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Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_12 | Pages 27 - 27
1 Mar 2013
D. Harrison W Johnson-Lynn S Cloke D Candal-Couto J
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Subacromial corticosteroid injections are a well-recognised management for chronic shoulder pain and are routinely used in general practice and musculoskeletal clinics. Mycobacterium tuberculosis (TB) of a joint is a rare presentation in the United Kingdom. International literature exists for cases of reactivated latent tuberculosis following intra-articular corticosteroid injections in a knee; however there are no reports of a primary presentation of undiagnosed TB in a joint following therapeutic corticosteroid injections.

A seventy-four year old lady presented with a one-year history of a painful shoulder, which clinically manifested as a rotator cuff tear with impingement syndrome. Following three subacromial depo-medrone injections, the patient developed a painless “cold” lump which was investigated as a suspicious, possibly metastatic lesion. This lump slowly developed a sinus and a subsequent MRI scan identified a large intra-articular abscess formation. The sinus then progressed to a large intra-articular 5×8 cm cavity with exposed bone (picture available). The patient had no diagnosis of TB but had pathogen exposure as a child via her parents.

The patient underwent three weeks of multiple débridement and intravenous amoxicillin/flucloxacillin to treat Staphylococcus aureus grown on an initial culture. Despite best efforts the wound further dehisced with a very painful and immobile shoulder. Given the poor response to penicillin and ongoing wound breakdown there was a suspicion of TB. After a further fortnight, Mycobacterium tuberculosis was eventually cultured and quadruple antimicrobial therapy commenced. Ongoing débridement of the rotator cuff and bone was required alongside two months of unremitting closed vacuum dressing. The wound remained persistently open and excision of the humeral head was necessary, followed by secondary wound closure. There were no extra-articular manifestations of TB in this patient. At present the shoulder is de-functioned, the wound healed and shoulder pain free.

This unique case study highlights that intra-articular corticosteroid can precipitate the first presentation of Mycobacterium tuberculosis septic arthritis. The evolution of symptoms mimic many other shoulder complaints making confident diagnosis a challenge. The infective bone and joint destruction did not respond to the management described in the current literature. There remains a further management issues as to whether arthroplasty surgery can be offered to post-TB infected shoulder joints.

Taking a TB exposure history is indicated prior to local immunosuppressant injection, particularly in the older age group of western populations and ethnicities with known risk factors.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_II | Pages 99 - 99
1 Feb 2012
Candal-Couto J Gamble G Astley T Rothwell A Ball C
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The aim of the New Zealand National Shoulder Arthroplasty Register is to evaluate the provision of shoulder arthroplasty across the entire country by both recording accurate technical information and measuring the clinical outcomes of all shoulder replacements performed in New Zealand.

An initial form is completed at the time of surgery which includes details of the patient, surgical indications, the surgical procedure, the implant and the operating surgeon. Six months following surgery, all registered patients are asked to complete the Oxford Shoulder Score and comment on post-operative complications.

Data from 686 consecutive primary and 44 revision shoulder arthroplasties were prospectively collected from January 2000 until December 2003. 82 surgeons performed shoulder arthroplasty during the study period but only 9 performed on average more than 5 per year. Their results at 6 months were statistically superior to those provided by other surgeons. Amongst all diagnoses, osteoarthritis scored significantly better than the rest and for this condition total shoulder replacement scored higher than hemiarthroplasty. 15 different prostheses were used, many of them too infrequently. There was no difference in outcome amongst the 5 most commonly used prostheses. The number of complications reported by patients and the revision rate within the study period was low. No benefit was observed in the use of laminar flow theatre to prevent infection.

The combination of technical data about the joint implanted and the individual patient assessment has made the New Zealand Shoulder Arthroplasty Register unique in its own kind. Our findings are in general agreement with the current literature and supports the idea that shoulder arthroplasty is better provided by surgeons with a higher yearly case-load.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 292 - 293
1 Jul 2011
Jameson S James P Reed M Candal-Couto J
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Background: Diagnostic and operative codes are routinely collected on every patient admitted to hospital in England and Wales (hospital episode statistics, HES). Linked data allows post-operative complications to be associated with the primary operative procedure, even if patients are re-admitted following a successful discharge. Morbidity and mortality data on shoulder surgery have not previously been available in large numbers.

Methods: All HES data for a 42-month was analysed and divided into three groups – elective shoulder replacement (total or hemiarthroplasty), shoulder arthroscopy (all procedures), and proximal humerus fracture surgery (internal fixation or replacement). Incidence of pulmonary embolism (PE), deep venous thrombosis (DVT) and mortality within 90 days was established.

