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Highly cross-linked polyethylene (HXLPE) has decreased wear and revision rates in total hip replacement (THR) at a long-term. However, the effect of HXLPE manufacturing characteristics on femoral head penetration has not been clearly defined yet. We report this single-institution study to investigate the clinical and radiological results of different HXLPE liners in THR.

In this retrospective cohort analysis of our prospective database, we identified 904 THRs performed between 2000 and 2013. Seven different HXLPE liner types were assessed: remelted (3), annealed (2), sequentially annealed (1) and vitamin E-infused (1). The linear femoral head penetration rate was measured at six weeks, one year, and annually thereafter, using the Roman Software v1.70 package.

Thirty hips were revised for the following reasons: aseptic loosening (11), dislocation (12), periprosthetic femoral fracture (6), and infection (1). No hip was revised for wear or osteolysis. 741 THRs were evaluated for a mean follow-up of 15 years (range, 10 to 20). The mean total penetration 15 years after THR was 0.17 mm in the sequentially annealed, and 0.16 mm in the vitamin E-infused groups, whereas it was 0.26 mm in the melted 95 kGy, 0.27 mm in the melted 5 Mrad and 0.25 mm in the melted 100 kGy groups (p=0.001). From one to 15 years after surgery, the mean wear was 0.206 mm in cups with an acetabular inclination greater than 50º and 0.105 mm in those placed between 35º and 50º (p<0.001).

Although HXLPE characteristics can result in a different wear performance in patients undergoing THR at a mean follow-up of 15 years, the clinical results are excellent. The position of the acetabular component can influence on the femoral head penetration of modern HXLPEs. Nevertheless, these patients should continue to be monitored to detect future problems.


The Bone & Joint Journal
Vol. 103-B, Issue 3 | Pages 492 - 499
1 Mar 2021
Garcia-Rey E Saldaña L Garcia-Cimbrelo E

Aims

Bone stock restoration of acetabular bone defects using impaction bone grafting (IBG) in total hip arthroplasty may facilitate future re-revision in the event of failure of the reconstruction. We hypothesized that the acetabular bone defect during re-revision surgery after IBG was smaller than during the previous revision surgery. The clinical and radiological results of re-revisions with repeated use of IBG were also analyzed.

Methods

In a series of 382 acetabular revisions using IBG and a cemented component, 45 hips (45 patients) that had failed due to aseptic loosening were re-revised between 1992 and 2016. Acetabular bone defects graded according to Paprosky during the first and the re-revision surgery were compared. Clinical and radiological findings were analyzed over time. Survival analysis was performed using a competing risk analysis.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 63 - 63
1 Feb 2020
Garcia-Rey E Cimbrelo EG
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Introduction

Total hip arthroplasty (THA) dislocation has been associated with different risk factors. The main difficulty in analysing dislocation is its low rate of incidence, necessitating large series for study.

We assessed factors related with patients, implant characteristics, and quality of the hip reconstruction to better identify their influence on the THA dislocation rate.

Material and Methods

Dislocations in 2,732 THAs performed between 2001 and 2016 were assessed with regard to factors related with the patient (gender, age, preoperative diagnosis, lumbar pathology); the implant (femoral head size, bearing surface, stem offset, femoral head/neck ratio); and the surgical technique (approach, cup and stem position, and abductor mechanism reconstruction). Regression analysis was used for different risk factors and Kaplan-Meier for survival analysis.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 65 - 65
1 Feb 2020
Garcia-Rey E Garcia-Cimbrelo E
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Introduction

Pelvic tilt can vary over time due to aging and the possible appearance of sagittal spine disorders. Cup position in total hip arthroplasty (THA) can be influenced due to these changes. We assessed the evolution of pelvic tilt and cup position after THA and the possible appearance of complications for a minimum follow-up of ten years.

Materials and methods

343 patients received a cementless THA between 2006 and 2009. All were diagnosed with primary osteoarthritis and their mean age was 63.3 years (range, 56 to 80). 168 were women and 175 men. 250 had no significant lumbar pathology, 76 had significant lumbar pathology and 16 had lumbar fusion. Radiological analysis included sacro-femoral-pubic (SFP), acetabular abduction (AA) and anteversion cup (AV) angles. Measurements were done pre-operatively and at 6 weeks, and at five and ten years post-operatively. Three measurements were recorded and the mean obtained at all intervals. All radiographs were evaluated by the same author, who was not involved in the surgery.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 58 - 58
1 Feb 2020
Garcia-Rey E Garcia-Cimbrelo E
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Introduction

Biological repair of acetabular bone defects after impaction bone grafting (IBG) in total hip arthroplasty could facilitate future re-revisions in case of failure of the reconstruction again using the same technique. Few studies have analysed the outcome of these acetabular re-revisions.

