Aims

Accurate estimations of the risk of fracture due to metastatic bone disease in the femur is essential in order to avoid both under-treatment and over-treatment of patients with an impending pathological fracture. The purpose of the current retrospective in vivo study was to use CT-based finite element analyses (CTFEA) to identify a clear quantitative differentiating factor between patients who are at imminent risk of fracturing their femur and those who are not, and to identify the exact location of maximal weakness where the fracture is most likely to occur.

Aims

Intra-articular ⁹⁰Yttrium (⁹⁰Y) is an adjunct to surgical treatment by synovectomy for patients with diffuse-type tenosynovial giant-cell tumour (dtTGCT) of the knee, with variable success rates. Clinical information is, however, sparse and its value remains unclear. We investigated the long-term outcome of patients who underwent synovectomy with and without adjuvant treatment with ⁹⁰Yttrium.

Background

Dislocation is a common complication after proximal and total femur prosthesis reconstruction for primary bone sarcoma patients. Expandable prosthesis in children puts an additional challenge due to the lengthening process. Hip stability is impaired due to multiple factors: Resection of the hip stabilizers as part of the sarcoma resection: forces acts on the hip during the lengthening; and mismatch of native growing acetabulum to the metal femoral head. Surgical solutions described in literature are various with reported low rates of success.

Excision of the proximal femur for tumour with prosthetic reconstruction using a bipolar femoral head places a considerable load on the unreplaced acetabulum.

We retrospectively reviewed the changes which occur around the affected hip joint by evaluating the post-operative radiographs of 65 consecutive patients who underwent proximal prosthetic arthroplasty of the femur, and in whom an acetabular component had not been used. There were 37 men and 28 women with a mean age of 57.3 years (17 to 93). Radiological assessment included the extent of degenerative change in the acetabulum, heterotopic ossification, and protrusio acetabuli.

The mean follow-up was 9.1 years (2 to 11.8). Degenerative changes in the acetabulum were seen in three patients (4.6%), Brooker grade 1 or 2 heterotopic ossification in 17 (26%) and protrusion of the prosthetic head in nine (13.8%).

A total of eight patients (12.3%) needed a revision. Five were revised to the same type of prosthesis and three (4.6%) were converted to a total hip arthroplasty.

We conclude that radiological evidence of degenerative change, heterotopic ossification and protrusion occur in a few patients who undergo prosthetic arthroplasty of the proximal femur for tumour. The limited extent of these changes and the lack of associated symptoms do not justify the routine arthroplasty of the acetabulum in these patients.

Cite this article: Bone Joint J 2015;97-B:1704–9

Aim

Giant cell tumour (GCT) of bone is a benign but locally aggressive tumour. Although topical adjuvants have been used in the past, local recurrence following intralesional excision of GCT of bone continues to remain a problem. The use of bisphosphonates as an anti-osteoclastic agent in the management of osteolytic bone metastases is well accepted. Therefore our study aims to retrospectively demonstrate whether the administration of bisphosphonate as an adjuvant can control aggressive local recurrence of GCT and prevent wide resections of bones or amputations.

Background

Cryosurgery is a well established modality in the treatment of benign aggressive and low grade malignant tumours. In this setting it allows for intra-lesional resection and preservation of function without compromising oncological outcome. Here we present the outcome of 87 patients treated with cryosurgery for low-grade chondrosarcoma of bone.

Various chemicals are commonly used as adjuvant treatment to surgery for giant-cell tumour (GCT) of bone. The comparative effect of these solutions on the cells of GCT is not known. In this study we evaluated the cytotoxic effect of sterile water, 95% ethanol, 5% phenol, 3% hydrogen peroxide (H₂O₂) and 50% zinc chloride (ZnCI₂) on GCT monolayer tumour cultures which were established from six patients. The DNA content, the metabolic activity and the viability of the cultured samples of tumour cells were assessed at various times up to 120 hours after their exposure to these solutions.