Results: For elective shoulder replacement (10735 patients), 90-day DVT, PE and mortality rates were 0.07%, 0.11% and 0.36% respectively. Mortality in patients over 75 years was 0.9%. For arthroscopic procedures (66344 patients), 90-day DVT, PE and mortality rates were 0.01%, 0.01% and 0.03%. For proximal humerus fracture surgery (internal fixation or replacement, 4968 patients) 90-day DVT, PE and mortality rates were 0.20%, 0.38% and 2.98%. Mortality in patients over 75 years old was 6.6%.

Discussion: Venous thromboembolic (VTE) prophylaxis is rarely used for upper limb surgery. PE and mortality rates for shoulder replacement and proximal humerus fracture surgery are lower those for patients receiving chemical prophylaxis after hip replacement. Further investigation into the cause of high mortality rates following fracture surgery in patients over 75 years old is required. VTE prophylaxis may be required in this age group.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 40 - 40
1 Mar 2009
Baker P Akra G Eardley W Candal-Couto J Liow R Rangan A
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Introduction: The surgical management of proximal humeral fractures continues to be an unsolved problem for the orthopaedic surgeon. Disagreement remains over how best to fix the more challenging complex fractures in younger patients where the ultimate goals of treatment are restoration of a painless shoulder, adequate function, and preservation of humeral head viability.

The PHILOS plate attempts to improve on previously designed implants by preserving the biological integrity of the humeral head articular fragment. The minimally invasive technique minimises soft tissue damage whilst at the same time securing the reduction using multiple locking screws with angular stability, thus allowing early mobilisation.

Methods: Retrospective review of the notes and x-ray images of 54 fractures treated with the PHILOS plate between Jan 2000 and Aug 2005. Data including baseline demographics, the presence of any complications and the need for reoperation were collected. In addition 43 (81%) patients were contacted and Oxford (OSS) and Disabilities of the Arm, Shoulder and Hand (DASH) scores were calculated to assess functional recovery. All patients were contacted at a minimum of 6 months following fixation with an average follow up of 18 months (Range 6–41 months)

We also present a cost analysis relating to the use of the PHILOS plate in practice.

Results: 54 fractures in 53 patients (25F:28M). Average age 54.4. There were 26 2-part, 15 3-part and 13 4-part fractures. A total of 11 (20%) patients had complications of which 7 (13%) required reoperation. These complications included deep infection (3 cases), AVN (4), Non Union (3) and plate impingement (1).

Mean OSS and DASH at follow up were 24.8 (S.D 11.6) and 28.0 (S.D 26.9) respectively. Worse scores were seen in those patients who had complications (OSS 39.4 Vs 22.6, DASH 58.2 Vs 23.4) although this difference was not statistically significant. There was also a trend for poorer scores with increasing fracture complexity and better scores in those patients operated upon by surgeons with a specific interest in the upper limb and in patients whose surgeon had performed more than 5 fixations.

Conclusion: Our series reports a much higher complication rate (20%) than that previously published. Whilst those patients who do not suffer complications reported good functional outcomes the presence of postoperative complications was associated with poorer results. Outcomes following surgery were affected by patient, implant and surgeon related factors. Given the high rate of serious complications and their detrimental affect on outcome surgeons should give serious consideration to the appropriateness of using such implants. To clarify these issues, further prospective randomised trials are needed.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 211 - 211
1 Jul 2008
Candal-Couto J Gamble G Astley T Rothwell A Ball C
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The aim of the New Zealand Elbow Arthroplasty Register is to evaluate the provision of elbow arthroplasty across the entire country by both recording accurate technical information and measuring the clinical outcomes of all elbow replacements performed in New Zealand. An initial form is completed at the time of surgery which includes details of the patient, surgical indications, the surgical procedure, the implant and the operating surgeon. Six months following surgery, all registered patients are asked to complete a questionnaire to measure the pain and function of the replaced elbow and to comment on any post operative complications. Data from 99 consecutive primary and 16 revision elbow arthroplasties was prospectively collected from January 2000 till December 2003. Rheumatoid arthritis was the commonest indication (63 cases) and the outcome was significantly better than for trauma and osteoarthritis. The Coonrad-Morrey was the most commonly used prosthesis (86 cases) followed by the Kudo (eight cases) and the Acclaim (five cases). 21 surgeons performed elbow arthroplasty during the study period but only five performed on average more than one case per year. Their results at six months were statistically superior to those provided by other surgeons. The number of complications reported by patients and the revision rate within the study period was low. An infection was seen in only two patients. The New Zealand Elbow Arthroplasty Register has become a robust method of assessment of the provision of elbow arthroplasty within the country. Our findings support the idea that elbow arthroplasty should not be performed by general orthopaedic surgeons on an occasional basis.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_III | Pages 401 - 401
1 Oct 2006
Ahmad M Nanda R Bajwa A Candal-Couto J Green S Hui A
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Aim: To investigate in vitro the mechanical stability of a locking compression plate (LCP) construct in a simulated diaphyseal fracture of the humerus at increasing distances between the plate and bone.