Patients and Methods

We analysed 34 consecutive acetabular re-revisions that repeated IBG and a cemented cup in a cohort of 330 acetabular IBG revisions. Fresh-frozen femoral head allografts were morselized manually. All data were prospectively collected. Kaplan-Meier survivorship analysis was performed. The mean follow-up after re-revision was 7.2 years (2–17). Intraoperative bone defect had lessened after the first failed revision. At the first revision there were 14 hips with Paprosky 3A and 20 with Paprosky type 3B. At the re-revision there were 5 hips with Paproky 2B, 21 with Paprosky type 3A and 8 with type 3B. Lateral mesh was used in 19 hips.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_4 | Pages 25 - 25
1 Apr 2019
Garcia-Rey E Garcia-Maya B Gomez-Luque J
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Introduction

Although pelvic tilt does not significantly change after primary total hip arthroplasty (THA) at a short term, can vary over time due to aging and the possible appearence of sagittal spine disorders. Cup positioning relative to the stem can be influenced due to these changes.

Purpose

We assessed the evolution of pelvic tilt and cup position after THA for a minimum follow-up of five years and the possible appearence of complications.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_4 | Pages 23 - 23
1 Apr 2019
Garcia-Rey E Garcia-Cimbrelo E Carbonell R
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Background

Aseptic loosening is rare with most cementless tapered stems in primary total hip arthroplasty (THA), however different factors can modify results. We ask if the shape and technique of three current different femoral components affects the clinical and radiological outcome after a minimum follow-up of ten years.

Methods

889 cementless tapered stems implanted from 1999 to 2007 were prospectively followed. Group 1 (273 hips) shared a conical shape and a porous-coated surface, group 2 (286 hips) a conical splined shape and group 3 (330 hips) a rectangular stem. Clinical outcome and anteroposterior and sagittal radiographic analysis were compared. Femoral type, stem position, femoral canal filling at three levels and the possible appearance of loosening and bone remodelling changes were assessed.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_4 | Pages 24 - 24
1 Apr 2019
Garcia-Rey E Garcia-Cimbrelo E
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Introduction

Impaction bone grafting (IBG) is a reliable technique for acetabular revision surgery with large segmental defects. However, bone graft resorption and cup migration are some of the limitations of this tecnique. We assess frequency and outcome of these complications in a large acetabular IBG series.

Patients and Methods

We analysed 330 consecutive hips that received acetabular IBG and a cemented cup in revision surgery with large bone defects (Paprosky types 3A and 3B). Fresh-frozen femoral head allograft was morselized manually. The mean follow-up was 17 years (3–26). All data were prospectively collected. Kaplan-Meier survivorship analysis was performed. Changes in different paremeters regarding cup position were assessed pre- and postoperatively and at the follow- up controls. Only variations greater than 5º and 3 mm were considered.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_5 | Pages 60 - 60
1 Apr 2018
Garcia-Rey E Cimbrelo EG
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Introduction

Durable bone fixation of uncemented porous-coated acetabular cups can be observed at a long-term, however, polyethylene (PE) wear and osteolysis may affect survivorship. Accurate wear measurements correlated with clinical data may offer unique research information of clinical interest about this highly debated issue.

Objetive

We assessed the clinical and radiological outcome of a single uncemented total hip replacement (THR) after twenty years analysing polyethylene wear and the appearance of osteolysis.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_3 | Pages 9 - 9
1 Apr 2018
Garcia-Rey E Carbonell R Cordero J Gomez-Barrena E
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Introduction

Durable bone fixation of uncemented porous-coated acetabular cups can be observed at a long-term, however, polyethylene (PE) wear and osteolysis may affect survivorship. Accurate wear measurements correlated with clinical data may offer unique research information of clinical interest about this highly debated issue.

Objetive

We assessed the clinical and radiological outcome of a single uncemented total hip replacement (THR) system after twenty years analysing polyethylene wear and the appearance of osteolysis.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_5 | Pages 58 - 58
1 Apr 2018
Garcia-Rey E Garcia-Cimbrelo E Sedel L
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Introduction

Acetabular fractures management is controversial since, despite a good anatomical reduction, clinical outcome is not satisfactory very often and the probability of a total hip arthroplasty (THA) is high. Surgical treatment include long operating times, large approach, blood loss, neural and muscle damage, and a high risk of failure and secondary osteoarthritis related to bone necrosis, cartilage damage, and bone loss.