Equal cytotoxicity to the GCT monolayer culture was observed for 95% ethanol, 5% phenol, 3% H₂O₂ and 50% ZnCI₂. The treated samples showed significant reductions in DNA content and metabolic activity 24 hours after treatment and this was sustained for up to 120 hours. The samples treated with sterile water showed an initial decline in DNA content and viability 24 hours after treatment, but the surviving cells were viable and had proliferated. No multinucleated cell formation was seen in these cultures.

These results suggest that the use of chemical adjuvants other than water could help improve local control in the treatment of GCT of bone.

Objectives: A stable shoulder is essential for proper elbow and hand function after oncologic resection of the shoulder girdle. We describe a surgical technique for replacing the shoulder joint capsule using synthetic mesh after resections of the shoulder girdle that resulted in gross intraoperative instability of the shoulder joint.

Methods: 68 patients who underwent shoulder girdle resection between 1989 and 2006 were identified in our prospective database. This report focuses on nine patients whose shoulder joint was reconstructed with synthetic mesh. All patients were followed on a 3 monthly basis. Shoulder joint instability was determined from clinical records, database and radiographs.

Results: Nine patients underwent shoulder joint reconstruction with synthetic mesh. One patient underwent a shoulder disarticulation within 30 days of the index surgery and was excluded from this rapport.

No dislocations were noted during follow-up (range 3–48 months). Radiographs revealed an average vertical displacement of the humeral head compared to its original position of 0.7 cm (range 0–1.7 cm). There were two surgical complications. In one patient the humeral prosthesis migrated proximally and eroded through the skin requiring additional surgery. In another case erosion of the distal clavicle was noted. This was biopsied and foreign body reaction identified.

Conclusions: Joint instability following major resections of the shoulder girdle is a source of morbidity and affects the function of the salvaged limb. Synthetic capsular reconstruction using Marlex mesh is a useful adjunct in patients where insufficient shoulder musculature and joint capsule remains after resection to allow for stable suspension of the upper limb.

Objectives: To formulate a scoring system enabling decision making for prophylactic stabilization of the femur following surgical resection of a soft tissue sarcoma (STS) of the thigh.

Methods: A logistic regression model was developed using patient variables collected from a prospective database. The test group included 22 patients with radiation-related pathological femur fracture following surgery and radiation for a thigh STS. The control group of 79 patients had similar treatment but without a fracture. No patients received chemotherapy. Mean follow-up was 8.6 years. Variables examined were: Age (< 49, 50–70, > 70 years), gender, tumor size (0–7, 8–14, > 14 cm), radiation dose (low=5000 cGy, high> 6000 cGy), extent of periosteal stripping (< 10, 10–20, > 20 cm) and thigh compartment (posterior, adductor, anterior). A score was assigned to each variable category based on the coefficients obtained in the logistic regression model.

Results: Based on the regression model and an optimal cut-point, the ability to predict radiation associated fracture risk was 91% sensitive and 86% specific. The area under the Receiver Operating Characteristic (ROC) curve was 0.9, which supports this model as a very accurate predictor.

Conclusions: Radiation-related femur fractures following combined surgery and radiation treatment for STS are uncommon, but are difficult to manage and their non-union rate is extremely high. These results suggest that it is possible to predict radiation-associated pathological fracture risk with high sensitivity and specificity. This would allow identification of high risk patients and treatment with prophylactic IM nail stabilization. Presentation of this model as a clinical nomogram will facilitate its clinical use.

Objectives: To investigate whether components of MSTS-87 (Pain, ROM, Strength, Stability, Deformity, Acceptance and Function) correlate with function as measured by TESS following endoprosthetic replacement (EPR) for patients with bone sarcoma.

Methods: 255 patients with extremity bone sarcoma treated by resection & EPR were identified from a prospective database. From this group we investigated 111 patients with primary bone sarcoma with > 2 years follow up, evaluated by both MSTS-87 & TESS, no local recurrence, metastasis or major complication for at least 2 years prior to the follow-up. Upper extremity patients were excluded due to small numbers. We examined the influence of patient demographics and tumour characteristics on functional outcome scores. Correlation between MSTS-87 & TESS was performed using linear regression analysis.