Materials & Method: A series of biomechanical in vitro experiments were performed using Composite Humerus Sawbone as the bone model. Osteotomy created in the mid-diaphyseal region. A 10mm osteotomy gap was bridged with a 7-hole 4.5 stainless steel plate with one of four methods: a control group consisted of a Dynamic Compression Plate applied flush to the bone and three study groups which comprised of a LCP applied flush to the bone, at 2mm and at 5mm from the bone. Standard AO technique used with locking head screws used for LCP fixation. Static and dynamic loading tests performed in a jig with the bone model fixed both proximally and distally. Samples were subjected to cyclical compression, compression load to failure, cyclical torque and torque to failure. Plastic deformation and failure was assessed. Scanning electron microscopy of the plate and screw surface allowed detailed inspection of micro-fracture in areas of fatigue.

Results: Consistent results were achieved in LCP constructs in which the plate was applied at or less than 2mm from the bone. When applied 5mm from the bone the LCP demonstrated significantly increased plastic deformation during cyclical compression and required lower loads to induce construct failure.

Conclusion: In our laboratory model a significant decrease in axial stiffness and torsional rigidity becomes evident at a distance of 5mm between plate and bone.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 244 - 244
1 Mar 2003
Candal-Couto J Burrow D Bromage S Briggs P
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Syndesmotic stability in ankle fractures is usually assessed by pulling on the fibula with a bone hook in the coronal plane (“hook test”). Our clinical observations have suggested that instability may be more marked in the sagittal plane.

Our aim was to compare movement at the tibio-fibular syndesmosis in the sagittal and coronal planes after sequential ligament division in a cadaver model.

Seven specimens were used. A blinded subject was asked to perform the hook test both in the sagittal and coronal planes. Movement was assessed by measuring the displacement of parallel k-wires three consecutive times. In all specimens, the anterior tibio-fibular, interosseous and posterior tibio-fibular ligaments were sequentially divided and movement tested. In three specimens the deltoid ligament was then divided and the interosseous membrane in another three.

After division of all three syndesmosis ligaments the mean displacement was 8.8mm (±3.9) in the sagittal plane and 1.5mm (±0.4) in the coronal plane. When the deltoid ligament was then divided, the displacement increased to 11.7mm (±2.4) and 3.2mm (±0.5) respectively. When the interosseous membrane was divided the measurements were 12.7mm (±4) and 3.1mm (±1.5).

We conclude that distal tibio-fibular instability should be assessed in the sagittal plane.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 179 - 179
1 Feb 2003
Candal-Couto J Reed M McCaskie A
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Research is regarded as an important part of higher surgical training, and forms an important component of in training assessment. Currently, there is little planning of research at a regional level. The aim of this study was, first, to evaluate the attitude of trainees towards research in order to highlight and understand difficulties. The second aim was to determine the level of support for a proposed research database to help organise regional research activity.

All trainees in a single region (39) were asked to complete a questionnaire handed out during two regional teaching days.

28 Questionnaires were returned. Nine percent of trainees have a higher degree with a further 35% on progress. Each trainee had an average of three (range 0–6) ongoing research projects. Over half the trainees had abandoned research projects. Most trainees stated an interest in research and felt that research was an important part of training and should be assessed in the RITA. Most trainees felt that research would dictate the quality of their consultant jobs. Almost every trainee stated that changing posts every eight months, as well as distance between hospital sites, made it difficult to complete projects. Every trainee felt that the ethical committee process causes significant delays in progress. Most felt that access to statistical advice was poor. Almost all trainees would welcome a regionally co-ordinated research database.

Trainees abandon research for various reasons. We propose that a research database would serve the primary function of linking trainees with consultants with quality research projects. Junior trainees would be encouraged to join the system and choose a project. The research section of the RITA could then focus on the progress of that project(s). Secondary aims would be coordinating access to advice on funding, statistics and ethics committee applications.