We hypothesized that the acetabular fracture management affected the clinical and radiological outcome of THA after posttraumatic arthritis.

Materials and Methods

We compared 49 patients (49 hips) initially treated conservatively followed some months later by THA in conjunction with acetabular reconstruction (group 1); and 29 patients (29 hips) who had undergone THA after a failed osteosynthesis (group 2). There were more associated fractures according to Letournel in group 2. The mean age was 59.3±15.8 years for group 1 and 52.9±15.2 years for group 2. The mean delay between fracture and THA was 75.4±5 months for group 1 and 59.4±5 for group 2. The mean follow-up was 11.7 in group 1 and 10.2 in group 2. Preoperative bone defect was similar. We used bone autograft in 13 hips (26.5%) in group 1 and four (13.6%) in group 2. We used acetabular reconstruction plates in 2 hips with a pelvic discontinuity in group 1. Complications, clinical outcome according to Harris Hip Score, and radiological reconstruction were compared. Two-way ANOVA with repeated measures were used for comparison.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_5 | Pages 59 - 59
1 Apr 2018
Garcia-Rey E Cimbrelo EG
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Introduction

Implantation of total hip replacement (THR) remains a concern in patients with developmental dysplasia of the hip (DDH) because of bone deformities and previous surgeries. In this frequently young population, anatomical reconstruction of the hip rotation centre is particularly challenging in severe, low and high dislocation, DDH. The basic principles of the technique and the implant selection may affect the long-term results.

The aim of the study was to compare surgical difficulties and outcome in patients who underwent THR due to arthritis secondary to moderate or severe DDH.

Material and Methods

We assessed 131 hips in patients with moderate DDH (group 1) and 56 with severe DDH (Group 2) who underwent an alumina-on-alumina THR between 1999 and 2012. The mean follow-up was 11.3 years (range, 5 to 18). Mean age was 51.4 years in group 1 and 42.2 in group 2. There were previous surgery in 5 hips in group 1 and in 20 in group 2 (p<0.001). A dysplastic acetabular shape type C according to Dorr and a radiological cylindrical femur were both more frequent in group 2 (in both cases p<0.001). We always tried to place the acetabular component in the true acetabulum. Smaller cups (p<0.001), screw use for primary fixation (p<0.001) and bone autograft used as segmental reinforcement in cases of roof deficiency (p<0.001) were more frequent in group 2. Radiological analysis of the cup included acetabular abduction, version and Wiberg angles, horizontal, vertical, and hip rotation centre distances, and acetabular head index. Abductor mechanism reconstruction according to the lever arm distance and height of the greater trochanter was also evaluated. Cup placement within or outside Lewinnek´s safe zone was recorded. Two-way ANOVA with repeated measures were used to analyse clinical and radiological changes.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 49 - 49
1 Jan 2018
Garcia-Cimbrelo E Garcia-Rey E Sedel L
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Different pathologies, deformities, bone defects, previous surgeries and polyethylene wear limit the survival of total hip arthroplasty (THA) in young patients. We compare preoperative status and outcome in 171 young and very young patients (207 hips) who underwent a ceramic-on-ceramic THA. Sixty-three (77 hips) were less than 30 years old (group 1) and 108 (130) were between 30 and 40 years old. Mean follow-up was 11.3 years. Two-way ANOVA with repeated measures were used to analyse clinical and radiological changes.

Juvenile rheumatoid arthritis (JRA) was the most frequent diagnosis in group 1 and avascular necrosis in group 2. Charnley class type C, low activivity, previous surgery and osteoporotic bone were more frequent in group 1 patients. There were 2 cup revisions for aseptic loosening in group 1 and 4 in group 2. Survivorship analysis at 15 years was 96.7% (95% IC 92.2 a 100) for group 1 and 96.1% (95% IC 92.2 to 100) for group 2 (p=0.749). Despite the worse preoperative status in group 1 patients, clinical outcome was similar in both groups. Severe dysplasia had the worst clinical result and avascular necrosis the best. Patients with Charnley class C and JRA showed the most improvement. Radiographic reconstruction of the abduction angle was worse in group 1 (p=0.02). No osteolysis or complications derived from ceramic use were found.