Results: Age, gender, tumour size, anatomical site, chemotherapy treatment and presence of pathological fracture did not significantly correlate with TESS. Linear regression analysis of MSTS-87 individual criteria and total score revealed that only pain, ROM and function helped explain the TESS score (p < 0.05) while strength, stability, deformity & acceptance had no significant effect on overall functional outcome.

Conclusions: Of the seven MSTS-87 variables, only pain, ROM and function significantly correlate with overall functional outcome as measured by TESS following EPR for bone sarcoma. This suggests that patients with decreased strength, stability, deformity and acceptance as defined by MSTS-87 scores, may still adapt well with good overall functional outcomes.

Purpose: To formulate a scoring system enabling decision making for prophylactic stabilization of the femur following surgical resection of a soft tissue sarcoma (STS) of the thigh.

Method: A logistic regression model was developed using patient variables collected from a prospective database. The test group included 22 patients with radiation-related pathological femur fracture following surgery and radiation for a thigh STS. The control group of 79 patients had similar treatment but without a fracture. No patients received chemotherapy. Mean follow-up was 8.6 years. Variables examined were: Age (70 years), gender, tumor size (0–7, 8–14, > 14 cm), radiation dose (low=5000 cGy, high> 6000 cGy), extent of periosteal stripping (20 cm) and thigh compartment (posterior, adductor, anterior). A score was assigned to each variable category based on the coefficients obtained in the logistic regression model.

Results: Based on the regression model and an optimal cut-point, the ability to predict radiation associated fracture risk was 91% sensitive and 86% specific. The area under the Receiver Operating Characteristic (ROC) curve was 0.9, which supports this model as a very accurate predictor.

Conclusion: Radiation-related femur fractures following combined surgery and radiation treatment for STS are uncommon, but are difficult to manage and their non-union rate is extremely high. These results suggest that it is possible to predict radiation-associated pathological fracture risk with high sensitivity and specificity. This would allow identification of high risk patients and treatment with prophylactic IM nail stabilization. Presentation of this model as a clinical nomogram will facilitate its clinical use.

Objectives: Well fixed, ingrown stems in patients with infected, uncemented knee tumor prostheses are difficult to remove. We have shown that it?s not necessary to remove them for infection control. We describe a technique for intraoperative fabrication of antibiotic-impregnated temporary cement prostheses using rush pin endoskeleton during first stage revision of infected, uncemented knee tumor prostheses.

Methods: We used this method in 7 patients with infected uncemented tumor prostheses around the knee. Two patients are awaiting second stage procedures. Surgery involved removing exchangeable components and retaining well-ingrown stemmed intramedullary components. Spacers were made of Rush pins that were bent and placed through hinge of retained component to allow knee movement. Antibiotic impregnated cement was placed around pins.

Results: This method allowed partial weight-bearing, knee movement, stability and pain control between first and second stages. In 4/5 patients infection was eradicated. Second-stage reimplantations were accomplished successfully in 3/5 patients with no obvious metal wear. Mean interval between the 2 stages was 12 weeks. One patient had residual infection requiring amputation and one patient did not agree to further surgery. Overall functional outcome following revision was TESS 82.3/100, MSTS93 73.3/100, MSTS87 23.3/35.

Conclusions: The technique allows maintenance of length, stability and knee joint movement, thus subsequent revision becomes technically simpler. Cement construct has large surface area to maximize antibiotic elution. This method has advantages of low cost, availability of numerous pin dimensions, which allows a custom component. Although there is no obvious wear, this remains a potential concern at articulation of rush rods and retained component.

Background: Displaced proximal humeral fractures (PHF) remain a challenge to the orthopedic surgeon. Conservative treatment yield poor results in the majority of these fractures. Surgical treatment, although preferable, lacks the proper exposure and fixation technique.

