Osteoarthritic (OA) changes to the bone morphology of the proximal tibia may exhibit load transfer patterns during total knee arthroplasty not predicted in models based on normal tibias. Prior work highlighted increased bone density in transverse sections of OA knees in the proximal-most 10mm tibial cancellous bone. Little is known about coronal plane differences, which could help inform load transfer from the tibial plateau to the tibial metaphysis. Therefore, we compared the cancellous bone density in OA and cadaveric (non-OA) subjects along a common coronal plane.

This study included nine OA patients (five women, average age 59.1 ± 9.4 years) and 18 cadaver subjects (four women, average age 39.5 ± 14.4 years). Patients (eight with medial OA and one with lateral OA) received pre-operative CT scans as standard-of-care for a unicompartmental knee replacement. Cadavers were scanned at our institution and had no history of OA which was confirmed by gross inspection during dissection.

3D reconstructions of each proximal tibia were made and an ellipse was drawn on the medial and lateral plateau using a previously published method. A coronal section (Figure 1) to standardize the cohort was created using the medial ellipse center, lateral ellipse center, and the tibial shaft center 71.5mm from the tibial spine. On this section, profile lines were drawn from the medial and lateral ellipse centers, with data collected from the first subchondral bone pixel to a length of 20mm. The Hounsfield Units (HU) along each profile line was recorded for each tibia; a representative graphical distribution is shown in Figure 2. The Area Under the Curve (AUC) was calculated for the medial and lateral sides, which loosely described the stiffness profile through the region of interest. To determine differences between the medial and lateral subchondral bone density, the ratio AUC[medial] / AUC[lateral] was compared between the OA and cadaver cohorts using a two-sample t-test. Data from the sole lateral OA patient was mirror-imaged to be included in the OA cohort.

The majority of the OA patients appeared to have higher subchondral bone density on the affected side. Figure 3 compares the medial and laterals sides of each group using the AUC ratio method described above. For the cadaver group the AUC was 1.2 +/− 0.22, with a median of 1.1 [0.9 1.6], smaller than the mean AUC for the OA group, which was 1.4 +/− 0.39, with a median of 1.6 [0.93 2.1]. The p-value was 0.06.

The increased density observed in OA patients is consistent with asymmetric loading towards the affected plateau, resulting in localized remodeling of cancellous bone from the epiphysis to metaphysis. From the coronal plane, bone was often observed in OA patients bridging the medial plateau to the metaphyseal cortex. Although the cadaver subjects were normal from history and gross inspection, some subjects exhibited early bone density changes consistent with OA. Future work looks to review more OA scans, extend the work to the distal femur, and convert the HU values to bone elastic moduli for use in finite element modelling.

This randomized clinical trial compares fixed- and mobile-bearing total knee prostheses in terms of the patients’ clinical outcome parameters (Knee Society Clinical Rating, WOMAC, SF-12), range of motion and performance during gait analysis for level-ground walking. Our results show no significant differences in the clinical outcomes and gait performance of the fixed- and mobile-bearing total knee arthroplasties.

The purpose of this study was to compare the clinical outcomes and gait parameters of patients with a fixed-bearing or mobile-bearing total knee arthroplasty (TKA).

Fifty-five patients were entered into a prospective, randomized clinical trial comparing fixed- versus mobile-bearing TKAs (Genesis II, Smith & Nephew, Memphis, TN). From this patient population, fifteen fixed-bearing and fifteen mobile-bearing TKA patients were matched based on age, sex and BMI to undergo gait analysis. Patients performed trials of level-ground walking at a self-selected velocity while three-dimensional kinetic and kinematic data were collected.

The fixed-bearing and mobile-bearing TKA patient groups were comparable regarding Knee Society Clinical Rating (181 ± 22 versus 171 ± 28), WOMAC scores (7 ± 5 versus 9 ± 12), SF-12 and range of motion (121° ± 11° versus 125° ± 6°).

Patients with fixed- and mobile-bearing TKAs performed similarly in the gait analysis in terms of their velocity, percent weight acceptance in the operated versus the non-operated limb, peak flexion in stance and swing phases, the support moments and extension moments at the ankle, knee and hip. Decreased peak extension in the mid-stance and swing phases was observed in the operative limb versus the non-operative limb for both fixed- and mobile-bearing TKAs (P=0.02 and 0.04). Decreased peak extension was also observed during mid-stance and swing phases in the mobile-bearing TKAs versus the fixed-bearing TKAs (P=0.064 and 0.052).

Fixed-bearing and mobile-bearing TKAs perform similarly in terms of their clinical outcome measures and the kinetics and kinematics of level-ground walking.

Funding for this project obtained from Smith & Nephew, Memphis, TN.

The peak external knee adduction moment during walking gait has been proposed to be a clinically useful measure of dynamic knee joint load in patients with knee osteoarthritis. However, there is limited information about the reliability of this measure, or its ability to detect change. The test-retest reliability and sensitivity to change of peak knee adduction moments were evaluated in thirty patients with varus gonarthrosis. Indices of relative and absolute reliability were excellent (intra-class correlation coefficient = 0.85, standard error of measurement = 0.36 % BW*Ht), and the sensitivity to change following high tibial osteotomy was high (standardized response mean = 1.2).

To estimate the test-retest reliability, measurement error and sensitivity to change of the peak knee adduction moment during gait.

Thirty patients (44”11 yrs, 1.7”0.09 m, 87”20 kg, twenty males, ten females) with varus gonarthrosis underwent gait analyses on two pre-operative test occasions within one week, and on a third test occasion six months after medial opening wedge high tibial osteotomy. Three-dimensional kinematic and kinetic gait data were collected during self-paced walking and used to calculate the peak knee adduction moment.

An intraclass correlation coefficient of 0.85 (95%CI: 0.71, 0.93) indicated excellent relative reliability, and a standard error of measurement of 0.36 %BW*Ht (95%CI: 0.29, 0.49) indicated low measurement error. The peak knee adduction moment after surgery (1.66”0.72 %BW*Ht) was significantly (p< 0.001) lower than before surgery (2.58”0.72 %BW*Ht). A standardized response mean of 1.2 (95%CI: 0.77, 1.6) indicated the size of this change was large.

Based on 95% confidence levels, these results suggest the error in an individual’s peak knee adduction moment at one point in time is 0.70 % BW*Ht, the minimal detectable change in an individual’s peak adduction moment is 1.0 %BW*Ht, and it is sensitive to change following treatment.

The peak knee adduction moment during gait has appropriate reliability for use in studies evaluating the effect of treatments intended to decrease the load on the knee. When considering measurement error, the knee adduction moment is also appropriate for clinical use in evaluating change in individual patients.

Funding: CIHR, Arthrex Inc.