We conclude that despite the worse preoperative status in group 1 patients, clinical and radiographic results were good in both groups of patients who received a ceramic-on-ceramic THA.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_3 | Pages 130 - 130
1 Feb 2017
Garcia-Rey E Cimbrelo EG Gomez-Barrena E
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Background and aim

Despite good survivorship analysis for most uncemented tapered straight stems, new proposals modifying stem design in total hip replacement (THR) are being introduced in order to facilitate femoral revision surgery.

We have evaluated the clinical and radiological results of four different designs of uncemented tapered straight stems implanted in our institution in order to assess: operative complications, clinical results, survivorship analysis for aseptic loosening and radiographic findings

Methods

1008 hips implanted from 1998 to 2006 were prospectively followed for a mean of 12 years (range, 10 to 17). Four uncemented femoral designs employing a tapered straight stem were included: 209 Alloclassic stems, 420 Cerafit, 220 SL-Plus and 159 Summit. All hips had a 28 or 32 mm femoral head, and polyethylene (PE)-on metal or ceramic-on-ceramic bearing surface. Radiological femoral type, stem position, femoral canal filling at three levels and the possible appearance of loosening and other bone remodelling changes were recorded in all hips.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_3 | Pages 131 - 131
1 Feb 2017
Garcia-Rey E Cimbrelo EG Cruz-Pardos A
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Background and aim

A significant reduction in wear using Durasul highly cross-linked polyethylene (PE) versus Sulene polyethylene (sterilized with nitrogen) at 5 and 10 years have been reported previously. We ask if the improvement observed at the earlier follow-up continues at 15 years.

Methods

Between 1999 and 2001, 90 hips underwent surgery using the same cementless cup and stem: 45 received Allofit cups with a Sulene-PE liner and 45 Allofit cups with a Durasul-PE liner, both associated with an Alloclassic stem (28 mm metallic femoral head). 66 hips of this prospective comparative study were available over a minimum follow-up of 15 years. Linear femoral head penetration was estimated digitally at 6 weeks, at 6 and 12 months and annually thereafter, using the Dorr method, given the nonspherical cup shape. All radiographs were evaluated by the same author, who was not involved in surgery.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_3 | Pages 129 - 129
1 Feb 2017
Garcia-Rey E Cimbrelo EG
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Background and aim

Total hip replacement (THR) in young patients has been associated to higher revision rates than in older population. Different conditions may lead to end-stage arthritis of the hip in these patients.

We compared the clinical and radiological outcome of two different groups of young and very young patients who underwent a ceramic-on-ceramic THR.

Patients and Methods

120 hips were prospectively followed for a mean of 10.4 years (range, 5 to 17). 38 patients (46 hips) were less than 30 years old (group 1), and, 68 (74 hips) were between 31 and 40 years old (group 2). Weight (p<0.001) and physical activity level were greater in group 2 (p<0.001). Preoperative function (p=0.03) and range of mobility (p=0.03) were worse in group 1. Primary osteoarthritis was not found in any case. Rheumatoid juvenile arthritis was the most frequent diagnosis in group 1 and avascular necrosis of the femoral head in group 2. A femoral funnel-shaped type 1 according to Dorr was more frequent in group 2 (p=0.04). The same ceramic-on-ceramic uncemented THR was used in all cases. Screws for cup fixation were only used when strictly needed. We analysed the clinical results according to the Merle-D´Aubignè and Postel scale, the postoperative radiological reconstruction of the hip and the radiological appearance of cup loosening. Kaplan-Meier survivorship analysis was used to estimate the cumulative probability of not having a revision surgery.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 146 - 146
1 May 2016
Garcia-Cimbrelo E Garcia-Rey E
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Introduction

Alumina-on-alumina in total hip replacement has been used for avoiding osteolysis and loosening. Published series report no ceramic wear and low rates for fractures and noises, but report poor results because of acetabular fixation failure. From 1999 to 2005, we used the “first generation” of a cementless cup, tri-radius relatively-smoothed HA coated (group 1), and from 2006 we have used a “second-generation” of this same cementless cup design with a macrotextured surface (group 2). We compare the perioperative conditions of two groups of patients using these two different cups and the clinical and radiological results.