The locking compression plate (LCP), which is inserted in a minimal invasive technique, utilizing an anterolateral approach to the proximal humerus, allows adequate reduction and fixation, while minimizing the risk for complications derived from extensive exposure and poor fixation.

Methods: All patients admitted to our department with a complicated PHF between Jan 2004 and May 2005 were included. After obtaining informed consent, open reduction and internal fixation was performed through an anterolateral minimal invasive approach. After exposure and reduction with or without acromioplasty and rotator cuff repair, the fracture was fixated with a LCP 3.5mm. Patients were encouraged to perform pendular movements on the first post-operative day.

The patients were followed closely beginning 2 weeks post-operatively and afterwards on a bi-monthly basis. Immediate complications, radiographic and functional outcome were noted.

Results: 22 patients have been treated according to the treatment protocol during the study period. Minimal follow up of three months is available. A single complication was noted (deep wound infection which necessitated hardware removal). No nerve injury or hardware failures were noted.

Functional outcome was good, patients regained 120°±25 of flexion, 112°±27 of abduction and 17°±8 of external rotation.

Conclusions: The anterolateral approach to the shoulder and fixation with a LCP plate is a safe technique in our hospital. Rigid stabilization allows for early shoulder activation which results in a good range of motion and functional outcome on short-term follow up. Further study and long-term follow up are needed to validate this technique in treating complex proximal humerus fractures.

Introduction: MRI is considered to be highly effective in the diagnosis of internal derangement of the knee after acute trauma. 90–95% of meniscal and ligamentous injuries can be diagnosed by MRI and diagnostic arthroscopy can be effectively replaced with this modality. The drawbacks of MRI are its cost and availability. In recent years limited bone SPECT scan has been introduced as an alternative to MRI in the preoperative workup of patients with suspected meniscal and ligamentous injuries.

Purpose: To evaluate the diagnostic accuracy of bone SPECT in the pre-operative work up of patients with suspected meniscal tears.

Materials and Methods: 47 patients were included, average age was 41.9 years (range 18–78 years), 61.7% of the patients are male and 38.3% female. The results of limited bone SPECT scans of the knee were evaluated for accuracy as compared to the diagnosis established by knee arthroscopy, which is considered the gold standard for the diagnosis of meniscal tears.

Results: Bone SPECT scan of the knee was sensitive in 91.9% and specific in 20% of the cases compared to arthroscopy in the diagnosis of meniscal tears.

Positive predictive value calculated for SPECT is 81%, while the negative predictive value calculated is 40%. Separate calculations revealed a PPV of 90.5% in medial meniscal tears and a PPV of 86.7% in lateral meniscal tears respectively. In 13 cases additional inra-articular pathology was noted. In five cases the presumptive diagnosis of a meniscal tear on SPECT was rejected on arthroscopy, in three of these cases the anterior cruciate ligament was injured. One patient with a negative SPECT scan was operated and a meniscal tear found.

Discussion: The diagnostic accuracy of bone SPECT in suspected tears of the meniscus has not been fully validated. Our results correlate with results shown by other authors who reported a sensitivity of about 90 %. The value of the calculated specificity is difficult to interpretation, while patients with a negative SPECT scan are usually not operated. In these cases the SPECT scan should be compared to MRI results when available. In our setup bone SPECT should be included in the preoperative workup whenever the clinical diagnosis of a meniscal tear is doubtful until MRI becomes more readily available.

Introduction: Olecranon fractures comprise 4–7% of all fractures around the elbow in the pediatric age group. 80% of these fractures can be treated expectantly. Fractures with 2 mm of displacement or more require surgical intervention. The surgical procedure commonly used is ORIF with 2 Kirschner wires and tension band wire as advocated by the AO technique. All open interventions require removal of hardware under anesthesia. We present our experience of five cases treated with percutaneously placed K-wires and absorbable sutures.

