sequences). All ejections occurred within the ejection envelope and occurred at an altitude under 2000 feet (mean 460 feet) and at an airspeed less than 500 knots (mean 275 knots).

In this series 6 ejectees (24%) had clinical and radiographic evidence of vetebral compression fractures. These injuries were located in the thoracic and thoracolumbar spine. 4 cases required surgery ( indicated for angular kyphosis greater than 30 degrees, significant spinal canal compromise, greater than 50% or neurological injury. 1 patient had significant neurological compromise, following an AO A3.3 injury involving the L2 vertebra.

11 ejectees (45 %) had MRI evidence of a combined total of 22 occult thoracic and lumbar fractures. The majority of these ejectees with occult injury had multilevel injuries.

This study confirms a high incidence if spinal fracture and particularly occult spinal injury. Evidently vertical emergency aircraft ejection imposes major insults on the spinal column. Once, appropriately prioritised, life preservation measures have been undertaken, an early MRI of the spne is mandatory as part of comprehensive patient evaluation.

Correspondence should be addressed to Major M Butler RAMC, Princess Elizabeth Orthopaedic Centre, Royal Devon and Exeter Hospital, Exeter, Devon.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 9 - 9
1 Mar 2008
Kendrew J Varley J Parker M
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One of the most common early complications after hemiarthroplasty is dislocation, with an incidence of 2 to 4%. After dislocation the mortality and morbidity are significantly increased to in excess of 50%.

It has been claimed that a bipolar hemiarthroplasty has a lower risk of dislocation than a unipolar implant. In addition it has been suggested that patients with either Parkinson’s disease or a previous stroke are at increased risk of dislocation. We investigated these claims by performing a comprehensive literature search of articles published in the last 40 years and data obtained from our own hip fracture database.

From the literature review, 133 reports involving 21,872 patients were retrieved. A further 1235 hip fractures treated by hemiarthroplasty were recorded from our database. 791 (3.4%) dislocations were recorded. Dislocation rate for unipolar prosthesis was higher than bipolar prosthesis (3.9% versus 2.5%). Dislocation rate for posterior surgical approach was higher than for anterior approach (5.1% versus 2.4%). Dislocation rate for cemented prosthesis was 3.6% versus 2.3% in un-cemented prosthesis. However, the effect of the type of implant becomes non-significant on adjusting for the use of cement and surgical approach. The incidence of open reduction after dislocation was increased with bipolar implants. Patients with Parkinson’s disease showed a highly statistically significant increase in dislocation rate (8.7% to 3.4%). The dislocation rate with respect to ipsilateral hemiplegia was 1.6%.

This study indicates there is no difference in the dislocation rate between a unipolar and bipolar prosthesis but if a bipolar prosthesis dislocates, there is an increased risk of failure to reduce the prosthesis by closed means. Patients with Parkinson’s disease are at an increased risk of dislocation but this is not the case for those with a hemiplegia. To minimise the risk of dislocation of a hemiarthroplasty, particularly in those patients with Parkinson’s disease, a unipolar hemiarthroplasty inserted via an antero-lateral approach is recommended.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 264 - 264
1 May 2006
Kendrew J Gurusuamy K Parker MJ
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The admission radiographs for 404 patients with a displaced intracapsular hip fracture treated by reduction and internal fixation were classified using five different variables. These were the Garden grade, a modified Garden grading, a ratio of fracture displacement, direct measurement of fracture shortening and trochanteric shortening. Inter-observer reliability of the various classifications was also studied.

Only trochanteric shortening had an acceptable degree of inter-observer variation. For the Garden grading equal numbers of grade III and IV fracture healed. For the modified Garden grading 36% of Grade III fractures developed non-union against 48% of grade IV fractures (p value =0.02). The ratio method and fracture shortening were related to fracture healing complications, but trochanteric shortening was predictive of fracture healing (15.2 mms versus 11.0 mm), although the usefulness of this measure in clinical practice has to be questioned.