Material and Methods

We analysed 679 (612 patients) consecutive and non-selected primary cementless alumina-on-alumina prostheses. There were 342 hips in group 1 and 337 in group 2. The stem used for all patients in this series was the same and fitted with an Al2O3 liner and femoral head. The use of screws were according to the intraoperative stability of the cup (pull-out test). Patients’ mean age was 48.7+13.6 years and the average follow-up until revision or the last evaluation was 11.7 years for group 1 and 5.4 years for group 2.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 147 - 147
1 May 2016
Garcia-Rey E Garcia-Cimbrelo E
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Background and aim

Recent proposals have been introduced to modify stem design and/or femoral fixation in total hip replacement (THR). New designs need to consider previous design features and their results. The aim of this study has been to evaluate the clinical and radiological results of six different designs of tapered uncemented stems implanted in our Institution.

Methods

1918 uncemented hips were prospectively assessed from 1999 to 2011 (minimum follow-up of five years for the unrevised hips). All hips had a 28 or 32 mm femoral head and metal-on-polyethylene or alumina-on-alumina bearing surface. Six uncemented femoral designs that shared a femoral tapered stem incorporating a coating surface were included in the study. The different design features included the type of coating, metaphyseal filling, and sectional shape.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 148 - 148
1 May 2016
Garcia-Rey E Garcia-Cimbrelo E
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Introduction

The use of screws is frequent for additional fixation, however, since some disadvantages have been reported a cup press-fit is desirable, although this can not always be obtained. Cup primary intraoperative fixation in uncemented total hip replacement (THR) depends on sex, acetabular shape, and surgical technique. We analyzed different factors related to primary bone fixation of five different designs in patients only diagnosed with osteoarthritis, excluding severe congenital hip disease and inflammatory arthritis, and their clinical and radiological outcome.

Materials y Methods

791 hips operated in our Institution between 2002 and 2012 were included for the analysis. All cases were operated with the same press-fit technique, and screws were used according to the pull-out test. Two screws were used if there was any movement after the mentioned manoeuvres. Acetabular and femoral radiological shapes were classified according to Dorr et al. We analyzed radiological postoperative cup position for acetabular abduction angle, the horizontal distance and the vertical distance. Cup anteversion was evaluated according to Widmer and the hip rotation centre according to Ranawat.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 145 - 145
1 May 2016
Garcia-Cimbrelo E Garcia-Rey E
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Although cemented fixation provides excellent results in primary total hip replacement (THR), particularly in patients older than 75 years, uncemented implants are most commonly used nowadays. We compare the rate of complications, clinical and radiological results of three different designs over 75-years-old patients.

Materials and Methods

433 hips implanted in patients over 75 years old were identified from our Local Joint Registry. Group A consisted of 139 tapered cemented hips, group B of 140 tapered grit-blasted uncemented hips and group C of 154 tapered porous-coated uncemented hips. A 28 mm femoral head size on polyethylene was used in all cases. The mean age was greater in group A and the physical activity level according to Devane was lower in this group (p<0.001 for both variables). Primary osteoarthritis was the most frequent diagnoses in all groups. The radiological acetabular shape was similar according to Dorr, however, an osteopenic-cylindrical femur was most frequently observed in group A (p<0.001). The pre- and post-operative clinical results were evaluated according to the Merle-D'Aubigne and Postel scale. Radiological cup position was assessed, including hip rotation centre distance according to Ranawat and cup anteversion according to Widmer. We also evaluated the lever arm and height of the greater trochanter distances and the stem position. Kaplan-Meier analysis was done for revision for any cause and loosening.

Results

The hip rotation centre distance was greater and the height of the greater trochanter was lower in group B (p=0.003, p<0.001, respectively). The lever arm distance was lower in group C (p<0.001). A varus stem position was more frequently observed in group B (p<0.001). There were no intra- or post-operative fractures in group A, although there were five intra-operative fractures in the other groups plus two post-operative fractures in group B and four in group C. The rate of dislocation was similar among groups and was the most frequent cause for revision surgery (8 hips for the whole series). The mean post-operative clinical score improved in all groups. The overall survival rate for revision for any cause at 120 months was 88.4% (95% CI 78.8–98), being 97.8% (95% CI 95.2–100) for group A, 81.8% (95% CI 64.8–98.8) for group B and 95.3% (95% CI 91.1–99.6) for group C (log Rank: 0.416). Five hips were revised for loosening. The overall survival rate for loosening at 120 months was 91.9% (95% CI 81.7–100), being 99.2%(95% CI 97.6–100) for group A, 85.5 (95% CI 69.9 −100) for group B and 100% for group C (Log Rank 0.093).