Patients and Methods: Five patients, 4 boys and one girl, average age 6 8/12 years (range 4½-14¼ years) with displaced fractures of the olecranon were treated with ORIF during the years 2000–2004. In two cases additional injuries were noted [a displaced lateral condyle fracture in one and a dislocated radial head (Monteggia variant) in another patient].

Under general anesthesia, the olecranon is approached through a posterior incision. After reduction, fixation is achieved with two K-wires, which are inserted percutaneously. Additional fixation is obtained with a heavy absorbable suture (Dexon, PDS) which is fashioned in a figure of eight around the protruding pins and through a hole in the proximal ulna. Stability is checked under vision before wound closure. K-wires are trimmed and a plaster cast is fitted with the elbow in flexion. The plaster cast and K-wires are removed 4 weeks post surgery after X-rays confirm that the fracture is healed and range of motion is started.

Results: Five patients have been treated with our technique; all fractures were reduced and stable in flexion and extension under vision at the end of surgery.

K-wires were removed 4 weeks postoperatively and patients were allowed free range of motion. No immediate complications were noted, none became infected and no loss of fixation was observed.

Conclusions: Anatomic reduction and stable fixation can be achieved by the surgical technique presented. The usual complication of hardware irritation and the need for additional surgery to remove K-wires and the metal TBW are avoided by the use of absorbable sutures and protruding K-wires. Functional outcome is excellent on short term follow-up. Larger numbers and prospective follow-up will tell whether this technique can replace the commonly used methods of olecranon fracture fixation in the pediatric age group.

Background: Treatment of patients with partially or totally unstable pelvic ring disruptions includes primary anterior stabilization with an external fixator and additional posterior internal fixation. Iliosacral screws placed percutaneously under fluoroscopy or navigation guided techniques are widely accepted today to address the posterior lesions. Definite surgery is usually performed on a semi-emergent basis, whereas a delay of more than seven days in definite fixation is accompanied by a high rate of pulmonary complications, malreduction and infections.

Purpose: To compare the outcome of patients with type B and C pelvic ring disruptions treated with immediate definite posterior fixation (within 24 hours) as compared to those treated with early fixation (24–96 hours from arrival).

Patients and Methods: The medical records of 44 patients with type B and C pelvic ring disruptions were reviewed retrospectively. All posterior lesions were treated with closed reduction and internal fixation with percutaneously placed posterior iliosacral screws. Patients were divided into two groups, based on the time of definite fracture fixation from admittance to the ER. Immediate treatment included patients treated within 24 hrs of arrival (Group A), early intervention was defined as definite fracture fixation between 24–96 hrs from the patient’s arrival (Group B). Post operative radiographs (Pelvis AP, inlet and outlet) were used to assess the quality of final fracture reduction. Patient records were screened for demographic data, injury severity score and early morbidity and mortality.

Results: Forty-four patients were treated between the years 1999–2002 due to posterior pelvic ring fractures. 70.5% of the patients were male, the majority of patients (41/44) were injured during motor vehicle accidents, two patients sustained work-related crush injuries and one patient was injured during a suicide attempt. Fracture patterns were classified according to the Tile classification, there were 31 type B and 13 type C fractures. Thirty patients were treated within 24 hrs of admittance to the ER (group A), fourteen were treated between 24 and 96 hrs from arrival (Group B). ISS averaged 19.5 in group A as compared to 17.8 in group B (p=0.74). Overall complication rates were low. Malreduction was noted in one patient (group A), one patient in each group became infected, S1 foraminal penetration occurred in two patients (Group A). Two patients in group A died due to complications not related to the orthopedic intervention. No significant difference was found between the complication rates in both groups (p=0.34).

Conclusions: Immediate definite fixation of posterior pelvic lesions can be safely performed with posterior iliosacral screws. Comfortable nursing and early mobilization can be achieved without compromising the quality of fracture reduction and minimizes post-operative complications.